Pathogenicity Island: SPI-2


• General information

Name : SPI-2
Host strain : Salmonella enterica LT2
Function : Type III secretion system, required for systemic infection and intracellular pathogenesis by facilitating replication of intracellular bacteria within membrane-bound Salmonella-containing vacuoles (SsaJ, SseABC, SpiC)
Insertion site : tRNA-valV


• GenBank accessions: 7 records

1) AJ224892 (8457 bp)

    Definition : Salmonella typhimurium ssaE, sseA, sseB, sscA, sseC, sseD, sseE, sscB, sseF, sseG, ssaG, ssaH, ssaI genes and partial ssaD, ssaJ genes.

    Publication :
    - Hensel,M., Shea,J.E., Waterman,S.R., Mundy,R., Nikolaus,T., Banks,G., Vazquez-Torres,A., Gleeson,C., Fang,F.C. and Holden,D.W., "Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages", Mol. Microbiol. 30 (1), 163-174 (1998) PUBMED 9786193.

    - Hensel,M., "Direct Submission", Submitted (09-MAR-1998) Hensel M., Max von Pettenkofer-Insitut, Lehrstuhl Bakteriologie, Pettenkoferstr. 9a, D-80336 Munich, GERMANY REMARK Revised by author 10-JUL-98.


      





2) AJ224978 (12121 bp)

    Definition : Salmonella typhimurium, Salmonella Pathogenicity Island 2 (SPI2) genes, ttr gene cluster.

    Publication :
    - Hensel,M., Nikolaus,T. and Egelseer,C., "Molecular and functional analysis indicates a mosaic structure of Salmonella pathogenicity island 2", Mol. Microbiol. 31 (2), 489-498 (1999) PUBMED 10027966.

    - Hensel,M., Hinsley,A.P., Nikolaus,T., Sawers,G. and Berks,B.C., "he genetic basis of tetrathionate respiration in Salmonella typhimurium", Mol. Microbiol. In press.

    - Hensel,M., "Direct Submission", Submitted (10-MAR-1998) Hensel M., Lehrstuhl Bakteriologie, Max von Pettenkofer-Insitut, Munich, D-80336, GERMANY.


      





3) U51927 (5715 bp)

    Definition : Salmonella typhimurium SpiR and SpiB genes, partial cds, and SpiC and SpiA genes, complete cds.

    Publication :
    - Ochman,H., Soncini,F.C., Solomon,F. and Groisman,E.A., "Identification of a pathogenicity island required for Salmonella survival in host cells", Proc. Natl. Acad. Sci. U.S.A. 93 (15), 7800-7804 (1996) PUBMED 8755556.

    - Groisman,E.A., "Direct Submission", Submitted (20-MAR-1996) Eduardo A. Groisman, Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave. (Campus box 8230), St. Louis, MO 63110, USA.


      





4) X99944 (5484 bp)

    Definition : S.typhimurium ssaQ, ssaR, ssaS, ssaT and ssaU genes.

    Publication :
    - Hensel,M., Shea,J.E., Baumler,A.J., Gleeson,C., Blattner,F. and Holden,D.W., "Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12", J. Bacteriol. 179 (4), 1105-1111 (1997) PUBMED 9023191.

    - Hensel,M., "Direct Submission", Submitted (09-AUG-1996) M. Hensel, Max von Pettenkofer-Institut, Lehrstuhl fuer Bakteriologie, Pettenkofer Strasse 9a, 80336 Munich, FRG.


      





5) X99945 (4631 bp)

    Definition : S.typhimurium ORF's 32 & 48 & gene pykF.

    Publication :
    - Hensel,M., Shea,J.E., Baumler,A.J., Gleeson,C., Blattner,F. and Holden,D.W., "Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12", J. Bacteriol. 179 (4), 1105-1111 (1997) PUBMED 9023191.

    - Hensel,M., "Direct Submission", Submitted (09-AUG-1996) M. Hensel, Max von Pettenkofer-Institut, Lehrstuhl fuer Bakteriologie, Pettenkofer Strasse 9a, 80336 Munich, FRG.


      





6) Y09357 (8302 bp)

    Definition : S.typhimurium ssaJ, ssaK, ssaL, ssaM, ssaV, ssaN, ssaO, ssaP, ssaQ genes.

    Publication :
    - Hensel,M., Shea,J.E., Raupach,B., Monack,D., Falkow,S., Gleeson,C., Kubo,T. and Holden,D.W., "Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2", Mol. Microbiol. 24 (1), 155-167 (1997) PUBMED 9140973.

    - Hensel,M., "Direct Submission", Submitted (11-NOV-1996) M. Hensel, Max Von Pettenkofer-Insitut, Lehrstuhl fuer Bakteriologie, Pettenkofer Str. 9a, 80336 Munchen, FRG.


      





7) Z95891 (1252 bp)

    Definition : S.typhimurium ssrA and ssrB genes.

    Publication :
    - Hensel,M., Shea,J.E. and Holden,D.W., "Identification of the transcriptional activator of Salmonella Pathogenicity Island 2", Unpublished.

    - Hensel,M., "Direct Submission", Submitted (28-MAY-1997) Hensel M., Lehrstuhl fur Bakteriologie, Max von Pettenkofer-Institut, Pettenkofer Str. 9a, 80336 Munich, Germany REMARK Revised by [3].

    - Hensel,M., "Direct Submission", Submitted (10-JUL-1998) Hensel M., Lehrstuhl fur Bakteriologie, Max von Pettenkofer-Institut, Pettenkofer Str. 9a, 80336 Munich, Germany.


      





• PAI-like regions homologous to this PAI (genomes and locations)

NC_005085 (Chromobacterium violaceum ATCC 12472): 2.8 Mb
NC_012779 (Edwardsiella ictaluri 93-146): 0.9 Mb
NC_020796 (Edwardsiella tarda C07-087): 1.0 Mb
NC_013508 (Edwardsiella tarda EIB202): 1.0 Mb
NC_017309 (Edwardsiella tarda FL6-60): 0.9 Mb
NC_007645 (Hahella chejuensis KCTC 2396): 3.4 Mb
NC_018106 (Klebsiella oxytoca E718): 3.2 Mb
NC_016612 (Klebsiella oxytoca KCTC 1686): 4.5 Mb
NC_021870 (Salmonella bongori N268-08): 1.4 Mb
NC_015761 (Salmonella bongori NCTC 12419): 1.3 Mb
NC_021820 (Salmonella enterica 08-1736): 2.7 Mb
NC_016856 (Salmonella enterica 14028S): 1.5 Mb
NC_011274 (Salmonella enterica 287/91): 1.8 Mb
NC_022241 (Salmonella enterica 3114): 1.4 Mb
NC_021810 (Salmonella enterica 41578): 3.3 Mb
NC_017046 (Salmonella enterica 798): 1.4 Mb
NC_011147 (Salmonella enterica AKU12601): 1.5 Mb
NC_006511 (Salmonella enterica ATCC 9150): 1.5 Mb
NC_017623 (Salmonella enterica B182): 2.2 Mb
NC_022221 (Salmonella enterica CDC1983-67): 1.2 Mb
NC_021844 (Salmonella enterica CFSAN000189): 2.5 Mb
NC_021814 (Salmonella enterica CFSAN001921): 2.1 Mb
NC_020307 (Salmonella enterica CFSAN001992): 0.9 Mb
NC_021818 (Salmonella enterica CFSAN002050): 2.4 Mb
NC_021812 (Salmonella enterica CFSAN002069): 0.4 Mb
NC_003198 (Salmonella enterica CT18): 1.6 Mb
NC_011205 (Salmonella enterica CT_02021853): 1.9 Mb
NC_011094 (Salmonella enterica CVM19633): 1.4 Mb
NC_016854 (Salmonella enterica D23580): 1.5 Mb
NC_003197 (Salmonella enterica LT2): 1.5 Mb
NC_016832 (Salmonella enterica P-stx-12): 1.3 Mb
NC_011294 (Salmonella enterica P125109): 1.7 Mb
NC_012125 (Salmonella enterica RKS4594): 2.4 Mb
NC_016831 (Salmonella enterica RKS5078): 1.2 Mb
NC_010067 (Salmonella enterica RSK2980): 1.5 Mb
NC_021984 (Salmonella enterica S06004): 1.2 Mb
NC_006905 (Salmonella enterica SC-B67): 1.5 Mb
NC_010102 (Salmonella enterica SGSC4150; SPB7): 1.6 Mb
NC_016810 (Salmonella enterica SL1344): 1.4 Mb
NC_011080 (Salmonella enterica SL254): 1.5 Mb
NC_011083 (Salmonella enterica SL476): 1.5 Mb
NC_011149 (Salmonella enterica SL483): 1.7 Mb
NC_016857 (Salmonella enterica ST4/74): 1.4 Mb
NC_016860 (Salmonella enterica T000240): 1.5 Mb
NC_004631 (Salmonella enterica Ty2): 1.3 Mb
NC_021176 (Salmonella enterica Ty21a): 1.3 Mb
NC_021151 (Salmonella enterica U288): 0.7 Mb
NC_016863 (Salmonella enterica UK-1): 1.4 Mb
NC_021902 (Salmonella enterica USMARC-S3124.1): 2.5 Mb
NC_021741 (Serratia liquefaciens ATCC 27592): 1.0 Mb
NC_009832 (Serratia proteamaculans 568): 1.2 Mb
NC_017571 (Shewanella baltica BA175): 2.8, 2.9 Mb
NC_017579 (Shewanella baltica OS117): 2.4, 2.4 Mb
NC_009052 (Shewanella baltica OS155): 2.3, 2.3 Mb
NC_009997 (Shewanella baltica OS195): 2.7, 2.7 Mb
NC_016901 (Shewanella baltica OS678): 2.6, 2.7 Mb
NC_014012 (Shewanella violacea DSS12): 2.6 Mb
NC_007712 (Sodalis glossinidius morsitans): 2.2 Mb
NC_015224 (Yersinia enterocolitica 105.5R(r)): 0.4 Mb
NC_017564 (Yersinia enterocolitica Y11): 3.7 Mb
NC_005810 (Yersinia pestis 91001): 0.4 Mb
NC_017168 (Yersinia pestis A1122): 0.8 Mb
NC_010159 (Yersinia pestis Angola): 4.2 Mb
NC_008150 (Yersinia pestis Antiqua): 4.5 Mb
NC_003143 (Yersinia pestis CO92): 0.3 Mb
NC_017154 (Yersinia pestis D106004): 0.3 Mb
NC_017160 (Yersinia pestis D182038): 0.3 Mb
NC_017265 (Yersinia pestis Harbin 35): 0.7 Mb
NC_004088 (Yersinia pestis KIM): 0.6 Mb
NC_008149 (Yersinia pestis Nepal516): 3.9 Mb
NC_009381 (Yersinia pestis Pestoides F): 4.2 Mb
NC_014029 (Yersinia pestis Z176003): 0.3 Mb
NC_009708 (Yersinia pseudotuberculosis IP 31758): 4.3 Mb
NC_006155 (Yersinia pseudotuberculosis IP 32953): 0.4 Mb
NC_010634 (Yersinia pseudotuberculosis PB1/+): 0.4 Mb
NC_010465 (Yersinia pseudotuberculosis YPIII): 4.3 Mb