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PAthogenisity Island DataBase (PAI DB)

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Homologs of EFAU085_00720 gene of NC_021994_R1

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) EFAU004_02790
( YP_005355988.1 )

DNA topoisomerase III

NC_017022
(Enterococcus faecium Aus0004)

0.0

100

2) EFAU085_00720
( YP_008394244.1 )

DNA topoisomerase III

NC_021994
(Enterococcus faecium AUS0085)

0.0

100

3) ES1_15040
( YP_007839991.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021043
(Eubacterium siraeum V10Sc8a)

0.0

4) RBR_01000
( YP_007780333.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021013
(Ruminococcus bromii L2-63)

0.0

5) CLS_29900
( YP_007850277.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021047
(Clostridium saccharolyticum K10)

0.0

6) topB
( YP_001087593.1 )

DNA topoisomerase III

NC_009089
(Clostridium difficile 630)

0.0

7) CK5_22580
( YP_007805585.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021022
([Ruminococcus] obeum A2-162)

0.0

8) FPR_01100
( YP_007798966.1 )

Topoisomerase IA

NC_021020
(Faecalibacterium prausnitzii SL3/3)

0.0

9) CK5_29340
( YP_007806168.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021022
([Ruminococcus] obeum A2-162)

0.0

10) RBR_21180
( YP_007782015.1 )

Topoisomerase IA

NC_021013
(Ruminococcus bromii L2-63)

0.0

11) CLS_04840
( YP_007848302.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021047
(Clostridium saccharolyticum K10)

0.0

12) CCU_07970
( YP_007795898.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021018
(Coprococcus sp. ART55/1)

0.0

13) RHOM_15375
( YP_004840113.1 )

DNA topoisomerase III

NC_015977
(Roseburia hominis A2-183)

0.0

14) topB-2
( NP_815968.1 )

DNA topoisomerase III

NC_004668
(Enterococcus faecalis V583)

0.0

15) EUBREC_3570
( YP_002939430.1 )

DNA topoisomerase

NC_012781
(Eubacterium rectale ATCC 33656)

0.0

16) EUR_07600
( YP_007772051.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021010
(Eubacterium rectale DSM 17629)

1e-177

17) RTO_00720
( YP_007785385.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021015
([Ruminococcus] torques L2-14)

9e-177

18) EUS_14250
( YP_007775462.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021011
(Eubacterium siraeum 70/3)

2e-176

19) FPR_14240
( YP_007800103.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021020
(Faecalibacterium prausnitzii SL3/3)

2e-176

20) Ethha_1903
( YP_004092156.1 )

DNA topoisomerase III

NC_014828
(Ethanoligenens harbinense YUAN-3)

3e-176

21) FP2_09300
( YP_007836783.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021042
(Faecalibacterium prausnitzii L2/6)

4e-176

22) EC1_10280
( YP_007798169.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021019
(Eubacterium cylindroides T2-87)

7e-176

23) RHOM_01890
( YP_004837432.1 )

DNA topoisomerase III

NC_015977
(Roseburia hominis A2-183)

3e-175

24) topB
( YP_004882732.1 )

DNA topoisomerase III

NC_016048
(Oscillibacter valericigenes Sjm18-20)

7e-171

25) CK5_35660
( YP_007806715.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021022
([Ruminococcus] obeum A2-162)

2e-169

26) Closa_3709
( YP_003823852.1 )

DNA topoisomerase III

NC_014376
(Clostridium saccharolyticum WM1)

6e-165

27) CK5_04590
( YP_007804031.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021022
([Ruminococcus] obeum A2-162)

1e-159

28) CC1_26110
( YP_007770654.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021009
(Coprococcus catus GD/7)

4e-159

29) FP2_00540
( YP_007836050.1 )

DNA topoisomerase III, bacteria and conjugative plasmid

NC_021042
(Faecalibacterium prausnitzii L2/6)

1e-156

30) topB
( YP_006912025.1 )

DNA topoisomerase III

NC_018867
(Dehalobacter sp. CF)

2e-151

31) SII_1009
( YP_008497180.1 )

putative DNA topoisomerase

NC_022237
(Streptococcus intermedius C270)

2e-123

32) SCI_1283
( YP_008499205.1 )

putative DNA topoisomerase

NC_022238
(Streptococcus constellatus C1050)

5e-123

33) SCRE_1224
( YP_008495615.1 )

putative DNA topoisomerase

NC_022236
(Streptococcus constellatus C232)

5e-123

34) SCR2_1224
( YP_008511377.1 )

putative DNA topoisomerase

NC_022245
(Streptococcus constellatus C818)

5e-123

35) CD630_04210
( YP_001086889.1 )

DNA topoisomerase protein, type IA,Tn1549-like,CTn2-Orf16

NC_009089
(Clostridium difficile 630)

3e-121

36) SANR_1345
( YP_008501051.1 )

putative DNA topoisomerase

NC_022239
(Streptococcus anginosus C238)

5e-121

37) SZO_12820
( YP_002744799.1 )

DNA topoisomerase

NC_012470
(Streptococcus equi H70)

5e-121

38) SANR_1304
( YP_008501012.1 )

putative DNA topoisomerase

NC_022239
(Streptococcus anginosus C238)

6e-121

39) topB
( NP_350150.1 )

topoisomerase B

NC_003030
(Clostridium acetobutylicum ATCC 824)

1e-120

40) SMB_G3608
( YP_004638221.1 )

topoisomerase B

NC_015687
(Clostridium acetobutylicum DSM 1731)

1e-120

41) topB
( YP_005672706.1 )

Topoisomerase B

NC_017295
(Clostridium acetobutylicum EA 2018)

1e-120

42) SDSE_1343
( YP_006904895.1 )

DNA topoisomerase III

NC_019042
(Streptococcus dysgalactiae AC-2713)

2e-120

43) SDE12394_07175
( YP_006013463.1 )

DNA topoisomerase

NC_017567
(Streptococcus dysgalactiae ATCC 12394)

2e-120

44) CD630_18590
( YP_001088366.1 )

DNA topoisomerase protein, type IA,Tn1549-like,CTn5-Orf16

NC_009089
(Clostridium difficile 630)

3e-120

45) topA
( YP_006859871.1 )

DNA topoisomerase III

NC_018712
(Streptococcus dysgalactiae RE378)

2e-119

46) HMPREF0389_00190
( YP_005054189.1 )

DNA topoisomerase III

NC_016630
(Filifactor alocis ATCC 35896)

4e-119

47) SEQ_1256
( YP_002746546.1 )

DNA topoisomerase

NC_012471
(Streptococcus equi 4047)

9e-119

48) CDR20291_1793
( YP_003218283.1 )

DNA topoisomerase

NC_013316
(Clostridium difficile R20291)

5e-118

49) SIR_0986
( YP_008512919.1 )

putative DNA topoisomerase

NC_022246
(Streptococcus intermedius B196)

1e-117

50) SANR_1853
( YP_008501522.1 )

putative DNA topoisomerase

NC_022239
(Streptococcus anginosus C238)

3e-116

51) Dtox_2001
( YP_003191459.1 )

DNA topoisomerase III

NC_013216
(Desulfotomaculum acetoxidans DSM 771)

7e-116

52) SAIL_7480
( YP_008117367.1 )

DNA topoisomerase III

NC_021507
(Streptococcus agalactiae ILRI112)

4e-113

53) Swol_0497
( YP_753202.1 )

DNA topoisomerase

NC_008346
(Syntrophomonas wolfei Goettingen)

2e-111

54) SPAP_0887
( YP_003876478.1 )

topoisomerase IA

NC_014494
(Streptococcus pneumoniae AP200)

6e-111

55) HMPREF0389_00657
( YP_005054797.1 )

DNA topoisomerase III

NC_016630
(Filifactor alocis ATCC 35896)

2e-110

56) DCF50_p701
( YP_006912693.1 )

DNA topoisomerase III

NC_018867
(Dehalobacter sp. CF)

3e-110

57) DHBDCA_p643
( YP_006909657.1 )

DNA topoisomerase III

NC_018866
(Dehalobacter sp. DCA)

3e-110

58) MGAS10750_Spy1696
( YP_603190.1 )

DNA topoisomerase III

NC_008024
(Streptococcus pyogenes MGAS10750)

2e-109

59) FMG_0956
( YP_001692264.1 )

DNA topoisomerase III

NC_010376
(Finegoldia magna ATCC 29328)

6e-109

60) Apre_1822
( YP_003142397.1 )

DNA topoisomerase type IA central domain-containing protein

NC_013164
(Anaerococcus prevotii DSM 20548)

9e-109

61) SIR_1325
( YP_008513256.1 )

putative DNA topoisomerase

NC_022246
(Streptococcus intermedius B196)

2e-107

62) Ccel_0922
( YP_002505269.1 )

DNA topoisomerase III

NC_011898
(Clostridium cellulolyticum H10)

9e-107

63) Sinac_2513
( YP_007202515.1 )

DNA topoisomerase III

NC_019892
(Singulisphaera acidiphila DSM 18658)

2e-105

64) topB1
( YP_005958423.1 )

DNA topoisomerase III

NC_017542
(Paenibacillus polymyxa M1)

4e-105

65) PPSC2_c0842
( YP_003945066.1 )

DNA topoisomerase

NC_014622
(Paenibacillus polymyxa SC2)

4e-105

66) Clo1100_3206
( YP_005149158.1 )

DNA topoisomerase III

NC_016791
(Clostridium sp. BNL1100)

4e-105

67) topB
( YP_007401974.1 )

DNA topoisomerase III

NC_020210
(Geobacillus sp. GHH01)

6e-105

68) Sgly_2022
( YP_004266316.1 )

DNA topoisomerase III

NC_015172
(Syntrophobotulus glycolicus DSM 8271)

1e-104

69) GYMC52_1650
( YP_004132230.1 )

DNA topoisomerase III

NC_014915
(Geobacillus sp. Y412MC52)

3e-104

70) GYMC61_2520
( YP_003253597.1 )

DNA topoisomerase III

NC_013411
(Geobacillus sp. Y412MC61)

3e-104

71) PPE_00753
( YP_003869141.1 )

topoisomerase IA

NC_014483
(Paenibacillus polymyxa E681)

2e-103

72) KNP414_02988
( YP_004641416.1 )

DNA topoisomerase III

NC_015690
(Paenibacillus mucilaginosus KNP414)

4e-99

73) PM3016_3225
( YP_005313229.1 )

DNA topoisomerase III

NC_016935
(Paenibacillus mucilaginosus 3016)

8e-99

74) B2K_16715
( YP_006190108.1 )

DNA topoisomerase III

NC_017672
(Paenibacillus mucilaginosus K02)

8e-99

75) FPR_19060
( YP_007800526.1 )

Topoisomerase IA

NC_021020
(Faecalibacterium prausnitzii SL3/3)

1e-93

• Sequence Alignments

1) EFAU004_02790 in NC_017022


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score = 1030 bits (3906),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 693/693 (100%), Positives = 693/693 (100%), Gaps = 0/693 (0%)

Query  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60
            MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120
            WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180
            AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDaaeantv  240
            LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  241  kaacakaqavcvsvTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300
            KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL
Sbjct  241  KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360
            TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  361  EFVKQGFGTLAESEkkllslicckllcAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420
            EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480
            WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540
            AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE
Sbjct  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540

Query  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP  600
            ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP
Sbjct  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP  600

Query  601  IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIaaallktgkvkvk  660
            IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVK
Sbjct  601  IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVK  660

Query  661  glYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS  693
            GLYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS
Sbjct  661  GLYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS  693

2) EFAU085_00720 in NC_021994


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score = 1030 bits (3906),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 693/693 (100%), Positives = 693/693 (100%), Gaps = 0/693 (0%)

Query  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60
            MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120
            WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180
            AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDaaeantv  240
            LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  241  kaacakaqavcvsvTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300
            KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL
Sbjct  241  KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360
            TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  361  EFVKQGFGTLAESEkkllslicckllcAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420
            EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480
            WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540
            AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE
Sbjct  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540

Query  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP  600
            ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP
Sbjct  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP  600

Query  601  IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIaaallktgkvkvk  660
            IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVK
Sbjct  601  IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVK  660

Query  661  glYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS  693
            GLYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS
Sbjct  661  GLYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS  693

3) ES1_15040 in NC_021043


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  801 bits (3032),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 464/688 (68%), Positives = 573/688 (84%), Gaps = 1/688 (0%)

Query  2    KLVIAEKPSVGAAIAAVMGANEKRSGYFEGGGYLVSWCIGHLISLADAATYNEQFRKWKY  61
            KLVIAEKPSV+ +IA+V+GA EK+ GY+EG GYLVSWCIGHL+S+ADA+ Y+E+F+KW+Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPIVPQEWQFIVASGKEQQFSILKDLMHRSDVTEIINACDSGREGELIFRFVYEQANC  121
            +DLPI+P+ WQ+IV+ +K QQF +L  LM+R+DVT ++ A D+GREGELIFRFVY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPFSRLWISSMEASAIREGFSNLKDGRGYDNLYQSALCRAKADWLIGINATRLFSILYH  181
            +KPF RLWISSME SAI++GF++LK G +YD LYQSALCRAKADWLIGINATRLFS+LYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  KTLNVGRVQTPTLAMLVNRDYAISSFKKEKYHVVRLDVGGVAALSERQDDEAAARQMKAA  241
            K L VGRVQTPTL MLV+RD  I+ FKKEKYH+V++  GG  A+S R  D A A  +KAA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CEKSQAVCTSLKKEKKTAAPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYP  301
            C K+QAVC S+ +EKKT  PPKL+DLT+LQREANRL+G+TAKQTLDYAQALY K+LLTYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSKYITSDMEGSTKELITGLCAALPFMQGVKLQADLARICDNSKVTDHHAILPTAEFV  361
            RTDS+Y+T DM  +   L++GL   +PF +G++L +++ RI ++ KV+DHHAI+PTAEFV
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  KTGFSSLAESEKKLMTlvcakllcavaaPYEYEAVTAVFTCGGYTFTAKGRTTLCEGWRE  421
            K GF++LAESEKKL++L+C KLLCAVA+P  YEAVTA FTC+G  FTAKG+T L  GW+E
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  IERLSRAA-SGEQDEDAEPEAVLPPLAEGQTFDNPAAEISERYTQPPKAFTEDTLLSAME  480
            IER  R++   + DEDAE+   LP L EGQTF + AA ++E++T PPK++TEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  481  SAGKEDTPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLVAILPDSLT  540
             AG ED PEDAERKGLGT ATRA+I+EKL+  GF +RKGK+LIPTKDG NL  +LP++LT
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEALT  543

Query  541  SPQLTAEWETRLTGIAKGSDSPADFMRGIEEMTAGLVKTYSAISEDKAKLFTPQREAIGT  600
            SPQLTAEWE RLT IAKG   P +FM GIE  +  LV+TYS ISE+K KLF ++R +IGT
Sbjct  544  SPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIGT  603

Query  601  CPRCGAAVYEGKKNFYCSDRACSFVMWKNDRFFEQRKKAFTKAIAAALLKDGKVKIKGMY  660
            CPRCG AVYEGKKN+YC++RAC FVMWKNDRFFE+RKKAFT  IAAALLK GKVK+KG+Y
Sbjct  604  CPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGLY  663

Query  661  STKTGKTFDGVVLLADTGGKYVNFRVEQ  688
            S KTGKT+DG VLLADTGGKYVN+R+E+
Sbjct  664  SVKTGKTYDGTVLLADTGGKYVNYRIEH  691

4) RBR_01000 in NC_021013


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  801 bits (3032),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 464/688 (68%), Positives = 573/688 (84%), Gaps = 1/688 (0%)

Query  2    KLVIAEKPSVGAAIAAVMGANEKRSGYFEGGGYLVSWCIGHLISLADAATYNEQFRKWKY  61
            KLVIAEKPSV+ +IA+V+GA EK+ GY+EG GYLVSWCIGHL+S+ADA+ Y+E+F+KW+Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPIVPQEWQFIVASGKEQQFSILKDLMHRSDVTEIINACDSGREGELIFRFVYEQANC  121
            +DLPI+P+ WQ+IV+ +K QQF +L  LM+R+DVT ++ A D+GREGELIFRFVY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPFSRLWISSMEASAIREGFSNLKDGRGYDNLYQSALCRAKADWLIGINATRLFSILYH  181
            +KPF RLWISSME SAI++GF++LK G +YD LYQSALCRAKADWLIGINATRLFS+LYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  KTLNVGRVQTPTLAMLVNRDYAISSFKKEKYHVVRLDVGGVAALSERQDDEAAARQMKAA  241
            K L VGRVQTPTL MLV+RD  I+ FKKEKYH+V++  GG  A+S R  D A A  +KAA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CEKSQAVCTSLKKEKKTAAPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYP  301
            C K+QAVC S+ +EKKT  PPKL+DLT+LQREANRL+G+TAKQTLDYAQALY K+LLTYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSKYITSDMEGSTKELITGLCAALPFMQGVKLQADLARICDNSKVTDHHAILPTAEFV  361
            RTDS+Y+T DM  +   L++GL   +PF +G++L +++ RI ++ KV+DHHAI+PTAEFV
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  KTGFSSLAESEKKLMTlvcakllcavaaPYEYEAVTAVFTCGGYTFTAKGRTTLCEGWRE  421
            K GF++LAESEKKL++L+C KLLCAVA+P  YEAVTA FTC+G  FTAKG+T L  GW+E
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  IERLSRAA-SGEQDEDAEPEAVLPPLAEGQTFDNPAAEISERYTQPPKAFTEDTLLSAME  480
            IER  R++   + DEDAE+   LP L EGQTF + AA ++E++T PPK++TEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  481  SAGKEDTPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLVAILPDSLT  540
             AG ED PEDAERKGLGT ATRA+I+EKL+  GF +RKGK+LIPTKDG NL  +LP++LT
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEALT  543

Query  541  SPQLTAEWETRLTGIAKGSDSPADFMRGIEEMTAGLVKTYSAISEDKAKLFTPQREAIGT  600
            SPQLTAEWE RLT IAKG   P +FM GIE  +  LV+TYS ISE+K KLF ++R +IGT
Sbjct  544  SPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIGT  603

Query  601  CPRCGAAVYEGKKNFYCSDRACSFVMWKNDRFFEQRKKAFTKAIAAALLKDGKVKIKGMY  660
            CPRCG AVYEGKKN+YC++RAC FVMWKNDRFFE+RKKAFT  IAAALLK GKVK+KG+Y
Sbjct  604  CPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGLY  663

Query  661  STKTGKTFDGVVLLADTGGKYVNFRVEQ  688
            S KTGKT+DG VLLADTGGKYVN+R+E+
Sbjct  664  SVKTGKTYDGTVLLADTGGKYVNYRIEH  691

5) CLS_29900 in NC_021047


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  794 bits (3007),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 455/688 (67%), Positives = 575/688 (84%), Gaps = 1/688 (0%)

Query  2    KLVIAEKPSVGAAIAAVLGANEKRSGYFEGSGYLVSWCIGHLISLADAATYNEQYRKWKY  61
            KLVIAEKPSV+ +IA+V+GA EK+ GY+EG+GYLVSWCIGHL+S+ADA+ Y+E+++KW+Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPIVPQDWQFTVASGKEQQFSVLKDLMHRSDVSEIVNACDSGREGELIFRFVYEQANC  121
            +DLPI+P+ WQ+ V+ +K QQF VL  LM+R+DV+ +V A D+GREGELIFRFVY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPFSRLWISSMEESAIREGFSNLKDGRSYDDLYQSALCRAKADWLVGINATRLFSILYH  181
            +KPF RLWISSME+SAI++GF++LK G  YD LYQSALCRAKADWL+GINATRLFS+LYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  KTLNVGRVQTPTLTMLVNRDYAISSFKKEKYHVVRLNAGGVSALSERLNDEAAAQQMKAA  241
            K L VGRVQTPTL MLV+RD  I+ FKKEKYH+V++ AGG  A+S R++D A A+ +KAA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CEKSQAVCTSLKKEKKTVSPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYP  301
            C K+QAVC S+ +EKKT  PPKL+DLT+LQREANRL+G+TAKQTLDYAQALY K+LLTYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSKYITSDMQDSTKELITGLCSLLPFMRDVKLQADLTRVCDNSKVTDHHAILPTAEFL  361
            RTDS+Y+T DM  +   L++GL  L+PF ++++L +++ R+ ++ KV+DHHAI+PTAEF+
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  KAGFSSLADSETKLMTLVcakllcaaaaPYEYEAVTAAISCGGYTFTAKGKTTLCEGWCE  421
            K GF++LA+SE KL++L+C KLLCA A+P  YEAVTA+++C+G  FTAKGKT L  GW E
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  IEKLSRAA-SEEQDEDAEPETVLPPLAEGQTFDNPAAEISERYTQPPKAYTEDTLLSAME  480
            IE+  R++   + DEDAE+   LP L EGQTF + AA ++E++T PPK+YTEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  481  NAGKEETPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLAAILPEVLT  540
             AG E+ PEDAERKGLGT ATRA+I+EKL+  GF +RKGK+LIPTKDG NLA +LPE LT
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEALT  543

Query  541  SPQLTAEWETRLTGIAKGSDSPDDFMRSIEEMTAGLVKTYSAISEDKAKLFTPQREAIGT  600
            SPQLTAEWE RLT IAKG   PD+FM +IE  +  LV+TYS ISE+K KLF ++R +IGT
Sbjct  544  SPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIGT  603

Query  601  CPRCGAAVYEGKKNYYCSDRACSFVMWKNDLFFQQRKKTFTKAIAAALLKDRKVKIKGMY  660
            CPRCG AVYEGKKNYYC++RAC FVMWKND FF++RKK+FT  IAAALLK  KVK+KG+Y
Sbjct  604  CPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGLY  663

Query  661  STKTGKTFDGVVLLADTGGKYVNFRVEQ  688
            S KTGKT+DG VLLADTGGKYVN+R+E+
Sbjct  664  SVKTGKTYDGTVLLADTGGKYVNYRIEH  691

6) topB in NC_009089


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  788 bits (2984),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 455/689 (67%), Positives = 570/689 (83%), Gaps = 3/689 (0%)

Query  3    LVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNYD  62
            LVIAEKPSVA++IA+V+G  EK DG+L G+GY+VSWC+GHLV++A+A+ Y+E++KKW Y+
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  63   SLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEMAGCK  122
             LPILP+ W+Y V+ DK +QF  L  LM+R+DV+ +V A DAGREGELIFRFVY+MAGC+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  123  KPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATRLFSVLYNH  182
            KP  RLWISSMEDSAIK+GF++LK G +YD+L+ SALCRAKADWLIGINATRLFSVLY+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  183  TLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAASERISNKAEADTLKTTC  242
             L VGRVQTPTLKMLVDRDA IT FKKEKY  V+++ +GA+A S R+S+ AEA+T+K++C
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  243  EASKAVCTSLLKEKKTAAPPKLFDLTSLQREANCLFGYTAKQTLDLAQALYEKRLLTYPR  302
              ++AVC S+ +EKKT  PPKL+DLT+LQREAN LFGYTAKQTLD AQALY K+LLTYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  303  TDSSYLTDDMGDTAAGIIKLLCGKFPFMAGKDFTPELAKVLNSKKVSDHHAIIPTMELAK  362
            TDS YLTDDM  +  +++  L    PF  G +++P++ ++LNSKKVSDHHAIIPT E+ K
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVK  364

Query  363  TDLAALPESERNILTIAGARLIMATAAPHTFEAVTAVFECAGQSFTARGKTVLSDGWKEI  422
             ++++L+ESE+++L++   +L+ A A+PH +EAVTA F CAGQ FTA+GKTVLS GWKEI
Sbjct  365  QGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEI  424

Query  423  DRKYRAILKSKPETDDADSDTEKTLPPFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSA  482
            +R++R+ LK+ +   D D+++ + LP + EGQ F + AA VTEH TTPPKP  E +LLSA
Sbjct  425  ERRFRSSLKTDA---DEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSA  481

Query  483  MERAGSEDTDPDAERKGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDT  542
            MERAG+ED   DAERKGLGTPATRAA++EKLV+ GFV+RKGKQL+PTKDGINL  VLP++
Sbjct  482  MERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  543  LTSPQLTAEWENNLTQIAKGKADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPEL  602
            LTSPQLTAEWEN LT+IAKG+ADP  FM GIE  ARELV+TY+ +SE  +  F+ E+  +
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPI  601

Query  603  GKCPRCGSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKVTFTPKIAAALLKSGKVNVKK  662
            G CPRCG +VYEGKKNYYC+N+ C F MWKNDRFFEERK +FTPKIAAALLK+GKV+VK 
Sbjct  602  GTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKG  661

Query  663  LYSPKTGKTYDGTIALADTGEKYVNYRIE  691
            LYS KTGKTYDGT+ LADTG KYVNYRIE
Sbjct  662  LYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

7) CK5_22580 in NC_021022


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  773 bits (2927),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 453/688 (66%), Positives = 562/688 (82%), Gaps = 2/688 (0%)

Query  2    KLVICEKPSvgaavaaalgvREKKDGYIEGNGYVISWCIGHLVGLAEAAAYGEQYRKWSY  61
            KLVI EKPSV+ ++A+ +G  EK DGY+EGNGY++SWCIGHLV++A+A+ Y+E+++KW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DSLPILPQEWQYTVAADKGKQFKILKDLMQRSDVSEVVNACDAGREGELIFRFVYHQAGC  121
            + LPILP+ WQY V+ DK +QF +L  LMQR+DV+ +V A DAGREGELIFRFVY+ AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPFTRLWISSMETDAIKSGFDNLKDGRRYDALYHSALCRAKADWLIGINATRLFSCLYG  181
            +KPF RLWISSME  AIK GF +LK G  YD+LY+SALCRAKADWLIGINATRLFS LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  KTLNVGRVQTPTLKMLVDRDAAIMNFKKEKYYHVRLMLPGAEAASAKICAADEAGKLKAA  241
            K L VGRVQTPTLKMLVDRDA I +FKKEKY  V++   GA+A S+++  A EA  +KAA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CEASAAVCTSLTRENKTAIPPKLFDLTSLQREANRIYGYTAKQTFDLAQTLYEKKLLTYP  301
            C  + AVC S+TRE+KT  PPKL+DLT+LQREANR++GYTAKQT+D AQ+LY KKLLTYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSNYLTDDMGDTAASIVSLLCGKLPFMASAAYEQSISRVLNSKKVSDHHAIIPTMEIA  361
            RTDS+YLTDDM  +  S+VS L   +PF  +      + R+LNSKKVSDHHAIIPT E+ 
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  KTDLTTLPESERNILILTGARLLMATAEPHVYEAVTAVFSCADHEFTARGKTVIAAGWKN  421
            K ++ TL+ESE+++L L   +LL A A PH+YEAVTA F+CA++EFTA+GKTV+++GWK+
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  IERLYRATLKKKPDSDDENELVLDVPDFTEGQTFENPAAKVTEHETTPPKPHNEASLLSA  481
            IER +R++L  K D+D++ E V ++P++ EGQTF + AA VTEH TTPPKP  E +LLSA
Sbjct  424  IERRFRSSL--KTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSA  481

Query  482  MERAGNEDTDPDAERRGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGTSLVCVLPDS  541
            MERAG ED   DAER+GLGTPATRAA++EKLV+ GFV+RKGKQL+PTKDG +L  VLP++
Sbjct  482  MERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  542  LTSPQLTAAWENNLTQIAKGNADPAAFMQGIEAMAQELVKTYASVLGEKQELFKTEKTEL  601
            LTSPQLTA WEN LT+IAKG+ADP  FM+GIE+ A+ELV+TY+ +  EKQ LF++E+  +
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPI  601

Query  602  GKCPRCKSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKTVFTPKIAAALLKSGKAKVKK  661
            G CPRC  +VYEGKKNYYC+N+ C F MWKNDRFFEERK  FTPKIAAALLK+GK KVK 
Sbjct  602  GTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKG  661

Query  662  LYSVKTGKTYDGTVLLADTGGKYVNYKV  689
            LYSVKTGKTYDGTVLLADTGGKYVNY++
Sbjct  662  LYSVKTGKTYDGTVLLADTGGKYVNYRI  689

8) FPR_01100 in NC_021020


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  724 bits (2738),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 430/573 (76%), Positives = 500/573 (88%), Gaps = 18/573 (3%)

Query  1    MEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATRLFSVLYHKTLTVGRVQTP  60
            MED+AI++GFA+L+P++DYD+LYQSALCRAKADWL+GINATRLFSVLYHK LTVGRVQTP
Sbjct  135  MEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHKNLTVGRVQTP  194

Query  61   TLKMLVDRDAKILRFQKEKYYTVGIQSGSLKAGSGRIADAETANSLKEKCTGTTTVCTSV  120
            TLKMLVDRDAKI  F+KEKY  V I +G+  A S+R++DA  AN++K  C+ + +VC SV
Sbjct  195  TLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAACAKAQAVCVSV  254

Query  121  KREKKTEQPPKLYDLTTLQREVNRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDM  180
             REKKTEQPPKLYDLTTLQRE NRLFG+TAKQTLDYAQ LY KKLLTYPRTDSQYLT+DM
Sbjct  255  TREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPRTDSQYLTDDM  314

Query  181  GQTVRHLVSDLLGLLPFAQRLVLTPDVSRVLNSNKVSDHHAIIPTAEFAKQGFTGLAESE  240
              +V  LVS+L  L+PFA+ L L+P+  R+LNS+KVSDHHAIIPTAEF KQGF  LAESE
Sbjct  315  LPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVKQGFGTLAESE  374

Query  241  CKLMNLVCSKLLCAVAIPHEYETVTAVFSCAGNEFTAKGKTVLVPGWKEIDQRFRSTLKA  300
             KL++L+C KLLCAVA PH YE+VTA F+CAG+EFTAKGKTVL PGWKEI++RFRS+LK+
Sbjct  375  KKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEIERRFRSSLKT  434

Query  301  DTEE--EVLNTLPELAEGQSFS-VTANVSEHFTSPPKAYTEDTLLSAMEWAGAEDMPEDK  357
            D++E  E +  LPEL EGQ+F+ V+A+V+EHFT+PPK+YTEDTLLSAME+AGAEDMPED 
Sbjct  435  DADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAMERAGAEDMPED-  493

Query  358  VNCSAGAREGGLGQAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLP  417
                          AERKGLGTPATRAAILEKLVQ+GFVQRKGKQL+PTKDGINLAVVLP
Sbjct  494  --------------AERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLP  539

Query  418  ESLTSPALTAEWENRLTEIAKGNADPDEFMAEIEAQVHQLVKTYSCISADKQNLFQSERV  477
            E+LTSP LTAEWENRLTEIAKG+ADPDEFM  IE+Q ++LV+TYSCIS +KQ+LFQ+ERV
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  478  IIGKCPRCGENVYDGKKNFYCGNRGCQFVMWKNDRFFEQRKKAFTPKIAAALLKNGKAKV  537
             IG CPRCGE VY+GKKN+YCGNR+CQFVMWKNDRFFE+RKKAFTPKIAAALLK GK KV
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  538  KGLYSEKTGKTYDATVLLADTGGKYVNYRVERK  570
            KGLYS KTGKTYD+TVLLADTGGKYVNYR+E++
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIEHR  692

9) CK5_29340 in NC_021022


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  691 bits (2614),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 395/692 (58%), Positives = 520/692 (76%), Gaps = 5/692 (0%)

Query  2    KLVIAEKPSVAMSLAAVLGATERKDGYLEGSGYLVSWCVGHLLELAQPEAYKEQYAKWRY  61
            KLVIAEKPSVA S+A+V+GATE+ DGYLEG+GYLVSWC+GHL+ +A++  Y E++ KWRY
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPILPENWKYEVPKDKKTQLALLCRLMKDKRVDSVVCATDAGREGELIFRLVYEYAGC  121
            EDLPILPE W+Y VP DKK Q+ +LC LM+   V ++VCATDAGREGELIFR+VY+ AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPMERLWISSMEDAAIREGFDHLHPGSDYDKLYDAAVCRAGADWLIGINATRLFSVLYG  181
            +KP ERLWISSMED+AI++GF HL PG+DYD LY++A+CRA ADWLIGINATRLFSVLY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  VTLNVGRVMSPTLALLVQRESDIESFISKPFYVPEITCGGFTASGEKMTERSEAEKIRMD  241
              L VGRV +PTL +LV+R++ I  F    + + +IT GG  A + + ++ +EA+ ++  
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CDHNSAFVRSVEKQVKTIQPPRLYDLTTLQRECNRIYGYTAQQTLDYVQSLYEKKLATYP  301
            C    A   SV ++ KT QPP+LYDLTTLQRE NR++GYTA+QTLDY Q+LY KKL TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSQYLTKDMQATAASLILWLRDNMTFGKGYAGEPDIDRVTDDSKVTDHHAIIPTVEIA  361
            RTDSQYLT DM ++  SL+  L++ + F+KG    P++DR+ +  KV+DHHAIIPT E+ 
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  RTDLSELPSGERDVLTLLAVRLLCATTQVHRFEAVTAILDCQGYTFTAKGKTILQSGWKE  421
            + +++ L+ +E+ +L+L+  +LLCA +  H +EAVTA + C G  FTAKGKT+L +GWKE
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  VERIHRMSIRQSETERRENEDAALPVLKEGQTFETVSASLREGKTSPPKHYTEDTLLSAM  481
            +ER  R S++ ++++   +    LP L EGQTF  V+AS+ E  T+PPK YTEDTLLSAM
Sbjct  424  IERRFRSSLK-TDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  482  ETAGAEDMPEDAERKGLGTPATRAATLEKLVSAGFVQRKKKQLIPTEKGKNLIAVLPDNI  541
            E AGAEDMPEDAERKGLGTPATRAA LEKLV  GFVQRK KQLIPT  G NL  VLP+ +
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  542  KSPILTAEWESMLKQVEHGELSATSFMDQIADMSRTLVKEHTTPEERFADLFPSSKGTAH  601
             SP LTAEWE+ L ++  G+  +  FMD I   +R LV+  +   E    LF + +    
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV---  599

Query  602  EAVGVCPRCGAPVFEGKKGFFCGNRECSFALWKDNRFFsskkksitksVAAALLKEGRIS  661
             ++G CPRCG +V+EGKK ++CGNR C F +WK++RFF  +KK++T  +AAALLK G++ 
Sbjct  600  -PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVK  658

Query  662  MSGLYSEKTGRTYDAEVILDDTGGKYVNFKLE  693
            + GLYS KTG+TYD+ V+L DTGGKYVN+++E
Sbjct  659  VKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

10) RBR_21180 in NC_021013


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  690 bits (2611),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 400/601 (67%), Positives = 499/601 (84%), Gaps = 2/601 (0%)

Query  1    MHRADVSEVVNACDAGREGELIFRFVYEVAGCKKPMRRLWISSMEDGAIKAGFASLKDGR  60
            M+R+DV+ +V A DAGREGELIFRFVY++AGC+KP  RLWISSMED+AIK GFA LK G 
Sbjct  92   MQRPDVTGLVCATDAGREGELIFRFVYQMAGCQKPFERLWISSMEDSAIKDGFAHLKPGG  151

Query  61   DYGALFASALCRAKADWLIGINATRLFSCLYGKTLNVGRVQTPTLKMLTDRDAAISHFQK  120
            DY++L+ SALCRAKADWLIGINATRLFS LY K L VGRVQTPTLKML DRDA I++F+K
Sbjct  152  DYDPLYQSALCRAKADWLIGINATRLFSVLYHKNLTVGRVQTPTLKMLVDRDAKITDFKK  211

Query  121  EKYYHVRLDLSGADAASERISDKAEADALKGACEAGKAVCVSLTREKKTAAPPKLFDLTS  180
            EKY  V++  +GADA S R+SD AEA+++K+AC  ++AVCVS+TREKKT  PPKL+DLT+
Sbjct  212  EKYHIVHITAGGADAVSSRFSDAAEANTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTT  271

Query  181  LQRETNRIFGYTAKQTLDLAQSLYEKRLLTYPRTDSSFLTDDMGGTAADIIALLCEKLPF  240
            LQRE+NR+FGYTAKQTLD AQ+LY K+LLTYPRTDS +LTDDM  +   +++ L E +PF
Sbjct  272  LQREANRLFGYTAKQTLDYAQALYLKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF  331

Query  241  MAGADFTPEIAKVLDSKKVSDHHAIIPTMELAKADPDALPESEKNILTLAGARLLFATAE  300
              G +++P++ ++L+SKKVSDHHAIIPT E+ K + ++L+ESEK++L+L   +LL A A 
Sbjct  332  AKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAG  391

Query  301  PHIYEAVTAVFSCAGTDFTARGKTVLAEGWKELERRYRATLKDKPEAEDGENEGVTLPEL  360
            PHIYEAVTA F+CAG +FTA+GKTVL+ GWKE+ERR+R++L  K +A+++ +    LPEL
Sbjct  392  PHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEIERRFRSSL--KTDADEDAEAVRELPEL  449

Query  361  SEGQNFPNPAAKVTEHTTTPPKPHSEASLLSAMERAGNGDTDPDAERRGLGTPATRAAVI  420
             EGQ F++ AA VTEH TTPPKP +E +LLSAMERAG  D   DAER+GLGTPATRAA++
Sbjct  450  CEGQTFADVAASVTEHFTTPPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAIL  509

Query  421  EKLVKGGFAERKGKQLIPTQNGAALISVLPDMLTSPQLTAEWENNLTQIAKGAADPGEFL  480
            EKLV+ GF +RKGKQLIPT++G  L  VLP+ LTSPQLTAEWEN LT+IAKG ADP+EF+
Sbjct  510  EKLVQMGFVQRKGKQLIPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFM  569

Query  481  SGIEAMARELVQTHAAALDGKKDLFREEKPSVGKCPRCGSPVHEGKKNYYCSNKECAFVM  540
             GIE+ ARELVQT +   + K+ LF+ E+ ++G CPRCG +V EGKKNYYC+N+ C FVM
Sbjct  570  DGIETQARELVQTYSCISEEKQKLFQAERVPIGTCPRCGEAVYEGKKNYYCGNRACQFVM  629

Query  541  WKNDRFFEERKTAFSAKIAAALLKSGKVNVKKLYSPKTGKTYDGTIVLADTGGKYVNYRI  600
            WKNDRFFEERK AF++KIAAALLK+GKV+VK LYS KTGKTYDGT++LADTGGKYVNYRI
Sbjct  630  WKNDRFFEERKKAFTPKIAAALLKTGKVKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRI  689

Query  601  E  601
            E
Sbjct  690  E  690

11) CLS_04840 in NC_021047


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  667 bits (2520),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 382/691 (56%), Positives = 512/691 (75%), Gaps = 6/691 (0%)

Query  2    RLVIAEKPSVAKSLATVLGAATRKDGYLEGNGWLVSWCLGHLAGLADAATYNPDYAKWRY  61
            +LVIAEKPSVA+S+A V+GA+ + DGYLEGNG LVSWC+GHL ++ADA+ Y+  + KWRY
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPILPETWRFTIAKDKRDQFDVLRTLLRREDVTEVVNACDAGREGELIFRTVYCLAGC  121
            +DLPILPETW++ ++ DK++QFDVL +L++R DVT +V A DAGREGELIFR VY +AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  QKPMKRLWISSMEDSAIREGFAHLRPGADYDGLHQAALCRAKADWLVGINATRLFSVLYH  181
            QKP  RLWISSMEDSAI++GFAHL+PG+DYD L Q+ALCRAKADWL+GINATRLFSVLYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  RTLNIGRVMSPTLALIVQREAEIDAFKPVPFYTVALDLPGFTAASARMDKKADAEQLKNA  241
            + L +GRV +PTL ++V+R+A I  FK   +  V +   G  A S+R    A+A+ +K A
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CQSGTVTVKQVARRDKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQNLYEKKLCTYP  301
            C  +      V+R  K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q LY KKL TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSRYLTSDMAEGLPVLVNLVANAMPFRKGIAISCDAAAVINDKKVTDHHAVIPTRNIR  361
            RTDS+YLT DM  ++  LV+ + + +PF KG+ +S +   ++N KKV+DHHA+IPT ++ 
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  EADLSALPVGERAILELVALRLLCAVAHPYIYDETSVTVECAGAEFTAKGRTVKQPGWRA  421
              ++++L+ +E+ +L L+  +LLCAVA P IY+  + T  CAG EFTAKG+TV  PGW+ 
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  LDAAYRASMKNAEPDKETEDKALPELAEGQELPVAGAAVKEGKTTPPKHFTEDTLLSAME  481
            ++  +R+S+K    +     + LPEL EGQ ++  +A+V E  TTPPK +TEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  482  TAGAKDMPEDAERKGLGTPATRAGILEKLVSTGFLERKKSKKTVQLLPSHDAISLITVLP  541
             AGA DMPEDAERKGLGTPATRA+ILEKLV  GF++RK      QL+P+ D+I+L  VLP
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAVVLP  539

Query  542  EQLQSPLLTAEWEYRLGEIERGELAPEDFMAEITAMLKELVGTYQVIKGS-EYLFAPPRE  600
            E L SP LTAEWE RL EI +G+  P++FM  I +  +ELV TY  I    + LF + R 
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  601  VVGKCPRCGGEIAEMQKGFFCQDKSCKFAIWKNSKWWAAKRKQPTKAIVAALLKDGRARV  660
             +G CPRCG  + E +K ++C +++C+F +WKN +    ++K  T  I AALLK G+ +V
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  661  TGLYSEKSGKTYDATVVLEDT-GQYVNFKLE  690
             GLYS K+GKTYD+TV+L DT G+YVN+++E
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

12) CCU_07970 in NC_021018


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  658 bits (2486),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 366/678 (54%), Positives = 519/678 (77%), Gaps = 10/678 (1%)

Query  2    QLVIAEKPSVAKSIADVLGALDRQDGYFEGGGYLVSWCVGHLIELAEPESYGEQWKKWTY  61
            +LVIAEKPSVA+SIA+V+GA +++DGY+EG GYLVSWC+GHL+ +A++  Y+E+ KKW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ESLPVNPEHWQYEIKEDTKEQYDVLYGLLHDSRVDEVVCATDAGREGELIFRLVYNMASC  121
            E LP+ PE WQY + +D K+Q+DVL +L++ + V  +VCATDAGREGELIFR+VY+MA+C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPMKRLWISSMEESAIREGVENLKPGSDYDHLYHSALCRQEADWLVGINGTRLFTVLYG  181
            +KP  RLWISSME+SAI++G  +LKPG+DYD LY+SALCR  ADWL+GIN+TRLF+VLY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  GKVLKVGRVQTPTLAMLVEREAKIMNFKKEQYFMAHILCGGVDAVTERIDNKTEAENVAG  241
             K L VGRVQTPTL MLV+R+AKI +FKKE+Y + HI  GG DAV+ R+ + +EA+ V +
Sbjct  184  -KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  242  ACRNGQALVTSVEKEEKTVSPPKLYDLTTLQRDANRLFGFTAKQTLEYTQSLYEKKMCTY  301
            AC ++QA+  SV +E KT  PPKLYDLTTLQR+ANRLFG+TAKQTL+Y+Q+LY KK+ TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  302  PRTDSQYLSDDMEQTAGNVIEAIFSSILFEENRMFNPDIKRVLNSKKVTDHHAIIPTMEI  361
            PRTDSQYL+DDM  +  +++ ++   + F     ++P++ R+LNSKKV+DHHAIIPT E+
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  362  AKADLAALPETERKILSLVANRLLCATGEKHLYETVKAELSCGGYTFTTSGKSVLKNGWK  421
             K ++++L+E+E+K+LSL+  +LLCA +  H+YE+V A ++C+G  FT+ GK+VL  GWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  422  DFEDAFKRSFKATEEKEQED-KKLPELSEGQTFDGVQTKISEHYTTPPKHFTEDSLLSAM  480
            ++E  F+ S+K+  + + E  + LPEL EGQTF +V + ++EH+TTPPK +TED+LLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  481  ERAGNEDMSDDVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDVV  540
            ERAG EDM++D ERKGLGTPATRA I+EKLV+ GFV+R  KQ++PT DG++L  VLP+ +
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  541  KSSKLTADWENALTLVAKGEMEREDFMADIETMESDLIHTYHEVSDEQKKMFAQEQKVLG  600
             S++LTA+WEN LT +AKG+ + ++FM +IET   +L++TY  +S+E++K+F  E+  +G
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIG  602

Query  601  KCPNCGGEVVKGKYGAFCKNK-CGMNV---SRIMGV---ALSDEQVESLLAGKKTLLKGI  653
             CP CG  V  GK   +C N+ C   +    R+      A++     +LL   K  +KG+
Sbjct  603  TCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGL  662

Query  654  -TSKAGKKYDAYIIPSGT  670
             + K+GK YD+ ++ ++T
Sbjct  663  YSVKTGKTYDGTVLLADT  680

13) RHOM_15375 in NC_015977


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  632 bits (2390),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 356/660 (54%), Positives = 490/660 (75%), Gaps = 8/660 (1%)

Query  2    QLVVTEKPSVAQAISHVIGAKERKDGYMEGNGFLVSWCVGHLVELAQPEMYSEAWKKWSY  61
            +LV++EKPSVA++I+ VIGA E+ DGY+EGNG+LVSWC+GHLV +A++  Y E  KKW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ESLPMIPEQWQHEVKKETATQYKILKNLMHDTRVESVVCATDAGREGELIFRLVYEQAGC  121
            E LP++PE WQ  V  +   Q+ +L +LM+   V ++VCATDAGREGELIFR+VY+ AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  RKPMKRLWISSMEESAIRDGFENLKPGSDYDSLYQSALCRQQADWLVGLNGTRLFTVLYG  181
            +KP  RLWISSME+SAI+DGF +LKPG+DYD+LYQSALCR +ADWL+G+N+TRLF+VLY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  GKVLKVGRVQTPTLAMLVDREVKIMNFEKEQYYMAHILMDGIDAMTERIDDKARAESIAA  241
             K L VGRVQTPTL MLVDR+ KI +F KE+Y + HI  +G DA++ R+ D A A+++ A
Sbjct  184  -KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  242  ACESQSGVVRSVIKENKSVAPPKLYDLTTLQRDANRIFGFTAKQTLEYTQSLYEKKLVTY  301
            AC    +V  SV +E+K+  PPKLYDLTTLQR+ANR+FG+TAKQTL+Y+Q+LY KKL+TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  302  PRTDSQYLSDDMEETAKAVIGAVYQAILFEEQTGAEPDIKRVLNSKKVTDHHAIIPTIEI  361
            PRTDSQYL+DDM  +  ++++++ + + F       P++ R+LNSKKV+DHHAIIPT E+
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  362  TKTDLSAVPEGEMKILSLVANRLLCATGKKQLYETVKAEFSCGGYSFHVSGKTVLQNGWK  421
             K ++++++E+E K+LSL+  +LLCA +  ++YE+V A F+C+G  F   GKTVL  GWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  422  EFEAALKRTYRVektdedkeekkLPELSEGMTFPVIQTKVTEHFTQPPKHFTEDSLLSAM  481
            E+E  ++ + + +  ++    + LPEL EG TF+ + + VTEHFT PPK +TED+LLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  482  ERAGAEDMGDEVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDMV  541
            ERAGAEDM ++ ERKGLGTPATRA I+EKLV+ GFV+R  KQ++PT DG++L  VLP+ +
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  542  KSPKLTADWENTLTLVEKGEYTMQEFMDGIEDMVRELVQTYHSISDDQKSLFGTMQEVLG  601
             SP+LTA+WEN LT + KG+   +EFMDGIE   RELVQTY  IS++++ LF + +  +G
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIG  602

Query  602  KCPKCGSDVVKGKFGAYCKQK-CGMNV---GRAMGA---TFSDTQMKSLLEGKKTLVRGL  654
             CP+CG  V  GK   YC ++ C   +   +R       +F+     +LL   K  V+GL
Sbjct  603  TCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGL  662

14) topB-2 in NC_004668


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  630 bits (2382),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 356/694 (52%), Positives = 511/694 (74%), Gaps = 8/694 (1%)

Query  2    QLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNY  61
            +LVIAEKPSV+ +++ V+GA  + DGY+EG G LVSWCIGHLV +A A+ YD R+ KW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGC  121
             DLPILP  WQ+ V  D K+QF+VL +L++R+DVT+L+CATDAGREGELIFR+ Y++ GC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  TKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQ  181
             KP  RLWISSME++AI+ GF +L  G +YD LY +ALCRAKADWLIGIN+TRLF+ LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  GKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRT  241
             K+L VGRVQTPTL +L +R+A I++F+KEK+  V++   G  A S RF+  ++A  +++
Sbjct  184  -KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  242  GCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATY  301
            +C    A   +V++  KTE+PPKLYDLTTLQREANRLF+YTA+QTLDY QALY K+L TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  302  PRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEA  361
            PRTDS+YLT+DM +++ +L  ++   +PFA +L+L+ +  +++++ KV+DHHAI+PT+E 
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  362  AKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWT  421
             K ++++L+ +EK++L L+  +LLCAV+ PH Y   + T+ C+G  F+AKGKT  ++GW 
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  422  AMEQAFHATlkkkpkqpepspplpalt-kGQKLTAGGASIKEGATSPPAHFTEDTLLSAM  480
             +E+ F+++LK  + +   +    +    GQ ++  +AS+ E  T+PP  +TEDTLLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  481  EHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPD  540
            E+A+A + +  ED E+KGLGTPATRA+++EKLV+ GFV+RK KQL+PT  G +L  V+P+
Sbjct  483  ERAGAEDMP--EDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540

Query  541  TLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTV  600
            +L S +LTAEWE+RL  + +G+  P++FM GI +   ELV++Y  ++     L  + R  
Sbjct  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP  600

Query  601  IGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRkaaaallkkGR  660
            IG CPRCG  V EGKK+++C    +  AC+F +WKNDRFF  + K +T K AAALLK G+
Sbjct  601  IGTCPRCGEAVYEGKKNYYC----GNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  661  VAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLE  694
            V + GL+S K G  YD+ V++ DTG K+V +++E
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

15) EUBREC_3570 in NC_012781


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  627 bits (2369),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 374/693 (54%), Positives = 500/693 (73%), Gaps = 16/693 (2%)

Query  2    KLVIAEKPSVAMALASVIGARTRKDGYVEGNGYLVSWCVGHLVGLCDASEYDEKYKKWRY  61
            KLVIAEKPSVA ++A+VIGA  + DGY+EGNGYLVSWC+GHLV++ DA+ YDE++KKWRY
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPIVPECWKHRVLEGTKKQFGILKKLMRDSKVDEVICATDAGREGELIFRLVYEQAGC  121
            EDLPI+PE W+  V ++ K+QF++L  LM+ + V  ++CATDAGREGELIFR+VY+ AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPMKRLWISSMEEQAIKDGFASLKDGSCYDSLYQSALCRAKADWLVGINASRLFSVLYN  181
            +KP  RLWISSME+ AIKDGFA LK G+ YD+LYQSALCRAKADWL+GINA+RLFSVLY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNLKVGRVQTPTLAMIVDRNQKIKEFTKEKYYMAHIKFDEMDAVTEHFQKKEDADRVAAD  241
            +NL VGRVQTPTL M+VDR+ KI +F KEKY + HI  +  DAV+ +F    +A+ V A 
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  C--MERMC-EVEKDDVKEKTVRPPKLYDLTTLQREANRMFGYTAQQTLDAVQEMYEQKLV  298
            C   + +C  V ++    KT +PPKLYDLTTLQREANR+FGYTA+QTLD  Q +Y +KL+
Sbjct  244  CAKAQAVCVSVTREK---KTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  299  TYPRTDSQYLTDEMGESTETLIQMLLGKMPYAEGLEYHPDVSKVLNSKKVSDHHAIIPTM  358
            TYPRTDSQYLTD+M  + E+L+  L   +P+A GL+  P+  ++LNSKKVSDHHAIIPT 
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  359  EVAKADIGELKERNRKILYLISARVLTATADPYIYESHKCQITCNYHTFYLTAKKTKQEG  418
            E  K ++G L E ++K+L LI  ++L A A+P IYE+    +TC  + F   +K     G
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  419  FKAIENKLKQFFGVKIEKEEPELDIW------AGKHYGPCDSLVSEHFTQPPKQYTEDTL  472
             K IE +++   ++K + +E    ++       G+ ++   + V+EHFT PPK YTEDTL
Sbjct  421  WKEIERRFRS--SLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTL  478

Query  473  LSAMERAGNEELTEDTEKKGLGTPATRAAIIEKLIQSGFVKREKKNLVPTDDGNVLITVL  532
            LSAMERAG E++ ED+E+KGLGTPATRAAI+EKL+Q GFV+R  K+L+PT DG  L  VL
Sbjct  479  LSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVL  538

Query  533  PDEIKSPKMTAEWEMALNHIAQNTETADEFLNGITELMQELVARYQGISEEKKNQFQGKA  592
            P+ + SP++TAEWE  L +IA+    +DEF++GI    +ELV  Y  ISEEK++ FQ+  
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAER  598

Query  593  KGEVIGKCPRCGADVQEGKVNFYCSDRNCTFTLWKNDKFLASQGKKMDKTAAKKFLSKGK  652
                IG CPRCG  V EGK N+YC++R C F +WKND+F+  + K      A  +L  GK
Sbjct  599  VP--IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  653  IHYKDLVSRKTGRQYEATVEMVDPGEGNVQFNL  685
            +  K+L S KTG+ Y++TV + D G   V++ +
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRI  689

16) EUR_07600 in NC_021010


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  616 bits (2329),  Expect = 1e-177, Method: Compositional matrix adjust.
 Identities = 381/692 (56%), Positives = 512/692 (74%), Gaps = 6/692 (0%)

Query  4    HKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWR  63
             KLVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD ++ KWR
Sbjct  3    YKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWR  62

Query  64   YDDLPILPEHWQMVVGkdkkkqfdilkklMNAPDVTEVVNACDAGREGEMIFRSVYKLAG  123
            Y+DLPILPE WQ +V  DKK+QFD+L  LM+ PDVT +V A DAGREGE+IFR VY++AG
Sbjct  63   YEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAG  122

Query  124  CKKPMKRLWISSMEDSAIREGFANLRPSADYDGLRDAALCRAKADWLVGINATRLFSVLY  183
            C+KP  RLWISSMEDSAI++GFA+L+P++DYD L ++ALCRAKADWL+GINATRLFSVLY
Sbjct  123  CQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLY  182

Query  184  HRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERMANKAAAEQLKE  243
            H+ L +GRV +PTL ++V+R+A I  FK   +  V +   G    + R ++ A A+ +K 
Sbjct  183  HKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  244  ACQGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTY  303
            AC  A+     V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  304  PRTDSRYLTGDMADSLPVLVNLVASAMPFRKGIAITCDPHTVINDKKVTDHHAVIPTRNL  363
            PRTDS+YLT+DM  ++  LV+ +   +PF KG+ ++ + + ++N KKV+DHHA+IPT ++
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  364  KDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWK  423
               ++++L+ +EK +L L+  +L+CAVA PHIY       +CAG EFT+KGKTV  PGWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  424  ALEDAYRAKMKNAEPKKEGAEKALPELTEGQTLSVAAAIVKEGKSSPPQHFTEDTLLSAM  483
             +E  +R+ +K        A + LPEL EGQT++  AA V E  ++PP+ +TEDTLLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  484  ETAGKENMPEDAERKGLGTPATRAGILEKLVSAGFLERKKNRKTVQLLPSHDAVSLITVL  543
            E AG E+MPEDAERKGLGTPATRA+ILEKLV  GF++RK +    QL+P+ D+++L  VL
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAVVL  538

Query  544  PEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIK-GTEYLFTPPR  602
            PE L SP LTAEWE RL EI +GQ  P+EF+DGI T  ++LV TY  I    + LF + R
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAER  598

Query  603  EVVGKCPRCGGEVAELQKGFFCQNDSCKFAIwknnkwwaakkkQPTKAVVSALLNDGRVR  662
              +G CPRCG  V E +K ++C N +C+F +WKN++    +KK  T  + +ALL+ G+V+
Sbjct  599  VPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVK  658

Query  663  VTGLYSEKTGKTYDATVVLED-DGQYANFKLE  693
            V GLYS KTGKTYD+TV+L D +G+Y N+++E
Sbjct  659  VKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

17) RTO_00720 in NC_021015


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  614 bits (2318),  Expect = 9e-177, Method: Compositional matrix adjust.
 Identities = 382/692 (56%), Positives = 511/692 (74%), Gaps = 6/692 (0%)

Query  4    HKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWR  63
             KLVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD ++ KWR
Sbjct  3    YKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWR  62

Query  64   YDDLPILPEHWQMVVGkdkkkqfdilkklMNAPDVTEVVNACDAGREGELIFRSVYELAG  123
            Y+DLPILPE WQ +V  DKK+QFD+L  LM+ PDVT +V A DAGREGELIFR VY++AG
Sbjct  63   YEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAG  122

Query  124  CKKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLY  183
            C+KP  RLWISSMEDSAI++GFA+L+PG+DYD L ++ALCRAKADWL+GINATRLFSVLY
Sbjct  123  CQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLY  182

Query  184  HRTLNIGRVMSPTLALIVQREAEIDTFQPVPFYTVALELPGLTVSGERMADKAAAKQLKE  243
            H+ L +GRV +PTL ++V+R+A I  F+   +  V +   G    + R +D A A+ +K 
Sbjct  183  HKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  244  TCRGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTY  303
            +C  A+     V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  304  PRTDSRYLTSDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNL  363
            PRTDS+YLT DM  ++  LV+ + + +PF KG+ ++ + + ++N KKV+DHHA+IPT ++
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  364  KDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACAGGEFTAKGKTVKHPGWK  423
               ++++L+ +EK +L L+  +LLCAVA PHIY       +CAG EFTAKGKTV  PGWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  424  ALEDAYRAKMKDAEPKKEGAEKALPELTEGQTLSVAAAIVKEGKSSPPQHFTEDTLLSAM  483
             +E  +R+ +K        A + LPEL EGQT++  AA V E  ++PP+ +TEDTLLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  484  ETAGKENMPEEAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVL  543
            E AG E+MPE+AERKGLGTPATRA+ILEKLV  GF++RK      QL+P+ D+++L  VL
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAVVL  538

Query  544  PEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIK-GTEYLFTPPR  602
            PE L SP LTAEWE RL EI +GQ  P+EF+DGI T  ++LV TY  I    + LF + R
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAER  598

Query  603  EVVGKCPRCGGEVAELQKGFFCQNDSCKFAIwknnkwwdakkkQPTKAVVSALLNDGCVR  662
              +G CPRCG  V E +K ++C N +C+F +WKN++  + +KK  T  + +ALL+ G V+
Sbjct  599  VPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVK  658

Query  663  VTGLYSEKTGKTYDAAVVLED-DGQYANFKLE  693
            V GLYS KTGKTYD++V+L D +G+Y N+++E
Sbjct  659  VKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

18) EUS_14250 in NC_021011


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  612 bits (2313),  Expect = 2e-176, Method: Compositional matrix adjust.
 Identities = 385/694 (56%), Positives = 508/694 (74%), Gaps = 6/694 (0%)

Query  2    MRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAK  61
            M YKLVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD ++ K
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  62   WRYDDLPILPEHWQMVVGkdkkkqfdilkklMNAPDVTEVVNACDAGREGEMIFRSVYEL  121
            WRY+DLPILPE WQ +V  DKK+QFD+L  LM+ PDVT +V A DAGREGE+IFR VY++
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  122  ADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSV  181
            A+CQKP  RLWISSMEDSAI++GFA+L+PG+DYD L ++ALCRAKADWL+GINATRLFSV
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  182  LYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQM  241
            LYH+ L +GRV +PTL ++V+R+A I  FK   +  V +   G    + R SD A A+ +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  242  KEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLC  301
            K AC  A      V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL 
Sbjct  241  KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  302  TYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTR  361
            TYPRTDS+YLT+DM  ++  LV+ + + +PF K + ++ + + ++N KKV+DHHA+IPT 
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  362  NLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPG  421
            ++   ++++L+ +EK +L L+  +LLCAVA PHIY       +CA+ EFTAKGKTV  PG
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  422  WKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLS  481
            WK +E   R+ +K        A + LPEL EGQT++  AA V E  ++PP+ +TEDTLLS
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  482  AMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLIT  541
            AME AG EDMPEDAERKGLGTPATRA+ILEKLV  GF++RK      QL+P+ D+++L  
Sbjct  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAV  536

Query  542  VLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQ-VIKGTEYLFTP  600
            VLPE L SP LTAEWE RL EI  GQ  P+EF+ GI T  ++LV TY  +    + LF +
Sbjct  537  VLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQA  596

Query  601  PREVVGKCPRCGGEVAELQKGFFCQSKECRFAIwknnkwwtakkkQPTKAVVSALLKDGC  660
             R  +G CPRCG  V E +K ++C ++ C+F +WKN++    +KK  T  + +ALLK G 
Sbjct  597  ERVPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  661  VRVTGLYSEKTGKTYDATVVLED-DGQYANFKLE  693
            V+V GLYS KTGKTYD+TV+L D +G+Y N+++E
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

19) FPR_14240 in NC_021020


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  612 bits (2312),  Expect = 2e-176, Method: Compositional matrix adjust.
 Identities = 385/694 (56%), Positives = 508/694 (74%), Gaps = 6/694 (0%)

Query  1    MRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAK  60
            M YKLVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD ++ K
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WRYDDLPILPEHWQMVVGkdkkkqfdilkklMNAPDVTEVVNACDAGREGEMIFRSVYEL  120
            WRY+DLPILPE WQ +V  DKK+QFD+L  LM+ PDVT +V A DAGREGE+IFR VY++
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  ADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSV  180
            A+CQKP  RLWISSMEDSAI++GFA+L+PG+DYD L ++ALCRAKADWL+GINATRLFSV
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  LYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQM  240
            LYH+ L +GRV +PTL ++V+R+A I  FK   +  V +   G    + R SD A A+ +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  241  KEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLC  300
            K AC  A      V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL 
Sbjct  241  KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  301  TYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTR  360
            TYPRTDS+YLT+DM  ++  LV+ + + +PF K + ++ + + ++N KKV+DHHA+IPT 
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  361  NLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPG  420
            ++   ++++L+ +EK +L L+  +LLCAVA PHIY       +CA+ EFTAKGKTV  PG
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  421  WKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLS  480
            WK +E   R+ +K        A + LPEL EGQT++  AA V E  ++PP+ +TEDTLLS
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  481  AMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLIT  540
            AME AG EDMPEDAERKGLGTPATRA+ILEKLV  GF++RK      QL+P+ D+++L  
Sbjct  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAV  536

Query  541  VLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQ-VIKGTEYLFTP  599
            VLPE L SP LTAEWE RL EI  GQ  P+EF+ GI T  ++LV TY  +    + LF +
Sbjct  537  VLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQA  596

Query  600  PREVVGKCPRCGGEVAELQKGFFCQSKECRFAIwknnkwwtakkkQPTKAVVSALLKDGC  659
             R  +G CPRCG  V E +K ++C ++ C+F +WKN++    +KK  T  + +ALLK G 
Sbjct  597  ERVPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  660  VRVTGLYSEKTGKTYDATVVLED-DGQYANFKLE  692
            V+V GLYS KTGKTYD+TV+L D +G+Y N+++E
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

20) Ethha_1903 in NC_014828


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  612 bits (2311),  Expect = 3e-176, Method: Compositional matrix adjust.
 Identities = 380/691 (55%), Positives = 515/691 (75%), Gaps = 21/691 (3%)

Query  2    RFVISEKPSVAQSIAAVIGAKQRGDGFLEGNGYLVSWCLGHLAELASADAYDEKYAKWRR  61
            ++VI+EKPSVA+SIA+VIGA ++ DG+LEGNGYLVSWC+GHL  +A A+ YDE++ KWR 
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPILPENWRFTVSGDKQKQFAILRTLMRRDDVDEVINACDAGREGELIFRTVYDMAGC  121
            EDLPILPE W++ V++DK++QF +L +LM+R DV  ++ A DAGREGELIFR VY+MAGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  SKPMKRLWISSMEDEAIRQGFADLKPGRDYDGLHQSALCRSKADWLVGINATRLFSALYH  181
             KP  RLWISSMED AI++GFA+LKPG DYD L QSALCR+KADWL+GINATRLFS LYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  RTLNVGRVMSPTLALLVQREAEISAFQPEPFYTVSLDCGTFTAIGDKLKTKSEAEAVAAA  241
            + L VGRV +PTL +LV+R+A I+ F+ E +  V +  G   A++ ++   +EA++V AA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CKGKTATVRAVERKEKSEKPPALYDLTTLQRDANRLLGYTAQQTLDYLQSLYEKKLCTYP  301
            C    A   +V R  K+E+PP LYDLTTLQR+ANRL+GYTA+QTLDY Q+LY KKL TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSRFLTNDMKasvpafasvaaaICGTDVPESLNA--GQVCDSAKVSDHHAVVPTSGAG  359
            RTDS++LT+DM ++V ++ S    +       +L++  +++ +S KVSDHHA++PT+   
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  360  KADVSALPAGEREILRLVSRQLLCAVGSPHQYAETAVTLDCTGYGFAAKGKTVLVPGWKS  419
            K + ++L+ +E+ +L L+  +LLCAV++PH Y   + T+ C+G  F+AKGKTVL PGWK 
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  420  C---F----------QEQADKPLPELAEGQDIAVASVSVKEGKTSPPKHYTEDTLLSAME  466
                F          + +A + LPEL EGQ +A  + SV E  T+PPK YTEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  467  TAGAKDMPDDAERKGLGTPATRAAILEKLVTTGFVERKKAKKTVNLIPSQVGVSLVTVLP  526
             AGA DMP+DAERKGLGTPATRAAILEKLV  GFV+R    K  +LIP++ G++L  VLP
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQR----KGKQLIPTKDGINLAVVLP  539

Query  527  EQLQSPLLTAEWENRLKQVEHGKLEPDAFMNGISSMLRELIKTYTPVKGA-EVLFPSGRE  585
            E L SP LTAEWENRL ++  G+ +PD FM+GI +  REL++TY+ +    + LF + R 
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  586  AVGKCPRCGGSVTESKKGFFCENDGCRFGLWKDNRffaakkkvltkavaaaflkDGRVRL  645
            ++G CPRCG +V E+KK ++C N +C+F +WK++RFF  +KK +T  +AAA+LK G+V++
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  646  TGCYSEKTGKTYDATVILEDTGGR-VNFKLE  675
             G YS KTGKTYD+TV+L DTGG+ VN+++E
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

21) FP2_09300 in NC_021042


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  611 bits (2310),  Expect = 4e-176, Method: Compositional matrix adjust.
 Identities = 349/691 (51%), Positives = 493/691 (72%), Gaps = 13/691 (1%)

Query  2    KLVLAEKPSVAQSIAKVLGAAKREDGYLEGNGYVVSWCVGHLVELAQPEVYDAKYSKWAY  61
            KLV+AEKPSVA+SIA V+GA+ ++DGYLEGNGY+VSWC+GHLV +A++  YD ++ KW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIFPMDWQYEVSAGTKKQFGILKKLMAREDVASLVCATDAGREGELIFRLVYHKAGC  121
             DLPI+P  WQY V+ + K+QF++L  LM R DV++LVCATDAGREGELIFR+VY+ AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  RKPFERLWISSMEDVAIKEGFENLRSGTEYDALYEAALCRERADWIVGINATRLFSTLYG  181
            +KPFERLWISSMED AIK+GF +L++G +YD+LY++ALCR +ADW++GINATRLFS LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QTLNVGRVMTPTLAMAVMREAAISAFKPELFYTVQIGLDGFTAASERFKTKAAAEAVKQS  241
            + L VGRV TPTL M V R+A I+ FK E +  V+I  +G  A S RF   A A++VK +
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  C--SVAIVQKAECKEKTEKPPALYDLTSLQREANRVLGYTAQQTLDYTQNLYEKKLVTYP  299
            C  + A+        KTE+PP LYDLT+LQREANR++GYTA+QTLDY+Q LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  300  RTDSRFLTEDMAHSLTDLVKLAFHTFPVEDVDNIPVHAEQVVNNKKVTDHHAIIPTRELQ  359
            RTDS++LT+DM  ++  LV    +  P     N++ + ++++N+KKV+DHHAIIPT E+ 
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  360  KCNLSELPKGELAILQLISNRLCVAVGDPHRYAETVIELDCGGTVFSTKGKTVVQDGWKA  419
            K  ++ L+ +E  +L LI  +L  AV++PH Y      + C+G  F++KGKTV+  GWK 
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  420  LVQ------KNDSTKSDENVQTLPSVSVGDEMTVSGTEIKEGKTSPPKHFTEDTLLSAME  473
            + +      K D+    E V+ LP +  G+  +  ++ + E  T+PPK +TEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  474  TAGADEMPDEVERKGLGTPATRAGIIEKLVRIGFLERKGDKKTKHLIPTHKGTALVTVMP  533
             AGA++MP++ ERKGLGTPATRA+I+EKLV++GF++RKG    K+LIPT  G  L  V+P
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKG----KQLIPTKDGINLAVVLP  539

Query  534  EQIQSPSMTADWEEKLLLIEKGEYASEDFMDEIKDVIAGLIQNYEVIRDS-EVMMSKEAN  592
            E + SP +TA+WE++L  I KG+  +++FMD I      L+Q Y  I +  + +   E  
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  593  SIGKCPLCGSAVEDKAKAFFCSNRACKFALWKNNRYFASIGKSMTSATAQKLLGSGKVKL  652
            +IG CP CG AV +  K ++C+NRAC+F +WKN+R+F    K+ T+  A  LL +GKVK+
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  653  KNCKSERTGNTFDATVFMEVSDDGKTKFSME  683
            K   S +TG+T+D+TV++  +++   ++ +E
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

22) EC1_10280 in NC_021019


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  611 bits (2307),  Expect = 7e-176, Method: Compositional matrix adjust.
 Identities = 378/691 (55%), Positives = 510/691 (74%), Gaps = 6/691 (0%)

Query  2    NLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDQKYAKWRY  61
            +LVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD+++ KWRY
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPILPEHWQMVVGkdkkkqfdilkklMNAPDMTEVVNACDAGREGEMIFRSVYELAGC  121
            +DLPILPE WQ +V  DKK+QFD+L  LM+ PD+T +V A DAGREGE+IFR VY++AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPMKRLWISSMEDSAIREGFANLRPSADYDGLRDAALCRAKADWLVGINATRLFSVLYH  181
            +KP  RLWISSMEDSAI++GFA+L+P++DYD L ++ALCRAKADWL+GINATRLFSVLYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  RTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERVANKAAAEQLKEA  241
            + L +GRV +PTL ++V+R+A I  FK   +  V +   G    + R ++ A A+ +K A
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CQGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYP  301
            C  A+     V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSRYLTGDMADSLPVLVNLVASAMPFRKGIAITCDPHTVINDKKVTDHHAVIPTRNLK  361
            RTDS+YLT+DM  ++  LV+ +   +PF KG+ ++ + + ++N KKV+DHHA+IPT ++ 
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  362  DADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWKA  421
              ++++L+ +EK +L L+  +L+CAVA PHIY       +CAG EFT+KGKTV  PGWK 
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  422  LEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAME  481
            +E  +R+ +K          + LPEL EGQT++  AA V E  ++PP+ +TEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  482  TAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLP  541
             AG EDMPEDAERKGLGTPATRA+ILEKLV  GF++RK      QL+P+ D+++L  VLP
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAVVLP  539

Query  542  EQLQSPLLTAEWEYRLGEIERGQLAPEEFLAGISTMLKDLVGTYQVIK-GTEYLFTPLRE  600
            E L SP LTAEWE RL EI +GQ  P+EF+ GI T  ++LV TY  I    + LF + R 
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  601  VVGKCPRCGVEVAELQKGFFCQNDSCKFAIwknnkwwaakkkQPTKAVVSALLNDGRVRV  660
             +G CPRCG  V E +K ++C N +C+F +WKN++    +KK  T  + +ALL+ G+V+V
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  661  TGLYSEKTGKTYDATVVLED-DGQYANFKLE  690
             GLYS KTGKTYD+TV+L D +G+Y N+++E
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

23) RHOM_01890 in NC_015977


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  609 bits (2299),  Expect = 3e-175, Method: Compositional matrix adjust.
 Identities = 379/692 (55%), Positives = 508/692 (74%), Gaps = 6/692 (0%)

Query  4    HKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWR  63
             KLVIAEKPSVA+S+A+VIGAT + DGYLEGNG  VSWC+GHL ++ADA+ YD ++ KWR
Sbjct  3    YKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWR  62

Query  64   YDDLPILPEHWQMVVGkdkkkqfdilkklMNAPDVTEVVNACDAGREGEMIFRSVYELAG  123
            Y+DLPILPE WQ +V  DKK+QFD+L  LM+ PDVT +V A DAGREGE+IFR VY++AG
Sbjct  63   YEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAG  122

Query  124  CKKPMKRLWISSMEDSAIRKGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLY  183
            C+KP  RLWISSMEDSAI+ GFA+L+PG+DYD L ++ALCRAKADWL+GINATRLFSVLY
Sbjct  123  CQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLY  182

Query  184  HRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERMADKAAAEQLKE  243
            H+ L +GRV +PTL ++V+R+A I  FK   +  V +   G    + R +D A A+ +K 
Sbjct  183  HKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKA  242

Query  244  ACQGVNVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTY  303
            AC   +     V    K+E+PP LYDLTTLQR+ANRL+G+TA+QTLDY Q+LY KKL TY
Sbjct  243  ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  304  PRTDSRYLTGDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNL  363
            PRTDS+YLT+DM  ++  LV+ + + +PF KG+ ++ + + ++N KKV+DHHA+IPT ++
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  364  KDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWK  423
               ++++L+ +EK +L L+  +L+CAVA PHIY       +CAG EFT+KGKTV  PGWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  424  ALEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSLPQHFTEDTLLSAM  483
             +E  +R+ +K          + LPEL EGQT++  AA V E  ++ P+ +TEDTLLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  484  ETAGKDDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKNRKTVQLLPSHDAVSLITVL  543
            E AG +DMPEDAERKGLGTPATRA+ILEKLV  GF++RK +    QL+P+ D+++L  VL
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGK----QLIPTKDGINLAVVL  538

Query  544  PEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIK-GTEYLFTPPR  602
            PE L SP LTAEWE RL EI +GQ  P+EF+DGI T  ++LV TY  I    + LF + R
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAER  598

Query  603  EVVGKCPRCGGEVAELQKGFFCQNDSCKFAIwknnkwwaakkkQPTKAVVSALLNDGCVR  662
              +G CPRCG  V E +K ++C N +C+F +WKN++    +KK  T  + +ALL+ G V+
Sbjct  599  VPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVK  658

Query  663  VTGLYSEKTGKTYDAAVVLED-DGQYANFKLE  693
            V GLYS KTGKTYD++V+L D +G+Y N+++E
Sbjct  659  VKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

24) topB in NC_016048


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  594 bits (2243),  Expect = 7e-171, Method: Compositional matrix adjust.
 Identities = 363/691 (53%), Positives = 499/691 (73%), Gaps = 21/691 (3%)

Query  2    KLVIAEKPSVAQSIAAVLGAKQRGGGYLEGSGWLVSWCFGHLAELASAESYNPEYAKWKY  61
            KLVIAEKPSVA+SIA+V+GA ++ +GYLEG+G LVSWC+GHL  +A A  Y+  + KW+Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPIVPETWRFKVSRDKWQQFDILKKLMHSEDVSEVVNACDAGREGELIFRTAYCLAGC  121
            +DLPI+PETW++ V+ DK QQFD+L  LM+  DV+ +V A DAGREGELIFR  Y +AGC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  SKPMKRLWISSMEDSAIRDGFAHLRPGSDYDGLHQSALCRSKADWLVGINATRLFSVLYH  181
             KP  RLWISSMEDSAI+DGFAHL+PG+DYD L QSALCR+KADWL+GINATRLFSVLYH
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  RTLNVGRVMSPTLALIVQREAEIDAFRAEPFYTVELDVGFP-AVSEKFREESqakavaaa  240
            + L VGRV +PTL ++V+R+A I  F+ E +  V++  G + AVS +F + ++A++V AA
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  241  cqgqpaavksverkeksekAPALYDLTTLQRNANRLLGYTAQQTLDYLQSLYEKKLCTYP  300
            C    A   SV R  K+E++P LYDLTTLQR+ANRL+GYTA+QTLDY Q+LY KKL TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDARFLTDDMEGSVPALVSV--AATLYEAAAPGKIGAAQICDSKNVSDHHALVPTVSAG  358
            RTD+++LTDDM  +V +LVS       +  +        +I +SK+VSDHHA++PT    
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  359  KAALSALPAGERKILRLVSRQLLCAVSEACRYAETVAAVECGGSVFTAKGRTVLAPGWKN  418
            K ++++L+ +E+K+L L+  +LLCAV+ +  Y    A+  C+G  FTAKG+TVL+PGWK+
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  419  YI------------QQEQPEKPLPDLTDGQALTVSGISTKEGKMTPPKHYTEDTLLSAME  466
                          ++ ++ + LP+L +GQ+++  + S  E   TPPK YTEDTLLSAME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  467  VAGAKETPDDAERKGLGTPATRAAILEKLVSTGFVERKKAKKTVSLMPSHTGVSLITVLP  526
             AGA + P+DAERKGLGTPATRAAILEKLV  GFV+RK  +    L+P+  G++L  VLP
Sbjct  484  RAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQ----LIPTKDGINLAVVLP  539

Query  527  EQLQSPLLTAEWEQKLKQVERGELTADAFLDGITAMLRELVKTYKAIKGA-EVLFPSGRE  585
            E L SP LTAEWE++L ++ +G+  +D F+DGI +  RELV+TY  I    + LF + R 
Sbjct  540  EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERV  599

Query  586  VVGKCPRCGGDVTESKKGFFCESADCRFGLWRDNKFLTAKRAVLDKKAVTALLKTGRVAM  645
             +G CPRCG  V E+KK ++C +  C+F +W++++F+  ++  +  K  +ALLKTG+V +
Sbjct  600  PIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKV  659

Query  646  TGLYSEKTGKTYDATLVLEDDGQR-ANFKLE  675
             GLYS KTGKTYD+T++L D G +  N+++E
Sbjct  660  KGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

25) CK5_35660 in NC_021022


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  589 bits (2225),  Expect = 2e-169, Method: Compositional matrix adjust.
 Identities = 343/681 (51%), Positives = 479/681 (71%), Gaps = 2/681 (0%)

Query  5    LVIAEKPSVAQSLAKNLSAYQRKDGYLEGNSCIVSWCLGHLAEYAPPEIYDEKYAKWQFE  64
            LVIAEKPSVA+S+A  ++A ++ DGYLEGN+ +VSWC+GHL  +A +  YDE++ KW++E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  65   DLPIIPKVWKVQVSEDKKKQFDVLCNLINRADVAYLVNGCDAGREGELIFKRVYDLAGCQ  124
            DLPI+P  W+  V++DKK+QFDVLC+L++R+DV+ LV + DAGREGELIF+ VY++AGCQ
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  125  KPVKRLWISSMEDEAIQKGFQSLTDGREYAGLCNAAVCRAQADWLIGMNATRAYTTRYFK  184
            KP  RLWISSMED AI+ GF  L  G +Y  L ++A+CRA+ADWLIG+NATR ++  Y K
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  185  RLVVGRVQTPTLAMLTERKEKIEHFKKEAYYKVSLSDGKLMVTSESIPLEMEAEELRKLC  244
             L VGRVQTPTL ML +R  KI +FKKE Y  V ++ G     S  ++   EA+ ++  C
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  245  DGTEALVTRVKREQKKTFPPKLYDLTSLQREANRFFGYTAQKTLDMLQELYEEKMVTYPR  304
              ++A+   V RE+K   PPKLYDLT+LQREANR+FGYTA++TLD  Q LY  K++TYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  305  TDSQYVTEDMKETVKMLAEGMTGFLPFLESGQTRGNIDRVVNNAKVSDHHAILPTKEAME  364
            TDSQY+T+DM  +V  L  G+  ++PF  + +   ++DR++N+ KVSDHHAI+PT E + 
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVK  364

Query  365  KGMGGLSSGKKNLLMLIGQQLVQATGEEYLYEQTEISVQCKEHEFAAKGKLSVQMGFKEV  424
            +G G L+ + K+LL LI  +L+ A +   +YE    +  C  +EF+AKGK  +  G KE+
Sbjct  365  QGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEI  424

Query  425  EEAFRKYCVKDKKSDEPDNKTELSEGYEEGMILASVKAEKSTHYTSPPKMFTEDTLLAAM  484
            E  FR   +K    ++++   EL+E   EG  +A V A  + H+T+PPK +TEDTLL+AM
Sbjct  425  ERRFRS-SLKTDADEDAEAVRELPELC-EGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  485  ETAGNKEFDSETEKKGLGTPATRANIIEKLVSSGYAERKGKQILPTVAGCELIHVMPENL  544
            E AG  +   ++E+KGLGTPATRA I+EKLV  G+ +RKGKQ++PT  G +L  V+PE L
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  545  KSASLTAEWENLLLMMEKGKIQEDEFMNGIVSMINEILSLCRAIPEEERNRFQTAREVIG  604
             S+ LTAEWEN L  + KG+ + DEFM+GI +   E++     I+EE ++ FQ+ R  IG
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIG  602

Query  605  KCPVCGSDVYEGKTNYYCSDRSCQFALWKSNRFLESMKKSMDKKMAVELLKKGRTHVKGL  664
             CP CG  VYEGK NYYC++R+CQF +WK++RF+E  KK+   K+A  LLK G+  VKGL
Sbjct  603  TCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGL  662

Query  665  YSKKKDSKFDADLVLGVEEGK  685
            YS K +  +D+ ++L+   GK
Sbjct  663  YSVKTGKTYDGTVLLADTGGK  683

26) Closa_3709 in NC_014376


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  574 bits (2168),  Expect = 6e-165, Method: Compositional matrix adjust.
 Identities = 339/692 (49%), Positives = 484/692 (70%), Gaps = 11/692 (1%)

Query  2    KLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRY  61
            KLV+AEKPSVA S++ VIGA ++ DGY+EGNGY+VSWC+GHLV ++++  YDE++ KWRY
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGC  121
            +DLPILPE WQY V+   K+QF++L  LM R DV +L+CATDAGREGELIFR+VY+  GC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYG  181
            +KP ERLWISSMEDSAI++GF  L+PG +YD+LY++ALCR +ADW++GINATRLFS LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMkekaeaeklvae  241
            + L VGRV TPTL M+V RDA I  FK E +   ++   + +A + R  + AEA+ + A 
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTY  301
            C +A +  ++ V +  K+E+PP L+DLT+LQREANR +G+TA+QTLDY+QALY KKL+TY
Sbjct  244  CAKAQAVCVS-VTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTY  302

Query  302  PRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTA  361
            PRTDS+YLTDDM P V  LVS + +   +  ++  + +  +++NSKKV+DHHAIIPT   
Sbjct  303  PRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEF  362

Query  362  AGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGW-  420
              +++++L+ +E+ +L ++  +L+CAV+ P  Y        CAGQ F +KGKTV   GW 
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  421  ---RQYAGRSSEDAEKNAEAC-NLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAM  476
               R++ +    DA+ +AEA  +LPEL EG T+   +  + E  T+PPK +TED LLSAM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  477  ESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVV  536
            E A++++ P + ERKG+GTPATRAAI+EKLVQ GF++R+G +    L +T  G  L  V+
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQ----LIPTKDGINLAVVL  538

Query  537  PEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGA-DVLMQPER  595
            PE + SP +TA+WE++L  I  G+ D+D FM+ I +    LV+TY  +    + L Q+ER
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAER  598

Query  596  KVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKAR  655
              IG+CP CG  V E  K  +C +++C+F +WK++RFF+   K  T  +A  L++ GK +
Sbjct  599  VPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVK  658

Query  656  LTHCYSRKSNRYYDTTVRVETGEDGAAAFKLE  687
            +   YS K+ + YD TV +    +    +++E
Sbjct  659  VKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

27) CK5_04590 in NC_021022


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  556 bits (2100),  Expect = 1e-159, Method: Compositional matrix adjust.
 Identities = 329/681 (49%), Positives = 474/681 (70%), Gaps = 2/681 (0%)

Query  5    LVIAEKPSVAQSYAKNLSAYKKEDGYLEGESCIVSWCLGHLAEYAQPEEYDPKYEKWQFD  64
            LVIAEKPSVA+S A  ++A  K+DGYLEG++ +VSWC+GHL  +A++  YD ++ KW+++
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  65   DLPILPQVWKLKVSRDKKKQFDVLKSLMNRADVDYLVNGCDAGREGELIFQRVYDLAGCR  124
            DLPILP+ W+  V+ DKK+QFDVL SLM+R+DV  LV + DAGREGELIF+ VY++AGC+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  125  KPVKRLWISSMEDTAIRTGFQTMKGAEEYRNICMAAVCRAQADWLIGMNGTRAYTTCYFK  184
            KP  RLWISSMED+AI+ GF  +K + +Y  +  +A+CRA+ADWLIG+N+TR ++  Y K
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  185  RLVVGRVQTPTLAMLAERQDKIEHFQKEAFYKVALTDGRLTVVSENIANEEAADLLASLC  244
             L VGRVQTPTL ML +R+ KI +F+KE +  V +T G    VS  +++   A+ + + C
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  245  MGSEAVITQVKKEQKKAFPPKLYDLTSLQREANRYFGYTAKKTLDMLQELYEEKLVTYPR  304
              ++AV   V +E+K   PPKLYDLT+LQREANR FGYTAK+TLD  Q LY  KL+TYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  305  TDSQFVTEDMRDTVEELVGKMPVLLPFLDYGQLGHNITRVINNAKVSDHHAILPTKEAVE  364
            TDSQ++T+DM  +VE LV+ +  L+PF    +L+ ++ R++N+ KVSDHHAI+PT E V 
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVK  364

Query  365  KGISDLPADKKNLMMLVCQQLVQATGEEYQYEQTDITVKCQEHDFTARGKVPVQMGFKEA  424
            +G++ L+   K+L+ L+C +L+ A +    YE    T  C  ++FTA+GK  +  G KE 
Sbjct  365  QGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEI  424

Query  425  GNAFKNQCVKAkpeeeteketSIPYSYEEGMTLSPVKAEKTVHFTSPPKPFNEDTLLAAM  484
               F++  +K+ ++E++E    +P    EG T++ V A  T HFT+PPKP+ EDTLL+AM
Sbjct  425  ERRFRSS-LKTDADEDAEAVRELP-ELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  485  ETAGNKDFDSETEKKGLGTPATKAGIIEKLVSSGYAVRKGKQILPSTEGRELVNVMPAYL  544
            E AG  D   ++E+KGLGTPAT+A+I+EKLV  G+  RKGKQ++P+ +G +L  V+P  L
Sbjct  483  ERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  545  KSAAMTAEWENQLLMMEKGQITDTQFMGEITSLVGKILSVCREIPEVERRRFQKAREVIG  604
             S+ +TAEWEN+L  + KGQ    +FM+ I +    ++     I+E  ++ FQ  R  IG
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIG  602

Query  605  KCPVCGSDVYEGKQNFYCSNRQCDFALWKENRFLGSMEKTLDKKMAVELLDKACTHVKGL  664
             CP CG  VYEGK+N+YC+NR C+F +WK++RF+    K++  K+A  LL  +   VKGL
Sbjct  603  TCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKGL  662

Query  665  YSRKKDIKFDADLLLTLEDGK  685
            YS K +  +D+ +LL+  +GK
Sbjct  663  YSVKTGKTYDGTVLLADTGGK  683

28) CC1_26110 in NC_021009


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  555 bits (2095),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 331/683 (49%), Positives = 485/683 (72%), Gaps = 5/683 (0%)

Query  3    LVIAEKPSVSKAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYE  62
            LVIAEKPSV+++IA VIGA E++DGYL+G + +VSWC+GHL  +  ++ YDE+F++WRYE
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  63   DLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDLSGSK  122
            DLPI+P  W+  V++DKK+QF +L  L++ P++  +V A DAGREGELIF+ VY+++G +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  123  KPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATRAYTTKYFK  182
            KP  RLWISS+EDSAI DG  HL+++ +Y  L ++A+CR++ADWL+G+NATR ++  Y K
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  183  KLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGIPAVKPKIFDPDEAEQLRSRC  242
            +LTVGRVQTPTL MLV+R ++I++F+KEKY  V++  +G  AV +++ D+ EA+ +++ C
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  243  QGSEAIvtavketekkvkaPKLYDLTTLQREANRIYGMTAKQTLDTAQSLYEKKLITYPR  302
              ++A+  +V    K  ++PKLYDLTTLQREANR++G TAKQTLD AQ+LY KKL+TYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  303  TDSQYLTEDMEQTARNVVRQIYEKYQLTGPFDQPEQPDVKKVMNNSKVTDHHAIIPTMEL  362
            TDSQYLT+DM  +  ++V  + E   ++  ++ +  P+  +++N+ KV+DHHAIIPT E+
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLS--PQFDRILNSKKVSDHHAIIPTAEF  362

Query  363  ASCHLDELKSWEEKILFLIAVHTVMAMSKDHIYqeteievecqeeiFKAKGKIVLQDGWK  422
                ++ L   E K+L LI    + A++  HIY+       C  + F AKGK VL  GWK
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  423  LFENCFKNKDRMAIVDPDQEMKERMPKVTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAA  482
             +E  F++  +    +  + ++E +P + +GQTF  V A  TEHFT+PPKPY+EDTLL+A
Sbjct  423  EIERRFRSSLKTDADEDAEAVRE-LPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSA  481

Query  483  METAGNKEFDEDTEKKGLGTPATRAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDF  542
            ME AG  +  ED+E+KGLGTPATRA+I+EKLV   +  RKGKQ+IPT DG  L  +LP+ 
Sbjct  482  MERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  543  LKSASMTAEWENQLLLMEHGEIAPEQFMTGIKNMLTMMLNGCDAISEEETRRFQT-RESI  601
            L S+ +TAEWEN+L  +  G+  P++FM GI      +++    ISEE  + FQ+ R +I
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPI  601

Query  602  GTCPVCGSLVYESKTNFYCSNHDCHFALWKDNRYLQSMEKNMDKKMAAELLKSGCVHVKD  661
            GTCP CG  VYE+K N+YC+N+ C+F +WK++R+++   K    K+AA LLK+G V VK+
Sbjct  602  GTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVKG  661

Query  662  LYSRKKNMYFEADLHMDADETGR  684
            LYS K    +++ + + AD  G+
Sbjct  662  LYSVKTGKTYDGTVLL-ADTGGK  683

29) FP2_00540 in NC_021042


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  546 bits (2062),  Expect = 1e-156, Method: Compositional matrix adjust.
 Identities = 312/617 (51%), Positives = 447/617 (73%), Gaps = 15/617 (2%)

Query  4    AKVLGATNRQDGYLEGNGYLVSWCIGHLVELAPPNVYDEKFIKWSIADLPILPEKWQYLV  63
            A V+GAT+++DGYLEGNGYLVSWCIGHLV +A +  YDE+F KW   DLPILPE WQY+V
Sbjct  18   AGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYEDLPILPETWQYIV  77

Query  64   SASTKKQFGVLQKLMHRPDVDSIVNSCDSGREGELIFRLVYQQAGCKKPFSRLWLSSMEE  123
            +   K+QF+VL  LM+RPDV ++V + D+GREGELIFR+VYQ AGC+KPF RLW+SSME+
Sbjct  78   PDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQKPFERLWISSMED  137

Query  124  NAIRESFAHLKPSTEYDALYNAALCRERADWIVGINASRLFSCLYNQPLAVGRVMTPVLA  183
            +AI+++FAHLKP+ +YD+LY++ALCR +ADW++GINA+RLFS LY++ L+VGRV TP L 
Sbjct  138  SAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHKNLTVGRVQTPTLK  197

Query  184  MTVVREAAISAFVPEKFYTVALTLADGGTASSKRFAQKADAELLLSKCRKEGRVTVQKME  243
            M V R+A I+ F  EK+  V +T A+G+ A S RF++ A+A+ + + C K   V V  + 
Sbjct  198  MLVDRDAKITDFKKEKYHIVHIT-AGGADAVSSRFSDAAEANTVKAACAKAQAVCV-SVT  255

Query  244  RKEKSENPPQLYDLTALQRDANRLLGFTAQQTLDYAQSLYEKRLITYPRTDSRFLTEDMA  303
            R  K+E+PP+LYDLT+LQR+ANRL+G+TA+QTLDYAQ+LY K+L+TYPRTDS++LT+DM 
Sbjct  256  REKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPRTDSQYLTDDML  315

Query  304  ASLPGLVTD--TGRAFTVEESFPIHVQQVINGSKVTDHHALLPTKSMANADLAALPAGER  361
            +++ +LV++     +F+   +++ + ++++N+ KV+DHHA++PT    + ++++L+ +E+
Sbjct  316  PAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVKQGFGTLAESEK  375

Query  362  NVLRLIAARLLCAVGEPHRYAETTLTTICAGEEFSAKGKVVLSDGWKAMERKMLGELLGK  421
            ++L LI  +LLCAV+ PH Y   T T  CAG+EF+AKGK VLS GWK +ER+  + L   
Sbjct  376  KLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEIERRFRSSLKTD  435

Query  422  QKEPA----VLPDVQEQSRCSVSGAELKEGQTSPPKHFTEDLLLHAMETASADSMPEGVE  477
              E A     LP++ E    +  +A + E  T+PPK +TED LL AME A+A+ MPE+ E
Sbjct  436  ADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAMERAGAEDMPEDAE  495

Query  478  RQGIGTPATRAATIEKLVQKGFLERKGSKKTKVLLPTDKGKALITVMPEEIQSADMTADW  537
            R+G+GTPATRAA +EKLVQ GF++RKG    K L+PT  G  L  V+PE + S+++TA+W
Sbjct  496  RKGLGTPATRAAILEKLVQMGFVQRKG----KQLIPTKDGINLAVVLPEALTSPQLTAEW  551

Query  538  EAKLLQIERGEMEPSEFMTEINMMITELVKNTE-MKKGANALMKSK--IIGVCPNCGANV  594
            E +L +I +G+ +P EFM  I+    ELV+    +    + L ++    IG CP CG  V
Sbjct  552  ENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVPIGTCPRCGEAV  611

Query  595  VEREKGWFCENRECRFV  611
             E  K  +C NR C+FV
Sbjct  612  YEGKKNYYCGNRACQFV  628

30) topB in NC_018867


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  529 bits (1998),  Expect = 2e-151, Method: Compositional matrix adjust.
 Identities = 354/694 (52%), Positives = 489/694 (71%), Gaps = 17/694 (2%)

Query  2    NLVIAEKPSVAQSIATVLGATKRQDGYLEGNSYIVSWCVGHLVELATADTYDERYAKWEY  61
            +LVIAEKPSVA+SIA V+GAT ++DGYLEGN+Y+VSWC+GHLV +A A+ YDER+ KW Y
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPILPENWQYSISKGKEKQVKILKELANRKDVAVITSATDAGREGELIFRLVYEKIGC  121
             DLPILPE WQY ++ +K +Q  +L  L +R DV+ +  ATDAGREGELIFR+VY+  GC
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKPVKRLWISSMEESAISEGFKALRDSTYYDALYQVALCRAKADWIVGINATRLFSVLYG  181
            +KP  RLWISSME+SAI +GF  L+ +  YD+LYQ ALCRAKADW++GINATRLFSVLY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QTLNVGRVMSPTLAMIVEREAAISAFKPEPFYTVLLDCGTFILSCEKLTDRQAAEDLRKA  241
            + L VGRV +PTL M+V+R+A I+ FK E +  V +  G       +++D   A+ ++ A
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  CDGQTIAIHSVeskeksekppkLYDLTTLQREANRQLGFTAEQTLSYAQSLYEKKLVTYP  301
            C        SV    K+E+PPKLYDLTTLQREANR +G+TA QTL YAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  302  RTDSRYLTSDMSESTPAVAKAAAGIF----MPKNLEPSIFMEQVTDNGKVSDHHAIIPTM  357
            RTDS+YLT DM    PAV    +G+      +K L+ S   +++ ++ KVSDHHAIIPT 
Sbjct  304  RTDSQYLTDDM---LPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  358  NIQDCDLYSLPFGEREVLLLISLRLACAVNESCKYEETTVTAIVSGAEFTAKGKTILSEG  417
            ++   ++ +L+ +E+ +L LI  +L CAV  +  YE  T T   +G EFTAKGKT+LS G
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  418  FRGIEKSYHAMQKDKQPVEKEKV--LPSITTGQTF-DTKAMIKEGKTSPPKHFTDDTIla  474
             + IE+ +++  K     + E V  LP +  GQTF D  A + E  T+PPK +T+DT+L+
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  475  am--enannaleDSERKGIGTPATRAGilekliktelleRKGDKKTKHFLPTQKGVSLIT  532
            AM    A++  ED+ERKG+GTPATRA+ILEKL++  +++RKG    K+++PT+ G++L  
Sbjct  481  AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKG----KQLIPTKDGINLAV  536

Query  533  VLPEAIQSPQLTAEWEEKLKQIEHGLLSPDSFLQEISQMTKSLIRTYEVIKGS-DVLFPS  591
            VLPEA+ SPQLTAEWE++L +I  G   PD F++ I   ++ L++TY  I    + LF +
Sbjct  537  VLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQA  596

Query  592  VQEAIGKCPRCGNDVIENQKGFCCLNKTCGFALWKENkfftakkkkltktIAVELLKNGK  651
             + +IG CPRCG+ V E +K + C N++C F +WK+++FF  +KK +T  IA  LLK GK
Sbjct  597  ERVPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  652  AKLPGCYSEKTGKTYDAIVLIDETDSKYVNFKME  685
             K+ G YS KTGKTYD+ VL+ +T++KYVN+++E
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690

31) SII_1009 in NC_022237


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  436 bits (1641),  Expect = 2e-123, Method: Compositional matrix adjust.
 Identities = 273/583 (47%), Positives = 393/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPSDYKYEVSKSTKKQFNILKKLMNDKDIETVVNACDAGREGESIFRFVYNEAKC  121
             DLPI+P   +Y V+   K+QF++L  LM+  D+  +V A DAGREGE IFRFVY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KNKMQRLWISSMEDSAIKEGFENLKDGKDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            ++  +RLWISSMEDSAIK+GF +LK G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYSVELSTNGFTLSTDRIDDEVTAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEI-TDVIQNEKITKPNLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   V ++ K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKVVFNSKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSNIPESEVKVYRLISNKLHASVGYPLVESTTKIVAEFDGFEFTSSGKVIKDEGFT-  411
             ++++ ++ESE K+  LI  KL  +V+ P +  +        G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLKEYKSKKNEDA----EFPDVSVGDILSIENKEIKEKFTQPPKHFTEDTLLKSME  464
               ++    K+  +EDA    E+P++  G+ ++     + E FT PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVADN  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  ++++ 
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLEAIENELKEAVLTYS  567
            + S++ TA WE  L++IA+G++  +EF+++IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

32) SCI_1283 in NC_022238


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  435 bits (1637),  Expect = 5e-123, Method: Compositional matrix adjust.
 Identities = 272/583 (47%), Positives = 392/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYKVSWCVGHLIQMANPDAYNEKYAKWNI  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ Y+E++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPIIPSDYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYSEAKC  121
            EDLPI+P   +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY  A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMQRLWISSMEDSAIKEGFSNLKNGEDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            +K  +RLWISSMEDSAIK+GF++LK G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLYMIVKRDDEISNFKKEKYYTVELSTNGFTLSTDRIDDEVAAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEI-IDVIQKEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    + + V +  K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMITST---VNNILGKNDFD-----TERIKVVFDFKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  +++ KKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPESEAKVYRLISNKLHASVGYPLIENTTKIVASFDGFEFTSAGKVVKDDGFT-  411
             ++++ ++ESE K+  LI  KL  +V+ P I ++     +  G EFT+ GK V   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLKDYKSKKNEDI----ELPDVKVGDVFEVENKEIKEKFTQPQKHFTEDTLLKSME  464
               ++    K+  +ED     ELP++  G+ F      + E FT P K +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDS  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLKDIENEIKEAVMTYS  567
            + S++ TA WE  L++IA+G++  +EF+ +IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

33) SCRE_1224 in NC_022236


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  435 bits (1637),  Expect = 5e-123, Method: Compositional matrix adjust.
 Identities = 272/583 (47%), Positives = 392/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYKVSWCVGHLIQMANPDAYNEKYAKWNI  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ Y+E++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPIIPSDYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYSEAKC  121
            EDLPI+P   +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY  A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMQRLWISSMEDSAIKEGFSNLKNGEDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            +K  +RLWISSMEDSAIK+GF++LK G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLYMIVKRDDEISNFKKEKYYTVELSTNGFTLSTDRIDDEVAAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEI-IDVIQKEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    + + V +  K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMITST---VNNILGKNDFD-----TERIKVVFDFKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  +++ KKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPESEAKVYRLISNKLHASVGYPLIENTTKIVASFDGFEFTSAGKVVKDDGFT-  411
             ++++ ++ESE K+  LI  KL  +V+ P I ++     +  G EFT+ GK V   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLKDYKSKKNEDI----ELPDVKVGDVFEVENKEIKEKFTQPQKHFTEDTLLKSME  464
               ++    K+  +ED     ELP++  G+ F      + E FT P K +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDS  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLKDIENEIKEAVMTYS  567
            + S++ TA WE  L++IA+G++  +EF+ +IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

34) SCR2_1224 in NC_022245


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  435 bits (1637),  Expect = 5e-123, Method: Compositional matrix adjust.
 Identities = 272/583 (47%), Positives = 392/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYKVSWCVGHLIQMANPDAYNEKYAKWNI  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ Y+E++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   EDLPIIPSDYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYSEAKC  121
            EDLPI+P   +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY  A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMQRLWISSMEDSAIKEGFSNLKNGEDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            +K  +RLWISSMEDSAIK+GF++LK G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLYMIVKRDDEISNFKKEKYYTVELSTNGFTLSTDRIDDEVAAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEI-IDVIQKEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    + + V +  K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMITST---VNNILGKNDFD-----TERIKVVFDFKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  +++ KKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPESEAKVYRLISNKLHASVGYPLIENTTKIVASFDGFEFTSAGKVVKDDGFT-  411
             ++++ ++ESE K+  LI  KL  +V+ P I ++     +  G EFT+ GK V   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLKDYKSKKNEDI----ELPDVKVGDVFEVENKEIKEKFTQPQKHFTEDTLLKSME  464
               ++    K+  +ED     ELP++  G+ F      + E FT P K +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDS  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLKDIENEIKEAVMTYS  567
            + S++ TA WE  L++IA+G++  +EF+ +IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

35) CD630_04210 in NC_009089


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  429 bits (1614),  Expect = 3e-121, Method: Compositional matrix adjust.
 Identities = 270/582 (47%), Positives = 389/582 (67%), Gaps = 19/582 (3%)

Query  2    KLVIAEKPSVAISIAKVIGVNKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIG   K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPSAYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNEAKC  121
             DLPI+P + +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNLKDGKGYDNLFESAQARAIADWLVGMNISRLYSCLYK  181
            +K   RLWISSMEDSAIK+GF +LK G +YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEVAAEQLINL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V+++  G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDVIQKEKITN-PDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   + +EK T+ P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMITST---INNILGKNDFDTG-----RIKTVFNSKKVTDHHAIIPTISSL  352
            RTDS+ LT+DM+ +    ++ +     F  G     ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  KEDVSKLPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGFSK  412
            K++ + L+ SE K+  LI  K+  +V+ P I ++     +  G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  YLKEYKSK------KNEDAV--LPNVSVGDVLSIENKEIKEKFTKPPKHFTEDTLLKSME  464
              + ++S        + +AV  LP++  G+ ++     + E FT PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNDALEKGVEVERKGLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVADN  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  ++++ 
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIKEAVLTY  566
            + S++ TA WE  L++IA+G++   EF+D+IE + +E V TY
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

36) SANR_1345 in NC_022239


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  428 bits (1611),  Expect = 5e-121, Method: Compositional matrix adjust.
 Identities = 270/583 (47%), Positives = 393/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIKMANPESYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGAT K DGY EGNGY VSWC+GHL+  A++  YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPKEYKYEIAKSTKKQFTILKKLMNDKDIDIVINACDAGREGEAIFRLVYNQANC  121
             DLPI+P   +Y ++   K+QF +L  LM+  D+  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKRMKRLWISSMEDSAIKEGFDNLKDGSSYDNLFESAQARAIADWLVGMNLSRLYSCLYK  181
            +K   RLWISSMEDSAIK+GF +LK G+ YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVNRDDEIANFKKEKYNTVELSLNGFTLSTDRIDDEVAAEQLINL  241
            +N +VGRVQTPTL M+V+RD  I++FKKEKY+ V+++  G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDVIQKEKIT-KPELPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKTVFNSKKVTDHHAIIPTASSM  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPTA  +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  NENLTSLPESELKVYELILNKLHASVGYPLIENTTKIVAEFDGFEFTSSGKVIVDDGFT-  411
            ++ + +L+ESE K+  LI  KL  +V+ P I ++        G EFT+ GK ++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLNEYAKKKNEDT----VLPDVKIGYSLDIKDKEIKEKYTQPAKHFTEDLLLKAME  464
               ++ +      +ED+     LP++  G ++      + E +T P+K +TED LL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  LAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVADT  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGQSSKENFLEAIENEIKEVVSTYT  567
            + S++ TA WE  L++IA+GQ+  ++F+++IE + +E+V TY+
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

37) SZO_12820 in NC_012470


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  428 bits (1612),  Expect = 5e-121, Method: Compositional matrix adjust.
 Identities = 265/583 (46%), Positives = 387/583 (67%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDVYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPKEYKYEVAKSTKKQFAILKKLLNDKEIDTVINACDAGREGESIFRLVYNQANC  121
             DLPI+P   +Y V+   K+QF +L  L++  ++  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNIKDGKDYDNLFESAQARAIADWLVGMNISRLYSCLYK  181
            +K   RLWISSMEDSAIK+GF ++K G DYD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEIAAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V+++  G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEI-TDVIQKGKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   V +  K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RSDSRCLTEDMIVNI---VNNILGKNDFD-----TERIKAVFNSKKVTDHHAIIPTVSSL  352
            R+DS+ LT+DM+  +   V+ +     F      + ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPEGEAKVYRLISDKFHASVGYPLIENTTKIVAVSDGFEFTSTGKVIKDEGFSK  412
             ++++ ++E+E K+  LI  K+  +V+ P I ++        G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  YLKEYKSK------QSEDAV--MPDISVGDVLSIENKEIKEKFTQPPKHFTEDTLLKSME  464
              + ++S       +  +AV  +P++  G+ ++     + E FT PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVTDT  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  ++ ++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLKDIENEIKEAVLTYS  567
            + S++ TA WE  L++IA+G++  +EF+ +IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

38) SANR_1304 in NC_022239


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  428 bits (1610),  Expect = 6e-121, Method: Compositional matrix adjust.
 Identities = 265/585 (46%), Positives = 398/585 (69%), Gaps = 19/585 (3%)

Query  1    MKHKLVIAEKPSVALSISKIIGANGKKDGYYEGNGYRVSWCVGHLIQMANPDSYDEKYAK  60
            M  KLVIAEKPSVA SI+ +IGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ K
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WNIEDLPIIPSEYKYEVAKATKKQFTILKKLMNDKDIDSVINACDAGREGESIFRLVYNE  120
            W  EDLPI+P   +Y V+   K+QF +L  LM+  D+ +++ A DAGREGE IFR+VY+ 
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AKCKKKMQRLWISSMEDSAIKEGFENLKDGKDYDNLFESALTRAIADWLVGMNISRLYSC  180
            A C+K  +RLWISSMEDSAIK+GF +LK G DYD L++SAL RA ADWL+G+N +RL+S 
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  LYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSLDGFNLLTDRIDDKTAAEQL  240
            LY +N +VGRVQTPTL M+V RD  I++FKKEKY  V+++ +G + ++ R+ D + A+ +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  241  FNLVGEKIEITNVIQKEKVT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLI  299
                +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+
Sbjct  241  KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL  300

Query  300  TYPRTDSRCLTEDMITST---INNILGKNDFD-----TRRIKTVFNSKKVTDHHAIIPTI  351
            TYPRTDS+ LT+DM+ +    ++ +     F      + ++  ++NSKKV+DHHAIIPT 
Sbjct  301  TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA  360

Query  352  SSLKEDVSELPLSEANVYFLISDKFHASVGYPLVENTTKIVAEFDDFEFTSTGKVIKDEG  411
              +K++ + L+ SE ++  LI  K+  +V+ P + ++        + EFT+ GK +   G
Sbjct  361  EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG  420

Query  412  FTKYLKEYK------IKNSDDVV--LPMINTGDVLEVKDKEIREKYTTPPKHFTKGTLLK  463
                 + ++        +  + V  LP +  G+ +      + E +TTPPK +T +TLL 
Sbjct  421  WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS  480

Query  464  AMEIAGSEALEKGVEVERKGLGTPATRAGIIENLIYKGFIERDKKNLIATRKGKSLIEIV  523
            AME AG+E +    + ERKGLGTPATRA+I+E+L+  GF++R  K+LI+T+ G +L  ++
Sbjct  481  AMERAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVL  538

Query  524  ADTFKSAEMTAQWEMRLSDIAQGKSSKEEFLDSIEAEIKNAVAKY  568
            ++++ S+++TA+WE RL++IA+G++  +EF+D+IE++ ++ V  Y
Sbjct  539  PEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

39) topB in NC_003030


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  427 bits (1608),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 267/661 (41%), Positives = 415/661 (63%), Gaps = 41/661 (6%)

Query  5    LVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFD  64
            LVI+EKPSV+R IA V+G   + +G L G  Y+V+W +GHLV++ ++  Y+  +KKWR++
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  65   TLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECK  124
             LPI+PE  +    D+ K+QF+++  LM+   V +L+CATDAGREGELIFR+ Y+ A C+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  125  KPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNV  184
            KPF RLWISSM D AIK+GF+ +KPG +YD LY+SA CR+ ADWL+G+NA+R +++ Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  185  LLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKA  244
             L+VGRVQTPTL ++V R+  I +F    Y ++V    G      + ++  S++ D   A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKY-HIVHITAG------GADAVSSRFSDAAEA  237

Query  245  DDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEK  304
            + + A      +  +S+   KK + PP LYDLT LQR+ N+ FG++A++TLD  Q+LY K
Sbjct  238  NTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK  297

Query  305  RKMVTYPRTDSRYLSHDMVNKIKKTIGRL-NINPYDKYVGEILKLSKLPMGKRIIDDSKV  363
             K++TYPRTDS+YL++DM+  +   ++ L ++ P+ K     L+LS  P   RI++  KV
Sbjct  298  -KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAK----GLNLS--PQFDRILNSKKV  350

Query  364  TDHHAIIPTD--VKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFL  421
            +DHHAIIPT   VK  ++TL+  E K+   I  ++LC       Y           ++F 
Sbjct  351  SDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFT  410

Query  422  TQGKTILKLGWMEF---YKHDKKEKDDENSEP-DELPKLKKNESVQVKDSEIKAKKTKAP  477
            ++GKT+L  GW E+   ++   K   DE++E+  ELP L   ++     + +    T +P
Sbjct  411  AKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPP  470

Query  478  SSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLH  537
             +YTE +LLSAME AG     E++ E+    GLGTPATRA+I+E+L+Q+G++QRKGK L 
Sbjct  471  KPYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLI  526

Query  538  PTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQ--ESV  595
            PT  G++L  ++P  L SP+ T+ WE+ L+ I+KG+  ++ FM++I    + ++Q    +
Sbjct  527  PTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCI  586

Query  596  KVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKD  655
              ++  +FQ +             +IG CP C  + VYE  K +YC+++  +C+F  WK+
Sbjct  587  SEEKQKLFQAE-----------RVPIGTCPRCGEA-VYEGKKNYYCGNR--ACQFVMWKN  632

Query  656  S  656
             
Sbjct  633  D  633

40) SMB_G3608 in NC_015687


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  427 bits (1608),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 267/661 (41%), Positives = 415/661 (63%), Gaps = 41/661 (6%)

Query  5    LVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFD  64
            LVI+EKPSV+R IA V+G   + +G L G  Y+V+W +GHLV++ ++  Y+  +KKWR++
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  65   TLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECK  124
             LPI+PE  +    D+ K+QF+++  LM+   V +L+CATDAGREGELIFR+ Y+ A C+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  125  KPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNV  184
            KPF RLWISSM D AIK+GF+ +KPG +YD LY+SA CR+ ADWL+G+NA+R +++ Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  185  LLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKA  244
             L+VGRVQTPTL ++V R+  I +F    Y ++V    G      + ++  S++ D   A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKY-HIVHITAG------GADAVSSRFSDAAEA  237

Query  245  DDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEK  304
            + + A      +  +S+   KK + PP LYDLT LQR+ N+ FG++A++TLD  Q+LY K
Sbjct  238  NTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK  297

Query  305  RKMVTYPRTDSRYLSHDMVNKIKKTIGRL-NINPYDKYVGEILKLSKLPMGKRIIDDSKV  363
             K++TYPRTDS+YL++DM+  +   ++ L ++ P+ K     L+LS  P   RI++  KV
Sbjct  298  -KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAK----GLNLS--PQFDRILNSKKV  350

Query  364  TDHHAIIPTD--VKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFL  421
            +DHHAIIPT   VK  ++TL+  E K+   I  ++LC       Y           ++F 
Sbjct  351  SDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFT  410

Query  422  TQGKTILKLGWMEF---YKHDKKEKDDENSEP-DELPKLKKNESVQVKDSEIKAKKTKAP  477
            ++GKT+L  GW E+   ++   K   DE++E+  ELP L   ++     + +    T +P
Sbjct  411  AKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPP  470

Query  478  SSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLH  537
             +YTE +LLSAME AG     E++ E+    GLGTPATRA+I+E+L+Q+G++QRKGK L 
Sbjct  471  KPYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLI  526

Query  538  PTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQ--ESV  595
            PT  G++L  ++P  L SP+ T+ WE+ L+ I+KG+  ++ FM++I    + ++Q    +
Sbjct  527  PTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCI  586

Query  596  KVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKD  655
              ++  +FQ +             +IG CP C  + VYE  K +YC+++  +C+F  WK+
Sbjct  587  SEEKQKLFQAE-----------RVPIGTCPRCGEA-VYEGKKNYYCGNR--ACQFVMWKN  632

Query  656  S  656
             
Sbjct  633  D  633

41) topB in NC_017295


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  427 bits (1608),  Expect = 1e-120, Method: Compositional matrix adjust.
 Identities = 267/661 (41%), Positives = 415/661 (63%), Gaps = 41/661 (6%)

Query  5    LVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFD  64
            LVI+EKPSV+R IA V+G   + +G L G  Y+V+W +GHLV++ ++  Y+  +KKWR++
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  65   TLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECK  124
             LPI+PE  +    D+ K+QF+++  LM+   V +L+CATDAGREGELIFR+ Y+ A C+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  125  KPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNV  184
            KPF RLWISSM D AIK+GF+ +KPG +YD LY+SA CR+ ADWL+G+NA+R +++ Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  185  LLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKA  244
             L+VGRVQTPTL ++V R+  I +F    Y ++V    G      + ++  S++ D   A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKY-HIVHITAG------GADAVSSRFSDAAEA  237

Query  245  DDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEK  304
            + + A      +  +S+   KK + PP LYDLT LQR+ N+ FG++A++TLD  Q+LY K
Sbjct  238  NTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK  297

Query  305  RKMVTYPRTDSRYLSHDMVNKIKKTIGRL-NINPYDKYVGEILKLSKLPMGKRIIDDSKV  363
             K++TYPRTDS+YL++DM+  +   ++ L ++ P+ K     L+LS  P   RI++  KV
Sbjct  298  -KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAK----GLNLS--PQFDRILNSKKV  350

Query  364  TDHHAIIPTD--VKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFL  421
            +DHHAIIPT   VK  ++TL+  E K+   I  ++LC       Y           ++F 
Sbjct  351  SDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFT  410

Query  422  TQGKTILKLGWMEF---YKHDKKEKDDENSEP-DELPKLKKNESVQVKDSEIKAKKTKAP  477
            ++GKT+L  GW E+   ++   K   DE++E+  ELP L   ++     + +    T +P
Sbjct  411  AKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPP  470

Query  478  SSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLH  537
             +YTE +LLSAME AG     E++ E+    GLGTPATRA+I+E+L+Q+G++QRKGK L 
Sbjct  471  KPYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLI  526

Query  538  PTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQ--ESV  595
            PT  G++L  ++P  L SP+ T+ WE+ L+ I+KG+  ++ FM++I    + ++Q    +
Sbjct  527  PTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCI  586

Query  596  KVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKD  655
              ++  +FQ +             +IG CP C  + VYE  K +YC+++  +C+F  WK+
Sbjct  587  SEEKQKLFQAE-----------RVPIGTCPRCGEA-VYEGKKNYYCGNR--ACQFVMWKN  632

Query  656  S  656
             
Sbjct  633  D  633

42) SDSE_1343 in NC_019042


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  426 bits (1603),  Expect = 2e-120, Method: Compositional matrix adjust.
 Identities = 268/583 (46%), Positives = 390/583 (67%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISITKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNM  61
            KLVIAEKPSVA SI+ VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIILKDYKYEVAKSTKKQFNILKKLMNDKEVDTVINACDSGREGESIFRLVYNQANC  121
             DLPI+    +Y V+   K+QF++L  LM+  +V  ++ A D+GREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKDGFDHLKDGEEYDNLFESAQARAIADWLVGMNISRLYSCLYK  181
            +K   RLWISSMEDSAIKDGF HLK G +YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVDLSTNGFTLSTDRIDDEIAAEQLLTL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ + + 
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGNKIEITDVIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             ++   +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKTVFNSKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPEGEAKVYRLISDKFHASVGYPLIENTTKIVAVFDGFEFTSSGKVIKDEGFTk  412
             ++++ ++E+E K+  LI  K+  +V+ P I ++        G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  ylkeykskkseDA--------VLPDVSVGDVLSIENKEIKEKYTQPPKHFTEDTLLKSME  464
              + ++S    DA         LP++  G+ ++     + E +T PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIAMHKGISLVTIVADN  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+   GI+L  ++++ 
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLEAIENEIKEAVSTYS  567
            + S++ TA WE  L++IA+G++  +EF+++IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

43) SDE12394_07175 in NC_017567


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  426 bits (1603),  Expect = 2e-120, Method: Compositional matrix adjust.
 Identities = 268/583 (46%), Positives = 390/583 (67%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISITKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNM  61
            KLVIAEKPSVA SI+ VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIILKDYKYEVAKSTKKQFNILKKLMNDKEVDTVINACDSGREGESIFRLVYNQANC  121
             DLPI+    +Y V+   K+QF++L  LM+  +V  ++ A D+GREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKDGFDHLKDGEEYDNLFESAQARAIADWLVGMNISRLYSCLYK  181
            +K   RLWISSMEDSAIKDGF HLK G +YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVDLSTNGFTLSTDRIDDEIAAEQLLTL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ + + 
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGNKIEITDVIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             ++   +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKTVFNSKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPEGEAKVYRLISDKFHASVGYPLIENTTKIVAVFDGFEFTSSGKVIKDEGFTk  412
             ++++ ++E+E K+  LI  K+  +V+ P I ++        G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  ylkeykskkseDA--------VLPDVSVGDVLSIENKEIKEKYTQPPKHFTEDTLLKSME  464
              + ++S    DA         LP++  G+ ++     + E +T PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIAMHKGISLVTIVADN  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+   GI+L  ++++ 
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKEEFLEAIENEIKEAVSTYS  567
            + S++ TA WE  L++IA+G++  +EF+++IE + +E V TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

44) CD630_18590 in NC_009089


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  425 bits (1601),  Expect = 3e-120, Method: Compositional matrix adjust.
 Identities = 268/583 (46%), Positives = 396/583 (68%), Gaps = 19/583 (3%)

Query  2    KLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIQMANPESYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGAT K DGY EGNGY VSWC+GHL+  A++  YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPREYKYEIAKSTKKQFTILKKLMNDKEIDIVINACDAGREGEAIFRLVYNQANC  121
             DLPI+P   +Y ++   K+QF +L  LM+  ++  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNLKDGSFYDNLFESAQARAIADWLVGMNLSRLYSCLYK  181
            +K   RLWISSMEDSAIK+GF +LK G+ YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELDLDGFSLSTDRIDDKTVTEQLINL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++  +G    + R+ D + ++ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  LGNSIEITDVIQKEKIT-KPELPFDLTTLQRECNKYFNYSAKQTLDYTQSLYEKKLITYP  300
             +++  +   + +EK T +P   +DLTTLQRE N+ F Y+AKQTLDY+Q+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRYLTEDMITSTINNIVGKHD---FDTG-----RIKMVFNSKRVTDHHAIIPTASSM  352
            RTDS+YLT+DM+ +  + + G  +   F  G     ++  ++NSK+V+DHHAIIPTA  +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  NEDLASLPESELKVYELVLNKLHASVGYPLIENTTKIVAVFDGFEFTSSGKVIVDEGFTk  412
            ++++++L+ESE K+  L+  KL  +V+ P I ++        G EFT+ GK ++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  ------ylkkyikkkNEDTV--FPDLKIGDSLDIKEKEIKENYTSPAKHFTEDTLLKDME  464
                     K     + ++V  +P+L  G+++      + E++T+P+K +TEDTLL  ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  LAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDT  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAGTTAKWEMELSDIAQGKASKENFLKAIENEIKELVSTYS  567
            + S+  TA WE  L++IA+G+A  ++F+ +IE + +ELV TYS
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

45) topA in NC_018712


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  423 bits (1592),  Expect = 2e-119, Method: Compositional matrix adjust.
 Identities = 269/583 (47%), Positives = 391/583 (68%), Gaps = 19/583 (3%)

Query  2    NLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIKMANPESYDEKYAKWNM  61
            +LVIAEKPSVA SIA VIGAT K DGY EGNGY VSWC+GHL+  A++  YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPKEYKYEIAKSTKKQFTILKKLMNDKDIDIVINACDAGREGEAIFRLVYNQANC  121
             DLPI+P   +Y ++   K+QF +L  LM+  D+  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKRMKRLWISSMEDSAIKEGFDNLKDGSSYDNLFESAQARAIADWLVGMNLSRLYSCLYK  181
            +K   RLWISSMEDSAIK+GF +LK G+ YD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELSLNGFTLSTDRIDDEITAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V+++  G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDVIQKEKIT-KPELPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKTVFNSKKVTDHHAIIPTASSM  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPTA  +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  NENLTSLPESELKVYELILNKLHASVGYPLIENTTKIVAEFDGFEFTSSGKVIVDDGFT-  411
            ++ + +L+ESE K+  LI  KL  +V+ P I ++        G EFT+ GK ++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLNEYAKKKNEDT----VLPDVKIGYSLDIKDKEIKEKYTQPAKHFTEDLLLKAME  464
               ++ +      +ED+     LP++  G ++      + E +T P+K +TED LL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  LAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVADT  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGQSSKENFLEAIENEIKEVVSTYT  567
            + S++ TA WE  L++IA+GQ+  ++F+++IE + +E+V TY+
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYS  584

46) HMPREF0389_00190 in NC_016630


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  422 bits (1587),  Expect = 4e-119, Method: Compositional matrix adjust.
 Identities = 267/587 (46%), Positives = 391/587 (67%), Gaps = 23/587 (3%)

Query  1    MEHKLVIAEKPSVAISIAKVIGAKNKKDGYYEGNGYKVSWCVGHLIQMANPDAYDEKYAK  60
            M  KLVIAEKPSVA SIA VIGA +K DGY EGNGY VSWC+GHL+  A+++ YDE++ K
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WKIDDLPIITKEYKYEVAKATKKQFAVLKKLMNDKEIDTVINACDAGREGEAIFRLVYLQ  120
            W+ +DLPI+    +Y V+   K+QF VL  LM+  ++  ++ A DAGREGE IFR+VY  
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  ASCKKKMKRLWISSMEDSAIKDGFDNLKDGNVYDNLFESAQARAIADWLVGMNISRLYSC  180
            A+C+K   RLWISSMEDSAIKDGF +LK G  YD L++SA  RA ADWL+G+N +RL+S 
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  LYKQNYSVGRVQTPTLSMIVKRDDEIANFKKEKYYTVELELDGFTLSTERIDSLEVAEQL  240
            LY +N +VGRVQTPTL M+V RD  I++FKKEKY  V++  +G    + R+     A+ +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV  240

Query  241  KNLLECRIEITDVIQTEKITKPDLP---FDLTTLQRECNKHFGYSAKQTLDYAQSLYEKK  297
            K    C    +  +   +  K + P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KK
Sbjct  241  KA--ACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKK  298

Query  298  LITYPRTDSRCLTEDMITST---VNNILGKNDFD-----TERIRVVFNSKKVTDHHAIIP  349
            L+TYPRTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIP
Sbjct  299  LLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIP  358

Query  350  TVSSMSEDLSSIPESEAKVYRLISNKLHASVGYPLIENTTKIVATFDGFEFTSSGKVIVD  409
            T   + +++++++ESE K+  LI  KL  +V+ P I ++     T  G EFT+ GK ++ 
Sbjct  359  TAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLS  418

Query  410  EGFTKYLKEYMSK------KNEEPV--LPEINVGDVLeikekeikekYTQAPKHFTENTL  461
             G     + + S        + E+V  LPE+  G+ +      + E +T +PK +TE+TL
Sbjct  419  PGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTL  478

Query  462  LKAMEIAGNDGLDKNVEVERKGLGTPATRAGIIENLIYKGFIERDKKNLIATNKGISLIT  521
            L AME AG +++    + ERKGLGTPATRA+I+E+L+  GF++R  K+LI+T+ GI+L  
Sbjct  479  LSAMERAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAV  536

Query  522  IVADTFKSAETTAKWEMELSDISQGKSSKEEFLNTIEHEIRNELSHY  568
            ++++++ S++ TA WE  L++I++G++  +EF++ IE + R+ +  Y
Sbjct  537  VLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

47) SEQ_1256 in NC_012471


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  421 bits (1583),  Expect = 9e-119, Method: Compositional matrix adjust.
 Identities = 261/581 (45%), Positives = 388/581 (67%), Gaps = 19/581 (3%)

Query  4    LVISEKPSVAISISKVLGATKKKDGYNEGNGYRVSWCVGHLIQMANPDAYDEKYAKWDMA  63
            LVI+EKPSVA SI+ V+GAT K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW   
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPIIPKDYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNQVNCK  123
            DLPI+P   +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY+   C+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KKMKRLWISSMEDSAIKEGFDHLKDGKKYDNLFESAQARAIADWLVGMNISRLYSCLYNQ  183
            K   RLWISSMEDSAIK+GF HLK G  YD L++SA  RA ADWL+G+N +RL+S LY++
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  NYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMDGFILSTDRIDDKVAAEQLINLV  243
            N +VGRVQTPTL M+V RD  I++FKKEKY  V+++ +G    + R+ D   A+ +    
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  244  GDKIEI-TDVIQNEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPR  302
            +    +   V ++ K  +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  303  TDSRCLTEDMIT---SMINNILGQNDFDTG-----RIKVIFNSSKVTDHHAIIPTVSSMS  354
            TDS+ LT+DM+    S+++ +     F  G     ++  I+NS KV+DHHAIIPT   + 
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVK  364

Query  355  EDLLSIPESEAKVYGLIFNKLHASVGYPLIENTTKIVVTFDGFKFTSSGKVIKDEGFT--  412
            +++ +++ESE K+ +LI  KL  +V+ P I ++     T  G  FT+ GK +   G    
Sbjct  365  QGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEI  424

Query  413  --KYLKEYKTKKNEDI----ELPNVNIGDSLKIKDKEIKEKYTQPPKHFTENTLLKSMET  466
              ++    KT  +ED     ELP++  G+++      + E +T PPK +TE+TLL +ME 
Sbjct  425  ERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAMER  484

Query  467  AGNDALKKGIEVERKGIGTPATRAGIIENLIYKGFIQRDKKNLVATHKGISLITIVADNF  526
            AG + +    + ERKG+GTPATRA+I+E+L+  GF+QR  K+L++T  GI+L  ++++ +
Sbjct  485  AGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  527  KSAETTAKWEMELSDISQGKSSKEEFLRRVEAEIRNELSRY  567
             S++ TA WE  L++I++G++  +EF+  +E++ R+ +  Y
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

48) CDR20291_1793 in NC_013316


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  418 bits (1573),  Expect = 5e-118, Method: Compositional matrix adjust.
 Identities = 269/582 (47%), Positives = 387/582 (67%), Gaps = 19/582 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPSDYKYEVAKATKKQFNILKKLMNDKEVDTVINACDAGREGESIFRLVYNQVNC  121
             DLPI+P   +Y V+   K+QF++L  LM+  +V  ++ A DAGREGE IFR+VY+   C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNLTDGKDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            +K   RLWISSMEDSAIK+GF +L  G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANYQKEKYYTVELSMNGFTLSTDRIDDEVAAEQLISL  241
            +N +VGRVQTPTL M+V RD  I++++KEKY  V+++  G    + R+ D   A+ + + 
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDVIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYTQSLYEKKLITYP  300
             +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDY+Q+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKVVFNSKKVTDHHAIIPTISSV  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   V
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  KEDVSELPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGFsk  412
            K++ + L+ SE K+  LI  K+  +V+ P I ++     +  G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  413  ylkeykskkseDA--------VLPDVSVGDVLSVENKEVKEKFTQPPKHFTEDTLLKSME  464
              + ++S    DA         LP++  G+ ++     V E FT PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNDALEKGVEVERKGLGTPATRAGIIENLIFKRFVERDKKNLIATHKGISLVTIVADT  524
             AG + +    + ERKGLGTPATRA+I+E+L+   FV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIKEAVLTY  566
            + S++ TA WE  L++IA+G++   EF+D+IE + +E V TY
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

49) SIR_0986 in NC_022246


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  417 bits (1570),  Expect = 1e-117, Method: Compositional matrix adjust.
 Identities = 266/562 (48%), Positives = 381/562 (68%), Gaps = 19/562 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYTKWNI  61
            KLVIAEKPSVA SIA VIGA  K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   TDLPIVPKNYKYEIAKSTRKQFNILKKLMNDKEIDMVINACDAGREGESIFRLVYNEAKC  121
             DLPI+P   +Y ++   ++QF++L  LM+  ++  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNLKDGKDYDNLFESAQARAIADWLVGMNISRLYSCLYQ  181
            +K   RLWISSMEDSAIK+GF +LK G DYD L++SA  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYAVELATNGFTLSTDRIDDEVAAEQLLNL  241
            +N +VGRVQTPTL M+V RD  I++FKKEKY  V++++ G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDIIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYTQSLYEKKLITYP  300
             +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDY+Q+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKVVFNSKKVTDHHAIIPTISSV  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   V
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  KEDISELPLSEAKVYRLISNKLHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGF--  410
            K++++ L+ SE K+  LI  KL  +V+ P I ++     +  G EFT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  411  --SKYLKEYKSKKNEDI----ELPDVKVGDVISIDNKNIKEKFTQPPKHFTEDTLLKSME  464
               ++    K+  +ED     ELP++  G+ ++    ++ E FT PPK +TEDTLL +ME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNEALEKGVEVERKGLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVSDT  524
             AG E +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELTEIAQGKS  546
            + S++ TA WE  LTEIA+G++
Sbjct  542  LTSPQLTAEWENRLTEIAKGQA  563

50) SANR_1853 in NC_022239


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  412 bits (1550),  Expect = 3e-116, Method: Compositional matrix adjust.
 Identities = 262/568 (47%), Positives = 377/568 (67%), Gaps = 19/568 (3%)

Query  2    KLVIAEKPSVAISIAKVIGANKKKDGYYEGNEYKVSWCVGHLIQMANPDSYDEKYAKWNM  61
            KLVIAEKPSVA SIA VIGA  K DGY EGN Y VSWC+GHL+  A+++ YDE++ KW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ADLPIIPREYKYEVAKATKKQFNILKKLMNDKEIDMVINACDAGREGEAIFRLVYNEAKC  121
             DLPI+P   +Y V+   K+QF++L  LM+  ++  ++ A DAGREGE IFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIKEGFDNLKDGKDYDNLFESSQARAIADWLVGMNISRLYSCLYQ  181
            +K   RLWISSMEDSAIK+GF +LK G DYD L++S+  RA ADWL+G+N +RL+S LY+
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEIANFQQDKYYIVELSMNGFTLSTDRIDDEVTTEQLINL  241
            +N +VGRVQTPTL M+V RD  I++F+++KY IV+++  G    + R+ D   ++ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VDDKIEITDIIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
                  +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMIVST---VNNILGKNDFD-----TERIKVVFNSKKVTDHHAIIPTISSV  352
            RTDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   V
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  KEDVSELPLSEAKVYFLISDKFHASVGYPLVESATKIVAEFDGFEFTSSGKVIVDEG---  409
            K++ + L+ SE K+  LI  K+  +V+ P +  A        G EFT+ GK ++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  410  ----FTKCLK-EYKAKKDENTELPDVSIGDVLSIENKEIKEKFTQPLKHFTEDTLLKAME  464
                F   LK +     +   ELP++  G+ ++     + E FT P K +TEDTLL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  IAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVADS  524
             AG + +    + ERKGLGTPATRA+I+E+L+  GFV+R  K+LI+T  GI+L  +++++
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAETTAKWEMELSDIAKGKENKEDFL  552
            + S++ TA WE  L++IAKG+ + ++F+
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFM  569

51) Dtox_2001 in NC_013216


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  411 bits (1548),  Expect = 7e-116, Method: Compositional matrix adjust.
 Identities = 265/642 (42%), Positives = 395/642 (62%), Gaps = 30/642 (4%)

Query  4    LVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWRTE  63
            LV+AEKPSVAR IA ++  T K  GYLEGN Y+V+W +GHLV++A++  YDE++K WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQARCQ  123
            DLP+LP   + +V      QF+++  LM+RPDV  L+ ATDAGREGEL+ R + + A CQ
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVTRALTVKYNA  183
            KPF RLWISS+ D AI++GF++L+PG +Y+ LY+SA+CRA ADWLIG+N TR ++V Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGKFQAEWRDKSGKHNRFSDCLQA  243
            +L+ GRVQTPTL MLV R+  I  F    +  V    G       +  +  +RFSD  +A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAG-------GADAVSSRFSDAAEA  237

Query  244  ETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRDANKKFGYTAQKTLAGLQMLYER  303
            +T+        +  + +  + K+EQPP  YDLT LQR+AN+ FGYTA++TL   Q LY +
Sbjct  238  NTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK  297

Query  304  HKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFAELVKPLTAKPLPINKRLVDNSKVTD  363
             KL+TYPRTDS+YLT DM+P++ + + ++    +  + K L     P   R++++ KV+D
Sbjct  298  -KLLTYPRTDSQYLTDDMLPAVESLVSGLWE--LVPFAKGLNLS--PQFDRILNSKKVSD  352

Query  364  HHAIIPTTE--RANLAALTAEEKNIYDLIVRRFIAVFYPAYSYKQTTVIVLIAGEHFHAS  421
            HHAIIPT+E  +  +++L+  EK++  LI  +++     +  Y   T     AG++F A 
Sbjct  353  HHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAK  412

Query  422  GKVVTNPGWKAV---YNNESREKDTGYDDTPEQNLPPLKKGDKVKVLSCKSVKGQTKPPA  478
            GK V +PGWK +   + +  +      D  + ++LP L  G+    ++       T PP 
Sbjct  413  GKTVLSPGWKEIERRFRSSLKTDADE-DAEAVRELPELCEGQTFADVAASVTEHFTTPPK  471

Query  479  RYTEASLLSAMEHPGKFIEDEILKESVKESGLGTPATRAEIIEKIISSNYVERRGKELIP  538
             YTE +LLSAME++G     E + E     GLGTPATRA I+EK++   +V+R+GK+LIP
Sbjct  472  PYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIP  527

Query  539  TAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRTKFISGIREHAEKIVTT----V  594
            T  GI+L  ++P  L  ++LTA WE++L +IA G++    F+ GI  +A  +V T     
Sbjct  528  TKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCIS  587

Query  595  LNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSC  636
             +    F+++ V    CP+C   +   K     N  C +R+C
Sbjct  588  EEKQKLFQAERVPIGTCPRCGEAVYEGKK----NYYCGNRAC  625

52) SAIL_7480 in NC_021507


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  402 bits (1511),  Expect = 4e-113, Method: Compositional matrix adjust.
 Identities = 253/583 (44%), Positives = 380/583 (66%), Gaps = 20/583 (3%)

Query  2    KLVIAEKPSVAVTIAKVIGARTRKNGYYEGGGYIVSWCVGHLIQMASPERHDEKWKKWSI  61
            KLVIAEKPSVA +IA VIGA  + +GY EG GY+VSWC+GHL+  A + R DE+ KKW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ENLPIIPEEYIYEVSKSTKKQYGILKKLLNDKNIDTVINACDAGREGELIFRLVYNQAKC  121
            E+LPI+PE   Y V+   K+Q+++L  L++  ++  ++ A DAGREGELIFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKIKRLWISSMENKAIEDGFRNLKEGENFEDLYRSASARAIADWLVGMNLSRLYSCIYK  181
            +K + RLWISSME+ AI DGF +LK G +++ LY+SA  RA ADWL+G+N +RL+S +Y 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  ETYSVGRVQTPTLYLIAKRDSEINLFKKKKYYTVDLSYKGLKLVSDRIDRIEVAEQLLNL  241
               +VGRVQTPTL ++  RD+ I  FKK KY  V+++  G   VS R+     A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  -LEDEIVITEVEDKEISTKPDKPYDLTTLQREANKYFGYSANDTLNLAQALYEKKLITYP  300
                + V   V     + +P K YDLTTLQREAN+ FGY+A++TL+ AQALY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRYLTDDMVTTMKELLEGL------EEDFKINESNFKSIFNSSKVTDHYAIIPTISG  354
            RTDS+YLTDDM+ ++  L+ GL        +++++ ++F  I+NS KV+DH AIIPT   
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLS-PQFDRILNSKKVSDHHAIIPTAEF  362

Query  355  IGKA-KDLTDKESKIYNLIKDKLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEG--  411
            + ++   L++ E K+ +LI  KLL + ++     +    +     +F A GKT++  G  
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  412  -----YTKYLKSYGKEKQK--KELPDIKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKTM  464
                 +   LK+ + E     +ELP++  G+ +   + +++E FT +P  Y EDTLL +M
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  465  ENAGVESLDKAIEVERKGLGTPATRAGIIENLIHKDLIRRDKKNLLVTEKGNRLVSIVED  524
            E AG E  D + + ERKGLGTPATRA+I+E+L++ ++++R  K+L+ T  G  L  ++ +
Sbjct  483  ERAGAE--DMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540

Query  525  KFKSAETTSEWEMKLAKISSGEVDKEDFLREIEDSIKELVDRY  567
             + S++ T+EWE +L+ I+ G+ D ++F+  IE   +ELV+ Y
Sbjct  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

53) Swol_0497 in NC_008346


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  396 bits (1491),  Expect = 2e-111, Method: Compositional matrix adjust.
 Identities = 262/645 (41%), Positives = 408/645 (64%), Gaps = 33/645 (5%)

Query  4    LVLAEKPSVAREIARVLQCSKKSKGYIEGPRYVVTWALGHLVTLAEPDDYDKRLKQWRIE  63
            LV+AEKPSVAR IA V+  + K  GY+EG  Y+V+W +GHLV++A+++ YD R+K+WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPMLPEKMKLKVIKQTSHQFQVVKELMKRNDIEELVIATDAGREGELVARWIMEMVRWR  123
            DLP+LPE  +  V  +  +QF+V+  LM+R D+  LV ATDAGREGEL+ R + +M   +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFKRLWISSQTDNAIREGFARLQPGTQYNSLYAAAACRAEADWLIGLNVTRSLSCKFNA  183
            KPF RLWISS  D+AI++GFA+L+PG +Y++LY +A CRA ADWLIG+N TR +S  ++ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLNAGRVQTPTLAMIVKREKEIKAFVPRDYWTIRADFGDYYGDWRGKDGGRIFDYARAEE  243
            +L  GRVQTPTL M+V R+  I  F    Y  ++   G+      +  ++R+ D A A+ 
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG-----ADAVSSRFSDAAEANT  239

Query  244  ILSRIKGRMAAIKEVKTEARSEAPPLAYDLTELQREANRRLGWSAQKTLSILQELYEVHK  303
            + +      A    V  E ++E PP  YDLT LQREANR +G +A++TL   Q LY + K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LKK  298

Query  304  LVTYPRTDSRYITDDIVPTLPLRLKSM-GVGPYA---DLAHPLLQKPLKPGKRLVDNSKV  359
            L+TYPRTDS+Y+TDD++P++   + ++  + P+A   +L+  +         R++++ KV
Sbjct  299  LLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQF--------DRILNSKKV  350

Query  360  SDHHAIIPTEQPLQ--LKSLNEEERRLYDLIARRFLAVLYPPYRYEQTTIITVVEGENFH  417
            SDHHAIIPT + ++  + +L E E++L  LI  ++L  +  P  YE  T      G++F 
Sbjct  351  SDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFT  410

Query  418  SRGKVEIDRGWRAVQA--VPSDKDEKDEEQLPEQTLARHKKGETLEVKSGKASKHKTKAP  475
            ++GK  +  GW+ ++    +S K + DE+  + + L+    G+T+   ++  + H T +P
Sbjct  411  AKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPP  470

Query  476  ARYTEATLLTAMENCGKLVEDKKLRESIKGSGLGTPATRAEIIEKLIRTSYIERQRKELV  535
              YTE TLL+AME  G       + E     GLGTPATRA I+EKL++ ++++R+ K+L+
Sbjct  471  KPYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLI  526

Query  536  PTSKGIQLMDLAPPDLRSPELTAQWEQRLAEIARGQGKRLDFMADIRRDTVQLVQN---I  592
            PT  GI+L  + P  L SP+LTA+WE+RL+EIA+GQ+   +FM +I  ++ +LVQ    I
Sbjct  527  PTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCI  586

Query  593  KSDSSSTYRADNVSKSKCPQCGRFMLLVNGRKGKILACPERSCGY  637
              +    ++A+ V+ + CP+CG    + +G+K     C +R+C +
Sbjct  587  SEEKQKLFQAERVPIGTCPRCGE--AVYEGKKN--YYCGNRACQF  627

54) SPAP_0887 in NC_014494


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  395 bits (1484),  Expect = 6e-111, Method: Compositional matrix adjust.
 Identities = 254/582 (44%), Positives = 378/582 (65%), Gaps = 18/582 (3%)

Query  2    KLVIAEKPSVAVTIAKVIGARTRKNGYYEGGGYIVSWCVGHLIQMARPDKIDEKWKKWAI  61
            KLVIAEKPSVA +IA VIGA  + +GY EG GY+VSWC+GHL+  A +++ DE+ KKW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DTLPIIPEEYIYEVSKSTKKQYGVLKTLLNDKNIDTVINACDAGREGELIFRLVYNQAKC  121
            + LPI+PE   Y V+   K+Q++VL +L++  ++  ++ A DAGREGELIFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKIQRLWISSMENKAIEDGFRNLKDGENFEDLYRSASARAIADWLVGMNLSRLYSCIYK  181
            +K ++RLWISSME+ AI DGF +LK G +++ LY+SA  RA ADWL+G+N +RL+S +Y 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  ETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYGGLKLVSDRIDRIEVAEQLLNL  241
               +VGRVQTPTL ++  RD+ I  FKK+KY  V+++ GG   VS R+     A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  -LEDEIVITEVEDKEISTKPDKPYDLTTLQREANKYFGYSANDTLNLAQGLYEKKLITYP  300
                + V   V     + +P K YDLTTLQREAN+ FGY+A++TL+ AQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRYLTNDMVTTMKelleg--leegFKIN---ESNFKSIFNSSKVTDHYAIIPTISGI  355
            RTDS+YLT+DM+ ++  L+ G      F       ++F  I+NS KV+DH AIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  356  GKA-KDLSDKESKIYNLIKDKLLASCSDNLKESSRKIRYKYDKFNFSASGKTIIDEG---  411
             ++   L++ E K+ +LI  KLL + ++     +    +     +F+A GKT++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ----YAKYLKPYGKERQEN--ELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAME  465
                +   LK  + E  E   ELP++  G+ +   + +++E FT +P  Y EDTLL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  466  NAGVESLDKDIEVERKGLGTPATRAGIIENLIHKDLIRRDKKNLLVTEKGNRLVSIVEDK  525
             AG E +  D   ERKGLGTPATRA+I+E+L++ ++++R  K+L+ T  G  L  ++ + 
Sbjct  484  RAGAEDMPED--AERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  526  FKSAETTSEWEMKLAKISSGEVDKEDFLREIEDSIRELVDRY  567
            + S++ T+EWE +L+ I+ G+ D ++F+  IE   RELV+ Y
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

55) HMPREF0389_00657 in NC_016630


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  392 bits (1476),  Expect = 2e-110, Method: Compositional matrix adjust.
 Identities = 267/580 (47%), Positives = 384/580 (67%), Gaps = 19/580 (3%)

Query  2    KLVIAEKPSVALSISKIIGAKNKKDGYYEGNGYRVSWCVGHLIQMANPDSYDEKYAKWKI  61
            KLVIAEKPSVA SI+ +IGA +K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW+ 
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   DDLPIIPSEYQYEVAKATKKQFAVLKKLMNDKAIDTVINACDAGREGEAIFRLVYLQASC  121
            +DLPI+P   QY V+   K+QF VL  LM+   +  ++ A DAGREGE IFR+VY  A+C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKMKRLWISSMEDSAIkdgfdklkdgkdydNLFESAQARAVADWLVGMNISRLYSCLYK  181
            +K   RLWISSMEDSAIKDGF  LK G DYD L++SA  RA ADWL+G+N +RL+S LY 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  QNYSVGRVQTPTLAMIVKRDDEITNFKKDKYYTVELSMNGFILSTERIDDEVAAEQLINL  241
            +N +VGRVQTPTL M+V RD  IT+FKK+KY  V+++  G    + R+ D   A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  VGDKIEITDVIQKEKIT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYP  300
             +    +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRCLTEDMITST---VNNILGKNDFDTG-----RIKTVFNSKKVTDHHAIIPTVSSL  352
            RTDS+ LT+DM+ +    V+ +     F  G     ++  ++NSKKV+DHHAIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  353  SEDLSGIPESEAKVYRLISNKLHASVGYPLVENTTKIVAEFDGFQFTSTGKVIKDEGFT-  411
             ++++ ++ESE K+  LI  KL  +V+ P + ++        G +FT+ GK +   G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ---KYLKEYKFNKNEDL----ELPDVSIGDViiienkeikekYTKPPKHFTEDTLLKAME  464
               ++    K + +ED     ELP++  G+ +      + E +T PPK +TEDTLL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  465  LAGNDALEKGVEVEREGLGTPATRAGIIENLIYKEFIERDKKNLIATPKGKSLIEIVVDN  524
             AG + +    + ER GLGTPATRA+I+E+L+   F++R  K+LI+T  G +L  ++ + 
Sbjct  484  RAGAEDMPE--DAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  525  FKSAEMTAQWEMELSEIAQGKSSKKEFLEKIEEQIKHTVE  564
            + S+++TA+WE  L+EIA+G++   EF++ IE Q ++ V+
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQ  581

56) DHBDCA_p643 in NC_018866


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  392 bits (1476),  Expect = 3e-110, Method: Compositional matrix adjust.
 Identities = 259/642 (41%), Positives = 404/642 (63%), Gaps = 32/642 (4%)

Query  4    LILAEKPSVAREIARVLKCNIKNKGFIEGPQYVVTWALGHLVTLAEPEDYDQKYKEWRME  63
            L++AEKPSVAR IA V+    K+ G++EG  Y+V+W +GHLV++A++  YD+++K WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPMLPEQLKLKVIRQTSQQYQTVNKLMKRNDINELIIATDAGREGELVARWIMRLSNWK  123
            DLP+LPE  +  V  +  QQ++ +  LM+R D+  L+ ATDAGREGEL+ R + +++  +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFKRLWISSQTDAAILEGFARLKPGPEYNDLYDAAVCRAEADWLIGLNVTRALTCKYNA  183
            KPF RLWISS  D+AI +GFA+LKPG +Y+ LY++A+CRA ADWLIG+N TR ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLNSGRVQTPTLAMIVQREDEIRKFVPVDYWTIRADFGDFFADWRGKDGSRIYDYQQVEA  243
            +L  GRVQTPTL M+V+R+  I  F    Y  ++   G+      +  +SR+ D  + ++
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG-----ADAVSSRFSDAAEANT  239

Query  244  LLGKLEKQSARIMQVKRESKSEPAPLAYDLTELQRDANRKLSFSAQKTSSTLQNLYERHK  303
            + +   K  A  + V RE K+E +P  YDLT LQR+ANR ++++A++T    Q LY + K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK-K  298

Query  304  LVTYPRTDSRYLSADIVPTLPSRLKGL-AAGPYAETAKKLLAQPYKPTKRLVDDSKVTDH  362
            L+TYPRTDS+YL+ D++P++ S + GL    P+A   +  L+  +    R+++  KV+DH
Sbjct  299  LLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLN--LSPQF---DRILNSKKVSDH  353

Query  363  HAIIPTEQPLK--LGDLTHDEKSLYDLIVRRFLAVLSPPYRYDQLTVIAGINGEMFYAAG  420
            HAIIPT + +K  +G L++ EK L  LI  ++L  ++ P  Y+ +T      G+ F A G
Sbjct  354  HAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKG  413

Query  421  KVMKDQGWRSITS--HQTEPEESREDALPEQTLGKLEQSEERMLKSLKPQKGK--TKPPA  476
            K +   GW+ I    + +   ++ EDA + + L  L   E + +  + +      T PP 
Sbjct  414  KTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPEL--CEGQTFADVAASVTEHFTTPPK  471

Query  477  RYTEATLLTAMENPGKFIEDEELRETMKGSGLGTPATRAEIIEKLLHTSYIERSGKELVP  536
             YTE TLL+AME +G     E++ E     GLGTPATRA I+EKL++ ++++R GK+L+P
Sbjct  472  PYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIP  527

Query  537  TSKGRQLISLVAPELRSPELTAQWEQALTDIAKGNGSKTEFIKGIRTKASELVHSVASDS  596
            T  G +L  +++  L SP+LTA+WE+ LT+IAKG++   EF+ GI T+A ELV++ +  S
Sbjct  528  TKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCIS  587

Query  597  AT----YHADNMTKTRCPVCKKYMLLVNGKRGKMLVCQDRAC  634
                  ++A+ +    CP C     + +GK+     C +RAC
Sbjct  588  EEKQKLFQAERVPIGTCPRCGE--AVYEGKKN--YYCGNRAC  625

57) DCF50_p701 in NC_018867


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  392 bits (1476),  Expect = 3e-110, Method: Compositional matrix adjust.
 Identities = 259/642 (41%), Positives = 404/642 (63%), Gaps = 32/642 (4%)

Query  4    LILAEKPSVAREIARVLKCNIKNKGFIEGPQYVVTWALGHLVTLAEPEDYDQKYKEWRME  63
            L++AEKPSVAR IA V+    K+ G++EG  Y+V+W +GHLV++A++  YD+++K WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPMLPEQLKLKVIRQTSQQYQTVNKLMKRNDINELIIATDAGREGELVARWIMRLSNWK  123
            DLP+LPE  +  V  +  QQ++ +  LM+R D+  L+ ATDAGREGEL+ R + +++  +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFKRLWISSQTDAAILEGFARLKPGPEYNDLYDAAVCRAEADWLIGLNVTRALTCKYNA  183
            KPF RLWISS  D+AI +GFA+LKPG +Y+ LY++A+CRA ADWLIG+N TR ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLNSGRVQTPTLAMIVQREDEIRKFVPVDYWTIRADFGDFFADWRGKDGSRIYDYQQVEA  243
            +L  GRVQTPTL M+V+R+  I  F    Y  ++   G+      +  +SR+ D  + ++
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG-----ADAVSSRFSDAAEANT  239

Query  244  LLGKLEKQSARIMQVKRESKSEPAPLAYDLTELQRDANRKLSFSAQKTSSTLQNLYERHK  303
            + +   K  A  + V RE K+E +P  YDLT LQR+ANR ++++A++T    Q LY + K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLK-K  298

Query  304  LVTYPRTDSRYLSADIVPTLPSRLKGL-AAGPYAETAKKLLAQPYKPTKRLVDDSKVTDH  362
            L+TYPRTDS+YL+ D++P++ S + GL    P+A   +  L+  +    R+++  KV+DH
Sbjct  299  LLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLN--LSPQF---DRILNSKKVSDH  353

Query  363  HAIIPTEQPLK--LGDLTHDEKSLYDLIVRRFLAVLSPPYRYDQLTVIAGINGEMFYAAG  420
            HAIIPT + +K  +G L++ EK L  LI  ++L  ++ P  Y+ +T      G+ F A G
Sbjct  354  HAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKG  413

Query  421  KVMKDQGWRSITS--HQTEPEESREDALPEQTLGKLEQSEERMLKSLKPQKGK--TKPPA  476
            K +   GW+ I    + +   ++ EDA + + L  L   E + +  + +      T PP 
Sbjct  414  KTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPEL--CEGQTFADVAASVTEHFTTPPK  471

Query  477  RYTEATLLTAMENPGKFIEDEELRETMKGSGLGTPATRAEIIEKLLHTSYIERSGKELVP  536
             YTE TLL+AME +G     E++ E     GLGTPATRA I+EKL++ ++++R GK+L+P
Sbjct  472  PYTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIP  527

Query  537  TSKGRQLISLVAPELRSPELTAQWEQALTDIAKGNGSKTEFIKGIRTKASELVHSVASDS  596
            T  G +L  +++  L SP+LTA+WE+ LT+IAKG++   EF+ GI T+A ELV++ +  S
Sbjct  528  TKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCIS  587

Query  597  AT----YHADNMTKTRCPVCKKYMLLVNGKRGKMLVCQDRAC  634
                  ++A+ +    CP C     + +GK+     C +RAC
Sbjct  588  EEKQKLFQAERVPIGTCPRCGE--AVYEGKKN--YYCGNRAC  625

58) MGAS10750_Spy1696 in NC_008024


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  390 bits (1465),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 258/582 (45%), Positives = 377/582 (65%), Gaps = 18/582 (3%)

Query  6    KLVIAEKPSVAVTIAKIIGARTRKNGYYEGNGYIVSWCVGHLIQMASPDKIDEKWKKWTI  65
            KLVIAEKPSVA +IA +IGA  + +GY EGNGY+VSWC+GHL+  A +++ DE+ KKW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  66   ENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNINIVINACDAGREGELIFRLVYNQAKC  125
            E+LPI+PE   Y V+   K+Q++VL  L++  ++  ++ A DAGREGELIFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  126  KKKIQRLWISSMENEAIEDGFRNLKDGEKFEDLYRSASARAIADWLVGMNLSRLYSCIYK  185
            +K ++RLWISSME+ AI DGF +LK G  ++ LY+SA  RA ADWL+G+N +RL+S +Y 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  186  ETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYGGLKLVSDRIDRIEVAEQLLNL  245
               +VGRVQTPTL ++  RD+ I  FKK+KY  V+++ GG   VS R+     A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  246  -LEDEIVITEVEDKEVSTKPDKPYDLTTLQREANKYFGYSANDTLNLAQALYEKKLITYP  304
                + V   V     + +P K YDLTTLQREAN+ FGY+A++TL+ AQALY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  305  RTDSRYLTDDMVNTMKELLEGLEE-----DfklnksnfksifnsskVTDHYAIIPTISGI  359
            RTDS+YLTDDM+ ++  L+ GL E           ++F  I+NS KV+DH AIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  360  GKA-KDLSDKESKVYNLIKDKLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEG---  415
             ++   L++ E K+ +LI  KLL + ++     +    +     +F A GKT++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  416  ----YTKYLKAYGKEKQEN--ELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAME  469
                +   LK+ + E  E   ELP++  G+ +   + +++E FT +P  Y EDTLL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  470  NAGVESLDKDIEVERKGLGTPATRAGIIENLIHKELIRRDKKNLLVTEKGNRLVSIVEDK  529
             AG E +  D   ERKGLGTPATRA+I+E+L++  +++R  K+L+ T  G  L  ++ + 
Sbjct  484  RAGAEDMPED--AERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  530  FKSAETTSEWEMKLAKINSGEVDKEDFLREIEDSIRELVDRY  571
            + S++ T+EWE +L+ I  G+ D ++F+  IE   RELV+ Y
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

59) FMG_0956 in NC_010376


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  388 bits (1459),  Expect = 6e-109, Method: Compositional matrix adjust.
 Identities = 257/582 (45%), Positives = 374/582 (65%), Gaps = 18/582 (3%)

Query  2    KLVIAEKPSVAVTIAKVIGARTRKNGYYEGNGYIVSWCVGHLIQMASPERHDEKWKKWTI  61
            KLVIAEKPSVA +IA VIGA  + +GY EGNGY+VSWC+GHL+  A + R DE+ KKW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNIDTVINACDAGREGELIFRLVYNQAKC  121
            E+LPI+PE   Y V+   K+Q++VL  L++  ++  ++ A DAGREGELIFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKIQRLWISSMENKAIEDGFRNLKDGEKFEDLYGSASARAIADWLVGMNLSRLYSCIYK  181
            +K ++RLWISSME+ AI DGF +LK G  ++ LY SA  RA ADWL+G+N +RL+S +Y 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  ETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYKGLKLVSDRIDKIEVAEQLLNL  241
               +VGRVQTPTL ++  RD+ I  FKK+KY  V+++  G   VS R+     A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  iedeivitevedkeiST-KPDKPYDLTTLQREANKYFGYSANDTLNMAQGLYEKKLITYP  300
                  +     +E  T +P K YDLTTLQREAN+ FGY+A++TL+ AQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRYLTDDMVTTMKelleg--leegFKIN---ESNFKSIFNSSKVTDHYAIIPTISGI  355
            RTDS+YLTDDM+ ++  L+ G      F       ++F  I+NS KV+DH AIIPT   +
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFV  363

Query  356  GKV-KDLSDKESKVYNLIKDKLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEG---  411
             +    L++ E K+ +LI  KLL + ++     +    +     +F A GKT++  G   
Sbjct  364  KQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKE  423

Query  412  ----YTKYLKAYGKEKQEN--ELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAME  465
                +   LK+ + E  E   ELP++  G+ +   + +++E FT +P  Y EDTLL AME
Sbjct  424  IERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAME  483

Query  466  NAGIESLDKDIEVERKGLGTPATRAGIIENLIHKDLIRRDKKNLLVTEKGNRLVSIVEDK  525
             AG E +  D   ERKGLGTPATRA+I+E+L++ ++++R  K+L+ T  G  L  ++ + 
Sbjct  484  RAGAEDMPED--AERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEA  541

Query  526  FKSAKTTSEWEMKLAKISSGEVDKEDFLREIEDSIRELVDRY  567
            + S++ T+EWE +L+ I+ G+ D ++F+  IE   RELV+ Y
Sbjct  542  LTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

60) Apre_1822 in NC_013164


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  387 bits (1456),  Expect = 9e-109, Method: Compositional matrix adjust.
 Identities = 254/583 (44%), Positives = 379/583 (66%), Gaps = 20/583 (3%)

Query  2    KLVIAEKPSVAVTIAKVIGARTRKNGYYEGGGYIVSWCVGHLIQMASPDKIDEKWKKWTI  61
            KLVIAEKPSVA +IA VIGA  + +GY EG GY+VSWC+GHL+  A +++ DE+ KKW  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNIDTVINACDAGREGELIFRLVYNQAKC  121
            E+LPI+PE   Y V+   K+Q++VL  L++  ++  ++ A DAGREGELIFR+VY+ A C
Sbjct  64   EDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGC  123

Query  122  KKKIQRLWISSMENKAIEDGFRNLKDGENFEDLYRSASARAIVDWLVGMNLSRLYSCIYK  181
            +K ++RLWISSME+ AI DGF +LK G +++ LY+SA  RA  DWL+G+N +RL+S +Y 
Sbjct  124  QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYH  183

Query  182  ETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYGGLKLVSDRIDKIEVAEQLLNL  241
               +VGRVQTPTL ++  RD+ I  FKK+KY  V+++ GG   VS R+     A+ +   
Sbjct  184  KNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAA  243

Query  242  -LEDEIVITEVEDKEISTRPDKPYDLTTLQREANKYFGYSANDTLNLAQGLYEKKLITYP  300
                + V   V     + +P K YDLTTLQREAN+ FGY+A++TL+ AQ+LY KKL+TYP
Sbjct  244  CAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYP  303

Query  301  RTDSRHLTDDMVNTMKELLEG------FEEDFKINESNFKSIFNSSKVTDHYAIIPTISG  354
            RTDS+ LTDDM+ ++  L+ G      F  +++++ ++F  I+NS KV+DH AIIPT   
Sbjct  304  RTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLS-PQFDRILNSKKVSDHHAIIPTAEF  362

Query  355  IGKA-KDLSDKESKIYNLIKNKLLASCSDNLKESSRKIRYEYDKFNFNASGKTVIDEG--  411
            + ++   L++ E K+ +LI  KLL + ++     +    +     +F A GKTV+  G  
Sbjct  363  VKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWK  422

Query  412  -----YTKYLKPYGKERQEN--ELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAM  464
                 +   LK  + E  E   ELP++  G+ +   + +++E FT +P  Y EDTLL AM
Sbjct  423  EIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAM  482

Query  465  ENAGIKSLDKDIEVERKGLGTPATRAGIIENLIHkdlirrdkkkllVTEKGNRLVSIVED  524
            E AG   +  D   ERKGLGTPATRA+I+E+L++ ++++R  K+L+ T  G  L  ++ +
Sbjct  483  ERAGAEDMPED--AERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE  540

Query  525  KFKSAETTSEWEMKLAKISSGEVDKEDFLREIEDSIRELVDRY  567
             + S++ T+EWE +L+ I+ G+ D ++F+  IE   RELV+ Y
Sbjct  541  ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTY  583

61) SIR_1325 in NC_022246


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  383 bits (1440),  Expect = 2e-107, Method: Compositional matrix adjust.
 Identities = 265/579 (46%), Positives = 381/579 (66%), Gaps = 19/579 (3%)

Query  3    LVIAEKPSVALSIAKVIGAKNKKDGYYEGNGYRVSWCVGHLIQMANPDSYDEKYAKWNID  62
            LVIAEKPSVA SIA VIGA +K DGY EGNGY VSWC+GHL+  A+++ YDE++ KW  +
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  63   DLPIIPSEYQYEVAKATKKQFNTLKKLMNDKEIDTVINACDAGQEGEAIFRLVYLQANCK  122
            DLPI+P   QY V+   K+QF+ L  LM+  ++  ++ A DAG+EGE IFR+VY  A C+
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  123  KKMKRLWISSMEDSAIkdgfdklkdgkdydNLFESAQARAIADWLVGMNISRLYSCLYKQ  182
            K   RLWISSMEDSAIKDGF  LK G DYD L++SA  RA ADWL+G+N +RL+S LY +
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  183  NYSVGRVQTPTLSMIVKRDDEIANFKKEKYYTVELELDGFTLSTERIDSLEVAEQLKNLL  242
            N +VGRVQTPTL M+V RD  I++FKKEKY  V++  +G    + R+     A+ +K   
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTVKAAC  244

Query  243  ENRIEITDVIQKEKVT-KPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPR  301
             +   +   + +EK T +P   +DLTTLQRE N+ FGY+AKQTLDYAQ+LY KKL+TYPR
Sbjct  245  AKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLLTYPR  304

Query  302  TDSRCLTEDMITST---VNNILGKNDFD-----TERIKTVFNSKKVTDHHAIIPTVSSLS  353
            TDS+ LT+DM+ +    V+ +     F      + ++  ++NSKKV+DHHAIIPT   + 
Sbjct  305  TDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTAEFVK  364

Query  354  EDISKLPESEAKVYRLISNKFHASVGYSLTQNTTKIVAEFDGFEFTSSGKVIKDEGFsky  413
            ++++ L+ESE K+  LI  K+  +V+ +   ++        G EFT+ GK +   G    
Sbjct  365  QGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPGWKEI  424

Query  414  lkeykskkseDA--------VLPDVSVGDVLTIENKEIKEKFTQPPKHFTEDTLLKAMEL  465
             + ++S    DA         LP++  G+ ++     + E FT PPK +TEDTLL AME 
Sbjct  425  ERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLSAMER  484

Query  466  AGNDAFEKGVEVEREGLGTPATRAGIIENLIYKEFIERDKKNLIATPKGKSLIEIVADNF  525
            AG +  +   + ER GLGTPATRA+I+E+L+   F++R  K+LI+T  G +L  ++++ +
Sbjct  485  AGAE--DMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPEAL  542

Query  526  KSAEMTAQWEMELSEIAQGKSSKKEFLEKIEEQIKHTVE  564
             S+++TA+WE  L+EIA+G++   EF++ IE Q ++ V+
Sbjct  543  TSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQ  581

62) Ccel_0922 in NC_011898


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  381 bits (1433),  Expect = 9e-107, Method: Compositional matrix adjust.
 Identities = 264/649 (41%), Positives = 411/649 (64%), Gaps = 32/649 (4%)

Query  1    MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKT  60
            M + L++AEKPSVAR +A V+   ++ +GY+ G+ Y+V+W +GHLV++AD+  Y++++K 
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMK  120
            W  EDLP+LP+  + +V  +  +Q++V+ +L++R+DV  LV ATD+GREGEL+ R +   
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTC  180
            AG +KP+ RLWISS  D AIK+GFA L+P+ +YD LY SA  RA ADWLIG+N TR ++ 
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  KYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFN  240
             Y+ +L+ GRVQTPTL M+V+R+  I  F+   Y  +     G       +    +R  +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG-------ADAVSSRFSD  233

Query  241  KEEADGIVAKITGQMGevvevkketkkeLPPLAYDLTELQRDANKKFSYSAKQTLNIMQR  300
              EA+ + A  +   +  V V +E K E PP  YDLT LQR+AN+ F+Y+AKQTL+  Q 
Sbjct  234  AAEANTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQA  293

Query  301  LYESHKLVTYPRTDSRYITDDIVPTLNERLKSI-AVGPYAKLVQGVMRNKPSVTKRFVDN  359
            LY   KL+TYPRTDS+Y+TDD++P+++  + ++  + P+AK +     N ++   R++++
Sbjct  294  LY-LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGL-----NLSPQFDRILNS  347

Query  360  SKVTDHHAIIPTEQFV--DLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGE  417
             KV+DHHAIIPT +FV  ++ +L   E+++  LI  +++  ++ P  YE  T  +  AG+
Sbjct  348  KKVSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQ  407

Query  418  SFYAKGKIVKSSGWKTV---YDGFGKLdeddeddndQSLPDIQKGHKAKVVGPKSINGKT  474
             F AKGK V S+GWK +   + +  K D D++ +  + LP++  G+    V++   +  T
Sbjct  408  EFTAKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFT  467

Query  475  KPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKG  534
             PP  YTE TLLSAME++G       + E  E   GLGTPATRA I+EKL +  +++RKG
Sbjct  468  TPPKPYTEDTLLSAMERAG----AEDMPEDAERK-GLGTPATRAAILEKLVQMGFVQRKG  522

Query  535  KEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGA  594
            K++ PT  G +L  ++P  L SP+LTA WE++LT I+KG+ +++ F++++   AR LV +
Sbjct  523  KQLIPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQT  582

Query  595  VIASSEQ----FKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGY  639
                SE+    F+ + V    CP CG  + E  GKK     C +R C +
Sbjct  583  YSCISEEKQKLFQAERVPIGTCPRCGEAVYE--GKKN--YYCGNRACQF  627

63) Sinac_2513 in NC_019892


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  377 bits (1417),  Expect = 2e-105, Method: Compositional matrix adjust.
 Identities = 259/647 (41%), Positives = 400/647 (62%), Gaps = 40/647 (6%)

Query  2    KVVIAEKPSVARELAAFLGAKTRHEGYFEGRGYQVTWALGHLATLKEPHDYDPALKRWSL  61
            K+VIAEKPSVAR +A+ +GA  +H+GY+EG GY V+W +GHL ++ ++  YD  +K+W  
Sbjct  4    KLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRY  63

Query  62   ETLPFVPDRFGLKVIEDRGARKQFEVIRRLFRGAD--ELVCATDAGREGELIFRYILDLA  119
            E LP++P+     V +D+  ++QF+V+  L + +D   LVCATDAGREGELIFR++ ++A
Sbjct  64   EDLPILPETWQYIVPDDK--KQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMA  121

Query  120  GCGTKPSKRLWLSSLTESAIREAFDRLRPLSDYDTLFAAARCRSEADWVVGLNATRYYTV  179
            GC  KP  RLW+SS+ +SAI+++F +L+P +DYD L+ +A CR+ ADW++G+NATR ++V
Sbjct  122  GC-QKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  180  RYRTPGLLWSVGRVQTPVLAMIVRRDDEIRTFKPEPFWEVLTRYREVMFKFTGNRFLKEE  239
             Y+      +VGRVQTP L M+V RD  I  FK E +   + +         ++RF    
Sbjct  181  LYHKN---LTVGRVQTPTLKMLVDRDAKITDFKKEKY--HIVHITAGGADAVSSRFSDAA  235

Query  240  DARALLDRVVGHPFTIQGVDRKPERVPPPQLYDLTDLQRDMNRRYGMSADATLKAAQALY  299
            +A ++            +V R      PP+LYDLT LQR+ NR +G +A  TL  AQALY
Sbjct  236  EANTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY  295

Query  300  EAKLLSYPRTDSRYLGSDMKAKVPAILFDLRDLRPVEIDKLDLKALSFTGRIINDQKVSD  359
              KLL+YPRTDS+YL  DM + V +++ +L++L P   + L+L +  F +RI+N +KVSD
Sbjct  296  LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKG-LNLSP-QF-DRILNSKKVSD  352

Query  360  HHAIIPTGKVP----GDLPPVGRKVFDAVVTRFIAAFYPTCLKEITTVSGVANTVPFRAR  415
            HHAIIPT+       G L+   +K++  +  +++ A     + E  T +       F A+
Sbjct  353  HHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAK  412

Query  416  GVRVVDPGWTVLYPR-------NQDEKKDEEQELPEFRSGES-GPHEPSVKRGETTPPKS  467
            G  V+ PGW  +  R       + DE  +  +ELPE+  G++ +   +SV    TTPPK+
Sbjct  413  GKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKP  472

Query  468  YTEGTLLGAMETAGRFVDDEELKEALKERGLGTPATRASIIETLLARGYITREKKTVAAT  527
            YTE+TLL+AME AG     E++ E    +GLGTPATRA+I+E L+  G++ R  K + +T
Sbjct  473  YTEDTLLSAMERAG----AEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPT  528

Query  528  DLGRYLIALIQIRGLKSPELTGEWEAKLREIERGRLDAQTFMGEIAHYTDEVIRSGDETA  587
              G  L  ++   +L SP+LT+EWE +L EI +G+ D++ FM+ I   + E++++    +
Sbjct  529  KDGINLAVVLP-EALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCIS  587

Query  588  VDPDRL--------GDCPRCGRPVIAGKKGYGCSGWREGCKFVLWRE  626
             + ++L        G CPRCG +V  GKK Y C+ +  +C+FV+W++
Sbjct  588  EEKQKLFQAERVPIGTCPRCGEAVYEGKKNYYCGNR--ACQFVMWKN  632


 Score = 56.3 bits (194),  Expect = 8e-09, Method: Compositional matrix adjust.
 Identities = 26/88 (30%), Positives = 48/88 (55%), Gaps = 7/88 (7%)

Query  722  VSLGPCPLCGSDVFEQDKAYRCAGQKGACRFSLWKK-----IAGKTIGVRAVQALLKQGR  776
            V++G CP CG  V+E  K Y C+ +  AC+F +WK+        K++  +   ALLK G+
Sbjct  599  VPIGTCPRCGEAVYEGKKNYYCGNR--ACQFVMWKNDRFFEERKKAFTPKIAAALLKTGK  656

Query  777  TALIKGFKSKAGKRFEARLKLEEGEVRF  804
              +   +  K+GK +++ + L +   ++
Sbjct  657  VKVKGLYSVKTGKTYDGTVLLADTGGKY  684

64) topB1 in NC_017542


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  376 bits (1412),  Expect = 4e-105, Method: Compositional matrix adjust.
 Identities = 254/619 (42%), Positives = 383/619 (62%), Gaps = 36/619 (5%)

Query  4    LVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYATWNLE  63
            LV+AEKPSVAR IA V+G+ EKH +Y+EG  Y+V+W +GHLV++A++  YD ++  W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPILPKNSKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWK  123
            DLPILP   +  V  + ++QF  +  LM+R D+  L+ ATDA+REGEL+ R + QMA  +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFRRLWISSQTDKAIKAGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTVRYNA  183
            KPF RLWISS  D AIK GFA L PG ++D LY+SA CRA ADW+IG+N TR ++V Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGHFQATWRAENGDSRMFDRTQAE  243
            +L+ GRVQTPTL M+++R+  IT+F+ + Y+ +    G       A+   SR  D ++A+
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG------ADAVSSRFSDAAEAN  238

Query  244  TLRHRLEGAKGTVVSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQH  303
            T++     A++  VSV +  K E  P  YDLT LQR+AN+ +G++AKQT +  Q LY   
Sbjct  239  TVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LK  297

Query  304  KLVTYPRTDSRYLTSDMVDSLKERLSSV-AVGPYASLARPLLRNKLPITKRVVDDSKVTD  362
            KL+TYPRTDS+YLT DM+ ++   +S++  + P+   A+ L  N  P   R+++  KV+D
Sbjct  298  KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGL--NLSPQFDRILNSKKVSD  352

Query  363  HHAIIPTEQTLL--LNQLSPEERKLYDLIARRFISLFYPPARYDAVAVSVMVGQETFQVK  420
            HHAIIPT + +   +  L+  E+KL  LI  +++     P  Y+AV+ +   + + F  K
Sbjct  353  HHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAK  412

Query  421  GTTIKDSGWRAVYDESHYELD-DEEIDDRENNGRGVILPELKKGDSVQLQRCIVRAGRTM  479
            G T+  +GW+ +  E ++      + D+  +  R   LPEL  G++       V    T 
Sbjct  413  GKTVLSPGWKEI--ERRFRSSLKTDADEDAEAVRE--LPELCEGQTFADVAASVTEHFTT  468

Query  480  PPKRYTEAALLAQM------------EKHGLGTPATRADLIEKLVSSDTIERQGNVMHPT  527
            PPK YTE +LL+ M            E+ GLGTPATRA ++EKLV  + ++R+G+ + PT
Sbjct  469  PPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPT  528

Query  528  GKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPEPFLNSIRAMAKELVSTVKNSSA  587
              G +L  + +  L +P+LTA WE  L  IA+GQ++P+ F+++I + A+ELV T    S 
Sbjct  529  KDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISE  588

Query  588  E----YKPHNVTNSHCPDC  602
            E    ++++ V  + CP C
Sbjct  589  EKQKLFQAERVPIGTCPRC  607

65) PPSC2_c0842 in NC_014622


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  376 bits (1412),  Expect = 4e-105, Method: Compositional matrix adjust.
 Identities = 254/619 (42%), Positives = 383/619 (62%), Gaps = 36/619 (5%)

Query  4    LVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYATWNLE  63
            LV+AEKPSVAR IA V+G+ EKH +Y+EG  Y+V+W +GHLV++A++  YD ++  W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPILPKNSKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWK  123
            DLPILP   +  V  + ++QF  +  LM+R D+  L+ ATDA+REGEL+ R + QMA  +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFRRLWISSQTDKAIKAGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTVRYNA  183
            KPF RLWISS  D AIK GFA L PG ++D LY+SA CRA ADW+IG+N TR ++V Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGHFQATWRAENGDSRMFDRTQAE  243
            +L+ GRVQTPTL M+++R+  IT+F+ + Y+ +    G       A+   SR  D ++A+
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG------ADAVSSRFSDAAEAN  238

Query  244  TLRHRLEGAKGTVVSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQH  303
            T++     A++  VSV +  K E  P  YDLT LQR+AN+ +G++AKQT +  Q LY   
Sbjct  239  TVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LK  297

Query  304  KLVTYPRTDSRYLTSDMVDSLKERLSSV-AVGPYASLARPLLRNKLPITKRVVDDSKVTD  362
            KL+TYPRTDS+YLT DM+ ++   +S++  + P+   A+ L  N  P   R+++  KV+D
Sbjct  298  KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGL--NLSPQFDRILNSKKVSD  352

Query  363  HHAIIPTEQTLL--LNQLSPEERKLYDLIARRFISLFYPPARYDAVAVSVMVGQETFQVK  420
            HHAIIPT + +   +  L+  E+KL  LI  +++     P  Y+AV+ +   + + F  K
Sbjct  353  HHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAK  412

Query  421  GTTIKDSGWRAVYDESHYELD-DEEIDDRENNGRGVILPELKKGDSVQLQRCIVRAGRTM  479
            G T+  +GW+ +  E ++      + D+  +  R   LPEL  G++       V    T 
Sbjct  413  GKTVLSPGWKEI--ERRFRSSLKTDADEDAEAVRE--LPELCEGQTFADVAASVTEHFTT  468

Query  480  PPKRYTEAALLAQM------------EKHGLGTPATRADLIEKLVSSDTIERQGNVMHPT  527
            PPK YTE +LL+ M            E+ GLGTPATRA ++EKLV  + ++R+G+ + PT
Sbjct  469  PPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPT  528

Query  528  GKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPEPFLNSIRAMAKELVSTVKNSSA  587
              G +L  + +  L +P+LTA WE  L  IA+GQ++P+ F+++I + A+ELV T    S 
Sbjct  529  KDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISE  588

Query  588  E----YKPHNVTNSHCPDC  602
            E    ++++ V  + CP C
Sbjct  589  EKQKLFQAERVPIGTCPRC  607

66) Clo1100_3206 in NC_016791


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  376 bits (1412),  Expect = 4e-105, Method: Compositional matrix adjust.
 Identities = 260/649 (41%), Positives = 407/649 (63%), Gaps = 31/649 (4%)

Query  1    MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKT  60
            M + LVIAEKPSVAR +A V+   ++ +GY+ G+ Y+V+W +GHLV++AD+  Y++++K 
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMK  120
            W  EDLP+LP+  + +V  +  +Q++V+ +L++R+DV  LV ATD+GREGEL+ R +   
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTC  180
            AG +KP+ RLWISS  D AIK+GFA L+P+ +YD LY SA  RA ADWL+G+N TR ++ 
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  KYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFN  240
             Y+ +L+ GRVQTPTL M+V+R+  I  F+   Y  +     G       + +  +R  +
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG-------ADAVSSRFSD  233

Query  241  KEEADGIVAKITGQIGevvevkketkkeLPPLAYDLTELQRDANKKFSYSAKQTLNIMQR  300
              EA+ + A  +   +  V V +E K E PP  YDLT LQR+AN+ F+Y+AKQTL+  Q 
Sbjct  234  AAEANTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQA  293

Query  301  LYESHKLVTYPRTDSRYITDDIVPTLNERLKSI-AVGPYAKLVQGVMRNKISVTKRFVDN  359
            LY   KL+TYPRTDS+Y+TDD++P+++  + ++  + P+AK ++  +  ++    R++++
Sbjct  294  LY-LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLN--LSPQFD---RILNS  347

Query  360  SKVTDHHAIIPTEQFV--DLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGE  417
             KV+DHHAIIPT +FV  ++++L   E+++  LI  +++  ++ P  YE  T  +  AG+
Sbjct  348  KKVSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQ  407

Query  418  SFYAKGKIVRSSGWKTVYDGFGKldedsdeddndqslpdIQ--KGHKAKVVAPKAINGKT  475
             F AKGK V S+GWK +   F        ++D +      +   G+    VA+   +  T
Sbjct  408  EFTAKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFT  467

Query  476  KPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRG  535
             PP  YTE TLLSAME++G       + E  E   GLGTPATRA I+EKL +  +++R+G
Sbjct  468  TPPKPYTEDTLLSAMERAG----AEDMPEDAERK-GLGTPATRAAILEKLVQMGFVQRKG  522

Query  536  KEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGA  595
            K++ PT  G +L  ++P  L SP+LTA WE++L+ I+KG+A+++ F++ +   A+ LV +
Sbjct  523  KQLIPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQT  582

Query  596  VIASSEQ----FKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGY  640
                SE+    F+ + V    CP CG  + E  GKK     C +R C +
Sbjct  583  YSCISEEKQKLFQAERVPIGTCPRCGEAVYE--GKKN--YYCGNRACQF  627

67) topB in NC_020210


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  375 bits (1409),  Expect = 6e-105, Method: Compositional matrix adjust.
 Identities = 260/649 (41%), Positives = 396/649 (62%), Gaps = 42/649 (6%)

Query  4    LVLAEKPSVARDIARVLGCKETHQSYMEGPRYIVTWALGHLVELKMPEDYDRKYETWRLE  63
            LV+AEKPSVAR IA V+G  E H++Y+EG  Y+V+W +GHLV +  +  YD ++  WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWT  123
            DLPI+P      V  +  +QF  +  L +RPDV +++ ATDAGREGEL+ R + +M G  
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVSRALTTKYND  183
            KP+ RLWISS  D AI+DGF +LKPG+++D LYQSA+CRA ADWLIG+N +R ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  PLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEAKQ  243
             L+ GRVQTPTL M+++R+  I  F    Y  ++   G+  AV     + R+ D  EA+ 
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-----SSRFSDAAEANT  239

Query  244  LLARLDGQPARVVSVKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHK  303
            + A      A  VSV R +K+E +P  YDLT LQR+AN+ FG++AK+TL   Q LY   K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LKK  298

Query  304  LVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLakgkakaakRVFNDDKVTDHH  363
            L+TYPRTDS+YL  DM +++     ++ SG  ++++   +   +    R++N  KV+DHH
Sbjct  299  LLTYPRTDSQYLTDDMLPAVE----SLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHH  354

Query  364  AIVPTDE--RLNLSRLSTDERKLYDLIARRFLALFFPPYESETTTAVFDIGGEMFVAKET  421
            AI+PT E  +  ++ L+  E+KL  LI  ++L     P   E+ TA F  +G+ F AK  
Sbjct  355  AIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGK  414

Query  422  AVVNAG-------FQAVL---SKEDNKAQPTLLHLAEGQTLPSVQLELEQSFTEPPARYS  471
            +V+++G       F++ L   + ED  A   L +L EGQT++ V   + + FT PP  Y+
Sbjct  415  TVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYT  474

Query  472  EADLLAQMEKY------------GLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQL  519
            E  LL+ ME+             GLGTPATRA I+E+LV+   V+RK+ ++ PTK G +L
Sbjct  475  EDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINL  534

Query  520  IELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTQQLVAEIK----QSEQVY  575
              ++ E L SP+LTA WE  L  IA+G+++P++F+  I  Q+++LV        + ++++
Sbjct  535  AVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLF  594

Query  576  KAPNLTNLTCPECGALLKERKTKDGRMLVCSNLQCRYRRRRDPKLSNRR  624
            +A  +   TCP CG  + E K    +   C+N  C++  +++ ++ + R
Sbjct  595  QAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQFVMWKNDRFFEER  639

68) Sgly_2022 in NC_015172


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  374 bits (1405),  Expect = 1e-104, Method: Compositional matrix adjust.
 Identities = 261/651 (41%), Positives = 414/651 (64%), Gaps = 35/651 (5%)

Query  1    MGKSLVIAEKPSVGREIAKMLSCHKKDQGYFTGPKYLVTWALGHLVTLADPEKYDQRYKT  60
            M   LVIAEKPSV+R IA +++   K++GY+ G  YLV+W +GHLV++AD+ +YD+R+K 
Sbjct  1    MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK  60

Query  61   WKMDDLPMLPEQMELVVIKETSKQFSVIKNLMKMPDLDELIIATDAGREGELVARWIIKK  120
            W+ +DLP+LPE  + +V  +  +QF V+ +LM+ PD+  L+ ATDAGREGEL+ R + + 
Sbjct  61   WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM  120

Query  121  AGWRKPIKRLWISSQTERAIKEGFAALKPAKEYDHLYASAECRAQADWLIGLNVTRALTC  180
            AG +KP+ RLWISS  + AIK+GFA LKP+ +YD LY SA CRA+ADWLIG+N TR ++ 
Sbjct  121  AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV  180

Query  181  KFSAQLSAGRVQTPTLAMVVEREKQIKSFVPKEFWTIQAFTKGFSMTWHDKTNGQSRIFD  240
             +  +L+ GRVQTPTL M+V+R+ +I  F    +  ++  + G        +++ S  F 
Sbjct  181  LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG--------ADAVSSRFS  232

Query  241  QSKADQMIKKISGH-DAeiteikkeskkeLPPLAYDLTELQRDANRKYGFSAKTTSSVMQ  299
            ++   + +K   +  +A    + +E K E PP  YDLT LQR+ANR +G++AK T    Q
Sbjct  233  DAAEANTVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQ  292

Query  300  QLYEYHKIVTYPRTDSRYITEDIVSTLPERLNSI-AVGPYAQFAAKILKNKITTTKRFVD  358
             LY   K++TYPRTDS+Y+T+D+++++   ++++  + P+A+  +  L  ++    R+++
Sbjct  293  ALY-LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAK--GLNLSPQF---DRILN  346

Query  359  QSKVSDHHAIIPTEQPVH--LQKLSNEEYKIYDLIVKRFLAVLSKPFEYEQTTVKADIRG  416
              KVSDHHAIIPT + V   +  L++ E K+  LI  ++L  ++ P  YE  T      G
Sbjct  347  SKKVSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAG  406

Query  417  ELFEVKGKIVKQNGWKEV---YQGTGNWeeeqedeereqTLPDLHKGERIPILEVKTKAG  473
            + F  KGK V   GWKE+   ++++ +  + +ED E  + LP+L  G+ ++ +       
Sbjct  407  QEFTAKGKTVLSPGWKEIERRFRSSLK-TDADEDAEAVRELPELCEGQTFADVAASVTEH  465

Query  474  KTKPPARYTEATLLTAMEHPGKNIENEKLREAVKQTGGLGTPATRAEIIEKLFSSFYLER  533
             T PP  YTE TLL+AME++G     E + E   +  GLGTPATRA I+EKL    +++R
Sbjct  466  FTTPPKPYTEDTLLSAMERAG----AEDMPEDAERK-GLGTPATRAAILEKLVQMGFVQR  520

Query  534  NGKEIFPTSKGLQLIELVPVDLKSAELTAKWEQQLSEISKGKVKSTEFLNGIRSYARQLV  593
            +GK+++PT  G++L  ++P  L S++LTA WE++L+EI+KG+  + EF++GI + AR+LV
Sbjct  521  KGKQLIPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELV  580

Query  594  ST---VSENNQ-VFRHDNLTRNKCPECGKFLLQVKGKKGELLICQDRECGY  640
             T   +SE++Q +F+ + +    CP CG  + +  GKK     C +R C +
Sbjct  581  QTYSCISEEKQKLFQAERVPIGTCPRCGEAVYE--GKKN--YYCGNRACQF  627

69) GYMC52_1650 in NC_014915


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  373 bits (1401),  Expect = 3e-104, Method: Compositional matrix adjust.
 Identities = 260/649 (41%), Positives = 396/649 (62%), Gaps = 42/649 (6%)

Query  4    LVLAEKPSVARDIARVLGCKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYETWRLE  63
            LV+AEKPSVAR IA V+G  E H  Y+EG  Y+V+W +GHLV +  +  YD ++  WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWT  123
            DLPI+P      V  +  +QF  +  L +RPDV +++ ATDAGREGEL+ R + +M G  
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVSRALTTKYND  183
            KP+ RLWISS  D AI+DGF +LKPG+++D LYQSA+CRA ADWLIG+N +R ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  PLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEAKQ  243
             L+ GRVQTPTL M+++R+  I  F    Y  ++   G+  AV     + R+ D  EA+ 
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-----SSRFSDAAEANT  239

Query  244  LLARLDGQPARVVSVKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHK  303
            + A      A  VSV R +K+E +P  YDLT LQR+AN+ FG++AK+TL   Q LY   K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LKK  298

Query  304  LVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLakgkakaakRVFNDDKVTDHH  363
            L+TYPRTDS+YL  DM +++     ++ SG  ++++   +   +    R++N  KV+DHH
Sbjct  299  LLTYPRTDSQYLTDDMLPAVE----SLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHH  354

Query  364  AIVPTDE--RLNLSRLSTDERKLYDLIARRFLALFFPPYESETTTAVFDIGGEMFVAKET  421
            AI+PT E  +  ++ L+  E+KL  LI  ++L     P   E+ TA F  +G+ F AK  
Sbjct  355  AIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGK  414

Query  422  AVVNFG-------FKAVL---GKEETDAKPTLSHLAEGQTLPSVQLEREQSFTEPPARYS  471
            +V++ G       F++ L   + E+++A   L++L EGQT++ V     + FT PP  Y+
Sbjct  415  TVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYT  474

Query  472  EADLLAQMEKY------------GLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQL  519
            E  LL+ ME+             GLGTPATRA I+E+LV+   V+RK+ ++ PTK G +L
Sbjct  475  EDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINL  534

Query  520  IELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTQQLVAEIK----QSEQVY  575
              ++ E L SP+LTA WE  L  IA+G+++P++F+  I  Q+++LV        + ++++
Sbjct  535  AVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLF  594

Query  576  KAPNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPKLSNRR  624
            +A  +   TCP CG  + E K    +   C+N AC++  +++ ++ + R
Sbjct  595  QAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQFVMWKNDRFFEER  639

70) GYMC61_2520 in NC_013411


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  373 bits (1401),  Expect = 3e-104, Method: Compositional matrix adjust.
 Identities = 260/649 (41%), Positives = 396/649 (62%), Gaps = 42/649 (6%)

Query  4    LVLAEKPSVARDIARVLGCKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYETWRLE  63
            LV+AEKPSVAR IA V+G  E H  Y+EG  Y+V+W +GHLV +  +  YD ++  WR E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWT  123
            DLPI+P      V  +  +QF  +  L +RPDV +++ ATDAGREGEL+ R + +M G  
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVSRALTTKYND  183
            KP+ RLWISS  D AI+DGF +LKPG+++D LYQSA+CRA ADWLIG+N +R ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  PLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEAKQ  243
             L+ GRVQTPTL M+++R+  I  F    Y  ++   G+  AV     + R+ D  EA+ 
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-----SSRFSDAAEANT  239

Query  244  LLARLDGQPARVVSVKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHK  303
            + A      A  VSV R +K+E +P  YDLT LQR+AN+ FG++AK+TL   Q LY   K
Sbjct  240  VKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LKK  298

Query  304  LVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLakgkakaakRVFNDDKVTDHH  363
            L+TYPRTDS+YL  DM +++     ++ SG  ++++   +   +    R++N  KV+DHH
Sbjct  299  LLTYPRTDSQYLTDDMLPAVE----SLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHH  354

Query  364  AIVPTDE--RLNLSRLSTDERKLYDLIARRFLALFFPPYESETTTAVFDIGGEMFVAKET  421
            AI+PT E  +  ++ L+  E+KL  LI  ++L     P   E+ TA F  +G+ F AK  
Sbjct  355  AIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGK  414

Query  422  AVVNFG-------FKAVL---GKEETDAKPTLSHLAEGQTLPSVQLEREQSFTEPPARYS  471
            +V++ G       F++ L   + E+++A   L++L EGQT++ V     + FT PP  Y+
Sbjct  415  TVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYT  474

Query  472  EADLLAQMEKY------------GLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQL  519
            E  LL+ ME+             GLGTPATRA I+E+LV+   V+RK+ ++ PTK G +L
Sbjct  475  EDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINL  534

Query  520  IELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTQQLVAEIK----QSEQVY  575
              ++ E L SP+LTA WE  L  IA+G+++P++F+  I  Q+++LV        + ++++
Sbjct  535  AVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLF  594

Query  576  KAPNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPKLSNRR  624
            +A  +   TCP CG  + E K    +   C+N AC++  +++ ++ + R
Sbjct  595  QAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQFVMWKNDRFFEER  639

71) PPE_00753 in NC_014483


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  370 bits (1391),  Expect = 2e-103, Method: Compositional matrix adjust.
 Identities = 252/619 (41%), Positives = 384/619 (63%), Gaps = 36/619 (5%)

Query  4    LVLAEKPSMAREIARVMGSREKYKSYIEGPQYVVTWALGHLVGLAEPEDYDSKYATWNLE  63
            LV+AEKPS+AR IA V+G+ EK  +Y+EG  Y+V+W +GHLV++A++  YD ++  W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPILPKSSKLKVLRESNHQFKAVQQLMKRPDIGELIVATDAAREGELLARWIIQMANWK  123
            DLPILP + +  V  + ++QF  +  LM+RPD+  L+ ATDA+REGEL+ R + QMA  +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPFRRLWISSQTDKAIKAGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTCRYNA  183
            KPF RLWISS  D AIK GFA L PG ++D LY+SA CRA ADW+IG+N TR ++  Y+ 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLSAGRVQTPTLGMIMEREKEITEFRSQEYDTLTADFGDFQATWRAESGDSRMFDRTQAE  243
            +L+ GRVQTPTL M+++R+  IT+F+ + Y+ +    G+      A++  SR  D ++A+
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGG------ADAVSSRFSDAAEAN  238

Query  244  ALRRRLEGAKGTVASVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNLLQRLYEQH  303
            +++     A++   SV +  K E  P  YDLT LQR+AN+ +G++AKQT +  Q LY   
Sbjct  239  TVKAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-LK  297

Query  304  KLVTYPRTDSRYLTSDMVDTLKERLSSV-AVGPYASLARPLLRNNLPITKRIVDDSKVTD  362
            KL+TYPRTDS+YLT DM+ ++   +S++  + P+   A+ L  N  P   RI++  KV+D
Sbjct  298  KLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGL--NLSPQFDRILNSKKVSD  352

Query  363  HHAIIPTEQTLL--LNQLSPEERKLYDLIARRFISLFYPPARYDAVAVSVTVEQETFQVK  420
            HHAIIPT + +   +  L+  E+KL  LI  +++     P  Y+AV+ + T   + F  K
Sbjct  353  HHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAK  412

Query  421  GTTVKDSGWRAVYDANHYDMD-DEEAEDRENNGRGVILPELQKGDSVRLQRCLVRAGRTM  479
            G TV  +GW+ +    ++      +A++  +  R   LPEL  G++       V    T 
Sbjct  413  GKTVLSPGWKEI--ERRFRSSLKTDADEDAEAVRE--LPELCEGQTFADVAASVTEHFTT  468

Query  480  PPKRYTEAALLAQM------------EKHGLGTPATRADLIEKLVSSDTIERQGNVMHPT  527
            PPK YTE +LL+ M            E+ GLGTPATRA ++EKLV  + ++R+G+ + PT
Sbjct  469  PPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPT  528

Query  528  GKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPEPFLNSIRAMAKELVSTVKNSSA  587
              G +L  + +  L +P+LTA WE  L  IA+GQ++P+ F+++I + A+ELV T    S 
Sbjct  529  KDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISE  588

Query  588  E----YKPHNVTNSHCPDC  602
            E    ++++ V  + CP C
Sbjct  589  EKQKLFQAERVPIGTCPRC  607

72) KNP414_02988 in NC_015690


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  356 bits (1336),  Expect = 4e-99, Method: Compositional matrix adjust.
 Identities = 259/646 (41%), Positives = 391/646 (61%), Gaps = 43/646 (6%)

Query  31   LVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDPKYKTWNLE  90
            LV+AEKPSVA+ IA V+G  +KH  Y+EG  Y+V+W +GHLV++A++  YD ++K W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  91   DLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWR  150
            DLP+LP   +  V  +   QF  +  L QR D+  L+ ATDAGREGEL+ R + ++   +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  151  KPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNA  210
            KP+ RLWISS  D AI+DGFA+LKPG  YDPLY+SA+CRA ADWLIG+N TR ++   + 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  211  QLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAA  270
            +L+ GRVQTPTL  ++DR+A+I  F+   + +++   G+ +A+        +R+ D A A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-------SSRFSDAAEA  237

Query  271  DTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYE  330
            +T+      A++  VS  +   K+E  P  YDLT LQR+AN+ +G+TAKQT +  Q LY 
Sbjct  238  NTVKAACAKAQAVCVSVTR-EKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-  295

Query  331  QHKLVTYPRTDSRYLSSDMVSTLPDRLKALLG-TPYGASAKGL-LARPLPVTKRIVDDSK  388
              KL+TYPRTDS+YL+ DM++++   + +L    P+   AKGL L+  +    RI++  K
Sbjct  296  LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGLNLSPQF---DRILNSKK  349

Query  389  VSDHHAIIPTDE--RPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESF  446
            VSDHHAIIPT E  +  +  L+  E++L  LI  ++L     +  Y+  + T+  AG+ F
Sbjct  350  VSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEF  409

Query  447  HAKGRIVKDQGWKAVYDGssapseaddddapeeepsslqslpalqlGTELKDLRLSQQKG  506
             AKG+ V   GWK +         +     ++E++ +++ LP L  G  + D+  S    
Sbjct  410  TAKGKTVLSPGWKEI----ERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEH  465

Query  507  TTKPPGRYTEAGLLSVM------------EKQGLGTPATRADIIEKLLSTDTIERRMNTL  554
             T PP  YTE  LLS M            E++GLGTPATRA I+EKL+  + ++R+ + L
Sbjct  466  FTTPPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQL  525

Query  555  QPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKN  614
             PT  G++L  ++   L S++LTA WE  L  IAKGQ+DPD FM GI  Q+  +V+    
Sbjct  526  IPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSC  585

Query  615  SSAE----YKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNY  656
             S E    ++++ +  + CP CG ++ + K    +   C++R C++
Sbjct  586  ISEEKQKLFQAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQF  627

73) PM3016_3225 in NC_016935


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  355 bits (1332),  Expect = 8e-99, Method: Compositional matrix adjust.
 Identities = 259/646 (41%), Positives = 391/646 (61%), Gaps = 43/646 (6%)

Query  4    LVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDLKYKTWNLE  63
            LV+AEKPSVA+ IA V+G  +KH  Y+EG  Y+V+W +GHLV++A++  YD ++K W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWR  123
            DLP+LP   +  V  +   QF  +  L QR D+  L+ ATDAGREGEL+ R + ++   +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNA  183
            KP+ RLWISS  D AI+DGFA+LKPG  YDPLY+SA+CRA ADWLIG+N TR ++   + 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAA  243
            +L+ GRVQTPTL  ++DR+A+I  F+   + +++   G+ +A+        +R+ D A A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-------SSRFSDAAEA  237

Query  244  DTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYE  303
            +T+      A++  VS  +   K+E  P  YDLT LQR+AN+ +G+TAKQT +  Q LY 
Sbjct  238  NTVKAACAKAQAVCVSVTR-EKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-  295

Query  304  QHKLVTYPRTDSRYLSSDMVSTLPDRLKALLG-TPYGASAKGL-LARPLPVTKRIVDDSK  361
              KL+TYPRTDS+YL+ DM++++   + +L    P+   AKGL L+  +    RI++  K
Sbjct  296  LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGLNLSPQF---DRILNSKK  349

Query  362  VSDHHAIIPTDE--RPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESF  419
            VSDHHAIIPT E  +  +  L+  E++L  LI  ++L     +  Y+  + T+  AG+ F
Sbjct  350  VSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEF  409

Query  420  HAKGRIVKDQGWKAVYDGssapseaddddapeeepsslqslpalqlGTELKDLRLSQQKG  479
             AKG+ V   GWK +         +     ++E++ +++ LP L  G  + D+  S    
Sbjct  410  TAKGKTVLSPGWKEI----ERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEH  465

Query  480  TTKPPGRYTEAGLLSVM------------EKQGLGTPATRADIIEKLLSTDTIERRMNTL  527
             T PP  YTE  LLS M            E++GLGTPATRA I+EKL+  + ++R+ + L
Sbjct  466  FTTPPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQL  525

Query  528  QPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKN  587
             PT  G++L  ++   L S++LTA WE  L  IAKGQ+DPD FM GI  Q+  +V+    
Sbjct  526  IPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSC  585

Query  588  SSAE----YKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNY  629
             S E    ++++ +  + CP CG ++ + K    +   C++R C++
Sbjct  586  ISEEKQKLFQAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQF  627

74) B2K_16715 in NC_017672


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  355 bits (1332),  Expect = 8e-99, Method: Compositional matrix adjust.
 Identities = 259/646 (41%), Positives = 391/646 (61%), Gaps = 43/646 (6%)

Query  4    LVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDLKYKTWNLE  63
            LV+AEKPSVA+ IA V+G  +KH  Y+EG  Y+V+W +GHLV++A++  YD ++K W  E
Sbjct  5    LVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKKWRYE  64

Query  64   DLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWR  123
            DLP+LP   +  V  +   QF  +  L QR D+  L+ ATDAGREGEL+ R + ++   +
Sbjct  65   DLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQMAGCQ  124

Query  124  KPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNA  183
            KP+ RLWISS  D AI+DGFA+LKPG  YDPLY+SA+CRA ADWLIG+N TR ++   + 
Sbjct  125  KPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSVLYHK  184

Query  184  QLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAA  243
            +L+ GRVQTPTL  ++DR+A+I  F+   + +++   G+ +A+        +R+ D A A
Sbjct  185  NLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAV-------SSRFSDAAEA  237

Query  244  DTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYE  303
            +T+      A++  VS  +   K+E  P  YDLT LQR+AN+ +G+TAKQT +  Q LY 
Sbjct  238  NTVKAACAKAQAVCVSVTR-EKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALY-  295

Query  304  QHKLVTYPRTDSRYLSSDMVSTLPDRLKALLG-TPYGASAKGL-LARPLPVTKRIVDDSK  361
              KL+TYPRTDS+YL+ DM++++   + +L    P+   AKGL L+  +    RI++  K
Sbjct  296  LKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPF---AKGLNLSPQF---DRILNSKK  349

Query  362  VSDHHAIIPTDE--RPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESF  419
            VSDHHAIIPT E  +  +  L+  E++L  LI  ++L     +  Y+  + T+  AG+ F
Sbjct  350  VSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEF  409

Query  420  HAKGRIVKDQGWKAVYDGssapseaddddapeeepsslqslpalqlGTELKDLRLSQQKG  479
             AKG+ V   GWK +         +     ++E++ +++ LP L  G  + D+  S    
Sbjct  410  TAKGKTVLSPGWKEI----ERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEH  465

Query  480  TTKPPGRYTEAGLLSVM------------EKQGLGTPATRADIIEKLLSTDTIERRMNTL  527
             T PP  YTE  LLS M            E++GLGTPATRA I+EKL+  + ++R+ + L
Sbjct  466  FTTPPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQL  525

Query  528  QPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKN  587
             PT  G++L  ++   L S++LTA WE  L  IAKGQ+DPD FM GI  Q+  +V+    
Sbjct  526  IPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSC  585

Query  588  SSAE----YKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNY  629
             S E    ++++ +  + CP CG ++ + K    +   C++R C++
Sbjct  586  ISEEKQKLFQAERVPIGTCPRCGEAVYEGK----KNYYCGNRACQF  627

75) FPR_19060 in NC_021020


> NC_021994_R1|38|G38|529233432|YP_008394244.1|Enterococcus_faecium_Aus0085|+|34146..36227|-|EFAU085_00720|DNA 
topoisomerase 
III
Length=693

 Score =  337 bits (1264),  Expect = 1e-93, Method: Compositional matrix adjust.
 Identities = 222/530 (42%), Positives = 340/530 (65%), Gaps = 17/530 (3%)

Query  1    MVGINASRLFSCLYNQPLAVGRVMTPVLAMTVVREAAIAAFTPEKFYTVDLELTSGCTAS  60
            ++GINA+RLFS LY++ L+VGRV TP L M V R+A I+ F  EK+  V++  ++G  A 
Sbjct  169  LIGINATRLFSVLYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHIT-AGGADAV  227

Query  61   SRRIPEKSVAENLLKACRKEMVATIQRITRKEKSENPPPLYDLTTLQRDANRLLGYSAQQ  120
            S R+++ + A+ +  AC K     +  +TR  K+E+PP LYDLTTLQR+ANRL+GY+A+Q
Sbjct  228  SSRFSDAAEANTVKAACAKAQAVCVS-VTREKKTEQPPKLYDLTTLQREANRLFGYTAKQ  286

Query  121  TLDYVQSLYEKKLTTYPRTDSCYITdddeemleelteelegfldITSADVDEAVPRTRRT  180
            TLDY Q+LY KKL TYPRTDS Y+TDD    +E L   L  ++ ++ +   +  P+  R 
Sbjct  287  TLDYAQALYLKKLLTYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKG--LNLSPQFDRI  344

Query  181  VNREKVTDHHAILPTRSMLQADLDALPKGEQNVLKLIIARTLMAVSKPFRYLETLLTTEC  240
            +N  KV+DHHAI+PT   ++ ++++L+ +E+++L LI  + L AV+ P  Y     T  C
Sbjct  345  LNSKKVSDHHAIIPTAEFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTC  404

Query  241  AGEEFTAKGKEILEEGWKAVERK----VLADILNRKQELTALPNAAENE-YGILNAELKE  295
            AG+EFTAKGK +L  GWK +ER+    + +D  +  + +  LP+  E + ++ + A + E
Sbjct  405  AGQEFTAKGKTVLSPGWKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTE  464

Query  296  GQTSPPKHFTEDTLLHAMETASADSMPEGVERQGIGTPATRAATIEKLVQKGFLERKGTK  355
              T+PPK +TEDTLL AME A+A+ MPE+ ER+G+GTPATRAA +EKLVQ GF++RKG  
Sbjct  465  HFTTPPKPYTEDTLLSAMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKG--  522

Query  356  KTKVLLPTDKGKALITVMPEEIQSADMTADWEAKLLQIERSEMEPETFMTEIKEMISSLV  415
              K L+PT  G  L  V+PE + S+++TA+WE +L +I +++ +P+ FM  I      LV
Sbjct  523  --KQLIPTKDGINLAVVLPEALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELV  580

Query  416  TTTEAAKGANA--LMKNKI-IGVCPNCGANVVEREKGWFCESNPCRFVLWKDNAFFKRLG  472
             T       +   +  +++ IG CP CG  V E  K  +C + +C+FV+WK++ FF    
Sbjct  581  QTYSCISEEKQKLFQAERVPIGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERK  640

Query  473  KRLDGRMADKLLRDGHVRLKD-CKSAKGKTYNATVLLSTEPDGRSKFSLE  521
            K +  ++A  LL+ G V++K+      GKTY++TVLL+   +   ++ +E
Sbjct  641  KAFTPKIAAALLKTGKVKVKGLYSVKTGKTYDGTVLLADTGGKYVNYRIE  690