Pathogenicity Island: cag PAI


• General information

Name : cag PAI
Host strain : Helicobacter pylori NCTC 11637
Function : Translocation of CagA, Type IV secretion system, stimulation of IL-8 synthesis
Insertion site : glr (glutamate racemase)


• GenBank accessions: 3 records

1) AB191103 (2952 bp)

    Definition : Helicobacter pylori cagE gene for cag pathogenicity island protein E, complete cds, strain:NCTC11637.

    Publication :
    - Yamazaki,S., Yamakawa,A., Okuda,T., Ohtani,M., Suto,H., Ito,Y., Yamazaki,Y., Keida,Y., Higashi,H., Hatakeyama,M. and Azuma,T., "Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan", J. Clin. Microbiol. 43 (8), 3906-3916 (2005) PUBMED 16081930.

    - Yamazaki,S., Yamakawa,A. and Azuma,T., "Direct Submission", Submitted (24-SEP-2004) Takeshi Azuma, University of Fukui, Faculty of Medical Sciences, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).


      





2) AF191010 (589 bp)

    Definition : Helicobacter pylori strain NCTC 11637 cag pathogenicity island polymorphic right end, type IIIa motif.

    Publication :
    - Kersulyte,D., Mukhopadhyay,A.K., Velapatino,B., Su,W.W., Pan,Z.J., Garcia,C., Hernandez,V., Valdez,Y., Mistry,R.S., Gilman,R.H., Yuan,Y., Gao,H., Alarcon,T., Lopez-Brea,M., Balakrish Nair,G., Chowdhury,A., Datta,S., Shirai,M., Nakazawa,T., Ally,R., Segal,, "Differences in genotypes of Helicobacter pylori from different human populations", J. Bacteriol. 182 (11), 3210-3218 (2000) PUBMED 10809702.

    - Kersulyte,D., Mukhopadhyay,A.K., Velapatino,B., Su,W.W., Pan,Z.J. and Berg,D.E., "Direct Submission", Submitted (01-OCT-1999) Molecular Microbiology, Washington University Medical School, 4566 Scott Ave., St. Louis, MO 63110, USA.