Pathogenicity Island: cag PAI


• General information

Name : cag PAI
Host strain : Helicobacter pylori CCUG 17874=NCTC 11638
Function : Translocation of CagA, Type IV secretion system, stimulation of IL-8 synthesis
Insertion site : glr (glutamate racemase)


• GenBank accessions: 3 records

1) AF282852 (21347 bp)

    Definition : Helicobacter pylori cagII pathogenicity island, complete sequence.

    Publication :
    - Censini,S., Lange,C., Xiang,Z., Crabtree,J.E., Ghiara,P., Borodovsky,M., Rappuoli,R. and Covacci,A., "cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors", Proc. Natl. Acad. Sci. U.S.A. 93 (25), 14648-14653 (1996) PUBMED 8962108.

    - Covacci,A. and Rappuoli,R., "Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell", J. Exp. Med. 191 (4), 587-592 (2000) PUBMED 10684850.

    - Censini,S., Rappuoli,R., Lange,C. and Covacci,A., "Direct Submission", Submitted (06-JUN-1996) Molecular Biology, Chiron-Biocine, Via Fiorentina 1, Siena, SI 53100, Italy.

    - Censini,S., Rappuoli,R. and Covacci,A., "Direct Submission", Submitted (17-MAR-2000) Molecular Biology, Chiron-Biocine, Via Fiorentina 1, Siena, SI 53100, Italy REMARK Sequence update by submitter.