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Homologs of vanB gene of NC_021994_R1

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) vanB
( YP_008394259.1 )

Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase

NC_021994
(Enterococcus faecium AUS0085)

2e-160

100

2) vanB
( YP_005355973.1 )

Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase

NC_017022
(Enterococcus faecium Aus0004)

5e-159

3) vanB
( NP_815951.1 )

D-alanine--D-lactate ligase

NC_004668
(Enterococcus faecalis V583)

3e-153

4) vanB
( YP_001511364.1 )

D-alanine--D-lactate ligase

NC_009921
(Frankia sp. EAN1.pec)

8e-112

5) vanB
( YP_519923.1 )

D-alanine--D-lactate ligase

NC_007907
(Desulfitobacterium hafniense Y51)

3e-111

6) vanB
( NP_627790.1 )

D-alanine--D-lactate ligase

NC_003888
(Streptomyces coelicolor A3(2))

1e-110

7) vanB
( YP_002458146.1 )

D-alanine--D-lactate ligase

NC_011830
(Desulfitobacterium hafniense DCB-2)

8e-110

8) Tpau_0523
( YP_003645503.1 )

D-alanine--D-alanine ligase

NC_014158
(Tsukamurella paurometabola DSM 20162)

3e-109

9) Kfla_3620
( YP_003381476.1 )

D-alanine/D-alanine ligase

NC_013729
(Kribbella flavida DSM 17836)

1e-108

10) Desdi_1473
( YP_007220364.1 )

D-alanine--D-alanine ligase

NC_019903
(Desulfitobacterium dichloroeliminans LMG P-21439)

3e-106

11) Snas_5356
( YP_003514082.1 )

D-alanine--D-alanine ligase

NC_013947
(Stackebrandtia nassauensis DSM 44728)

3e-106

12) BN6_49760
( YP_007039118.1 )

putative D-alanine-D-lactate ligase

NC_019673
(Saccharothrix espanaensis DSM 44229)

7e-104

13) ddlA
( YP_008464492.1 )

D-alanine-D-alanine ligase

NC_022116
(Amycolatopsis mediterranei RB)

2e-103

14) vanB
( YP_005536437.1 )

D-alanine--D-lactate ligase

NC_017186
(Amycolatopsis mediterranei S699)

2e-103

15) ddlA
( YP_006554640.1 )

D-alanine-D-alanine ligase

NC_018266
(Amycolatopsis mediterranei S699)

2e-103

16) ddlA
( YP_003770389.1 )

D-alanine--D-alanine ligase

NC_014318
(Amycolatopsis mediterranei U32)

2e-103

17) vanB
( YP_003116492.1 )

D-alanine--D-lactate ligase

NC_013131
(Catenulispora acidiphila DSM 44928)

4e-102

18) ddl
( YP_008010463.1 )

D-alanine-D-alanine ligase

NC_021252
(Amycolatopsis orientalis HCCB10007)

6e-101

19) Cwoe_1414
( YP_003393217.1 )

D-alanine--D-alanine ligase

NC_013739
(Conexibacter woesei DSM 14684)

2e-100

20) CLS_04660
( YP_007848286.1 )

D-alanine--D-alanine ligase

NC_021047
(Clostridium saccharolyticum K10)

6e-71

21) OBV_09510
( YP_004880655.1 )

putative D-alanine--D-lactate ligase

NC_016048
(Oscillibacter valericigenes Sjm18-20)

4e-70

22) Desgi_1749
( YP_007944883.1 )

D-alanine--D-alanine ligase

NC_021184
(Desulfotomaculum gibsoniae DSM 7213)

1e-68

23) Clos_2860
( YP_001514385.1 )

D-alanine--D-alanine ligase

NC_009922
(Alkaliphilus oremlandii OhILAs)

1e-65

24) Clo1100_2030
( YP_005148027.1 )

D-alanine--D-alanine ligase

NC_016791
(Clostridium sp. BNL1100)

2e-65

25) BBR47_05870
( YP_002770068.1 )

ligase

NC_012491
(Brevibacillus brevis NBRC 100599)

3e-64

26) RBR_17480
( YP_007781707.1 )

D-alanine--D-alanine ligase

NC_021013
(Ruminococcus bromii L2-63)

8e-63

27) vanG
( YP_006787428.1 )

D-alanine-D-serine ligase VanG

NC_018664
(Clostridium acidurici 9a)

2e-62

28) vanG
( YP_001088127.1 )

D-alanyl-alanine synthetase A

NC_009089
(Clostridium difficile 630)

7e-60

29) vanG
( YP_003214576.1 )

D-alanine:D-alanine ligase

NC_013315
(Clostridium difficile CD196)

7e-60

30) vanG
( YP_003218020.1 )

vancomycin/teicoplanin A-type resistance protein

NC_013316
(Clostridium difficile R20291)

7e-60

31) Clole_1511
( YP_004308435.1 )

D-alanine/D-alanine ligase

NC_015275
(Clostridium lentocellum DSM 5427)

8e-60

32) Ethha_0761
( YP_004091061.1 )

D-alanine--D-alanine ligase

NC_014828
(Ethanoligenens harbinense YUAN-3)

1e-59

33) ddl
( YP_002573889.1 )

D-alanyl-alanine synthetase A

NC_012034
(Caldicellulosiruptor bescii DSM 6725)

2e-59

34) Calhy_0717
( YP_003991823.1 )

d-alanine/d-alanine ligase

NC_014652
(Caldicellulosiruptor hydrothermalis 108)

4e-59

35) Calkro_0619
( YP_004023332.1 )

d-alanine/d-alanine ligase

NC_014720
(Caldicellulosiruptor kronotskyensis 2002)

4e-59

36) Csac_1372
( YP_001180165.1 )

D-alanyl-alanine synthetase A

NC_009437
(Caldicellulosiruptor saccharolyticus DSM 8903)

5e-59

37) COB47_1809
( YP_003841071.1 )

D-alanine--D-alanine ligase

NC_014392
(Caldicellulosiruptor obsidiansis OB47)

6e-59

38) Calow_1724
( YP_004003062.1 )

d-alanine/d-alanine ligase

NC_014657
(Caldicellulosiruptor owensensis OL)

1e-58

39) Calkr_0526
( YP_004025687.1 )

d-alanine/d-alanine ligase

NC_014721
(Caldicellulosiruptor kristjanssonii 177R1B)

2e-58

40) Calla_1828
( YP_004799387.1 )

D-alanine--D-alanine ligase

NC_015949
(Caldicellulosiruptor lactoaceticus 6A)

2e-58

41) Tthe_0219
( YP_003850878.1 )

D-alanine/D-alanine ligase

NC_014410
(Thermoanaerobacterium thermosaccharolyticum DSM 571)

2e-56

42) Thethe_00207
( YP_007297637.1 )

D-alanine--D-alanine ligase

NC_019970
(Thermoanaerobacterium thermosaccharolyticum M0795)

2e-56

43) Tsac_0772
( YP_006391393.1 )

D-alanine--D-alanine ligase

NC_017992
(Thermoanaerobacterium saccharolyticum JW/SL-YS485)

5e-56

44) Tmath_2122
( YP_003677805.1 )

D-alanine/D-alanine ligase

NC_014209
(Thermoanaerobacter mathranii A3)

7e-55

45) ddl
( YP_001038349.1 )

D-alanyl-alanine synthetase A

NC_009012
(Clostridium thermocellum ATCC 27405)

3e-54

46) Clo1313_2609
( YP_005689060.1 )

D-alanine--D-alanine ligase

NC_017304
(Clostridium thermocellum DSM 1313)

4e-54

47) PALO_04270
( YP_007870828.1 )

D-alanine--D-alanine ligase

NC_021064
(Propionibacterium avidum 44067)

6e-53

48) ddl
( YP_276049.1 )

D-alanyl-alanine synthetase A

NC_005773
(Pseudomonas syringae 1448A)

9e-52

49) Olsu_1201
( YP_003801187.1 )

D-alanine--D-alanine ligase

NC_014363
(Olsenella uli DSM 7084)

8e-51

50) ddl
( YP_236987.1 )

D-alanyl-alanine synthetase A

NC_007005
(Pseudomonas syringae B728a)

3e-50

51) ddl
( NP_103309.1 )

D-alanyl-alanine synthetase A

NC_002678
(Mesorhizobium loti MAFF303099)

1e-49

52) Mesau_03231
( YP_007304976.1 )

D-alanine--D-alanine ligase

NC_019973
(Mesorhizobium australicum WSM2073)

1e-45

53) EC1_04100
( YP_007797708.1 )

D-alanine--D-alanine ligase

NC_021019
(Eubacterium cylindroides T2-87)

3e-43

54) ddl
( YP_002018485.1 )

D-alanyl-alanine synthetase A

NC_011060
(Pelodictyon phaeoclathratiforme BU-1)

1e-41

55) ddl
( YP_001505490.1 )

D-alanyl-alanine synthetase A

NC_009921
(Frankia sp. EAN1.pec)

8e-40

56) ddl
( YP_005192.1 )

D-alanyl-alanine synthetase A

NC_005835
(Thermus thermophilus HB27)

9e-39

57) ddl
( YP_144853.1 )

D-alanyl-alanine synthetase A

NC_006461
(Thermus thermophilus HB8)

2e-34

58) TtJL18_0458
( YP_006058153.1 )

D-alanine--D-alanine ligase

NC_017587
(Thermus thermophilus JL-18)

3e-34

59) Ththe16_1607
( YP_005641130.1 )

D-alanine--D-alanine ligase

NC_017272
(Thermus thermophilus SG0.5JP17-16)

4e-34

• Sequence Alignments

1) vanB in NC_021994


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  558 bits (2107),  Expect = 2e-160, Method: Compositional matrix adjust.
 Identities = 342/342 (100%), Positives = 342/342 (100%), Gaps = 0/342 (0%)

Query  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60
            MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120
            ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180
            CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240
            TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300
            RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342
            VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

2) vanB in NC_017022


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  553 bits (2088),  Expect = 5e-159, Method: Compositional matrix adjust.
 Identities = 341/342 (99%), Positives = 341/342 (99%), Gaps = 0/342 (0%)

Query  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60
            MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKCGEDGAIQGLFVLSGIPYVG  120
            ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGK GEDGAIQGLFVLSGIPYVG
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180
            CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240
            TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300
            RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342
            VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

3) vanB in NC_004668


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  534 bits (2016),  Expect = 3e-153, Method: Compositional matrix adjust.
 Identities = 326/342 (96%), Positives = 335/342 (98%), Gaps = 0/342 (0%)

Query  1    MNKIKVAIIFGGCSEEHDVSVKSAIEIAANINTEKFDPHYIGITKNGVWKLCKKPCTEWE  60
            MN+IKVAIIFGGCSEEHDVSVKSAIEIAANI+TEKFDPHYIGITKNGVWKLCKKPCTEWE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   ADSLPAIFSPDRKTHGLLVMKEREYETRRIDVAFPVLHGKCGEDGAIQGLFELSGIPYVG  120
            ADSLPAI+SPDRKTHGLLVMKE EYETRRIDVAFPVLHGK GEDGAIQGLF LSGIPYVG
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIEKGDKPEARTLTYPVFVKPARSGSSFGV  180
            CDIQSSAACMDKSLAYILTKNAGIAVPEFQ+I+KGDKPEA +LTYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  181  TKVNSTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240
            TKVN+TEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  241  RIHQENEPEKGSENAMIIVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300
            RIHQENEPEKGSENAMI VPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  301  VLNEVNTLPGFTSYSRYPRMAAAAGITLPALIDSLITLAIER  342
            VLNEVNT+PGFTSYSRYPRM AAAGITLPALIDSLITLA+ R
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

4) vanB in NC_009921


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  396 bits (1491),  Expect = 8e-112, Method: Compositional matrix adjust.
 Identities = 221/341 (65%), Positives = 287/341 (85%), Gaps = 1/341 (0%)

Query  1    MDRLRIGIIFGGRSEEHPVSVRSAQEIAKNIDAEKYEPFYIGIARSGAWKLCERPDENWE  60
            M+R++++IIFGG SEEH VSV+SA EIA NID+EK++P YIGI+++G WKLC +P  +WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGSCRPAVLSPDRSVHGLLVLEQGRYETISLDLALPVLHGRLGEDGAMQGLLELSGIPYV  120
             +S  PA+LSPDR  HGLLV+ ++ YET  +D+A+PVLHG++GEDGA+QGL+ LSGIPYV
Sbjct  61   ADS-LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDVQSSALCMDKSLAYTVARGAGIATPNFWTVTANEKVDADLLTYPVFVKPARSGSSFG  180
            GCD+QSSA CMDKSLAY +++ AGIA P+F  +   +K +A+ LTYPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  VSKVSRKEELSGAVDTARQYDSKVLIEEAVVGSEVGCALLGNDLDLTAGEVDRISLSHGF  240
            V+KV+  EEL++A+++A QYD+K+LIE+A+ G EVGCA++GN+ DL  GEVD+I LSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQESAPESGSENSTAIVPADISAEARSLVQETAKAVYRALGCRGLSRVDMFLQEDGK  300
            FRIHQE+ PE GSEN+   VPADI+ E R+ VQETAK VYR LGCRGL+RVD+FLQEDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VVLNEVNTLPGMTSYSRYPRMMAAAGLPLAEVIDRLVSLTL  341
            +VLNEVNT+PG TSYSRYPRM+AAAG+ L+ +ID L++L+L
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

5) vanB in NC_007907


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  395 bits (1484),  Expect = 3e-111, Method: Compositional matrix adjust.
 Identities = 225/342 (66%), Positives = 288/342 (85%), Gaps = 1/342 (0%)

Query  1    MDRLKIAIIFGGCSEEHPVSVKSAGEVAKNLDLDKYEPFYIGITKNGVWQLCRYPEANWE  60
            M+R+K+AIIFGGCSEEH VSVKSA E+A N+D +K++P YIGITKNGVW+LC+ P ++WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGICPSVILSPDRSLQGLLVLEQGQYKTIPLDLVFPVLHGKFGEDGAVQGLLELSGIPYV  120
             +  P+ ILSPDR  +GLLV+ +++Y T  +D+ FPVLHGKFGEDGA+QGL+ LSGIPYV
Sbjct  61   ADSLPA-ILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDIPSSALCMDKSLAYIVAGNAGIATPKFRTVTAKEAIDAERLAYPVYVKPARSGSSFG  180
            GCDI SSA CMDKSLAYI++ NAGIA P F+ +   +  +A  L+YPV+VKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  VTKVCRQEELLSAVAIASQYDSKVLIEEAVIGTEVGCAIFGNDLDLMAGEVDQIRLSHGF  240
            VTKV   EEL +A+  A+QYD+K+LIE+A+ G EVGCA+ GN+ DL+ GEVDQIRLSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQENEPEKGSENSTLIVPADISPQARSRVQETAKAIYRALGCKGLARVDMFLKEDGE  300
            FRIHQENEPEKGSEN+ + VPADI+ + R+RVQETAK +YR LGC+GLARVD+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VILNEVNTLPGMTSYSRFPRMMAAAGLPFAEVIDRLVSLALQ  342
            ++LNEVNT+PG TSYSR+PRM+AAAG+ ++ +ID L++LAL+
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

6) vanB in NC_003888


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  393 bits (1477),  Expect = 1e-110, Method: Compositional matrix adjust.
 Identities = 219/342 (65%), Positives = 283/342 (83%), Gaps = 1/342 (0%)

Query  1    MARLKVGIVFGGSSEEHAVSVKSAQEVARNLDTEKYQPFFVGITKDGAWRLCDGPGQDWE  60
            M R+KV+I+FGG SEEH VSVKSA E+A N+DTEK++P ++GITK+G W+LC  P  +WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGDCRPVVLSPDRSVHGLLVLEQGQYRSVRLDVVLPVLHGTLGEDGATQGLLELSGIPYV  120
             +D  P +LSPDR  HGLLV+ +++Y + R+DV +PVLHG +GEDGA QGL+ LSGIPYV
Sbjct  61   -ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDVQSSALCMDKSLAYVVARSAGIATPDFWTVTGDETIDPGRLTYPVFVKPARSGSSFG  180
            GCD+QSSA CMDKSLAY+++++AGIA P+F  +  ++  ++G LTYPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  VSKVCRPEDLATAVESARRYDTKVLIEAAVVGSEVGCAILGNDPDLIVGEVDRIALSHGF  240
            V+KV   E+L +A+E+A +YD K+LIE A+ G EVGCA++GN+ DLIVGEVD+I LSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQEEQPENGSENSTPVVPADIPTEKRSLVQETAKAVYRALGCRGLSRVDMFLKEDGE  300
            FRIHQE++PE+GSEN+   VPADIP E R+ VQETAK VYR LGCRGL+RVD+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VVLNEVNTLPGMTSYSRYPRMMAAAGLPLSEVIDRTLSLALT  342
            +VLNEVNT+PG TSYSRYPRM+AAAG+ L+ +ID  ++LAL 
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

7) vanB in NC_011830


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  390 bits (1466),  Expect = 8e-110, Method: Compositional matrix adjust.
 Identities = 225/341 (66%), Positives = 285/341 (84%), Gaps = 1/341 (0%)

Query  1    MSKLKIAIIFGGCSEEHPVSVKSAGEVAKNLDLEKYEPFYIGITKDGVWQLCHYPEANWE  60
            M+++K+AIIFGGCSEEH VSVKSA E+A N+D EK++P YIGITK+GVW+LC  P ++WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   KGSCRPAILSPDRSVQGLLVLEQGQYQRIPLDLVFPVLHGKFGEDGAIQGLLELSGIPYV  120
             +   PAILSPDR  +GLLV+ +++Y+   +D+ FPVLHGKFGEDGAIQGL+ LSGIPYV
Sbjct  61   -ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDIPSSALCMDKSLAYIVAGKAGIATPKFRTVTAKETIDAERLAYPVYVKPARSGSSFG  180
            GCDI SSA CMDKSLAYI++ +AGIA P F+ +   +  +A  L+YPV+VKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  VTKVCRQEELLSAVEIARQYDSKVLIEEAVVGSEVGCAIFGNDLDLMAGEVDQICLSHGF  240
            VTKV   EEL +A+E A QYD+K+LIE+A+ G EVGCA+ GN+ DL+ GEVDQI LSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQENEPEKGSENSTLIVPADISPEARSRVQETAKAIYRALGCRGLARVDMFLKEDGT  300
            FRIHQENEPEKGSEN+ + VPADI+ E R+RVQETAK +YR LGCRGLARVD+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VILNEVNTLPGMTSYSRFPRMMAAAGLPFAEVIDRLVSLAF  341
            ++LNEVNT+PG TSYSR+PRM+AAAG+ ++ +ID L++LA+
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

8) Tpau_0523 in NC_014158


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  388 bits (1459),  Expect = 3e-109, Method: Compositional matrix adjust.
 Identities = 206/339 (61%), Positives = 278/339 (83%), Gaps = 0/339 (0%)

Query  1    MSRIRIGVLFGGASEEHPVSVKSAREVARNLDPDRYEAHWIGITRDGAWRLCAGPENDWE  60
            M+RI+++++FGG SEEH VSVKSA E+A N+D +++++H IGIT++G W+LC  P  +WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   SGSVPAMLSPDRGDHGLLVREAGRYRVVELDVILPVLHGRFGEDGAVQGLCELSGVDYIG  120
            ++S+PA+LSPDR  HGLLV   + Y    +DV +PVLHG+FGEDGA+QGL  LSG+ Y+G
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  121  CDVPSSAICMDKSLAYVISSAAGIATPEFRIVAGHEAPDPAELAYPVFVKPARSGSSFGV  180
            CD+ SSA CMDKSLAY+++  AGIA PEF+I+   + P+++ L+YPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  181  SKVTAPDDLPAAIEAAREYDSKVLIERAVAGSEVGCAVLGDGRGLTVGEVDHIALSHGFF  240
            +KV + ++L AAIEAA +YD+K+LIE+A++G EVGCAV+G+  +L VGEVD+I LSHG+F
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  241  RIHQEDSPETGSENSTPIVPADIPAESRARVQQTARAIYRALGCSGLARVDMFLTPGGEV  300
            RIHQE+ PE GSEN+   VPADIP E R RVQ+TA+ +YR LGC GLARVD+FL  +G +
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  301  VLNEVNTLPGLTSYSRYPRMMSAAGISLAEVLDRLVCLT  339
            VLNEVNT+PG+TSYSRYPRM++AAGI+L+ ++D L+ L+
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLA  339

9) Kfla_3620 in NC_013729


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  386 bits (1451),  Expect = 1e-108, Method: Compositional matrix adjust.
 Identities = 212/339 (63%), Positives = 280/339 (83%), Gaps = 2/339 (0%)

Query  1    MKIGILFGGVSEEHPISLKSAREVARSLDPERYEPYYVGITRGGAWMLCDGPDDDWENGT  60
            +K++I+FGG SEEH +S+KSA E+A ++D E+++P Y+GIT+ G W LC  P  +WE ++
Sbjct  4    IKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWEADS  63

Query  61   GRPAVLSPDRTVHGLLVLEQGRYETIRLDVVLPVLHGRLGEDGAIQGLLELSGIPYVGCD  120
              PA+LSPDR  HGLLV+ ++ YET R+DV +PVLHG++GEDGAIQGL+ LSGIPYVGCD
Sbjct  64   -LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCD  122

Query  121  IPSSALCMDKSLAYVVARSAGIATPNFWTVAAKELPDA-DLTYPVFVKPARSGSSFGVSK  179
            I SSA CMDKSLAY+++++AGIA P+F  +   + P+A  LTYPVFVKPARSGSSFGV+K
Sbjct  123  IQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTK  182

Query  180  VTQADDLPSAVEVASQYDSKVLIEQAVVGREIGCAVLGNGGDLVVGEVDHIALSHGFFRI  239
            V  +++L +A+E A+QYD+K+LIEQA+ G E+GCAV+GN +DL+VGEVD+I LSHG+FRI
Sbjct  183  VNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRI  242

Query  240  HQESEPESGSDNSTAIVPADIPAASRTLVRDTAKAVYRALGCGGLARVDLFLTEDGAVVL  299
            HQE+EPE GS+N+   VPADIP   R  V++TAK VYR LGC GLARVDLFL EDG++VL
Sbjct  243  HQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVL  302

Query  300  NEVNTLPGLTSYSRYPRMMAAAGLSMGEVIDRVVSLALT  338
            NEVNT+PG+TSYSRYPRM+AAAG+++  +ID +++LAL 
Sbjct  303  NEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

10) Desdi_1473 in NC_019903


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  378 bits (1421),  Expect = 3e-106, Method: Compositional matrix adjust.
 Identities = 220/341 (65%), Positives = 279/341 (82%), Gaps = 1/341 (0%)

Query  16   MNRLKIAIIFGGCSEEHSVSVKSAQEVAKNLDLEKYEPYYIGITQNGVWKLCHFPEANWE  75
            MNR+K+AIIFGGCSEEH VSVKSA E+A N+D EK++P YIGIT+NGVWKLC  P ++WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  76   NSCCLPAMLAPDSGVHGLIVLEQGKYKMIPLDMVFPVLHGKFGEDGAIQGLLELSCIPYV  135
                LPA+L+PD   HGL+V+ ++ Y    +D+ FPVLHGKFGEDGAIQGL+ LS IPYV
Sbjct  61   ADS-LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  136  GCDIQSSALSMDKSLAYIVAGNARIATPNFWTFTENEDMDPDRFIYPVFVKPARSGSSFG  195
            GCDIQSSA  MDKSLAYI++ NA IA P+F  +   +  +++ + YPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  196  VTKVCREEELLSAVEIARQYDSKVLIEEAVVGSEVGCAIFGDDPDLTAGEVDQISLSHGF  255
            VTKV   EEL +A+E A QYD+K+LIE+A+ G EVGCA+ G++ DL  GEVDQI LSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  256  FRIHQESEPENGSENSTIIVPADISTEMRLHIQETAKAIYRALGCRGLARVDMFLKEDGE  315
            FRIHQE+EPE+GSEN+ I VPADI+ E R ++QETAK +YR LGCRGLARVD+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  316  VILNEVNTLPGMTSYSRFPRMMAAAGLTFAEVIDRIVALTL  356
            ++LNEVNT+PG TSYSR+PRM+AAAG+T++ +ID +++L+L
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

11) Snas_5356 in NC_013947


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  378 bits (1420),  Expect = 3e-106, Method: Compositional matrix adjust.
 Identities = 212/342 (62%), Positives = 282/342 (83%), Gaps = 1/342 (0%)

Query  1    MAKSKVGIVFGGACEENPVSVKSAQEVARNLDTDKYEVLYIGITKTGDWLLCDSPDTGWE  60
            M + KV+I+FGG  EE+ VSVKSA E+A N+DT+K++  YIGITK G W LC  P T WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   TTKNRPAVLSPDRNVHGLLVLENGKYETIRLDLVFPVLHGKLGEDGAIQGLLELSGIPYV  120
            +  + PA+LSPDR+ HGLLV+ ++ YET R+D+ FPVLHGK+GEDGAIQGL+ LSGIPYV
Sbjct  61   A-DSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDVQTSALCMDKSLTYLVAQHAGITTPQYWIVTANKDIEPDRLPYPVVVKPARSGSSFG  180
            GCD+Q+SA CMDKSL+Y+++++AGI+ P++ I+      E++ L YPV VKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  VNKVTHEEELQTAIDTARQYDSKVLIEEAIVGTEVGCSILGERYGLVAGEVDQINVSQGI  240
            V KV   EEL++AI++A QYD+K+LIE+AI G EVGC+++G+  +L+ GEVDQI +S+GI
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQENNPESGSENSTITVPADISLESRSLVQETAKTLYRALGGKGLARIDFFLKEDGT  300
            FRIHQEN+PE GSEN+ ITVPADI++E R+ VQETAK +YR LG +GLAR+D+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  LVLNEVQTLPGMTSYSRYPRMMAAAGIPMADLIDRMVSLTLN  342
            +VLNEV+T+PG TSYSRYPRM+AAAGI ++ LID +++L+L+
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

12) BN6_49760 in NC_019673


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  370 bits (1391),  Expect = 7e-104, Method: Compositional matrix adjust.
 Identities = 207/338 (62%), Positives = 277/338 (82%), Gaps = 1/338 (0%)

Query  1    MKIGIIFGGTSEEHPVSVKSAQEVAKSLDPEKYEPYWIGIAENGSWWLCDGPDVDGEGGG  60
            +K++IIFGG SEEH VSVKSA E+A ++D EK++P  IGI+ NG W LC  P  + E+++
Sbjct  4    IKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWEADS  63

Query  61   RRPVVLSTDSGVHGLLVLEDGKYEEVGLDVVLPVLHGRFGEDGAVQGLLEFSGIPYVGCD  120
              P +LS D   HGLLV+ ++ YE   +DV +PVLHG+FGEDGA+QGL+ +SGIPYVGCD
Sbjct  64   L-PAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCD  122

Query  121  VQSSALCMDKALAYTVVRAAGIPTPDFLVVPAGEDVEPGGLTYPVFVKPARSGSSFGVTK  180
            +QSSA CMDK+LAY + + AGI+ P+F ++  G+  E+G+LTYPVFVKPARSGSSFGVTK
Sbjct  123  IQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTK  182

Query  181  VSRPEELRSAVETARRYDSKVLVEEGIVAAEIGCAILGDDVDLVIGEPDQITLSHGIFRI  240
            V+  EEL +A+E+A +YD+K+L+E++I + E+GCA++G++ DL++GE DQI LSHGIFRI
Sbjct  183  VNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRI  242

Query  241  HQEENPEGGSENSTITVPADIPAESRALVQETGKAVYRALGCRGLARVDLFLTDDGEVIL  300
            HQE++PE GSEN+ ITVPADIP E R  VQET+K VYR LGCRGLARVDLFL +DG ++L
Sbjct  243  HQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVL  302

Query  301  NEVNTLPGLTSYSRYPRMMAAAGLSPADVLDRLVSLAV  338
            NEVNT+PG+TSYSRYPRM+AAAG++ + ++D L++LA+
Sbjct  303  NEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

13) ddlA in NC_022116


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  369 bits (1385),  Expect = 2e-103, Method: Compositional matrix adjust.
 Identities = 222/341 (66%), Positives = 280/341 (83%), Gaps = 3/341 (0%)

Query  1    MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWE  60
            MNR+KV+IIFGG SEEH VSVKSA E+A ++DT K++P  IGITK+G WKL   P   WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   AGR-TVVLSPDRSVPGLLVLEDGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAG  119
            A+    +LSPDR   GLLV+ ++ YET  +DV +PVLHGK+GEDGA+QGL+ LSGIPY G
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  120  CDVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGD--DAGAFTYPVFVKPARsgssfgv  177
            CD+ SSA CMDKSLAY+++ +AGIA P F+ +  GD  +AGA+TYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  178  skvsgREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFF  237
            +KV+G EEL AAI +A+QYD+K+LIE+A+ G EVGCAV+GN  +L+ GEVD+I LSHG+F
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  238  RIHQEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTV  297
            RIHQE++PE GSEN+   VPAD+P E R RVQ+TAK +YR LGC+GLARVD+FL +DG +
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  298  VLNEVNTLPGLTSYSRYPRMMAAAGVPLSALIDRLVSLAMT  338
            VLNEVNT+PG+TSYSRYPRM+AAAG+ L+ALID L++LA+ 
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

14) vanB in NC_017186


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  369 bits (1385),  Expect = 2e-103, Method: Compositional matrix adjust.
 Identities = 222/341 (66%), Positives = 280/341 (83%), Gaps = 3/341 (0%)

Query  1    MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWE  60
            MNR+KV+IIFGG SEEH VSVKSA E+A ++DT K++P  IGITK+G WKL   P   WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   AGR-TVVLSPDRSVPGLLVLEDGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAG  119
            A+    +LSPDR   GLLV+ ++ YET  +DV +PVLHGK+GEDGA+QGL+ LSGIPY G
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  120  CDVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGD--DAGAFTYPVFVKPARsgssfgv  177
            CD+ SSA CMDKSLAY+++ +AGIA P F+ +  GD  +AGA+TYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  178  skvsgREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFF  237
            +KV+G EEL AAI +A+QYD+K+LIE+A+ G EVGCAV+GN  +L+ GEVD+I LSHG+F
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  238  RIHQEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTV  297
            RIHQE++PE GSEN+   VPAD+P E R RVQ+TAK +YR LGC+GLARVD+FL +DG +
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  298  VLNEVNTLPGLTSYSRYPRMMAAAGVPLSALIDRLVSLAMT  338
            VLNEVNT+PG+TSYSRYPRM+AAAG+ L+ALID L++LA+ 
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

15) ddlA in NC_018266


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  369 bits (1385),  Expect = 2e-103, Method: Compositional matrix adjust.
 Identities = 222/341 (66%), Positives = 280/341 (83%), Gaps = 3/341 (0%)

Query  1    MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWE  60
            MNR+KV+IIFGG SEEH VSVKSA E+A ++DT K++P  IGITK+G WKL   P   WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   AGR-TVVLSPDRSVPGLLVLEDGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAG  119
            A+    +LSPDR   GLLV+ ++ YET  +DV +PVLHGK+GEDGA+QGL+ LSGIPY G
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  120  CDVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGD--DAGAFTYPVFVKPARsgssfgv  177
            CD+ SSA CMDKSLAY+++ +AGIA P F+ +  GD  +AGA+TYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  178  skvsgREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFF  237
            +KV+G EEL AAI +A+QYD+K+LIE+A+ G EVGCAV+GN  +L+ GEVD+I LSHG+F
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  238  RIHQEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTV  297
            RIHQE++PE GSEN+   VPAD+P E R RVQ+TAK +YR LGC+GLARVD+FL +DG +
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  298  VLNEVNTLPGLTSYSRYPRMMAAAGVPLSALIDRLVSLAMT  338
            VLNEVNT+PG+TSYSRYPRM+AAAG+ L+ALID L++LA+ 
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

16) ddlA in NC_014318


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  369 bits (1385),  Expect = 2e-103, Method: Compositional matrix adjust.
 Identities = 222/341 (66%), Positives = 280/341 (83%), Gaps = 3/341 (0%)

Query  1    MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWE  60
            MNR+KV+IIFGG SEEH VSVKSA E+A ++DT K++P  IGITK+G WKL   P   WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   AGR-TVVLSPDRSVPGLLVLEDGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAG  119
            A+    +LSPDR   GLLV+ ++ YET  +DV +PVLHGK+GEDGA+QGL+ LSGIPY G
Sbjct  61   ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVG  120

Query  120  CDVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGD--DAGAFTYPVFVKPARsgssfgv  177
            CD+ SSA CMDKSLAY+++ +AGIA P F+ +  GD  +AGA+TYPVFVKPARSGSSFGV
Sbjct  121  CDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFGV  180

Query  178  skvsgREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFF  237
            +KV+G EEL AAI +A+QYD+K+LIE+A+ G EVGCAV+GN  +L+ GEVD+I LSHG+F
Sbjct  181  TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF  240

Query  238  RIHQEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTV  297
            RIHQE++PE GSEN+   VPAD+P E R RVQ+TAK +YR LGC+GLARVD+FL +DG +
Sbjct  241  RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI  300

Query  298  VLNEVNTLPGLTSYSRYPRMMAAAGVPLSALIDRLVSLAMT  338
            VLNEVNT+PG+TSYSRYPRM+AAAG+ L+ALID L++LA+ 
Sbjct  301  VLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

17) vanB in NC_013131


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  364 bits (1368),  Expect = 4e-102, Method: Compositional matrix adjust.
 Identities = 204/341 (60%), Positives = 285/341 (84%), Gaps = 1/341 (0%)

Query  1    MDKLNIGIMFGGCSEEHPISVKSAREVAKNLDTSKYEPFYIGITRDGAWRLCDGPEENWE  60
            M++++++I+FGGCSEEH +SVKSA E+A N+DT K++P YIGIT++G W+LC  P  +WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGASRPAVVSPDRGAHGLLVLDQGRYEAIRLDLVLPVLHGKLGEDGAIQGLLELAGIPYV  120
             + S PA++SPDR +HGLLV+ ++ YE+ R+D+ +PVLHGK+GEDGAIQGL+ L+GIPYV
Sbjct  61   -ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDVQTSVLCIDKTLTYLVIQNEGIATPRFWTLTPDEKIDPNELPYPVFVKPARsgssfg  180
            GCD+Q+S  C+DK+L+Y++ +N GIA P F  +  ++K ++  L YPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  vskvsgkDELSGAIEEARLYDAKVLIEEAVVGSEIGCAVLGTGEDLLVGEVDRVALTHGF  240
            V+KV+G +EL++AIE A  YD+K+LIE+A+ G E+GCAV+G  +DL+VGEVD++ L+HG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FKIHQESAPETGSENATFIVPADIPAQSRALIQETAKLVYRALGCRGLSRVDFFLKEDGT  300
            F+IHQE+ PE GSENA + VPADIP + R  +QETAK VYR LGCRGL+RVD+FL+EDG 
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VVLNEVNTLPGLTSYSRYPRMMAAAGFPMSEVIDRLVAVTI  341
            +VLNEVNT+PG+TSYSRYPRM+AAAG+ ++ +ID L+++++
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

18) ddl in NC_021252


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  360 bits (1353),  Expect = 6e-101, Method: Compositional matrix adjust.
 Identities = 206/341 (61%), Positives = 277/341 (82%), Gaps = 1/341 (0%)

Query  1    MGRLKIGILFGGLSEEHPISIKSAREVQKHLDLEKYEPYYIGITQSGSWMLCDGPAEDWE  60
            M R+K++I+FGG SEEH +S+KSA E+  ++D EK++P YIGIT++G W LC  P  +WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGDVRPAVLSPDRGVHGLLVLDEGKYETIALDVVLPVLHGKFGEDGAMQGLLEISGIPYV  120
             + + PA+LSPDR  HGLLV+ E+ YET  +DV +PVLHGKFGEDGA+QGL+ +SGIPYV
Sbjct  61   ADSL-PAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDLPSSVMCIDKSLTYSVVRGAGIATPTFHIVTPDNDVDPDALNYPVFVKPARsgssfg  180
            GCD+ SS  C+DKSL+Y + + AGIA P F+I+  ++  +++AL YPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  vskvsskeeLPAALAEARQYDAKILIEEAVIGSEIGCSILGDGEDLFAGEVDRVALTHGF  240
            V+KV++ EEL AA+  A QYD+KILIE+A+ G E+GC+++G+ +DL+ GEVD++ L+HG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FKIHQEKSPETGSENSSFIVPADIPDASRDLVQETAKVIYRALGCSGLARVDLFLKEDGS  300
            F+IHQE+ PE GSEN+ + VPADIP   R+ VQETAK +YR LGC GLARVDLFL+EDG+
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VVLNEVNTLPGLTSYSRYPRMMNAAGLSLGDVIDRLVKLTL  341
            +VLNEVNT+PG+TSYSRYPRM+ AAG++L  +ID L+ L+L
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

19) Cwoe_1414 in NC_013739


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  359 bits (1347),  Expect = 2e-100, Method: Compositional matrix adjust.
 Identities = 206/342 (61%), Positives = 276/342 (81%), Gaps = 1/342 (0%)

Query  1    MHRLKTGVIFGGCSEEHPISVKSAQEVARHLDPARYEPFYIGITTSGAWKLCDGPDADWE  60
            M+R+K ++IFGGCSEEH +SVKSA E+A ++D  +++P YIGIT +G WKLC  P ++WE
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  61   NGRCRPATLSPDRSARGLLVLEYGRYETISLDVVLPVLHGKLGEDGAMQGLLELSGIPYA  120
             +   PA LSPDR ++GLLV+  + YET  +DV +PVLHGK+GEDGA+QGL+ LSGIPY 
Sbjct  61   ADS-LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYV  119

Query  121  GCDVQSSALCMDKSLTYTVARAAGIATPRFWTVTANEHVDPDQLPYPVFVKPARsgssfg  180
            GCD+QSSA CMDKSL+Y +++ AGIA P F  +   +  +++ L YPVFVKPARSGSSFG
Sbjct  120  GCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGALTYPVFVKPARSGSSFG  179

Query  181  vskvsgRDELPGALDVARRYDSKVLVEEAVVGSEIGCAILGNGLDLLAGEVDQIALSHGF  240
            V+KV+G +EL +A++ A +YD+K+L+E+A+ G E+GCA++GN  DL+ GEVDQI LSHG+
Sbjct  180  VTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGI  239

Query  241  FRIHQEDEPERGSDNSSVTVPAAISQEARALVQETAKAAYRALGCRGLSRVDMFLTADGD  300
            FRIHQE+EPE+GS+N+ +TVPA I+ E R  VQETAK  YR LGCRGL+RVD+FL  DG+
Sbjct  240  FRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGG  299

Query  301  VVLNEVNTLPGMTSYSRYPRMMAAAGLPFAEVIDRIVALALT  342
            +VLNEVNT+PG TSYSRYPRM+AAAG+ ++ +ID +++LAL 
Sbjct  300  IVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

20) CLS_04660 in NC_021047


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  261 bits (975),  Expect = 6e-71, Method: Compositional matrix adjust.
 Identities = 163/351 (47%), Positives = 243/351 (70%), Gaps = 17/351 (4%)

Query  41   RKKIAVIFGGCSPEYSVSLQSAYAVISHMDTEVYTPVLIGISQSGDWFLYEGDIEKIVSD  100
            R K+A+IFGGCS E  VS++SA  + +++DTE + P  IGI+++G W L      K    
Sbjct  3    RIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKPCT  57

Query  101  TWCGGKDCTPVVVSPNRTSHNLLLLENGKVKKLHIDAAFPVLHGRNGEDGTIQGLFEMAG  160
             W    D  P ++SP+R +H LL++ ++     +ID AFPVLHG+ GEDG+IQGLF ++G
Sbjct  58   EW--EADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  161  IPVVGCGVLSSALCMDKDRAHKLVHTAGIAVPSSFVLGKSASVATALQQAEKIGYPLFVK  220
            IP VGC++ SSA CMDK  A  L   AGIAVP   +++K+        +A  + YP+FVK
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDK-----PEAGALTYPVFVK  170

Query  221  PVKAGSSFGITKVSSSNELPAALELAFEYDKRVIVEECISGFEVGCAILG-DEDLTVGEV  279
            P ++GSSFG+TKV++++EL AA+E A +YD ++++E+ ISG EVGCA++G ++DL VGEV
Sbjct  171  PARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEV  230

Query  280  DEIELSGGFFNFTEKYTLKTSA----IHVPARIPQNTAEQIKQAAKTIYRTLDCQGFARV  335
            D+I LS G+F + +      ++    I VPA IP +  ++++++AK +YR L+C+G+ARV
Sbjct  231  DQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARV  290

Query  336  DLFLTPSGEIVFNEVNTIPGFTTHSRYPNMMKAAGFTFEQIVSALIEQAVR  386
            DLFL   G IV+NEVNT+PGFT+ SRYP M+ AAG+T+  ++ +LI  A++
Sbjct  291  DLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

21) OBV_09510 in NC_016048


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  258 bits (964),  Expect = 4e-70, Method: Compositional matrix adjust.
 Identities = 167/352 (48%), Positives = 238/352 (68%), Gaps = 17/352 (4%)

Query  1    MKRLNIAILFGGCSPEYSVSLQSAYSVIKQIDTYKFMPILIGISSKGNWYRFDGDIEKIA  60
            M+R+++AI+FGGCS E  VS++SA  +  +IDT KF P  IGI+ +G W      + K +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKP  55

Query  61   SDTWCNPSDCLPAVILPDRETHTLLVFHSDKVVKLPIDAAFPVLHGKNGEDGMVQGLFEM  120
               W   +D LPA++ PDR TH LLV          ID AFPVLHGK GEDG +QGLF +
Sbjct  56   CTEW--EADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVL  113

Query  121  AGIPLVGCGTLASALCMDKDRAHKLAHAAGVQIPVSFILKKNMDAGIALERAESLGYPLF  180
            +GIP VGC+  +SA CMDK  A  L+  AG+ +P   I+ K   +      A +L YP+F
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPE-----AGALTYPVF  168

Query  181  VKPVRAGSSYGITKVIDRHDLPAAIKLAFEYDDEVILEESITGFEVGCAVMGNEN-LTVG  239
            VKP R+GSS+G+TKV + ++L AAI  A +YD+ +++E++I+G EVGCAVMGNE+ L VG
Sbjct  169  VKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVG  228

Query  240  EVDEIELSDGFFNFTEKYTLKTSA----IHVPARISEEKAEEIKQTAKTIYQALGCRGFA  295
            EVD+I LS+G+F + +      ++    I VPA I+ E  + +++TAK +Y+ LGCRG+A
Sbjct  229  EVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLA  288

Query  296  RVDMFLNADGRVIFNEINTIPGFTSHSRYPNMMKAVGISFEQVISHVIELAV  347
            RVD+FL+ DG +++NE+NT+PGFTS SRYP M+ A GI++  +I  +I LA+
Sbjct  289  RVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

22) Desgi_1749 in NC_021184


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  253 bits (944),  Expect = 1e-68, Method: Compositional matrix adjust.
 Identities = 160/350 (46%), Positives = 235/350 (68%), Gaps = 17/350 (4%)

Query  4    EKNKVAVLFGGCSTEYEVSLQSAYSVITNLNPNKYETILIGITRQGAWLRYYGSLEKIQN  63
            ++ KVA++FGGCS E +VS++SA  + +N++ +K++   IGIT++G W      L K   
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKPC  56

Query  64   DTWMDSNDCVPAIISPDRNIHGLLEFRGNKVIATRIDVAFPVLHGKNGEDGTLQGLLTIA  123
              W    D +PAI+SPDR+ HGLL  + +   + RIDVAFPVLHGK GEDG++QGL+ ++
Sbjct  57   TEW--EADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLS  114

Query  124  GIPFAGCGTLCSAMCMDKDIAHKIANLAGIKTPPSVVLRSGFTDAELMKQISYLTFPLFV  183
            GIP+ GC+   SA CMDK +A  +++ AGI  P   ++  G        + + LT+P+FV
Sbjct  115  GIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKG-----DKPEAGALTYPVFV  169

Query  184  KPANAGSSFGITKVLQKDELSDAVTVAFQHDNKVIIEEAVDGFEVGCAVLGN-DSLAIGE  242
            KPA +GSSFG+TKV   +EL+ A+  A Q D K++IE+A+ G EVGCAV+GN D L +GE
Sbjct  170  KPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGE  229

Query  243  VDEIELSHGFFDYTEKY----TLKTSKIHMPARIDPDTAERIKQTASVIYRALDCSGFAR  298
            VD+I LSHG+F   +          + I +PA I  +  +R+++TA  +YR L+C G+AR
Sbjct  230  VDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLAR  289

Query  299  VDLFLTPEKEIIFNEVNTIPGFTSHSRYPNMLKGIGMTFGQIVDAAISLA  348
            VDLFL  +  I++NEVNT+PGFTS SRYP M+ + G+T+  ++D+ I+LA
Sbjct  290  VDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLA  339

23) Clos_2860 in NC_009922


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  243 bits (906),  Expect = 1e-65, Method: Compositional matrix adjust.
 Identities = 153/354 (44%), Positives = 239/354 (68%), Gaps = 17/354 (4%)

Query  1    MGKIVVAVIFGGESSEYEVSLKSASAVMENLDIEKYDVIKIGITRDGKWLRYNGTLDKIK  60
            M +I VA+IFGG S E +VS+KSA  +  N+D EK+D   IGIT++G W      L K  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKP  55

Query  61   ENTWFLDGSCRQIMLSPNKGDRKIIEIHPNEFVHTQIDIVFPVLHGRNGEDGTLQGLFEI  120
               W  ++     +LSP++  + ++ +  +E+   +ID+ FPVLHG+ GEDG++QGLF +
Sbjct  56   CTEW--EADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVL  113

Query  121  TGIPYVGCDVAASSICIDKDYAHKIVQYAGFDVPQSIAIDNRTKEDEINKFAENVGYPIY  180
            +GIPYVGCD+ +S+ C+DK  A  + + AG+ VP+   ID+  K +     A  + YP++
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPE-----AGALTYPVF  168

Query  181  VKPSREGSSIGITKAENHSDLMGGIEAALKLDGKVVLEENIEGFEVGCAILGN-DDLIVG  239
            VKP+R GSS+G+TK +   +L ++IEAA + DGK+++E+ I G EVGCA++GN DDLIVG
Sbjct  169  VKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVG  228

Query  240  TVDEIEVPNGFFDFTEKY----TLQNSKIHLPARIDQDLSERIKEIGKGIYKALGCSGLS  295
             VD+I +++G+F + +        +N+ I +PA I  +  +R++E +K +Y+ LGC GL+
Sbjct  229  EVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLA  288

Query  296  RVDLFVDKNHRIVFNEVNTLPGFTTGSRFPNMLLHAGIAYRDILDKLIDLGMQR  349
            RVDLF++ +  IV+NEVNT+PGFT+ SR+P M+  AGI+   ++D LI L+++R
Sbjct  289  RVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

24) Clo1100_2030 in NC_016791


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  243 bits (906),  Expect = 2e-65, Method: Compositional matrix adjust.
 Identities = 155/354 (44%), Positives = 236/354 (67%), Gaps = 17/354 (4%)

Query  1    MDRKNIAIIFGGCSPEYEVSLNSVSSVIEHVNNDLYNTILIGITKEGEWLRYFGDVDKIR  60
            M+R ++AIIFGGCS E +VS++S   +  +++ + ++   IGITK+G W      + K  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKP  55

Query  61   NNTWFQEKGCNPVAFSQSRSIHGFYEFSEGSSSITFVDAAFPILHGRNGEDGTVQGMLKL  120
               W  E +  P  +S  R  HG+    E+      +D AFP+LHG+ GEDG++QG++ L
Sbjct  56   CTEW--EADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVL  113

Query  121  AGIPFVGCGILSSAMCMDKDIAHRIAQSSGIRVPISISADKNMILKDILIMAETLRYPVF  180
            +GIP+VGC+I SSA CMDK +A  +++++GI VP     + ++I K+    A +L YPVF
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVP-----EFQIIDKGDKPEAGALTYPVF  168

Query  181  VKPARAGSSFGITRANSRSELEKAIINAFEYDSKIVVEENIDGFEVGCAILGN-DDLIIG  239
            VKPAR+GSSFG+T+ N+  EL+ AI  A +YD+KI++E+ I G EVGCA++GN DDLI+G
Sbjct  169  VKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVG  228

Query  240  EVDEIELQTGFFDYNEKY----TLKTSKIHMPARIDKVTSERVKNTARILYNALYCTGFA  295
            EVD+I L  G+F  ++          + I +PA I     +RV++TA+ +Y  L C G+A
Sbjct  229  EVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLA  288

Query  296  RVDMFLTPKGEIVFNEVNTIPGFTAHSRYPNMLRGAGLSFASIVDRLIRMAMEK  349
            RVD+FL   G IV+NEVNT+PGFT+ SRYP M+ +AG+++++++D LI +A+ +
Sbjct  289  RVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

25) BBR47_05870 in NC_012491


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  239 bits (890),  Expect = 3e-64, Method: Compositional matrix adjust.
 Identities = 157/352 (45%), Positives = 243/352 (70%), Gaps = 17/352 (4%)

Query  1    MKKLTVAILFGGCSSEYEVSLKSTSSVLESLCLEKYEVILLGITREGQWLRYTGNIESIR  60
            M+++ VAI+FGGCS E +VS+KS+  +  ++  EK++   +GIT++G W     ++    
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKP  55

Query  61   NDSWHQSEKCVPAFLSPCRQVRGIVTQENGAMTVTKVDVVFPILHGKNGEDGTVQGLLEL  120
               W+     +PA+LSP R+ +G++   ++     ++DV FP+LHGK GEDG++QGL+ L
Sbjct  56   CTEWEADS--LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVL  113

Query  121  AGIPFVGCHTLSSAICMDKDIAHTLAEGSGIKTPRSVAVYPNTDLATVQAATEPLGFPLY  180
            +GIP+VGC+  SSA CMDK +A  L+  +GI    +V+ +   D +  ++ + +L +P++
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGI----AVPEFQIIDKGD-KPEAGALTYPVF  168

Query  181  VKPAKAGSSIGITKAYSLSELFFGIENALQHDDKVVIEENITGFEVGCAVLGNRE-VIVG  239
            VKPA++GSS+G+TK  +  EL  +IE A Q D+K++IE+ I+G EVGCAV+GN + +IVG
Sbjct  169  VKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVG  228

Query  240  EVDEIELLQGFFDYTEKY----SLETAHIHVPARIDEELAHKIKQTATHLYQVFGCRGFA  295
            EVD+I L +G+F   +      + E A I VPA I  E  +++++TA  +Y+V+GCRG+A
Sbjct  229  EVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLA  288

Query  296  RVDMFVTPDGDIVFNEVNTIPGFTSKSRYPSMLRAAGISYKELLDTLIMLAL  347
            RVD+F+  DG+IV+NEVNT+PGFTS SRYP M+ AAGI+   L+D+LI LAL
Sbjct  289  RVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

26) RBR_17480 in NC_021013


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  234 bits (872),  Expect = 8e-63, Method: Compositional matrix adjust.
 Identities = 150/351 (43%), Positives = 227/351 (65%), Gaps = 18/351 (5%)

Query  1    MQKKKIAVIFGGNSTEYEVSLQSAFSVFENINHDKYDIIPIGITRNGDWYHYKGRYENIA  60
            M++ K+A+IFGG S E +VS++SA+ +  NI+ +K+D   IGIT+NG W   K    +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NNTWSGDRDNLYPVTVSVSHSQKGIWEFDEDQYTAVHIDLVFPILHGKNGEDGTLQGMFE  120
               W +D     P  +S  +   G+    E +Y + +ID+ FP+LHGK GEDG++QG+F 
Sbjct  59   ---WEADS---LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFV  112

Query  121  LSGIPVIGCNTLASALCMDKDRAHKLVSLAGVKVPKSVTFKRSEKNTALKKIETELSYPL  180
            LSGIP +GC+  +SA CMDK  A  L   AG+ VP    + +++K  A       L+YP+
Sbjct  113  LSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEA-----GALTYPV  167

Query  181  FVKPVRAGSSFGITKVTEQAEINTAIESAFEHDTEVIVEEAIGGFEVGCAILGI-DNLTV  239
            FVKP R+GSSFG+TKV    E+N+AIE+A + D  +++E+AI+G EVGCA++G  D+L V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  RRIDEIELSNGFFDYTEKY----TLKTSKIHMPARLSPKEEKRVQETAVAIYKALGCSGF  295
              +D+I LS+G+F   +          + I +PA ++  E +RVQETA  +Y+ LGC G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDMFYTPSNEIIFNEVNTIPGLTSHSRYPNMMKGIGLSFADMLDKLISL  346
            ARVD+F      I++NEVNT+PG+TS SRYP M+ + G++++ ++D LI+L
Sbjct  288  ARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITL  338

27) vanG in NC_018664


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  232 bits (865),  Expect = 2e-62, Method: Compositional matrix adjust.
 Identities = 161/351 (46%), Positives = 234/351 (67%), Gaps = 17/351 (4%)

Query  2    KKTIAIIFGGCSSEYEVSLqsassiiqaiDRDKYNLFLIGITKDGTWLHYKNELSKIAEN  61
            +  +AIIFGGCS E +VS++SA  I   ID +K++   IGITK+G W      L K +  
Sbjct  3    RIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-----KLCKKPCT  57

Query  62   TWMEDNTCCPVMFSPNRVDHGILLFEKDQIKKVWIDMAFPILHGKNGEDGTIQGLCELAG  121
             W  D+   P ++SP+R  HG+L+    +    +ID+AFP+LHGK GEDG+IQGL  L+G
Sbjct  58   EWEADSL--PAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  122  IPIIGCDTLSSALCMDKDMAHRVVKASGIKVPESYVLQNIIDENIIYTEAKKLGYPLFVK  181
            IP +GCD  SSA CMDK +A  + K +GI VPE  ++++  +++    EA  L YP+FVK
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDK--GDK---PEAGALTYPVFVK  170

Query  182  PVKAGSSFGITKVKNENELIPAILEAFQHDNEVVLEENIYGFEVGCAILGNE-DLTVGEL  240
            P ++GSSFG+TKV+  +EL +AI  A Q D  +++E+ I G EVGCA++GNE DL VGE+
Sbjct  171  PARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEV  230

Query  241  DEIEVEDGFFDYIQKYTL-KASE---IHMPARVEESKSKEIKSIAVKIYRALGCKDFARV  296
            D+I + +G+F   Q     K+SE   I +PA +     + ++  A K+YR LGC+++ARV
Sbjct  231  DQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARV  290

Query  297  DMFITPDGEIVFNEVNTIPGFTSHSRYPNMMKGIGMTFEDVIAHILDLAVK  347
            D+F+  DG IV+NEVNT+PGFTS SRYP M+ + G+T+  +I  ++ LA+K
Sbjct  291  DLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALK  341

28) vanG in NC_009089


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  224 bits (835),  Expect = 7e-60, Method: Compositional matrix adjust.
 Identities = 156/371 (43%), Positives = 234/371 (64%), Gaps = 35/371 (9%)

Query  1    MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDILPIGITREGNWYHYIGDYNNIQ  60
            MN  K+A+IFGG S E DVS++SA+ +  N++TEK+D   IGIT++G W        +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NNTWFERDTDIIPVIVSQNRVKNGIIEFLISDAVSQNHIPNSAIESCENDIKYTKLDFVF  120
               W   ++D +P I+S +R  +G   +L+                 E++    ++D  F
Sbjct  59   ---W---EADSLPAILSPDRKTHG---LLVMK---------------ESEYETRRIDVAF  94

Query  121  PVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDKSHKLVHSEGIKVPKSILLKY  180
            PVLHGK GEDG++QGLF L+GI  +GC+  SSA CMDK  +  L  + GI VP   ++  
Sbjct  95   PVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDK  154

Query  181  SDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID  240
            +DK + + L    TYP+F+KP R+GSSFG++K+   EEL+ A++ A + D  ++IE+ I 
Sbjct  155  GDKPEAGAL----TYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAIS  210

Query  241  GFEVGCAVLGN-NDLLVGRVDEIELSKGFFDYTEKY----TLKSSKIHMPARIDLDCEKR  295
            G EVGCAV+GN +DL+VG VD+I LS G+F   +         ++ I +PA I ++  +R
Sbjct  211  GCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNR  270

Query  296  IQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEE  355
            +QETAK +YR LGC G+ARVD+FL   G I++NEVNT+PGFTS SRYP M+ + G+++  
Sbjct  271  VQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPA  330

Query  356  ILDKIIEVYIK  366
            ++D +I + +K
Sbjct  331  LIDSLITLALK  341

29) CDBI1_08005 in NC_017179


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  224 bits (835),  Expect = 7e-60, Method: Compositional matrix adjust.
 Identities = 156/371 (43%), Positives = 233/371 (63%), Gaps = 35/371 (9%)

Query  1    MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGITREGNWYHYIGDYNNIQ  60
            MN  K+A+IFGG S E DVS++SA+ +  N++TEK+D   IGIT++G W        +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNSAIESCENDIKYTKLDFVF  120
               W   ++D +P I+S +R  +G++                     E++    ++D  F
Sbjct  59   ---W---EADSLPAILSPDRKTHGLLVMK------------------ESEYETRRIDVAF  94

Query  121  PVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDKSHKLVHSEGIKVPKSILLKY  180
            PVLHGK GEDG++QGLF L+GI  +GC+  SSA CMDK  +  L  + GI VP   ++  
Sbjct  95   PVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDK  154

Query  181  SDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID  240
            +DK + +     LTYP+F+KP R+GSSFG++K+   EEL+ A++ A + D  ++IE+ I 
Sbjct  155  GDKPEAG----ALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAIS  210

Query  241  GFEVGCAVLGN-DDLLVGRVDEIELSKGFFDYTEKY----TLKSSKIHMPARIDLDCEKR  295
            G EVGCAV+GN DDL+VG VD+I LS G+F   +         ++ I +PA I ++  +R
Sbjct  211  GCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNR  270

Query  296  IQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEE  355
            +QETAK +YR LGC G+ARVD+FL   G I++NEVNT+PGFTS SRYP M+ + G+++  
Sbjct  271  VQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPA  330

Query  356  ILDKIIEVYIK  366
            ++D +I + +K
Sbjct  331  LIDSLITLALK  341

30) vanG in NC_013315


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  224 bits (835),  Expect = 7e-60, Method: Compositional matrix adjust.
 Identities = 156/371 (43%), Positives = 233/371 (63%), Gaps = 35/371 (9%)

Query  1    MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGITREGNWYHYIGDYNNIQ  60
            MN  K+A+IFGG S E DVS++SA+ +  N++TEK+D   IGIT++G W        +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNSAIESCENDIKYTKLDFVF  120
               W   ++D +P I+S +R  +G++                     E++    ++D  F
Sbjct  59   ---W---EADSLPAILSPDRKTHGLLVMK------------------ESEYETRRIDVAF  94

Query  121  PVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDKSHKLVHSEGIKVPKSILLKY  180
            PVLHGK GEDG++QGLF L+GI  +GC+  SSA CMDK  +  L  + GI VP   ++  
Sbjct  95   PVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDK  154

Query  181  SDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID  240
            +DK + +     LTYP+F+KP R+GSSFG++K+   EEL+ A++ A + D  ++IE+ I 
Sbjct  155  GDKPEAG----ALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAIS  210

Query  241  GFEVGCAVLGN-DDLLVGRVDEIELSKGFFDYTEKY----TLKSSKIHMPARIDLDCEKR  295
            G EVGCAV+GN DDL+VG VD+I LS G+F   +         ++ I +PA I ++  +R
Sbjct  211  GCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNR  270

Query  296  IQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEE  355
            +QETAK +YR LGC G+ARVD+FL   G I++NEVNT+PGFTS SRYP M+ + G+++  
Sbjct  271  VQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPA  330

Query  356  ILDKIIEVYIK  366
            ++D +I + +K
Sbjct  331  LIDSLITLALK  341

31) vanG in NC_013316


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  224 bits (835),  Expect = 7e-60, Method: Compositional matrix adjust.
 Identities = 156/371 (43%), Positives = 233/371 (63%), Gaps = 35/371 (9%)

Query  1    MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGITREGNWYHYIGDYNNIQ  60
            MN  K+A+IFGG S E DVS++SA+ +  N++TEK+D   IGIT++G W        +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNSAIESCENDIKYTKLDFVF  120
               W   ++D +P I+S +R  +G++                     E++    ++D  F
Sbjct  59   ---W---EADSLPAILSPDRKTHGLLVMK------------------ESEYETRRIDVAF  94

Query  121  PVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDKSHKLVHSEGIKVPKSILLKY  180
            PVLHGK GEDG++QGLF L+GI  +GC+  SSA CMDK  +  L  + GI VP   ++  
Sbjct  95   PVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDK  154

Query  181  SDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID  240
            +DK + +     LTYP+F+KP R+GSSFG++K+   EEL+ A++ A + D  ++IE+ I 
Sbjct  155  GDKPEAG----ALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAIS  210

Query  241  GFEVGCAVLGN-DDLLVGRVDEIELSKGFFDYTEKY----TLKSSKIHMPARIDLDCEKR  295
            G EVGCAV+GN DDL+VG VD+I LS G+F   +         ++ I +PA I ++  +R
Sbjct  211  GCEVGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNR  270

Query  296  IQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEE  355
            +QETAK +YR LGC G+ARVD+FL   G I++NEVNT+PGFTS SRYP M+ + G+++  
Sbjct  271  VQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPA  330

Query  356  ILDKIIEVYIK  366
            ++D +I + +K
Sbjct  331  LIDSLITLALK  341

32) Clole_1511 in NC_015275


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  224 bits (834),  Expect = 8e-60, Method: Compositional matrix adjust.
 Identities = 150/354 (43%), Positives = 231/354 (66%), Gaps = 21/354 (5%)

Query  1    MKKKNVLVIFGGMSNEYEVSLKSAAAAIENMDLSKYNLMMLGITQEGKWLRFFGDVEMIR  60
            M++ +V +IFGG S+E +VS+KSA     N+D  K++   +GIT++G W        + +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-------KLCK  53

Query  61   NH--TWLTDKSCVEAFISPSREQKGLIELSPEGYKVTEVDVVFPILHGKFGEDGTIQGLL  118
            +    W +D   + A++SP R   GL+ +    Y    +DV FP+LHGKFGEDG+IQGL+
Sbjct  54   KPCTEWEADS--LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLF  111

Query  119  ELSGIPFVGCRTLASAICMDKAITHRLVAKEGIKVARSIVLYKEDRNAEQRLEEVDIKLP  178
             LSGIP+VGC   +SA CMDK+++  L  + GI V+   ++ K D+      E   +  P
Sbjct  112  VLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKP-----EAGALTYP  166

Query  179  VYIKPAKSGSSIGITKVFHFEQLEDAISKAFLEDDKVVIEENINGFEVGCAILGNENPMI  238
            V++KPA+SGSS+G+TKV   E+L+ AI  A   D+K++IE+ I+G EVGCA++GNE+ +I
Sbjct  167  VFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLI  226

Query  239  -GEVDEIELMGDFFDFNEKYML----ANSKIHMPARVEKEVAHQIKKTAIKIYEILSCTG  293
             GEVD+I L  ++F +++         N+ I +PA +  E  ++++ TA K+Y +L+C G
Sbjct  227  VGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRG  286

Query  294  LARVDMFLTQGNEIYFNEVNTLPGFTSSSRYPKMMSSIGLSYTDVITRLIELAL  347
            LARVD+FL ++  I +NEVNT+PGFTS SRYP+M+++ G++   +I  LI LAL
Sbjct  287  LARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

33) Ethha_0761 in NC_014828


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  223 bits (831),  Expect = 1e-59, Method: Compositional matrix adjust.
 Identities = 143/357 (41%), Positives = 238/357 (67%), Gaps = 22/357 (6%)

Query  1    MKKPRVAVLFGGMSSEHAVSLVSATSVIANIPRDRFDVVMIGITRDGEWRLFEGDVEKLA  60
            M++ +VA++FGG S EH VS+ SA  + ANI  ++FD   IGIT++G W+L      K +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKP  55

Query  61   GSGWESDPSNRPAFIAPDSRVHGIVALSPDGRIETIRLDVVFPVLHGLNGEDGTVQGLLT  120
             + WE+D+   PA+++PD + HG++ +  ++  ET R+DV FPVLHG  GEDG++QGL+ 
Sbjct  56   CTEWEADSL--PAILSPDRKTHGLLVMK-ESEYETRRIDVAFPVLHGKFGEDGAIQGLFV  112

Query  121  LARIPFVGCGVTASAVCMDKAITKALCDTYQIPQAKWETVRVSDLKDNGKAVVERLEAHL  180
            L+ IP+VGC++ +SA CMDK+++  L     I+ +  + +  +D  + G          L
Sbjct  113  LSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEAGA---------L  163

Query  181  GYPLFVKPANAGSSVGISKAADRETLYKAIETAATHDRKLVFEEAVNGREIECAVLGNEE  240
             YP+FVKPA +GSS G++K  + E L  AIE+A+  D K+++E+A++G E+ CAV+GNE+
Sbjct  164  TYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNED  223

Query  241  P-VVSCCGEIKPCNEFYDYNAKYLAGRTE----LVIPASLPKDVSERVRQTAMRVFRLLG  295
              +V+  ++I+  + ++  +    + +      + +PA +P +  +RV++TA +V+R+LG
Sbjct  224  DLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLG  283

Query  296  CRGLTRMDFFALEDGTVLLNEPNTIPGFTSISMYPKLFEAGGISYGELLETLLRLAM  352
            CRGL+R+D+F  EDG ++LNE NT+PGFTS S YP++  A+GI+   L+++L+ LA+
Sbjct  284  CRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

34) ddl in NC_012034


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  222 bits (828),  Expect = 2e-59, Method: Compositional matrix adjust.
 Identities = 152/356 (43%), Positives = 239/356 (68%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEVIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTQFSIECFVSPDRTKKALVKVKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSGI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LSGI
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVTEEIKDLAGRIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSGIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFTS S YP+++  +GI  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

35) Calhy_0717 in NC_014652


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  222 bits (826),  Expect = 4e-59, Method: Compositional matrix adjust.
 Identities = 152/356 (43%), Positives = 238/356 (67%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTQFSIECFVSPDRTKKALVKIKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSNI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LS I
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLALAIHEAFLYDTKILIEQAINAREIECAVLGN-DDVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN DD++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVIEEIKDLAARIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSGIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFTS S YP+++  +GI  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

36) Calkro_0619 in NC_014720


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  221 bits (824),  Expect = 4e-59, Method: Compositional matrix adjust.
 Identities = 150/356 (43%), Positives = 239/356 (68%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTQFSIECFISPDRTKKALVKIKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSGI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LSGI
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVTEEIKDLAARIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEINTIPGFTSISMYPKLMEFSSIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NE+NT+PGFTS S YP+++  ++I  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

37) Csac_1372 in NC_009437


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  221 bits (824),  Expect = 5e-59, Method: Compositional matrix adjust.
 Identities = 150/356 (43%), Positives = 236/356 (67%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEVSIVSAKSVMQNLDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH+VS+ SA  +  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTMYSIECFISPDRTKKALVKIKDSEATFIDIDVVFPVLHGLNGEDGTVQGLLELSGI  120
              W   S+  ++SPDR   +L+ +K+SE     IDV FPVLHG  GEDG++QGL+ LSGI
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSALCMDKAFAKKLALLEGIPQGHFLVIYKDEYLSKKEYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F +I K++         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDKDELILAIHEAFLYDTKILIEQAINAREIECAVLGN-SEILV  239
            FVKPA SGSS G++K ++ +EL  AI+ A  YD KILIEQAI++ E+ CAV+GN  +++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SALGEIVPSREFYS-YEAKYIDGSSE---LIIPAKLEKQVEDEIKELAVKIYKLFECSGM  295
            + +++I  S+ ++   + +  + +SE   + +PA +  +  + ++E A K+Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARIDFFVDKETNKVYFNEVNTIPGFTSISMYPKLMEYSGIPYPQLLDKLIQLAIEK  351
            AR+D+F++ +   V +NEVNT+PGFTS S YP+++  +GI  P L+D LI LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

38) COB47_1809 in NC_014392


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  221 bits (823),  Expect = 6e-59, Method: Compositional matrix adjust.
 Identities = 149/356 (42%), Positives = 236/356 (67%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTQFSIECFVSPDRTKKALVKIKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSNI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LS I
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKVLIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD K+LIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYSY----EAKYIDDSSELIIPARLPKEVTEEIKDLAARIYKIFECCGM  295
            +E ++I  S+ ++      E+    +++ + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSGIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFTS S YP+++  +GI  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

39) Calow_1724 in NC_014657


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  220 bits (819),  Expect = 1e-58, Method: Compositional matrix adjust.
 Identities = 150/356 (43%), Positives = 240/356 (68%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISLVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   SKWTQFSIECFISPDRTKKALVKIKDNEATFIDIDVIFPVLHGLNGEDGTVQGLLELSDI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LS+I
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVTEEIKDLAVRIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTNISMYPKLMEFSGISYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFT+ S YP+++  +GI+ + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

40) Calkr_0526 in NC_014721


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  219 bits (817),  Expect = 2e-58, Method: Compositional matrix adjust.
 Identities = 150/356 (43%), Positives = 238/356 (67%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NKWTQFSIECFISPDRTKKALVKIKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSNI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LS I
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVVEEIKDLAARIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSSIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFTS S YP+++  ++I  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

41) Calla_1828 in NC_015949


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  219 bits (817),  Expect = 2e-58, Method: Compositional matrix adjust.
 Identities = 150/356 (43%), Positives = 238/356 (67%), Gaps = 19/356 (5%)

Query  1    MTKLKVAVLFGGVSTEHEISIVSAKSIMQNMDKEKYEIIPIGITKEGKWLLYTGKIEDLD  60
            M ++KVA++FGG S EH++S+ SA  I  N+D EK++   IGITK+G W L      +  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE--  58

Query  61   NKWTQFSIECFISPDRTKKALVKIKDNEATFIDIDVVFPVLHGLNGEDGTVQGLLELSNI  120
              W   S+  ++SPDR   +L+ +K++E     IDV FPVLHG  GEDG++QGL+ LS I
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  121  PYVGCGVLSSAICMDKAFAKKLALLEGIPQGHFLVVYKNEYSAKKDYFIRRIESEFSYPV  180
            PYVGC++ SSA CMDK++A  L+   GI+  +F ++ K +         +   + ++YPV
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD---------KPEAGALTYPV  167

Query  181  FVKPANSGSSVGISKAKDREDLVLAIHEAFLYDTKILIEQAINAREIECAVLGN-DEVFV  239
            FVKPA SGSS G++K ++ E+L  AI+ A  YD KILIEQAI++ E+ CAV+GN D+++V
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIV  227

Query  240  SEPGEIIPSREFYS-YEAKYIDNSSE---LIIPARLPKEVVEEIKDLAARIYKIFECCGM  295
            +E ++I  S+ ++   + +  +++SE   + +PA +P E  + +++ A ++Y+++ C G+
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  ARVDFFVDKDTNKVYFNEVNTIPGFTSISMYPKLMEFSSIPYSQLIDKLISLAIEK  351
            ARVD+F++ D   V +NEVNT+PGFTS S YP+++  ++I  + LID LI+LA+ +
Sbjct  288  ARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

42) Tthe_0219 in NC_014410


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  213 bits (792),  Expect = 2e-56, Method: Compositional matrix adjust.
 Identities = 147/358 (42%), Positives = 226/358 (64%), Gaps = 25/358 (6%)

Query  1    MEKLKVAVLFGGQSGEHEVSRVSATSIINNIDRDKYDVYMVGITKKGEWYLYNGDIEKIA  60
            M+++KVA++FGG S EH+VS  SA  I  NID +K+D   +GITK+G W L      K +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKP  55

Query  61   TGEWEKDAVPALIGPSTKYKGILAFKDSRYEFYPIDVVFPVLHGPNGEDGTVQGLLELLE  120
              EWE D++PA+++P  K  G+L  K+S YE   IDV FPVLHG  GEDG++QGL+ L  
Sbjct  56   CTEWEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  121  MPYVGPNVLSSSLCMDKVFSKRIFLEAGIPTPKFTVVYRKELNNVDNYEEIRRRVSEIGY  180
            +PYVG ++ SS+ CMDK ++  +  +AGI+ P F ++ + +          +   + + Y
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD----------KPEAGALTY  165

Query  181  PCFVKPANMGSSVGITKVHNENELMDGLKLASKYDRKIIIEEGIDAREIECSVLGNDNPE  240
            P FVKPA  GSS G+TKV+  +EL  ++  A++YD KI+IE++I + E+ C+V+GN+  +
Sbjct  166  PVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNE--D  223

Query  241  ASIAGEIVP---AHEFY----DYDAKYFDEASKLFIPAPIPDVKMEEIRELAIKAYIALD  293
              I GE+     +H ++    + ++    E + + +PA IP    + ++E A K Y  L+
Sbjct  224  DLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLG  283

Query  294  VRGMARVDFLMDKNTGKVYLNELNTIPGFTKISMYPKLWEASGKPYSKLIDDLIQLAL  351
             RG+ARVD++++ + G V LNE+NT+PGFT  S YP++  A+G   + LID LI LAL
Sbjct  284  CRGLARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

43) Thethe_00207 in NC_019970


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  213 bits (791),  Expect = 2e-56, Method: Compositional matrix adjust.
 Identities = 147/358 (42%), Positives = 226/358 (64%), Gaps = 25/358 (6%)

Query  1    MEKLKVAVLFGGQSGEHEVSRVSATSIINNIDRDKYDVYMVGITKKGEWYLYNGDIEKIA  60
            M+++KVA++FGG S EH+VS  SA  I  NID +K+D   +GITK+G W L      K +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKP  55

Query  61   TGEWEKDAVPALIGPSTKYKGILAFKDSRYEFYPIDVVFPVLHGPNGEDGTVQGLLELLE  120
              EWE D++PA+++P  K  G+L  K+S YE   IDV FPVLHG  GEDG++QGL+ L  
Sbjct  56   CTEWEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  121  MPYVGPNVLSSSLCMDKVFSKRIFLEAGIPTPKFTVVYRKELNNVDNYEEIRRRVSEIGY  180
            +PYVG ++ SS+ CMDK ++  +  +AGI+ P F ++ + +          +   + + Y
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD----------KPEAGALTY  165

Query  181  PCFVKPANMGSSVGITKVHNENELMDGLKLASKYDRKIIIEEGIDAREIECSVLGNDNPE  240
            P FVKPA  GSS G+TKV+  +EL  ++  A++YD KI+IE++I + E+ C+V+GN+  +
Sbjct  166  PVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNE--D  223

Query  241  ASIAGEIVP---AHEFY----DYDAKYFDEASKLFIPAPIPDVKMEEIRELAIKAYVALD  293
              I GE+     +H ++    + ++    E + + +PA IP    + ++E A K Y  L+
Sbjct  224  DLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLG  283

Query  294  VRGMARVDFLMDKNTGKVYLNELNTIPGFTKISMYPKLWEASGKPYSKLIDELIQLAL  351
             RG+ARVD++++ + G V LNE+NT+PGFT  S YP++  A+G   + LID LI LAL
Sbjct  284  CRGLARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

44) Tsac_0772 in NC_017992


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  211 bits (786),  Expect = 5e-56, Method: Compositional matrix adjust.
 Identities = 143/357 (41%), Positives = 225/357 (64%), Gaps = 22/357 (6%)

Query  1    MDKLKVAVLFGGQSGEHEVSRVSATSIINNIDREKYEVYMVGITKNGQWYLYSGDVHKIA  60
            M+++KVA++FGG S EH+VS  SA  I  NID EK++   +GITKNG W L      K +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKP  55

Query  61   TGEWEKEAVPALIGPSTKYKGIIAFKDGSYEFYPIDVVFPVLHGPNGEDGTVQGLLELLE  120
              EWE +++PA+++P  K  G++  K++ YE   IDV FPVLHG  GEDG++QGL+ L  
Sbjct  56   CTEWEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  121  MPYVGPNVLSSSLCMDKVFSKRIFLESGIPTPKFTVVYRKDVNDAEKYEYIKSEILEKIG  180
            +PYVG ++ SS+ CMDK ++  +  ++GI+ P F ++ + D  +A             + 
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEA-----------GALT  164

Query  181  YPCFVKPANMGSSVGITKVHNEGELFDALKIAAKYDRKIIVEEGIDAREIECSVLGNDNP  240
            YP FVKPA  GSS G+TKV+   EL  A+  A++YD KI++E++I + E+ C+V+GN++ 
Sbjct  165  YPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDD  224

Query  241  -EASVAGEIVPAHEFY----DYDAKYFDEASKLFIPAPIPDAKMEEIRDLAIKAYTALDV  295
               +  ++I  +H ++    + ++    E + + +PA IP    + +++ A K Y  L+ 
Sbjct  225  LIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGC  284

Query  296  RGMARVDFLMDKNTGKVYLNELNTIPGFTQISMYPKLWEASGKPYSKLIDELIQLAL  352
            RG+ARVD++++ + G V LNE+NT+PGFT  S YP++  A+G   + LID LI LAL
Sbjct  285  RGLARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

45) Tmath_2122 in NC_014209


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  207 bits (771),  Expect = 7e-55, Method: Compositional matrix adjust.
 Identities = 142/353 (41%), Positives = 228/353 (65%), Gaps = 17/353 (4%)

Query  1    MVKKRIAVLFGGQSGEHEVSLMSAKSIINNLDKDKYEIYMVGITKKGEWYLYRGDVEKIE  60
            M + ++A++FGG S EH+VS+ SA  I  N+D +K++   +GITK+G W L      K  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKP  55

Query  61   TGEWEKEGIPATMGASTKYRGIITFEEGKNVFFPIDVVFPVLHGPNGEDGTIQGLLELLD  120
              EWE +++PA +++  K +G++   E+      IDV FPVLHG  GEDG+IQGL+ L +
Sbjct  56   CTEWEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSG  115

Query  121  IPYVGANVLSSALCMDKVFTKRIFKEAGLPTPDFVVVYRKEIGDLETIKKKIEHLGYPCF  180
            IPYVG ++ SSA CMDK ++  + K+AG++ P+F ++ + +       K     L YP F
Sbjct  116  IPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD-------KPEAGALTYPVF  168

Query  181  VKPANLGSSVGITKVHNEEELPGALKLAAKYDRKLLIEKGIEAREIECSVLGNENP-EAS  239
            VKPA  GSS G+TKV+  EEL +A+  A++YD K+LIE++I + E+ C+V+GNE+    +
Sbjct  169  VKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVG  228

Query  240  VAGEIVPSNEFYDYNAKY---FDGGKSLLLIPAPLPDEKMEEIRKLAIKAYRALDLRGMA  296
              ++I  S+ ++  +       ++ ++++ +PA +P E  + ++  A K YR L+ RG+A
Sbjct  229  EVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLA  288

Query  297  RVDFLMDRNTGTVYLNEVNTIPGFTKISMYPKLWEASGKSYSALLDDLINLAI  349
            RVD++++ + G V LNEVNT+PGFT  S YP++  A+G + +AL+D LI LA+
Sbjct  289  RVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLAL  340

46) ddl in NC_009012


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  205 bits (763),  Expect = 3e-54, Method: Compositional matrix adjust.
 Identities = 150/370 (41%), Positives = 231/370 (63%), Gaps = 35/370 (9%)

Query  3    DKKRVLVIFGGQSSEHEVSRISATSILKNINLDKFDVSMIGITKDGKWLYYDGPIDKIPS  62
            ++ +V +IFGG S EH+VS  SA  I  NI+ +KFD   IGITK+G W        K P 
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKPC  56

Query  63   GEWEEIALKDGTRSIADRVSLFDNIISCKNNACGLEKASENE-KSKKIDVVFPVLHGCNG  121
             EWE  +L                I+S   ++ GL    E+E  +++IDV FPVLHG  G
Sbjct  57   TEWEADSLP--------------AILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFG  102

Query  122  EDGTIQGLFELAGIPYVGCGVLASAVGMDKIYAKIIFEKAGIPQADYLYFTRKEIYGDVE  181
            EDG+IQGLF L+GIPYVGC++ +SA  MDK  A I+  +AGI+ +++  + + +      
Sbjct  103  EDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD------  156

Query  182  GVVDKIEEKFSYPVFVKPSNAGSSVGVSKAHDKNELKEALIYAARYDRKVLIEEFINGRE  241
                     ++YPVFVKP+ +GSS GV+K ++ +EL+ A+  A++YD K+LIE+ I+G E
Sbjct  157  ---KPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCE  213

Query  242  VECAVLGNDDP-VASTVGEIIPGNEFY----DYKAKYIENTSKIKIPADLPEETVEQIRN  296
            V CAV+GN+D  + + V++I  ++ ++    +  +    + + I +PAD+P E  +++++
Sbjct  214  VGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQE  273

Query  297  YAVKAFKALDCSGLARVDFFVHKETGKVYINEINTMPGFTSISMYPMLWEESGISYPELI  356
             A K ++ L+C GLARVD+F++ + G V +NE+NTMPGFTS S YP +   +GI+ P LI
Sbjct  274  TAKKVYRVLGCRGLARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALI  332

Query  357  EKLIDLAVQR  366
            + LI LA++R
Sbjct  333  DSLITLALKR  342

47) Clo1313_2609 in NC_017304


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  205 bits (763),  Expect = 4e-54, Method: Compositional matrix adjust.
 Identities = 150/370 (41%), Positives = 231/370 (63%), Gaps = 35/370 (9%)

Query  3    DKKRVLVIFGGQSSEHEVSRISATSILKNINLDKFDVSMIGITKDGKWLYYDGPIDKIPS  62
            ++ +V +IFGG S EH+VS  SA  I  NI+ +KFD   IGITK+G W        K P 
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLC-----KKPC  56

Query  63   GEWEEIALKDGTRSIADRVSLFDNIISCKNNACGLEKASENE-KSKKIDVVFPVLHGCNG  121
             EWE  +L                I+S   ++ GL    E+E  +++IDV FPVLHG  G
Sbjct  57   TEWEADSLP--------------AILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFG  102

Query  122  EDGTIQGLFELAGIPYVGCGVLASAVGMDKIYAKIIFEKAGIPQADYLYFTRKEIYGDVE  181
            EDG+IQGLF L+GIPYVGC++ +SA  MDK  A I+  +AGI+ +++  + + +      
Sbjct  103  EDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD------  156

Query  182  GVVDKIEEKFSYPVFVKPSNAGSSVGVSKAHDKNELKEALIYAARYDRKVLIEEFINGRE  241
                     ++YPVFVKP+ +GSS GV+K ++ +EL+ A+  A++YD K+LIE+ I+G E
Sbjct  157  ---KPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCE  213

Query  242  VECAVLGNDDP-VASTVGEIIPGNEFY----DYKAKYIDNTSKIKIPADLPEETVEQIRN  296
            V CAV+GN+D  + + V++I  ++ ++    +  +    + + I +PAD+P E  +++++
Sbjct  214  VGCAVMGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQE  273

Query  297  YAVKAFKALDCSGLARVDFFVHKETGKVYINEINTMPGFTSISMYPMLWEESGISYPELI  356
             A K ++ L+C GLARVD+F++ + G V +NE+NTMPGFTS S YP +   +GI+ P LI
Sbjct  274  TAKKVYRVLGCRGLARVDLFLQEDGGIV-LNEVNTMPGFTSYSRYPRMVAAAGITLPALI  332

Query  357  EKLIDLAVQR  366
            + LI LA++R
Sbjct  333  DSLITLALKR  342

48) PALO_04270 in NC_021064


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  201 bits (747),  Expect = 6e-53, Method: Compositional matrix adjust.
 Identities = 148/367 (41%), Positives = 228/367 (63%), Gaps = 32/367 (8%)

Query  1    MNRTHVAVIFGGMSSEHSISCLSAANVVAAIDRERFDVSGVGITPDGVWVRYGVDEILGL  60
            MNR  VA+IFGG S EH +S  SA ++ A ID E+FD   +GIT +GVW       +   
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW------KLCKK  54

Query  61   PST----GQLPVVEVGDRSLVSVKQMPEGTCIVDTEGNADLVQVVFPVLHGPFGEDGTIQ  116
            P T    + LP +   DR   ++  M E      +E ++  ++V FPVLHG FGEDG+IQ
Sbjct  55   PCTEWEADSLPAILSPDRKTHGLLVMKE------SEYETRRIDVAFPVLHGKFGEDGAIQ  108

Query  117  GLLEMAGVRYVGCGVAASANCMDKHLTKMILAEAGVLVGPYVVVRDHEWREDRNAVLKAA  176
            GL+ ++G+ YVGC++ +SA CMDK L+ ++  +AG+ V  + ++   +  E        A
Sbjct  109  GLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPE--------A  160

Query  177  SRLEYPLFVKPARGGSSIGISKVMSPDRLEAAVEVAREHDNKVLIEQGIRGREIECSVLD  236
            + L YP+FVKPAR+GSS+G++KV + + L+AA+E A + D K+LIEQ+I G E+ C+V++
Sbjct  161  GALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMG  220

Query  237  GHHGAAPRASVPGEI-VVHDPDGFYDFEAKYLS--GEQKASVQARAKLDDEIRNRVQKVA  293
             +++      + GE+  ++ ++G++ ++    +  G ++A +   A +  E RNRVQ  A
Sbjct  221  NEDDL-----IVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETA  275

Query  294  IKAFRVLGCEGLARIDTFVAPDGTVYVNEPNTMPGFTRSSGFPLMWQASGMTYAQIVSEL  353
             K +RVLGC GLAR+D F+  DG + +NE NTMPGFT  S +P M  A+G+T + ++  L
Sbjct  276  KKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSL  335

Query  354  IELALER  360
            I LAL R
Sbjct  336  ITLALKR  342

49) ddl in NC_005773


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  197 bits (732),  Expect = 9e-52, Method: Compositional matrix adjust.
 Identities = 144/355 (41%), Positives = 232/355 (66%), Gaps = 21/355 (5%)

Query  2    KKSVAIVFGGQSSEHEVSLQSARNVINAIDRERYTLTLIGVDKLGRWLRFDEADYLLNAN  61
            +  VAI+FGG S EH+VS++SA ++   ID E++    IG+ K G W ++          
Sbjct  3    RIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-KLCKKPCTEWEA  61

Query  62   DPARIKLSASGKQLSLLPGSTGGQFVEVETGKPLAAIDVVFPLIHGAFGEDGALQGVLRM  121
            D+    LS+  K  +LL     +++   ET +    IDV FP++HG FGEDGA+QG++ +
Sbjct  62   DSLPAILSPDRKTHGLLV-MKESEY---ETRR----IDVAFPVLHGKFGEDGAIQGLFVL  113

Query  122  LAVPFVGADVLASAACMDKDVTKRLLRDAGIAVAPFMVLSRGETLSFADAATQLGLPMFV  181
             ++P+VG D+ +SAACMDK ++  L ++AGIAV+ F ++ +G+       A  L  P+FV
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDK----PEAGALTYPVFV  169

Query  182  KPANQGSSVGVSKVSDEAGFVAALALGFEFDHKLLIEQGIVGREVECAVLGNFDAQVSVC  241
            KPA  GSS GV+KV++   + AA+  + ++D K+LIEQ+I G EV CAV+GN + ++ V 
Sbjct  170  KPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGN-EDDLIV-  227

Query  242  GEV----IANDEFYAYDTKYLN--GDQARIAIPAEFPADLSDQVREVALQAYKVLGCAGL  295
            GEV    ++++ F   + +  +  +++A I++PA++P +  ++V+E A + Y+VLGC GL
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  SRVDFFVTDTRDIIINEVNTLPGFTSISMYPKLWQASGLTYAELIHRLIVLALER  350
            +RVD+F+ +  +I++NEVNT+PGFTS S YP++  A+G+T + LI+ LI LAL R
Sbjct  288  ARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

50) Olsu_1201 in NC_014363


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  194 bits (720),  Expect = 8e-51, Method: Compositional matrix adjust.
 Identities = 149/349 (43%), Positives = 226/349 (65%), Gaps = 15/349 (4%)

Query  3    ERLNVALLFGGTSSEHDVSLRSAANVI-DLLSERVDLTLVGITRGGSWLLYGGDATAIAD  61
            +R++VA++FGG S EHDVS++SA ++  ++ +E+ D   +GIT+ G W L     T    
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTE---  58

Query  62   DSWQGHDTTPVCAVPGDGGGLFAVEGGSPVRLPIDVVFPVLHGQGGEDGVTQGLLESCRL  121
              W+++   ++ +      GL+ +  +      IDV FPVLHG+ GEDG  QGL+    +
Sbjct  59   --WEADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGI  116

Query  122  PYVGCGVLSSALCTDKDAAHRIVAAAGIRSPRCEVVHPGDGATRIAEVAAACGYPLFVKP  181
            PYVGC++ SSA C DK  A  +   AGI  P  ++++ GD +      A+A  YP+FVKP
Sbjct  117  PYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPE-----AGALTYPVFVKP  171

Query  182  ARGGSSYGVSKVEGPEQLDEALGLAFGYDEKVAVEEAIVGTEVGCaimggaagelamglV  241
            AR+GSS+GV+KV+G E+L+ A+  A  YD K+ +E+AI G EVGCA+MG   + +    V
Sbjct  172  ARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGE-V  230

Query  242  DETVVSDGGFFHIHQDHSEGADASTRNSSTRCPALLPPEVMERVRETGTAVWRALGCSGL  301
            D+  +S+G +F+IHQ++   ++ ++ N+    PA +P E  +RV+ET+  V R LGC GL
Sbjct  231  DQIRLSHG-IFRIHQENE--PEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  302  ARVDLFVTERGEVVFNEVNTMPGLTSYSRFPammaaagadmgEVLERLV  350
            ARVDLF+ E G +V+NEVNTMPG+TSYSR+P M+AAAG  +  +++ L+
Sbjct  288  ARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLI  336

51) ddl in NC_007005


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  192 bits (713),  Expect = 3e-50, Method: Compositional matrix adjust.
 Identities = 146/355 (42%), Positives = 232/355 (66%), Gaps = 21/355 (5%)

Query  2    KKSVAIVFGGQSSEHEVSLQSARNVINAIDRERYALTLIGVDKLGRWLHFDEADYLLNAT  61
            +  VAI+FGG S EH+VS++SA ++   ID E++    IG+ K G W  +         +
Sbjct  3    RIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVW-KLCKKPCTEWEA  61

Query  62   DPARIKLSASGKPLSLLPGSIGGQFVDVESGQPLAAIDVVFPLIHGAFGEDGALQGLLRM  121
            D+    LS+  K  +LL        V  ES      IDV FP++HG FGEDGA+QGL+ +
Sbjct  62   DSLPAILSPDRKTHGLL--------VMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVL  113

Query  122  LSVPFVGADVLSSAACMDKDVTKRLLRDAGIAVAPFRVLSRGESLSFTEAADQLGLPMFV  181
             ++P+VG D+ SSAACMDK ++  L ++AGIAV+ F+++ +G+       A+ L  P+FV
Sbjct  114  SGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD----KPEAGALTYPVFV  169

Query  182  KPANQGSSVGVSKVSDeagfaaalalgfefDHKLLIEQGIVGREVECAVLGNFDAQVSVC  241
            KPA  GSS GV+KV++   + AA+  + ++D K+LIEQ+I G EV CAV+GN + ++ V 
Sbjct  170  KPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGN-EDDLIV-  227

Query  242  GEV----IANDEFYAYDTKYLN--GDQARIAIPAELPADLSDQVRDVALQAYKVLGCAGL  295
            GEV    ++++ F   + +  +  +++A I++PA++P +  ++V++ A + Y+VLGC GL
Sbjct  228  GEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGL  287

Query  296  SRVDFFVTEGRDIIINEVNTLPGFTSISMYPKLWQASGLSYAELIHRLIVLALER  350
            +RVD+F+ E+ +I++NEVNT+PGFTS S YP++  A+G++ + LI+ LI LAL R
Sbjct  288  ARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

52) ddl in NC_002678


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  190 bits (706),  Expect = 1e-49, Method: Compositional matrix adjust.
 Identities = 146/358 (41%), Positives = 234/358 (66%), Gaps = 22/358 (6%)

Query  2    KEKTRVAILYGGRSAEHDVSRLSAANVLKAIDRTRYEVVPIAISRDGRWRL--QPSSEAG  59
             ++ +VAI++GG S EHDVS  SA ++   ID  +++   I+I+++G W+L  +P +E  
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE  60

Query  60   ADGAGAQVPEDGVEVALLPGGKGRLVALTKNGE-QPDPVDVVFPVLHGPFGEDGSVQGYA  118
            AD+         +   L P+ K + + + K++E +   +DV FPVLHG FGEDG++QG  
Sbjct  61   ADS---------LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLF  111

Query  119  EVADVAYVGCGILASAAAMDKDVAKRLLREAGLAVARSVTVLKGDVGSFQEIAGALGLPF  178
             +++++YVGC+I +SAA MDK +A  L ++AG+AV+    + KGD    +  AGAL  P 
Sbjct  112  VLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD----KPEAGALTYPV  167

Query  179  FAKPARQGSSFGVSKVHDRDGFEQAVETALRYDSKALIEEFVDGREIECSVLERADGSLT  238
            F KPAR GSSFGV+KV++ + ++ A+E+A +YD+K LIE+ + G E+ C+V+   D+ L 
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDD-LI  226

Query  239  VSPPGEIIPADKHGFYTYEAKY---FDAEGavvkvpadvpadvvaRTSEMAARAFRALGC  295
            V+  ++I  +  HG++  +       ++E A++ VPAD+P +   R  E A + +R LGC
Sbjct  227  VGEVDQIRLS--HGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGC  284

Query  296  EAMARVDFFLRADGSLLVNEVNTLPGFTDISMYAKALAAAGIGYSKVIDVLIEHALAR  353
             ++ARVD+FL+ DG++++NEVNT+PGFT  S Y++ +AAAGI  + +ID LI  AL R
Sbjct  285  RGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

53) ddl in NC_011985


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  189 bits (702),  Expect = 2e-49, Method: Compositional matrix adjust.
 Identities = 145/358 (41%), Positives = 228/358 (64%), Gaps = 25/358 (6%)

Query  3    SRLRVAVLFGGQSSEHDVSLMSARNVIKAIDVDKYEIVPIVIRRDGQWLL-----TALEG  57
            +R++VA++FGG S EHDVS+ SA ++   ID +K++   I I ++G W L     T  E+
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWEA  61

Query  58   GALPDPVVYAGSEVCLLPGGKGRILAVGDPTGPRELPAIDILFPVLHGLYGEDGSIQGLA  117
            ++LP           L P+ K + L V   +   E   ID+ FPVLHG +GEDG+IQGL 
Sbjct  62   DSLPAI---------LSPDRKTHGLLVMKESE-YETRRIDVAFPVLHGKFGEDGAIQGLF  111

Query  118  RMVGVPLVGCGILGSATAIDKDIAKRLLRDAGLPVARSITVRPGDTLSFEEAASALGSPV  177
             + G+P VGC+I +SA+ +DK +A  L ++AG++V+    +  GD       A+AL  PV
Sbjct  112  VLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDK----PEAGALTYPV  167

Query  178  FVKPVRQGSSVGVSKAANAEEFRAALIEAFKHDDKVLIEEFVKAREIECAVLEQTDGTLF  237
            FVKP R GSS GV+K   +EE+ AA+  A + D+K+LIE+ + + E+ CAV+ + D+ L+
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDD-LI  226

Query  238  VSLPGEIVTGQDHSFYTYDAKYIDEDG---AITSVPAQLPADLTQHLRELSLDAFRALGC  294
            V+  ++I  +  H+++  +     E G   A+ +VPA++P +  ++++E +   +R LGC
Sbjct  227  VGEVDQIRLS--HGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGC  284

Query  295  EGLARVDFFVRPDMSMVVNEVNTMPGFTNISMYPKAMEATGISYPALVDRLIEHGLAR  352
             GLARVD+F++ D ++V+NEVNTMPGFT+ S YP+ + A+GI+ PAL+D LI  +L R
Sbjct  285  RGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

54) Mesau_03231 in NC_019973


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  177 bits (655),  Expect = 1e-45, Method: Compositional matrix adjust.
 Identities = 144/358 (41%), Positives = 230/358 (65%), Gaps = 22/358 (6%)

Query  3    GKIRVAILYGGRSAEHDVSRLSAANVLKAIDRTRYEVVPIAISREGRWLL--QPASEAIG  60
             +I+VAI++GG S EHDVS  SA ++   ID  +++   I+I+++G W L  +P +E  +
Sbjct  2    NRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWEA  61

Query  61   EGAGAPVSQDGMEIALLPGGKGRLISASPMGTRADLAPVDVVFPVLHGPFGEDGSVQGYA  120
            ++  A +S D    +LL      ++  S   TR     +DV FPVLHG FGEDG++QG  
Sbjct  62   DSLPAILSPDRKTHGLL------VMKESEYETR----RIDVAFPVLHGKFGEDGAIQGLF  111

Query  121  EVADVAYVGSGILASAAAMDKDVAKRLMQGAGLAVARSVTVHRNDVGSFQEIAGALGLPF  180
             +++++YVG +I +SAA MDK +A  L + AG+AV+    +++ D    +  AGAL  P 
Sbjct  112  VLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGD----KPEAGALTYPV  167

Query  181  FAKPARQGSSFGVSKVNDRDGFDQAVETAFRYDGKALIEEFVEGREIECSVLQRADGSLT  240
            F KPAR GSSFGV+KVN+ + ++ A+E+A +YDGK LIE+ + G E+ C+V+   D+ L 
Sbjct  168  FVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDD-LI  226

Query  241  VSLPGEIIPAGKHGFYTYEAKY---LdadgavvkvpadvpaavidRAREMAGQAFKALGC  297
            V+  ++I  +  HG++  +       +++ A++ VPAD+P    +R +E A + ++ LGC
Sbjct  227  VGEVDQIRLS--HGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGC  284

Query  298  EAMARVDFFLRADGSLLVNEVNTLPGFTDISMYAKALAAIGIGYSEVIDILIEHALAR  355
             ++ARVD+FL+ DG++++NEVNT+PGFT  S Y++ +AA GI  + +ID LI  AL R
Sbjct  285  RGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

55) EC1_04100 in NC_021019


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  169 bits (624),  Expect = 3e-43, Method: Compositional matrix adjust.
 Identities = 139/347 (41%), Positives = 211/347 (61%), Gaps = 14/347 (4%)

Query  2    LKLGVVFGGQSSEYSVSLHSVASFLRQIHNEKYDITMIGIDQNGQFYVYDGSIDDIEHDH  61
            +K++++FGG S E  VS+ S   +  +I+ EK+D   IGI +NG   +   +  + E D 
Sbjct  4    IKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWEADS  63

Query  62   WIPQATKAAWVHKGIMALDGKN-TVKELDCVFPVLHGKNGEDGCVQGLLELMNIHYVGCD  120
             +P    + +   G++ +   +   + +D  FPVLHGK GEDG +QGL+ L  I YVGCD
Sbjct  64   -LPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCD  122

Query  121  VMSSAISMDKEIMHILCDEANIPCADYVCLKANEENPSFEMIQEKISLPWIVKPCNAGSS  180
            + SSA  MDK +  IL  +A I+ +++  +   +   +       ++ P +VKP  +GSS
Sbjct  123  IQSSAACMDKSLAYILTKNAGIAVPEFQIIDKGDKPEA-----GALTYPVFVKPARSGSS  177

Query  181  YGVHKVENKEEFEEACKDAFFYDGRGKILVEKAIEGFEIGCAVMGNE-EVFTGSCDEIQI  239
            +GV KV+  EE++ A   A  YD  GKIL+E+AI G E+GCAVMGNE +++ G  D+I++
Sbjct  178  FGVTKVNGTEELNAAIEAAGQYD--GKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRL  235

Query  240  SGGIFDFEGKYEM-KGAE---IICPARIDEETFakakalaaktykaMNCCGMARVDMFVT  295
            S GIF ++   E  KG+E   I  PA I  E   + +  A K Y+ + C G+ARVD+F+ 
Sbjct  236  SHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQ  295

Query  296  PQKEVILNELNTIPGFTATSRYPSMMKEAGIEFGDLIDKLIDLAMQR  342
             +  ++LNE+NT+PGFT+ SRYP M+  AGI +  LID LI LA++R
Sbjct  296  EDGGIVLNEVNTMPGFTSYSRYPRMVAAAGITLPALIDSLITLALKR  342

56) ddl in NC_011060


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  163 bits (604),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 141/352 (41%), Positives = 220/352 (63%), Gaps = 31/352 (8%)

Query  1    MPRITVALIFGGRSTEHEisiisaksiaanisaERYKVIPLYI--THQGTW-LCEGIARD  57
            M RI VA+IFGG S EH++S+ SA  IAANI +E++   P YI  T +G W LC     +
Sbjct  1    MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFD--PHYIGITKNGVWKLCKKPCTE  58

Query  58   ILNLDLSALLRNSSPEAAAMALDRMVEEAEQKPFNLDFRAIGIEVAFLTLHGTYGEDGRI  117
                 L+A+L   SP+  + +L  M E         ++ +  I+VAF  LHG +GEDG I
Sbjct  59   WEADSLPAIL---SPDRKTHGLLVMKES--------EYETRRIDVAFPVLHGKFGEDGAI  107

Query  118  QGFLDTCNIPYTGCGVLASALTMDKALTKLCVADAGIAVAPSITLLSAEYHADTEKVHSR  177
            QG++    IPY GC++ +SA  MDK+L+ +   +AGIAV        +E++   +K +  
Sbjct  108  QGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAV--------PEFQI-IDKGDKP  158

Query  178  IEEKFIYPFFVKPANLGSSIGISKVHHREQLPAALKSACSLDSKIVVEKAITGREIEVAV  237
                + YP FVKPA  GSS+G++KV+  E+L AA+ +A   D+KI++E+AI+G E+  AV
Sbjct  159  EAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAV  218

Query  238  LGNDEP-EVSVCGEIEPGSDFYDYHDKYIH----NSAKLFIPARIPDEMQSEVRSIALKA  292
            +GN++   V+  ++I  + +++  H+        ++A + +PA IP E ++ V+  A K 
Sbjct  219  MGNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKV  278

Query  293  YKALGCRGMSRIDFFVDEKRGTIVLNEVNTIPGFTDISMFPRLMAASGHSFP  344
            Y+ LGCRG++R+D+F++E  G IVLNEVNT+PGFT  S +PR++AA+G ++P
Sbjct  279  YRVLGCRGLARVDLFLQED-GGIVLNEVNTMPGFTSYSRYPRMVAAAGITLP  329

57) ddl in NC_009921


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  157 bits (581),  Expect = 8e-40, Method: Compositional matrix adjust.
 Identities = 113/259 (44%), Positives = 171/259 (67%), Gaps = 11/259 (4%)

Query  107  VDVVFPLLHGPFGEDGTIQGLLEMAGLPYVGSGVFASAAAMDKQHMKSMLAAAGLPVGPY  166
            +DV FP+LHG FGEDG+IQGL+ ++G+PYVG ++ +SAA MDK     +   AG++V  +
Sbjct  90   IDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPEF  149

Query  167  AVLRPGQALSEPDRERLGLPVFVKPARGGSSIGISRVDAWADLDTALKTARASDPKTLVE  226
             ++  G+    P+   L  PVFVKPAR+GSS+G+++V++  +L++A+ +A   D K L+E
Sbjct  150  QIIDKGD---KPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIE  206

Query  227  AAVVGREIECGVLDSLDGSGPQASVPAEVTITSSAGFY----DFEAKYLSDGAVFDVPAR  282
             A+ G E+ C+V+    G+  +  V     I  S G++    + E+   S+ A++ VPA 
Sbjct  207  QAISGCEVGCAVM----GNEDDLIVGEVDQIRLSHGIFRIHQENEPEKGSENAMITVPAD  262

Query  283  LPGELTervraaavaafeaLDCAGLARVDMFVTPSGEIVLNEVNTMPGFTPMSMYPRMWA  342
            +P E  +RV+ +A   +  L+C GLARVD+F+   G IVLNEVNTMPGFT+ S YPRM A
Sbjct  263  IPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVA  322

Query  343  ASGIDYAALVDRLVQLALR  361
            A+GI  +AL+D L+ LAL+
Sbjct  323  AAGITLPALIDSLITLALK  341

58) ddl in NC_005835


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  153 bits (566),  Expect = 9e-39, Method: Compositional matrix adjust.
 Identities = 105/257 (41%), Positives = 168/257 (66%), Gaps = 14/257 (5%)

Query  73   RYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVP  132
            R DV FP+LHG+FGEDG++QG++ L G PYVG ++ +SA CMDK L+  +  +AG++V  
Sbjct  89   RIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPE  148

Query  133  WVAVRKGE-PSMVPFDPPFFVKPANTGSSVGISRVERFQDLEAALALAFRYDEKAVVEKA  191
               + KG+ P   ++  P FVKPA +GSS G+++V+  ++L+AA+  A +YD K ++E+A
Sbjct  149  FQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQA  208

Query  192  LSPVRELEVGVLGN----VFGEASPVGEVRYEAPFYDYETKYTPGRAE----LLIPAPLD  243
            +S   E+  +V+GN    + GE   V+++R    ++  +    P ++     + +PA + 
Sbjct  209  ISGC-EVGCAVMGNEDDLIVGE---VDQIRLSHGIFRIHQENEPEKGSENAMITVPADIP  264

Query  244  PGTQETVQELALKAYKVLGVRGMARVDFFL-AEGEVYLNELNTIPGFTPTSMYPRLFEAG  302
               ++ VQE A K Y+VLG RG+ARVD+FL  +G + LNE+NT+PGFT+ S YPR+  A+
Sbjct  265  VEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAA  324

Query  303  GVAYPELLRRLVELALT  319
            G++ P L+  L+ LAL 
Sbjct  325  GITLPALIDSLITLALK  341

59) ddl in NC_006461


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  139 bits (512),  Expect = 2e-34, Method: Compositional matrix adjust.
 Identities = 105/257 (41%), Positives = 166/257 (65%), Gaps = 14/257 (5%)

Query  73   RYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVP  132
            R DV FP+LHG+FGEDG++QG++ L G PYVG ++ +SA CMDK L+  +  +AG++V  
Sbjct  89   RIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPE  148

Query  133  WVAVRKGEppvvpfdp-pffvkpANTGSSVGISRVERFQDLEAALALAFRYDEKAVVEKA  191
               + KG+ P       P FVKPA +GSS G+++V+  ++L+AA+  A +YD K ++E+A
Sbjct  149  FQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQA  208

Query  192  LSPVRELEVGVLGN----VFGEASPVGEVRYEAPFYDYETKYTPGRAE----LLIPAPLD  243
            +S   E+  +V+GN    + GE   V+++R    ++  +    P ++     + +PA + 
Sbjct  209  ISGC-EVGCAVMGNEDDLIVGE---VDQIRLSHGIFRIHQENEPEKGSENAMITVPADIP  264

Query  244  PGTQETVQELALKAYKVLGVRGMARVDFFL-AEGELYLNELNTIPGFTPTSMYPRLFEAG  302
               ++ VQE A K Y+VLG RG+ARVD+FL  +G + LNE+NT+PGFT+ S YPR+  A+
Sbjct  265  VEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAA  324

Query  303  GVAYPELLRRLVELALT  319
            G++ P L+  L+ LAL 
Sbjct  325  GITLPALIDSLITLALK  341

60) TtJL18_0458 in NC_017587


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  139 bits (509),  Expect = 3e-34, Method: Compositional matrix adjust.
 Identities = 105/257 (41%), Positives = 166/257 (65%), Gaps = 14/257 (5%)

Query  73   RYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVP  132
            R DV FP+LHG+FGEDG++QG++ L G PYVG ++ +SA CMDK L+  +  +AG++V  
Sbjct  89   RIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPE  148

Query  133  WVAVRKGEppmvpfdp-pffvkpANTGSSVGISRVERFQDLEAALALAFRYDEKAVVEKA  191
               + KG+ P       P FVKPA +GSS G+++V+  ++L+AA+  A +YD K ++E+A
Sbjct  149  FQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQA  208

Query  192  LSPVRELEVGVLGN----VFGEASPVGEVRYEAPFYDYETKYTPGRAE----LLIPAPLD  243
            +S   E+  +V+GN    + GE   V+++R    ++  +    P ++     + +PA + 
Sbjct  209  ISGC-EVGCAVMGNEDDLIVGE---VDQIRLSHGIFRIHQENEPEKGSENAMITVPADIP  264

Query  244  PGTQETVQELALKAYKVLGVRGMARVDFFL-AEGELYLNELNTIPGFTPTSMYPRLFEAG  302
               ++ VQE A K Y+VLG RG+ARVD+FL  +G + LNE+NT+PGFT+ S YPR+  A+
Sbjct  265  VEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAA  324

Query  303  GVAYPELLRRLVELALT  319
            G++ P L+  L+ LAL 
Sbjct  325  GITLPALIDSLITLALK  341

61) Ththe16_1607 in NC_017272


> NC_021994_R1|53|G53|529233447|YP_008394259.1|Enterococcus_faecium_Aus0085|+|50843..51871|vanB|EFAU085_00735|Vancomycin 
B-type 
resistance protein vanB, D-alanine--D-lactate ligase
Length=342

 Score =  138 bits (508),  Expect = 4e-34, Method: Compositional matrix adjust.
 Identities = 105/257 (41%), Positives = 166/257 (65%), Gaps = 14/257 (5%)

Query  73   RYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVTASALCMDKDLSKRVLAQAGVPVVP  132
            R DV FP+LHG+FGEDG++QG++ L G PYVG ++ +SA CMDK L+  +  +AG++V  
Sbjct  89   RIDVAFPVLHGKFGEDGAIQGLFVLSGIPYVGCDIQSSAACMDKSLAYILTKNAGIAVPE  148

Query  133  WVAVRKGEppmvpfdp-pffvkpANTGSSVGISRVERFQDLEAALALAFRYDEKAVVEKA  191
               + KG+ P       P FVKPA +GSS G+++V+  ++L+AA+  A +YD K ++E+A
Sbjct  149  FQIIDKGDKPEAGALTYPVFVKPARSGSSFGVTKVNGTEELNAAIEAAGQYDGKILIEQA  208

Query  192  LSPVRELEVGVLGN----VFGEASPVGEVRYEAPFYDYETKYTPGRAE----LLIPAPLD  243
            +S   E+  +V+GN    + GE   V+++R    ++  +    P ++     + +PA + 
Sbjct  209  ISGC-EVGCAVMGNEDDLIVGE---VDQIRLSHGIFRIHQENEPEKGSENAMITVPADIP  264

Query  244  PGTQETVQELALKAYKVLGVRGMARVDFFL-AEGELYLNELNTIPGFTPTSMYPRLFEAG  302
               ++ VQE A K Y+VLG RG+ARVD+FL  +G + LNE+NT+PGFT+ S YPR+  A+
Sbjct  265  VEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGIVLNEVNTMPGFTSYSRYPRMVAAA  324

Query  303  GVAYPELLRRLVELALT  319
            G++ P L+  L+ LAL 
Sbjct  325  GITLPALIDSLITLALK  341