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PAthogenisity Island DataBase (PAI DB)

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Homologs of cadA gene of AF447814

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) SSON53_24945
( YP_005459463.1 )

lysine decarboxylase CadA

NC_016822
(Shigella sonnei 53G)

1e-159

2) ldcC
( YP_005395746.1 )

lysine decarboxylase

NC_017046
(Salmonella enterica 798)

3e-158

3) SFHH103_04620
( YP_006575634.1 )

K01584 arginine decarboxylase

NC_018299
(Sinorhizobium fredii HH103)

8e-51

• Sequence Alignments

1) SSON53_24945 in NC_016822


> AF447814|49|G49|18265908|AAL67381.1|Escherichia_coli_CFT073|-|37104..38432|cadA|-|lysine 
decarboxylase
Length=442

 Score =  555 bits (2094),  Expect = 1e-159, Method: Compositional matrix adjust.
 Identities = 337/338 (99%), Positives = 338/338 (100%), Gaps = 0/338 (0%)

Query  1    MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD  60
            MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD
Sbjct  14   MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD  73

Query  61   KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQT  120
            KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAA+DIANKIKQT
Sbjct  74   KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQT  133

Query  121  TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI  180
            TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI
Sbjct  134  TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI  193

Query  181  SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI  240
            SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
Sbjct  194  SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI  253

Query  241  DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH  300
            DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
Sbjct  254  DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH  313

Query  301  AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTN  338
            AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTN
Sbjct  314  AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTN  351

2) ldcC in NC_017046


> AF447814|49|G49|18265908|AAL67381.1|Escherichia_coli_CFT073|-|37104..38432|cadA|-|lysine 
decarboxylase
Length=442

 Score =  551 bits (2080),  Expect = 3e-158, Method: Compositional matrix adjust.
 Identities = 307/426 (73%), Positives = 378/426 (89%), Gaps = 0/426 (0%)

Query  1    MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD  60
            MN+IAI+   GVY+K+EPI+EL+RAL+ L FQI+ P++  DLLK+IE+N+R+CGVIFDWD
Sbjct  14   MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD  73

Query  61   EYSLDLCSEINQLNEYLPLYAFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQY  120
             Y+L+LC EI+++NE LPLYAF NT STLDVS++D+R+ + FFEYALG A+DIA +I Q 
Sbjct  74   KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQT  133

Query  121  TNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTAYQKSPPGCLFYDFFGGNTLKADV  180
            T+EY++ I PP+TKALF Y +EGKYTFCTPGHM+GTA+QKSP G LFYDFFG NT+K+D+
Sbjct  134  TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI  193

Query  181  SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI  240
            SISV+ELGSLLDH+GPH EAE+YIAR F A++SYMVTNGTST+NKIVGMY+APAGST+LI
Sbjct  194  SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI  253

Query  241  DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRASIESKIEETPQAQWPVH  300
            DRNCHKSL+HL+MMSDV P+ ++PTRNA GILGGIP+ EF +A+I  ++ ETP+A WPVH
Sbjct  254  DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH  313

Query  301  AVITNSTYDGLLYNTNWIKQMLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIF  360
            AVITNSTYDGLLYNT+ IK+ LDV SIHFDSAWVPYT+F PIY+GK GMSG+RV GKVI+
Sbjct  314  AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIY  373

Query  361  ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNP  420
            ETQSTHK+LAAFSQAS+IH+KG+ +EETFNEA+MMHT+TSP Y IVAS ETAAAM++GN+
Sbjct  374  ETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNA  433

Query  421  GKRLIN  426
            GKRLIN
Sbjct  434  GKRLIN  439

3) SFHH103_04620 in NC_018299


> AF447814|49|G49|18265908|AAL67381.1|Escherichia_coli_CFT073|-|37104..38432|cadA|-|lysine 
decarboxylase
Length=442

 Score =  194 bits (719),  Expect = 8e-51, Method: Compositional matrix adjust.
 Identities = 146/333 (44%), Positives = 221/333 (67%), Gaps = 12/333 (3%)

Query  76   WQILAEVLAAKRSR-NDRLPIFLFGDGTTAEMVPANVLHHADAFMRLFEDSAEFMARAIV  134
            W+     L    S+ N+ LP++ F++  ++  V+ N L+   +F     ++A+ +A  I 
Sbjct  72   WDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIK  131

Query  135  SHARNYLERLPPPMFKALMEYTLHAAYSWHTPGHGGGVAFRKSPVGQLFYTFFGENTLRS  194
              + +Y++ + PP+ KAL  Y  ++ Y+  TPGH GG AF+KSPVG LFY FFG NT++S
Sbjct  132  QTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKS  191

Query  195  DIsvsvgslgsllDHTGPIAEGERNATRIFGADQTFFVVGGTSAANKIVWHGTVSRGDLV  254
            DIS+SV+ LGSLLDH+GP  E+E+  +R+F AD+++ V  GTS+ANKIV   + + G  +
Sbjct  192  DISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTI  251

Query  255  LCDRNCHKSILHALIMTGAVPIYLTPSRNGLGIIGPIAQDQFTPEAIAQKIAASPFAG-K  313
            L DRNCHKS+ H ++M++  PIY+ P+RN+ GI+G I+Q +F   +IA+++  +P A   
Sbjct  252  LIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWP  311

Query  314  ANGKVRLMVVTNSTYDGLCYNVDGIKESLGDTVDVLHFDEAWYAYANFHEFYDGYHAISS  373
             ++     V+TNSTYDGL YN D IK +L+  V  +HFD AW +Y+NF  +Y+G  ++S+
Sbjct  312  VHA-----VITNSTYDGLLYNTDFIKKTLD--VKSIHFDSAWVPYTNFSPIYEGKCGMSG  364

Query  374  SRPSRSPHAITVATQSTHKFLAAFSQASMIHVQ  406
            +R       +   TQSTHK+LAAFSQASMIHV+
Sbjct  365  GRVEGK---VIYETQSTHKLLAAFSQASMIHVK  394

4) adiA in NC_018191


> AF447814|49|G49|18265908|AAL67381.1|Escherichia_coli_CFT073|-|37104..38432|cadA|-|lysine 
decarboxylase
Length=442

 Score =  194 bits (719),  Expect = 8e-51, Method: Compositional matrix adjust.
 Identities = 146/333 (44%), Positives = 221/333 (67%), Gaps = 12/333 (3%)

Query  76   WQILAEVLAAKRSR-NDRLPIFLFGDGTTAEMVPANVLHHADAFMRLFEDSAEFMARAIV  134
            W+     L    S+ N+ LP++ F++  ++  V+ N L+   +F     ++A+ +A  I 
Sbjct  72   WDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIK  131

Query  135  SHARNYLERLPPPMFKALMEYTLHAAYSWHTPGHGGGVAFRKSPVGQLFYTFFGENTLRS  194
              + +Y++ + PP+ KAL  Y  ++ Y+  TPGH GG AF+KSPVG LFY FFG NT++S
Sbjct  132  QTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKS  191

Query  195  DIsvsvgslgsllDHTGPIAEGERNATRIFGADQTFFVVGGTSAANKIVWHGTVSRGDLV  254
            DIS+SV+ LGSLLDH+GP  E+E+  +R+F AD+++ V  GTS+ANKIV   + + G  +
Sbjct  192  DISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTI  251

Query  255  LCDRNCHKSILHALIMTGAVPIYLTPSRNGLGIIGPIAQDQFTPEAIAQKIAASPFAG-K  313
            L DRNCHKS+ H ++M++  PIY+ P+RN+ GI+G I+Q +F   +IA+++  +P A   
Sbjct  252  LIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWP  311

Query  314  ANGKVRLMVVTNSTYDGLCYNVDGIKESLGDTVDVLHFDEAWYAYANFHEFYDGYHAISS  373
             ++     V+TNSTYDGL YN D IK +L+  V  +HFD AW +Y+NF  +Y+G  ++S+
Sbjct  312  VHA-----VITNSTYDGLLYNTDFIKKTLD--VKSIHFDSAWVPYTNFSPIYEGKCGMSG  364

Query  374  SRPSRSPHAITVATQSTHKFLAAFSQASMIHVQ  406
            +R       +   TQSTHK+LAAFSQASMIHV+
Sbjct  365  GRVEGK---VIYETQSTHKLLAAFSQASMIHVK  394