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Homologs of dfrA15 gene of JX121641

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) dhfrI
( YP_001715373.1 )

dihydrofolate reductase type 1 (dihydrofolate reductase type I) (trimethoprim resistance protein)

NC_010410
(Acinetobacter baumannii AYE)

3e-66

2) SFxv_4142a
( YP_005729392.1 )

trimethoprim resistance protein,type I dihydrofolate reductase

NC_017328
(Shigella flexneri 2002017)

3e-66

3) ST548_p1188
( YP_007386304.1 )

Dihydrofolate reductase

NC_020180
(Enterobacter aerogenes EA1509E)

6e-66

4) NRG857_30100
( YP_006162239.1 )

dihydrofolate reductase type I DhfrA1

NC_017659
(Escherichia coli NRG 857C)

6e-66

5) A225_R1p0435
( YP_006501701.1 )

Dhfr1

NC_018107
(Klebsiella oxytoca E718)

6e-66

6) dhfrV
( YP_001740004.1 )

dihydrofolate reductase type 5

NC_010488
(Escherichia coli SMS-3-5)

6e-55

7) dhfR
( NP_569370.1 )

dihydrofolate reductase

NC_003384
(Salmonella enterica CT18)

6e-55

8) O3M_00535
( YP_006767792.1 )

dihydrofolate reductase

NC_018650
(Escherichia coli 2009EL-2050)

6e-53

9) O3O_25165
( YP_006781897.1 )

dihydrofolate reductase

NC_018661
(Escherichia coli 2009EL-2071)

6e-53

10) O3K_00505
( YP_006776837.1 )

dihydrofolate reductase

NC_018658
(Escherichia coli 2011C-3493)

6e-53

11) DP0311
( YP_064047.1 )

dihydrofolate reductase, type VII

NC_006138
(Desulfotalea psychrophila LSv54)

1e-51

12) Noca_2312
( YP_923504.1 )

dihydrofolate reductase

NC_008699
(Nocardioides sp. JS614)

5e-18

13) Clole_0608
( YP_004307540.1 )

dihydrofolate reductase

NC_015275
(Clostridium lentocellum DSM 5427)

2e-17

14) folA
( YP_004574294.1 )

dihydrofolate reductase

NC_015635
(Microlunatus phosphovorus NM-1)

8e-17

15) folA
( YP_005847087.1 )

dihydrofolate reductase

NC_017464
(Ignavibacterium album JCM 16511)

7e-16

16) folA
( NP_349605.1 )

dihydrofolate reductase

NC_003030
(Clostridium acetobutylicum ATCC 824)

4e-15

17) dfrA
( YP_004637658.1 )

dihydrofolate reductase

NC_015687
(Clostridium acetobutylicum DSM 1731)

4e-15

18) CEA_G3010
( YP_005672142.1 )

Dihydrofolate reductase

NC_017295
(Clostridium acetobutylicum EA 2018)

4e-15

19) folA
( YP_002773868.1 )

dihydrofolate reductase

NC_012491
(Brevibacillus brevis NBRC 100599)

1e-14

20) LIV_1851
( YP_004855599.1 )

putative dihydrofolate reductase

NC_016011
(Listeria ivanovii PAM 55)

4e-13

21) folA
( YP_006845177.1 )

dihydrofolate reductase

NC_018704
(Amphibacillus xylanus NBRC 15112)

8e-12

• Sequence Alignments

1) dhfrI in NC_010410


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  244 bits (910),  Expect = 3e-66, Method: Compositional matrix adjust.
 Identities = 144/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENVL+FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

2) SFxv_4142a in NC_017328


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  244 bits (910),  Expect = 3e-66, Method: Compositional matrix adjust.
 Identities = 144/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENVL+FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

3) VCD_003671 in NC_012668


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  244 bits (910),  Expect = 3e-66, Method: Compositional matrix adjust.
 Identities = 144/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENVL+FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

4) dfrA1 in NC_016445


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  244 bits (910),  Expect = 3e-66, Method: Compositional matrix adjust.
 Identities = 144/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENVL+FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

5) ST548_p1188 in NC_020180


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  243 bits (905),  Expect = 6e-66, Method: Compositional matrix adjust.
 Identities = 143/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENV++FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

6) NRG857_30100 in NC_017659


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  243 bits (905),  Expect = 6e-66, Method: Compositional matrix adjust.
 Identities = 143/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENV++FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

7) A225_R1p0435 in NC_018107


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  243 bits (905),  Expect = 6e-66, Method: Compositional matrix adjust.
 Identities = 143/157 (92%), Positives = 151/157 (97%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MKLSLM AISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRSSFTS +ENV++FPSI +AL +LK ITDHVIVSGGGEIYKSLID+VDTLHISTIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDVYFPEIPS+FRPVF+QDF SNINYSYQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

8) dhfrV in NC_010488


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  206 bits (766),  Expect = 6e-55, Method: Compositional matrix adjust.
 Identities = 117/157 (75%), Positives = 139/157 (89%), Gaps = 0/157 (0%)

Query  4    LKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  63
            +K+SLMAA +KNGVIG GPDIPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  64   VVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDI  123
            VVTRS+ TS+D+NV+VF SI+EA+++L  +T+HVIVSGGGEIY+  +    TLH+STIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  124  EPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            EPEGDV+FP IP++F  VF Q+F SNINY YQIW+KG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

9) dhfR in NC_003384


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  206 bits (766),  Expect = 6e-55, Method: Compositional matrix adjust.
 Identities = 117/157 (75%), Positives = 139/157 (89%), Gaps = 0/157 (0%)

Query  4    LKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  63
            +K+SLMAA +KNGVIG GPDIPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  64   VVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDI  123
            VVTRS+ TS+D+NV+VF SI+EA+++L  +T+HVIVSGGGEIY+  +    TLH+STIDI
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  124  EPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            EPEGDV+FP IP++F  VF Q+F SNINY YQIW+KG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

10) O3M_00535 in NC_018650


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  199 bits (740),  Expect = 6e-53, Method: Compositional matrix adjust.
 Identities = 112/157 (72%), Positives = 139/157 (89%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A S NGVIGNGPDIPWSAKGEQLLFKA+TYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R +++SS+ENVLVFPSI+ AL++L  ITDH+ VSGGG+IY+SLI+K D +H+ST+++
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP IP +F  VF Q F+SNINY+YQIW+KG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

11) O3O_25165 in NC_018661


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  199 bits (740),  Expect = 6e-53, Method: Compositional matrix adjust.
 Identities = 112/157 (72%), Positives = 139/157 (89%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A S NGVIGNGPDIPWSAKGEQLLFKA+TYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R +++SS+ENVLVFPSI+ AL++L  ITDH+ VSGGG+IY+SLI+K D +H+ST+++
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP IP +F  VF Q F+SNINY+YQIW+KG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

12) O3K_00505 in NC_018658


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  199 bits (740),  Expect = 6e-53, Method: Compositional matrix adjust.
 Identities = 112/157 (72%), Positives = 139/157 (89%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A S NGVIGNGPDIPWSAKGEQLLFKA+TYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R +++SS+ENVLVFPSI+ AL++L  ITDH+ VSGGG+IY+SLI+K D +H+ST+++
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP IP +F  VF Q F+SNINY+YQIW+KG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

13) DP0311 in NC_006138


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  195 bits (724),  Expect = 1e-51, Method: Compositional matrix adjust.
 Identities = 103/156 (67%), Positives = 135/156 (87%), Gaps = 0/156 (0%)

Query  1    MKISLMAAKSENGVIGKGADIPWMVKGEQLLFKAITFNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SLMAA S NGVIG+G+DIPW  KGEQLLFKAIT+NQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VITRSGLLSQNDNVLVFPSIEDALRELAQQTEHIIVAGGGEIFKAMINRADTLHLSTVHQ  120
            V+TRS++ S ++NVLVFPSI++AL +L   T+H+IV+GGGEI+K++I++ DTLH+ST++ 
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  NIDGDITFPQVPKDFKLVFEQYFESNINYTYQIWQR  156
            + +GD+ FP++P  F+ VF Q F SNINY+YQIWQ+
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQK  156

14) VS_1884 in NC_011753


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score =  178 bits (660),  Expect = 2e-46, Method: Compositional matrix adjust.
 Identities = 102/157 (65%), Positives = 132/157 (85%), Gaps = 0/157 (0%)

Query  27   LKLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKLPNRKYA  86
            +KLSLMAA++ NGVIG+G DIPW  KGEQLLFKA+T+NQWLL+GRKTFESMG LPNRKYA
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60

Query  87   VISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTihiskihk  146
            V++RS+ TS+D ++L F S+++AL  L T+T+H +VSGGG+IYKSLI +VDT+HIS I+ 
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  147  hisGDIFFPELPRDLTLVFEQRFSSNIDYTYQIWQKG  183
            +  GD++FPE+P  +  VF Q F SNI+Y+YQIWQKG
Sbjct  121  EPEGDVYFPEIPSSFRPVFSQDFVSNINYSYQIWQKG  157

15) Noca_2312 in NC_008699


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 83.9 bits (299),  Expect = 5e-18, Method: Compositional matrix adjust.
 Identities = 56/131 (43%), Positives = 90/131 (69%), Gaps = 2/131 (1%)

Query  6    KRVVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTT  65
             ++ L+AA+++NGVIG+GPDIPW   GEQ LFK++T  + L++GR T++S+G +LP R  
Sbjct  1    MKLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKY  59

Query  66   IVLTRSP-DWSAEGvhvahdlpaalaladTLEGEVMVAGGGQVYAAALPVADEQVLSEVD  124
             V+TRS+   S E V V   +  AL    T+ ++V+V+GGG++Y + +   D   +S +D
Sbjct  60   AVVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTID  119

Query  125  LEPQGDAFYPE  135
            +EP+GD ++PE
Sbjct  120  IEPEGDVYFPE  130

16) Clole_0608 in NC_015275


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 81.8 bits (291),  Expect = 2e-17, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 87/136 (64%), Gaps = 2/136 (1%)

Query  1    MICLIAAVSKNNQIGLHNQMPWHIPEDLAYFREVTSGHTVIMGRKTFESIGKPLPHRTNM  60
             + L+AA+SKN  IG   ++PW    +   F+ +T  + +++GRKTFES+G +LP+R   
Sbjct  2    KLSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYA  60

Query  61   VLTTNP-NFSAEGVVVLHSLNEALELCKTTTEAVFVIGGGEIYKAFLPFAEYLYITLIDE  119
            V+T ++   S E V+V+ S++EAL+  KT T+ V+V GGGEIYK+++   + L I+ ID 
Sbjct  61   VVTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  120  VVEGDTCFPDYQKDFQ  135
              EGD  FP+    F+
Sbjct  121  EPEGDVYFPEIPSSFR  136

17) folA in NC_015635


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 80.0 bits (284),  Expect = 8e-17, Method: Compositional matrix adjust.
 Identities = 54/132 (41%), Positives = 90/132 (69%), Gaps = 3/132 (2%)

Query  4    IAAVARNGVIGAGNDIPWRIKEDWARFKAITMGHVLIMGRKTYDSIGRPLPGRTTIVVTR  63
            +AA+++NGVIG G DIPW  K +   FKAIT  + L++GRKT++S+G +LP R   VVTR
Sbjct  6    MAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAVVTR  64

Query  64   DP-DWTADGIRTAHNLDDAFEVAYALAPEKVFVAGGGQIYAAAWDRLDVLEITEVDIEPA  122
             +   + + +    ++D+A++   +++ + V+V+GGG+IY +  D++D L+I+ +DIEP 
Sbjct  65   SSFTSSDENVLVFPSIDEALNHLKTIT-DHVIVSGGGEIYKSLIDKVDTLHISTIDIEPE  123

Query  123  GEVRFPLIGPEW  134
            G+V FP I +  
Sbjct  124  GDVYFPEIPSSF  135

18) folA in NC_017464


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 76.5 bits (271),  Expect = 7e-16, Method: Compositional matrix adjust.
 Identities = 56/138 (41%), Positives = 94/138 (69%), Gaps = 4/138 (2%)

Query  1    MIISLIVAIAQNGVIGKSSGEMSWHVSEEFKHFKNTTKGFPVLMGRKTFETLGKPLKERL  60
            M +SL+ AI++NGVIG+++ +++W    E   FK  T    +L+GRKTFE++G +L +R 
Sbjct  1    MKLSLMAAISKNGVIGNGP-DIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRK  58

Query  61   NIVLTRNPEYKTQFDDVLIFSSLDEAINFCREKKFEKIFIIGGAEIYKIAIPIVDEMIIS  120
              V+TR++ + +  ++VL+F+S+DEA+N  +    + +++ GG+EIYK  I  VD + IS
Sbjct  59   YAVVTRSS-FTSSDENVLVFPSIDEALNHLKTIT-DHVIVSGGGEIYKSLIDKVDTLHIS  116

Query  121  RMKFTAEGDVYFPEFDES  138
             + + +EGDVYFPE+  S
Sbjct  117  TIDIEPEGDVYFPEIPSS  134

19) folA in NC_003030


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 74.2 bits (262),  Expect = 4e-15, Method: Compositional matrix adjust.
 Identities = 52/128 (41%), Positives = 84/128 (66%), Gaps = 3/128 (2%)

Query  2    LSIIAALNENYVIGNENKLIWHISDDLKRFKKLTTGKTIIMGRKTFESLPGVLPNRKHIV  61
            LS++AA++ N VIGN   + W   ++   FK +T  + +++GRKTFES+ G LPNRK  V
Sbjct  3    LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESM-GALPNRKYAV  61

Query  62   ITK-NLNYSRENVSIVHSIDEIIE-LKDTTEENFIIGGGEIYRALIPYCSILYLTKVHSN  119
            +T+ ++  S ENV +  SIDE ++ LK  T++ ++ GGGEIY++LI     L ++ ++ +
Sbjct  62   VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE  121

Query  120  QTGDAFFP  127
              GD +FP
Sbjct  122  PEGDVYFP  129

20) dfrA in NC_015687


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 74.2 bits (262),  Expect = 4e-15, Method: Compositional matrix adjust.
 Identities = 52/128 (41%), Positives = 84/128 (66%), Gaps = 3/128 (2%)

Query  2    LSIIAALNENYVIGNENKLIWHISDDLKRFKKLTTGKTIIMGRKTFESLPGVLPNRKHIV  61
            LS++AA++ N VIGN   + W   ++   FK +T  + +++GRKTFES+ G LPNRK  V
Sbjct  3    LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESM-GALPNRKYAV  61

Query  62   ITK-NLNYSRENVSIVHSIDEIIE-LKDTTEENFIIGGGEIYRALIPYCSILYLTKVHSN  119
            +T+ ++  S ENV +  SIDE ++ LK  T++ ++ GGGEIY++LI     L ++ ++ +
Sbjct  62   VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE  121

Query  120  QTGDAFFP  127
              GD +FP
Sbjct  122  PEGDVYFP  129

21) CEA_G3010 in NC_017295


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 74.2 bits (262),  Expect = 4e-15, Method: Compositional matrix adjust.
 Identities = 52/128 (41%), Positives = 84/128 (66%), Gaps = 3/128 (2%)

Query  2    LSIIAALNENYVIGNENKLIWHISDDLKRFKKLTTGKTIIMGRKTFESLPGVLPNRKHIV  61
            LS++AA++ N VIGN   + W   ++   FK +T  + +++GRKTFES+ G LPNRK  V
Sbjct  3    LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESM-GALPNRKYAV  61

Query  62   ITK-NLNYSRENVSIVHSIDEIIE-LKDTTEENFIIGGGEIYRALIPYCSILYLTKVHSN  119
            +T+ ++  S ENV +  SIDE ++ LK  T++ ++ GGGEIY++LI     L ++ ++ +
Sbjct  62   VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE  121

Query  120  QTGDAFFP  127
              GD +FP
Sbjct  122  PEGDVYFP  129

22) folA in NC_012491


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 72.6 bits (256),  Expect = 1e-14, Method: Compositional matrix adjust.
 Identities = 52/129 (41%), Positives = 86/129 (67%), Gaps = 9/129 (6%)

Query  2    ISLIVAYARNQVIGKDGDMPWHLPADLKNVKELTTGKTIVMGRKTFESIGKPLPNRRNVV  61
            +SL+ A ++N VIG++ D+PW   ++    K +T  + +++GRKTFES+G +LPNR+  V
Sbjct  3    LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV  61

Query  62   LTRSQDFHPEGVDVV--HTKEEVLA-----MGDVIIFGGSEIYRQFLDVVDRLYITEIDL  114
            +TRS  F + + +V+   + +E L       ++VI+ GG+EIY+ ++D VD L I+ ID+
Sbjct  62   VTRS-SFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  115  ETEGDTFFP  123
            E EGD +FP
Sbjct  121  EPEGDVYFP  129

23) LIV_1851 in NC_016011


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 67.6 bits (237),  Expect = 4e-13, Method: Compositional matrix adjust.
 Identities = 51/124 (42%), Positives = 78/124 (63%), Gaps = 5/124 (4%)

Query  9    DRDGNIGKANKMPWYLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIVLTRDKEL  68
             ++G IG++  +PW   G+  +FK  T  + L++GRKT+ES+G ALPNRK  V+TR   +
Sbjct  10   SKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAVVTRS-SF  67

Query  69   HLSDAEVL--HSRDEVLD-LANTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFDADTA  125
              SD +VL   S DE L+ L    + + V GG+EIY+ ++D  D L ++ ID E ++D  
Sbjct  68   TSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIEPEGDVY  127

Query  126  FPEV  129
            FPE+
Sbjct  128  FPEI  131

24) folA in NC_018704


> JX121641|90|G53|481190490|AGK07099.1|Proteus_mirabilis_PmGUE|+|52261..52734|dfrA15|-|DfrA15 
dihydrofolate reductase
Length=157

 Score = 63.4 bits (221),  Expect = 8e-12, Method: Compositional matrix adjust.
 Identities = 54/131 (42%), Positives = 79/131 (61%), Gaps = 3/131 (2%)

Query  2    LSMIFANDKNYLIGKDNWIPWDIPNDLGFFKAMTTGKTIIMGRKTFESFKKPLPNRHHVV  61
            LS++ A  KN +IG++  IPW    +  +FKA+T  + +++GRKTFES   +LPNR   V
Sbjct  3    LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFES-MGALPNRKYAV  61

Query  62   LTRNR-DFKAEGCDVFHHIDDVLAYIKQFEDQEVIVIGGAEIYVQFFPYADRLYITYIDH  120
            +TR+      E   VF  ID+ L  +K + D+ VIV GG+EIY  ++   D L I+ ID 
Sbjct  62   VTRSSFTSSDENVLVFPSIDEALNHLKTITDH-VIVSGGGEIYKSLIDKVDTLHISTIDI  120

Query  121  EFEGDTHLPKF  131
            E EGD  +P +
Sbjct  121  EPEGDVYFPEI  131