Pathogenicity Island: cag PAI


• General information

Name : cag PAI
Host strain : Helicobacter pylori F18
Function : Translocation of CagA, Type IV secretion system, stimulation of IL-8 synthesis
Insertion site : glr (glutamate racemase)


• GenBank accessions: 2 records

1) AB090077 (3720 bp)

    Definition : Helicobacter pylori gene for CagA, complete cds, strain:F18.

    Publication :
    - Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.

    - Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).


      





2) AB191066 (2952 bp)

    Definition : Helicobacter pylori cagE gene for cag pathogenicity island protein E, complete cds, strain:F18.

    Publication :
    - Yamazaki,S., Yamakawa,A., Okuda,T., Ohtani,M., Suto,H., Ito,Y., Yamazaki,Y., Keida,Y., Higashi,H., Hatakeyama,M. and Azuma,T., "Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan", J. Clin. Microbiol. 43 (8), 3906-3916 (2005) PUBMED 16081930.

    - Yamazaki,S., Yamakawa,A. and Azuma,T., "Direct Submission", Submitted (24-SEP-2004) Takeshi Azuma, University of Fukui, Faculty of Medical Sciences, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).


      





• PAI-like regions homologous to this PAI (genomes and locations)

None