Pathogenicity Island: cag PAI


• General information

Name : cag PAI
Host strain : Helicobacter pylori OK101
Function : Translocation of CagA, Type IV secretion system, stimulation of IL-8 synthesis
Insertion site : glr (glutamate racemase)


• GenBank accessions: 3 records

1) AB090085 (3519 bp)

    Definition : Helicobacter pylori gene for CagA, complete cds, strain:OK101.

    Publication :
    - Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.

    - Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).


      





2) AB120422 (37021 bp)

    Definition : Helicobacter pylori genes for cag pathogenicity island protein, complete cds, strain:OK101.

    Publication :
    - Azuma,T., Yamakawa,A., Yamazaki,S., Ohtani,M., Ito,Y., Muramatsu,A., Suto,H., Yamazaki,Y., Keida,Y., Higashi,H. and Hatakeyama,M., "Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan", J. Clin. Microbiol. 42 (6), 2508-2517 (2004) PUBMED 15184428.

    - Azuma,T., Yamakawa,A. and Yamazaki,S., "Direct Submission", Submitted (12-SEP-2003) Takeshi Azuma, University of Fukui Faculty of Medical Sciences, General Medicine Second Department of Internal Medicine; Shimoaizuki 23-3, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:8.


      






3) AB191080 (2952 bp)

    Definition : Helicobacter pylori cagE gene for cag pathogenicity island protein E, complete cds, strain:OK101.

    Publication :
    - Yamazaki,S., Yamakawa,A., Okuda,T., Ohtani,M., Suto,H., Ito,Y., Yamazaki,Y., Keida,Y., Higashi,H., Hatakeyama,M. and Azuma,T., "Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan", J. Clin. Microbiol. 43 (8), 3906-3916 (2005) PUBMED 16081930.

    - Yamazaki,S., Yamakawa,A. and Azuma,T., "Direct Submission", Submitted (24-SEP-2004) Takeshi Azuma, University of Fukui, Faculty of Medical Sciences, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).


      





• PAI-like regions homologous to this PAI (genomes and locations)

NC_017374 (Helicobacter pylori 2017): 0.5 Mb
NC_017381 (Helicobacter pylori 2018): 0.5 Mb
NC_000915 (Helicobacter pylori 26695): 0.5 Mb
NC_018939 (Helicobacter pylori 26695): 0.5 Mb
NC_017360 (Helicobacter pylori 35A): 1.0 Mb
NC_017382 (Helicobacter pylori 51): 0.8 Mb
NC_017354 (Helicobacter pylori 52): 0.8 Mb
NC_017375 (Helicobacter pylori 83): 0.9 Mb
NC_017357 (Helicobacter pylori 908): 0.5 Mb
NC_014256 (Helicobacter pylori B8): 0.7 Mb
NC_017358 (Helicobacter pylori Cuz20): 0.6 Mb
NC_017063 (Helicobacter pylori ELS37): 0.8 Mb
NC_017368 (Helicobacter pylori F16): 0.8 Mb
NC_017365 (Helicobacter pylori F30): 0.8 Mb
NC_017366 (Helicobacter pylori F32): 0.5 Mb
NC_017367 (Helicobacter pylori F57): 0.6 Mb
NC_011333 (Helicobacter pylori G27): 0.5 Mb
NC_017371 (Helicobacter pylori Gambia94/24): 0.5 Mb
NC_008086 (Helicobacter pylori HPAG1): 0.5 Mb
NC_017733 (Helicobacter pylori HUP-B14): 0.8 Mb
NC_017372 (Helicobacter pylori India7): 0.8 Mb
NC_000921 (Helicobacter pylori J99): 0.5 Mb
NC_017362 (Helicobacter pylori Lithuania75): 0.5 Mb
NC_020508 (Helicobacter pylori OK113): 0.6 Mb
NC_020509 (Helicobacter pylori OK310): 0.8 Mb
NC_011498 (Helicobacter pylori P12): 0.5 Mb
NC_017742 (Helicobacter pylori PeCan18): 0.5 Mb
NC_014555 (Helicobacter pylori PeCan4): 0.5 Mb
NC_017378 (Helicobacter pylori Puno120): 0.5 Mb
NC_017379 (Helicobacter pylori Puno135): 0.5 Mb
NC_018937 (Helicobacter pylori Rif1): 0.5 Mb
NC_018938 (Helicobacter pylori Rif2): 0.5 Mb
NC_017376 (Helicobacter pylori Santal49): 0.5 Mb
NC_017359 (Helicobacter pylori Sat464): 0.8 Mb
NC_017741 (Helicobacter pylori Shi112): 0.9 Mb
NC_017740 (Helicobacter pylori Shi169): 0.5 Mb
NC_017739 (Helicobacter pylori Shi417): 0.5 Mb
NC_010698 (Helicobacter pylori Shi470): 0.8 Mb
NC_014560 (Helicobacter pylori SJM180): 0.5 Mb
NC_021215 (Helicobacter pylori UM032): 0.9 Mb
NC_021217 (Helicobacter pylori UM037): 0.8 Mb
NC_021218 (Helicobacter pylori UM066): 1.0 Mb
NC_021882 (Helicobacter pylori UM298): 1.5 Mb
NC_021216 (Helicobacter pylori UM299): 0.4 Mb
NC_017355 (Helicobacter pylori v225d): 0.5, 0.5 Mb
NC_017926 (Helicobacter pylori XZ274): 0.9 Mb