Pathogenicity Island: SPI-1


• General information

Name : SPI-1
Host strain : Salmonella enterica SL1344
Function : Type III secretion system, invasion into epithelial cells, apoptosis (InvA, OrgA, SptP, SipA, SipB, SipC, SipD, SopE, prgH)
Insertion site : fhlA/mutS


• GenBank accessions: 3 records

1) AF148689 (2705 bp)

    Definition : Salmonella typhimurium transcriptional regulator SprA (sprA) and transcriptional regulator SprB (sprB) genes, complete cds.

    Publication :
    - Eichelberg,K., Hardt,W.D. and Galan,J.E., "Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1", Mol. Microbiol. 33 (1), 139-152 (1999) PUBMED 10411731.

    - Eichelberg,K. and Galan,J.E., "Direct Submission", Submitted (05-MAY-1999) Microbial Pathogenesis, Yale School of Medicine, 295 Congress Av., New Haven, CT 06536, USA.


      





2) U16278 (1085 bp)

    Definition : Salmonella typhimurium putative formate hydrogenlyase (fhlA) gene, partial cds, and junction of the 40kb pathogenicity island.

    Publication :
    - Mills,D.M., Bajaj,V. and Lee,C.A., "A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome", Mol. Microbiol. 15 (4), 749-759 (1995) PUBMED 7783645.

    - Lee,C.A., "Direct Submission", Submitted (25-OCT-1994) Catherine A. Lee, Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.


      





3) U16303 (3141 bp)

    Definition : Salmonella typhimurium DNA mismatch repair protein (mutS) gene, complete cds, and right-hand junction of the 40kb pathogenicity island.

    Publication :
    - Mills,D.M., Bajaj,V. and Lee,C.A., "A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome", Mol. Microbiol. 15 (4), 749-759 (1995) PUBMED 7783645.

    - Haber,L.T., Pang,P.P., Sobell,D.I., Mankovich,J.A. and Walker,G.C., "Nucleotide sequence of the Salmonella typhimurium mutS gene required for mismatch repair: homology of MutS and HexA of Streptococcus pneumoniae", J. Bacteriol. 170 (1), 197-202 (1988) PUBMED 3275609.

    - Lee,C.A., "Direct Submission", Submitted (25-OCT-1994) Catherine A. Lee, Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.


      





• PAI-like regions homologous to this PAI (genomes and locations)

None