> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score = 1055 bits (3998),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 647/647 (100%), Positives = 647/647 (100%), Gaps = 0/647 (0%)

Query  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60
            MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120
            RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180
            QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240
            EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300
            CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360
            AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420
            FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480
            FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540
            TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600
            KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647
            QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score = 1055 bits (3998),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 647/647 (100%), Positives = 647/647 (100%), Gaps = 0/647 (0%)

Query  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60
            MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120
            RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180
            QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240
            EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300
            CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360
            AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420
            FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480
            FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540
            TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600
            KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647
            QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score = 1055 bits (3998),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 647/647 (100%), Positives = 647/647 (100%), Gaps = 0/647 (0%)

Query  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60
            MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120
            RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180
            QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240
            EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300
            CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360
            AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420
            FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480
            FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540
            TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600
            KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647
            QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score = 1055 bits (3998),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 647/647 (100%), Positives = 647/647 (100%), Gaps = 0/647 (0%)

Query  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60
            MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120
            RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180
            QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240
            EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300
            CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360
            AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420
            FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480
            FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540
            TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600
            KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647
            QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score = 1053 bits (3992),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 646/647 (99%), Positives = 646/647 (99%), Gaps = 0/647 (0%)

Query  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60
            MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120
            RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180
            QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240
            EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300
            CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360
            AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEVT  420
            FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTE T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480
            FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540
            TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600
            KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647
            QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  756 bits (2859),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 418/669 (63%), Positives = 544/669 (82%), Gaps = 6/669 (0%)

Query  1    MKLFLCEKPSQGRDIAVVLGATKRGQGYLTGPGVTVTWAVGHLLETASPEVYGEQYGAPW  60
            M+L LCEKPSQGRDIA  LGAT+RG+G+L GPGVTVTWA GHLLETA PEVYGEQYG PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RASVLPILPASWQMVVKKETADQFTVICRLLKQADEVVIATDADREGEVIARELLDYCQF  120
            R+ VLP+LP  W++VVK ++  QF+VI RLLKQ DEVVIATDADREGEVIARELLDYC+F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGKISRLWLSALDEVSIRAALANILPGEQTASLYLAGLGRARADWLIGMNFTRLYTVKAR  180
            QG++ RLW+SALD+ SIR+ALA++ P+ +T SLY AG+GR+RADWLIGMN+TRL+T+ +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ECGYSDILSIGRVQTPSLALVVFRDREIIAFTAKPYWQVVADLQFDGRIFRADWVPAATY  240
            E G +++LS+GRVQTP+LA+VV RDREI  F +KPY +V+A +  +G +F + WVPAA Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIHQNVAQTVVKLCQQTGTATVLEINTKREKHAAPLAFDLGSLQQLCSKKWSMG  300
            CDEEKRCI+  VA  VV+LC+QT TA++++ +  R K++APLAF L++LQQ CS+ W+M 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQQVLNIAQNLYETHKATTYPRTDCGYLPTAMQAEIPQVLDAVVKSDPAMRIVVDSLDRT  360
            AQ VL+IAQ+LYETHK TTYPRTDCGYLP +M+ EIPQVL AVV +DPA++ VV SLD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  LISRIWNDKKITAHHGIIPTKQPCDMNKMTDDERKVYQLIRQHYLLQFLPLHEMDITEAT  420
            ++SRIWNDKKITAHHGIIPTK+  D++K++D ER+VYQL+R HYL QFLP  E+D+TEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FDIGGQLFRTRGNVVIVPGWKVLFSAGKDESASIGKDDSLGESLPSMVKGNQCQVNEATL  480
            F+IGGQLFRTRGNV++ PGWK LF+   ++      D++   +LP+M  G+ CQV+ A  
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDE----DNTGETTLPAMQAGQVCQVQGAEQ  476

Query  481  RMLQTQPSAHFTEGTLIAAMKNAAAFVSDPQLKKVLKDNAGLGTEATRAGVLDTLFKRGY  540
            ++LQT+P+A + +GTLIAAM NAAAFV+D+ LKKVLK+NAG+GTEATRAG++DTL+KRG+
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  541  LTKKGKYIHATQIASELIAALPTALTNPGLTALWEQALDDIAQGQAELPDFMARQVQWTQ  600
            L +  K + +T ++ +L+  LP +LTNPGLTALWEQ LD++A G+  L DFMA+Q QW  
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  601  YLVEQVQAQKVVITPPPSLPCPVCGGVTRQRQGKNGVFWGCIKYPECSGVVSTVDGKRKT  660
             LV Q ++Q + + +PPS PCPVCGG T QR+GK+G+FWGC+KYPEC G+V+  +G++  
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN--NGNKGP  654

Query  661  RSARHKNIP  669
            R+ R+K  P
Sbjct  655  RGRRRKPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  728 bits (2755),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 398/670 (60%), Positives = 545/670 (82%), Gaps = 8/670 (1%)

Query  1    MRLFICEKPSQARDIAAVIGATKRGQGFLSAPGITITWARGHLLETASPEVYGTQFEKPW  60
            MRL +CEKPSQ+RDIA  +GAT+RG+GFL++PG+T+TWARGHLLETA PEVYG Q+ KPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RIDVLPVLPPVWQMVVKPESLDQFTVISRLLKQVDEVVISTDADREGEVIGWSLLEYCGW  120
            R DVLP+LP  W++VVK+++  QF+VI+RLLKQVDEVVI+TDADREGEVI++ LL+YC  
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGPVFRLWLSALDESSIRTALAAIKPGAETKPLYYAGLGRSRADWLIGMNLTRLYTVKAR  180
            +G VFRLW+SALD++SIR+ALA + P++ T +LYYAG+GRSRADWLIGMNLTRL+T+ +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  DKGYDGLLSVGRVQTPVLAMVVNREREIAAFVPKPYWQVWVALQSNGVRFSAQWVPAKMY  240
            + G + +LSVGRVQTP LA+VV+R+REI  FV+KPY +V  ++  NGV F+++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  VDEEKRCIHQGIAQQVAQLCKQTGKATVIEQETKREKEAAPLAFTMGTLQQACGRLWDMS  300
             DEEKRCI+ G+A QV QLC+QT  A++I+ +  R K++APLAF+++TLQQAC+R W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQKVLDIAQSLYETHKATSYPRTDCGFLPESMREEIPDVLSALVKIDPSLQELIPQLDTR  360
            +Q VLDIAQ LYETHK T+YPRTDCG+LP SMREEIP+VLSA+V  DP+LQ +++ LDT+
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWDDKNITAHHGIIPTRHVSDMSKMSEQEKQVYLLIRRHYLAQFLPLHEVDATRLS  420
            FVSRIW+DK+ITAHHGIIPT+H +D+SK+S+ E++VY L+R HYLAQFLP  E+D T  +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LNIGGQLFQTTGRVVVVPGWKRLFSQQDDGEHKESAADEKDQSLPMLVKGDNCAVTGAEV  480
            +NIGGQLF+T G V+V PGWK LF++  ++++ +++    + +LP +  G+ C V GAE 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG----ETTLPAMQAGQVCQVQGAEQ  476

Query  481  KALKTKPPQYFTFQSLIAAMMNAAAYVTDLTLKKVLKENAGLGTEATRGGIVETLLARNF  540
            K L+TKPP  +   +LIAAM NAAA+VTD +LKKVLKENAG+GTEATR+GI++TLL R F
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  541  IIIKGRYLRATDIAMDLIDALPHALKEPGMTALWEQALDEVAKGKMTLDNFMSRQTQWIC  600
            ++   + L++T ++ +L+D LP +L +PG+TALWEQ LDEVA G+++LD+FM++Q+QW+ 
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  601  QLVSLGAQQDVVVRVPPTPACPLCGSKTRLRKGVKGSFYGCEKYPDCKGMINIPGQGKNT  660
            QLV+ G  Q + ++ PP+P+CP+CG+KT  R+G  G F GC KYP+CKG++N   +G   
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKG---  653

Query  661  APKTRKKKQN  670
             P+ R++K +
Sbjct  654  -PRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  727 bits (2751),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 422/664 (64%), Positives = 538/664 (82%), Gaps = 2/664 (0%)

Query  1    MKLFLCEKPSQGRDIAAVLGATKKMPGHQTGNGVCVTWGFGHLLEQASPDAYGEQFGVPW  60
            M+L LCEKPSQGRDIA  LGAT++  G   G GV VTW+ GHLLE A P+ YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPVLPTMWQMRVKPDAAAQFSVIQKLLKQADTVVIATDADREGEVIAREILDYCHY  120
            RTDVLP+LP  W++ VK+DA AQF+VI++LLKQ D VVIATDADREGEVIARE+LDYC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGKVERLWLSALDEASVRAALATIKPGSTTLPYYLAGLGRARADWQIGMNMTRLYSVKAR  180
            QG+V RLW+SALD+AS+R+ALA + P+S T + Y AG+GR+RADW IGMN+TRL+++ +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ENGYGSVLSVGRVQTPTLNLIVVRDRDIVQFVPKPYWNVVAQLAAGGIAFQAQWVPAEAY  240
            E G G+VLSVGRVQTPTL ++V RDR+I +FV+KPY +V+A +A  G+ F ++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCINPTAAQQVVQLCQKTGQATVAEVETKRETESAPLAFDLGTLQQACSRRFGYG  300
            CDEEKRCI++  A QVVQLC++T  A++ + +  R  +SAPLAF L+TLQQACSR+ G  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQQVLDIAQALYETYKATTYPRTDCGYLPTSMRGEIGQVMSSIQQSDPALSAIISRLDMK  360
            AQ VLDIAQ LYET K TTYPRTDCGYLP SMR EI QV+S++  +DPAL ++++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  HVSRIWNDKKITAHHGIIPTKQPCDLAKMSEQERNVYQLIRLHYLAQFLPNHEVDATRVS  420
             VSRIWNDKKITAHHGIIPTK+  DL+K+S+ ERNVYQL+RLHYLAQFLP+ E+D T  +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LHCGGQLFKTSGKAVVVAGWKSLFgkdadedagdagdkaRLPAMAKGSLCQVTGAEAKPQ  480
            ++ GGQLF+T G+ +V +GWKSLFGK +++D +++G+ + LPAM  G +CQV GAE K  
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT-LPAMQAGQVCQVQGAEQKVL  479

Query  481  QTKPPEHYTEGTLIAAMKNAAQFVTDPRLKKILKENAGLGTEATRAGVIETLLKRGFVVK  540
            QTKPP  Y +GTLIAAM NAA FVTD+ LKK+LKENAG+GTEATRAG+I+TLLKRGF+V+
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  541  KGKHLLATPIAADLMAVLPAQLKDPGMTALWEQSLDDIAEGRMSLDDFMAKQSAWTMQLV  600
              K L +TP++ +L+ VLP+ L +PG+TALWEQ LD++A GR+SLDDFMAKQS W  QLV
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  601  AKGQHQTVKITLPPSPPCPICGGVTRQRTGKSGSFWGCVNYPDCNGIVNVGAKKP-GRRR  659
            A+G+ Q + +  PPSPPCP+CGG T QR GKSG FWGC++YP+C+GIVN G K P GRRR
Sbjct  600  AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRR  659

Query  660  KSPA  663
            K+++
Sbjct  660  KPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  727 bits (2751),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 422/664 (64%), Positives = 538/664 (82%), Gaps = 2/664 (0%)

Query  1    MKLFLCEKPSQGRDIAAVLGATKKMPGHQTGNGVCVTWGFGHLLEQASPDAYGEQFGVPW  60
            M+L LCEKPSQGRDIA  LGAT++  G   G GV VTW+ GHLLE A P+ YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RTDVLPVLPTMWQMRVKPDAAAQFSVIQKLLKQADTVVIATDADREGEVIAREILDYCHY  120
            RTDVLP+LP  W++ VK+DA AQF+VI++LLKQ D VVIATDADREGEVIARE+LDYC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  QGKVERLWLSALDEASVRAALATIKPGSTTLPYYLAGLGRARADWQIGMNMTRLYSVKAR  180
            QG+V RLW+SALD+AS+R+ALA + P+S T + Y AG+GR+RADW IGMN+TRL+++ +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ENGYGSVLSVGRVQTPTLNLIVVRDRDIVQFVPKPYWNVVAQLAAGGIAFQAQWVPAEAY  240
            E G G+VLSVGRVQTPTL ++V RDR+I +FV+KPY +V+A +A  G+ F ++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCINPTAAQQVVQLCQKTGQATVAEVETKRETESAPLAFDLGTLQQACSRRFGYG  300
            CDEEKRCI++  A QVVQLC++T  A++ + +  R  +SAPLAF L+TLQQACSR+ G  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQQVLDIAQALYETYKATTYPRTDCGYLPTSMRGEIGQVMSSIQQSDPALSAIISRLDMK  360
            AQ VLDIAQ LYET K TTYPRTDCGYLP SMR EI QV+S++  +DPAL ++++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  HVSRIWNDKKITAHHGIIPTKQPCDLAKMSEQERNVYQLIRLHYLAQFLPNHEVDATRVS  420
             VSRIWNDKKITAHHGIIPTK+  DL+K+S+ ERNVYQL+RLHYLAQFLP+ E+D T  +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LHCGGQLFKTSGKAVVVAGWKSLFgkdadedagdagdkaRLPAMAKGSLCQVTGAEAKPQ  480
            ++ GGQLF+T G+ +V +GWKSLFGK +++D +++G+ + LPAM  G +CQV GAE K  
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT-LPAMQAGQVCQVQGAEQKVL  479

Query  481  QTKPPEHYTEGTLIAAMKNAAQFVTDPRLKKILKENAGLGTEATRAGVIETLLKRGFVVK  540
            QTKPP  Y +GTLIAAM NAA FVTD+ LKK+LKENAG+GTEATRAG+I+TLLKRGF+V+
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  541  KGKHLLATPIAADLMAVLPAQLKDPGMTALWEQSLDDIAEGRMSLDDFMAKQSAWTMQLV  600
              K L +TP++ +L+ VLP+ L +PG+TALWEQ LD++A GR+SLDDFMAKQS W  QLV
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  601  AKGQHQTVKITLPPSPPCPICGGVTRQRTGKSGSFWGCVNYPDCNGIVNVGAKKP-GRRR  659
            A+G+ Q + +  PPSPPCP+CGG T QR GKSG FWGC++YP+C+GIVN G K P GRRR
Sbjct  600  AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRR  659

Query  660  KSPA  663
            K+++
Sbjct  660  KPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  723 bits (2734),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 401/652 (62%), Positives = 518/652 (80%), Gaps = 3/652 (0%)

Query  2    MRLFLCEKPSQGRDIARFIGATQRGKGFLSGTGTVVTWAFGHLLEVASPEEYGAQFGKPW  61
            MRL LCEKPSQGRDIA+F+GATQRG GFL+G G  VTWA GHLLE A PE YG Q+GKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  62   RMDVLPILPTEWKMVVKQSSADQFAVISRLLKQADEVVIATDADREGEVLARELLDYCHF  121
            R DVLP+LP +WK+VVK  +  QFAVI+RLLKQ DEVVIATDADREGEV+ARELLDYC F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  122  TGNVKRLWLSALDDASIRKGLDNLLPGEKTVRLYYAGMGRSKADWLIGMNLTRIYTLKAS  181
             G V RLW+SALDDASIR +L +L P+ +T  LYYAG+GRS+ADWLIGMNLTR++TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  182  EQGIDELLSIGRVQTPTLALVVQRDSDIENFSPKPYWQVFADIEKAGMTFRAQWVPAAGY  241
            E GI+++LS+GRVQTPTLA+VV+RD +I+NF +KPY +V+A +   G+ F ++WVPAA Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  242  CDDEKRCIQHNAALAVEQLCKQTATTSVVDVLLKREKTPAPLCFSLSVLQKACSDKWGMI  301
            CD+EKRCIQ   A  V QLC+QT+T+++++  + R K +APL FSLS LQ+ACS  WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  302  AQKVLEIAQSLYEVHKATTYPRTDCGYLPESMKGEVSDVLSAILQSDPAATSLIKDADRS  361
            AQ VL+IAQ LYE HK TTYPRTDCGYLP SM+ E+++VLSA++ +DPA  +++   D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  362  FVSRIWNDKKISAHHAIIPTKQPFDISKLSDDELNVYQLIRLHYFAQFFPLHESDVTDVT  421
            FVSRIWNDKKI+AHH+IIPTK+  D+SKLSD E NVYQL+RLHY+AQF+P  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  422  FNLGGQLFKTRGRVSVVIGWKKLFFNDKEPDIQSDENGSQGSLPVLHNGDICNVLDCEVK  481
            FN+GGQLF+TRG V V  GWK LF +  E D   ++N ++ +LP ++ G++C+V + E K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDD---EDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  482  AQQTKPPSRFTDGTLIDAMKNSASFISDPTLKKILRDNAGLGTEATRANILDVLFKRNYL  541
              QTKPP+ + DGTLI AM N+A+F++D++LKK+L++NAG+GTEATRA I+D L+KR +L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  542  KRREKFIYSTQLARELISQLPEALTNPGMTALWEQALDDVAEGRMSLDAFLQKQKEWTLR  601
             R  K + ST L+R+L+  LP +LTNPG+TALWEQ LD+VA GR+SLD F+ KQ +W  +
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  602  LVDRGRQQAIKLTAPVSPLCPQCGGIMRKRNSDNGVFWGCVKYPLCKGIISE  653
            LV +GR Q++ + AP SP CP CGG   +RN+ +G+FWGC+KYP CKGI+++
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNN  649

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  723 bits (2734),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 398/669 (60%), Positives = 542/669 (82%), Gaps = 7/669 (1%)

Query  1    MRLFICEKPSQARDIAAVLGATKRGQGFLSAPGITITWARGHLLETASPEVYGTQFEKPW  60
            MRL +CEKPSQ+RDIA  LGAT+RG+GFL++PG+T+TWARGHLLETA PEVYG Q+ KPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RIDVLPVLPPVWQMVVKSESSDQFTVISRLLKQVDEVVISTDADREGEVIGWSLLEYCGW  120
            R DVLP+LP  W++VVK+++  QF+VI+RLLKQVDEVVI+TDADREGEVI++ LL+YC  
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGPVFRLWLSALDESSIRAALAAIKPGSETKPLYYAGLGRSRADWLIGMNLTRLYTVKAR  180
            +G VFRLW+SALD++SIR+ALA + P+S T +LYYAG+GRSRADWLIGMNLTRL+T+ +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  DKGYDGLLSVGRVQTPVLAMVVNREREIATFVPKPYWQVWVALQSNGVRFSAQWVPAKMY  240
            + G + +LSVGRVQTP LA+VV+R+REI  FV+KPY +V  ++  NGV F+++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  VDEEKRCIHQDIAQQVAQLCKQTGKATVIEQETKREKEAAPLAFTMGTLQQACGRLWDMS  300
             DEEKRCI+ ++A QV QLC+QT  A++I+ +  R K++APLAF+++TLQQAC+R W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQKVLDIAQSLYETHKATSYPRTDCGFLPESMREEIPDVLSALVKIDPSLQALISQLDTR  360
            +Q VLDIAQ LYETHK T+YPRTDCG+LP SMREEIP+VLSA+V  DP+LQ++++ LDT+
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWDDKKMTAHHGIIPTRHVCDMSKMSDQEKQVYVLIRRHYLAQFFPLHEVDFTRLS  420
            FVSRIW+DKK+TAHHGIIPT+H  D+SK+SD E++VY L+R HYLAQF+P  E+D T  +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LNIGGQLFQTTGRVVVVPGWKRLFSQDDGEHKEAAADEKDQSLPMLVKGDNCGVAGSEVK  480
            +NIGGQLF+T G V+V PGWK LF++   ++ + +++    +LP +  G+ C V G+E K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET---TLPAMQAGQVCQVQGAEQK  477

Query  481  ALKTKPPQYFTFQSLIAAMMNAAAYVTDLTLKKVLKENAGLGTEATRGGIVETLLARNFI  540
             L+TKPP  +   +LIAAM NAAA+VTD +LKKVLKENAG+GTEATR+GI++TLL R F+
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  SIKGRYLRATDIAMDLIDALPHALKEPGMTALWEQALDEVAKGRMTLDSFMSRQTQWICQ  600
                + L++T ++ +L+D LP +L +PG+TALWEQ LDEVA GR++LD FM++Q+QW+ Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVSLGTQQDVVVRVPPTPACPLCGSKTRLRKGAKGAFYGCEKYPDCKGMINVPGQSKNAA  660
            LV+ G  Q + ++ PP+P+CP+CG+KT  R+G  G F GC KYP+CKG++N    + N +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN----NGNKG  653

Query  661  SKTRKKKQN  669
            ++ R++K +
Sbjct  654  PRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  718 bits (2716),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 426/653 (66%), Positives = 524/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPTQWKMTVKKETADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ VK ++  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRATLQKGGIAFPASWVPAANY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V AT+   G+ FP+ WVPAA+Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQLCQQTGHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQLC+QT  A +++   ERKK+SAPLAF L+TLQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQALSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTQSGSVARLDRT  360
            A+  L IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+    VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQFLP  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEVVAGWKVLFQHDVSEAKEESTDTDDVRLPALVKGETVAVAGAELK  480
            FNIGGQLFRTRG+V V +GWK LF      + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK---MSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI++TL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKAQAVKFtappsppcptcsGTMRRRAGKKGSGAFWGCSNYPTCQGIIN  653
            LV +G++Q++   APPSPPCP C+G   +R GK  SG FWGC +YP C+GI+N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGK--SGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  715 bits (2706),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 405/670 (61%), Positives = 531/670 (80%), Gaps = 6/670 (0%)

Query  1    MRLFLCEKPSQGRDIAAVLGATKRGTGFLQGPGVTVTWAVGHLLETASPEAYGTQFARPW  60
            MRL LCEKPSQGRDIA  LGAT+RG GFL+GPGVTVTWA GHLLETA PE YG Q+++PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   NIHALPVLPAQWQMVVKKETEDQFKAIAKLLKQVDEVVIATDADREGEVIARELLDFCQW  120
              + LP+LP QW++VVK ++  QF  I +LLKQVDEVVIATDADREGEVIARELLD+C+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGPVNRLWLSALDEPSIRNGLNNIKPGNETLALYYAGLGRARADWLTGMNLTRLYTLKAR  180
            +G V RLW+SALD++SIR++L ++ P++ T +LYYAG+GR+RADWL GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EKGFDGVLSVGRVQTPTLALVVNRDREIAIFVPKPYWQVNAALQACGMAFVARWVPAKMY  240
            E G++ VLSVGRVQTPTLA+VV+RDREI  FV+KPY +V A++   G+ F ++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  TDEEKRCVHQGIAQQVAQLCRQSGQAQVIEQEKKRETEAAPLAFSLGALQQACGKLWDMS  300
             DEEKRC++ G+A QV QLCRQ+  A +I+ +  R  ++APLAFSL++LQQAC++ W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQQVLDTAQSLYETHKATTYPRTDCGFLPESMREEIPLVLAALAKTDPSLTTTIATLDPR  360
            +Q VLD AQ LYETHK TTYPRTDCG+LP SMREEIP VL+A+  TDP+L   +A+LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKHASDMGNMNDVEKRVYELIRRHYLAQFLPLYERDVTRLD  420
            FVSRIWNDKKITAHHGIIPTKH++D+++++D E+ VY+L+R HYLAQFLP  E DVT   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LSIGGQLFRTTGQVVVVPGWKVLFSSATDRKGNAQGDEDNALPSLNKGDVCTVTVAEVKD  480
            ++IGGQLFRT G+V+V PGWK LF+  ++   +  G  + +LP+++ G+VC V  AE K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG--ETTLPAMQAGQVCQVQGAEQKV  478

Query  481  LKTKAPLYFTFDTLIAAMMNAASYVTDLQLKKVLKENAGLGTEATRASIIDTLLKRGYIV  540
            L+TK+P  +  +TLIAAM NAA++VTD  LKKVLKENAG+GTEATRA+IIDTLLKRG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  541  MNRRYLRATEVAMDLMDALPAPLKEPGMTALWEQALDEVAAGRMRLEDFMARQTGWTRQL  600
             +++ L++T ++ +L+D LP+ L +PG+TALWEQ LDEVAAGR+ L+DFMA+Q+ W  QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  601  VAQGLAQNMVIRLPPTPVCPLCGSKTRLRRGEKKAFYRCEKYPSCKGVVNVPDQVKRKSA  660
            VAQG +Q + ++ PP+P CP+CG+KT  R G    F  C KYP CKG+VN  +    K++
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGN----KGP  654

Query  661  KSTSRKPKQN  670
            ++  RKP   
Sbjct  655  RGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  714 bits (2699),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 394/653 (61%), Positives = 524/653 (81%), Gaps = 1/653 (0%)

Query  1    MRLFICEKPSQGRDLANVLGATRRGDGFLTGPGVTVTWAVGHLLETAPPEAYGQQYGKPW  60
            MRL +CEKPSQGRD+A+ LGAT+RG+GFL GPGVTVTWA GHLLETA PE YG+QYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   SLSALPILPSPWQVVVKKETKSQFKVIERLLRQVDDVVISTDADREGEVIARELLEYCRW  120
                LP+LP  W++VVK ++K+QF VI+RLL+QVD+VVI+TDADREGEVIARELL+YC+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  DGPVQRLWLSALDEMSIRAALQDLRPGAETLGMYHAGLGRARADWLIGMNLSRLYTLLAV  180
            +G V RLW+SALD+ SIR+AL DL+P++ T ++Y AG+GR+RADWLIGMNL+RL+TLL+ 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  QSGFDGVISVGRVQTPTLALVVRRDREIATFVPKPFWQVKALLSAGGRTFPAQWVPAKVY  240
            ++G++ V+SVGRVQTPTLA+VV+RDREI  FV+KP+ +V A ++  G  FP++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  TDEEKRCVHQNIAQQVAHLCRQAGAATVTECETKREKAAAPLAFSLGTLQQACGLLWDMS  300
             DEEKRC++  +A QV +LCRQ+ +A++ +C+  R K +APLAFSL+TLQQAC+  W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQQVLDTAQSLYEKHKATTYPRTDCGYLPESMREEIPSVLSAIGLSDPECSSLLSGLNTS  360
            +Q VLD AQ LYE HK TTYPRTDCGYLP SMREEIP VLSA+  +DP   +++++L+T 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTRNAFKFSALSEAERRVYTLIRRNYLAQFLPLHESDITRLQ  420
            FVSRIWNDKKITAHHGIIPT+++  +S LS+AER VY L+R +YLAQFLP  E D+T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FDIGGQLFRTTGRTEIVMGWKVLFSKEEEDSAGDDDLSIELPPLRQGDRCGVNGAEVVQQ  480
            F+IGGQLFRT G   +  GWK LF+K  ED  ++ +    LP+++ G+ C V+GAE    
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG-ETTLPAMQAGQVCQVQGAEQKVL  479

Query  481  MTRPPAHYTFATLIGAMMNASAFVTDIALRKVLKDNAGLGTEATRAGIVEQLLNRRFIVR  540
             T+PPA Y  +TLI+AM NA+AFVTD AL+KVLK+NAG+GTEATRAGI++ LL+R F+VR
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  541  KGKQLRATDLGADVIDALPSQLTDPGMTALWEQALDEVAEGRLTLNDFLQRQVGWTRNLV  600
              K L++T LG +++D LP+ LT+PG+TALWEQ LDEVA GR++L+DF+ +Q  W  +LV
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  601  SMGGQQRVSIRIPPTPSCPLCGGKTRLKKGQKGEFWGCTRYPDCKGIINNDTQ  653
            + G  Q ++++ PP+P+CP+CGGKT  ++G+ G FWGC +YP+CKGI+NN+ +
Sbjct  600  AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNK  652

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  714 bits (2699),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 382/654 (59%), Positives = 527/654 (81%), Gaps = 2/654 (0%)

Query  1    MQLYLCEKPSQAKDIARVLGVSQRGQGCINGGNITVTWAVGHLLETATPEIYGEQFGRPW  60
            M+L LCEKPSQ++DIA+ LG +QRG+G +NG  +TVTWA GHLLETA PE+YGEQ+G+PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RAEVLPIIPDRWQMTVKKDTADQFAVIKKLLKQASEVVIATDADREGEVIARELMEYCNY  120
            R++VLP++P++W++ VK D+  QFAVI++LLKQ  EVVIATDADREGEVIAREL++YC++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGAVRRLWLSALDEASIKKALGEMLPGDKTEMLYQAGVGRSRADWLIGMNLTRLYTLKAG  180
            +G V RLW+SALD+ASI+ AL+++ P+ +TE LY AGVGRSRADWLIGMNLTRL+TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGVSEVFSVGRVQTPTLAIVVNRDLEIAGFTPKPWWKVRAQLQKDDVSFEAEWVAAAQY  240
            EAG+++V+SVGRVQTPTLAIVV+RD EI  F +KP   V A +  ++V F + WV+AAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDDEKRCVNHPIAQAVQQLCQKAGSGSVISVEKKRDKTPAPLCFTLGTLMEVCNKKWGFG  300
            CD+EKRC++  +A  V QLC+++ ++++I+ +  R K +APL F+L+TL + C++ WG  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANEVLSIAQSLYETHKATTYPRTDCGYLPVSMREEVRDVLQAIQHSDPSITPELARLDTA  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP+SMREE+ +VL A+  +DP++ P +A LDT 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FTSRVWNDKKITAHHAIIPTRQPFEIAKLNAKELKVYSLIRLHYLAQFMPLQESDVTDAT  420
            F SR+WNDKKITAHH+IIPT++  +++KL+  E +VY L+RLHYLAQF+P  E DVT+AT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGNQLFRTRGRVMIHAGWKSLFSGQLSEEGEEDKESAAQLPALEQGSVCSVTGADVKD  480
            FNIG QLFRTRG V++ +GWKSLF G++SE+ +ED+ + + LPA++ G VC V GA+ K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLF-GKMSED-DEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  481  NMTKAPPHHTEGTLIAAMKNAASLVTDPQLKKVLRDNAGLGTEATRSGVLETLFKRGFLE  540
              TK+P+   +GTLIAAM NAA++VTD+ LKKVL++NAG+GTEATR+G+++TL+KRGFL 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  541  KKGKFIQATQMARELIAALPETLTSPGMTALWEQALDDIAQGKSGLSDFMQKQTQWTRHL  600
            +  K +++T ++R+L+  LP TLT+PG+TALWEQ LD++A G+ +L DFM KQ+QW  +L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  601  IEKGRVAAFKITVPVGPSCPKCGGPTQQRKNKEDKFWGCMKFPDCKGIVGETNR  654
            + +GR  ++ +  P +P+CP CGG T QR+ K + FWGC+K+P+CKGIV + N+
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNK  652

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  709 bits (2680),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 420/653 (65%), Positives = 524/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ +K D+  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V +T+   G+ FP++WVPAA+Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQ C+QT+ A +++   ERKK+SAPLAF L+TLQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRA  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+L+  VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQFLP  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELK  480
            FNIGGQLFRTRG+V   +GWK LF      + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK---MSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI++TL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKTQAVKFtappsppcptcsGSMrrragkkgggaFWGCSNYPTCQGVIN  653
            LV +G++Q++   APPSPPCP C+G       +  +G FWGC +YP C+G++N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGK--TLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  709 bits (2680),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 420/653 (65%), Positives = 524/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ +K D+  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V +T+   G+ FP++WVPAA+Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQ C+QT+ A +++   ERKK+SAPLAF L+TLQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRA  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+L+  VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQFLP  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELK  480
            FNIGGQLFRTRG+V   +GWK LF      + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK---MSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI++TL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKTQAVKFtappsppcptcsGSMrrragkkgggaFWGCSNYPTCQGVIN  653
            LV +G++Q++   APPSPPCP C+G       +  +G FWGC +YP C+G++N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGK--TLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  709 bits (2680),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 420/653 (65%), Positives = 524/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ +K D+  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V +T+   G+ FP++WVPAA+Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQ C+QT+ A +++   ERKK+SAPLAF L+TLQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRA  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+L+  VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQFLP  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELK  480
            FNIGGQLFRTRG+V   +GWK LF      + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK---MSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI++TL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKTQAVKFtappsppcptcsGSMrrragkkgggaFWGCSNYPTCQGVIN  653
            LV +G++Q++   APPSPPCP C+G       +  +G FWGC +YP C+G++N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGK--TLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  708 bits (2679),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 419/653 (65%), Positives = 523/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLVGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPAQWKMAVKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ VK D+  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRTMLQKDGIAFPANWVPAVNY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V + +  +G+ FP++WVPA +Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQLCQQTANAVVLDVGTERKKESAPLAFDLGILQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQLC+QT+ A +++   ERKK+SAPLAF L+ LQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTQSESVARLDRT  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+    VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQFLP  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEAVAGWKALFQHDASEAKEEPADTDDVRLPALVKGEAVSVAGAELK  480
            FNIGGQLFRTRG+V   +GWK+LF   +  + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLF---GKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI++TL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKFLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKAQAVKFtappsppcptcsGTMrrragkkgggaFWGCSNYPTCQGIIN  653
            LV +G++Q++   APPSPPCP C+G       +  +G FWGC +YP C+GI+N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGK--TLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  707 bits (2673),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 421/653 (65%), Positives = 524/653 (81%), Gaps = 5/653 (0%)

Query  1    MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPW  60
            M+L LCEKPSQG+DI+ +LGATQR +G+L G+GV VTWA GHLLE A+PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RESVLPIVPTQWKMAVKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHF  120
            R  VLP++P QWK+ VK D+  QFAVI  LLKQVD VVIATDADREGEVIARELL+ C F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAR  180
             G V RLW+SALD+ASIR ALA+  P+ +T +LY AG++RSRADW+ GMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGYGEVLSIGRVQTPTLALVVNRDRDITNFISKPYWQVRATLQKGGITFPANWVPAANY  240
            E G G+VLS+GRVQTPTLA+VV+RDR+I NF+SKPY +V AT+   G+ FP++WVPAA+Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMS  300
            CDEEKRCIQ  VA  VVQ C+QT+ A +++   ERKK+SAPLAF L+TLQQACSR WGM+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRA  360
            A+ VL IAQ LYETHK TTYPRTDCGYLP SMREE+++VLSAV  TDP+L+  VA LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQYLSLHEVDVTEAT  420
            FVSRIWNDKKITAHHGIIPTK+  DLSKLS  E +VYQL+R HYLAQ+L+  E+DVTEAT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELK  480
            FNIGGQLFRTRG+V   +GWK LF      + ++  +T++  LPA+  G+   V GAE K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK---MSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  481  TLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILDTLFKRGYL  540
             LQTKPP+ + DGTLIAAM NAAAFV+D+ LKKVLKENAG+GTEATRAGI+DTL+KRG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  541  EKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGH  600
             +  K L STP++ +L+D LP +LTNPG+TALWEQ LDE+A G+++LD FM++Q+QW ++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  601  LVEKGKTQAVKFtappsppcptcsGSMrrragkkgggaFWGCSNYPTCQGVIN  653
            LV +G++Q++   APPSPPCP C+G       +  +G FWGC +YP C+G++N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGK--TLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  700 bits (2647),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 394/650 (61%), Positives = 517/650 (80%), Gaps = 2/650 (0%)

Query  1    MRLFICEKPSQGRDLAAVLGATQRGDGFLAGSGITVTWAVGHLLETAPPEAYGQQYGKPW  60
            MRL +CEKPSQGRD+A  LGATQRG+GFL G+G+TVTWA GHLLETA PE YG+QYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   TLAALPIIPSPWQVVVKKETQHQFKIIERLLRQVDEVIIATDADREGEVIARELLDYCRW  120
                LP++P  W++VVK +++ QF +I+RLL+QVDEV+IATDADREGEVIARELLDYC+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  EGPVQRLWLSSLDELSIRAALQNLRPGGETLGMYHAGLGRARADWLTGMNLSRLYTLRAA  180
            +G V RLW+S+LD+ SIR+AL +L+P++ T ++Y AG+GR+RADWL GMNL+RL+TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGFDGVVSVGRVQSPTLALVVRRDREIAAFVPKPYWQVKAQLSAGGITFPAQWVPAKVY  240
            EAG++ V+SVGRVQ+PTLA+VV+RDREI  FV+KPY +V A ++  G+ FP++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  TDEEKRCIHQNIAQQVVQICRQSGEATVTECETKREKASPPLAFSLGTLQQAASRLWDMS  300
             DEEKRCI+  +A QVVQ+CRQ+  A++ +C+  R K S+PLAFSL+TLQQA SR W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQQVLDTAQSLYEKHKATSYPRTDCGYLPESMREEIPALLDAIGRTDPECLPLLSQLDAS  360
            +Q VLD AQ LYE HK T+YPRTDCGYLP SMREEIP +L A+  TDP   P+++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  LVSRIWNDKKITAHHGIIPTRNAFQLSALSETERQVYMLIRRNYLAQFLPLHESDITRLA  420
            +VSRIWNDKKITAHHGIIPT+++ +LS LS++ER+VY L+R +YLAQFLP  E D+T  +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FDIGGQLFRTTGRTEVVKGWKVLFGKaeeegsaaddeavvaLPPLKKDDRCGVTGAEVVQ  480
            F+IGGQLFRT G   V  GWK LFGK        D+ +  +LP+++ ++ C V GAE   
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  481  LMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRRFIV  540
            L T+PPA Y  +TLI+AM NAAAFVTD AL+KVLK+NAG+GTEATRAGI++ LL+R F+V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  541  RKSSKLLATDLGSDVIDSLPPQLTEPGMTALWEQALDEVAAGRMSLSDFLQRQTGWTRNL  600
            R    L +T LG +++D LP  LT+PG+TALWEQ LDEVAAGR+SL DF+ +Q+ W  +L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  601  VSQGAQQQVSIRIPPTPPCPLCGGKTRLRKGQKGDFWSCQRYPDCKGVIN  650
            V+QG  Q ++++ PP+PPCP+CGGKT  R+G+ G FW+C +YP+CKG++N
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  700 bits (2647),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 380/647 (59%), Positives = 514/647 (80%), Gaps = 0/647 (0%)

Query  1    MQLYLCEKPSQAKDIARVLGISKRGQGFISADNITVTWAIGHLLEQASPDAYGEQFGKPW  60
            M+L LCEKPSQ++DIA+ LG ++RG+GF+++  +TVTWA GHLLE A P+ YGEQ+GKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RVDVLPVLPDNWKMVVKPQTRDQFTVISKLLKQAGEVIIATDADREGEVIARELLAYCGY  120
            R DVLP+LP++WK+VVK++++ QF+VI++LLKQ +EV+IATDADREGEVIARELL YC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGAVRRLWLSALDEASIREALAGILPGENTAKLYDAGLGRSRADWLIGMNLTRLYTLIAR  180
            +G V RLW+SALD+ASIR ALA++ P+  T  LY AG+GRSRADWLIGMNLTRL+TL++R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ESGVSDVLSVGRVQTPTLAIVVNRDKEIADFVPVPWWQVQVLLEKDGVRFRATWQAAAQY  240
            E+G+++VLSVGRVQTPTLAIVV+RD+EI +FV+ P  +V   +  +GV F + W +AAQY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDDEKRCVNKQAANAVGQLCQQQKGATVLEVSQKRDKTPAPLCFDLGTLQLVCSRKFGMG  300
            CD+EKRC++   A  V QLC+Q   A++++    R K +APL F L+TLQ  CSR  GM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AKETLAVAQSLYETHKATTYPRTDCGYLPTSMQKEIPEVMGSVAKSDPSVAPVLAQLDRG  360
            A+  L +AQ LYETHK TTYPRTDCGYLP SM+ EIP+V+++V  +DP++ PV+A LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYQLIRQHYFAQFLPLQESDVTDAS  420
            FVSR+WNDKKITAHH+IIPT+++ DLS+LS  E +VYQL+R HY+AQFLP  E DVT+A+
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFLAKGKVNVITGWTCLFQKEIQEDPPEDDDMALPALNKGDSCIVNGASVGDKV  480
            FNIGGQLF ++G+V V  GW  LF K  ++D  + ++ +LPA++ G+ C V+GA      
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  481  TSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAGVLETLFSRHYLEKK  540
            T PP P+ +GTLIAAM NAA+FV+D+ LKKVL++NAG+GTEATRAG+++TL+ R +L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  541  GKHIHATLLARELIAALPETLTSPGMTALWEQALDDIAQGKMSLDTFIQKQLQWTRHLVD  600
             K + +T L+R+L+  LP TLT+PG+TALWEQ LD++A G++SLD F+ KQ QW  +LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  601  KGRADTVKITAPVTPPCPVCKGLTRKRKGKNGDFWGCIRYPECNGIV  647
            +GR++ + + AP +PPCPVC G T +R+GK+G FWGC++YPEC+GIV
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  694 bits (2626),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 394/652 (61%), Positives = 513/652 (79%), Gaps = 4/652 (0%)

Query  1    MRLFLCEKPSQGRDLAAVLGATRRGEGFLTGNGVTVTWAVGHLLETAPPEVYGQQYGKPW  60
            MRL LCEKPSQGRD+A  LGAT+RGEGFL G GVTVTWA GHLLETA PEVYG+QYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   SLSVLPILPSRWQVVVKKDTQDQFKVIEKLLRQADEVVIATDADREGEVIARELLDYCGW  120
               VLP+LP +W++VVK D++ QF VI++LL+Q DEVVIATDADREGEVIARELLDYC  
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  EGRILRLWFSALDELSVRAALSDLRPGQASVGMYHAGLGRSRADWLVGMNLSRLYTLRAA  180
            +GR++RLW SALD+ S+R+AL+DL+P+  + ++Y AG+GRSRADWL+GMNL+RL+TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGFEGVVSVGRVQTPTLALVVRRDREIAAFVPKPFWQVKAVLSASGVSFQASWVPAAVY  240
            EAG+  V+SVGRVQTPTLA+VV+RDREI  FV+KP+ +V A ++ +GV F + WVPAA Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  TDEEKRCIHQNIAQQVAQLCRQAGVATVTEYETKREKEAAPLVFSLGTLQRACGRMWNMS  300
             DEEKRCI+  +A QV QLCRQ+  A++ + +  R K++APL FSL+TLQ+AC+R W M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQQVLDTAQSLYETHKATTYPRTNCGWLPESMREEIPAVFDAMARTDPSPEFASLLSQLD  360
            +Q VLD AQ LYETHK TTYPRT+CG LP SMREEIP V+ A+  TDP+  + ++++ LD
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA--LQPVVASLD  358

Query  361  RGFVSRIWNDKKITAHHGIIPTRNAVQLSGLTETERQVYLLIRRNYLAQFLPLCESDATR  420
              FVSRIWNDKKITAHHGIIPT+++ +LS L+++ER+VY L+R +YLAQFLP  E D T 
Sbjct  359  TQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTE  418

Query  421  ISFDIGGQLFRTTGRTEVLKGWKVLFTKDEENKNAADDENAGALPPLRKGAQCGVTGAEV  480
             +F+IGGQLFRT G   V  GWK LF K  E+ +  D+    +LP+++ G  C V GAE 
Sbjct  419  ATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDE--DNTGETTLPAMQAGQVCQVQGAEQ  476

Query  481  KQLMTQPPAHFTFDTLIGAMMNAAAYVTDLQLRKILKENAGLGTEATRAGIIEQLLSRRF  540
            K L T+PPA +  +TLI+AM NAAA+VTD  L+K+LKENAG+GTEATRAGII+ LL R F
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  541  ITLKGSKLLATDLGADVIDALPAQLTDPGMTALWEQALDEVAAGRMNLNDFLQRQTAWTA  600
            +      L +T LG +++D LP+ LT+PG+TALWEQ LDEVAAGR++L+DF+ +Q+ W +
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  601  TLVSQGMQQRISIRVPPSPPCPLCGSKTALRRSPKGEFRSCTRYPECKGIIS  652
             LV+QG  Q ++++ PPSPPCP+CG+KT  R +  G F++C +YPECKGI++
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  689 bits (2604),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 382/645 (60%), Positives = 515/645 (80%), Gaps = 2/645 (0%)

Query  1    MQLFLCEKPSQAKDIARVLGISKREQGFISGGNIVVTWAVGHLLETASPEAYGEQYGRPW  60
            M+L LCEKPSQ++DIA+ LG ++R +GF++G  + VTWA GHLLETA PE YGEQYG+PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RADVLPVLPEAWKMVVKEQTKSQFTVISKLLKKASEVVIATDADREGEVIARELMEYCRY  120
            R+DVLP+LP+ WK+VVK ++K+QF+VI++LLK+  EVVIATDADREGEVIAREL++YC++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  SGAVRRLWLSALDEASVKEALSSILPGEKTALLYDAGKGRSQADWLIGMNLTRLYTLKAR  180
             G V RLW+SALD+AS++ AL+ + P+ +T  LY AG GRS+ADWLIGMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  DSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAVWVPVEQY  240
            ++G+++VLSVGRVQTPTLA+VV+RD EI +FV+KP  +V A +  +GV F + WVP  QY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCINPQAARAVGQLCQQQGRAVVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMG  300
            CDEEKRCI++  A  V QLC+Q   A +++    R K +APL F L+TLQQ CSR  GM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ANDVLAIAQSLYETHKATTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVLNQLDRK  360
            A+ VL IAQ LYETHK TTYPRTDCG+LP SM++EIP+VL+AV  +DPA+ PV+  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEAS  420
            FVSR+WNDKKITAHH+IIPT+++ DLS+LS  E +VY+L+R HY+AQFLP  E DVTEA+
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FNIGGQLFRTRGKVGVVTGWKSLFQAekdddeedvdgdSMALPALAKGDICAVTGSEVKD  480
            FNIGGQLFRTRG+V V  GWKSLF   K  ++++ + +  +LPA+  G++C V G+E K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLF--GKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  481  MKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAAVLETLFKRHYLE  540
            ++T PP P+ +GTLIAAM NAA+FV+D+ LKKVL++NAG+GTEATRA++++TL+KR +L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  541  KKGKHIHSTQMARELIAALPETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHL  600
            +  K + ST ++R+L+  LP TLT+PG+TALWEQ LD+++ G++SL  FM KQ QW  +L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  601  VEKGRQDSVKITAPVTPPCPLCKGPTrkrkgkkgDFWGCVRYPDC  645
            V +GR +++ + AP +PPCP+C G T +R+GK G FWGC++YP+C
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPEC  643

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  685 bits (2591),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 398/668 (60%), Positives = 517/668 (78%), Gaps = 8/668 (1%)

Query  1    MRLFLCEKPSQGRDLAAVLGASRRGEGFMTGNGVTVTWAVGHLLETAPPEVYGQQYGKPW  60
            MRL LCEKPSQGRD+A  LGA++RGEGF+ G GVTVTWA GHLLETA PEVYG+QYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   SLSALPILPSRWQVVVKKDTQDQFKVIEKLLRQADEVVIATDADREGEVIARELLDYCGW  120
                LP+LP +W++VVK D++ QF VI++LL+Q DEVVIATDADREGEVIARELLDYC  
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  DGRILRLWFSALDELSVRAALSDLRPGQASVGMYHAGLGRSRADWLIGMNLSRLYTLRAA  180
            +GR++RLW SALD+ S+R+AL+DL+P+  + ++Y AG+GRSRADWLIGMNL+RL+TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EAGFEGVVSVGRVQTPTLALVARRDREIAAFVPKPYWQVKATLSASGVSFQASWVPAAVY  240
            EAG+  V+SVGRVQTPTLA+V +RDREI  FV+KPY +V AT++ +GV F + WVPAA Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  ADEEKRCIHQNIAQQVAQLCRQAGVSTVTEYETKREKEAAPLAFSLGTLQRACGKMWNMS  300
             DEEKRCI+  +A QV QLCRQ+  +++ + +  R K++APLAFSL+TLQ+AC++ W M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQKVLDTAQSLYETHKATTYPRTDCGWLPKSMREEIPAVFDAMARTDPSPEFASLLSQLD  360
            +Q VLD AQ LYETHK TTYPRTDCG LP SMREEIP V+ A+  TDP+  + ++++ LD
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA--LQPVVASLD  358

Query  361  RGFASRIWNDKKITAHHGIIPTRNAVQLSSLTETERQVYLLIRRNYLAQFLPLCESDATR  420
              F SRIWNDKKITAHHGIIPT+++ +LS L+++ER+VY L+R +YLAQFLP  E D T 
Sbjct  359  TQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTE  418

Query  421  ISFDIGGQLFRTTGRTEVLKGWKVLFtkdeedkdtaeedIAGSLPPLSKGAQCGVTDAEV  480
             +F+IGGQLFRT G   V  GWK LF K  ED +        +LP++  G  C V +AE 
Sbjct  419  ATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG--ETTLPAMQAGQVCQVQGAEQ  476

Query  481  KQLMTQPPAHYTFDTLIGAMMNAAAYVTDLQLRKILKENAGLGTEATRAGIIEQLLSRRF  540
            K L T+PPA Y  +TLI+AM NAAA+VTD  L+K+LKENAG+GTEATRAGII+ LL R F
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  541  ITLKGSKLLATDLGADVIDALPPQLTDPGMTALWEQALDEVAAGRMNLNDFLQRQTAWTS  600
            +      L +T LG +++D LP  LT+PG+TALWEQ LDEVAAGR++L+DF+ +Q+ W S
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  601  TLVSQGMQQRISIRVPPSPPCPLCGSKTALRRSPKGEFRSCTRYPECKGIISLDS----G  656
             LV+QG  Q ++++ PPSPPCP+CG+KT  R +  G F++C +YPECKGI++ ++    G
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRG  656

Query  657  RRKSPARA  664
            RR+ P+ A
Sbjct  657  RRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  684 bits (2587),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 378/665 (57%), Positives = 519/665 (79%), Gaps = 2/665 (0%)

Query  1    MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPW  60
            M L LCEKPSQ+RDIA+ LG  QRG+G+L G ++TVTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRF  120
            R + LP+LP QW+  VK ++  QFAVI +LLKQ DEV+IATDADREGEVIARELL+YC+F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQ  180
             G V RLW+SALD++SIR ALA +  + +TE+L  AG+GR+RADWL+G+NLTRL+TL ++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  AQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDD  240
              G+G+VLS+GRVQTPTLA+VV+RD +I  F +KPY +V+A++  +++ F  KW+PA++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMG  300
            CDEEKRCI+ ++A  VVQ C+Q+  A + +    R K ++PL F L+ LQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDAS  360
            A  VL IAQ LYE HK TTYPRTDCGYLP+SMRE+IP V++A+  TDPA++++++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  TLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVT  420
             +SR+WND +ITAHH+IIPT+HT D++KL+  E ++YQL+R  YLAQFLP  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQD-DNTALPALKKEEICPVLRAEIQPRQ  479
            F IGGQ+F+++G V V  GWK+LF+   + +E++ ++T+LPA++  ++C V  AE +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARK  539
            T+PPAP+ +GTLIAAM NAAAF+ D+ LKKVL+ENAG+GTEATRAGII++L++R +L R 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  KKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVE  599
            KK L +TPL+++L+  LP+ LT+PG+TALWEQ LD++A GR +LD+FM KQ+QW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  KGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRR  659
            +G++QP+    P +P+CP CGG   +R GK+  FWGC +YP CKG++N N+  G+R  RR
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRR  659

Query  660  GNSPD  664
              SP 
Sbjct  660  KPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  684 bits (2587),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 378/665 (57%), Positives = 519/665 (79%), Gaps = 2/665 (0%)

Query  1    MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPW  60
            M L LCEKPSQ+RDIA+ LG  QRG+G+L G ++TVTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRF  120
            R + LP+LP QW+  VK ++  QFAVI +LLKQ DEV+IATDADREGEVIARELL+YC+F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQ  180
             G V RLW+SALD++SIR ALA +  + +TE+L  AG+GR+RADWL+G+NLTRL+TL ++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  AQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDD  240
              G+G+VLS+GRVQTPTLA+VV+RD +I  F +KPY +V+A++  +++ F  KW+PA++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMG  300
            CDEEKRCI+ ++A  VVQ C+Q+  A + +    R K ++PL F L+ LQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDAS  360
            A  VL IAQ LYE HK TTYPRTDCGYLP+SMRE+IP V++A+  TDPA++++++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  TLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVT  420
             +SR+WND +ITAHH+IIPT+HT D++KL+  E ++YQL+R  YLAQFLP  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQD-DNTALPALKKEEICPVLRAEIQPRQ  479
            F IGGQ+F+++G V V  GWK+LF+   + +E++ ++T+LPA++  ++C V  AE +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARK  539
            T+PPAP+ +GTLIAAM NAAAF+ D+ LKKVL+ENAG+GTEATRAGII++L++R +L R 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  KKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVE  599
            KK L +TPL+++L+  LP+ LT+PG+TALWEQ LD++A GR +LD+FM KQ+QW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  KGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRR  659
            +G++QP+    P +P+CP CGG   +R GK+  FWGC +YP CKG++N N+  G+R  RR
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRR  659

Query  660  GNSPD  664
              SP 
Sbjct  660  KPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  683 bits (2584),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 387/653 (60%), Positives = 518/653 (80%), Gaps = 4/653 (0%)

Query  1    MQLYLCEKPSQARDIARVLGLSGRGEGCIEGDTVTVTWAVGHLLELAAPEAYGEQFGVPW  60
            M+L LCEKPSQ+RDIA+ LG + RGEG ++G  VTVTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMESLPVLPEKWQMTVKPQTKSQFTVISRLLKRASEVVIATDADREGEVIARELLTYCRY  120
            R + LP+LP++W++ VK+++K+QF+VI+RLLK+  EVVIATDADREGEVIARELL YC++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RGPVRRLWLSALDEASVREALANILPGEQTARLYDAGLARGQADWLIGMNLTRLYTLKAR  180
            +G V RLW+SALD+AS+R ALA++ P+ +T  LY AG++R++ADWLIGMNLTRL+TL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  VSGIPDVLSVGRVQTPTLAMVVRRDQEIAGFVPRPWWQVFVGLEKDGIRFRAVWVAAEQY  240
             +GI +VLSVGRVQTPTLA+VV+RD+EI  FV++P  +V+  +  +G+ F + WV+A QY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCVNVQAARAVLQLCQQTPSAVVHEVTRKREKTPAPLCFSLGTLQEACSRKFGMG  300
            CDEEKRC++   A  V+QLC+QTP+A + +    R K +APL FSL+TLQ+ACSR  GM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQTVLNIAQSLYETHKATTYPRTDCGYLPESMQQESREVLAAMARSDPALTPVLAQLDPG  360
            AQTVL+IAQ LYETHK TTYPRTDCGYLP SM++E  +VL+A+  +DPAL PV+A LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHAIIPTRQVFDIRALSEDELKVYLLIRQHYLAQFLPLQESDITDAT  420
            FVSRIWNDKKITAHH+IIPT++  D+  LS+ E +VY L+R HYLAQFLP  E D+T+AT
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LTLGGQRFRARGKVNVVTGWRGLFSgeaaedaegedeQTTEMALPALERGEHCRISGSEL  480
            + +GGQ FR+RG+V V  GW++LF+      +E+++++T E +LPA++ G+ C++ G+E 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG----KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQ  476

Query  481  KGRMTSPPAPFTEGTLIAAMKNAASQVSDPKLKKVLRENAGLGTEATRAGVLEVLFARQY  540
            K   T PPAP+ +GTLIAAM NAA+ V+D+ LKKVL+ENAG+GTEATRAG+++ L+ R +
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  541  LEKSGKHIRSTQRGRELTAALPEALTSPGMTALWEQALDDIAQGRMSLDTFMGRQQQWVR  600
            L +  K ++ST  GR+L   LP +LT+PG+TALWEQ LD++A GR+SLD FM++Q QWV 
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  601  HLVSSGREQPFSMTVPVMPPCPLCQGPTRQRKGKHGLFRSCQRYPECKGVVNT  653
            +LV+ GR QP++M  P  PPCP+C G T QR+GK GLF++C +YPECKG+VN 
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNN  649

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  677 bits (2561),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 381/627 (61%), Positives = 496/627 (80%), Gaps = 2/627 (0%)

Query  1    MRLFICEKPSQGRDLAGVLGATRRGDGFLTGSGVTVTWAVGHLLETAPPEAYGQQYGKPW  60
            MRL +CEKPSQGRD+A  LGAT+RG+GFL G+GVTVTWA GHLLETA PE YG+QYGKPW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   SLSALPILPAPWRVVVKKETQDQFKVIERLLRQVDDVVIATDADREGEVIARELLEYCRW  120
                LP+LP  W++VVK +++ QF VI+RLL+QVD+VVIATDADREGEVIARELL+YC+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  EGPVQRLWLSALDELSIRAALQDLRPGQATLGMYHAGLGRARADWLIGMNLSRLYTLRAA  180
            +G V RLW+SALD+ SIR+AL DL+P+  T ++Y AG+GR+RADWLIGMNL+RL+TL + 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ESGFDGVVSVGRVQTPTLALVVRRDREIAAFVPKPFWQVKALISAGDLTFPAQWVPAKVY  240
            E+G++ V+SVGRVQTPTLA+VV+RDREI  FV+KP+ +V A ++  ++ FP++WVPA  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  TDEEKRCVHQNIAQQVAQLCRQTGHAVVTECDTKREKAAAPLAFSLGSLQQACGRLWDMS  300
             DEEKRC++  +A QV QLCRQT  A + +C+  R K +APLAFSL++LQQAC+R W+M+
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  PQQVLDTAQSLYEKHKATTYPRTDCGYLPESMREEISGVLDAIGRTDPECAPVLARLDRT  360
            +Q VLD AQ LYE HK TTYPRTDCGYLP SMREEI+ VL A+  TDP   PV+A LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  FVSRIWNDKKITAHHGIIPTRNAFQLSALTETERNVYMLIRRNYLAQFLPLHESDFTRLQ  420
            FVSRIWNDKKITAHHGIIPT+++ +LS L+++ERNVY L+R +YLAQFLP  E D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FDTGGQLFRATGRTEVIKGWKVLFENAGDNEVDDGDEADIALPPLAQNDRCAVTGAEVVQ  480
            F+ GGQLFR+ G   V  GWK LF + +++  D+++ ++ +LP++   + C V GAE   
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSED--DEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  481  LMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRHFIV  540
            L T+PPA Y  +TLI+AM NAAAFVTD AL+KVLK+NAG+GTEATRAGI++ LL+R F+V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  541  RKGSKIMATELGADVIDALPPQLTEPGMTALWEQALDEVAAGRMSLDDFLQRQTGWTRNL  600
            R    + +T LG +++D LP  LT+PG+TALWEQ LDEVAAGR+SLDDF+ +Q+ W  +L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  601  VSQGTQQQVRIRVPPTPACPLCGGKPV  627
            V+QG  Q + ++ PP+P+CP+CGGK +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTL  625

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  662 bits (2504),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 379/665 (57%), Positives = 515/665 (78%), Gaps = 2/665 (0%)

Query  1    MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPW  60
            M L LCEKPSQ+RDIA+ LG  QRG+G+L G ++ VTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRF  120
            R + LP+LP QW+  VK ++  QFAVI +LLKQ DEV+IATDADREGEVIARELL+YC+F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVRRLWLSALDETSIRQALAAILPGEKTESLWQAGLGRARADWLMGINLTRLYTLKAQ  180
             G V RLW+SALD++SIR ALA + P+ +TESL  AG+GR+RADWL+G+NLTRL+TL ++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  AQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVVATLQKDGIGFRVKWLPAPDD  240
              G+G+VLS+GRVQTPTLA+VV+RD +I  F +KPY +V+AT+  +G+ F  KW+PA++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDEEKRCIKEDIAHSVVQCCQEAQNAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMG  300
            CDEEKRCI+ ++A  VVQ C+++  A + +    R K ++PL F L+ LQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDAS  360
            A  VL IAQ LYE HK TTYPRTDCGYLP+SMRE+IP V++A+  TDPA++++++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  TLSRVWNDSQITAHHAIIPTRHPFDMTKLTADELKVYQLIRQYYLAQFLPAQETDVTDVT  420
             +SR+WND +ITAHH+IIPT+H  D++KL+  E +VYQL+R  YLAQFLP  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FTIGGQVFQATGRVSVVTGWKALFADEKQAQDQD-GNTALPVLKKAETCPVIRAEIQPRQ  479
            F IGGQ+F++ G V V  GWK+LF+   + ++++ G+T+LP ++ ++ C V  AE +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEalfkrrllark  539
            T+PPAP+ +GTLIAAM NAAAF+ D+ LKKVL+ENAG+GTEATRAGII++L+KR +L R 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  kknlhaTQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVE  599
            KK L +T L+++L+  LP+ LT+PG+TALWEQ LD++A GR +LD+FM KQ+QW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  KGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRR  659
            +G++QP+    P +P+CP CGG   +R GK+  FWGC +YP CKG++N N+  G+R  RR
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRR  659

Query  660  GNSPD  664
              SP 
Sbjct  660  KPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  661 bits (2497),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 375/660 (57%), Positives = 502/660 (77%), Gaps = 8/660 (1%)

Query  1    MKLFLCEKPSQAKDIARVIGAHQRRDNFFQGNGVQVAWARGHLLEQAEPEAYGAQFAAPW  60
            M+L LCEKPSQ++DIA+ +GA QR + F++G GV V+WARGHLLE AEPE YG Q++ PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLEACHY  120
            R   LP++P+QWK+VVK DA + F  I++LL Q  EVVIATDADREGEVIARELL+ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  RKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRLFTLKAR  180
            + +V RLW+SALD+ASIR AL +L P+ +T SLY AG+GR+RADWLIGMN+TRLFTL +R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  ELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGIIFQAHWRPASQY  240
            E G+G +LSVGRVQTPTLA++V+R+REI +FVSKP+  V A++  +G++F + W PA+QY
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  CDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQQAASRRWGYS  300
            CD+E RCI+   A  V QLCRQ+  A++   +  + K  +PL+F L+TLQQA SR+WG +
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  ADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPALQNVLAQLQPA  360
            A+ VL+IAQ LYE HK TTYPRTDCGYLP+SMR +IP VL A+  +DPALQ V+A L+  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  RISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQFLPDQEWDATEVF  420
             +SR+WND KITAHH+IIPT++T DL+ +++AE NVY+L+R HYLAQFLP+ E D TE  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKeeaetgleagtetlPSLHEGEFCVVQ  480
            ++IGGQ F ++G+V    GW  LF K  +D           ++G  TLP+++ G+ C VQ
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSED--------DEDNTGETTLPAMQAGQVCQVQ  472

Query  481  EAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLGTEATRAGIITTLE  540
             A    L T PP PY DGTLIAAM NA++F+TD++LKKVLKENAG+GTEATRAGII TL 
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  541  NRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQGNLSLDVFMQKQI  600
            +R ++VR+KKTL++T  G +L+D LP++ T+PG+TALWEQ L++VA G +SLD FM KQ 
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  601  SWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPDCKGSVPLPEK  660
             W+++L+ +G   PL+++ PP P+CP C GK + R++  G FW+C +YP+CKG V   +K
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNK  652

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  653 bits (2470),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 377/665 (57%), Positives = 513/665 (78%), Gaps = 2/665 (0%)

Query  1    MQLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPW  60
            M+L LCEKPSQ+RDIA+ LG  QRG+G+L G ++ VTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCHF  120
            R + LP+LP QW+  VK ++  QFAVI +LLKQ DEV+IATDADREGEVIARELL+YC F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVRRLWLSALDETSIRQALAAILPGEKTAPLWQAGLGRARADWLTGINLTRLYTLKAQ  180
             G V RLW+SALD++SIR ALA + P+ +T +L  AG+GR+RADWL G+NLTRL+TL ++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  AQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMATLQKDDISFRAKWLPAPDD  240
              G+G+VLS+GRVQTPTLA+VV+RD +I  F +KPY +V+AT+  +++ F +KW+PA++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  GDEEKRCIREDIAQSVVQRCQQTQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMG  300
             DEEKRCI+ ++A  VVQ C+QT  A + +    R K ++PL F L+ LQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDAS  360
            A  VL IAQ LYETHK TTYPRTDCGYLP+SMRE+IP V++A+  TDPA+ ++++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  AFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVT  420
              SR+WND +ITAH +IIPT+HT D++KL+  E +VYQL+R  YLAQFLP  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQE-DNTALPALKKEEISPVLRAEIQPRQ  479
            F IGGQ+F+++G V V  GWK+LF+   + +E++ ++T+LPA++  ++  V  AE +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEalfkrrllark  539
            T+PPAP+ +GTLIAAM NAAAF+ D+ LKKVL+E+AG+GTEATRAGII++L+KR +L R 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  kknlhaTQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVE  599
            KK L +T L+++L+  LP+ LT+PG+TALWEQ LD++A GR +LD+FM KQ+QW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  KGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRR  659
            +G++QP+    P +P+CP CGG   +R GK+  FWGC +YP CKG++N N+  G+R  RR
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRR  659

Query  660  GNSPD  664
              SP 
Sbjct  660  KPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  641 bits (2422),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 381/665 (58%), Positives = 517/665 (78%), Gaps = 2/665 (0%)

Query  1    MPLYLCEKPSQARDIARVLGVKQRGQGYLFGGSITVTWAIGHLLEMAAPEHYGEQFGPPW  60
            M L LCEKPSQ+RDIA+ LG  QRG+G+L G ++TVTWA GHLLE A PE YGEQ+G PW
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  61   RMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRF  120
            R + LP+LP QW+  VK ++  QFAVI +LLKQ DEV+IATDADREGEVIARELL+YC+F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  121  TGPVRRLWLSALDETSIRQALAAILPGEQTESLWQAGLGRARADWLTGINLTRLYTLKAQ  180
             G V RLW+SALD++SIR ALA + P+ +TESL  AG+GR+RADWL G+NLTRL+TL ++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  181  EQGFGEVLSIGRVQTPTLALVVNRDNDIARFEQKPYWQVMATLQKDDISFRAKWLPAPDD  240
            E G+G+VLS+GRVQTPTLA+VV+RD +I  F  KPY +V+AT+  +++ F +KW+PA++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  241  GDEEKRCIREDIaqrvvqrcqqaqdavvTELTQKREKTPPPLCFDLGTLQQVASRQWGMG  300
             DEEKRCI+ ++A +VVQ C+Q+  A + +    R K ++PL F L+TLQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDAS  360
            A  VL IAQ LYETHK TTYPRTDCGYLP+SMRE+IP V++A+  TDPA+ ++++ LD+ 
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  AFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVT  420
              SR+WND +ITAH +IIPT+HT D++KL+  E +VYQL+R  YLAQFLP  E DVT+ T
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  FTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQE-DNTALPALKKEEISPVLRAEIQPRQ  479
            F IGGQ+F+++G V V  GWK+LF+   + +E++ ++T+LPA++  ++  V  AE +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEalfkrrllark  539
            T+PPAP+ +GTLIAAM NAAAF+ D+ LKKVL+E+AG+GTEATRAGII++L+KR +L R 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  kknlhaTQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVE  599
            KK L +T L+++L+  LP+ LT+PG+TALWEQ LD++A GR +LD+FM KQ+QW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  KGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRR  659
            +G++QP+    P +P+CP CGG   +R GK+  FWGC +YP CKG++N N+  G+R  RR
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRR  659

Query  660  GNSPD  664
              SP 
Sbjct  660  KPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  606 bits (2290),  Expect = 1e-174, Method: Compositional matrix adjust.
 Identities = 337/656 (52%), Positives = 487/656 (75%), Gaps = 1/656 (0%)

Query  1    MRLFLCEKPSQGRDIAKVLGATRRGDGCLIGTDSTVTWCIGHLLETAPPEAYGAQY-KSW  59
            MRL LCEKPSQGRDIAK LGAT+RG+G L G + TVTW  GHLLETA PE YG QY K+W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDHLPIIPAQWQVEVKSKTAAQFKIIKRLLSEASSVVIATDADREGEMIARELLELCRY  119
              D LP++P QW++ VK+ + AQF +I+RLL +   VVIATDADREGE+IARELL+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVLRLWLSALNEASIRKALSSLKSGQVTFPLYHSALARSRADWLIGMNLSRLFTLLGR  179
            +G V+RLW+SAL++ASIR AL+ L ++  T +LY ++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RAGYDGVLSVGRVQTPTLRLVVDRDRAIASFVPVPYWTVDVHLSSMGQRFIASWLPPRSG  239
             AG + VLSVGRVQTPTL +VV RDR I +FV+ PY  V   ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  RDEAGRCLQQALAHHAVQTITGEKSATVLSLQTEQLREPPPLPFDLSTLQEVCSRKLGLG  299
             DE  RC+Q ++A + VQ      +A++++ Q E+ ++++PL+F LSTLQ+ CSR  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLNIAQALYETHKATTYPRSDCRYLPESMFNEAPAVLDALLKTDPALRPAFGSLDRS  359
             Q  L+IAQ LYETHK TTYPR+DC YLP SM +E P VL A++ TDPAL+P  +SLD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  LRARVWNNAKVTAHHGIIPTTEPANLVRMSEQERQVYELIRSHYLAQFLPHHEFDRTQVE  419
            + +R+WN+ K+TAHHGIIPT + ++L ++S+ ER+VY+L+R HYLAQFLP+ E+D T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LECSKERLTAVGKQILIQGWKGLLTENTEDDEPSQKHQVLPVLQQGTQCAVNDVELKSMR  479
            ++ + + + + G+ ++  GWK+L+   +EDDE +  +  LP +Q G  C V++ E K ++
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TVAPKPLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLVDRGYLLKK  539
            T +P P  +G LI AM N A +V D+ LK+ L++ +GIGTEATRAGII  L+ RG+L++ 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  KRALMASAAAHTLIEAAPTAVADPGMTAIWEQALDEIEAGRLTLDAFVAKQANWIAQLVA  599
            K++L +++ ++ L++  P ++++PG+TA+WEQ LDE+ AGR++LD F+AKQ++W++QLVA
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  HYRSHTLAIAVETSPSCPMCNASMLRRKGKSGPFWSCSCYPDCKGTVSISKDTRRS  655
            + RS+ L++    SP+CP+C +  L+R+GKSG FW+C  YP+CKG V+ ++   R+
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRG  656

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  602 bits (2275),  Expect = 2e-173, Method: Compositional matrix adjust.
 Identities = 332/667 (50%), Positives = 495/667 (75%), Gaps = 6/667 (0%)

Query  1    MKLFLCEKPSQGKDIGRVLGATQRGKGCLTGSGITITWCIGHLVEAAPPDAYGEQY-KRW  59
            M+L LCEKPSQG+DI++ LGATQRG G L G+G+T+TW  GHL+E+A P+ YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPERWRVDVKSKTASQFNVVKDLLSKASELVIATDADREGELIAREIIELCGY  119
              + LP++P++W++ VK+ + +QF V++ LL +  E+VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALATLRPSSETLPMYFSALARSRADWLIGMNLSRLFTVMGR  179
            +G + RLW+SAL+DASIR ALA L+PSS T ++Y+++++RSRADWLIGMNL+RLFT++GR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIACFVSVPFWAVETTLSSEGQSFTAAWLAPDTA  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS P+  V +T++ +G  F + W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQESIARQAVERMRSAGSAQITSVETERMREGPPLPFDLGTLQEICSKQLGLD  299
             D+  RC+Q ++A Q V+  R + +A I + + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPDSMFAEVPTVLDSLLKTDPGLRPLVDQLDRN  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+V  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLKAMNDKERAVYMLIRAHYLAQFLPQHEFDRTTAR  419
              SR WND K+TAHHGIIPT + ++L  ++D ER VY L+R HYLAQFLPQ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCAGETLQAVGKQVVVIGWRQVLAEPRPDDDGETTPRSQVLPALHEGLSCQITGIDCKA  479
            ++ +G+ +++ G+ +V  GW+ +++    DD+++T   +  LPA++ G  CQ+ G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTSPPRPYTQGELVKAMKGVAKLVADPRLKQKLKDTTGIGTEATRANIIKGLLDRGYLQ  539
            L+T PP PY +G L+ AM   A +V+D+ LK+ LK+ +GIGTEATRA II  LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSVRASDAAFTLIDVVPGAIADPGMTAIWEQALDMIEAGQLTLDVFIDKQSAWITQL  599
            +  ++++++  +  L+DV+PG++++PG+TA+WEQ LD + AG+++LD F+ KQS W++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VQQYQGASLSIKVPQGPACPECGTAMRQRTGKSGPFWSCPRYPDCKGSQPIDNGKHKRAM  659
            V Q ++ +L+++ P +P+CP CG    QR GKSG FW+C +YP+CKG   I N  +K + 
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNNGNKGPR  655

Query  660  PRKRNSS  666
             R+R++S
Sbjct  656  GRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  600 bits (2268),  Expect = 6e-173, Method: Compositional matrix adjust.
 Identities = 350/662 (53%), Positives = 493/662 (75%), Gaps = 13/662 (1%)

Query  1    MKLILCEKPSQGRDIGKFIGATKRGEGYLSSPDQQTFVTWGIGHLVEQAEPQDYDESY-K  59
            M+L+LCEKPSQGRDI+KF+GAT+RGEG+L++P+    VTW+ GHL+E AEP+ Y+E Y K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVT--VTWARGHLLETAEPEVYGEQYGK  58

Query  60   KWIFDNLPIIPDKWIMKVKKETAKQYKIVMGLIKKANHIVIATDPDREGEVIARELLDMA  119
             W  D LP++P++W + VK ++  Q+ ++  L+K+ +++VIATD+DREGEVIARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NYKGKVQRLWLSALDDGSIRKALANLKSDAETKPLYAAGLARGRADWLVGMNLTRLFTLI  179
            +++G+V RLW+SALDD+SIR ALA+L + + T +LY AG++R+RADWL+GMNLTRLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQKQGYQGVMSVGRVQSPTLAIVVQRDREIENFVSKPFYRLKVNLDG----FCAYWQPTE  235
            ++  G   V+SVGRVQ+PTLAIVV+RDREI+NFVSKP++ +   +      F + W P+ 
Sbjct  179  GREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAA  238

Query  236  SVCDDEGRCIDYSVITQVQR--QLSKTLKIDNIETKRKKEMPPLAFDLGTLQQTCSRLFG  293
              CD+E RCI+ +V +QV +  + + T  I N +  RKK+ +PLAF L+TLQQ+CSR  G
Sbjct  239  QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWG  298

Query  294  MGAAQVLKIAQSLYETHKATTYPRTDCGYLPESMIDEIPLVLKAVSESDPQVRNIVAKLD  353
            M A  VL IAQ LYETHK TTYPRTDCGYLP SM +EIP VL AV  +DP ++ +VA LD
Sbjct  299  MPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLD  358

Query  354  ISLRSRVWNDSKITAHHGIIPTTQKVDLSKMSDDELKVYQLVRKHYFAQFLPLYEEDNTS  413
              + SR+WND KITAHHGIIPT +  DLSK+SD E +VYQLVR HY+AQFLP  E D T 
Sbjct  359  TQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTE  418

Query  414  VLLSGNEQTFVSKGKQVIKIGWKSLF---QQDRNEDDEEQSLPSLRQGQSCNVVDSEVLT  470
              ++   Q F ++G+ ++K GWKSLF    +D +++  E +LP+++ GQ C+V ++E   
Sbjct  419  ATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  471  LKTTPPKHYTEGTLIAAMKNAARFVTDARLKQRLRETEGLGTEATRAEVIETLFKRGYLE  530
            L+T PP  Y +GTLIAAM NAA FVTDA LK+ L+E  G+GTEATRA +I+TL+KRG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  531  KKRKEIVATSAGRSLIDGLPDIIKDPGMTALWEQALNDIASGKMLLQDFMAKQNQFISHV  590
            + +K + +T+ GR+L+D LP+ + +PG+TALWEQ L+++A+G++ L+DFMAKQ+Q +S++
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  591  VKSMIGSGSVAIQVKAEKICPKCGAAMRRRKGKNGDFWGCSNYPTCTAIENIGSRKRVGK  650
            V +   S ++++Q  +   CP CG+   +R+GK+G FWGC +YP C +I N G++   G+
Sbjct  599  V-AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGR  657

Query  651  SR  652
             R
Sbjct  658  RR  659

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  598 bits (2257),  Expect = 4e-172, Method: Compositional matrix adjust.
 Identities = 338/650 (52%), Positives = 485/650 (75%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGARQRGNGCYSGSGITVTWCIGHLVEAAPPETYGEQY-KQW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+G+TVTW  GHL+E+A PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPILPERWRIEVKAKTAAQFKIVKQFVAQAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++ VKA + AQF ++++++ Q +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALTQLKPGGETLPLYFSALARSRADWLIGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR AL++L P++ T +LY+++++RSRADWLIGMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RSGYQGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWTIDVTLSHAGQSFAASWMPPDGT  239
             +G   VLSVGRVQTPTL +VV RDREI  FVS PY  +  T++  G  F++ W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPVAQQAADRIRAGRESKVLSVETERVREAAPLPFDLGTLQEVCSRQLGLD  299
             D   RC+Q  VA Q  +  R    + +++ + ER +++APL+F L+TLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQSLYETHKATTYPRSDSGYLPESMLAEVPTVLDALLATDPGLRPLIDRLDRT  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL A+++TDP+L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRVWNDSKITAHHGIIPTLEPANLSAMSEKELAVYALIRAHYLAQFLPHHEFDRTLVM  419
              SR+WND KITAHHGIIPT + ++LS +S+ E  VY L+R HYLAQFLP+ E+D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LDCAGQSLQAVGKRVIVPGWHLALPGKGQDAADDEPAQRSQILPPLDTGARCGVQQVELK  479
            ++ +GQ +++ G+ ++ PGW  +L GK  +  +D+ ++ +  LP++++G  C VQ  E K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWK-SLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKGVAKLVTDPRLKQKLKETTGIGTEATRAGIINGLLARGYL  539
             L+T PP PY +G LI AM   A +VTD+ LK+ LKE +GIGTEATRAGII+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAIRASDAAFTLIDAVPAAITDPGTTAIWEQALDMIEAGQMTLDTFINKQSAWVAQ  599
            V+  ++++++  +  L+D +P+++T+PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGTVLSIKLPEGPACPVCGAATRQRNGKNGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ P +P+CPVCG+ T QRNGK+G FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  598 bits (2257),  Expect = 5e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 498/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGQLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL++L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  597 bits (2254),  Expect = 7e-172, Method: Compositional matrix adjust.
 Identities = 332/673 (50%), Positives = 497/673 (74%), Gaps = 12/673 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T S+Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  ++   G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC++  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAK  419
              SR WND K+TAHHGIIPT + + LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVA  479
            F+ GGQ + + G+ +V PGW+ +++    +D D  G+T        +LP +  G  CQV 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQVQ  472

Query  480  DVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLI  539
            + + K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+
Sbjct  473  GAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLL  532

Query  540  ARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQA  599
             RG+LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+
Sbjct  533  KRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  600  AWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESG  659
             W+SQL+AQ  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   + + 
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNN  649

Query  660  SSKRGASRPRRSG  672
            ++K   +R R+++
Sbjct  650  GNKGPRGRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  596 bits (2253),  Expect = 9e-172, Method: Compositional matrix adjust.
 Identities = 332/650 (52%), Positives = 475/650 (74%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGYYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G+ +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  HGPIQRLWLSALNDASIRKALGALKPSAETLPLYYSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LYY++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAVDVLLSHAGRSFTASWIPPEGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS PY  V   ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPVAQQAADCIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLD  299
             D   RC+Q  VA Q  +  R +  A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAKVPAVLDALLATDPSLRPLIGQLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM   +P VL A+++TDP+L+P+++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K+TAHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLPPTPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  595 bits (2249),  Expect = 2e-171, Method: Compositional matrix adjust.
 Identities = 321/667 (49%), Positives = 490/667 (74%), Gaps = 5/667 (0%)

Query  1    MRLFLCEKPSQGKDIGRVLGTTQRGNGCLTGSGITVTWCIGHLVEAAPPETYGEQY-KRW  59
            MRL LCEKPSQG+DI++ LG+TQRG+G L G+G+TVTW  GHL+E+A PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPECWRVEVKSKTASQFNVVKELLSKATELVIATDADREGELIAREIIELCGY  119
              + LP++P+ W++ VK+ + +QF V++ LL +  E+VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDTSIRKALSVLRPSDETLPMYFSALARSRADWLIGMNLSRLFTVLGR  179
            +G + RLW+SAL+D+SIR AL+ L+PS  T ++Y+++++RSRADWLIGMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWAVEVVLSSAGQHFTAAWLAPDTA  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS P+  V   ++  G  F + W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  ADNAGRCLQEPIARQATERMRVTGSAQVTSVETEHMREGPPLPFDLGTLQEVCSRQLGLD  299
             D+  RC+Q  +A Q  +  R T +A + + + E+ ++++PL+F L+TLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPIVFDSLLKTDPDLRPIVDLLDRN  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P V+ +++ TDP L+P+V  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLAAMSDKERAVYTLIRTHYLAQFLPHHEFDHTTAY  419
              SR WND K+TAHHGIIPT + ++L+ +SD ER VY L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCAGEMLQAVGKQVVLVGWRRVLTEPKPDDDGDTTSRSQVLPPLNEGLSCQITGIDCKA  479
            ++ +G+++++ G+ +V  GW+ ++     DD+++T   +  LP+++ G  CQ+ G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTSPPRPYTQGELVKSMKSVAKLVSDPRLKQTLKDTTGIGTEATRANIIKGLLDRGYLL  539
            L+T PP PY +G L+ +M + A +V+D+ LK+ LK+ +GIGTEATRA II  LL RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIESGQLTLDVFIDKQSAWIAQL  599
            +  ++++++  +  L+D +PG++++PG+TA+WEQ LD + +G+++LD F+ KQS W++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IQQYRGASLSIQMPLGPACPECGTPMHQRPGKNGAFWSCPRYPDCRGSLPIDSGKRKRTT  659
            + Q R+ +L++Q P +P+CP CG    QR GK+G FW+C +YP+C+G   +++G++    
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNKGPRG  656

Query  660  PRKRNSS  666
             R++ S+
Sbjct  657  RRRKPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  594 bits (2244),  Expect = 4e-171, Method: Compositional matrix adjust.
 Identities = 325/663 (50%), Positives = 486/663 (74%), Gaps = 4/663 (0%)

Query  1    MCEKPSQGKDIGRVLGATQRGNGCLAGSGITVTWCIGHLVEAAPPETYGEQY-KRWSIEQ  59
            +CEKPSQG+DI++ LGATQRG+G L G+G+TVTW  GHL+E+A PE YGEQY K W  + 
Sbjct  5    LCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDV  64

Query  60   LPIIPERWRVEVKSKTASQFNVVKNLLSKATELVIATDADREGELIAREIIELCGYHGPI  119
            LP++P++W++ VK+ + +QF V++ LL +  E+VIATDADREGE+IARE+++ C ++G +
Sbjct  65   LPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRV  124

Query  120  QRLWLSALNDASIRKALAALRPSGETLPMYFSALARSRADWLIGMNLSRLFTVMGRQAGY  179
             RLW+SAL+DASIR ALA L+PS+ T ++Y+++++RSRADWLIGMNL+RLFT++GR+AG 
Sbjct  125  FRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGI  184

Query  180  DGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTVETVLSSAGQSFTAGWLAPDTATDDA  239
            + VLSVGRVQTPTL +VV RDREI  FVS P+  V + ++  G  F + W+++    D+ 
Sbjct  185  GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEE  244

Query  240  GRCLQEPIARQAAERMRIAGSAQVTSVETERLREGPPLPFDLGTLQEICSKQLGLDVQET  299
             RC+Q  +A Q  +  R + +A + + + ER ++++PL+F L+TLQ+ CS++ G+  Q  
Sbjct  245  KRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTV  304

Query  300  LEIAQALYETHKATTYPRSDSGYLPESMFAEVPVVLDSLLKTDPGLRPIVDQLDRNQRSR  359
            L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+V  LD +  SR
Sbjct  305  LDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSR  364

Query  360  AWNDSKVTAHHGIIPTLEPANLTAMSDKEQAVYKLIRAHYLAQFLPQHEFDRTTACLSCT  419
             WND K+TAHHGIIPT + ++L+ +SD E+ VY+L+R HYLAQFLPQ E+D T A ++  
Sbjct  365  IWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIG  424

Query  420  GETLQAVGKQIVVIGWRQVLTEPRPDEDGETTLRSQVLPALHEGLSCQITGIDCKALKTS  479
            G+ +++ G+ +V  GW+ ++     D++++T      LPA++ G  CQ+ G + K L+T 
Sbjct  425  GQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG--ETTLPAMQAGQVCQVQGAEQKVLQTK  482

Query  480  PPRPYTQGELVKAMKGVAKLVSDPRLKQKLKDTTGIGTEATRANIIKGLLDRGYLLKKSR  539
            PP PY +G L+ AM   A +V+D+ LK+ LK+ +GIGTEATRA II  LL RG+L++  +
Sbjct  483  PPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKK  542

Query  540  SVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIEAGQLTLDVFIDKQSAWITQLVQQY  599
            +++++  +  L+D +PG++++PG+TA+WEQ LD + AG+++LD F+ KQS W++QLV Q 
Sbjct  543  TLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQG  602

Query  600  RGASLSIKVPQGPACPECGTAMRQRTGKSGPFWSCPRYPDCKGSQPIDSGKHKRAMPRKR  659
            R+ +L+++ P +P+CP CG    QR GKSG FW+C +YP+CKG    ++ K  R+  RK 
Sbjct  603  RSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRRKP  661

Query  660  SRS  662
            S +
Sbjct  662  SPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  592 bits (2236),  Expect = 2e-170, Method: Compositional matrix adjust.
 Identities = 338/677 (50%), Positives = 488/677 (73%), Gaps = 14/677 (2%)

Query  1    MRVVLCEKPSQGKDIARVLGAHRREAGCLGGPGITVTWGSGHLIEAAPPEAYGEHFQR-W  59
            MR+VLCEKPSQG+DIA+ LGA +R  G L GPG+TVTW+ GHL+E+A PE YGE++ + W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   TLETLPIVPPRWQWVVKARSAAQFKVVKRLLGEASELIIATDADREGEMIAREMIDYCGY  119
              + LP++P +W+ VVKA + AQF V++RLL +  E++IATDADREGE+IARE++DYC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALNDASIRKAFGALRASSETLSLYHCALARSRADWLVGINLTRLFTLLGR  179
            +G V RLW+SAL+DASIR A++ L++SS T SLY  +++RSRADWL+G+NLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  HAGHDGVLSVGRVQTPTLKLVVDRDREIAAFVPVPFWSIDVSLSAANVPFSAHWLAPRTA  239
            +AG + VLSVGRVQTPTL +VV RDREI  FV+ P+  +  +++   V F++ W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLRQSVarhaadairaagtaQVVHTETERVREGPPLPFDLSTLQEVCSRRLGLE  299
             D+  RC++ +VA +  +  R + TA +++ + ER ++++PL+F LSTLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRTDAGYLPENMLAEVPTVIQSLVKTDPALQPLIDRLDFR  359
             Q  LDIAQ LYETHK TTYPRTD GYLP +M  E+P V+ ++V TDPALQP++  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKITAHHAIIPTLEPADISAMSAKELAVYRLIRAHYLAQFLPHHEFDRTVVR  419
              SR WND KITAHH+IIPT + +D+S +S  E  VY+L+R HYLAQFLP+ E+D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FRCGGETLQAVGKRIAVPGWQHAFSAPSLPHVAADGADTEGSDEAPREQMLPVLQEGISC  479
            F  GG+ +++ G+ +  PGW+  F           G  +E+ ++   E  LP +Q G  C
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLF-----------GKMSEDDEDNTGETTLPAMQAGQVC  469

Query  480  QVSALDLKSLSTKPPRPYTQGELVKAMKTVARLVTDPRLKQKLKDTTGIGTEATRANIIS  539
            QV + + K L TKPP PY +G L+ AM   A +VTD+ LK+ LK+ +GIGTEATRA II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  540  GLLSRGFLIRKGRAVRASDTAMMLIDAVPAAIADPGTTAIWEQALDMIEARQMGLESFVE  599
             LL RGFL+R  ++++++  +  L+D +P+++++PG TA+WEQ LD + A +++L+ F+ 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  600  KQAAWVTQLVRQHLGTTLAIRSPEGPPCPLCGAATRQRTGRSGPFWSCSRYPDCKGTAPV  659
            KQ+ WV+QLV Q  +  L++++P +PPCP+CG+ T QR G+SG FW+C +YP+CKG   V
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--V  647

Query  660  APAQAGPDGQKRSRSRG  676
              ++ GP G++R  S +
Sbjct  648  NNGNKGPRGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  590 bits (2228),  Expect = 9e-170, Method: Compositional matrix adjust.
 Identities = 346/669 (52%), Positives = 494/669 (74%), Gaps = 7/669 (1%)

Query  1    MRVVLCEKPSQGKDIARVLGATQRGNGCYTGSGLGVTWGIGHLIETAPPEAYGEQY-KRW  59
            MR+VLCEKPSQG+DIA+ LGATQRG+G   G+G+ VTW+ GHL+ETA PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   ALEPLPIIPQHWQVVVKAKTATQFKVVKQLLAQATDLVIATDADREGEMIARELIDYCGY  119
              + LP++PQ+W++VVKA + +QF V+++LL Q  ++VIATDADREGE+IAREL+DYC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSGETLPLYYSALARSRADWLIGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LYY++++RSRADWLIGMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYSGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTIEVLLAHAGQSFVANWTPPAGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS P+  +   +A  G  F ++W P+A  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQQPVAQQADERMRAAVSAQVVSVETERMREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  +  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQSLYETHKATTYPRSDSGYLPENMLAEVPTVLDSLVKTDPSLRPLVAKLDPH  359
             Q  LDIAQ LYETHK TTYPR+D GYLP +M  E+P VL ++V TDP+L+P+VA LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKVTAHHGIIPTLEPANLSALNDKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K+TAHHGIIPT + ++LS L+D E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FACAGQSLTVVGKQIVVTGWRQVLaapapdepdedaQRSQVLPALHAGLSCPIGAVDLKA  479
            F  +GQ +   G+ +V  GW+ +++  + D+ D+ ++ +  LPA++AG  C + + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIINgllgrgyll  539
            L+T PP PY +G L+ AM   A +VTD+ LK+ LK+ +GIGTEATRA II+ LL RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  kkgrAIRASDAAFTLIDAVPPAIADPGTTAVWEQALDMIEARQMTLDAFIAKQSAWVAQL  599
            +  ++++++  +  L+D +P ++++PG TA+WEQ LD + A +++LD F+AKQS WV+QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VQQYRTATLSIQLPPAPACPQCGSPMRQRTGKSGAFWSCSRYPDCKGTMAIESATGGKRS  659
            V Q R+  L++Q PP+P+CP CG+   QR GKSG FW+C +YP+CKG +      G K +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV----NNGNKGP  654

Query  660  APRKRRTAP  668
              R+R+ +P
Sbjct  655  RGRRRKPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  589 bits (2223),  Expect = 2e-169, Method: Compositional matrix adjust.
 Identities = 333/648 (52%), Positives = 489/648 (76%), Gaps = 2/648 (0%)

Query  1    MRLFLCEKPSQGRDIAKVLGASRRGDGCLIGRETTVTWCIGHLLETAPPEAYGDQY-KTW  59
            MRL LCEKPSQGRDIAK LGA++RG+G L G   TVTW  GHLLETA PE YG+QY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDHLPIIPAQWRVEVKPKTVAQFKIIKHLLSEATTVVIATDADREGEMIARELLELCNY  119
              D LP++P QW++ VK+ + AQF +I++LL +   VVIATDADREGE+IARELL+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGSVERLWLSALNEASIRKALSSLKSSQETFPLYHSALARSRADWLIGMNLSRLFTLLGR  179
            +G V RLW+SAL++ASIR AL+ L +S  T +LY ++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RAGYGAVLSVGRVQTPTLRLVVERDRAIASFVSVPYWVVNAHLSSMGQQPFIASWIPPSS  239
             AG G VLSVGRVQTPTL +VV RDR I +FVS PY  V A ++  G   F + W+P++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL-FPSKWVPAAQ  239

Query  240  GRDEAGRClqqalasqalqaisssKTATVVSLRTEHLREAPPLPFDLSTLQEVCSRKLGL  299
              DE  RC+Q ++A+Q +Q    + TA++++ + E+ ++++PL+F LSTLQ+ CSR  G+
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  300  GAQETLNIAQALYETHKATSYPRSDCRYLPESMFNEVAAVFDALLRMDPALRPALGSIDQ  359
             AQ  L+IAQ LYETHK T+YPR+DC YLP SM +E++ V+ A++  DPAL+P ++S+D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  360  SLRSRAWNDAKVTAHHGIIPTTEPANLGRMSEQERQVYELIRSHYLAQFLPHHEFDRTEV  419
             + SR WND K+TAHHGIIPT + ++L+++S+ ER+VY+L+R HYLAQFLP+ E+D TE 
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  420  ELECSAERLTAVGKQILVQGWKGLLSDNPDDDEPSQKSQVLPALQQGRQCAVDDVELKSM  479
             ++ +++ + + G+ ++  GWK+L++  ++DDE +     LPA+Q G+ C V++ E K +
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  480  RTAAPKSLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLIDRGYLLK  539
            +T +P +  +G LI AM N A +V D+ LK+ L++ +GIGTEATRAGII  L+ RG+L++
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  540  KKRALMASATAHTLIEAVPAAVADPGMTAIWEQALDEIEAGRLSLDAFVAKQAHWITQLI  599
             K++L +++ ++ L++ +P+++++PG+TA+WEQ LDE+ AGR+SLD F+AKQ++W++QL+
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  600  ANCGALTLSVPVEAGPVCPICNASMLRRKGKSGPFWSCSHYPDCKGTV  647
            A+  +  L++   ++P CP+C +  L+R+GKSG FW+C  YP+CKG V
Sbjct  600  AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  589 bits (2223),  Expect = 2e-169, Method: Compositional matrix adjust.
 Identities = 334/667 (51%), Positives = 491/667 (74%), Gaps = 6/667 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+++ +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+ALA L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDAS  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  +++  G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpvaqqaaqqiraagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRA  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAE  419
              SR WND K+TAHHGIIPT + ++LS +S+ E+ VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKA  479
            ++ G Q + + G+ +   GW  +++    D++++T   +  LPA++ G  CQV  AE K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVETGTSKRGA  659
            + Q  S +L+++ P +P+CP CG+ T QR GK+G FW+C +YP+CKG   +    +K   
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNNGNKGPR  655

Query  660  SRPRKSG  666
            +R RK++
Sbjct  656  GRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2222),  Expect = 2e-169, Method: Compositional matrix adjust.
 Identities = 336/667 (51%), Positives = 492/667 (74%), Gaps = 6/667 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+++ +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+ALA L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDAS  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  +++  G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpvaqqaaqqiraagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRA  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAE  419
              SR WND K+TAHHGIIPT + ++LS +S+ E+ VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETIARSQVLPALREGLACQVAEAEVKA  479
            ++ G Q + + G+ +   GW  +++    D++++T   +  LPA++ G  CQV  AE K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVETGTSKRGA  659
            +AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP+CKG   +    +K   
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG---IVNNGNKGPR  655

Query  660  SRPRKSG  666
            +R RK++
Sbjct  656  GRRRKPS  662

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2221),  Expect = 3e-169, Method: Compositional matrix adjust.
 Identities = 329/656 (51%), Positives = 487/656 (75%), Gaps = 3/656 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG L+G+GVT+TW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++ +G  F+++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRClqqpvaqqaalqIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q     R +  + +++ + ER ++++PL F LSTLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K+TAHHGIIPT + ++LS LS+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKA  479
            F+ G Q++ + G+ +V  GW+ +++  +  ED++D +    LP++++G  CQV   E K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG--KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTP  655
            +AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP+CKG +   +  P
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGP  654

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2221),  Expect = 3e-169, Method: Compositional matrix adjust.
 Identities = 329/656 (51%), Positives = 487/656 (75%), Gaps = 3/656 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG L+G+GVT+TW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++ +G  F+++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRClqqpvaqqaalqIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q     R +  + +++ + ER ++++PL F LSTLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K+TAHHGIIPT + ++LS LS+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKA  479
            F+ G Q++ + G+ +V  GW+ +++  +  ED++D +    LP++++G  CQV   E K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG--KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTP  655
            +AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP+CKG +   +  P
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGP  654

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2221),  Expect = 3e-169, Method: Compositional matrix adjust.
 Identities = 334/655 (51%), Positives = 474/655 (73%), Gaps = 1/655 (0%)

Query  1    MRLFLCEKPSQGRDIATVLGATRRGDGCLIGTETTVTWCIGHLLETAPPEAYGIQY-KNW  59
            MRL LCEKPSQGRDIA  LGAT+RG+G L G   TVTW  GHLLETA PE YG QY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDHLPIIPAQWKVEVKHKTAAQFKVIKRLLSEASAVVIATDADREGEMIARELLELCNY  119
              D LP++P QWK+ VK  + AQF VI+RLL +   VVIATDADREGE+IARELL+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVERLWLSALNEVSILKALSSLKSGQETFPLYHSALARSRADWLIGMNLSRLFTLLGR  179
            +G V RLW+SAL++ SI  AL+ L ++  T +LY ++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RAGYDGVLSVGRVQTPTLRLVVDRDRAIASFVSVPYWDVEVHLSFMGQSFIASWLPPSSG  239
             AG + VLSVGRVQTPTL +VV RDR I +FVS PY +V   ++  G  F + W+P++  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  RDEACRCLQQALARHAGQTITDGKTATVLSLQTEHFREPPPLPFDLSTLQEVCSRKLGLG  299
             DE  RC+Q ++A +  Q   +  TA++++ Q E+ ++++PL+F LSTLQ+ CSR  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLNIAQALYETHKATTYPRSDCRYLPASMFDEVPTVFDALLKTDSALQPAFEKLDRS  359
             Q  L+IAQ LYETHK TTYPR+DC YLP SM +E+P V+ A++ TD+ALQP    LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  LRSRAWNDAKATAHHGIIPTTEPANLARMSEQERQVYEQIRNHYLAQFLPHHEFDRTQVE  419
            + SR WND K TAHHGIIPT + ++L+++S+ ER+VY+ +R HYLAQFLP+ E+D T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LECGKERLTAVGKQILVQSWKGLLYDNTEDDEPSQKFQVLPVLQQGTQCAVNDVELKSMR  479
            ++ G + + + G+ ++  +WK+L+   +EDDE +     LP +Q G  C V++ E K ++
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  480  TTAPKPLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLIDRGYLLKK  539
            T +P P  +G LI AM N A +V D+ LK+ L++ +GIGTEATRAGII  L+ RG+L++ 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  540  KRALMASAAAHTLIEAVPAAIADPGMTAIWEQALDEIEAGRLSLDAFVAKQASWIAQLVE  599
            K++L +++ ++ L++ +P+++++PG+TA+WEQ LDE+ AGR+SLD F+AKQ+ W++QLV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  600  HCRALTLALPVETGPACPICNASMLRRTGKSGAFWSCSHYPDCKGTVPISKDIRR  654
            + R+  L++    +P+CP+C +  L+R GKSG FW+C  YP+CKG V  ++   R
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPR  655

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2221),  Expect = 3e-169, Method: Compositional matrix adjust.
 Identities = 329/656 (51%), Positives = 487/656 (75%), Gaps = 3/656 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG L+G+GVT+TW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++ +G  F+++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRClqqpvaqqaalqIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q     R +  + +++ + ER ++++PL F LSTLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K+TAHHGIIPT + ++LS LS+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKA  479
            F+ G Q++ + G+ +V  GW+ +++  +  ED++D +    LP++++G  CQV   E K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG--KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTP  655
            +AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP+CKG +   +  P
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGP  654

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  588 bits (2219),  Expect = 4e-169, Method: Compositional matrix adjust.
 Identities = 331/669 (50%), Positives = 494/669 (74%), Gaps = 6/669 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+++ +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+ALA L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFESVPYWAIDVSLSAGGQTFTAQWVAPDAS  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S PY  +  +++  G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpvaqqaaqqiraagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMEQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  VRSRAWNDTKVSAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K++AHHGIIPT + ++LS +S+ E+ VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LFCGQQKLVATGKQVVAKGWRLVLAEPQADEDGDGAARSQVLPALRDGMACQIAGADIKA  479
            +  G Q + + G+ +V  GW+ +++    D++++ +  +  LPA++ G  CQ+ GA+ K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIV  539
            L+T PP PY +G L+ AM   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEGGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + +G+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVATGTSRRGA  659
            +AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP+CKG +  +   +R   
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPR---  655

Query  660  SRPRRTSGG  668
            +R R+ S +
Sbjct  656  GRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  587 bits (2217),  Expect = 6e-169, Method: Compositional matrix adjust.
 Identities = 338/677 (50%), Positives = 487/677 (72%), Gaps = 17/677 (2%)

Query  1    MRVVLCEKPSQGKDIARVLGAHRREAGCLGGPGITVTWGSGHLIEAAPPEAYGEHFQR-W  59
            MR+VLCEKPSQG+DIA+ LGA +R  G L GPG+TVTW+ GHL+E+A PE YGE++ + W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   ---TLPIVPPRWQWVVKARSAAQFKVVKRLLGEASELIIATDADREGEMIAREMIDYCGY  116
                LP++P +W+ VVKA + AQF V++RLL +  E++IATDADREGE+IARE++DYC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  117  RGPVQRLWLSALNDASIRKAFGALRASSETLSLYHCALARSRADWLVGINLTRLFTLLGR  176
            +G V RLW+SAL+DASIR A++ L++SS T SLY  +++RSRADWL+G+NLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  177  HAGHDGVLSVGRVQTPTLKLVVDRDREIAAFVPVPFWSIDVSLSAANVPFSAHWLAPRTA  236
            +AG + VLSVGRVQTPTL +VV RDREI  FV+ P+  +  +++   V F++ W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  237  TDDAGRCLRQSVarhaadairaagtaQVVHTETERVREGPPLPFDLSTLQEVCSRRLGLE  296
             D+  RC++ +VA +  +  R + TA +++ + ER ++++PL+F LSTLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  297  VQETLDIAQALYETHKATTYPRTDAGYLPENMLAEVPTVIQSLVKTDPALQPLIDRLDFR  356
             Q  LDIAQ LYETHK TTYPRTD GYLP +M  E+P V+ ++V TDPALQP++  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  357  QRSRAWNDAKITAHHAIIPTLEPADISAMSAKELAVYRLIRAHYLAQFLPHHEFDRTVVR  416
              SR WND KITAHH+IIPT + +D+S +S  E  VY+L+R HYLAQFLP+ E+D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  417  FRCGGETLQAVGKRIAVPGWQHAFSAPSLPHVAADGADTEGSDEAPREQMLPVLQEGISC  476
            F  GG+ +++ G+ +  PGW+  F           G  +E+ ++   E  LP +Q G  C
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLF-----------GKMSEDDEDNTGETTLPAMQAGQVC  469

Query  477  QVSALDLKSLSTKPPRPYTQGELVKAMKTVARLVTDPRLKQKLKDTTGIGTEATRANIIS  536
            QV + + K L TKPP PY +G L+ AM   A +VTD+ LK+ LK+ +GIGTEATRA II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  537  GLLSRGFLIRKGRAVRASDTAMMLIDAVPAAIADPGTTAIWEQALDMIEARQMGLESFVE  596
             LL RGFL+R  ++++++  +  L+D +P+++++PG TA+WEQ LD + A +++L+ F+ 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  597  KQAAWVTQLVRQHLGTTLAIRSPEGPPCPLCGAATRQRTGRSGPFWSCSRYPDCKGTAPV  656
            KQ+ WV+QLV Q  +  L++++P +PPCP+CG+ T QR G+SG FW+C +YP+CKG   V
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--V  647

Query  657  APAQAGPDGQKRSRSRG  673
              ++ GP G++R  S +
Sbjct  648  NNGNKGPRGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  587 bits (2216),  Expect = 8e-169, Method: Compositional matrix adjust.
 Identities = 335/672 (50%), Positives = 492/672 (74%), Gaps = 9/672 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+ALA L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDAS  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  +++  G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  ADDAGRCLqqpiaqqaaqqiraagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  +A Q  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRT  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVAD  419
              SR WND K+TAHHGIIPT + ++LS +S+ E+ VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQKLVATGKQVVVKGWRLVLAEPEREGSADEDGDAPRSQVLPALRDGMACQVAGAD  479
            ++ G Q + + G+ +V  GW+ +++       +++D D      LPA++ G  CQV GA+
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK-----MSEDDEDNTGETTLPAMQAGQVCQVQGAE  475

Query  480  IKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARG  539
             K L+T PP PY +G L+ AM   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  YIVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWI  599
            ++V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  SQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPACKGTLPVATGTSR  659
            SQL+AQ  S +L+++ P +P+CP CG+ T QR GKSG FW+C +YP CKG +  +   +R
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPR  655

Query  660  RGASRPRRTSGG  671
               +R R+ S +
Sbjct  656  ---GRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  585 bits (2208),  Expect = 3e-168, Method: Compositional matrix adjust.
 Identities = 351/655 (54%), Positives = 471/655 (72%), Gaps = 11/655 (1%)

Query  3    RLFLCEKPTQARDIAKVLGASEKGNGCLKGRGITVTWGFGHLLEQANPEAYDPAL-KRWS  61
            RL LCEKP+Q+RDIAK LGA+++G+G L+G G+TVTW+ GHLLE A+PE Y+    K W 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWR  61

Query  62   MESLPILPTQWKLEVKPSAKKQFTVVKKLLSSASEVVIATDADREGEMIAREILEACQFS  121
             + LP+LP QWKL VK+ AK QF+V+++LL    EVVIATDADREGE+IARE+L+ C+F 
Sbjct  62   TDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQ  121

Query  122  GGVSRLWLPALDEASIRKALGDIRPGESTRLLYHAALGRSRADWLVGMNLTRAFTMRAKQ  181
            G V RLW++ALD+ASIR AL+D++P+  T  LY A++GRSRADWL+GMNLTR FT+ +++
Sbjct  122  GRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGRE  181

Query  182  LGYDLLLSVGRVQTPVLKLVVDRDREIANFVPKPFWEVVAVFQAEGGTFQAKWQPADDDV  241
             G + +LSVGRVQTP L +VV RDREI NFV+KP+ EV+A    +G  F +KW PA +  
Sbjct  182  AGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYC  241

Query  242  LDESGRCINQSAAQAVVARCQGLP-GQVTTLETTRKREAPPLAMDLGTLQQTCSKRWGYG  300
             DE  RCI+ + A  VV  C+  P + +   +  RK++++PLA  L+TLQQ+CS++WG  
Sbjct  242  -DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  301  AQQVLDIAQALYETHKATTYPRTDCRYLPLSQLDDAQQVVTALLTSDGELAPVVQSLDLT  360
            AQ VLDIAQ LYETHK TTYPRTDC YLPLS  ++  QV++A++ +D  L PVV SLD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  361  RKSRVWNDSKITAHHGIIPTTSPCDTSKMSEAEWNVYDLVRRHYLAQFLPPHEYDHTDVA  420
              SR+WND KITAHHGIIPT    D SK+S+AE+NVY+LVR HYLAQFLP  E D T+ +
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  421  LEVAGERFATTGRQVQVEGWKVLFRNVQQDDAAGDEATAKTSSQALPPLQAHANVPQSSL  480
            ++++G+ F T G  +   GWK LF ++ +DD        +T+  +LP++QA       + 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDE------DNTGETTLPAMQAGQVCQVQGA  474

Query  481  DLVSKTTTPPKPFAEGTLIGAMKNAARFEPNPKLKARLKESAGIGTEATRAGIIETLLKR  540
            +     T PP P+ +GTLI+AM NAA F  ++ LK  LKE+AGIGTEATRAGII+TLLKR
Sbjct  475  EQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKR  534

Query  541  KFLTKKGRAIVATATGRQLIDALPEVVTNPGMTALWEQALDSVAAGELSLEDFMAKQQTL  600
             FL +  +++ +T+ GR+L+D LP  +TNPG+TALWEQ LD VAAG +SL+DFMAKQ   
Sbjct  535  GFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQW  594

Query  601  VERLIEQAKSATINLPQEPAKSKACPECGAPMKKRKNDYGSFWGCTKYPDCKGMV  655
            V +L+ Q++S  + +   P  S +CP CG+   +R+   G FWGC KYP+CKG+V
Sbjct  595  VSQLVAQGRSQPLTMQAPP--SPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  585 bits (2208),  Expect = 3e-168, Method: Compositional matrix adjust.
 Identities = 332/661 (51%), Positives = 481/661 (73%), Gaps = 6/661 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGASVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G++V VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPIVPERWRVEPKAATVAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP++P++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSAETMPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYNGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWATEVALSHAGQTFVASWTPPQGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS P+     +++  G  F + W P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDEAGRCLRQPVAQQAAERLRAAGTAQVLSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             DE  RC++  VA Q  +  R + TA +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGHLPESMLAEVPAVLDSLVKTDPSLRPLIDRLDRQ  359
             Q  LDIAQ LYETHK TTYPR+D G LP SM  E+P VL ++V TDP+L+P++  LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMTEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K+TAHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LTCGGQSLVAVGKQIATAGWRQVLAAPALDDTDGEDARRGQVLPALKAGDACQVSQVELK  479
            +  GGQ + + G+ +  +GW+ +++  +    D+ED      LPA++AG+ CQV   E K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMS---EDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELVKAMKGVAKLVTDPRLKQKLKDTTGIGTEATRANIISGLLARGYL  539
             L+T PP PY +G L+ AM   A +VTD+ LK+ LK+ +GIGTEATRA II  LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  LKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEHALDMIEAGQMALDTFIAKQSSWVAR  599
            ++  ++++++  +  L+D +P+++++PG TA+WE+ LD + AG+++LD F+AKQS WV++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLDLKLPPAPDCPQCGAPMRQRSSKSGVFWSCSRYPDCKGTQPVEDAAAGKR  659
            LV Q R+  L ++ PP+P CP CG+   QR++KSG+FW+C +YP+CKG   V+++  G R
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNKGPR  655

Query  660  G  660
            G
Sbjct  656  G  656

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  583 bits (2202),  Expect = 1e-167, Method: Compositional matrix adjust.
 Identities = 337/654 (52%), Positives = 480/654 (74%), Gaps = 4/654 (0%)

Query  1    MRLYLCEKPSQGKDIAAVLGAKTRGDGCIKGNGVAVTWGIGHLLETAPPDAYGEHL-KNW  59
            MRL LCEKPSQG+DIA  LGA  RG+G ++G GV+VTW+ GHLLETA P+ YGE+  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDTLPILPAEWKVLVKPKTASQFKIVKQLLKQATELVIATDADREGEMIARELIEYCGY  119
              D LP+LP +WK++VK+ + +QF ++++LLKQ  E+VIATDADREGE+IAREL++YC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNEASIRQALNTVKQGSETYPLYLSALARSRADWLIGMNFSRLFTLLGR  179
            +G + RLW+SAL++ASIR AL  +  +S T +LY ++++RSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLRLVVDRDRDISNFIPKPFWSVEVQLWTAGQSFLAKWVADEYL  239
            +AG   VLSVGRVQTPTL +VV RDR+I NF++KP+  V   +   G  F +KWV+    
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  VDEEGRCLDqaaaaaalaalkssqaasTVSVDTKRGKDPAPLPFDLSTLQEVCSAKFGMG  299
             DEE RC++ + AA  +   + + +A+ ++ +  R K++APL+F LSTLQ+ CS   GM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDVAQSLYETHKATTYPRTDCGYLPESMFDEVPMVLDALNRTDPSIGKTLQLIDPE  359
             Q  LD+AQ LYETHK TTYPRTDCGYLP SM +E+P VL A+  TDP++   +  +D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDKKITGPHHGIIPTLEPANLSAMSEKERKVYELIRAHFLAQFLPTHEYDRTVA  419
              SR WNDKKIT+ HHGIIPT + ++LS +S+ ER+VY+L+R H+LAQFLP  E D T A
Sbjct  361  FVSRIWNDKKITA-HHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  420  TFECNAVLLQAVGKRIVIPGWKVLFSASSEEEANDSGGRSQILPVLQIGTRCDVQDLHLK  479
            TF+  + L+++ G+ +V PGWK LF+  SE++ +++G  +  LP +Q G  C+VQ+ + K
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQK  477

Query  480  SLKTEPPKAYTEGTLIKAMKTIAKLVKDPRLAQKLKETTGIGTEATRAGTIQGLIDRGSL  539
             L+T PP +Y +GTLI AM   A +V D+ L + LKE +GIGTEATRAG I+ L+ RG L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  IKKGSALRATEAAFSLIDAVPPAVADPGTTAIWEQALTMIEQGTLTLDDFIARQSSWITR  599
            ++   +L++T  + +L+D +P ++++PG TA+WEQ L  +  G ++LDDF+A+QS W+++
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVEQYKGTTLSIKVPEGPKCPLCSAKTSQRKGSSGVFWACSRYPECKGTVNIGT  653
            LV Q ++  L+++ P +P CP+C++KT QR+G SG+FW+C +YPECKG VN G 
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGN  651

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  583 bits (2200),  Expect = 1e-167, Method: Compositional matrix adjust.
 Identities = 326/652 (50%), Positives = 488/652 (75%), Gaps = 6/652 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAATPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++Y ++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLSAGVQAFTAHWVPPNAC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  ++ +++     F + WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpvaqqamqqIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRL  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+  VL +++ TDP+L+++++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAK  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGGQNLAATGKQVVTPGWRQVLAEPQSEdgdgdgdTAARAQVLPALHEGLACQVADID  479
            ++ GGQ + + G+ +V PGW+ +++    +D D  G+T+     LPA++ G  CQV + +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT-----LPAMQAGQVCQVQGAE  475

Query  480  LKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARG  539
             K L+T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+ RG
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  YLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWI  599
            +LV+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  SQLIAQYGNASLSIKAPQGPTCPQCGAPTRQRSSKSGPFWSCSRYPDCKGTL  651
            SQL+AQ  + +L+++AP +P CP CG+ T QR++KSG FW+C +YP+CKG +
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  582 bits (2197),  Expect = 2e-167, Method: Compositional matrix adjust.
 Identities = 328/650 (51%), Positives = 483/650 (75%), Gaps = 4/650 (0%)

Query  1    MRLFLCEKPSQGKDIGKVLGATQRDNGCLKGPGVIVTWCIGHLVEAAPPEAYDANL-KHW  59
            MRL LCEKPSQG+DI+K LGATQR++G L+GPGV VTW  GHL+E+A PE Y+ +  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPERWRIEVKPKTAAQFKVVKQLLAQATELVIATDADREGEMIAREIVELCGY  119
              + LP++P++W++ VK+ + AQF V+++LL Q  E+VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALAALKPSSETLPMYHSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR ALA L PSS T ++Y ++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREINQFVSIPFWAIDVALSATGQSFIAQWLAPEAC  239
            +AG + VLSVGRVQTPTL +VV RDREI++FVS P+  +  +++  G  F ++W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDEAGRCLQESVAQQAAQQLRANGTAQVASVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             DE  RC+Q +VA Q  Q  R   TA + + + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMQADVPAVLDSLLRTDPALRPVMEQLDRR  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM+ ++P VL +++ TDPAL+PV+  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAR  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCAGQHLQAVGKQIVIPGWRLVLVeqqaedaddeaaPRSQVLPALNQGLSCQMNTVDLK  479
            ++ +GQ +++ G+ +V PGW+ ++     +D D+ +      LPA++ G  CQ++  + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET---TLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDTVGIGTEATRANIINGLLTRGYL  539
             L+T PP PY +G L+ AM + A +V+D+ LK+ LK+  GIGTEATRA II+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  IKKGRAIRASEAAGTLIDTVPAAIADPGTTAVWEQALDMIEAGELTHDVFTGKQSAWISQ  599
            ++  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG ++ D F +KQS W+SQ
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  IIAQYQGTAMTIKVPQGPACPQCGSATRQRTGKNGPFWSCSRYPECKGTV  649
            ++AQ ++ ++T++ P +P+CP CG+ T QR GK+G FW+C +YPECKG V
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  582 bits (2197),  Expect = 2e-167, Method: Compositional matrix adjust.
 Identities = 327/665 (50%), Positives = 495/665 (75%), Gaps = 8/665 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSGQAFTAQWISPDTC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +   ++ +G  F ++W+++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDSGRCLqqpvaqqaaqqIRATGSAQVVSVETERVREGPPLPFDLGTLQELCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R T +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLKTDFSLRPIIDQLDRT  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TD +L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K++AHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSCQVADVDLKA  479
            ++ G Q + + G+ +V  GW+ +++    +++ +T+  +  LPA++ G  CQV + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIISGLIARGYLM  539
            L+T+P+ PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II  L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  ITQYASASLSIKVPHGPACPQCGAPTHQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRVA  659
            ++Q  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   V++G     +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNK---G  653

Query  660  SRSRR  664
            +R+RR
Sbjct  654  PRGRR  658

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  581 bits (2195),  Expect = 4e-167, Method: Compositional matrix adjust.
 Identities = 328/665 (50%), Positives = 495/665 (75%), Gaps = 8/665 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSGQAFTAQWVSPDTC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +   ++ +G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDSGRCLqqpvaqqaaqqIRATGSAQVVSVETERVREGPPLPFDLGTLQELCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R T +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLKTDFSLRPIIDQLDRT  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TD +L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K++AHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSCQVADVDLKA  479
            ++ G Q + + G+ +V  GW+ +++    +++ +T+  +  LPA++ G  CQV + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIISGLIARGYLM  539
            L+T+P+ PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II  L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  ITQYASASLSIKVPHGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRVA  659
            ++Q  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   V++G     +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNK---G  653

Query  660  SRSRR  664
            +R+RR
Sbjct  654  PRGRR  658

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  581 bits (2193),  Expect = 5e-167, Method: Compositional matrix adjust.
 Identities = 330/650 (51%), Positives = 486/650 (75%), Gaps = 4/650 (0%)

Query  1    MRLFLCEKPSQGKDIGRLLGARQRGNGCLNGPGVVVTWCIGHLVEAAPPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGA QRG+G LNGPGV VTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   TIEQLPIIPQHWRVEVKPKTAAQFKVVKDLLSKATELVIATDADREGELIAREIIDLCGY  119
              + LP++PQ+W++ VK+ + AQF V++ LL +  E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIHAALGKLKPSGDTLPMYHSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASI++AL+ L PS+ T ++Y ++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RAGYDGVLSVGRVQTPTLRLVVDRDREIAAFVSVPFWSIEVALSCTGQTFTAQWLPPSAS  239
             AG + VLSVGRVQTPTL +VV RDREI  FVS P+  +  +++  G  F ++W+P++  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQEPvaqqavqriraagaaqMVSVETERMREGAPLPFDLGTLQEVCSKQFGLD  299
             D+  RC+Q  VA Q VQ  R + +A +++ + ER +++APL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQSLYETHKATTYPRSDSGYLPESMHAEAPTVLDSLLKTDPSLRPIIDQLDRT  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM+ E P VL +++ TDP+L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QHSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAAYRLIRAHYLAQFLPPHEFDRTTAR  419
              SR WND K++AHHGIIPT + ++LS +S+ E   Y+L+R HYLAQFLP  E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGDQTLQAVGKHVVVPGWRLVLaepqpddagddaapRSQVLPALHQGLACQVAGVDLK  479
            F+ G+Q +++ G+ +V PGW+ +++    DD ++ +      LPA++ G  CQV G + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTG---ETTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDSVGIGTEATRANIIGGLLNRGYL  539
             L+T PP PY +G L+ AM + A +V+D+ LK+ LK++ GIGTEATRA II+ LL+RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  IKKGRAIRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIETGQLALDTFIDKQAAWVTQ  599
            ++  ++++++  +  L+D +P+++++PG TA+WEQ LD + +G+++LD F+ KQ+ WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LIAQYRGTSLSIKIPEGPACPQCGGATRQRSGKSGPFWSCAKYPDCKGTL  649
            L+AQ R+ +L+++ P +P+CP CGG T QR+GKSG FW+C KYP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  581 bits (2193),  Expect = 5e-167, Method: Compositional matrix adjust.
 Identities = 324/662 (49%), Positives = 489/662 (74%), Gaps = 4/662 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAY  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  +++ +G  F ++WVP+  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDTGRCLQQPVaqraaqqirgagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA +  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E++ VL +++ TDP+L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKA  479
            +  G Q + + G+ +V  GW  ++     D++++++  +  LPA++ G  C V + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIV  539
            L+T PP PY +G L+ +M   A +VTD+ LK+ +++  GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGA  659
            +AQ    +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG +  ++  + RG 
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGR  657

Query  660  SR  661
             R
Sbjct  658  RR  659

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  581 bits (2193),  Expect = 5e-167, Method: Compositional matrix adjust.
 Identities = 324/662 (49%), Positives = 489/662 (74%), Gaps = 4/662 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAY  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +  +++ +G  F ++WVP+  Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDTGRCLQQPVaqraaqqirgagsaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA +  Q  R + +A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E++ VL +++ TDP+L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKA  479
            +  G Q + + G+ +V  GW  ++     D++++++  +  LPA++ G  C V + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIV  539
            L+T PP PY +G L+ +M   A +VTD+ LK+ +++  GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGA  659
            +AQ    +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG +  ++  + RG 
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGR  657

Query  660  SR  661
             R
Sbjct  658  RR  659

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  580 bits (2192),  Expect = 6e-167, Method: Compositional matrix adjust.
 Identities = 328/665 (50%), Positives = 494/665 (75%), Gaps = 8/665 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSGQAFTAQWVSPDTC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +   ++ +G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDSGRCLqqpvaqqaaqqIRATGSAQVVSVETERVREGPPLPFDLGTLQELCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R T +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLPKTDFSLRPIIDQLDRT  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL ++  TD +L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K++AHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSCQVADVDLKA  479
            ++ G Q + + G+ +V  GW+ +++    +++ +T+  +  LPA++ G  CQV + + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIISGLIARGYLM  539
            L+T+P+ PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II  L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  ITQYASASLSIKVPHGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRVA  659
            ++Q  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   V++G     +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNK---G  653

Query  660  SRSRR  664
            +R+RR
Sbjct  654  PRGRR  658

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  580 bits (2191),  Expect = 7e-167, Method: Compositional matrix adjust.
 Identities = 328/665 (50%), Positives = 496/665 (75%), Gaps = 8/665 (1%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVTVTW  GHL+E+A PE Y+EQ  K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIEQLPIIPQRWQVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIDLCGY  119
              + LP++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PS+ T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYLTTSGQAFTAQWVSPDTC  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS PY  +   ++ +G  F ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDSGRCLqqpvaqqaaqqLRATGSAQVVSVETERVREGPPLPFDLGTLQELCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R T +A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLKTDFSLRPIIDQLDRT  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TD +L+P++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAVYKLIRAHYLAQFLPHHEFDRTVAN  419
              SR WND K++AHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQVLPALREGVSCQVADADLKA  479
            ++ G Q + + G+ +V  GW+ +++    +++ +T+  +  LPA++ G  CQV +A+ K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTQPSRPYTQGELVKSMKGVAKLISDPRLKQKLKDTVGIGTEATRANIISGLIARGYLM  539
            L+T+P+ PY +G L+ +M   A +++D+ LK+ LK+  GIGTEATRA II  L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  ITQYASASLSIKVPHGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRVA  659
            ++Q  S +L+++ P +P+CP CG+ T QR+GKSG FW+C +YP+CKG   V++G     +
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNGNK---G  653

Query  660  SRSRR  664
            +R+RR
Sbjct  654  PRGRR  658

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  579 bits (2185),  Expect = 2e-166, Method: Compositional matrix adjust.
 Identities = 331/667 (50%), Positives = 489/667 (74%), Gaps = 4/667 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVIVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG L+G+GV VTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSAQARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++ +RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++  G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  IDDAGRCLqqpvaqqaaqqiraagsaqVVSVETKRVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  Q  R + +A +++ +  R ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSVMSEKELAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQKLAATGKQVVAQGWRLVLAEPQADEDGDDAARSQVLPALREGMACQVAEAEIKA  479
            ++ G Q + + G+ +V  GW+ +++  +  ED++D +    LPA++ G  CQV  AE K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG--KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPPKPYTQGELVKSMKGVAKLVTDPRLKQKLKETVGIGTEATRANIISGLIARGYLV  539
            L+T PP PY +G L+ +M   A +VTD+ LK+ LKE  GIGTEATRA II  L+ RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPTAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P ++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGSTSLSIKVPQGPACPQCGATTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGA  659
            +AQ  S +L+++ P +P+CP CG+ T QR GK+G FW+C +YP+CKG +  ++  + RG 
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGR  657

Query  660  SRPRTSG  666
             R  +++
Sbjct  658  RRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  578 bits (2183),  Expect = 3e-166, Method: Compositional matrix adjust.
 Identities = 331/667 (50%), Positives = 491/667 (74%), Gaps = 4/667 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTVTWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG L+G+GVTVTW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIVPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++  G  F+++WVP+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpiaqqaaqqiraassaqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  +A Q  Q  R +++A +++ + ER ++++PL F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYWLIRAHYLAQFLPHHEFDRTIAE  419
              SR WND K+TAHHGIIPT + ++LS +S+ E  VY L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKA  479
            ++ G Q + + G+ +   GW  +++    D++++T   +  LPA++ G  CQV  AE K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLV  539
            L+T PP PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGA  659
            + Q  S +L+++ P +P+CP CG+ T QR GK+G FW+C +YP+CKG +  ++  + RG 
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGR  657

Query  660  SRPRSSG  666
             R  S++
Sbjct  658  RRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  577 bits (2180),  Expect = 5e-166, Method: Compositional matrix adjust.
 Identities = 330/656 (51%), Positives = 486/656 (75%), Gaps = 3/656 (0%)

Query  1    MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTITWCIGHLVEAAAPEVYDAAL-KRW  59
            MRL LCEKPSQG+DI+++LGATQRGEG LNG+GVT+TW  GHL+E+A PEVY+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGY  119
              + LP++PQQW++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR+AL+ L+PSS T ++YY++++RSRADWL+GMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAEGQAFAAQWVAPDDC  239
            +AG + VLSVGRVQTPTL +VV RDREI  F S P+  +  +++ +G  F+++WV++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLqqpvaqqaaqqiraagsaqVVSVGTERVREGPPLLFDLSTLQEVCSRQVGLD  299
             D+  RC+Q  VA Q  Q  R + +A +++   ER ++++PL F LSTLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLNTDPSLRPIMGQLDRS  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM  E+P VL +++ TDP+L+P+++ LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSALSEKELAVYRLIRAHYLAQFLPHHEFDRTVAE  419
              SR WND K+TAHHGIIPT + ++LS LS+ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGQQTLVATGKQVVVKGWRLVLAEPQADEDGDDTARSQVLPPLREGLACQVAEVEIKA  479
            F+ G Q + + G+ +V  GW+ +++  +  ED++D +    LP+++ G  CQV   E K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFG--KMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LKTMPAKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIV  539
            L+T P+ PY +G L+ +M   A FVTD+ LK+ LK+ +GIGTEATRA II  L+ RG++V
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQL  599
            +  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IAQYGCVSLSIKLSHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTP  655
            +AQ    +L+++ + +P+CP CG+ T QR GKSG FW+C +YP+CKG +   +  P
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGP  654

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  577 bits (2178),  Expect = 8e-166, Method: Compositional matrix adjust.
 Identities = 327/650 (51%), Positives = 476/650 (74%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYSGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQPFVASWTPPQGS  239
            +AG + VLSVGRVQTPTL +VV RDREI  FV  P+  +  +++  G  F + W P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQQPvaqqaadriraardaqvvSVDTERVREAPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  +  R +  A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATDPSLRPLIGQLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL A+++TDP+L+P+++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K++AHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDALRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALRTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLPPTPACPQCGAPMQQRTGKSGAFWSCSRYPDCRGTL  649
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+C+G +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  569 bits (2149),  Expect = 2e-163, Method: Compositional matrix adjust.
 Identities = 336/677 (50%), Positives = 484/677 (72%), Gaps = 14/677 (2%)

Query  1    MRVVLCEKPSQGKDIARVLGARQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQR-W  59
            MR+VLCEKPSQG+DIA+ LGA QR  G L GPG+ VTW+ GHL+E+A PE YGE++ + W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCGY  119
              + LP++PQQW+ VVKAD+ +QF V++RLL Q  E++IATDADREGE+IAREL++YC +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L++S  T +LY  +++RS+ADWL+G+NLTRLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  KAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLSAGAQAFSAHWVPPATV  239
             AG++ VLSVGRVQTPTL +V  RDREI  FV+ P+  +  +++  +  F++ WVP+A  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLqqsaaqhaaaavrtaghaqVTGIDTERVQEGPPLPFDLSTLQEVCSRRLGLD  299
             D   RC+Q + A +     R +  A +   + ER ++++PL+F LSTLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPALQPLMQRLDLG  359
             Q  LDIAQ LYETHK TTYPRTD GYLP +M  E+P V+ +++ TDPALQP++  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLPHYAYDRTMVR  419
              SR WN  KI+AHH+IIPT + +DLSK+S+ E  VY+L+R HYLAQFLP+   D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQALPTLHEGMAC  479
            +  GGQ +++ G+ +V +GWK+ F+  S           E D +   + +LP+++ G  C
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMS-----------EDDEDNTGETTLPAMQAGQVC  469

Query  480  EVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIGTEATRANIIS  539
            +V++ + K L TK+P+PY +G L+ AM   A +VTD+ LK+ L++ +GIGTEATRA II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  540  GLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEARTMDLDTFVS  599
             LL RGFLVR  + ++++  +  L+D +P+++++PG TA+WEQ L+ + A  + LD F++
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  600  KQAAWVSQLVEQHREATLAIRVpagppcplcgaaTRKRTGKTGAFWSCSRYPDCKGTVAI  659
            KQ+ WVSQLV Q R   L+++ P++PPCP+CG+ T +R GK+G FW+C +YP+CKG V  
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV--  647

Query  660  DSAEAGRRNGPRKPRAA  676
            ++++ G R   RKP +A
Sbjct  648  NNGNKGPRGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  567 bits (2142),  Expect = 5e-163, Method: Compositional matrix adjust.
 Identities = 334/668 (50%), Positives = 483/668 (73%), Gaps = 5/668 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGHRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGDQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA +RG+G  +G+GV VTW  GHL+E+  PE YG+QY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  HGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYMGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAVDVLLSHAGRSFTASWIPPEGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS PY  V   ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPVAQQAADCIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLD  299
             D   RC+Q  VA Q  +  R +  A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATDPSLRPLIGQLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL A+++TDP+L+P+++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K+TAHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANTINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA  I+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLppapacpqcgapmqqRTGKSGAFWSCSRYPDCKGTLPIESPTGRRS  659
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+CKG +  ++  G R+
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRG  656

Query  660  APRKRCAA  667
              RK  +A
Sbjct  657  RRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  564 bits (2128),  Expect = 7e-162, Method: Compositional matrix adjust.
 Identities = 328/650 (51%), Positives = 475/650 (74%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSDETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS  T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQSFVASWTPPQGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FV  P+  +  +++  G  F + W P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  ADDADRCLQQPVAQQAAEFLRAAGTAQVLSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q  ++ R + TA +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLNSLVKTDPSLRPLIERLDRQ  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL+++V TDP+L+P++  LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K++AHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKLVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A +VTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMTLDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLppapacpqcaapmqqRTGKSGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ PP+P+CP C++   QR GKSG FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  563 bits (2127),  Expect = 8e-162, Method: Compositional matrix adjust.
 Identities = 326/650 (51%), Positives = 473/650 (73%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKSATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCSY  119
              + LP+LP++W++  K+ + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDVSIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+D SIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQSFVASWTPPQGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FV  P+  +  +++  G  F + W P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQQPVAQQAVERLRTAGAAQVRSVETERVREGPPLPFDLGTLQEVCSKQLGLD  299
             D+  RC+Q  VA Q V+  R + +A + + + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSMVKTDPSLRPLIERLDRQ  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL ++V TDP+L+P++  LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K++AHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEHALDMIEAGQMALDTFIEKQAAWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WE+ LD + AG+++LD F+ KQ+ WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLppapacpqcgapmqqRTGKSGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  559 bits (2111),  Expect = 1e-160, Method: Compositional matrix adjust.
 Identities = 331/670 (50%), Positives = 481/670 (72%), Gaps = 7/670 (1%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRRNGCYSGAGIVVTWCIGHLVEAVPPEGYDER-DKRW  59
            MR+ LCEKPSQG+DIA+ LGA QR +G  +G+G+ VTW  GHL+E+  PE Y+E+ +K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VIEQLPIIPERWRVEPKAATAAQFKIVKQLVGQATELVIATDADREGEMIAREIIELCGY  119
              + LP++P++W++  KA + AQF ++++L+ Q  E+VIATDADREGE+IARE+++ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGAIQRLWLSALNDASIRKALGALKSSAETLPLYYSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L +S+ T +LYY++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSAPFWAVEVALSHAGQPFTASWTPPEGC  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS P+  V  +++  G  F + W P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDEAGRCLQQPVAQQAAERMRATGSAQVASVETERVREGPPLPFDLGTLQELCSQQLGLD  299
             DE  RC+Q  VA Q  +  R T +A + + + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIDRLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL ++V TDP+L+P++  LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWSDAKVTAHHGIIPTLEPANLSAMNDKELAVYKLIRAHYLAQFLPHHEFDRTVAE  419
              SR W+D K+TAHHGIIPT + ++LS ++D E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LACGGQSLLAVGKQIAVAGWRQVLASSEEGGADSDDAQRSQVLPALRAGLSCQVGHVDLK  479
            +  GGQ + + G+ +  +GW+ +++   E   D +D      LPA++AG  CQV   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSE---DDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLGRGYL  539
             L+T PP PY +G L+ AM   A +VTD+ LK+ LK+ +GIGTEATRA II  LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  LTKGRAVRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIEAGQMTLDAFIAKQSAWVTQ  599
            +   ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+AKQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGTTLAIKLppspspscpQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVDTSTGK  659
            LV Q R+  L+++  ++PSP+CP CG+   QR GKSG FW+C +YP+CKG +  + + G 
Sbjct  598  LVAQGRSQPLTMQ--APPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN-NGNKGP  654

Query  660  RSASRKQRAS  669
            R+  RK  ++
Sbjct  655  RGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  557 bits (2103),  Expect = 5e-160, Method: Compositional matrix adjust.
 Identities = 318/602 (53%), Positives = 455/602 (76%), Gaps = 6/602 (0%)

Query  1    MQLYLCEKPSQARDIARVLDARNRSDGYLHNATVTITWCFGHLLSMAAPEDYDPAL-KHW  59
            M+L LCEKPSQ+RDIA+ L+A +R++G+L+ + VT+TW  GHLL  A PE Y+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   RAEHLPFIPPAWRLVIRPEVRKQFRIIEKLLKQADAVVIATDADREGETIAREILEQCRW  119
            R++ LP++P  W+LV++++ + QF +I++LLKQ D VVIATDADREGE IARE+L+ C+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIHKALAAMRSGDSTYPLYQAGLARARADWLVGINMTRACTLMNR  179
            +G V RLW+SALDDASI+ ALA ++++  T +LY AG++R+RADWL+G+N+TR  TL+ R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RHK--GVLSVGRVQTPTLRLVVERDREISRFTPRPWWRVDARLHAEGTTFLAQWQPDGVY  237
                  VLSVGRVQTPTL +VV RDREI  F ++P   V A +  +G  F ++W P + Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  238  CDDEGRCIRESAAREATASLQQAGTTLVLDVTTRREKTPPPLAFTLSALQQVCSKQWGMG  297
            CD+E RCI+ + A +     +Q+ T+ +++    R K ++PLAF+LS+LQQ CS++WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  298  AQEVLDIAQRLYETHKATTYPRTDCGWLPLSMHTEAPQVLAALVASDISLQPLATQLNLQ  357
            AQ VLDIAQ+LYETHK TTYPRTDCG LPLSM+ E PQVL+A+V++D +LQP+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  358  QHSRLWDDSKITAHHGIIPTRKTVDLTQMNDSERKVYGLVRSHFLAQFLSDHEVDKTDLR  417
              SR+W+D KITAHHGIIPT+ T DL++++D+ER+VY LVR H+LAQFL++ E+D T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  418  LNCAGETLAARGSVVIVSGWQQLFLREMATHSPEET--QSLPVLQQGQTCQVEQVDVRAR  475
            +N +G+ + +RG+V++ +GW+ LF + M+ +  ++T   +LP +Q GQ CQV+  + +  
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK-MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  476  QTQPPEHYTEGTLIAAMKNAARFVSDERLKQRLKENAGIGTEATRAGIIQTLLKRGYLIK  535
            QT+PP  Y +GTLIAAM NAA FV+D  LK+ LKENAGIGTEATRAGII+TLLKRG+L++
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  536  QRRFLLATDTASALIDALPEKLKDPGTTALWEQMLDDIATGKMGLEAFLVQQQETVTALT  595
            +++ L +T  +  L+D LP  L +PG TALWEQMLD++A+G+++L+ F+ +Q + V+ L 
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  596  AQ  597
            AQ
Sbjct  600  AQ  601

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  556 bits (2098),  Expect = 1e-159, Method: Compositional matrix adjust.
 Identities = 329/669 (50%), Positives = 478/669 (72%), Gaps = 7/669 (1%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRSNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QR++G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPIVPERWRVEPKVATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP++P++W++  K  + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAADVLLSHAGQSFTASWIPPEGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS PY      ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPVAQQAVDRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSRQLGLD  299
             D   RC+Q  VA Q V+  R +  A +++ + ER ++++PL+F L+TLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATEPSLRPLLGQLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL A+++T+P+L+P+++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVTAHHGIIPTLEPAKLLAMSEKELAVYQLIRGRYLAQFLPHHEFDRTVTQ  419
              SR WND K+TAHHGIIPT + + L  +S+ E  VYQL+R +YLAQFLP+ E+D T + 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LACGGQSLVAVGKQIAVIGWRQVLATPEPDAADGEEAQRSQVLPPLASGSRCGVEQVELK  479
            +  GGQ + + G+ +   GW+ +++     + D+E+      LP++ +G  C V+  E K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKM---SEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  ALRTLPPKPYTQGELVKVMKGVAKLVDDPRLKQKLKETTGIGTEATRASTIKGLLDRGYL  539
             L+T PP PY +G L+  M   A +V D+ LK+ LKE +GIGTEATRA+ I  LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  LKKGRAIRASDAAFTLIDAVPAAIADPGMTAIWEQALDMIEAGQMTLDTFIAKQSTWVAQ  599
            ++  ++++++  +  L+D +P+++++PG+TA+WEQ LD + AG+++LD F+AKQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQHRGATlsialppsppcpqcgapMRQRTGKSGAFWSCSRYPDCKGTLPVESSASKRG  659
            LV Q R+  L++  PPSPPCP CG+   QR GKSG FW+C +YP+CKG +   + +++  
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPR--  655

Query  660  APRKRRTVP  668
              R+R+  P
Sbjct  656  -GRRRKPSP  663

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  554 bits (2092),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 327/649 (51%), Positives = 464/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLASVLGATSKGDGLLATNDKSIIVTWGFGHLVEQYQPEDYDEVW-K  59
            M+L +CEKPSQ+RD+A  LGAT +G+G+L  N+ ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFL--NGPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMAPKKESKKQYNVVIGLIKKASLVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q+ V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLALVVNRDREIANFVPKAHYSLAVQLATASDETFVAGLSI  239
            ++  G  G+ LSVGRVQ+PTLA+VV+RDREI NFV+K+ + +   +A  ++  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQVGIAKVITVETKREKKAPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +Q   A +I  +  R K+++PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQLTEVPMVIRSLVAADSELQTLLPR  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   E+P V+ ++V++D+ LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLQQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLETDK  419
            L+ Q  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TIATLQSSGHTLIARGNVIVSQGWRILFGKNADEDVGSDDEKQGLPALTANQQCRVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK +++D ++ +E   LPA+ A Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLEAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FLIKKKKSLMASAEAIALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDDFMQRQETFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LDDFM +Q   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  RQLIGNCMQQGMSLGNIEIRKCPECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL+++   Q +++       CP CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  554 bits (2092),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 327/649 (51%), Positives = 464/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLASVLGATSKGDGLLATNDKSIIVTWGFGHLVEQYQPEDYDEVW-K  59
            M+L +CEKPSQ+RD+A  LGAT +G+G+L  N+ ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFL--NGPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMAPKKESKKQYNVVIGLIKKASLVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q+ V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLALVVNRDREIANFVPKAHYSLAVQLATASDETFVAGLSI  239
            ++  G  G+ LSVGRVQ+PTLA+VV+RDREI NFV+K+ + +   +A  ++  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQVGIAKVITVETKREKKAPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +Q   A +I  +  R K+++PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQLTEVPMVIRSLVAADSELQTLLPR  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   E+P V+ ++V++D+ LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLQQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLETDK  419
            L+ Q  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TIATLQSSGHTLIARGNVIVSQGWRILFGKNADEDVGSDDEKQGLPALTANQQCRVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK +++D ++ +E   LPA+ A Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLEAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FLIKKKKSLMASAEAIALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDDFMQRQETFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LDDFM +Q   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  RQLIGNCMQQGMSLGNIEIRKCPECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL+++   Q +++       CP CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  554 bits (2092),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 327/649 (51%), Positives = 464/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLASVLGATSKGDGLLATNDKSIIVTWGFGHLVEQYQPEDYDEVW-K  59
            M+L +CEKPSQ+RD+A  LGAT +G+G+L  N+ ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFL--NGPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMAPKKESKKQYNVVIGLIKKASLVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q+ V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLALVVNRDREIANFVPKAHYSLAVQLATASDETFVAGLSI  239
            ++  G  G+ LSVGRVQ+PTLA+VV+RDREI NFV+K+ + +   +A  ++  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQVGIAKVITVETKREKKAPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +Q   A +I  +  R K+++PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQLTEVPMVIRSLVAADSELQTLLPR  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   E+P V+ ++V++D+ LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLQQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLETDK  419
            L+ Q  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TIATLQSSGHTLIARGNVIVSQGWRILFGKNADEDVGSDDEKQGLPALTANQQCRVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK +++D ++ +E   LPA+ A Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLEAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FLIKKKKSLMASAEAIALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDDFMQRQETFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LDDFM +Q   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  RQLIGNCMQQGMSLGNIEIRKCPECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL+++   Q +++       CP CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  554 bits (2092),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 327/649 (51%), Positives = 464/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLASVLGATSKGDGLLATNDKSIIVTWGFGHLVEQYQPEDYDEVW-K  59
            M+L +CEKPSQ+RD+A  LGAT +G+G+L  N+ ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFL--NGPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMAPKKESKKQYNVVIGLIKKASLVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q+ V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLALVVNRDREIANFVPKAHYSLAVQLATASDETFVAGLSI  239
            ++  G  G+ LSVGRVQ+PTLA+VV+RDREI NFV+K+ + +   +A  ++  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQVGIAKVITVETKREKKAPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +Q   A +I  +  R K+++PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQLTEVPMVIRSLVAADSELQTLLPR  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   E+P V+ ++V++D+ LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLQQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLETDK  419
            L+ Q  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TIATLQSSGHTLIARGNVIVSQGWRILFGKNADEDVGSDDEKQGLPALTANQQCRVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK +++D ++ +E   LPA+ A Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLEAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FLIKKKKSLMASAEAIALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDDFMQRQETFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LDDFM +Q   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  RQLIGNCMQQGMSLGNIEIRKCPECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL+++   Q +++       CP CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  554 bits (2092),  Expect = 4e-159, Method: Compositional matrix adjust.
 Identities = 327/649 (51%), Positives = 464/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLASVLGATSKGDGLLATNDKSIIVTWGFGHLVEQYQPEDYDEVW-K  59
            M+L +CEKPSQ+RD+A  LGAT +G+G+L  N+ ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFL--NGPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMAPKKESKKQYNVVIGLIKKASLVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q+ V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLALVVNRDREIANFVPKAHYSLAVQLATASDETFVAGLSI  239
            ++  G  G+ LSVGRVQ+PTLA+VV+RDREI NFV+K+ + +   +A  ++  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQVGIAKVITVETKREKKAPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +Q   A +I  +  R K+++PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQLTEVPMVIRSLVAADSELQTLLPR  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   E+P V+ ++V++D+ LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLQQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLETDK  419
            L+ Q  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TIATLQSSGHTLIARGNVIVSQGWRILFGKNADEDVGSDDEKQGLPALTANQQCRVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK +++D ++ +E   LPA+ A Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLEAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FLIKKKKSLMASAEAIALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDDFMQRQETFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LDDFM +Q   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  RQLIGNCMQQGMSLGNIEIRKCPECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL+++   Q +++       CP CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  553 bits (2087),  Expect = 1e-158, Method: Compositional matrix adjust.
 Identities = 320/660 (49%), Positives = 482/660 (74%), Gaps = 8/660 (1%)

Query  1    MRLFICEKPSQARDIARVLQASWRGDGYLQGQNVTVTWCIGHLLETAPPESYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A+ RG+G+L+G  VTVTW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPDHWQLVVKPKVASQLKVIDQLLQRCAEVVIATDADREGEMIAREILERCQY  118
              D LP++P++W+LVVK+   +Q+ VI++LL++  EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  QGPVLRLWLSALDEASIRRALAALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGR  178
            QG V+RLW+SALD+ASIR ALA L+P+ +T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RAGFDGVLPVGRVQTPTLRLVVERDRAIASFVPHPFWNVDAQLVADGVSFKASWQPPASV  238
             AG++ VL+VGRVQTPTL +VV RDR I +FV+ P+ +V A +  +GV F + W P+A  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  CDDEGRCLDEaaarqaalrlsqHGTARIGTIEVEHVREGPPLPFDLGTLQEVCSAKLGLG  298
            CD+E RC++ + A Q      Q  TA I   ++E+ ++++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQETLGIAQALYETHKATTYPRTDCGYLPESMLDEVPRILHALVAPSPALGQVIKALDPC  358
            AQ  L+IAQ LYETHK TTYPRTDCGYLP SM +E+P++L A+V+  PAL  V+ +LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  359  RRSRAWNSSKITAHHGIIPTAIKLDLTQLSEREQAVYALIRARYLAQFLPEHEYLKTQVL  418
              SR WN  KITAHHGIIPT    DL++LS+ E+ VY L+R +YLAQFLP+ E   T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  419  LHSQADQLLARGKQILVRGWKAVINETHGNEPGEQTQ-RLPTLRESVSVALTDAAAIIQR  477
            ++  ++ + +RG+ ++  GWK+++     ++ ++  +  LP+++ +    + +A   + +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  478  THPPKAYTEGTLVKAMKTIANQVADLRLKQTLRESCGLGTEATRAAIIQGLIDHGYLTKK  537
            T PP +Y +GTL+ AM   A  V+D  LK+ L+E+ G+GTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  538  KRSLaasaaaHTLIEAVPAEVADPVLTALWEQALGRIESGQLSVETFLAKQSQWLTRLVR  597
            K++L +++ ++ L++ +P+ +++P LTALWEQ L+ + +G++S++ F+AKQSQW+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  598  S--NASLTLQPPPSKGPLCPVCCSGMRQRKGRTGSFWSCIRYPDCKG-TKPVTKAKRPKK  654
               + +LT+Q+PPS  P CPVC +   QR+G++G FW+C++YP+CKG  +   K+ R ++
Sbjct  601  QGRSQPLTMQAPPS--PPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRR  658

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  552 bits (2082),  Expect = 3e-158, Method: Compositional matrix adjust.
 Identities = 314/656 (48%), Positives = 482/656 (74%), Gaps = 3/656 (0%)

Query  1    MRLFLCEKPSQGKDIARVLGALRRGNGCYNGPGISVTWCIGHLVEAAPPEAYDERF-KRW  59
            MRL LCEKPSQG+DIA+ LGA +RG+G  NGPG++VTW  GHL+E+A PE Y+E++ K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDQLPIVPTNWRVDVKADTAAQYKVVKQLLAKTTELVIATDADREGEMIAREILELCHY  119
              D LP++P +W++ VKAD+ AQ+ V+++LL +  E+VIATDADREGE+IARE+L+ C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  QGSIRRLWLSALNEASIRKALTGLRPADETERLYHSALARSRADWLVGMNMSRLFTLLAQ  179
            QG + RLW+SAL++ASIR AL++L+P+  TE LY ++++RSRADWL+GMN++RLFTLL++
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RSGHHGVLSVGRVQTPTLRLVVDRDREIERFVPMHYWGIDVHLSYQEQLFLAQWVAPDCA  239
             +G   VLSVGRVQTPTL +VV RDREI+ FV+  Y  +   ++ +  LF ++WV++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCIRQAMAQQALQSVRQAQRAQVLDMQMDRIREAPPLPFDLGTLQEVCSRRFGLG  299
             D+  RCI+ ++A Q +Q  RQ+  A +++ Q++R ++++PL+F L+TLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQQTLEIAQSLYETHKATTYPRSDSGYLPESMWDEASTVLDALIISDPSVEALVQSVNRQ  359
             Q  L+IAQ LYETHK TTYPR+D GYLP SM++E + VL A++ +DP+++++V S++ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDSKVSAHHGIIPTLEPFQIEALSEKERAVYELIRAHYLAQFLPHHEYDRSCAL  419
              SR WND K++AHHGIIPT +  ++  LS+ ER VY+L+R HYLAQFLP+ E D + A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FTCGGHTLRAHGKQIVASGWHRALAPdsttsdddsAQRNQILPPLSTGSDCNVSQVELRT  479
            F  GG+ +R++G+ +V +GW   ++  S   +D++++    LP++ +G  C+V   E + 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKV  478

Query  480  LKTQAPKALTQGELIKAMKGVAKLVTDPRLKRTLKETTGIGTEATRANIISGLLNRGYLY  539
            L+T++P +  +G LI AM   A +VTD+ LK+ LKE +GIGTEATRA II  LL+RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  MKGRSVRASDAAFTLidavpaaiadpattaIWEQAFDMIENGQMTLDCFIAKQTAWITQL  599
               ++++++  +  L+D +P+++++P+ TA+WEQ +D +  G+++LD F+AKQ+ W++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VEHYRTTTLLIHTPGGPNCPLCGASMRQRQGKHGSFWSCSRYPECKGALPVVTKTT  655
            V + R+  L +++P +P CP+CG+   QR+GK G FW+C +YPECKG +    K  
Sbjct  599  VAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGP  654

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  551 bits (2080),  Expect = 4e-158, Method: Compositional matrix adjust.
 Identities = 331/650 (51%), Positives = 472/650 (73%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAVQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSMPYWAVDVLLSHAGQSFTASWIPPEGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS PY  V   ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPvaqqaadriraardaqvvSVDTERVREAPPLPFDLGTLQEVCSKQLGLD  299
             D   RC+Q  VA Q  +  R +  A +++ + ER ++++PL+F L+TLQ+ CS++ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIERLDRQ  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+P VL ++V TDP+L+P++  LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLICAHYLAQFLPHHEFDRTVAQ  419
              SR WND K++AHHGIIPT + ++LS +++ E  VY+L+  HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLppapacpqcgapmqqRTGKSGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  548 bits (2069),  Expect = 3e-157, Method: Compositional matrix adjust.
 Identities = 325/603 (54%), Positives = 460/603 (77%), Gaps = 8/603 (1%)

Query  1    MQLYLCEKPSQARDIARVLDARNRSDGYLHNATVTITWCFGHLLSMAAPEDYDPAL-KHW  59
            M+L LCEKPSQ+RDIA+ L+A +R++G+L+ + VT+TW  GHLL  A PE Y+    K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   RAEHLPFIPPAWRLVIRPEVRKQFRIIEKLLKQADAVVIATDADREGETIAREILEQCRW  119
            R++ LP++P  W+LV++++ + QF +I++LLKQ D VVIATDADREGE IARE+L+ C+ 
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDEASIHRALAALRPGDSTFPLYQAGLARARADWLVGINMTRACTLMNL  179
            +G V RLW+SALD+ASI+ ALA L+P+  T +LY AG++R+RADWL+G+N+TR  TL+  
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG-  179

Query  180  RHKG---VLSVGRVQTPTLRLVVERDREIVRFTPRPYWRVDARLHTEGTSFLAQWQPDGA  236
            R+ G   VLSVGRVQTPTL +VV RDREI  F ++PY  V A +  +G  F ++W P + 
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  237  YCDDEGRCIRESVARKAAARLQQAGTALVLDVTTRREKTPPPLAFTLSALQQFCSKQWGM  296
            YCD+E RCI+ +VA +     +Q+ TA +++    R K ++PLAF+LS+LQQ CS++WGM
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  297  GAQEVLDIAQRLYETHKATTYPRTDCVYLPLSMHAEAPQvlaalvasdaslQPLATQLNL  356
             AQ VLDIAQ+LYETHK TTYPRTDC YLPLSM+ E PQVL+A+V++D++LQP+ + L+ 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  357  QQRSRLWDDSKITAHHGIIPTRKTVDLTQLNDSERKVYGLVRSHFLAQFLPDHEVDKTDL  416
            Q  SR+W+D KITAHHGIIPT+ T DL++L+D+ER+VY LVR H+LAQFLP+ E+D T+ 
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  417  RLNCAGETLAARGSVVIVSGWRQLFLREMATQSPEET--QVLPALQQGQTCQVEQVDVRS  474
             +N +G+ + +RG+V++ +GW+ LF + M+ +  ++T    LPA+Q GQ CQV+  + + 
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGK-MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  475  RQTQPPEHYTEGTLIAAMKNAARFISDERLKQRLKENAGIGTEATRAGIIQTLLKRGYLI  534
             QT+PP  Y +GTLIAAM NAA F++D  LK+ LKENAGIGTEATRAGII+TLLKRG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  535  KQRRFLLATDTASTLIDALPEALKDPGTTALWEHMLDEIAMGKMGLEAFLVQQQEAVTAL  594
            ++++ L +T  +  L+D LP +L +PG TALWE+MLDE+A G+++L+ F+ +Q + V+ L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  595  TAQ  597
             AQ
Sbjct  599  VAQ  601

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  543 bits (2051),  Expect = 9e-156, Method: Compositional matrix adjust.
 Identities = 321/669 (48%), Positives = 488/669 (73%), Gaps = 8/669 (1%)

Query  1    MRLFLCEKPSQGKDIARVLGAKQRGDGCFHGDAITVTWCIGHLVEAAEPDAYGEQY-KSW  59
            MRL LCEKPSQG+DIA+ LGA QRG+G ++G ++TVTW  GHL+E+AEP+ YGEQY K+W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SIDQLPIIPDPWRIEIKPKTAAQLKIVKALIAQADELVIATDADREGEMIARELLELFSY  119
              D LP++P+ W++ +K+ + AQ+ +++ L+ Q DE+VIATDADREGE+IARELL+   +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRQALGALRPGSETLPLYHAALARSRADWLVGMNLSRLFTVLGR  179
            +G + RLW+SAL+DASIR AL+ L+P+S T +LY A+++RSRADWL+GMNL+RLFT+LGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYDGVLSVGRVQTPTLRLVVDRDREIARFVSVPFWTIELALSSNGQRFTAHWQAPDGS  239
            +AG + VLSVGRVQTPTL +VV RDREI  FVS P+  +  +++ NG  F + W ++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDDAGRCLQQPVAQSALATLQNARDVEVMSVDTERMREAPPLPFDLGTLQETCSRQLGLD  299
             D+  RC+Q  VA   +   +++    +++ + ER ++++PL+F L+TLQ++CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRTDCGYLPESMLADVPTILTALVRTDPSLLPLIATLDPT  359
             Q  LDIAQ LYETHK TTYPRTDCGYLP SM  ++P +L+A+V TDP+L P++A+LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKITAHHGIIPTLEPANLAAMSDKEQAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND KITAHHGIIPT + ++L+ +SD E+ VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FASGPERLTATGKQIAVIGWHSVLNEPASNEDTGDDSESPRSQTLPPLENGTRCAMEQVE  479
            F  G + + + G+ +   GW S++   + +++     ++    TLP+++ G  C ++  E
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDE-----DNTGETTLPAMQAGQVCQVQGAE  475

Query  480  LKALTTQPPRPYTQGELIKAMKGVAKLVSDPRLKQILKDTTGIGTEATRASIIQGLIARG  539
             K L T+PP PY +G LI AM   A +V+D+ LK++LK+ +GIGTEATRA+II+ L+ RG
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  YLLKKGRAVRGSDAAFTLidaipaaiadpgttaiWEQALERIEAGDMTLDAFVTRQATWV  599
            +L++  ++++++  +  L+D +P+++++PG TA+WEQ L+ + AG ++LD F+++Q+ WV
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  TQLVQHYAQTTLAIKlppsppcplcgsTMRQRTSQRGPFWSCTRYPDCKGTLPVEK--SK  657
            +QLV +     L+++ PPSPPCP+CG+   QR ++ G FW+C +YP+CKG +   +  ++
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPR  655

Query  658  TKRRAADTP  666
             +RR +  +
Sbjct  656  GRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  542 bits (2045),  Expect = 2e-155, Method: Compositional matrix adjust.
 Identities = 317/616 (52%), Positives = 452/616 (74%), Gaps = 3/616 (0%)

Query  1    MRLFLCEKPSQAKDIASVLGATRRGDGCWLGNGVTVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIA  LGAT+RG+G   G GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLDDLPIVPQQWKMRVKANTAAQFKAIKRLLGEASELVIATDADREGEMIARELLEHCRY  119
              D LP++PQQWK+ VKA++ AQF  I+RLL +  E+VIATDADREGE+IARELL+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGASTYNLYQSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  KSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVTLDGNGIPFTAVWRAPQDD  239
             +G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +  T+  NG+ F + W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDEQGRCLKQEVAQRAAEAMQGAEHAVLEKLKTERMREAPPLLFDLGTLQQVCSKKLGLG  299
            CDE+ RC++  VA +  +  + +  A + + + ER ++++PL F L+TLQQ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQKLYETDKLITYPRSDCGYLPLSQHAEAPAILAALGQADPTLREVLAHTQTQ  359
            AQ  LDIAQKLYET+KL TYPR+DCGYLPLS + E P +L+A+  +DP+L+ V+A  +TQ
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTLAAGGLTRLSGRPRAVYELIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  +G+L++LS+  R VY+L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHDLRAVGKQIVEPGWKRALPEALAPSKGREAPAPQALPALHEGQTCAVREVTLKD  479
            F+ +G+ +R+ G+ +V PGWK  +     +  + +  +  +LPA++ GQ C V+    K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  QFTQPPKPFTEGDLIQAMKNVARLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLT  539
              T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KQGKTLAATSAAFGLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLDEFVAKQSAWMARQ  599
            ++ KTL +T+ +  L+D +P ++++PG TA+WEQ LD V +G ++LD+F+AKQS W+++ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  IERCRGLQLTISGPPP  615
            + + R+  LT+ +PP+
Sbjct  599  VAQGRSQPLTMQAPPS  614

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  541 bits (2040),  Expect = 6e-155, Method: Compositional matrix adjust.
 Identities = 330/650 (51%), Positives = 474/650 (73%), Gaps = 4/650 (0%)

Query  1    MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQY-KRW  59
            MR+ LCEKPSQG+DIA+ LGA QRG+G  +G+GV VTW  GHL+E+  PE YGEQY K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   AIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGY  119
              + LP+LP++W++  KA + AQF V+++L+ + +E+VIATDADREGE+IARE++D C +
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGR  179
            +G + RLW+SAL+DASIR AL+ L PS+ T +LY+++++RSRADWLIGMNL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QAGYMGVLSVGRVQTPTLKLVVDRDREIARFVSMPYWAVDVLLSHAGQSFTASWIPPEGS  239
            +AG   VLSVGRVQTPTL +VV RDREI  FVS PY  V   ++  G  F + W+P+   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  TDAAGRCLQQPvaqqaadriraardaqvvSVDTERVREAPPLPFDLGTLQEVCSRQLGLD  299
             D   RC+Q  VA Q  +  R +  A +++ + ER ++++PL+F L+TLQ+ CSR+ G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  VQETLDIAQALYETHKATTYPRSDSGYLPESMlaevlavldallaTDPSLRPLIGQLDRN  359
             Q  LDIAQ LYETHK TTYPR+D GYLP SM  E+  VL A+++TDP+L+P+++ LD +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  QRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQ  419
              SR WND K++AHHGIIPT + ++LS +++ E  VY+L+R HYLAQFLP+ E+D T A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLK  479
            F+ G+Q + + G+ +   GW+ +++  + DD D  +      LPA++AG  C V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGE---TTLPAMQAGQVCQVQGAEQK  477

Query  480  ALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYL  539
             L+T PP PY +G LI AM   A FVTD+ LK+ L++ +GIGTEATRA II+ L+ RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEHALDMIEAGQMALDTFIEKQSVWVGQ  599
            V+  ++++++  +  L+D +P+++++PG TA+WE+ LD + AG+++LD F+ KQS WV+Q
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVQQYRGATLSLKLppapacpqcgapmqqRTGKSGAFWSCSRYPDCKGTL  649
            LV Q R+  L+++ PP+P+CP CG+   QR GKSG FW+C +YP+CKG +
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  539 bits (2035),  Expect = 1e-154, Method: Compositional matrix adjust.
 Identities = 305/645 (48%), Positives = 458/645 (72%), Gaps = 2/645 (0%)

Query  1    MRLYICEKPSQARDIARVLQAHRRGDGYLQGIGVTVTWCVGHLLETAPPETYSDQF-KRW  59
            MRL +CEKPSQ+RDIA+ L A +RG+G+L+G GVTVTW  GHLLETA PE Y++Q+ K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLEHLPIIPQHWQLVVKPKVAAQLKAISRLLQACAEVVIATDADREGEMIAREILERCQY  119
              + LP++PQ+W+LVVK+   AQ+  I+RLL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  QGPILRLWLSALDDASIRRALTALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGR  179
            QG ++RLW+SALDDASIR AL+ L+P+ +T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  RAGFDGTLPVGRVQTPTLRLVVERDRAIASFVARPFWTVDVVLHADGAEFEARWQPPAAH  239
             AG++  L+VGRVQTPTL +VV RDR I +FV++P+  V   +  +G  F ++W P+A  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDAGHCVDQaaaeqvarrlaaarSVQVERVDVERVTEGPPLPFDLGTLQEVCSAKLGLG  299
            CD+  +C++ + A QV +    + +  +   ++ER  +++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLSVAQALYETHKATTYPRSDCGYLPESMLDEVPRVlkalaaadpalaQRFKEFDPT  359
            AQ  L +AQ LYETHK TTYPR+DCGYLP SM +E+P+VL A+ ++DPAL      +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNSSKVTAHHGIIPTPVVIPLDQLSERERAVYTLIRARYLAQFLPHHEYLKTQVQ  419
              SR WN  K+TAHHGIIPT     L +LS+ ER VY L+R +YLAQFLP+ E   T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LRSQADQVLARGKQIQVRGWKAVIDETDASEPTEQTQ-RLPTLQDGASVAAHDATINTQR  478
            +   ++   +RG+ +   GWK++++     +  +  +  LP++Q G     ++A  +  +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  479  TQPPKPYTEGTLVKAMKTIANQVADMRLKQTLKDSIGIGTEATRAAIIQGLIDHGYLTKK  538
            T+PP PY +GTL+ AM   A  V+D  LK+ LK++ GIGTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  539  KRSLaasaaaHTLIEAVPREVADPVMTALWEQALARIETGQLSVEAFLAKQSAWLTQVVR  598
            K++L +++ ++ L++ +P  +++P +TALWEQ L  + +G++S++ F+AKQS W++Q+V 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  599  SQASLNLQLPRSKGPACPVCRSPMRQRKGRTGNFWSCVRYPDCKG  643
               S  L +  + +P+CPVC +   QR+G++G FW+C++YP+CKG
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG  645

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  539 bits (2034),  Expect = 2e-154, Method: Compositional matrix adjust.
 Identities = 301/657 (46%), Positives = 472/657 (72%), Gaps = 4/657 (0%)

Query  1    MRLFICEKPSQARDIARVLQASRRGDGCLTGQNLTVTWCVGHLLETAPPETYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A++RG+G L G  +TVTW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPSRWQLVAKPKVAGQLKVISQLLRTCSEVVIATDADREGEMIAREILERCQY  118
              D LP++P +W+LV K+   +Q+ VI++LL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  QGPILRLWLSALDETSIRRALSALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGR  178
            QG ++RLW+SALD++SIR AL+ L+P+ +T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RAGFDGLLPVGRVQTPTLRLVVERDRAIASFVPLPFWTVDAHLEQDGIRFHARWQAPNAV  238
             AG++ +L+VGRVQTPTL +VV RDR I +FV+ P+  V A +  +G+ F ++W ++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  SDAVGRCIDEtaaqqalrrltqaGSAQIDSVEVERVREGPPLPFDLGTLQEICSAKLGLG  298
             D   RCI+   A Q ++   Q+ +A I + ++ER ++++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQETLATAQALYETHKVTTYPRSDCGYLPESMLDEVPRVLHALAAAAPSLGEILKEVDPS  358
            AQ  L  AQ LYETHK+TTYPR+DCGYLP SM +E+P+VL A+ ++ P+L  ++  +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  359  RRSRAWNSSKITAHHGIIPTAVTLDLAQLSERERAVYTLIRARYLAQFMPEHEYLKTQAQ  418
              SR WN  KITAHHGIIPT  T DL++LS+ ER VY L+R +YLAQF+P+ E   T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  419  LHSQADHLVARGKQILARGWKAVINEADGNEPAEQAQ-RLPTLRESATVALIDATLNAQR  477
            ++  ++ + +RG+ ++  GWK+++     ++  + ++  LP+++ +    + +A  +  +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  478  TQPPKAYTEGTLVRAMKTIANQVADSRLKQKLKDSCGLGTEATRAAIIQGLIDHGYLTKK  537
            T+PP +Y +GTL+ AM   A  V+D+ LK+ LK++ G+GTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  538  KRSLaasaaaHTLIEAVPPEVADPVMTALWEQALDRIESGQLSVETFLAKQTEWLTRLVR  597
            K++L +++ ++ L++ +P  +++P +TALWEQ LD + +G++S++ F+AKQ++W+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  598  SNATLTLRPPPSKGPFCPVCRSAMRQRKGRTGSFWSCIRYPECKG-TKPVAKTKRAK  653
               +  L   ++ +P CPVC +   QR+G++G FW+C++YPECKG  +   K  R++
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGR  657

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  537 bits (2028),  Expect = 6e-154, Method: Compositional matrix adjust.
 Identities = 328/651 (51%), Positives = 459/651 (71%), Gaps = 6/651 (0%)

Query  6    MKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAF-K  64
            M+L LCEKPSQG DIAK LGAT+RGEG L+ P+  +TVTW+ GHL+E  +PE Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPG--VTVTWARGHLLETAEPEVYGEQYGK  58

Query  65   KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA  124
             W  + LP++P +W L  K ++K QF V+ +L+KQ   VVIATD DREGE IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  125  GFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRLYTLL  184
             F+G++ RLW+SALDD+SIR AL+ L  +  T +LYYAG++RSRADWLIGMN++RL+TLL
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  185  AQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIP  244
            +++ G  G+ LSVGRVQTPTL++VV+RDREI NF++K  F +   ++     F+++ V +
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPA  237

Query  245  EQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLY  304
             QYCD +  C+ + V     Q  RQ   A + + +  R +Q+APL F+LS LQ   +R  
Sbjct  238  AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHW  297

Query  305  GLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGML  364
            G+ AQ VLDIAQ LYETHK TTYPRTDCGYLP S   E PQ++  ++ +D  L+P+ + L
Sbjct  298  GMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASL  357

Query  365  NLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKT  424
            + +  SR+WNDKKITAHHGIIPT   +D+SK+SD E ++Y+L+R +YLAQFLP  E D T
Sbjct  358  DTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVT  417

Query  425  QIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAP--QALPTLKQGQICQISDSEIK  482
            +  ++ G +++ +RGNVL+ PGWK LFGK  ++D+D     +LP+++ GQ+CQ+ ++E K
Sbjct  418  EATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  483  TLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQglidkgfl  542
             LQT PP  + +GTL++AM NAA FVTD  LK+ L+E  G+GTEATRAG I+ L+ +GFL
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  543  kkkgksllATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRH  602
             +  K+L +T  +  L+D LP  L +PGLTALWEQ L+++A   +SL+ FM KQ   V +
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  603  LMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIEN  653
            L+A+   + +++       CP CG+  ++RNGK+G F GC  YP+C+ I N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  537 bits (2026),  Expect = 8e-154, Method: Compositional matrix adjust.
 Identities = 305/657 (47%), Positives = 472/657 (72%), Gaps = 5/657 (0%)

Query  1    MRLFICEKPSQARDIARVLQASHRADGCLKGQNVTITWCVGHLLETAPPETYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A++R++G L+G  VT+TW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPSQWKLVAKPKVAGQLKVISQLLRTCSEVVIATDADREGEMIAREILERCQY  118
              D LP++P QWKLV K+   +Q+ VI++LL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  QGPILRLWLSALDEASIRRALGALRPGEETLPLYHCALARSRADWLVGINLSRLFTLLGR  178
            QG ++RLW+SALD+ASIR AL+ L+P+  T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RSGFDGLLPVGRVQTPTLRLVVERDRAIASFVPLPFWTVDVHLEQDGIRFQARWQAPTAV  238
             +G++ +L+VGRVQTPTL +VV RDR I +FV+ P+  V   +  +G+ F ++W +++  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  SDAVGRCIDETaaqqaqrrfiqaGTAEIDNAEVEHVREGPPLPFDLGTLQEICSAKLGLG  298
             D   RCI+   A Q  +   Q+ TA I N ++E+ ++++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQETLATAQALYETHKATTYPRTDCGYLPESMLDEVPRVLHA-LAAAPSLGAVLKEVDPS  357
            AQ  L  AQ LYETHK TTYPRTDCGYLP SM +E+P+VL A +++ P+L +V+  +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  358  RRSRAWNSSKITAHHGIIPTAVTLDLAQLSERERAVYTLIRARYLAQFMPEHEYLKTQAL  417
              SR WN  KITAHHGIIPT  T DL++LS+ ER VY L+R +YLAQF+P+ E   T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  418  LHSQADQLVARGKQILVRGWKAVINEADGNEPAEQAQ-RLPTLRESATVALIDATLNAQR  476
            ++  ++ + +RG+ ++  GWK+++     ++  + ++  LP+++ +    + +A  +  +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  477  TQPPKAYTEGTLVKAMKTIANQVADPRLKQKLKDSCGLGTEATRAAIIQGLIDHGYLTKK  536
            T+PP +Y +GTL+ AM   A  V+D+ LK+ LK++ G+GTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  537  KRSLaasaaaHTLIEAVPPEVADPVMTALWEQALDRIESGQLSVDTFLAKQAEWLTRLVR  596
            K++L +++ ++ L++ +P  +++P +TALWEQ LD + +G++S+D F+AKQ++W+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  597  SNATLTLRPPPSKGPFCPVCRSTMRQRKGRTGSFWSCIRYPECKG-TKPVAKAKRAK  652
               +  L   ++ +P CPVC +   QR+G++G FW+C++YPECKG  +   K+ R++
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGR  657

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  537 bits (2026),  Expect = 8e-154, Method: Compositional matrix adjust.
 Identities = 305/657 (47%), Positives = 472/657 (72%), Gaps = 5/657 (0%)

Query  1    MRLFICEKPSQARDIARVLQASHRADGCLKGQNVTITWCVGHLLETAPPETYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A++R++G L+G  VT+TW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPSQWKLVAKPKVAGQLKVISQLLRTCSEVVIATDADREGEMIAREILERCQY  118
              D LP++P QWKLV K+   +Q+ VI++LL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  QGPILRLWLSALDEASIRRALGALRPGEETLPLYHCALARSRADWLVGINLSRLFTLLGR  178
            QG ++RLW+SALD+ASIR AL+ L+P+  T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RSGFDGLLPVGRVQTPTLRLVVERDRAIASFVPLPFWTVDVHLEQDGIRFQARWQAPTAV  238
             +G++ +L+VGRVQTPTL +VV RDR I +FV+ P+  V   +  +G+ F ++W +++  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  SDAVGRCIDETaaqqaqrrfiqaGTAEIDNAEVEHVREGPPLPFDLGTLQEICSAKLGLG  298
             D   RCI+   A Q  +   Q+ TA I N ++E+ ++++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQETLATAQALYETHKATTYPRTDCGYLPESMLDEVPRVLHA-LAAAPSLGAVLKEVDPS  357
            AQ  L  AQ LYETHK TTYPRTDCGYLP SM +E+P+VL A +++ P+L +V+  +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  358  RRSRAWNSSKITAHHGIIPTAVTLDLAQLSERERAVYTLIRARYLAQFMPEHEYLKTQAL  417
              SR WN  KITAHHGIIPT  T DL++LS+ ER VY L+R +YLAQF+P+ E   T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  418  LHSQADQLVARGKQILVRGWKAVINEADGNEPAEQAQ-RLPTLRESATVALIDATLNAQR  476
            ++  ++ + +RG+ ++  GWK+++     ++  + ++  LP+++ +    + +A  +  +
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  477  TQPPKAYTEGTLVKAMKTIANQVADPRLKQKLKDSCGLGTEATRAAIIQGLIDHGYLTKK  536
            T+PP +Y +GTL+ AM   A  V+D+ LK+ LK++ G+GTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  537  KRSLaasaaaHTLIEAVPPEVADPVMTALWEQALDRIESGQLSVDTFLAKQAEWLTRLVR  596
            K++L +++ ++ L++ +P  +++P +TALWEQ LD + +G++S+D F+AKQ++W+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  597  SNATLTLRPPPSKGPFCPVCRSTMRQRKGRTGSFWSCIRYPECKG-TKPVAKAKRAK  652
               +  L   ++ +P CPVC +   QR+G++G FW+C++YPECKG  +   K+ R++
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGR  657

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  537 bits (2025),  Expect = 9e-154, Method: Compositional matrix adjust.
 Identities = 328/651 (51%), Positives = 459/651 (71%), Gaps = 6/651 (0%)

Query  1    MKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAF-K  59
            M+L LCEKPSQG DIAK LGAT+RGEG L+ P+  +TVTW+ GHL+E  +PE Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPG--VTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA  119
             W  + LP++P +W L  K ++K QF V+ +L+KQ   VVIATD DREGE IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRLYTLL  179
             F+G++ RLW+SALDD+SIR AL+ L  +  T +LYYAG++RSRADWLIGMN++RL+TLL
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIP  239
            +++ G  G+ LSVGRVQTPTL++VV+RDREI NF++K  F +   ++     F+++ V +
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPA  237

Query  240  EQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLY  299
             QYCD +  C+ + V     Q  RQ   A + + +  R +Q+APL F+LS LQ   +R  
Sbjct  238  AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHW  297

Query  300  GLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGML  359
            G+ AQ VLDIAQ LYETHK TTYPRTDCGYLP S   E PQ++  ++ +D  L+P+ + L
Sbjct  298  GMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASL  357

Query  360  NLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKT  419
            + +  SR+WNDKKITAHHGIIPT   +D+SK+SD E ++Y+L+R +YLAQFLP  E D T
Sbjct  358  DTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVT  417

Query  420  QIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAP--QALPTLKQGQICQISDSEIK  477
            +  ++ G +++ +RGNVL+ PGWK LFGK  ++D+D     +LP+++ GQ+CQ+ ++E K
Sbjct  418  EATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  478  TLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQglidkgfl  537
             LQT PP  + +GTL++AM NAA FVTD  LK+ L+E  G+GTEATRAG I+ L+ +GFL
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  538  kkkgksllATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRH  597
             +  K+L +T  +  L+D LP  L +PGLTALWEQ L+++A   +SL+ FM KQ   V +
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  598  LMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIEN  648
            L+A+   + +++       CP CG+  ++RNGK+G F GC  YP+C+ I N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  537 bits (2025),  Expect = 9e-154, Method: Compositional matrix adjust.
 Identities = 328/651 (51%), Positives = 459/651 (71%), Gaps = 6/651 (0%)

Query  1    MKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAF-K  59
            M+L LCEKPSQG DIAK LGAT+RGEG L+ P+  +TVTW+ GHL+E  +PE Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPG--VTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA  119
             W  + LP++P +W L  K ++K QF V+ +L+KQ   VVIATD DREGE IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRLYTLL  179
             F+G++ RLW+SALDD+SIR AL+ L  +  T +LYYAG++RSRADWLIGMN++RL+TLL
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIP  239
            +++ G  G+ LSVGRVQTPTL++VV+RDREI NF++K  F +   ++     F+++ V +
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPA  237

Query  240  EQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLY  299
             QYCD +  C+ + V     Q  RQ   A + + +  R +Q+APL F+LS LQ   +R  
Sbjct  238  AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHW  297

Query  300  GLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGML  359
            G+ AQ VLDIAQ LYETHK TTYPRTDCGYLP S   E PQ++  ++ +D  L+P+ + L
Sbjct  298  GMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASL  357

Query  360  NLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKT  419
            + +  SR+WNDKKITAHHGIIPT   +D+SK+SD E ++Y+L+R +YLAQFLP  E D T
Sbjct  358  DTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVT  417

Query  420  QIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAP--QALPTLKQGQICQISDSEIK  477
            +  ++ G +++ +RGNVL+ PGWK LFGK  ++D+D     +LP+++ GQ+CQ+ ++E K
Sbjct  418  EATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  478  TLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQglidkgfl  537
             LQT PP  + +GTL++AM NAA FVTD  LK+ L+E  G+GTEATRAG I+ L+ +GFL
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  538  kkkgksllATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRH  597
             +  K+L +T  +  L+D LP  L +PGLTALWEQ L+++A   +SL+ FM KQ   V +
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  598  LMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIEN  648
            L+A+   + +++       CP CG+  ++RNGK+G F GC  YP+C+ I N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  535 bits (2019),  Expect = 3e-153, Method: Compositional matrix adjust.
 Identities = 328/651 (51%), Positives = 460/651 (71%), Gaps = 6/651 (0%)

Query  1    MKLFLCEKPSQGNDIAKILGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAF-K  59
            M+L LCEKPSQG DIAK+LGAT+RGEG L+ P+  +TVTW+ GHL+E  +PE Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPG--VTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   KWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLA  119
             W  + LP++P +W L  K ++K QF V+ +L+KQ   VVIATD DREGE IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GFRGQIKRLWLSALDDASIRKALGALKDNEETLPLYYAGLARSRADWLIGMNFSRIYTLL  179
             F+G++ RLW+SALDDASIR AL+ L  +  T +LYYAG++RSRADWLIGMN++R++TLL
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIP  239
            +++ G  G+ LSVGRVQTPTL++VV+RDREI NF++K  F +   ++     F+++ V +
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPA  237

Query  240  EQYCDPDGLCLSAQVIQAANQQIRQLGQAKMESVETKRERQNAPLCFALSDLQSEANRLY  299
             QYCD +  C+ + V     Q  RQ   A + + +  R +Q+APL F+LS LQ   +R  
Sbjct  238  AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHW  297

Query  300  GLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPKIIQCLLQSDNRLQPLAGML  359
            G+ AQ VLDIAQ LYETHK TTYPRTDCGYLP S   E P+++  ++ +D  LQP+ + L
Sbjct  298  GMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASL  357

Query  360  NLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKT  419
            + +  SR+WNDKKITAHHGIIPT   +D+SK+SD E ++Y+L+R +YLAQFLP  E D T
Sbjct  358  DTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVT  417

Query  420  QIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAP--QALPTLKQGQICQISDSEIK  477
            +  ++ G +++ +RGNVL+ PGWK LFGK  ++D+D     +LP+++ GQ+CQ+ ++E K
Sbjct  418  EATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  478  TLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQglidkgfl  537
             LQT PP  + +GTL++AM NAA FVTD  LK+ L+E  G+GTEATRAG I+ L+ +GFL
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  538  kkkgksllATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRH  597
             +  K+L +T  +  L+D LP  L +PGLTALWEQ L+++A   +SL+ FM KQ   V +
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  598  LMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFLGCSAYPNCQHIEN  648
            L+A+   + +++       CP CG+  ++RNGK+G F GC  YP+C+ I N
Sbjct  598  LVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVN  648

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  535 bits (2018),  Expect = 3e-153, Method: Compositional matrix adjust.
 Identities = 302/615 (50%), Positives = 451/615 (74%), Gaps = 3/615 (0%)

Query  1    MRLFLCEKPSQAKDIAKILGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK+LGA ++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPEKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALARLLPGQDTFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIEVQLEHAGLVFNAQWRAPEGI  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G++F ++W ++   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNQALAQQAATDIGNARSARVLKVTTERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ +A +++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPVSQHSEAPAILTALQRVDSSLAPLQAHLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP+S + E P +L+A+   D++L P+ A L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVTAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAE  419
              SR WND K+TAHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALAPAKGREAPPAQVLPTLCESQDCSVQGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LP++  +Q C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALAATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEDFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL+DF+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTINGPA  614
            V +  +  +T+++P+
Sbjct  599  VAQGRSQPLTMQAPP  613

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  535 bits (2019),  Expect = 3e-153, Method: Compositional matrix adjust.
 Identities = 302/657 (46%), Positives = 472/657 (72%), Gaps = 4/657 (0%)

Query  1    MRLFICEKPSQARDIARVLQASRRADGYLKGPNLIVTWCVGHLLETAPPEAYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A++R++G+L+GP + VTW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPSRWQLVAKPKVASQLKVINQLLRTCSEVVIATDADREGEMIAREILERCQY  118
              D LP++P +W+LV K+   +Q+ VIN+LL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  QGPILRLWLSALDEASIRRALGALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGR  178
            QG ++RLW+SALD+ASIR AL+ L+P+ +T +LY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RAGFDGLLPVGRVQTPTLRLVVERDRAIASFVPQPFWTLDAHLEQDGIRFHARWQPTAAA  238
             AG++ +L+VGRVQTPTL +VV RDR I +FV++P+  + A +  +G+ F ++W P+A  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  SDAVGRCIDEtaaqqalrrltqaGSAQIYSFEVERVREGPPLPFDLGMLQEICSAKLGLG  298
             D   RCI+   A Q ++   Q+ +A I + ++ER ++++PL+F L+ LQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQEALATAQALYENHKATTYPRTDCGYLPESMLDEAPRVLHalaaaaPSLGGILKEVDPS  358
            AQ  L  AQ LYE HK TTYPRTDCGYLP SM +E P+VL A+ ++ P+L  ++  +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  359  RRSRAWNSSKITAHHGIIPTAVTLDLAQLSERERAVYTLIRARYLAQFMPEHEYLKTQAL  418
              SR WN  KITAHHGIIPT  T DL++LS+ ER VY L+R +YLAQF+P+ E   T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  419  LQSQADQLIARGKQILVRGWKAVVNEADGNEPAEQAQ-RLPTLRESATVALIDATLNAQS  477
            ++  ++ + +RG+ ++  GWK++      ++  + ++  LP+++ +    + +A  +   
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  478  TQPPKAYTEGTLVKAMKTIANLVADPRLKQKLKDSCGLGTEATRAAIIQGLIDHGYLIKK  537
            T+PP +Y +GTL+ AM   A +V+D+ LK+ LK++ G+GTEATRA+II+ L+ +G+L++ 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  538  KRSLaasaaaHTLIEAVPPEVADPVMTALWEQALDRIESGQLSVETFLAKQAEWLTRLVR  597
            K++L +++ ++ L++ +P  +++P +TALWEQ LD + +G++S++ F+AKQ++W+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  598  SNATLTLRPPPSKGPFCPVCCSSMRQRKGRTGSFWSCTRYPECKG-TKPVAKAKRAK  653
               +  L   ++ +P CPVC +   QR+G++G FW+C +YPECKG  +   K+ R++
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGR  657

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  534 bits (2016),  Expect = 5e-153, Method: Compositional matrix adjust.
 Identities = 307/619 (50%), Positives = 453/619 (74%), Gaps = 4/619 (0%)

Query  1    MQLYLCEKPSQARDIAKVLGANRRGDGCLQGAGVTVTWCIGHLLETAPPDAYDPRY-KRW  59
            M+L LCEKPSQ+RDIAK LGA +RG+G L+G+GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPERWKMLVKPKTASQFKAVKRLLGECSELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T +LY A++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGTAFTAQWQAPDDY  239
            ++G   VL+VGRVQTPTL +VV RDR I +F++ P+  +   +  +G  F ++W ++ +Y
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLDqaraqqaaeamrnaacarLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ + A Q  +  R+++ A +++ + ER++++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPLSQHGEARAIVAALAQSDPTLAALEPHLDLS  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLPLS + E   +++A+  +DP+L ++ + LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVGAHHGIIPTAAVRGLERLSGRPRAVYELIRARYLAQFLPNHEYDRTQAD  419
              SR WND K+ AHHGIIPT    +L +LS+  R VY+L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKRIVEPGWKRAMPEALAPARGNREAPAPQSLPTLQQGQDYAVGEINLK  479
            F+ +GQ +R+ G+ +V PGWK         + ++ +  +  +LP++Q GQ   V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKM---SEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  DQQTHPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYL  539
              QT PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  LRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSK  599
            +R+ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G ++L++F+AKQS W+S+
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVERCAGLRMTISGPPVAA  618
            LV +  +  +T+ +PP ++
Sbjct  598  LVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  533 bits (2010),  Expect = 2e-152, Method: Compositional matrix adjust.
 Identities = 320/666 (49%), Positives = 464/666 (70%), Gaps = 10/666 (1%)

Query  1    MKLFLCEKPSQGRDIAKVLGATQKGEGYLSTADGTIVVTWARGHLVEHFSPEQYDPAL-K  59
            M+L LCEKPSQGRDIAK LGATQ+GEG+L+ ++  + VTWARGHL+E   PE Y+    K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPG--VTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   AWRLDTLPIIPSQWQVSPKPDAKKEYKTVMTLLKKARTVVISTDIDREGETIARELLDLA  119
            +WR D LP++P QW++  K+DAK ++  +  LLK+   VVI+TD DREGE IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGHIQRLWITALDEISVRKALSRLKTNEETLPLYYAGLARSRADWLIGMNFSRMFTLL  179
             ++G++ RLW++ALD+ S+R AL+ L  +  T +LYYAG++RSRADWLIGMN++R+FTLL
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQQQGYQGPPLSVGRVQSPTLALVVNRDKEIAHFVPTYHYALMVQVCGTNAQSFEASLLV  239
            +++ G  G  LSVGRVQ+PTLA+VV+RD+EI +FV+   + ++  + + N+  F +  + 
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATM-AVNGVLFPSKWVP  236

Query  240  PEQYCDEEGRCLEIKVLqqaeqqirqagqVCVQNVETKREKESPPLLFALSDLQAECNRL  299
            + QYCDEE RC++  V  Q  Q  RQ+    + N +  R K+S+PL F+LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  YDLGTQQVLDIAQSLYEKHKATTYPRTDCGYLPEAQLLEVPQVINSLMQSDAKLQPLRVQ  359
             ++ +Q VLDIAQ LYE HK TTYPRTDCGYLP +   E+PQV+++++ +D+ LQP+   
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLSQKSRAWNDKKITAHHGIIPTTQPVDIAKMNENEFKVYDLIRRRYLAQFLPHFEVDK  419
            L+    SR WNDKKITAHHGIIPT +  D++K+++ E +VY+L+R +YLAQFLP+ E+D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TRVRLSCGEHQCIAKGQVIVSAGWKALFRASKEEQGEKQG---LPILNSGQMLKVMNTEI  476
            T   ++ G +   ++G+V+V +GWK+LF    E++ ++ G   LP +++GQ+ +V  +E 
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQ  476

Query  477  KSLKTTPPAHYTEGTLLTAMVNVARFVTDERLKKQLRETEGLGTEATRASIMKTLYDRGY  536
            K L+T PPA Y +GTL++AM N A FVTD  LKK L+E  G+GTEATRA+I+ TL  RG+
Sbjct  477  KVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGF  536

Query  537  IKKKGKSIVATDAGVMLIDNLPTVLKDPGLTALWEQALNQIAENQMSLQEFMQKQEQFVL  596
            + +  K++ +T  G  L+D LP  L +PGLTALWEQ L+++A  ++SL++FM KQ Q V 
Sbjct  537  LVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVS  596

Query  597  HLIQTCGHQGIKMGNIDIKKCPQC-GKPLRKMKGKNGDFLGCTGYPKCKYIESGAKRKTS  655
            +L+     Q + M       CP C GK L++ +GK+G F GC  YP CK I + +++   
Sbjct  597  QLVAQGRSQPLTMQAPPSPPCPVCGGKTLQR-NGKSGLFWGCLKYPECKGIVNNGNKGPR  655

Query  656  AGKVTP  661
            + +  P
Sbjct  656  GRRRKP  661

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  533 bits (2013),  Expect = 7e-153, Method: Compositional matrix adjust.
 Identities = 304/611 (50%), Positives = 449/611 (74%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGAQRRGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA +RG+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   SLDDLPIIPEKWKMTVKPKTASQYKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
              D LP++P++WK+ VK+ + +Q+  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALARLLPGQETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLESAGNVFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G +F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQALAQQAAHDMQAAGSARVMKIATERVRETAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ ++A Q  +  + + +A +++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDSGYLPLSQHGEAPGILAALQRADASLAPLQPYLDPQ  359
            AQ  LDIAQ LYETHKL TYPR+D GYLPLS + E P +L+A+  +D++L P+ + LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDQKVSAHHGIIPTAAASDPSRLPPKYKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND+K++AHHGIIPT  ++D S+L+   + VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHTLRAVGKQIIEPGWRRALPEALMPQKGREAPPAQVLPALREGQDCAVQGLQLKD  479
            F+ +G+ +R+ G+ ++ PGW+  +    M++ + +      LPA++ GQ C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQNGEMSLDEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V  G +SLD+F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VQRCSGMRLTI  610
            V +  +  LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  533 bits (2013),  Expect = 8e-153, Method: Compositional matrix adjust.
 Identities = 308/619 (50%), Positives = 455/619 (74%), Gaps = 4/619 (0%)

Query  1    MQLYLCEKPSQARDIAKVLGANRRGDGCLQGAGVTVTWCIGHLLETAPPDAYDPRY-KRW  59
            M+L LCEKPSQ+RDIAK LGA +RG+G L+G+GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPERWKMLVKPKTASQFKAVKRLLGECSELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T +LY A++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGTAFTAQWQAPDDH  239
            ++G   VL+VGRVQTPTL +VV RDR I +F++ P+  +   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLDqaraqqaadamrnaasarLVKLKTERQREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ + A Q  +  R++++A +++ + ER++++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPLSQHGEARAIVAALTQADPTLAALQPHLDLS  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLPLS + E   +++A+  +DP+L ++ + LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAARGLERLSGRPRAVYELIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  + +L +LS+  R VY+L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKRIVEPGWKRAMPEALAPTRGSREAPAPQSLPALQQGQDYAVGEVNLK  479
            F+ +GQ +R+ G+ +V PGWK         + +  +  +  +LPA+Q GQ   V   + K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKM---SEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  DQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYL  539
              QT+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSK  599
            VR+ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G ++L++F+AKQS W+S+
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVERCAGLRMTISGPPVAA  618
            LV +  +  +T+ +PP ++
Sbjct  598  LVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  533 bits (2012),  Expect = 9e-153, Method: Compositional matrix adjust.
 Identities = 306/613 (50%), Positives = 449/613 (74%), Gaps = 3/613 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRRGDGCWLGPGVTVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIAK LGA +RG+G   GPGVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLGDLPIVPERWKMLVKPKTASQFKAVKRLLGEACELVIATDADREGEMIARELVEHCRY  119
              + LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGAETFSLYHSALGRSRADWLMGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWL+GMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPYWTIEVALQAGDIPFTAQWRAAEDR  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ PY  +  ++   ++ F ++W +A + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLDPEHarqaaaaigsatqaLVVKLRTERMREAPPLPFDLGTLQEICSKKLGLG  299
            CD++ RC+++  A Q       +  A +++ + ER ++++PL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYEIHKLITYPRSDCGYLPLSQHGEAPAIIAALGRSDPSLSELLTLVQPQ  359
            AQ  LDIAQ LYE HKL TYPR+DCGYLPLS + E P +++A+  +DP+L  +++ ++ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDGKVGAHHGIIPTAAATDLSRLAGKQRAVYTLVRARYLAQFLPNHEYDRTQAD  419
              SR WND K+ AHHGIIPT  + DLS+L++ +R VY LVR +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKVIVEPGWRRALPEALTPAKGREPTPAQALPPLSEGQHCNVMGVNLKD  479
            F+ +GQ +R+ G+V+V PGW+  +     +  + + T   +LP++  GQ C+V G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVARLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYLS  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KQGKALSASPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQSAWMSKQ  599
            ++ K+L ++P + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+AKQS W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCRDLRLTISG  612
            V + R   LT+ +
Sbjct  599  VAQGRSQPLTMQA  611

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  531 bits (2003),  Expect = 5e-152, Method: Compositional matrix adjust.
 Identities = 301/611 (50%), Positives = 444/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGATRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGAT++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDTWKMLVKPKTASQFKAVKRLLGEARELIIATDADREGEMIARELVEHCRY  119
                LP++P+ WK++VK+ + +QF  ++RLL +  E++IATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDTSIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDD+SIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLEHAGQRFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNQGLAQQAATAIGNAGTARAVKVTTERMREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ G+A Q      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRADASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPVLREGQDCTVQGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LP ++ GQ C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALAATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  531 bits (2002),  Expect = 6e-152, Method: Compositional matrix adjust.
 Identities = 300/611 (50%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDICVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G ++ VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPVPFWAIDVQLEHAGQRFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQSLAQQAAADIGHAGTARAVKVATERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRADASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCNVHGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C+V+G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  530 bits (2001),  Expect = 7e-152, Method: Compositional matrix adjust.
 Identities = 301/611 (50%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDICVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G ++ VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPVPFWAIDVQLEHAGQRFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQSLAQQAATDIGHAGTARAVKVATERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILSALQRADASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +LSA+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCNVHGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C+V+G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  529 bits (1996),  Expect = 2e-151, Method: Compositional matrix adjust.
 Identities = 299/611 (49%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDICVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G ++ VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPVPFWAIDVQLEHAGQRFNAQWRAPEDV  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQDLAQRAATDIGHAGTARAVKVATERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A +      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRADASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCNVNGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C+V+G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  528 bits (1994),  Expect = 2e-151, Method: Compositional matrix adjust.
 Identities = 299/611 (49%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDICVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G ++ VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPVPFWAIDVQLEHAGQRFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQDLAQRAATDIGHAGTARAVKVATERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A +      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRADASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCNVNGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C+V+G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  528 bits (1993),  Expect = 3e-151, Method: Compositional matrix adjust.
 Identities = 301/611 (50%), Positives = 445/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPEKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRGIADFVPVPFWAIDVQLEHAGFGFNAQWRAPDDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNQALAQQAAVDIGNAGTARAVKVTTERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRSDASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCTVQGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  528 bits (1991),  Expect = 4e-151, Method: Compositional matrix adjust.
 Identities = 303/611 (50%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGATRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGAT++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDTSIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDD+SIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLEHAGQAFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNQSLaqqaaaaignagtaraVKVTTERVREAAPLLFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ TA  ++   ER +++APL F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPLSQHAEAPAILAALQRADAGLAPLQPHLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLPLS + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRVWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR+WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALSEGQDCTVQGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA+  GQ C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALAATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  528 bits (1992),  Expect = 4e-151, Method: Compositional matrix adjust.
 Identities = 303/645 (47%), Positives = 470/645 (73%), Gaps = 3/645 (0%)

Query  1    MRLFICEKPSQARDIARVLQASRRGDGYLEGQNLTVTWCVGHLLETAPPETYGD-Y-KRW  58
            MRL +CEKPSQ+RDIA+ L A++RG+G+L+G  +TVTW  GHLLETA PE YG+ Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   SLDDLPIIPSQWKLVSKPKVAGQLNAISQLLRTCSEVVIATDADREGEMIAREILERCQY  118
              D LP++P QWKLV K+   +Q+  I++LL+   EVVIATDADREGE+IARE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  HGPILRLWLSALDEASIRRALSALRPGEQTLSLYHCALARSRADWLVGINLSRLFTLLGR  178
            +G ++RLW+SALD+ASIR AL+ L+P+ +T SLY  +++RSRADWL+G+NL+RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  RAGFDGLLPVGRVQTPTLRLVVERDRAIASFVPQPFWTVDAHLEQDGIRFHARWQAPTAV  238
             AG++ +L+VGRVQTPTL +VV RDR I +FV++P+  V A +  +G+ F ++W +++  
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  SDAVGRCIDEtaaqqalrrltqaGTAQIDSVEVERGREGPPLPFDLGTLQEICSAKLGLG  298
             D   RCI+   A Q ++   Q+ TA I + ++ER ++++PL+F L+TLQ+ CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AQETLATAQALYETHKATTYPRTDCGYLPESMLDEVPRVlhalaaaapslgavlKEIDPS  358
            AQ  L  AQ LYETHK TTYPRTDCGYLP SM +E+P+VL A+ ++ P+L +V+  +D  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  359  RRSRAWNSSKITAHHGIIPTAVTLDLAQLSERERAVYTLIRARYLAQLMPEHEYLKTQAL  418
              SR WN  KITAHHGIIPT  T DL++LS+ ER VY L+R +YLAQ++P+ E   T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  419  LHSQADQLVARGKQVLVRGWKAVINEADGAEPAEQAQ-RLPTLRESATVLLIDATLNAQQ  477
            ++  ++ + +RG+ ++  GWK+++      +  + ++  LP+++ +    + +A  +  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  478  TQPPKAYTEGTLVKAMKTIASQVAEPRLKQKLKDSCGLGTEATRAAIIQGLIDHGYLTKK  537
            T+PP +Y +GTL+ AM   A+ V+++ LK+ LK++ G+GTEATRA+II+ L+ +G+L + 
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  538  KRSLaasaaaHTLIEAVPPEVADPVMTALWEQALDRIESGQLSVETFLAKQAEWLTRLVR  597
            K++L +++ ++ L++ +P  +++P +TALWEQ LD + +G++S++ F+AKQ++W+++LV 
Sbjct  541  KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA  600

Query  598  SNATLTLRPPPSKGPFCPVCRSTMRQRKGRTGNFWSCIRYPECKG  642
               +  L   ++ +P CPVC +   QR+G++G FW+C++YPECKG
Sbjct  601  QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKG  645

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  525 bits (1981),  Expect = 3e-150, Method: Compositional matrix adjust.
 Identities = 299/611 (49%), Positives = 445/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPDKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIEVQLEHAAQRFNAQWRAPEDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   +  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLKQDLAQQAATDIGNAATARAVKVATERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      +++TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRADASLTPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALCEGQDCTVHGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA+  GQ C V+G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALAATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSTWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  524 bits (1978),  Expect = 5e-150, Method: Compositional matrix adjust.
 Identities = 301/618 (49%), Positives = 459/618 (75%), Gaps = 3/618 (0%)

Query  1    MRLYLCEKPSQAKDIAAVLGASRRGDGCWLGNGITVTWCIGHLLETAPPDAYDAKY-KRW  59
            MRL LCEKPSQ++DIA  LGA++RG+G   G G+TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPEKWKMLVKPKTASQFKVVKRLLGEAQELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF V++RLL + +E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGAETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVDLHHERMTFTAQWRAAEEA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ +Y  +   +  + + F ++W +A + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNPQLardaadamanaatarLVKLRTERMREVAPLPFDLGTLQEICSKKLGLG  299
            CD++ RC+++ +A +  +   +++TA +++ + ER ++ APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETHKVITYPRSDCGYLPVSQHSEAPKILAALGRADAAVNALMPHIDPQ  359
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP+S + E P++L+A+  +D+A++++++ +D Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTGAGKEVGQLTGKHRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT    ++++L++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKVVIEPGWKRALPEALTPAKGREAPVPQALPTLVQGQDYAVAKVNLKD  479
            F+ +GQ +R+ G+V++ PGWK  +     +  + +     +LP++  GQ   V   + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQ  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+AKQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VARCNGMRMTITGPASPA  617
            VA+  +  +T+ +P+SP+
Sbjct  599  VAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  524 bits (1976),  Expect = 6e-150, Method: Compositional matrix adjust.
 Identities = 301/611 (50%), Positives = 445/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERY-KRW  59
            MRL LCEKPSQ++DIAK LGA ++G+G  +G +V VTW  GHLLETA P+ Y+E+Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   NLADLPIIPEKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G V RLW+SALDDASIR ALA L P+  T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLEHAGFGFNAQWRAPDDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +   G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLNqalaqqaaaDIGNAGTARAVKVTTERVREAAPLPFDLGTLQELCSKKFGLG  299
            CD++ RC++ ++A Q      ++ TA  ++   ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRSDASLAPLQPYLEPQ  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLP S + E P +L+A+  +D++L P+ + L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  ++D S+L+  ++ VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCTVQGLQLKD  479
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C VQG + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LKE +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSAWMGKL  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G ++L++F+A+QS W+++L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VERCSGMRMTI  610
            V +  +  +T+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  523 bits (1975),  Expect = 9e-150, Method: Compositional matrix adjust.
 Identities = 322/649 (50%), Positives = 463/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAW-K  59
            M+L +CEKPSQ+RD+A  LGAT +GEG+L  +  ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGP--GVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q++V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAV  239
            ++  G  G+ LSVGRVQ+PTL++VV+RDREI NFV+K+ + +   ++  +G  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQTGLAkvvtvetkrekkSPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +QT  A ++  +  R K+S+PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPK  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   ++P+V+ ++V++D++LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDK  419
            L+ +  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E+D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK  +++ +N +E   LP +   Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FllkkkkslvasaeavalIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LD FM KQ   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  KQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL++    Q +++       C+ CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  523 bits (1975),  Expect = 9e-150, Method: Compositional matrix adjust.
 Identities = 322/649 (50%), Positives = 463/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAW-K  59
            M+L +CEKPSQ+RD+A  LGAT +GEG+L  +  ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGP--GVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q++V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAV  239
            ++  G  G+ LSVGRVQ+PTL++VV+RDREI NFV+K+ + +   ++  +G  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQTGLAkvvtvetkrekkSPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +QT  A ++  +  R K+S+PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPK  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   ++P+V+ ++V++D++LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDK  419
            L+ +  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E+D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK  +++ +N +E   LP +   Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FllkkkkslvasaeavalIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LD FM KQ   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  KQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL++    Q +++       C+ CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  523 bits (1975),  Expect = 9e-150, Method: Compositional matrix adjust.
 Identities = 322/649 (50%), Positives = 463/649 (72%), Gaps = 6/649 (0%)

Query  1    MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAW-K  59
            M+L +CEKPSQ+RD+A  LGAT +GEG+L  +  ++ VTW+ GHL+E  +PE Y+E   K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGP--GVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   RWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLA  119
             W  + LP++P QWK+  K ++K Q++V+  L+K+   VVIATDADREGE+IARELLD  
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLM  179
             ++G++ R W+SALDDASIR AL  L ++  TE+LYYAG+GRSR+DWLIGMN++RLFTL+
Sbjct  119  KFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLL  178

Query  180  AQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAV  239
            ++  G  G+ LSVGRVQ+PTL++VV+RDREI NFV+K+ + +   ++  +G  F +    
Sbjct  179  GREAGI-GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSKWVP  236

Query  240  PEQYLDESGLCLDSRVIQQAEAQIKQTGLAkvvtvetkrekkSPPLLYALSDLQGECNRL  299
            + QY DE   C++S V  Q     +QT  A ++  +  R K+S+PL ++LS LQ  C+R 
Sbjct  237  AAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRH  296

Query  300  FGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPK  359
             G  AQ VLDIAQ LYE HK+TTYPRTDCGYLP S   ++P+V+ ++V++D++LQ +++ 
Sbjct  297  WGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVAS  356

Query  360  LNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDK  419
            L+ +  SR W+DKKITAHHGIIPT   +DLSKLS+ E +VY+L+R +YLAQFLP++E+D 
Sbjct  357  LDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  420  TVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSE  479
            T AT++ +G+ + +RGNV+V  GW+ LFGK  +++ +N +E   LP +   Q C+V  +E
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAE  475

Query  480  VRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKG  539
             + LQTKPPA Y +GTL+ AM NAA FVTD+ LK+ L+E  G+GTEATRAG+I+ L+ +G
Sbjct  476  QKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRG  535

Query  540  FllkkkkslvasaeavalIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFV  599
            FL++ KK+L +++ +  L+D LP+ L NPGLTALWEQ L+++A G ++LD FM KQ   V
Sbjct  536  FLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWV  595

Query  600  KQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQ  648
             QL++    Q +++       C+ CG    + N   G FWGC  YP+C+
Sbjct  596  SQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  522 bits (1971),  Expect = 2e-149, Method: Compositional matrix adjust.
 Identities = 304/618 (50%), Positives = 453/618 (74%), Gaps = 3/618 (0%)

Query  1    MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARY-KRW  59
            M+L LCEKPSQ++DIA  LGAT+RG+G   GPG+TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRY  119
                LP++P QWK+ VK+ + +Q+  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALD+ASIR ALA L P++ T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVQLSHEGTAFTAQWRADPDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ +Y  +   ++ +G  F ++W + ++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQERClnqalardaaqamanattarTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ ++A +  Q   ++ TA  ++ + ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEapailaalaqaDPSLAPLREHLQPQ  359
            AQ  LDIAQ LYET KL TYPR+DCG+LPLS + E P +L+A+  +DP+L P+   L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  + +L KL++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPTPQTLPALSEGRDCAVDEVKPKD  479
            F+ +GQ +R+ G+ +V PGWK  +     +  + +     TLPA+  G+ C V+    K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKH  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+++Q+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VARCQGMSLTISGPASPA  617
            VA+ ++ +LT+ +P+SP+
Sbjct  599  VAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  522 bits (1969),  Expect = 2e-149, Method: Compositional matrix adjust.
 Identities = 304/611 (50%), Positives = 446/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLYLCEKPSQAKDIAAVLGARRRGDGCWLGTDVTVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIA  LGA +RG+G   G +VTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIIPEKWKMTVKPRTASQYKAVKRLLGEAAELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK+ VK+ + +Q+  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDDASIRKALAALKPGNETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPYWAIDVQLLHNGTAFTAQWRAASEV  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ PY  +   +  NG  F ++W +A++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNqalaqqaadamrgaasaRVIKLRTERMREVAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ ++A Q  +  R +++A +I+ + ER ++ APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETYKVITYPRSDCGYLPLSQHNEAPAILAALRQADPALNTLHDHLDPQ  359
            AQ  LDIAQ LYET K+ TYPR+DCGYLPLS ++E P +L+A+  +DPAL+ +   LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAAKNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  + +L KL++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKQIIEQGWKRALPEALAATKGREAPAPQTLPNLAEGIDCAVAGVQLKD  479
            F+ +GQ +R+ G+ ++  GWK  +     +  + +  +  TLP +  G  C V G + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALAATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTKQAAWMSKQ  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F++KQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VSRCAGLSLTI  610
            V++  + +LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  522 bits (1968),  Expect = 3e-149, Method: Compositional matrix adjust.
 Identities = 302/618 (49%), Positives = 454/618 (74%), Gaps = 3/618 (0%)

Query  1    MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARY-KRW  59
            M+L LCEKPSQ++DIA  LGAT+RG+G   GPG+TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRY  119
                LP++P QWK+ VK+ + +Q+  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALD+ASIR ALA L P++ T +LY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPIAYWAIDVQLSHEGTAFTAQWRADPDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ +Y  +   ++ +G  F ++W + ++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQERClnqalardaamamsnaasarTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ ++A +      ++++A  ++ + ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEapailaalaqaDPSLAPLREHLQPQ  359
            AQ  LDIAQ LYET KL TYPR+DCG+LPLS + E P +L+A+  +DP+L P+   L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  + +L KL++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPAPQTLPALAEGRDCAVDEVKPKD  479
            F+ +GQ +R+ G+ +V PGWK  +     +  + +  +  TLPA+  G+ C V+    K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKH  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+++Q+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VARCQGMSLTISGPASPA  617
            VA+ ++ +LT+ +P+SP+
Sbjct  599  VAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  520 bits (1962),  Expect = 9e-149, Method: Compositional matrix adjust.
 Identities = 300/611 (50%), Positives = 439/611 (72%), Gaps = 3/611 (0%)

Query  4    MRLFLCEKPSQAKDIAKVLQATRRGDGCWLGPDLAVTWCIGHLLETAPPDAYDARY-KRW  62
            MRL LCEKPSQ++DIAK L AT+RG+G   GP+++VTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  63   DLSDLPIVPEHWKMLVKPKTASQYKVIKRLLGECRELIIATDADREGEMIARELVEHCRY  122
                LP++P++WK++VK+ + +Q+ VI+RLL +  E++IATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  123  RGPIRRLWLSALDDASIRKALAALKPGTETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  182
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  183  QSGYQGVLSVGRVQTPTLRLVVDRDRSIADFVPVPWWAIEVQLLAEGTPFTAQWRAPEDA  242
            ++G   VLSVGRVQTPTL +VV RDR I +FV+ P   +   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  243  CDDQGRCLKQELAQQAAQDMRHAGSARLVALKTERIREMPPLPFDLGTLQEICSKKLGLG  302
            CD++ RC++  +A Q  Q  R++ +A ++  + ER ++ +PL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  303  AQETLDIAQALYETHKVITYPRSDCGYLPQSQHGEAPAILAALERTDPALAGLMHHIDPR  362
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E P +L+A+  TDPAL  ++  +D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  363  RRSRAWNDARVGAHHGIIPTAAAQSLDRLVGKQCAVYTLIRARYLAQFLPNHEYDRTQAD  422
              SR WND ++ AHHGIIPT  +  L +L + +  VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  423  FDCAGHALRAVGKRIVEPGWRRALPEALTPAKGRETPPSQELPALREGQDCAVAEVTLKD  482
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C V     K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  483  LWTQPPKPYTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQALIERGYLL  542
            L T+PP PY +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII++L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  543  KQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMSLEAFVAKQSAWMSKL  602
            ++ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G +SL+ F+AKQS W+S+L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  603  IERCAGLRLTI  613
            + +  +  LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  520 bits (1962),  Expect = 9e-149, Method: Compositional matrix adjust.
 Identities = 300/611 (50%), Positives = 439/611 (72%), Gaps = 3/611 (0%)

Query  4    MRLFLCEKPSQAKDIAKVLQATRRGDGCWLGPDLAVTWCIGHLLETAPPDAYDARY-KRW  62
            MRL LCEKPSQ++DIAK L AT+RG+G   GP+++VTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  63   DLSDLPIVPEHWKMLVKPKTASQYKVIKRLLGECRELIIATDADREGEMIARELVEHCRY  122
                LP++P++WK++VK+ + +Q+ VI+RLL +  E++IATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  123  RGPIRRLWLSALDDASIRKALAALKPGTETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  182
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  183  QSGYQGVLSVGRVQTPTLRLVVDRDRSIADFVPVPWWAIEVQLLAEGTPFTAQWRAPEDA  242
            ++G   VLSVGRVQTPTL +VV RDR I +FV+ P   +   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  243  CDDQGRCLKQELAQQAAQDMRHAGSARLVALKTERIREMPPLPFDLGTLQEICSKKLGLG  302
            CD++ RC++  +A Q  Q  R++ +A ++  + ER ++ +PL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  303  AQETLDIAQALYETHKVITYPRSDCGYLPQSQHGEAPAILAALERTDPALAGLMHHIDPR  362
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E P +L+A+  TDPAL  ++  +D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  363  RRSRAWNDARVGAHHGIIPTAAAQSLDRLVGKQCAVYTLIRARYLAQFLPNHEYDRTQAD  422
              SR WND ++ AHHGIIPT  +  L +L + +  VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  423  FDCAGHALRAVGKRIVEPGWRRALPEALTPAKGRETPPSQELPALREGQDCAVAEVTLKD  482
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C V     K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  483  LWTQPPKPYTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQALIERGYLL  542
            L T+PP PY +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII++L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  543  KQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMSLEAFVAKQSAWMSKL  602
            ++ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G +SL+ F+AKQS W+S+L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  603  IERCAGLRLTI  613
            + +  +  LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  520 bits (1962),  Expect = 9e-149, Method: Compositional matrix adjust.
 Identities = 300/611 (50%), Positives = 439/611 (72%), Gaps = 3/611 (0%)

Query  4    MRLFLCEKPSQAKDIAKVLQATRRGDGCWLGPDLAVTWCIGHLLETAPPDAYDARY-KRW  62
            MRL LCEKPSQ++DIAK L AT+RG+G   GP+++VTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  63   DLSDLPIVPEHWKMLVKPKTASQYKVIKRLLGECRELIIATDADREGEMIARELVEHCRY  122
                LP++P++WK++VK+ + +Q+ VI+RLL +  E++IATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  123  RGPIRRLWLSALDDASIRKALAALKPGTETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  182
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  183  QSGYQGVLSVGRVQTPTLRLVVDRDRSIADFVPVPWWAIEVQLLAEGTPFTAQWRAPEDA  242
            ++G   VLSVGRVQTPTL +VV RDR I +FV+ P   +   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  243  CDDQGRCLKQELAQQAAQDMRHAGSARLVALKTERIREMPPLPFDLGTLQEICSKKLGLG  302
            CD++ RC++  +A Q  Q  R++ +A ++  + ER ++ +PL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  303  AQETLDIAQALYETHKVITYPRSDCGYLPQSQHGEAPAILAALERTDPALAGLMHHIDPR  362
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E P +L+A+  TDPAL  ++  +D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  363  RRSRAWNDARVGAHHGIIPTAAAQSLDRLVGKQCAVYTLIRARYLAQFLPNHEYDRTQAD  422
              SR WND ++ AHHGIIPT  +  L +L + +  VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  423  FDCAGHALRAVGKRIVEPGWRRALPEALTPAKGRETPPSQELPALREGQDCAVAEVTLKD  482
            F+ +G+ +R+ G+ +V PGW+  +     +  + +      LPA++ GQ C V     K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  483  LWTQPPKPYTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQALIERGYLL  542
            L T+PP PY +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII++L+ RG+L+
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  543  KQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMSLEAFVAKQSAWMSKL  602
            ++ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G +SL+ F+AKQS W+S+L
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  603  IERCAGLRLTI  613
            + +  +  LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  518 bits (1954),  Expect = 4e-148, Method: Compositional matrix adjust.
 Identities = 306/619 (50%), Positives = 454/619 (74%), Gaps = 4/619 (0%)

Query  1    MQLYLCEKPSQARDIAKVLGANRRGDGCLQGAGVTVTWCIGHLLETAPPDAYDPRY-KRW  59
            M+L LCEKPSQ+RDIAK LGA +RG+G L+G+GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPERWKMLVKPKTASQFKAVKRLLGECSELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T +LY A++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGAAFTAQWQAPDDL  239
            ++G   VL+VGRVQTPTL +VV RDR I +F++ P+  +   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLDqaraqqaadamrnaasarLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ + A Q  +  R++++A +++ + ER++++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPLSQHGEARAIVAALTQADPTLAALQPHLDLS  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLPLS + E   +++A+  +DP+L ++ + LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVGAHHGIIPTaaarglerlagrpraVYELIRARYLAQFLPNHEYDRTQAD  419
              SR WND K+ AHHGIIPT  + +L +L++  R VY+L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKRVVEPGWKRAMPEALAPARGNREEHAPQSLPALQQGGDYAVGEITLK  479
            F+ +GQ +R+ G+ +V PGWK         + ++ ++ +  +LPA+Q G    V     K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKM---SEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  DQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYL  539
              QT+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSK  599
            VR+ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G ++L++F+AKQS W+S+
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVERCAGLRMTISGPPVAA  618
            LV +  +  +T+ +PP ++
Sbjct  598  LVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  517 bits (1949),  Expect = 9e-148, Method: Compositional matrix adjust.
 Identities = 297/618 (49%), Positives = 456/618 (74%), Gaps = 3/618 (0%)

Query  1    MRLYLCEKPSQAKDIAAVLGASRRGDGCWLGNGVTVTWCIGHLLETAPPDAYDAKY-KRW  59
            MRL LCEKPSQ++DIA  LGA++RG+G   G GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPEKWKMLVKPKTASQYKAVKRLLGEAQELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +Q+  ++RLL + +E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGAETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVDLRHEHMTFTAQWRAPDDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ +Y  +   +  + + F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNPQlardaadamlnaatarlVKLRTERMREVAPLPFDLGTLQEICSKKLGLG  299
            CD++ RC+++ +A +  +   +++TA +++ + ER ++ APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETHKAITYPRSDCGYLPLSQHSEAPKILAALGRADTAVNELMSHIDPR  359
            AQ  LDIAQ LYETHK  TYPR+DCGYLPLS + E P++L+A+  +D A++ +++ +D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTGAGKEVSQLTGKHRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT    ++S+L++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  LDCAGHALRAVGKVIIEPGWKRALPEALAPAKGREAPAPQALPTLVQGHDYAVAKVNLKD  479
            ++ +G+ +R+ G+V++ PGWK  +     +  + +  +  +LP++  G+   V   + K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLV  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFIAKQAAWMSKQ  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+AKQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VARCNGMRMTITGPASPA  617
            VA+  +  +T+ +P+SP+
Sbjct  599  VAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  515 bits (1943),  Expect = 3e-147, Method: Compositional matrix adjust.
 Identities = 293/611 (48%), Positives = 444/611 (73%), Gaps = 3/611 (0%)

Query  1    MRLYLCEKPSQAKDIAAVLGAKRRGDGCWLGTDVTVTWCIGHLLETAPPDAYDAKY-KRW  59
            MRL LCEKPSQ++DIA  LGA +RG+G   G +VTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIIPDKWKMTVKPRTASQYKAVKRLLGEASELIIATDADREGEMIARELVEHCRY  119
                LP++P++WK+ VK+ + +Q+  ++RLL +  E++IATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDEASIRKALAALKPGAETFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALD+ASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVQLLHGDTPFNAQWRAPNDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ +Y  +   +   +  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNqalaqqaaaaissaasaRVVKLRTERMREVAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ ++A Q       +++A +++ + ER ++ APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETYKVITYPRSDCGYLPLSQHNEAPGILAALRQADPSLEALREHLEPQ  359
            AQ  LDIAQ LYET K+ TYPR+DCGYLPLS ++E P +L+A+  +DP+L+++   L+ Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVSAHHGIIPTAAAKNLERLTGKHRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K++AHHGIIPT  + +L +L++ +R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGEALRAVGKQIIEPGWKRALPEALAPAKGREAPAPQTLPTLTQGAECAVADVKLKD  479
            F+ +G+ +R+ G+ ++ PGWK  +     +  + +  +  TLP++  G  C V +   K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKV  478

Query  480  LWTQPPKPYTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLV  539
            L T+PP PY +G LI AM N A +V D+ LK+ LK+ +GIGTEATRA+II+ LL RG+LV
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTKQAAWMSKQ  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F++KQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VTRCAGLSLTI  610
            V++  + +LT+
Sbjct  599  VAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  513 bits (1937),  Expect = 7e-147, Method: Compositional matrix adjust.
 Identities = 282/588 (48%), Positives = 436/588 (75%), Gaps = 5/588 (0%)

Query  1    MPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPI  60
            +P++PQ+W++ VK+ + +QF V++ LL +  ++VIATDADREGE+IARE+++ C ++G +
Sbjct  65   LPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRV  124

Query  61   ERLWLSALNDASIRAALGKLRPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGRQAGY  120
             RLW+SAL+DASIR+AL+ L+PS+ T ++Y ++++RSRADWL+GMNL+RLFT+LGR+AG 
Sbjct  125  FRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGI  184

Query  121  DGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLSAGVQAFTAHWVPPNACTDDA  180
            + VLSVGRVQTPTL +VV RDREI  FVS PY  ++ +++     F + WVP+    D+ 
Sbjct  185  GNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEE  244

Query  181  GRCLqqpvaqqamqqIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQET  240
             RC+Q  VA Q +Q  R + +A +++ + ER ++++PL+F L+TLQ+ CS++ G+  Q  
Sbjct  245  KRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTV  304

Query  241  LEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRLQRSR  300
            L+IAQ LYETHK TTYPR+D GYLP SM  E+  VL +++ TDP+L+++++ LD    SR
Sbjct  305  LDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSR  364

Query  301  AWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAKLSCG  360
             WND K+TAHHGIIPT + ++LS +S+ E  VY+L+R HYLAQFLP+ E+D T A ++ G
Sbjct  365  IWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIG  424

Query  361  GQNLAATGKQVVTPGWRQVLAEPQSEdgdgdgdTAARAQVLPALHEGLACQVADIDLKAL  420
            GQ + + G+ +V PGW+ +++    +D D  G+T+     LPA++ G  CQV + + K L
Sbjct  425  GQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT-----LPAMQAGQVCQVQGAEQKVL  479

Query  421  KTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVK  480
            +T PP PY +G L+ +M   A +V+D+ LK+ LK+  GIGTEATRA II+ L+ RG+LV+
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  481  KGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLI  540
              ++++++  +  L+D +P+++++PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL+
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  541  AQYGNASLSIKAPQGPTCPQCGAPTRQRSSKSGPFWSCSRYPDCKGTL  588
            AQ  + +L+++AP +P CP CG+ T QR++KSG FW+C +YP+CKG +
Sbjct  600  AQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  512 bits (1933),  Expect = 2e-146, Method: Compositional matrix adjust.
 Identities = 329/698 (48%), Positives = 476/698 (69%), Gaps = 36/698 (5%)

Query  1    MILYLCEKPSQGRDIGRVLGATSRHEGYVAGAGVCVTWCIGHLMEMVAPDGYRPEW-KSW  59
            M L LCEKPSQGRDI++ LGAT R EG++ G+GV VTW  GHL+E   P+ Y  +  K+W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   RLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQY  119
            R D LP++PQQW+L + A ++ QF VI+ LLK V EVV+ATDADREGE I+RE+L+ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAYTLLGR  179
            +G++ RLW+SALDDASIR AL++L P+ +TE+LY AG+GRSRADW++GMNLTR +TLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFALHRVHSGTFIAKWVPPPKP  239
            ++G + VLSVGRVQTPTL +VV RDR I+NF +  YFE++A   V++  F +KWVP+++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDAEGHCLDRTLAETVIHKV-QGHSGTITKAETKRVKeppplplelSTLQQEASRRWGMG  298
            CD E +C++  +A  V++   Q  +++I + +  R K+++PL++ LSTLQQ  SR+WGM 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  299  AKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTPLVEGADAQ  358
            A+  L+IAQ LYE HK  TYPRTDC YLP +   E P VL ++   D++L P+V + D+Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  359  LRSKAWNDKkitahhaiiptaakiNIDALSREEALLYDLIRRHYLAQFYPPFEYDRTVID  418
            + S+ WNDKKITAHH+IIPT    ++  LS  E  +Y+L+R HYLAQF P  E D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  419  TQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIEGAELKQKQ  478
             +++ + F++ G V + PGWK +++   E  E++ +E TLP +++G+   ++GAE K  Q
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ  480

Query  479  TKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILETLIKRNLLAKQ  538
            TKPP  Y +GTLI AM + + +V DA L+K+L+E +GIGTEATRA+I++TL+KR +L ++
Sbjct  481  TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE  540

Query  539  GKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLAKSELWLNKLI  598
             KK+L S P GR LVD LP ++T+P+ TA+WEQ LD++A G  SL+ F+AK   W+++L+
Sbjct  541  -KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  599  HNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRSKAEVTPTPNAAPLCPQCGGPMLQ  658
               + R Q          P T ++ P+ P                     CP CGG  LQ
Sbjct  600  --AQGRSQ----------PLTMQAPPSPP---------------------CPVCGGKTLQ  626

Query  659  RKSPQGAFWSCAEQATCTGTRPGSPLAAHSPLMQPNPE  696
            R++  G FW+C   + C G    +  ++++   +P+P 
Sbjct  627  RNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA  664


 Score = 34.0 bits (109),  Expect = 0.031, Method: Compositional matrix adjust.
 Identities = 19/44 (44%), Positives = 26/44 (60%), Gaps = 8/44 (18%)

Query  691  MQPNPERGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCR  734
            MQ+ P  +P CP C    L QR    GK++   FWGC +YP+C+
Sbjct  609  MQAPP--SPPCPVCGGKTL-QRN---GKSG--LFWGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  510 bits (1925),  Expect = 6e-146, Method: Compositional matrix adjust.
 Identities = 292/556 (53%), Positives = 418/556 (76%), Gaps = 6/556 (1%)

Query  2    AAPEDYDPAL-KHWRAEHLPFIPPAWRLVIRPEVRKQFRIIEKLLKQADAVVIATDADRE  60
            A PE Y+    K WR++ LP++P  W+LV++++ + QF +I++LLKQ D VVIATDADRE
Sbjct  47   AEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADRE  106

Query  61   GETIAREILEQCRWRGPVQRLWLSALDDASIHKALAAMRSGDSTYPLYQAGLARARADWL  120
            GE IARE+L+ C+ +G V RLW+SALDDASI+ ALA ++++  T +LY AG++R+RADWL
Sbjct  107  GEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWL  166

Query  121  VGINMTRACTLMNRRHK--GVLSVGRVQTPTLRLVVERDREISRFTPRPWWRVDARLHAE  178
            +G+N+TR  TL+ R      VLSVGRVQTPTL +VV RDREI  F ++P   V A +  +
Sbjct  167  IGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVN  226

Query  179  GTTFLAQWQPDGVYCDDEGRCIRESAAREATASLQQAGTTLVLDVTTRREKTPPPLAFTL  238
            G  F ++W P + YCD+E RCI+ + A +     +Q+ T+ +++    R K ++PLAF+L
Sbjct  227  GVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSL  286

Query  239  SALQQVCSKQWGMGAQEVLDIAQRLYETHKATTYPRTDCGWLPLSMHTEAPQVLAALVAS  298
            S+LQQ CS++WGM AQ VLDIAQ+LYETHK TTYPRTDCG LPLSM+ E PQVL+A+V++
Sbjct  287  STLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGT  346

Query  299  DISLQPLATQLNLQQHSRLWDDSKITAHHGIIPTRKTVDLTQMNDSERKVYGLVRSHFLA  358
            D +LQP+ + L+ Q  SR+W+D KITAHHGIIPT+ T DL++++D+ER+VY LVR H+LA
Sbjct  347  DPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLA  406

Query  359  QFLSDHEVDKTDLRLNCAGETLAARGSVVIVSGWQQLFLREMATHSPEET--QSLPVLQQ  416
            QFL++ E+D T+  +N +G+ + +RG+V++ +GW+ LF + M+ +  ++T   +LP +Q 
Sbjct  407  QFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGK-MSEDDEDNTGETTLPAMQA  465

Query  417  GQTCQVEQVDVRARQTQPPEHYTEGTLIAAMKNAARFVSDERLKQRLKENAGIGTEATRA  476
            GQ CQV+  + +  QT+PP  Y +GTLIAAM NAA FV+D  LK+ LKENAGIGTEATRA
Sbjct  466  GQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRA  525

Query  477  GIIQTLLKRGYLIKQRRFLLATDTASALIDALPEKLKDPGTTALWEQMLDDIATGKMGLE  536
            GII+TLLKRG+L+++++ L +T  +  L+D LP  L +PG TALWEQMLD++A+G+++L+
Sbjct  526  GIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLD  585

Query  537  AFLVQQQETVTALTAQ  552
             F+ +Q + V+ L AQ
Sbjct  586  DFMAKQSQWVSQLVAQ  601

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  508 bits (1916),  Expect = 4e-145, Method: Compositional matrix adjust.
 Identities = 304/652 (47%), Positives = 453/652 (70%), Gaps = 25/652 (3%)

Query  6    LCEKPSQGQDIARVLGATRKGNGCRSTQSEEVVVTWCFGHLLEMPPPEAYDPAL-KSWAL  64
            LCEKPSQG+DIA+ LGAT++G+G    ++  V VTW  GHLLE + PE Y+    K+W  
Sbjct  5    LCEKPSQGRDIAKFLGATQRGEG--FLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRT  62

Query  65   DTLPIIPEQWRLVVKPSAQRQFTVIKKWLGSASRLVIATDADREGEVIAREVMALCGYRG  124
            D LP++P+QW+LVVK+ A+ QF+VI++ L     +VIATDADREGEVIARE++  C ++G
Sbjct  63   DVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQG  122

Query  125  PVQRLWLSALNDASIRKALSQLRDGKQTYPLYLAGMARARADWLVGMNLTRAYTVLGRNA  184
             V RLW+SAL+DASIR AL++L+ + +T +LY AG++R+RADWL+GMNLTR +T+LGR+A
Sbjct  123  RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREA  182

Query  185  GYQGVLSVGRVQTPTLRLVVDRDRAIEAFKPSPYWTITSTLSAQGAAAPAFRAHWQPAAE  244
            G   VLSVGRVQTPTL +VV RDR I+ F + PY  + +T++ +G     F + W PAA+
Sbjct  183  GIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV---LFPSKWVPAAQ  239

Query  245  HCDSQGRCINETVARTVAQQCSVTGAQAHVTDSKKERKAAPPPLPFDLNSLQQEAGKRFD  304
             CD + RCI+  VA  V Q C  T + A + + + ERK  ++PL+F L++LQQ  +++ +
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAA-IINCQIERKKQSAPLAFSLSTLQQACSRHWG  298

Query  305  LSGNQVLEAAQALYETHKITSYPRTECRHLPTSMHGEAPDVLRAVLAMEPELTSIQSMLD  364
            ++++ VL+ AQ LYETHK+T+YPRT+C  LP SM+ E P+VL AV++ +P L ++ + LD
Sbjct  299  MPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLD  358

Query  365  MSRRTKTWNDTEVEKASHHGIIPTAESADLTRLSTTERQVYGLIRRHYLIQFLPDHQYDA  424
                ++ WND  +  ++HHGIIPT +++DL++LS +ER+VY L+R HYL QFLP+ + D 
Sbjct  359  TQFVSRIWNDKKI--TAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDV  416

Query  425  TTLTLSVQGHPFLAKGKATVEPGWTRLFPSSKSTPqdgddqqdgsgdqgTVPALPEGTSC  484
            T  T+++ G+ F ++G+  V PGW  LF             ++++ ++ T+PA+  G  C
Sbjct  417  TEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSED-------DEDNTGETTLPAMQAGQVC  469

Query  485  AIQSVDCDRKMTTPPARYTDGTLIAAMKNIAKMVTDPKLRAVLRDTAGLGTGATRANIIA  544
             +Q+ +     T PPA Y DGTLIAAM N A  VTD+ L+ VL++ AG+GT ATRA II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  545  TLKKRGFIEKKRGHLVSTEQGRQLIDALPSAITNPDTTAAWEQALEDIATGTGTLDEFMR  604
            TL KRGF+ + +  L ST  GR+L+D LP+++TNP+ TA WEQ L+++A+G  +LD+FM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  605  RQLDWLNTVVTHAKGQTLSALAATVKDNALPCQ-CGGSATE-TAKS---WRC  651
            +Q +W++ +V+++++Q L+  A+     + PC  CGG + +  +KS   W C
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPP----SPPCPVCGGKTLQRNGKSGLFWGC  637

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  506 bits (1909),  Expect = 1e-144, Method: Compositional matrix adjust.
 Identities = 308/619 (50%), Positives = 455/619 (74%), Gaps = 4/619 (0%)

Query  1    MQLYLCEKPSQARDIAKVLGANRRGDGCLQGAGVTVTWCIGHLLETAPPDAYDPRY-KRW  59
            M+L LCEKPSQ+RDIAK LGA +RG+G L+G+GVTVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLADLPIVPERWKMLVKPKTASQFKAVKRLLGECSELVIATDADREGEMIARELVEHCRY  119
                LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T +LY A++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAVDVQLLADGAAFIAQWQAPDDH  239
            ++G   VL+VGRVQTPTL +VV RDR I +F++ P+  V   +  +G  F ++W ++ + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQGRCLDqaraqqaadamrnaasarLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLG  299
            CD++ RC++ + A Q  +  R++++A +++ + ER++++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQALYETHKLITYPRSDCGYLPLSQHGEARAIVAALTQADPTLAALQPHLDLS  359
            AQ  LDIAQ LYETHKL TYPR+DCGYLPLS + E   +++A+  +DP+L ++ + LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVGAHHGIIPTaaarglerlagrprTVYELIRARYLAQFLPNHEYDRTQAD  419
              SR WND K+ AHHGIIPT  + +L +L++  R VY+L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKRVVEPGWKRAMPEALAPARGNREaaapqslpalqqgqDYAVGEIKLK  479
            F+ +GQ +R+ G+ +V PGWK         + ++ + ++  +LPA+Q GQ   V     K
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKM---SEDDEDNTGETTLPAMQAGQVCQVQGAEQK  477

Query  480  DQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYL  539
              QT+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L
Sbjct  478  VLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFL  537

Query  540  VRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSK  599
            VR+ K+L +TP + +L+D +P  +++PG TA+WEQ LD V +G ++L++F+AKQS W+S+
Sbjct  538  VREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQ  597

Query  600  LVERCAGLRMTISGPPVAA  618
            LV +  +  +T+ +PP ++
Sbjct  598  LVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  500 bits (1887),  Expect = 8e-143, Method: Compositional matrix adjust.
 Identities = 301/618 (49%), Positives = 445/618 (73%), Gaps = 3/618 (0%)

Query  1    MRLFLCEKPSQAKDIAAALGATRRGDGCWVGANATVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIA  LGAT+RG+G   G+  TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEATELVIATDADREGEMIARELIEHCRY  119
              + LP++P++WK++VK+ + +QF  ++RLL +  E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPAPYWAIDVRLLHDNQAFIAQWRAPSDA  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ PY  +   +  +   F ++W ++++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNqalaqqaaqamraaasaRLVKLRTERIREAAPLPFDLGTLQEICSKKLGLG  299
            CD++ RC++ ++A Q  Q  R +++A +++ + ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIIAALCKADPALANLSPHLDPQ  359
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E + +++A+  +DPAL  + + LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDSKVTAHHGIIPTAAVRGVERLSGKPRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K+TAHHGIIPT    ++ +LS+  R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWKRAMPEALAPAKGREapapqplpalFQGCECAVAEVILKD  479
            F+ +G+ +R+ G+ +V PGWK           +  + +  P     Q C+   AE   K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQ--KV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLT  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KQGKSLCAAPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQ  599
            ++ K+L ++P + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+AKQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VSRCVGMRMSISGPASPA  617
            V++  +  +++ +P+SP+
Sbjct  599  VAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  497 bits (1873),  Expect = 1e-141, Method: Compositional matrix adjust.
 Identities = 296/603 (50%), Positives = 437/603 (73%), Gaps = 3/603 (0%)

Query  1    MRLFLCEKPSQAKDIAAALGATRRGDGCWVGASATVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIA  LGAT+RG+G   G++ TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEANELVIATDADREGEMIARELVEHCRY  119
              + LP++P++WK++VK+ + +QF  ++RLL + +E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPAPFWAIDVKLLHENQAFIAQWRAPSDA  239
            ++G   VL+VGRVQTPTL +VV RDR I +FV+ P+  +   +  +   F ++W ++++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNQPLaqqaadamrhaasarLVKLRTERMREAAPLPFDLGTLQEICSKKLGLG  299
            CD++ RC++  +A Q  +  R++++A +++ + ER +++APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIITALGKTDPALAGLLPHLDPQ  359
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E + +++A+  TDPAL  +++ LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDAKVTAHHGIIPTAAVRGVERLIGKPRAVYTLIRARYLAQFLPNHEYDRTQAD  419
              SR WND K+TAHHGIIPT    ++ +L +  R VY L+R +YLAQFLP+ E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGQALRAVGKQIVEPGWKRAMPEALAPAKGREapapqplpalFQGCECAVADVILKD  479
            F+ +GQ +R+ G+ +V PGWK           +  + +  P     Q C+  V +   K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ--VQGAEQKV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLT  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KQGKALCATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQ  599
            ++ K+L +TP + +L+D +P ++++PG TA+WEQ LD V +G +SL++F+AKQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VSR  602
            V++
Sbjct  599  VAQ  601

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  494 bits (1861),  Expect = 8e-141, Method: Compositional matrix adjust.
 Identities = 294/603 (49%), Positives = 432/603 (72%), Gaps = 3/603 (0%)

Query  1    MRLFLCEKPSQAKDIAAALGATRRGDGCWVGANATVTWCIGHLLETAPPDAYDARY-KRW  59
            MRL LCEKPSQ++DIA  LGAT+RG+G   G+  TVTW  GHLLETA P+ Y+ +Y K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   VLEDLPIIPEKWKMLVKPRTASQFKAVKRLLGEAQELVIATDADREGEMIARELVEHCRY  119
              + LP++P++WK++VK+ + +QF  ++RLL + +E+VIATDADREGE+IAREL++ C++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  RGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGR  179
            +G + RLW+SALDDASIR ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  QSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPAPYWAIDVRLLHDNQAFIAQWRAPSDA  239
            ++G   VL+VGRVQTPTL +VV RDR I NFV+ PY  +   +  +   F ++W ++++ 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  240  CDDQDRCLNQPLaqqaaeamrsaasarLVKLRTERIREVAPLPFDLGTLQEICSKKLGLG  299
            CD++ RC++  +A Q  +  R +++A +++ + ER ++ APL+F L+TLQ+ CS+  G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  300  AQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIIAVLCKADPTLASLSPHLDPQ  359
            AQ  LDIAQ LYETHK+ TYPR+DCGYLP S + E + +++ +  +DP+L ++ + LD Q
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  360  RRSRAWNDGKVTAHHGIIPTAAVRGVERLTGKPRAVYTLIRARYLAQFLPSHEYDRTQAD  419
              SR WND K+TAHHGIIPT    ++ +L++  R VY L+R +YLAQFLP  E D T+A 
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  420  FDCAGHALRAVGKQIVEPGWKRAMPEALAPAKGREapapqplpalFQGCECTVAEVILKD  479
            F+ +G+ +R+ G+ +V PGWK           +  + +  P     Q C+   AE   K 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQ--KV  478

Query  480  LWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLT  539
            L T+PP P+ +G LI AM N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+L 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  540  KQGKALCAAPAAFSLIDAVPRAIADPGTTAIWEQALDMVQNGEMSLEEFVAKQAAWMSKQ  599
            ++ K+L ++P + +L+D +P ++++PG TA+WEQ LD V  G +SL++F+AKQ+ W+S+ 
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  600  VSR  602
            V++
Sbjct  599  VAQ  601

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  491 bits (1850),  Expect = 6e-140, Method: Compositional matrix adjust.
 Identities = 287/594 (49%), Positives = 438/594 (74%), Gaps = 3/594 (0%)

Query  1    MLGASRRGDGCWLGNGVTVTWCIGHLLETAPPDTYDAKY-KRWVLADLPIVPQKWKMLVK  59
             LGA++RG+G   G GVTVTW  GHLLETA P+ Y+ +Y K W    LP++PQ+WK++VK
Sbjct  18   FLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVK  77

Query  60   PKTASQFKAVKRLLGEAQELIIATDADREGEMIARELVEHCRYRGPIQRLWLSALDDASI  119
            + + +QF  ++RLL + +E++IATDADREGE+IAREL++ C+++G + RLW+SALDDASI
Sbjct  78   ADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASI  137

Query  120  RKALAALKPGAETFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPT  179
            R ALA L P++ T SLY +++GRSRADWLIGMN++RLFTLLGR++G   VL+VGRVQTPT
Sbjct  138  RSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPT  197

Query  180  LRLVVDRDRSIADFVPVAYWAIDVDLRHDAITFTAQWRAAEDACDDQGRCLNPQLardaa  239
            L +VV RDR I +FV+ +Y  +   +  +++ F ++W +A + CD++ RC+++ +A +  
Sbjct  198  LAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVV  257

Query  240  qamtqaasarLVKLRTERMREVAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETHKV  299
            Q   Q+++A +++ + ER ++ APL+F L+TLQ+ CS+  G+ AQ  LDIAQ LYETHK+
Sbjct  258  QLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKL  317

Query  300  ITYPRSDCGYLPLSQHSDAPKILAALGRADAAVNELMPHIDPQRRSRAWNDAKVSAHHGI  359
             TYPR+DCGYLPLS + + P++L+A+  +D+A++ +++ +D Q  SR WND K++AHHGI
Sbjct  318  TTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGI  377

Query  360  IPTGAGKDLGQLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKVVIE  419
            IPT    DL++L++ +R VY L+R +YLAQFLP+ E D T+A F+ +GQ +R+ G+V++ 
Sbjct  378  IPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVK  437

Query  420  PGWKRALPEALAPAKGREapapqalptlaqGRDYVVARVNLKDLWTQPPKPFTEGDLIKA  479
            PGWK  +     +  + +  +  +LP++  G+   V   + K L T+PP P+ +G LI A
Sbjct  438  PGWKSLFGK--MSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAA  495

Query  480  MKNVAKLVQDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLVKNGKALSATPAAFSLID  539
            M N A +V D+ LK+ LK+ +GIGTEATRAGII+ LL RG+LV++ K+L +TP + +L+D
Sbjct  496  MTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVD  555

Query  540  AVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQVARCNGMRMTI  593
             +P ++++PG TA+WEQ LD V +G +SL++F+AKQ+ W+S+ VA+  +  +T+
Sbjct  556  VLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTM  609

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  489 bits (1845),  Expect = 1e-139, Method: Compositional matrix adjust.
 Identities = 279/582 (48%), Positives = 423/582 (73%), Gaps = 3/582 (0%)

Query  34   VVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLR  93
            V++ LL +  ++VIATDADREGE+IARE++D C ++G + RLW+SAL+DASIR+AL+ L+
Sbjct  86   VINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLW  145

Query  94   PSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGLQAGYDGVLSVGRVQTPTLKLVVDRD  153
            PSS T ++YY++++RSRADWL+GMNL+RLFT+LG +AG + VLSVGRVQTPTL +VV RD
Sbjct  146  PSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRD  205

Query  154  REIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGCTDDAGRCLqqpiaqqaaqqiraass  213
            REI  F S P+  +  +++  G  F+++WVP+    D+  RC+Q  +A Q  Q  R +++
Sbjct  206  REIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPT  265

Query  214  aqVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDS  273
            A +++ + ER ++++PL F L+TLQ+ CS++ G+  Q  L+IAQ LYETHK TTYPR+D 
Sbjct  266  AAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDC  325

Query  274  GYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPAN  333
            GYLP SM  E+P VL +++ TDP+L+P+++ LD    SR WND K+TAHHGIIPT + ++
Sbjct  326  GYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGD  385

Query  334  LSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLA  393
            LS +S+ E  VY+L+R HYLAQFLP+ E+D T A ++ G Q + + G+ +   GW  +++
Sbjct  386  LSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFG  445

Query  394  EPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFV  453
                D++++T   +  LPA++ G  CQV  AE K L+T PP PY +G L+ +M   A FV
Sbjct  446  KMSEDDEDNTGETT--LPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFV  503

Query  454  TDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAAFTLIDAVPAAIAD  513
            TD+ LK+ LK+ +GIGTEATRA II  LL RG+LV+  ++++++  +  L+D +P+++++
Sbjct  504  TDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTN  563

Query  514  PGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAP  573
            PG TA+WEQ LD + AG+++LD F++KQ+ W+SQL+ Q  S +L+++ P +P+CP CG+ 
Sbjct  564  PGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGK  623

Query  574  TRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGASRPRSSG  615
            T QR GK+G FW+C +YP+CKG +  ++  + RG  R  S++
Sbjct  624  TLQRNGKSGLFWGCLKYPECKGIVN-NGNKGPRGRRRKPSPA  664

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  478 bits (1801),  Expect = 4e-136, Method: Compositional matrix adjust.
 Identities = 282/586 (49%), Positives = 424/586 (73%), Gaps = 4/586 (0%)

Query  1    MTVTWCIGHLLETAPPDAYDPRY-KRWVLADLPIVPERWKMLVKPKTASQFKAVKRLLGE  59
            +TVTW  GHLLETA P+ Y+ +Y K W    LP++P++WK++VK+ + +QF  ++RLL +
Sbjct  34   VTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQ  93

Query  60   CRELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGAETFNL  119
              E+VIATDADREGE+IAREL++ C+++G + RLW+SALDDASIR ALA L P++ T +L
Sbjct  94   VDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESL  153

Query  120  YHAALGRSRADWLIGMNMSRLFTLLGRQSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIP  179
            Y A++GRSRADWLIGMN++RLFTLLGR++G   VL+VGRVQTPTL +VV RDR I +F++
Sbjct  154  YYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVS  213

Query  180  VPFWAIDVQLLADGAAFTAQWQAPDDLCDDQGRCLDqaraqqaadamrnaasarLLKLKT  239
             P+  +   +  +G  F ++W ++ + CD++ RC++ + A Q  +  R++++A +++ + 
Sbjct  214  KPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQI  273

Query  240  ERQREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDCGYLPLSQL  299
            ER++++APL+F L+TLQ+ CS+  G+ AQ  LDIAQ LYETHKL TYPR+DCGYLPLS  
Sbjct  274  ERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMR  333

Query  300  GEARAIVAALTQADPTLAALQPHLDLSRRSRAWNDAKVGAHHGIVPTaaarglerlagrp  359
             E   +++A+  +DP+L ++ + LD    SR WND K+ AHHGI+PT  + +L +L++  
Sbjct  334  EEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAE  393

Query  360  raVYELIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKRVVEPGWKRAMPEALAPARG  419
            R VY+L+R +YLAQFLP+ E D T+A F+ +GQ +R+ G+ +V PGWK         + +
Sbjct  394  RNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKM---SED  450

Query  420  NREAHAPQSLPALQQGQDYAVGEITLKDQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQ  479
            + +  +  +LPA+Q GQ   V     K  QT+PP P+ +G LI AM N A +V D+ LK+
Sbjct  451  DEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKK  510

Query  480  KLKDTTGIGTEATRAGIIQGLLDRGYLVRQGKALAATPAAFSLIDAVPRPIADPGTTAIW  539
             LK+ +GIGTEATRAGII+ LL RG+LVR+ K+L +TP + +L+D +P  +++PG TA+W
Sbjct  511  VLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALW  570

Query  540  EQALDMVQSGEMPLEEFVAKQSAWMSKLVERCAGLRMTISGPPVAA  585
            EQ LD V +G ++L++F+AKQS W+S+LV +  +  +T+ +PP ++
Sbjct  571  EQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  476 bits (1796),  Expect = 1e-135, Method: Compositional matrix adjust.
 Identities = 309/659 (47%), Positives = 442/659 (68%), Gaps = 16/659 (2%)

Query  1    MRLFLCEKPSQAKDIASVLGC-KRGDGVFTGDGIAVTFCVGHVLQQAEPENYNPDFE-TW  58
            MRL LCEKPSQ++DIA  LG  +RG+G + G G++VT   GH+L+ AEPE Y  ++   W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   NIVDLPIIPTVWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYVNY  118
                LP++P  WK++V + +KAQFA++++ L +  EV+IATDADREGEVIARE+L+Y ++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  KGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLCTLLSR  178
            +G + RLW+SALDDASI+ ALA L+P+  T  LY AG+GRSR+DWLIGMN+TRL TLL+R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  EYGYQGAFSVGRVQTPTLRLVVDRDRQVEQFEPQSYYD-ITGLFNATIPFKAKWQVPDNL  237
            E G    +SVGRVQTPTL +VV RDR++++F +++Y++ I+ +    + F +KW  + + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  238  GDEQGRCLQVTTVDHVLSQCRDQP-GTVTQFDTKRQKSKHPPLFFLGSLQKAMSAKFGYG  296
             DE+ RC+Q     +V+  CR+ P +++ + +  R+K   P  F L++LQ+A S   G  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  297  AKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKKEVGSILDKLKVV-PTFAAWCSVADVN  355
            A+ VLDIAQ LYE  K+TTYPRTDC YLPLS + E+  +L  +    P++ +  +  D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  356  ETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAEDDATTIE  415
              S  WNDKKITAHHGIIP   T  L  +++ E N+Y+ +  +YLAQF P  E D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  416  LMVGSQSFKATGKVERVKGWRLVTGKDSEDETADDS-SNLPLLSIGQTLTAQFQREDKR-  473
            + +G+Q F++ G+V    GW+ + GK SED+  + + + LP +  GQ    Q Q  +++ 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VCQVQGAEQKV  478

Query  474  --TKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKARGFVT  531
              TKPP+ + +GTLI AM+N A F +D+ LK +LKE +GIGTEATRA IIDTL  RGF+ 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  532  VTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTFITQL  591
               K L S+  GR+L+D LP+ LT P++TALWEQ LDE+A G  SLDDFMA+QS  ++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  592  VSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQLSGKSGKFWVCEDKEQC-GLLLNDERG  649
            V+  +    T++ P     + PCPVC     Q +GKSG FW C    +C G++ N+++G
Sbjct  599  VAQGRSQPLTMQAPP----SPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKG  653

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  473 bits (1784),  Expect = 1e-134, Method: Compositional matrix adjust.
 Identities = 308/659 (47%), Positives = 442/659 (68%), Gaps = 16/659 (2%)

Query  1    MRLFLCEKPSQAKDIASVLGC-KRGDGVFTGDGIAVTFCVGHVLQQAEPENYNPDFE-TW  58
            MRL LCEKPSQ++DIA  LG  +RG+G + G G++VT   GH+L+ AEPE Y  ++   W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   NIVDLPIIPTAWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYVNY  118
                LP++P  WK++V + +KAQFA++++ L +  EV+IATDADREGEVIARE+L+Y ++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  KGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLCTLLSR  178
            +G + RLW+SALDDASI+ ALA L+P+  T  LY AG+GRSR+DWLIGMN+TRL TLL+R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  EYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYD-ITGLFNATIPFKAKWQVPDNL  237
            E G    +SVGRVQTPTL +VV RD ++++F +++Y++ I+ +    + F +KW  + + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  238  GDEQGRCLQVTTVDHVLSQCRDQP-GTVTQFDTKRQKSKHPPLFFLGSLQKAMSAKFGYG  296
             DE+ RC+Q     +V+  CR+ P +++ + +  R+K   P  F L++LQ+A S   G  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  297  AKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVV-PAFAAWCSAADVN  355
            A+ VLDIAQ LYE  K+TTYPRTDC YLPLS +EE+  +L  +    PA+ +  ++ D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  356  ETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAEDDATTIE  415
              S  WNDKKITAHHGIIP   T  L  +++ E N+Y+ +  +YLAQF P  E D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  416  LMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDS-ANLPLLSIGQTLTAQFQREDKR-  473
            + +G+Q  ++ G+V    GW+ + GK SED+  + + + LP +  GQ    Q Q  +++ 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VCQVQGAEQKV  478

Query  474  --TKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKARGFVT  531
              TKPP+ + +GTLI AM+N A F +D+ LK +LKE +GIGTEATRA IIDTL  RGF+ 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  532  VTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTFITQL  591
               K L S+  GR+L+D LP+ LT P++TALWEQ LDE+A G  SLDDFMA+QS  ++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  592  VSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQLSGKNGKFWVCEDKEQC-GLLLNDERG  649
            V+  +    T++ P     + PCPVC     Q +GK+G FW C    +C G++ N+++G
Sbjct  599  VAQGRSQPLTMQAPP----SPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKG  653

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  472 bits (1780),  Expect = 2e-134, Method: Compositional matrix adjust.
 Identities = 308/659 (47%), Positives = 442/659 (68%), Gaps = 16/659 (2%)

Query  1    MRLFLCEKPSQAKDIASVLGC-KRGDGVFTGDGIAVTFCVGHVLQQAEPENYNPDFE-TW  58
            MRL LCEKPSQ++DIA  LG  +RG+G + G G++VT   GH+L+ AEPE Y  ++   W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  59   NIVDLPIIPTVWKMLVSPKTKAQFAIVKKQLAKATEVIIATDADREGEVIAREVLEYVNY  118
                LP++P  WK++V + +KAQFA++++ L +  EV+IATDADREGEVIARE+L+Y ++
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  119  KGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGDWLIGMNMTRLCTLLSR  178
            +G + RLW+SALDDASI+ ALA L+P+  T  LY AG+GRSR+DWLIGMN+TRL TLL+R
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  179  EYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYD-ITGLFNATIPFKAKWQVPDNL  237
            E G    +SVGRVQTPTL +VV RD ++++F +++Y++ I+ +    + F +KW  + + 
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  238  GDEQGRCLQVTTVDHVLSQCRDQP-GTVTQFDTKRQKSKHPPLFFLGSLQKAMSAKFGYG  296
             DE+ RC+Q     +V+  CR+ P +++ + +  R+K   P  F L++LQ+A S   G  
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  297  AKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVV-PAFAAWCSAADVN  355
            A+ VLDIAQ LYE  K+TTYPRTDC YLPLS +EE+  +L  +    PA+ +  ++ D +
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  356  ETSACWNDKKITAHHGIIPLPVTPKLHEMNEKELNLYHAIVQRYLAQFYPVAEDDATTIE  415
              S  WNDKKITAHHGIIP   T  L  +++ E N+Y+ +  +YLAQF P  E D T   
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  416  LMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDS-ANLPLLSIGQTLTAQFQREDKR-  473
            + +G+Q  ++ G+V    GW+ + GK SED+  + + + LP +  GQ    Q Q  +++ 
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VCQVQGAEQKV  478

Query  474  --TKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRANIIDTLKARGFVT  531
              TKPP+ + +GTLI AM+N A F +D+ LK +LKE +GIGTEATRA IIDTL  RGF+ 
Sbjct  479  LQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLV  538

Query  532  VTGKQLISSEAGRSLIDALPDVLTRPAMTALWEQALDEIALGNGSLDDFMARQSTFITQL  591
               K L S+  GR+L+D LP+ LT P++TALWEQ LDE+A G  SLDDFMA+QS  ++QL
Sbjct  539  REKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQL  598

Query  592  VSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQLSGKNGKFWVCEDKEQC-GLLLNDERG  649
            V+  +    T++ P     + PCPVC     Q +GK+G FW C    +C G++ N+++G
Sbjct  599  VAQGRSQPLTMQAPP----SPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKG  653

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  463 bits (1744),  Expect = 2e-131, Method: Compositional matrix adjust.
 Identities = 291/606 (49%), Positives = 413/606 (69%), Gaps = 4/606 (0%)

Query  1    MRVYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSL-KRW  59
            MR+ LCEKPSQ+RDIA  LG   ++ + +  ++  VTWA GHLLE A P+ Y++   K W
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW  60

Query  60   ALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVGF  119
                LP+ P QWK+ VK+ AK QF  I  LLK+  EVVIATDADREGE+IAREL+ +  F
Sbjct  61   RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF  120

Query  120  KGKVQRLWlsaldaasvkkalaalkpsaETAGLYQSALGRSRADWLVGMNLTRAFTLAGC  179
            +G+V RLW+SALD AS++ ALA L PS+ T +LY +++GRSRADWL+GMNLTR FTL G 
Sbjct  121  QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR  180

Query  180  SQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFE-AGQSFSTKWKVPEGA  238
              G   V SVGRVQTPTL++VV RDR+I++F + PYFE+++     G  F++KW  +   
Sbjct  181  EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY  240

Query  239  GDDAGRCVDQSIVDAVASKI-TGKTGTVSQYETKRISENPPLPFSLSTLQKTCSAKFGLG  297
             D+  RC++ ++   V        T+++ + +  R  +++PL+FSLSTLQ++CS   G+ 
Sbjct  241  CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP  300

Query  298  AQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQGIVDLLDFS  357
            AQ VLDIAQ LYETHK TTYPR+DC +LP    +E + +++A+  +D  +Q +V  LD  
Sbjct  301  AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ  360

Query  358  RKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNYEYDRTQIG  417
              S  WN KKITAHH+IIPT+   ++  +SD ER VY+L+R +YLAQFLP+ E D T+  
Sbjct  361  FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT  420

Query  418  ISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAK  477
            ++I G+LF+T G++    GW+ LFGK    D++  +E  TLPA+  GQ   +  +E    
Sbjct  421  FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET-TLPAMQAGQVCQVQGAEQKVL  479

Query  478  QTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANLIERGFITK  537
            QTKPP+ Y +GTLI AM   +  +TD+ LK +LKEN+GIGTEATRAGII  L+ RGF+ +
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  538  KGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADVVKFITAII  597
              K + S+ +GR+L+D LP+++ +P+LTALWEQ L+E+A G+  L +F A   + ++ ++
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLV  599

Query  598  DQIKKQ  603
             Q + Q
Sbjct  600  AQGRSQ  605

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1739),  Expect = 4e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GFL++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCVNKAYAEQVASQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RC++ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFAASGKTPAKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGA  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.3 bits (133),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1739),  Expect = 4e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GFL++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCVNKAYAEQVASQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RC++ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGA  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.3 bits (133),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1739),  Expect = 4e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GFL++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCVNKAYAEQVASQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RC++ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGA  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.3 bits (133),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1739),  Expect = 4e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GFL++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCVNKAYAEQVASQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RC++ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGA  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVASGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.3 bits (133),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1739),  Expect = 4e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFIHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GF+++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPDAWRYNVRKSALKQYKIVEGLVKKASTIYISTDFDREGEAIARSLLDQFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKETVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCINKAYAEQVSSQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RCI+ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDSKVTAHHAIIPTPARTDISAMSEIELNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFAASGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGTELMNKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGT  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVATGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVDQLKVAAPVLTKEGSAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.6 bits (134),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  461 bits (1737),  Expect = 6e-131, Method: Compositional matrix adjust.
 Identities = 277/680 (41%), Positives = 445/680 (66%), Gaps = 26/680 (3%)

Query  1    MDLYICEKPSQAKDLAGVMKASQRGDGFIHDGGNRVITWAFGHLLELYMPDDYDERY-KS  59
            M L +CEKPSQ++D+A  + A+QRG+GF+++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLETLPIAPDAWRYNVRKSALKQYKIVEGLVKKASTIYISTDFDREGEAIARSLLDQFR  119
            W  + LP+ P+ W+  V+  A  Q+ +++ L+K+   + I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPIRRVCLTALDESSIKKALNNVKDGKETVSLYYAALARQRADWLVGMNVSRLYTVLA  179
            + G + R+ ++ALD++SI+ AL ++  +  T SLYYA+++R RADWL+GMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDREI  F + PY  +   ++V+   F+++W+P+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDEQGRCINKAYAEQVSSQ-VNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGY  298
              DE+ RCI+ + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQALYETHKATTYPRTDSRYLPESQKENIPDILQALILSDQNVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+IP++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDSKVTAHHAIIPTPARTDISAMSEIELNLYDAIRRFYIAQFYSEFEFTKTSI  418
            +  +R+ ND K+TAHH+IIPT    D+S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQCGRHLFAASGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF+  SE    + GE T ++++  ++ +V  +E  +L
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  479  NGTELMNKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGT  538
            +        T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  480  Q--------TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVATGSGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ VA+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  STWICQMVDQLKVAAPVLTKEGSAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ  658
            S W+ Q+V Q             + ++++    PPS  C  CGG   + +GK+G+FWGC 
Sbjct  592  SQWVSQLVAQ-------------GRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCL  638

Query  659  N-EACKKTFPD-NRGKPEKR  676
            +   CK    + N+G   +R
Sbjct  639  KYPECKGIVNNGNKGPRGRR  658


 Score = 40.6 bits (134),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 20/55 (37%), Positives = 31/55 (57%), Gaps = 7/55 (12%)

Query  667  PDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTM  721
            ++ R++P   + A   P CP CG+    R+GK+      + FWGC  YP+CKG +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  451 bits (1699),  Expect = 6e-128, Method: Compositional matrix adjust.
 Identities = 282/681 (42%), Positives = 439/681 (65%), Gaps = 27/681 (3%)

Query  1    MDLYICEKPSQAKDLAGVLKLTQRGDGFIHDGGKRVITWAFGHLLEMYMPDDYDEKY-KS  59
            M L +CEKPSQ++D+A  L  TQRG+GF+++ G   +TWA GHLLE   P+ Y+E+Y K+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGV-TVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WSLDSLPIAPESWQSKVRQKSAKQYKIIEGLVKKASTVYISTDYDREGEAIARSLLDRFR  119
            W  D LP+ P+ W+  V+  +  Q+ +I+ L+K+   V I+TD DREGE IAR LLD  +
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  YSGPVRRVCLTALDESSIRKALSNIKDGQDTVPLYYAALGRQRADWLIGMNVSRLYTVLA  179
            + G V R+ ++ALD++SIR AL+++  +  T +LYYA++GR RADWLIGMN++RL+T+L+
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RQVGFESTLHVGRVITPTVALVCQRDRDIAGFTPSPYWVLGVNVAVQNGQFLAQWVPPEE  239
            R+ G+ + L VGRV TPT+A+V +RDR+I  F + PY  +   +AV+   F ++WVP+ +
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  CSDDQGRCTNKAYAEQVASQ-INGAQAVISKAETKPGKESAPLPFDLTALQQYGSKRWGY  298
              D++ RC + + A QV     + + A I + +    K+SAPL+F L++LQQ  S++WG 
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  299  TAQQVLDAAQSLYETHKATTYPRTDSRYLPESQKENISDILQALILSDQRVSGLVAGADP  358
             AQ VLD AQ LYETHK TTYPRTD  YLP S +E+I+++L A++ +D  +  +VA+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  359  HRKARVFNDSKVSAHHAIIPTPARTNISAMSEIELNLYDAIRRFYIAQFYSEFEFSKTVI  418
            +  +R+ ND K++AHH+IIPT    ++S +S+ E N+Y+ +R  Y+AQF ++ E+  T  
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  419  EVQSGRHLFAASGKTPTKQGWKVLFTSDSESDPKEEGEDVDALIEQEKLPRVSQGEPALL  478
              + G +LF + G+   K GWK LF   SE D  + GE          LP +  G+   +
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET--------TLPAMQAGQVCQV  471

Query  479  KGADLANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGA  538
            +GA+     T+P++ + ++TL+AAM N A FVT+  +K++LK+ AG+GT ATRA+II+  
Sbjct  472  QGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  539  VDKGYFKRQKKVLIATEKAHALIAVLPPAIKSPGMTAAWEQELEKIATGAGNMSVFMKQI  598
            + +G++ R+KK L +T  ++ L+ VLP ++ +PG+TA WEQ L+ +A+G  ++  FM + 
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  599  SSWICQMVEQLKTAAPALTQDGGAMVKAFAGAKPQLHVCFNCGGETLIRIKGKNGFFWGC  658
            S W+ Q+V Q ++ + ++               P    C  CGG TL R +GK+G+FWGC
Sbjct  592  SQWVSQLVAQGRSQPLTMQA-------------PPSPPCPVCGGKTLQR-NGKSGLFWGC  637

Query  659  -KNEACKKTFPD-NRGKPEKR  677
             K   CK    + N+G   +R
Sbjct  638  LKYPECKGIVNNGNKGPRGRR  658


 Score = 37.4 bits (122),  Expect = 0.003, Method: Compositional matrix adjust.
 Identities = 17/55 (31%), Positives = 30/55 (55%), Gaps = 7/55 (12%)

Query  668  PDNRGKPEKRIATEDCPACPDCASPMRLRKGKAPGKVRATKFWGCTGYPDCKTTM  722
            ++ R++P   + +   P+CP C++    R+GK+        FWGC  YP+CK  +
Sbjct  600  AQGRSQPLT-MQAPPSPPCPVCGGKTLQRNGKS------GLFWGCLKYPECKGIV  647

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  433 bits (1629),  Expect = 2e-122, Method: Compositional matrix adjust.
 Identities = 271/617 (44%), Positives = 429/617 (70%), Gaps = 19/617 (3%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHKKGEGFIETAQGDVVTWCIGHLLEQAEPDAYDAAY-K  59
            MRL + EKPS GR IA  L   ++ GEGF++ + G  VTW  GHLLE AEP+ Y+  Y K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRMESLPIVPAQWQLVAKPKTKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFL  119
             WR + LP++P QW+LV K+ +K+Q++VI+RLLKQ D VV A D+DREG+++  E++D+ 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYT  179
             + + R V+R  +S L+ +++R AL  L+ +    +L  ++++RSRADWL G+N+TR +T
Sbjct  119  KF-QGR-VFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFT  176

Query  180  LLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNEHFSAKWL  239
            LLGR +G +++LSVGRVQTP L++VV+RD EI+ FV+KP+FEV+A +  +G   F++KW+
Sbjct  177  LLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV-LFPSKWV  235

Query  240  PSEA-CLPWQDEEGRVLNRALAAKVVERI-QGQPALVEEVEEQARKQAAPLPYNLSSLQI  297
            P+   C    DEE R ++ ++AA+VV+   Q   A + + + + +KQ+APL+++LS+LQ 
Sbjct  236  PAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  298  DAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALA  357
              +++ GM A+ VLD+ Q LYE HKL TYPR+D   LP    +   QV  A+ +T PAL 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  358  KAVSEADGKIRSKAWNDSKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPP  417
              V+  D ++ S+ WND K+ AHH+IIPT   G+ + L+  E ++Y L+  +YL QF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  418  FEYNDSKVLLRIAGGLFQAKARRILKAGWKALLG-VEEDDEEEAG--TLPALRKGEQLLC  474
             E + +   + I+G LF++++  ++K+GWK+L+G + EDDE+++G  TLPA++ G+  +C
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VC  469

Query  475  ERGELQEKM--TQPPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIID  532
            +    ++K+  T+PP ++ D+TL+AAMT  A +V D+ ++K L+E  G+GTEATRAGIID
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  533  LLFKRRFLVRQGKSIKATPTGRALIQALPATATTPDMTALWEQHLGRIAERQTSYQQFMG  592
             L+KR FLVR+ K++K+TP GR L++ LP+T T P++TALWEQ L+ +A  + S ++FM+
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  593  PLTEQLNGLIDGARQDS  609
              ++ ++ L+  +R ++
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  432 bits (1628),  Expect = 2e-122, Method: Compositional matrix adjust.
 Identities = 275/665 (42%), Positives = 422/665 (64%), Gaps = 22/665 (3%)

Query  1    MKLFIAEKPSVAKAIAAELGVTGKGDGYIECGGDKVTWCFGHMLEQAGPDEYTPDDVPTN  60
            M+L + EKPS ++ IA  LG T +G+G+++  G  VTW  GH+LE A P+ Y        
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   DKGRKIWRVDELPIIPDEWILRPKDDAKKQVRVIGGLLKSASQIVNAGDPDREGQLLVDE  120
            ++  K WR D LP++P++W L  K DAK Q  VI  LLK   ++V A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  LLEHFNNKKPVIRYWSNAIDSVSVKRALANMKDNQEYHGFADAAEGRGKADWLIGMNLSR  180
            LL+  + +  V+R W +A+D  S++ ALA++  +   +++  A+ GR++ADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVTRDREIESFKAVPFHTIRAEIQHPNGAFWAS  240
             +TL ++ +G   +L+VGRVQTPTLA+VV RDREI++F + P+  + A +      F + 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDAEGRLVDTAVANALVE-SLTGKPGSISEYKQEAKKQNHPLTFSLSDMTA  299
            W +  +    D E R ++++VA  +V+       ++I + + E KKQ+ PL+FSLS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASKRFGYSAEDVLKTCQSLYETHKLTTYPRTDCAYLPESQFADAPDVLASVKAVNPSLA  359
              S++ G +A+ VL   Q LYETHKLTTYPRTDC+YLP S   + P+VL++V + +P+L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  SIVDGADTSIRSRTWNDKKVSAHHGIIPTMHKGDLNKLNDKERNIYDLVVRAYLAQFYPV  419
            ++V + DT + SR WNDKK++AHHGIIPT H GDL+KL+D ERN+Y+LV   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEFMSTTVTVDVEGETFSAKGKVVTKSGWHDVYLDNsdeddsdqddesqsLPKMGQGDAI  479
             E+  T  T ++ G+ F ++G+V+ K+GW  ++      +D +++    +LP M  G+  
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLF--GKMSEDDEDNTGETTLPAMQAGQVC  469

Query  480  TCGQAARRDAKTKPPARFTEGTLITAMVNIHRFVTDPQHKKMLREGDGIGTEATRASIIS  539
                A ++  +TKPPA + +GTLI+AM N   FVTD+  KK+L+E  GIGTEATRA+II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  540  ELKRRNYLETKGKQIISTTLGRSMIDALPEVVKSPVLTALYERMLQSVESGKADLAAFIT  599
             L +R +L    K + ST LGR+++D LP  + +P LTAL E+ML+ V +G+  L  F++
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  600  KQEAFIREQVAKANDGAVAIAGGKEAAPVSDVFKCMSCGAGLSRRPLPKKKGHFWWGCSN  659
            KQ   + + VA++   ++++ +   ++       C  CG+   +R    K G F WGC +
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPP-------CPVCGGKTLQR--NGKSGLF-WGCLK  639

Query  660  YPTCK  664
            YP CK
Sbjct  640  YPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  430 bits (1620),  Expect = 1e-121, Method: Compositional matrix adjust.
 Identities = 273/665 (42%), Positives = 421/665 (64%), Gaps = 22/665 (3%)

Query  1    MKLFIAEKPSVAKAIAAELGVTGKGDGYIECGGDKVTWCFGHMLEQAGPDEYTPDDVPTN  60
            M+L + EKPS ++ IA  LG T +G+G+++  G  VTW  GH+LE A P+ Y        
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   DKGRKIWRVDELPIIPDEWILRPKDDAKKQVRVIGGLLKSASQIVNAGDPDREGQLLVDE  120
            ++  K WR D LP++P++W L  K DAK Q  VI  LLK   ++V A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  LLEHFNNKKPVIRYWSNAIDSVSVKRALANMKDNKEYHGFANAAEGRGKADWLIGMNLSR  180
            LL+  + +  V+R W +A+D  S++ ALA++  +   +++  A+ GR++ADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVTRDREIESFKAVPFHTIRAEIQHPNGAFWAS  240
             +TL ++ +G   +L+VGRVQTPTLA+VV RDREI++F + P+  + A +      F + 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDAEGRLVDTAVANALVE-SLTGKPGSISEYKQEAKKQNHPLTFSLSDMTA  299
            W +  +    D E R ++++VA  +V+       ++I + + E KKQ+ PL+FSLS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASKRFGYSAEDALKTCQSLYETHKLTTYPRTDCAYLPESQFADAPDVLAAVKAVNPGLA  359
              S++ G +A+  L   Q LYETHKLTTYPRTDC+YLP S   + P+VL+AV + +P+L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  SIVDGADTSIRSRTWNDKKVSAHHGIIPTMHKGDLNKLNDKERNIYDLVVRAYLAQFYPI  419
            ++V + DT + SR WNDKK++AHHGIIPT H GDL+KL+D ERN+Y+LV   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEFMSTTVAVDVEGERFSAKGKVVTKSGWHDVYLDNsdeddsdqddesqsLPRMGQGDAV  479
             E+  T  + ++ G+ F ++G+V+ K+GW  ++      +D +++    +LP M  G+  
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLF--GKMSEDDEDNTGETTLPAMQAGQVC  469

Query  480  TCGQAARRDAKTKPPARFTEGTLITAMVNIHRFVTEPEHKKMLREGDGIGTEATRASIIS  539
                A ++  +TKPPA + +GTLI+AM N   FVT++  KK+L+E  GIGTEATRA+II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  540  ELKRREYLETKGKQIISTTLGRSMIDALPEVVKSPVLTSLYERMLQSVESGKADLAAFIA  599
             L +R +L    K + ST LGR+++D LP  + +P LT+L E+ML+ V +G+  L  F+A
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  600  KQEAFIRDQVAKANDGAVAIAGGKEAAPVSDVFKCMSCGAGLSRRPLPKKKGHFWWGCSN  659
            KQ   + + VA++   ++++ +   ++       C  CG+   +R    K G F WGC +
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPP-------CPVCGGKTLQR--NGKSGLF-WGCLK  639

Query  660  YPTCK  664
            YP CK
Sbjct  640  YPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  429 bits (1617),  Expect = 2e-121, Method: Compositional matrix adjust.
 Identities = 276/665 (42%), Positives = 421/665 (64%), Gaps = 22/665 (3%)

Query  1    MRLFIAEKPSVAKAIAAELGVTGKGDGYIECGSDKVTWCFGHMLEQAGPDEYTPDDVPTN  60
            MRL + EKPS ++ IA  LG T +G+G+++  +  VTW  GH+LE A P+ Y        
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   DKGRKIWRVDELPIIPDEWILRPKDDAKKQVRVIGGLLKSASQVVNAGDPDREGQLLVDE  120
            ++  K WR D LP++P++W L  K DAK Q  VI  LLK   +VV A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  LLEHFNNTKPVIRYWSNAIDSVSVKRALASMKDNQEYHGFADAAEGRGKADWLIGMNLSR  180
            LL+  +    V+R W +A+D  S++ ALA +  +   +++  A+ GR++ADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVTRDREIESFKAVPFHTIRAEIQHPNGAFWAS  240
             +TL ++ +G   +L+VGRVQTPTLA+VV RDREI++F + P+  + A +      F + 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDAEGRLVDTAVANALVE-SLTGKPGSISEYKQEAKKQNHPLTFSLSDMTA  299
            W +  +    D E R ++++VA  +V+       ++I + + E KKQ+ PL+FSLS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASKRFGYSAEDVLKTCQSLYETHKLTTYPRTDCAYLPESQFADAPDVLAAVKAVNPALA  359
              S++ G +A+ VL   Q LYETHKLTTYPRTDC+YLP S   + P+VL+AV + +PAL 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  SIVDGADTSIRSRTWNDKKVSAHHGIIPTMHKGDLNKLNDKERNIYDLVVRAYLAQFYPI  419
            ++V + DT + SR WNDKK++AHHGIIPT H GDL+KL+D ERN+Y+LV   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEFMSTTVAVDVEGETFSAKGKVVTKSGWHDVYLdnsdedegdqddesqsLPKMGQGDAI  479
             E+  T  + ++ G+ F ++G+V+ K+GW  ++      ++++++    +LP M  G+  
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLF--GKMSEDDEDNTGETTLPAMQAGQVC  469

Query  480  TCGQAARRDAKTKPPARFTEGTLITAMVNIHRFVTDPQHKKMLREGDGIGTEATRASIIS  539
                A ++  +TKPPA + +GTLI+AM N   FVTD+  KK+L+E  GIGTEATRA+II 
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  540  ELKRREYLETKGKQIISTTLGRSMIDALPEVVKSPVLTALYERMLQSVESGKTELAAFIT  599
             L +R +L    K + ST LGR+++D LP  + +P LTAL E+ML+ V +G+  L  F++
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  600  KQEAFIRDQVAKANDGAVSIAGGKEAAPVSDVFKCMSCGAGLSRRPLPKKKGHFWWGCSN  659
            KQ   + + VA++   ++++ +   ++       C  CG+   +R    K G F WGC +
Sbjct  590  KQSQWVSQLVAQGRSQPLTMQAPPSPP-------CPVCGGKTLQR--NGKSGLF-WGCLK  639

Query  660  YPTCK  664
            YP CK
Sbjct  640  YPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  422 bits (1588),  Expect = 3e-119, Method: Compositional matrix adjust.
 Identities = 284/671 (43%), Positives = 421/671 (63%), Gaps = 33/671 (4%)

Query  1    MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG  60
            MRL + EKPS ++ IA  LGAT +G+GF++     VTW  GH+LE A+P+ Y       G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            +   K WR D LP++P+ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFRNSKPVRRFWVSAQDSVSVKRGLAAL-----KENTTYAGWADAARGRQRADWLIG  175
            +L+  +    V R+W+SA D  S++ +LA L      E+  YAG      GR RADWLIG
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAG-----VGRSRADWLIG  168

Query  176  MNLSRAYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGG  235
            MNL+R +TL ++ +G   +L+VGRVQTPTLA+VV RDREI+ F + PY  + A +   G 
Sbjct  169  MNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV  228

Query  236  SFAAAWKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIAAYKQEAKKQNQPLAFAL  294
             F++ W +  +    D E R ++++VA  +V   +  P ++I   + E KKQ+ PLAF+L
Sbjct  229  LFPSKWVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSL  286

Query  295  SDITALASAKFGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAIKHV  354
            S +    S   G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL A+   
Sbjct  287  STLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGT  346

Query  355  NPELAGLVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAALSERERNIYDLIVRAYLA  414
            +P L  +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLA
Sbjct  347  DPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLA  406

Query  415  QFYPLHEYMQTTVGVEIAGENFAASGKVVTRNGWRDVYSQAdeegekdedddSGTQALPS  474
            QF P  E   T    +I+G+ F + G+V+ + GW+ ++++       D++D++G  +LP+
Sbjct  407  QFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGK----MSEDDEDNTGETTLPA  462

Query  475  MAQGDAVTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSA  534
            M  G+     +A +K  +TKPPA + +GTLI AM N   FV+DA  KK+L+E  GIGT A
Sbjct  463  MQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  535  TRASIISELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTA  594
            TRA+II  L +R FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  595  ALDAFITKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQF  654
            +LD F++KQ   + + VA++ S ++T+    +A+P ++   C  CG+   +R + K G F
Sbjct  583  SLDDFMAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNG-KSGLF  634

Query  655  WWGCSNFPTCK  665
             WGC ++P CK
Sbjct  635  -WGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  422 bits (1588),  Expect = 3e-119, Method: Compositional matrix adjust.
 Identities = 284/671 (43%), Positives = 421/671 (63%), Gaps = 33/671 (4%)

Query  1    MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG  60
            MRL + EKPS ++ IA  LGAT +G+GF++     VTW  GH+LE A+P+ Y       G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            +   K WR D LP++P+ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFRNSKPVRRFWVSAQDSVSVKRGLAAL-----KENTTYAGWADAARGRQRADWLIG  175
            +L+  +    V R+W+SA D  S++ +LA L      E+  YAG      GR RADWLIG
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAG-----VGRSRADWLIG  168

Query  176  MNLSRAYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGG  235
            MNL+R +TL ++ +G   +L+VGRVQTPTLA+VV RDREI+ F + PY  + A +   G 
Sbjct  169  MNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV  228

Query  236  SFAAAWKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIAAYKQEAKKQNQPLAFAL  294
             F++ W +  +    D E R ++++VA  +V   +  P ++I   + E KKQ+ PLAF+L
Sbjct  229  LFPSKWVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSL  286

Query  295  SDITALASAKFGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAIKHV  354
            S +    S   G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL A+   
Sbjct  287  STLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGT  346

Query  355  NPELAGLVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAALSERERNIYDLIVRAYLA  414
            +P L  +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLA
Sbjct  347  DPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLA  406

Query  415  QFYPLHEYMQTTVGVEIAGENFAASGKVVTRNGWRDVYSQAdeegekdedddSGTQALPS  474
            QF P  E   T    +I+G+ F + G+V+ + GW+ ++++       D++D++G  +LP+
Sbjct  407  QFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGK----MSEDDEDNTGETTLPA  462

Query  475  MAQGDAVTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSA  534
            M  G+     +A +K  +TKPPA + +GTLI AM N   FV+DA  KK+L+E  GIGT A
Sbjct  463  MQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  535  TRASIISELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTA  594
            TRA+II  L +R FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  595  ALDAFITKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQF  654
            +LD F++KQ   + + VA++ S ++T+    +A+P ++   C  CG+   +R + K G F
Sbjct  583  SLDDFMAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNG-KSGLF  634

Query  655  WWGCSNFPTCK  665
             WGC ++P CK
Sbjct  635  -WGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  422 bits (1588),  Expect = 3e-119, Method: Compositional matrix adjust.
 Identities = 284/671 (43%), Positives = 421/671 (63%), Gaps = 33/671 (4%)

Query  1    MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG  60
            MRL + EKPS ++ IA  LGAT +G+GF++     VTW  GH+LE A+P+ Y       G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            +   K WR D LP++P+ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFRNSKPVRRFWVSAQDSVSVKRGLAAL-----KENTTYAGWADAARGRQRADWLIG  175
            +L+  +    V R+W+SA D  S++ +LA L      E+  YAG      GR RADWLIG
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAG-----VGRSRADWLIG  168

Query  176  MNLSRAYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGG  235
            MNL+R +TL ++ +G   +L+VGRVQTPTLA+VV RDREI+ F + PY  + A +   G 
Sbjct  169  MNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV  228

Query  236  SFAAAWKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIAAYKQEAKKQNQPLAFAL  294
             F++ W +  +    D E R ++++VA  +V   +  P ++I   + E KKQ+ PLAF+L
Sbjct  229  LFPSKWVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSL  286

Query  295  SDITALASAKFGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAIKHV  354
            S +    S   G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL A+   
Sbjct  287  STLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGT  346

Query  355  NPELAGLVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAALSERERNIYDLIVRAYLA  414
            +P L  +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLA
Sbjct  347  DPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLA  406

Query  415  QFYPLHEYMQTTVGVEIAGENFAASGKVVTRNGWRDVYSQAdeegekdedddSGTQALPS  474
            QF P  E   T    +I+G+ F + G+V+ + GW+ ++++       D++D++G  +LP+
Sbjct  407  QFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGK----MSEDDEDNTGETTLPA  462

Query  475  MAQGDAVTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSA  534
            M  G+     +A +K  +TKPPA + +GTLI AM N   FV+DA  KK+L+E  GIGT A
Sbjct  463  MQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  535  TRASIISELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTA  594
            TRA+II  L +R FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  595  ALDAFITKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQF  654
            +LD F++KQ   + + VA++ S ++T+    +A+P ++   C  CG+   +R + K G F
Sbjct  583  SLDDFMAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNG-KSGLF  634

Query  655  WWGCSNFPTCK  665
             WGC ++P CK
Sbjct  635  -WGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  419 bits (1579),  Expect = 2e-118, Method: Compositional matrix adjust.
 Identities = 266/617 (44%), Positives = 424/617 (69%), Gaps = 18/617 (2%)

Query  1    MRLFIAEKPTLGRAIADALPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAF-K  59
            MRL + EKP+ GR IA  L   ++ G+GF++ + G  VTW  GHLLE AEP+ Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRMEHLPIIPAQWQLVAKPKTKTQLTVIKRLIKQADCVVNAGDPDREGQLLVDEVIDFL  119
             WR + LP++P QW+LV K+ +K+Q++VI+RL+KQ D VV A D+DREG+++  E++D+ 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYPKTKPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYT  179
             +     V R  +S L+ +++R AL  L+ +    +L  ++++RSRADWL G+N+TR +T
Sbjct  119  KFQG--RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFT  176

Query  180  LLGRKAGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLLTEGNERFTAKWL  239
            LLGR AG +++LSVGRVQTP L++VV+RD EI+ FV+KP++EV+A +  +G   F +KW+
Sbjct  177  LLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV-LFPSKWV  235

Query  240  PSEA-CLPWQDEEGRVLNRALADKVVSRINGQP-AQVESVEEQARKQAAPLPYNLSSLQI  297
            P+   C    DEE R ++ ++A +VV      P A + + + + +KQ+APL+++LS+LQ 
Sbjct  236  PAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  298  DAAKRFGMDAKRVLDICQSLYERHKLITYPRSDSRYLPTDHFKRAEQVRGaiaatapala  357
              +++ GM A+ VLDI Q LYE HKL TYPR+D  YLP        QV +A+ +T PAL 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  358  kaVSEADGKIRSKAWNDSKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPP  417
              V+  D ++ S+ WND K+ AHH+IIPT   G+ + L+  E ++Y L+  +YL QF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  418  FEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAG--TLPALKEGEQLLC  475
             E + +   + I+G LF++++  ++K+GWK+L+G   +DDE+++G  TLPA++ G+  +C
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VC  469

Query  476  ERGELQEKM--TQPPKSFTDATLLAAMTGIARYVQDPEIRKTLRDTDGLGTEATRAGIID  533
            +    ++K+  T+PP ++ D+TL+AAMT  A +V D+ ++K L++  G+GTEATRAGIID
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  534  LLFKRRFLVRQGKSIKATPTGRALVQALPATATTPDMTALWEQSLGQIAERHGSYQQFMG  593
             L+KR FLVR+ K++K+TP GR LV+ LP+T T P++TALWEQ L+++A  + S ++FM+
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  594  PLTEQLNGLIEGARQDS  610
              ++ ++ L+  +R ++
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  419 bits (1578),  Expect = 2e-118, Method: Compositional matrix adjust.
 Identities = 260/621 (42%), Positives = 399/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEANEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+ +EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKESTQRLLISDLNLPAVKRALSSMRSNREFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDANGTFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AKVTESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPMEHYSQAGTVTTAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLP+    +   V +A+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQVAVQGADLTLKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ  V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGTFVAKGRQLVSPGWKALMGKTDKEDE---GIDAVPPLPEGT  476
            F P      +   F+I+G  F ++G  LV PGWK+L GK   +DE   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEASLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + +++L+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSPAGRGLIHALPEDSTYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+P GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDSLMAQVKAGPIP  617
            M    Q++  L+AQ ++ P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  418 bits (1575),  Expect = 4e-118, Method: Compositional matrix adjust.
 Identities = 270/667 (41%), Positives = 436/667 (66%), Gaps = 15/667 (2%)

Query  1    MKLFIAEKPSMARELAKCLPEPHQRGNGCIRTGGGIVTWAYGHVLQQAEPQDYDPKY-KR  59
            M+L + EKPS +R++AK L  + QRG+G +   G  VTWA GH+L+ AEP+ Y+ +Y K 
Sbjct  1    MRLVLCEKPSQGRDIAKFL-GATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WNADDLPIIPQKWKLLVSPASKDQFKVITDLIASPDVDTIVNAGDPDREGQLLIDEILDY  119
            W +D LP++PQ+WKL+V + +K QF VI  L+   +VD +V A D+DREG+++  E+LDY
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLK--QVDEVVIATDADREGEVIARELLDY  117

Query  120  VGNKKPVERILLNALDEKSIHESLDDLRSNGDFVHLKESALARSRADWLIGMNLSRAYTL  179
               +  V R+ ++ALD+ SI+ +L DL++++    L  ++++RSRADWLIGMNL+R +TL
Sbjct  118  CKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTL  177

Query  180  AARRQGHRVVFPIGRVKTPTLALVVRRQRELDNFVPVTYYVVKADFLHKNGVIRAQWQPR  239
             +R  G   V+++GRV+TPTLA+VV+R+RE+DNFV+  Y+ V A    +  ++ ++W P 
Sbjct  178  LGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPA  237

Query  240  DTQGGLDPEGRCVDEKTARSILERLQARPDGTIVENKKTKKKEAQRLPLSLSSLQVLAGK  299
                  D E RC++   A  +++  +  P ++I++ +  +KK++  L++SLS+LQ   ++
Sbjct  238  AQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSR  295

Query  300  RYGYTPQQVLDTAQELYE-RKLTTYPRSDCEYLPVNQRKDVPRILQNIGALEAGKLAEWA  358
            + G  +Q VLD AQ LYE +KLTTYPR+DC YLP++ R ++P++L  + + +++  +   
Sbjct  296  HWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPV-V  354

Query  359  AGADGKIRSRAWNDSKITAHHAIIPTTVACPFDKLTSMQQHIYYLVAQAYLAQFYPIHEY  418
            A+ D ++ SR WND KITAHH+IIPT  +  + KL+  ++++Y LV   YLAQF P  E 
Sbjct  355  ASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEI  414

Query  419  DQTRMVIEAADETFIAHGKTVTVPGWKVLYQSDKHDEEDE-EKGTLPAVRKGDGVHYQNG  477
            D T   ++ +++ F ++G+ +  PGWK L+    +D+ED+    TLPA++ G+  + Q +
Sbjct  415  DVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGA  474

Query  478  QVDKKATKPPPRFTPSTLLAAMKEIYKYVKDESLKKKLKEVQGIGTEATRATIIQELIQR  537
            +     TKPP+ +  +TL+AAM +   +V D +LKK LKE  GIGTEATRA II+ L++R
Sbjct  475  EQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKR  534

Query  538  KFLTTEGKKKYLKPTDDAYLLVDSLPDEMLYPDETAVWEERLYQMSLGKDDLNHFLHDQL  597
             FL  E  KK LK+T  +  LVD LP+ +  P+ TA+WE+ L +++ G+  L++F+  Q 
Sbjct  535  GFLVRE--KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQS  592

Query  598  SFLDTLVTAARK--VVMHLAGIKVCPVCGSAMVKRHGKYGDFYGCSNYPSCRHTEPVEGE  655
              +  LV+ +R   + M+ +    CPVCG+  ++R+GK G F GC +YP C+    V+  
Sbjct  593  QWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGI--VNNG  650

Query  656  KKRPDAK  662
            +K P ++
Sbjct  651  NKGPRGR  657

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  418 bits (1572),  Expect = 5e-118, Method: Compositional matrix adjust.
 Identities = 260/621 (42%), Positives = 398/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEANEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+ +EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKESTQRLLISDLNLPAVKRALSSMRGNREFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++ +    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDANGTFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AKVTESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPMEHYSQAGTVTTAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLP+    +   V +A+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQGAVQGADLALKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ  V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDE---GIDAVPPLPEGT  476
            F P      +   F+I+G  F ++G  LV PGWK+L GK   +DE   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEASLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + +++L+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSPAGRGLIHALPEDSTYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+P GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMAQVKAGPIP  617
            M    Q++  L+AQ ++ P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  417 bits (1569),  Expect = 1e-117, Method: Compositional matrix adjust.
 Identities = 261/621 (43%), Positives = 399/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AIVKESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGIFIAKGRQLVSSGWKALMGKTDKEDE---GIDAVPPLSEGT  476
            F P      +   F+I+G +F ++G  LV +GWK+L GK   +DE   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSIISSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+  GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMSQVKSGPIP  617
            M    Q++  L++Q +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  417 bits (1571),  Expect = 6e-118, Method: Compositional matrix adjust.
 Identities = 263/621 (43%), Positives = 399/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AIVKESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGIFIAKGRQLVSPGWKALMGKTDKEDE---GIDTVPPLSEGT  476
            F P      +   F+I+G +F ++G  LV PGWK+L GK   +DE   G  T+P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+  GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMSQVKSGPIP  617
            M    Q++  L++Q +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  416 bits (1566),  Expect = 2e-117, Method: Compositional matrix adjust.
 Identities = 263/621 (43%), Positives = 398/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALNSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL  ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AIVKESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIVNNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+V   
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMRVYQLVASQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E  VYQLV  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGIFIAKGRQLVSSGWKALMGKTDKEDE---GIDAVPPLSEGT  476
            F P      +   F+I+G +F ++G  LV +GWK+L GK   +DE   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+  GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMSQVKSGPIP  617
            M    Q++  L++Q +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  416 bits (1565),  Expect = 2e-117, Method: Compositional matrix adjust.
 Identities = 260/621 (42%), Positives = 417/621 (68%), Gaps = 23/621 (3%)

Query  1    MRLIIAEKPSLGRAIAAVLPQPHSKGEGFVRAANGDVVSWCIGHLLEQAQPEAYNPQY-K  59
            MRL++ EKPS GR IA  L   + +GEGF+ ++ G  V+W  GHLLE A+PE Y  QY K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLNGP-GVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRLDHLPIVPNEWQLEAKAQTRKQLSVLRKLVKEADSIVHAGDPDREGQLLVDEVIAFL  119
             WR D LP++P++W+L  KA+++ Q++V+ +L+K+ D +V A D+DREG+++  E++ + 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  KVPATKRSSMQRLLVSDLNPQAVTRALQQLRPNKDFIPLSVSALARSRADWLYGINLTRA  179
            K     ++ + RL +S L+  ++  AL +L+P+    +L  ++++RSRADWL G+NLTR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLKGQQGGLKAVLSVGRVQTPILGLIVRRDNEIADFISKPFYEVFAALHLNAEQPLSFY  239
            +TL G+++G+  VLSVGRVQTP L+++V+RD EI +F+SKP++EV+A++ +N+   + F 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG---VLFP  231

Query  240  AKWLPSES-CQAHQDDEGRVLNPKLAHNVAQRIRQ-QAASVTSIERKLKKQAAPLPYNLS  297
            +KW+P+   C    D+E R +++ +A +V Q  RQ  +A++ + +   KKQ+APL+++LS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  298  SLQIDAAKAFGLSAQQVLDSCQSLYEKHQLITYPRSDCRYLPTEHYARRSVVLSAIANSA  357
            +LQ   ++  G++AQ VLD  Q LYE H+L TYPR+DC YLP       + VLSA+  + 
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  358  NELASGVAQADTQYRSKAWDDKKVEAHHAIIPTEKSLDIQRLSRYEQKVYQLIARQYVMQ  417
              L + VA  DTQ+ S+ W+DKK+ AHH+IIPT  + D+ +LS  E++VYQL+  +Y+ Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  418  FYPAFEYADTRIELDIAGGVFVATERETIKLGWKQLLPARKQSDQNADQDPSRPSLPKLE  477
            F P  E   T   ++I+G +F +     +K GWK L+    + D   +++ +  +LP ++
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDD---EDNTGETTLPAMQ  464

Query  478  KGQVLWSGEPDVQEK--NTQPPAYFTDATLLAAMTGIARFVTDSELKKILKETDGLGTEA  535
             GQV      + ++K  +T+PPA + D+TL+AAMT  A FVTD+ LKK+LKE  G+GTEA
Sbjct  465  AGQV--CQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  536  TRAGIIELLFKRRFLQREGKSIRATDLGKALVAALPEACTLPDMTAQWEKQLNDITQKLL  595
            TRAGII+ L+KR FL RE K++++T LG+ LV  LP + T P++TA WE+ L++++   +
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  596  NYDQFMQPLALQLDALINQAK  616
            + D+FM   +  +  L+ Q++
Sbjct  583  SLDDFMAKQSQWVSQLVAQGR  603

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  416 bits (1564),  Expect = 3e-117, Method: Compositional matrix adjust.
 Identities = 279/666 (42%), Positives = 423/666 (64%), Gaps = 23/666 (3%)

Query  1    MRLFIAEKPSVAKAIAGELGVTGKGDGYIECGGDKVTWCFGHMLEQADPDEYTPDDVPTG  60
            MRL + EKPS ++ IA  LG T +G+G+++  G  VTW  GH+LE A+P+ Y  +    G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQ---YG  57

Query  61   KSGKKLWRVDELPIIPQTWILHPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            K+    WR D LP++PQ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  58   KP----WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFKSSKPTRRFWVSAQDSVSVKRGLAALKDNTTYKGWADAARGRQRADWLIGMNLSR  180
            +L+  K      R+W+SA D  S++ +LA L  ++   +   A+ GR RADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVNRDREIEAFKPVPYHTIRAAIQHEGGTFMAA  240
             +TL ++ +G   +L+VGRVQTPTLA+VV+RDREI+ F + PY  + A++  +G  F + 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIATYKQEAKKKNQPLAFALSDITA  299
            W +  +    D E R ++++VA  +V   +  P ++I   + E KK++ PLAF+LS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASARYGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAVKHVNPELA  359
              S + G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL AV   +P L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  GLVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAGLSERERNIYELIVRAYLAQFYPL  419
             +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEYMQTTVGVEIAGENFAASGKVVTRNGWRDVFDQadeedakegddengaQTLPVMKQGD  479
             E   T    +I+G+ F + G+V+ + GW+ +F++  E+D  + ++     TLP M+ G+
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET----TLPAMQAGQ  467

Query  480  GVTCTEATRRDAKTKPPARFTEGTLIRAMENIHKFVSDPEHKKMLREGDGIGTSATRASI  539
                  A ++  +TKPPA + +GTLI AM N   FV+D+  KK+L+E  GIGT ATRA+I
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  540  ISELKRRAFLETKGKQIVSTTLGRSVIDALPEVVRSPVLTALYERMLKGVELGTAALDAF  599
            I  L +R+FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  +LD F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  600  ITKQEQFIRDQVTKANSGAVSIAGGKEAAPVSSLHKCMACGTGLSRRPSKKKGQFWWGCA  659
            ++KQ Q + + V+++ S ++++    +A+P ++   C  CG    +R + K G F WGC 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNG-KSGLF-WGCL  638

Query  660  NFPTCK  665
            ++P CK
Sbjct  639  KYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  415 bits (1563),  Expect = 3e-117, Method: Compositional matrix adjust.
 Identities = 262/630 (42%), Positives = 418/630 (67%), Gaps = 18/630 (2%)

Query  1    MILYIAEKPSLGRAIADVLPKPHKKGEGYITAANGDTVSWCIGHLLEQAEPDSYDPAF-K  59
            M L + EKPS GR IA  L   ++ GEG++ ++ G TV+W  GHLLE AEP+ Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLNGP-GVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   SWSFDHLPIVPQQWKMTPKSKTRGQLSVLRKLVKQASQLVNAGDPDREGQLLVDEVIAYL  119
            +W  D LP++PQQWK+  K+ +++Q++V+ +L+KQ  ++V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GVKGDKLEQTQRLLVSDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRA  179
              +G  +    RL +S L+  +++ AL++L+++    +L  ++++RSRADWL GMN+TR 
Sbjct  119  KFQGRVF----RLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEAIEHFVSKPFYEVLANLYTQEQAHFKAK  239
            +TL GR  G   VLSVGRVQTP L++VV+RD  I++FVSKP++EV+A + + +   F +K
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATM-AVNGVLFPSK  233

Query  240  WQPSEACQPYMDEEGRVLSRRLAENVVGRITEQP-AKVTDLQAKDKQQGQPLPYNLSSLQ  298
            W P+     Y DEE R +   +A +VV    + P A + + Q   K+Q+ PL+++LS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IDAAKRFGMSAKTVLDTCQSLYEKHKLITYPRSDSRYLPKEQLALAPSVIGAVLKGAGEL  358
               +++ GM+A+TVLD  Q LYE HKL TYPR+D  YLP       P V++AV+     L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  TAQCAAPDLKIVSKAWNDAKVDAHHAIVPTEKVANLSALTQAEKQIYLQLAR-QYLAQFY  417
             +  A+ D ++VS+ WND K+ AHH+I+PT   ++LS L++AE+++Y QL R +YLAQF 
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVY-QLVRLHYLAQFL  409

Query  418  PVYRYHETQVEVEIAGGHFHTKAKQEIALGWKQLFPKRSDDKTDGEGDEALAQLPPLHKG  477
            P    + T+   +I+G  F+T+++  +  GWK LF K S+D  D  G+ +   LP+++ G
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT---LPAMQAG  466

Query  478  QMLHSGQGELIEKQTQPPKAFTDATLLSAMTGISRYVTNPEIRKILKETDGLGTEATRAG  537
            Q+ +   +E    QT+PP ++ D+TL++AMT  + +VT++ ++K+LKE  G+GTEATRAG
Sbjct  467  QVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAG  526

Query  538  IIELLFKRGFLARQGKSIVSTPVGRGLINSLPESATTPDMTALWESHLDAISRKEAKYLS  597
            II+ L+KRGFL R+ K++ STP+GR L++ LP + T P++TALWE  LD ++        
Sbjct  527  IIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDD  586

Query  598  FMAPLVESLNGLIMQAGAQLPKALQGVEAP  627
            FMA   + ++ L+ Q+ +Q P ++Q+  +P
Sbjct  587  FMAKQSQWVSQLVAQGRSQ-PLTMQAPPSP  615

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  415 bits (1561),  Expect = 4e-117, Method: Compositional matrix adjust.
 Identities = 261/621 (43%), Positives = 398/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKDATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLSRKLVENVANRIANQP-AKVTESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R +   +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGSVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVQGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDD---GIDAVPPLAEGT  476
            F P      +   F+I+G  F ++G  LV PGWK+L GK   +D+   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSPAGRGLIHALPMDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+P GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMGEVKSGPIP  617
            M    Q++  L+++ +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  415 bits (1561),  Expect = 4e-117, Method: Compositional matrix adjust.
 Identities = 261/621 (43%), Positives = 398/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKDATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLSRKLVENVANRIANQP-AKVTESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R +   +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGSVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVQGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDD---GIDAVPPLAEGT  476
            F P      +   F+I+G  F ++G  LV PGWK+L GK   +D+   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSPAGRGLIHALPMDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+P GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMGEVKSGPIP  617
            M    Q++  L+++ +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  415 bits (1561),  Expect = 4e-117, Method: Compositional matrix adjust.
 Identities = 258/621 (42%), Positives = 400/621 (65%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPEQWQLRPRKTSSKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++P+QW+L  +  +  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKQATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL+ ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NF++K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWKPSEA-CKPWQDEEGRVLNRKLVENVAARIKNQP-ATVKESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V    ++ P A++ + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPMEHYAQVGSVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLP+    ++  V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVQGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAIYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDD---GIDAVPPLAEGT  476
            F P      +   F+I+G  F ++G  LV PGWK+L GK   +D+   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSPAGRGLVHALPQDATYPDMTAHWEFQLQGMAEKNQAYQPF  596
            +DTL+KR +L R+ K++ S+P GR LV+ LP   T P++TA WE  L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDSLMGEVKSGPIP  617
            M    Q++  L+++ +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  413 bits (1555),  Expect = 1e-116, Method: Compositional matrix adjust.
 Identities = 280/666 (43%), Positives = 418/666 (63%), Gaps = 23/666 (3%)

Query  1    MRLFIAEKPSVAKAIAGELGITGKGDGFIECGGDKVTWCFGHMLEQADPDEYTPDDVPTG  60
            MRL + EKPS ++ IA  LG T +G+GF++  G  VTW  GH+LE A+P+ Y  +    G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQ---YG  57

Query  61   KSGKKLWRVDELPIIPQTWVLHPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            K+    WR D LP++PQ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  58   KP----WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFKSSKPARRFWVSAQDSVSVKRGLAALKENTTYKGWADAARGRQRADWLIGMNLSR  180
            +L+  K      R+W+SA D  S++ +LA L  ++   +   A+ GR RADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVGRDREIEAFKPVPYHTIKAVVEHAGGSFAAA  240
             +TL ++ +G   +L+VGRVQTPTLA+VV RDREI+ F + PY  + A +   G  F++ 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIATYKQEAKKKNQPLAFALSDITA  299
            W +  +    D E R ++++VA  +V   +  P ++I   + E KK++ PLAF+LS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASARYGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAVKHVNPELA  359
              S + G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL AV   +P L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  GLVDAADPRIKSKTWDDSKITAHHGIVPTMQKGSKAGLSERERNIYELIVRAYLAQFYPL  419
             +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEYMQTTVGVEIAGENFAASGKVVTRNGWRDVFEQadeedakegddengaQTLPPMKQGD  479
             E   T    +I+G+ F + G+V+ + GW+ +F +  E+D  + ++     TLP+M+ G+
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET----TLPAMQAGQ  467

Query  480  GVTCTEATRRDAKTKPPARFTEGTLIRAMENIHKFVSDPEHKKMLREGDGIGTSATRASI  539
                  A ++  +TKPPA + +GTLI AM N   FV+D+  KK+L+E  GIGT ATRA+I
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  540  ISELKRREFLETKGKQIVSTTLGRSVIDALPEVVRSPVLTALYERMLKGVELGTAALDAF  599
            I  L +R FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  +LD F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  600  ITKQEAFIRDQVAKANSGAVSIAGGKEATPVSSLHKCMACGNGLSRRPAKRKGQFWWGCS  659
            ++KQ   + + VA++ S ++++    +A P ++   C  CG    +R +K  G F WGC 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNGK-SGLF-WGCL  638

Query  660  NFPTCK  665
            ++P CK
Sbjct  639  KYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  413 bits (1555),  Expect = 1e-116, Method: Compositional matrix adjust.
 Identities = 280/666 (43%), Positives = 418/666 (63%), Gaps = 23/666 (3%)

Query  1    MRLFIAEKPSVAKAIAGELGITGKGDGFIECGGDKVTWCFGHMLEQADPDEYTPDDVPTG  60
            MRL + EKPS ++ IA  LG T +G+GF++  G  VTW  GH+LE A+P+ Y  +    G
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQ---YG  57

Query  61   KSGKKLWRVDELPIIPQTWVLHPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE  120
            K+    WR D LP++PQ W L  K DAK Q+AVI +LLK+  E+V A D+DREG+++  E
Sbjct  58   KP----WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFKSSKPARRFWVSAQDSVSVKRGLAALKENTTYKGWADAARGRQRADWLIGMNLSR  180
            +L+  K      R+W+SA D  S++ +LA L  ++   +   A+ GR RADWLIGMNL+R
Sbjct  114  LLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTR  173

Query  181  AYTLRAQRGGSRALLTVGRVQTPTLALVVGRDREIEAFKPVPYHTIKAVVEHAGGSFAAA  240
             +TL ++ +G   +L+VGRVQTPTLA+VV RDREI+ F + PY  + A +   G  F++ 
Sbjct  174  LFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSK  233

Query  241  WKAKEDQAGLDSEGRlvdtavadalvaavKGQP-GTIATYKQEAKKKNQPLAFALSDITA  299
            W +  +    D E R ++++VA  +V   +  P ++I   + E KK++ PLAF+LS +  
Sbjct  234  WVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  300  LASARYGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAVKHVNPELA  359
              S + G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL AV   +P L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  360  GLVDAADPRIKSKTWDDSKITAHHGIVPTMQKGSKAGLSERERNIYELIVRAYLAQFYPL  419
             +V + D ++ S+ W+D KITAHHGI+PT + G  + LS+ ERN+Y+L+   YLAQF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  420  HEYMQTTVGVEIAGENFAASGKVVTRNGWRDVFEQadeedakegddengaQTLPPMKQGD  479
             E   T    +I+G+ F + G+V+ + GW+ +F +  E+D  + ++     TLP+M+ G+
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGET----TLPAMQAGQ  467

Query  480  GVTCTEATRRDAKTKPPARFTEGTLIRAMENIHKFVSDPEHKKMLREGDGIGTSATRASI  539
                  A ++  +TKPPA + +GTLI AM N   FV+D+  KK+L+E  GIGT ATRA+I
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  540  ISELKRREFLETKGKQIVSTTLGRSVIDALPEVVRSPVLTALYERMLKGVELGTAALDAF  599
            I  L +R FL    K + ST LGR+++D LP  + +P LTAL E+ML  V  G  +LD F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  600  ITKQEAFIRDQVAKANSGAVSIAGGKEATPVSSLHKCMACGNGLSRRPAKRKGQFWWGCS  659
            ++KQ   + + VA++ S ++++    +A P ++   C  CG    +R +K  G F WGC 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTM----QAPPSPP---CPVCGGKTLQRNGK-SGLF-WGCL  638

Query  660  NFPTCK  665
            ++P CK
Sbjct  639  KYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  412 bits (1552),  Expect = 2e-116, Method: Compositional matrix adjust.
 Identities = 261/621 (43%), Positives = 397/621 (64%), Gaps = 20/621 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+ ++GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++PQQW+L  +  A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSKTKKEATQRLLISDLNLPAVKRALNSMRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +    RL +S L+ ++++ AL  ++++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIR  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV+K YF    +I+    NG + + 
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYF---EVIATMAVNGVL-FP  231

Query  242  ARWRPSEA-CKPWQDEEGRVLNRKLVENVANRIANQP-AIVKESEQKQTKQSAPLPYSLS  299
            ++W P+   C    DEE R ++  +  +V +   + P A + + +  + KQSAPL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+DC YLPL    +   V SA+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELQSAVKGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQ  419
              LQ+ V + D  + S+ WNDKK+ AHH+IIPT   ++++ LS+ E +VYQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAAVYAEAKLVFDIAGGIFIAKGRQLVSLGWKALMGKTDKEDE---GIDAVPPLSEGT  476
            F P      +   F+I+G +F ++G  LV  GWK+L GK   +DE   G  ++P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGI  536
            V   + +E K  +T PP  + ++TL+ AMT  A +V+D  LKK+L++  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ S+  GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MQALEQRIDGLMSQVKSGPIP  617
            M    Q++  L++Q +S P+ 
Sbjct  588  MAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  405 bits (1525),  Expect = 3e-114, Method: Compositional matrix adjust.
 Identities = 268/617 (44%), Positives = 427/617 (70%), Gaps = 18/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAY-K  59
            MRL + EKPS GR IA  L   ++ G+GF++ + G  VTW  GHLLE AEP+ Y+  Y K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRMESLPIVPSQWQLVAKPKTKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFL  119
             WR + LP++P QW+LV K+ +K+Q++VI+RLLKQ D VV A D+DREG+++  E++D+ 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYT  179
             + + R V+R  +S L+ +++R AL  L+ +    +L  ++++RSRADWL G+N+TR +T
Sbjct  119  KF-QGR-VFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFT  176

Query  180  LLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNERFSAKWL  239
            LLGR +G +++LSVGRVQTP L++VV+RD EI+ FV+KP+FEV+A +  +G   F++KW+
Sbjct  177  LLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV-LFPSKWV  235

Query  240  PSEA-CLPWQDEEGRVLNRALAAKVVERI-QGQPALVEEVEEQARKQAAPLPYNLSSLQI  297
            P+   C    DEE R ++ ++AA+VV+   Q   A + + + + +KQ+APL+++LS+LQ 
Sbjct  236  PAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  298  DAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALA  357
              +++ GM A+ VLD+ Q LYE HKL TYPR+D   LP    +   QV  A+ +T PAL 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  358  KAVSEADGKIRSKAWNDGKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPP  417
              V+  D ++ S+ WND K+ AHH+IIPT   G+ + L+  E ++Y L+  +YL QF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  418  FEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAG--TLPALKEGEQLLC  475
             E + +   + I+G LF++++  ++K+GWK+L+G   +DDE+++G  TLPA++ G+  +C
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VC  469

Query  476  ERGALLEKM--TQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIID  533
            +  +  +K+  T++P ++ D+TL+AAMT  A +V D+ ++K L+E  G+GTEATRAGIID
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  534  LLFKRRFLVRQGKSIKGTPTGRalilalpatattpdmtalWEQHLGRIAERQTSYQQFMG  593
             L+KR FLVR+ K++K+TP GR L+  LP+T T P++TALWEQ L+ +A  + S ++FM+
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  594  PLTEQLNGLIDGARQDS  610
              ++ ++ L+  +R ++
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  403 bits (1515),  Expect = 2e-113, Method: Compositional matrix adjust.
 Identities = 258/618 (42%), Positives = 416/618 (68%), Gaps = 17/618 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHTRGDGFIQCGEGDTVTWCIGHLLEQAEPDAYDERF-K  59
            MRL + EKPS GR IA  L   + RG+GF++ G G TVTW  GHLLE AEP+ Y+E++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   LWRMEHLPIVPSQWKLIPKKETLKQFKVVEKLIKQADQIIHAGDPDREGQLLVDEVFGYL  119
             WR + LP++P QWKL+ K ++  QF V+++L+KQ D+++ A D+DREG+++  E+++Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLESEKRNQIQRCLISDLNPNAVKKAIEKLQNNRDFIPLATSALARARADWLYGINMTRA  179
            ++++    ++ R  +S L+  +++ A+  L  +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRWAGYSGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDYFEVLAHVVVPETQEQFKA  239
            +TL GR AG + VLSVGRVQTP L+++V+RD EI++FV+K YFEV+A + V      F +
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL--FPS  232

Query  240  QWQPSKACEDYQDEEGRVLSRPLAENVVKRITNQP-AKVVDYQDKMENETAPLPYSLSAL  298
            +W P+    +Y DEE R +   +A +VV+   + P A +++ Q    +++APL++SLS+L
Sbjct  233  KWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  299  QIDAARRHGLSAQAVLDICQKLYETHKLITYPRSDNRYLPNEHYADRHKVMAAISHHLTE  358
            Q   +R+ G++AQ+VLDI QKLYETHKL TYPR+D  YLP     +  +V++A+      
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  359  YTEKPEAIDSNRKNRCWNDSKVEAHHAIIPTARQGNVN-LTESERNVYRLIARQYLLQFC  417
                  ++D++  +R WND K+ AHH+IIPT + G+++ L+++ERNVY+L+  +YL QF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PDAEYRKGKIELNIAGGVFTASARNLIVAGWKSLLGK---EDSDEIFEPLLPKVQKGQTL  474
            P+ E       +NI+G +F + +  L+ +GWKSL+GK   +D D+  E  LP +Q GQ  
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  475  HCEKGEIVEKKTQPPRHFTDASLMSAMTGIARFVQDKQLKKILRETDGLGTEATRSGIIE  534
            + + +E    +T+PP  + D++L++AMT  A FV D  LKK+L+E  G+GTEATR+GII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  535  LLFKRGFLIKKGRSIHSTETGRTLIQALPEIATQPDMTAHWEMQLTDMSKKQVSYQQFMA  594
             L+KRGFL++  +++ ST  GR L++ LP   T+P++TA WE  L +++  +VS ++FMA
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  595  QLTGRLPDLLRSPNSQVL  612
            + + ++++L+    SQ L
Sbjct  590  KQSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  400 bits (1506),  Expect = 1e-112, Method: Compositional matrix adjust.
 Identities = 254/608 (42%), Positives = 399/608 (66%), Gaps = 22/608 (3%)

Query  25   MILYIAEKPSLGRAIAEVLPKPHKKGEGYIELGNGDCVTWCIGHLLEQAEPDAYSPEY-K  83
            M L + EKPS GR IA  L   ++ GEG+++ G G  VTW  GHLLE AEP+ Y+ +Y K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  84   QWQLAHLPIIPAEWKLTPRSSAKSQLAVVKRLIKQASSLVHAGDPDREGQLLVDEVISHA  143
             W+   LP++P +WKL  ++ AK+Q+AV++RL+KQ   +V A D+DREG+++  E++   
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  144  KVSASKLASTQRLLISDLNPDAVRRALGQLRSNKEFVPLATSALARSRADWLYGLNMTRA  203
            K  +  +    RL +S L+  ++R AL++L+++    +L  ++++RSRADWL G+N+TR 
Sbjct  119  KFQGRVF----RLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  204  YTLQGRKVGYAGVLSVGRVQTPLLGLVVRRDLDIEHFEPKDHYEVLAHITTDKGESFCAK  263
            +TL GR  G + VLSVGRVQTP L++VV+RD +I++F +K  +EV+A ++ + G  F +K
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVN-GVLFPSK  233

Query  264  WQPSEACQPYMDEEGRVLSRRLAETVV--SRIGGKPALVEHVSHKDKKQAPPLLYSLSAL  321
            W P+     Y DEE R +   +A  VV   R    +A+++   ++ KKQ++PL +SLS+L
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIER-KKQSAPLAFSLSTL  289

Query  322  QIDCAKRFGMSAKEVLDTAQSLYERHKLITYPRSDSRHLPKEQLALVPDVLSAVSANAPE  381
            Q  C+++ GM+A+ VLD AQ LYE HKL TYPR+D   LP      +P+VLSAV +  P 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  382  LLEGAPSPDLHLVSKAWDDSKVDAHHAIVPTGKRTALSQLNQRERQLYLHIARQYLAQFY  441
            L    +S D ++VS+ W+D K+ AHH+I+PT     LS+L++ ER++Y  +  +YLAQF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  442  PNRLLADTEIQLIIEGGSFIARASVERAPGWRVLFQGRSTEQDEAKEPQETDASQKTPLP  501
            P+  +  TE  + I G  F +R++V   PGW+ LF G+ +E+DE       D +  T LP
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLF-GKMSEDDE-------DNTGETTLP  461

Query  502  ALNKGDIARCCHGELLAKQTQPPKHFTDATLLSAMTGIARYVSSPDIKRILKDTDGLGTE  561
            A++ G++ +   +E    QT+PP  + D+TL++AMT  A +V+ + +K++LK+  G+GTE
Sbjct  462  AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTE  521

Query  562  ATRAGIIELLFKRGFLVRQGKSIVASQAGRGLIASLPEVATTADMTALWERQLSDICQRQ  621
            ATRAGII+ L+KRGFLVR+ K++ ++  GR L+  LP   T +++TALWE+ L ++   +
Sbjct  522  ATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGR  581

Query  622  LSYKGFMT  629
            +S  +FM+
Sbjct  582  VSLDDFMA  589

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  400 bits (1506),  Expect = 1e-112, Method: Compositional matrix adjust.
 Identities = 255/635 (41%), Positives = 412/635 (65%), Gaps = 23/635 (3%)

Query  1    MILYIAEKPSLGRAIADVLPKPLKKGEGFIRAANGDCVSWCVGHLLEQAEPDAYSPEY-K  59
            M L + EKPS GR IA  L    ++GEGF+ ++    V+W  GHLLE AEP+ Y+ +Y K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGAT-QRGEGFLNGPGVT-VTWARGHLLETAEPEVYGEQYGK  58

Query  60   SWKFEHLPIVPDVWKMKPKYKMRGQISVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHL  119
            +W+ + LP++P+ WK+  K   ++Q++V+  L+K+  ++V A D+DREG+++  E++   
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GVKGNKLTQAKRLLISDLNPQAVKRALGQLRLNREFIPLSTSALARSRADWLYGMNMTRA  179
              +G  +    RL +S L+  +++ AL++L+ +    +L  ++++RSRADWL GMN+TR 
Sbjct  119  KFQGRVF----RLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIQGRKVGYQGVLSVGRVQTPILGLVVRRDEEIAHFVSKPFFEVIAHLTAEPQQTFTAK  239
            +T+ GR  G   VLSVGRVQTP L++VV+RD EI +FVSKP+FEVIA ++ +    F +K
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV-LFPSK  233

Query  240  WQPSEACQPYMDEDGRVLSKGLAQNVVGRITGQP-ATVEKVNAQDKKQNAPLPYNLSSLQ  298
            W P+     Y DE+ R +  G+A +VV      P A++ + + + KKQ+APL+++LS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IDAAKRFGMSAKTVLDTCQSLYERHKLITYPRSDSRYLPQEQHGMAPSVINTVNKGAPEL  358
               +++ GM+A+TVLD  Q LYE HKL TYPR+D  YLP   +   P V+++V    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  TQGIDAPNAKLKSKAWNDKKVDAHHAIIPTEKVANLSSLSPAEKQVYLLVARQYLMQFYS  418
               + + ++++ S+ WNDKK+ AHH+IIPT   ++LS LS AE++VY LV  +YL QF +
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  419  AYQYKETQVEIIIAGGLFKTKAKQEIAKGWKLLLKQSKASTSSDSNGQDEDELATIPPLT  478
              +   T+  + I+G LF+T+++  +  GWK L+     +  S+ + ++ +E +T+P++ 
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLF-----GKMSEDDEDNTGE-TTLPAMQ  464

Query  479  IGQKLFCDRGQLLEK--QTQPPKHFTDATLLSAMTGISRFVTDVEIRKILKDTDGLGTEA  536
             GQ   C+     +K  QT+PP  + D+TL++AMT  + FVTD  ++K+LK+  G+GTEA
Sbjct  465  AGQ--VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  537  TRAGIIELLFKRSFLVRQGKTIVATDVGKGLINSLPLSATTPDMTALWENNLDSMSRKET  596
            TRAGII+ L+KR+FLVR+ KT+ +T +G+ L++ LP + T P++TALWE+ LD ++    
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  597  QYQAFMQPLISKLDELITQAGSVLPTALQGVKSPT  631
              + FM      + +L++Q G   P ++Q+  SP 
Sbjct  583  SLDDFMAKQSQWVSQLVAQ-GRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  397 bits (1492),  Expect = 1e-111, Method: Compositional matrix adjust.
 Identities = 248/618 (41%), Positives = 410/618 (67%), Gaps = 25/618 (4%)

Query  1    MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDAYDPKF-K  59
            MRL + EKPS +R IA  L  + QRG+GF++ G    VTW  GHLLE AEP+ Y+ ++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLG-ATQRGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYA  119
             WR + LP++P++W+L+ + + K Q++V+++L+ Q D +V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRA  179
            ++    +++++R  +S L+ +++  A+  L P+    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIRGRQTGYHGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVLAWINPetkeektle  239
            +T+ GR++G   VLSVGRVQTP L+++V+RD EI++F +K +FEV+A          T+ 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIA----------TMA  224

Query  240  kstALFSALWQPSKACEDYQDDDSRVLSKGLAENVVKRITNQP-AEVTEYKDVREKETAP  298
             +  LF++ W P+    +Y D++ R +  G+A +VV+   + P A + + +  R K++AP
Sbjct  225  VNGVLFPSKWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAP  281

Query  299  LPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLN  358
            L++SLS+LQ   +++ GM+AQ+VLD  Q+LYETH+L TYPR+DC YLP     E  +VL+
Sbjct  282  LAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLS  341

Query  359  AISTHCEAYQVLPNVISTEQRNRCWNDKKVEAHHAIIPTAKNRPVN-LTQEERNIYSLIA  417
            A+     A Q +   + T+  +R WNDKK+ AHH+IIPT     ++ L++ ERN+Y L+ 
Sbjct  342  AVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVR  401

Query  418  RQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGK---EDDTENQEPLLP  474
             +YL QF P+ E   +  T+NI+G  F +++  L  +GWK L+GK   +D+ +  E  LP
Sbjct  402  LHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLP  461

Query  475  IVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTE  534
             ++ GQ+ + + +E    +T+PP P+ D+TL++AMT  A FV D  LKK+L+E  G+GTE
Sbjct  462  AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTE  521

Query  535  ATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPDIATQPDMTAHWESQLTDISQKQ  594
            ATRAGII+ L+KRGFL +  + + ST  GR L++ LP+  T+P++TA WE  L +++  +
Sbjct  522  ATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGR  581

Query  595  ATYQQFMHNLNQMLPDLV  612
             + ++FM + +Q +++LV
Sbjct  582  VSLDDFMAKQSQWVSQLV  599

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  397 bits (1493),  Expect = 1e-111, Method: Compositional matrix adjust.
 Identities = 249/618 (41%), Positives = 409/618 (67%), Gaps = 25/618 (4%)

Query  1    MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDVYDPKF-K  59
            MRL + EKPS +R IA  L  + QRG+GF++ G    VTW  GHLLE AEP+VY+ ++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLG-ATQRGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYA  119
             WR + LP++P++W+L+ + + K Q++V+++L+ Q D +V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRA  179
            ++    +++++R  +S L+ +++  A+  L P+    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNpeskeektpe  239
            +T+ GR++G + VLSVGRVQTP L+++V+RD EI++F +K +FEV A          T  
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIA----------TMA  224

Query  240  kstALFSALWQPSKACEDYQDDDGRVLSKGLAENVVKRITNQP-AEVTEYKDVREKETAP  298
             +  LF++ W P+    +Y D++ R +  G+A +VV+   + P A + + +  R K++AP
Sbjct  225  VNGVLFPSKWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAP  281

Query  299  LPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLN  358
            L++SLS+LQ   +++ GM+AQ+VLD  Q+LYETH+L TYPR+DC YLP     E  +VL+
Sbjct  282  LAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLS  341

Query  359  AISTHCEAYQRLPNVISTEQRNRCWNDKKVEAHHAIIPTAKNRPI-HLTQEERNIYSLIA  417
            A+     A Q +   + T+  +R WNDKK+ AHH+IIPT     +  L++ ERN+Y L+ 
Sbjct  342  AVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVR  401

Query  418  RQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGK---EDDTENQEPLLP  474
             +YL QF P+ E   +  T+NI+G  F +++  L  +GWK L+GK   +D+ +  E  LP
Sbjct  402  LHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLP  461

Query  475  IVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTE  534
             ++ GQ+ + + +E    +T+PP P+ D+TL++AMT  A FV D  LKK+L+E  G+GTE
Sbjct  462  AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTE  521

Query  535  ATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPDIATQPDMTAHWESQLTDISQKQ  594
            ATRAGII+ L+KRGFL +  + + ST  GR L++ LP+  T+P++TA WE  L +++  +
Sbjct  522  ATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGR  581

Query  595  ATYQQFMHNLNQMLPDLV  612
             + ++FM + +Q +++LV
Sbjct  582  VSLDDFMAKQSQWVSQLV  599

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  396 bits (1488),  Expect = 2e-111, Method: Compositional matrix adjust.
 Identities = 251/626 (41%), Positives = 413/626 (66%), Gaps = 20/626 (3%)

Query  1    MKLYIAEKPSLGRAIAAALPKPQKNHKTHIELANGDVVSWCIGHILAQADPEDYDAEL-K  59
            M+L + EKPS GR IA  L   Q+ +   ++ + G  V+W  GH+L  A+PE Y+ +  K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGE-GFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   KWRMESLPIVPQQWQLKPIARTRSQLTVLRKLVKQADEIIHAGDPDREGQLLVDEVIDYF  119
             WR + LP++PQQW+L   A +++Q++V+ +L+KQ DE++ A D+DREG+++  E++DY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  KLSKTKKANIKRLLISDLNLPAVKRALTSLKPNSDFMPLSISALARSRADWLYGINLTRA  179
            K+    ++ + RL +S L+ ++++ AL+ L P+S   +L  ++++RSRADWL G+NLTR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGQKTGYNSVLSVGRVQTPLLGLVVRREQEISEFVSKPFFQVQAHIALSSKDAVAFT  239
            +TL G+ +G  +VLSVGRVQTP L++VV+R++EI +FVSKP+F+V A +A+   ++V F 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV---NGVLFP  231

Query  240  AKWQPSENCQPYCDEEGRVLVKALAENVVKRIANQP-ATISNIDSNEKQQAAPLPFNLSQ  298
            +KW P+ +   YCDEE R +  ++A +VV+   + P A+I N + + K+Q+APL+F+LS 
Sbjct  232  SKWVPAAQ---YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLST  288

Query  299  LQISAAKQFSMNAKLVLDVCQALYERHKLITYPRSDCRYLPKEQLKQASGIVNTLANSSL  358
            LQ + +++ +M A+ VLD+ Q LYE HKL TYPR+DC YLP     + + +++++  +  
Sbjct  289  LQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDP  348

Query  359  PCNKPAQGANTSFVSKAWNDKKITAHHAIIPTEKSPENINLNTFEKNVYLLIVRQYLVQF  418
            + +    + +T FVS+ WNDKKITAHH+IIPT  + +  +L+  E+NVY L+  +YL QF
Sbjct  349  ALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQF  408

Query  419  YPAYIFQQTKVELLIAGGNFMSQAKTEKQLGWQVLFPKSNKTNNQSKLEHGQEQEQTLPP  478
             P   ++ T   + I+G  F ++++   + GW+ LF K +  ++++        E TLP+
Sbjct  409  LPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNT------GETTLPA  462

Query  479  LTKGQLLHCQQGELIEKHTSPPQSFTDATLLGAMTGISRYVNDAAIKKVLKETDGLGTDA  538
            +  GQ+ + Q +E    +T PP ++ D+TL++AMT  + +V DAA+KKVLKE  G+GT+A
Sbjct  463  MQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEA  522

Query  539  TRAGIIDLLFKRGFLQRQGKAITATKVGVALITALPTMATLPDMTAQWEATLTAISEKNA  598
            TRAGIID L+KRGFL R+ K++ +T +G  L+  LP   T P++TA WE  L  ++    
Sbjct  523  TRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRV  582

Query  599  NYLSFMQPLTVIVNEMVQGASQQSFS  624
            +   FM   +  V+++V  +  Q+++
Sbjct  583  SLDDFMAKQSQWVSQLVAQGRSQPLT  608

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  394 bits (1481),  Expect = 8e-111, Method: Compositional matrix adjust.
 Identities = 247/617 (41%), Positives = 398/617 (65%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYAR  60
            MRL + EKPS GR IA  L   +R G+G+++ G G  VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLTDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI+RLL + +EV+ A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRA  179
            ++    + +V R  ++ L+  ++  A+  L+++S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVAT  239
            +TLLGR+AG   VLSVGRVQTP L++VV+RD EI+NFV+K +F+V A +   +   F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WVPSEACEPYQDEEGRLLHRPLAEHVVKRI-EGQPALVTGYNDKRDSEPAPLPFSLSALQ  298
            WVP+     Y DEE R ++  +A +VV+   +   A +   +  R  ++APL+FSLS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADL  358
               +++ G +AQ VLDI QKLYETHKL TYPR+D  YLP         VL+A+    + L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PVMDPEIRNRCWDDKKVDAHHAIIPTARSSQV-KLTDNEAKVYHLIARQYLMQFCP  416
             P  + +D ++ +R W+DKK+ AHH+IIPT +++++ KL+D E +VY+L+  +YL QF P
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCE  476
            +  +   +  ++I+   F +++  L  +GW++L+G    D+E++     + A +   +C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  KGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLTKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQP  594
            L+KRGFL +  + + S+  GR L++ LP   + P++TA WE +L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVGTLFQLIDQARSTPV  611
                + QL+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  394 bits (1481),  Expect = 8e-111, Method: Compositional matrix adjust.
 Identities = 247/617 (41%), Positives = 398/617 (65%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYAR  60
            MRL + EKPS GR IA  L   +R G+G+++ G G  VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLTDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI+RLL + +EV+ A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRA  179
            ++    + +V R  ++ L+  ++  A+  L+++S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVAT  239
            +TLLGR+AG   VLSVGRVQTP L++VV+RD EI+NFV+K +F+V A +   +   F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WVPSEACEPYQDEEGRLLHRPLAEHVVKRI-EGQPALVTGYNDKRDSEPAPLPFSLSALQ  298
            WVP+     Y DEE R ++  +A +VV+   +   A +   +  R  ++APL+FSLS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADL  358
               +++ G +AQ VLDI QKLYETHKL TYPR+D  YLP         VL+A+    + L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PVMDPEIRNRCWDDKKVDAHHAIIPTARSSQV-KLTDNEAKVYHLIARQYLMQFCP  416
             P  + +D ++ +R W+DKK+ AHH+IIPT +++++ KL+D E +VY+L+  +YL QF P
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCE  476
            +  +   +  ++I+   F +++  L  +GW++L+G    D+E++     + A +   +C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  KGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLTKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQP  594
            L+KRGFL +  + + S+  GR L++ LP   + P++TA WE +L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVGTLFQLIDQARSTPV  611
                + QL+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  393 bits (1478),  Expect = 1e-110, Method: Compositional matrix adjust.
 Identities = 248/618 (41%), Positives = 408/618 (67%), Gaps = 25/618 (4%)

Query  1    MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDAYDPKF-K  59
            MRL + EKPS +R IA  L  + QRG+GF++ G    VTW  GHLLE AEP+ Y+ ++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLG-ATQRGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYA  119
             WR + LP++P++W+L+ + + K Q++V+++L+ Q D +V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRA  179
            ++    +++++R  +S L+ +++  A+  L P+    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNpeskeektpe  239
            +T+ GR++G + VLSVGRVQTP L+++V+RD EI++F +K +FEV A          T  
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIA----------TMA  224

Query  240  kstALFSALWQPSKACEDYQDDDGRVLSKGLAEKVVKRITNQP-AEVTEYKDVREKETAP  298
             +  LF++ W P+    +Y D++ R +  G+A +VV+   + P A + + +  R K++AP
Sbjct  225  VNGVLFPSKWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAP  281

Query  299  LPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLN  358
            L++SLS+LQ   +++ GM+AQ+VLD  Q+LYETH+L TYPR+DC YLP     E  +VL+
Sbjct  282  LAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLS  341

Query  359  AISTHCEAYQVLPNVILTEQRNRCWNDKKVEAHHAIIPTAKNRPVN-LTQEERNIYSLIA  417
            A+     A Q +   + T+  +R WNDKK+ AHH+IIPT     ++ L++ ERN+Y L+ 
Sbjct  342  AVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVR  401

Query  418  RQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGK---EDDTENQEPLLP  474
             +YL QF P+ E   +  T+NI+G  F +++  L  +GWK L+GK   +D+ +  E  LP
Sbjct  402  LHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLP  461

Query  475  IVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTE  534
             ++ GQ+ + + +E    +T+PP P+ D+TL++AMT  A FV D  LKK+L+E  G+GTE
Sbjct  462  AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTE  521

Query  535  ATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPNIATQPDMTAHWESQLTDISQKQ  594
            ATRAGII+ L+KRGFL +  + + ST  GR L++ LP   T+P++TA WE  L +++  +
Sbjct  522  ATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGR  581

Query  595  ATYQQFMHNLNQILPDLV  612
             + ++FM + +Q +++LV
Sbjct  582  VSLDDFMAKQSQWVSQLV  599

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  393 bits (1478),  Expect = 1e-110, Method: Compositional matrix adjust.
 Identities = 252/629 (41%), Positives = 395/629 (63%), Gaps = 20/629 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+  +GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++P+QW+L  ++ A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSQTKKAQTQRLLISDLNLPAVKRALNSLRSNRDFIPLSVSALARSRADWLYGMNMSRAY  181
            +    +++  RL +S L+ ++++ AL  L+++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIK  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV++ +F + A ++ +    P    
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFP----  231

Query  242  ARWKPSEA-CQPWQDEEGRVLSRKLVENVASRIANQP-ATVTESEHKQTKQAPPLPYSLS  299
            ++W P+   C    DEE R +   +  +V     + P A++ + +  + KQ++PL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+D  YLP     + + V  A+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELADAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQ  419
              L   V++ D  + S+ WND K+ AHH+IIPT   + ++ LS+ E ++YQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTG---ATEKEEDGADTVPPLAKGT  476
            F P      +   F+I+G +F ++G  L  +GWK+L G     + ++ G  T+P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGI  536
            V   + +  K  +T PP  + ++TL+ AMT  A +V+D  LKK+L+E  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ STP GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MAALQQRISELMQQVKTSPVPSSLRQLPP  625
            MA   Q++S+L+ Q ++ P+       PP
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  393 bits (1477),  Expect = 2e-110, Method: Compositional matrix adjust.
 Identities = 252/617 (41%), Positives = 401/617 (65%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDGRYAR  60
            MRL + EKPS GR IA  L   +R G+G+++ G G  VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGDAQEVIHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI+RLL + +EV+ A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLAPEKRQQVQRCLINDLNPQAVERAIARLRANSEFIPLCVSALARARADWLYGINMTRA  179
            ++    + +V R  ++ L+  ++  A+A L+++S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPKDERFVAT  239
            +TLLGR+AG   VLSVGRVQTP L++VV+RD EI+NFV+K +F+V A +   ++  F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WVPSDACEPYQDEEGRLLHRPLAEHVVARI-EGQPARVTAYNDKRDSEPAPLPFSLSTLQ  298
            WVP+     Y DEE R ++  +A +VV    +   A +   +  R  ++APL+FSLSTLQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADL  358
               +++ G +AQ VLDI QKLYETHKL TYPR+D  YLP         VL+A+    + L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PAVDPEIRNRCWDDKKVDAHHAIIPTARSSQV-KLSDNEEKVYGLIARQYLMQFCP  416
             P  +++D ++ +R W+DKK+ AHH+IIPT +++++ KLSD E +VY L+  +YL QF P
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKDDELLCE  476
            +  +   +  ++I+   F +++  L  +GW++L+G+   D+E++     + A +   +C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  KGEVVER--QTQPPRYFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLVKKGRYIHSTDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQP  594
            L+KRGFLV+  + + ST  GR L++ LP   + P++TA WE +L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVATLYQLIEQARSTPV  611
                + QL+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  393 bits (1477),  Expect = 2e-110, Method: Compositional matrix adjust.
 Identities = 252/629 (41%), Positives = 394/629 (63%), Gaps = 20/629 (3%)

Query  12   RLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERY-KK  70
            RL + EKPS GR IA  L   Q+  +GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  71   WNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCK  130
            W    LP++P+QW+L  ++ A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  131  LSQTKKAQTQRLLISDLNLPAVKRALNSLRSNRDFIPLSVSALARSRADWLYGMNMSRAY  190
            +    +++  RL +S L+ ++++ AL  L+++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  191  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIK  250
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV++ +F + A ++ +    P    
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFP----  231

Query  251  ARWKPSDA-CQPWQDEEGRVLSRKLVENVASRIANQP-ATVTESEHKQTKQAPPLPYSLS  308
            ++W P+   C    DEE R +   +  +V     + P A++ + +  + KQ++PL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  309  ALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNA  368
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+D  YLP     + + V  A+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  369  KELADAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQ  428
              L   V++ D  + S+ WND K+ AHH+IIPT   + ++ LS+ E ++YQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  429  FYPSATYAEAKLVFEIAGGVFIAKGRQLTFTGWKALSG---ATEKEEDGADTVPPLAKGT  485
            F P      +   F+I+G +F ++G  L   GWK+L G     + ++ G  T+P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  486  VLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGI  545
            V   + +  K  +T PP  + ++TL+ AMT  A +V+D  LKK+L+E  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  546  LDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPF  605
            +DTL+KR +L R+ K++ STP GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  606  MAALQQRISELMQQVKTSPVPSSLRQLPP  634
            MA   Q++S+L+ Q ++ P+       PP
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1476),  Expect = 2e-110, Method: Compositional matrix adjust.
 Identities = 252/629 (41%), Positives = 395/629 (63%), Gaps = 20/629 (3%)

Query  3    RLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERY-KK  61
            RL + EKPS GR IA  L   Q+  +GF+  G G  VTW  GHLLE  EP+ Y+E+Y K 
Sbjct  2    RLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  62   WNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCK  121
            W    LP++P+QW+L  ++ A  Q++VI +LLK+  EV+ A D+DREG+++  E+LDYCK
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  122  LSQTKKAQTQRLLISDLNLPAVKRALSSLRSNRDFVPLSVSALARSRADWLYGMNMSRAY  181
            +    +++  RL +S L+ ++++ AL+ L+++    +L  ++++RSRADWL GMN++R +
Sbjct  120  F----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLF  175

Query  182  TLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIK  241
            TLLG+ AG   VLSVGRVQTP L++VV+RD EI+NFV++ +F + A ++ +    P    
Sbjct  176  TLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFP----  231

Query  242  ARWKPSEA-CQPWQDEEGRVLSRKLVENVASRIANQP-ATVTESEHKQTKQAPPLPYSLS  299
            ++W P+   C    DEE R +   +  +V     + P A++ + +  + KQ++PL++SLS
Sbjct  232  SKWVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLS  287

Query  300  ALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNA  359
            +LQ   +++ GM+AQ VLD  Q LYE HKL TYPR+D  YLP     + + V  A+    
Sbjct  288  TLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTD  347

Query  360  KELSDAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQ  419
              L   V++ D  + S+ WND K+ AHH+IIPT   + ++ LS+ E ++YQL+  +YL Q
Sbjct  348  PALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQ  407

Query  420  FYPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTG---ATEKEEDGADTVPPLAKGT  476
            F P      +   F+I+G +F ++G  L  +GWK+L G     + ++ G  T+P++  G 
Sbjct  408  FLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ  467

Query  477  VLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGI  536
            V   + +  K  +T PP  + ++TL+ AMT  A +V+D  LKK+L+E  G+GTEATRAGI
Sbjct  468  VCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGI  527

Query  537  LDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPF  596
            +DTL+KR +L R+ K++ STP GR L++ LP   T P++TA WE+ L+ +A    + + F
Sbjct  528  IDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDF  587

Query  597  MAALQQRISELMQQVTTSPVPSSLRQLPP  625
            MA   Q++S+L+ Q  + P+       PP
Sbjct  588  MAKQSQWVSQLVAQGRSQPLTMQAPPSPP  616

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1474),  Expect = 3e-110, Method: Compositional matrix adjust.
 Identities = 246/612 (41%), Positives = 391/612 (64%), Gaps = 15/612 (2%)

Query  1    MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGEQDMVTWCVGHLLEQAQPDVYDARYAR  60
            MRL + EKPS +R IA  L   +R G+GF+  G    VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WSLADLPIVPQKWLLQPRPSVSKQLNVIKKLLTQADEVIHAGDPDREGQLLVDEVLEYL  119
             W    LP++PQ+W L  ++    Q+ VI++LL Q DEV+ A D+DREG+++  E+L+Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  ALPEAKRQQVRRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRA  179
             +      +V R  ++ L+  ++  A++ L+ +    +L  ++++RSRADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGKNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVSRDYFEVKAHIVTANERFIALW  239
            +TLLG++AG   VLSVGRVQTP L++VV+RD EIDNFVS+ YFEV A +      F + W
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKW  234

Query  240  QPSDSCEPYQDEEGRLLHRPLAEHVVKRI-EGQPAQVTAYNDKRESETAPLPYSLSTLQI  298
             P+     Y DEE R ++  +A +VV+   +   A +   +  R  ++APL++SLSTLQ 
Sbjct  235  VPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  299  ETAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIAAHQPDLL  358
              +++ G++AQ VLDI Q+LYETHKL TYPR+DC YLP         VL+A+ + +P L 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  359  PQPAA-DPERRNRCWDDSKVDAHHAIIPTARSAR-TSLTEQESQVYGLIARQYLMQFCAD  416
            P  A+ D +  +R W+D K+ AHH+IIPT +++  + L++ E +VY L+  +YL QF ++
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  417  AVFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGHKERDEENEGMPLPVVAKGDELLCER  476
              +      ++I+G  F +++  L  +GW++L+G    D+E++     + A     +C+ 
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQV  471

Query  477  GEVVER--QTQPPRPFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELL  534
                ++  QT+PP P+ D+TL++AMT  A FV D ALKK+L+E  G+GTEATRAGII+ L
Sbjct  472  QGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTL  531

Query  535  FKRAFLIKKGRHIHATDAGKALIHALPPIAAHPDMTAHWEATLTQISEKRCRYQDFMQPL  594
            +KR+FL++  + + +T  G+ L++ LP   ++P++TA WE  L +++  R   +DFM   
Sbjct  532  LKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQ  591

Query  595  TQSLYELIQQAR  606
            +Q + +L+ Q+R
Sbjct  592  SQWVSQLVAQGR  603

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1474),  Expect = 3e-110, Method: Compositional matrix adjust.
 Identities = 249/617 (41%), Positives = 399/617 (65%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDGRYAR  60
            MRL + EKPS GR IA  L   +R G+GF++ G G  VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVVHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI+RLL + +EVV A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRA  179
            ++    + +V R  ++ L+  ++  A+  L+++S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQDERFIAT  239
            +T+LGR+AG   VLSVGRVQTP L++VV+RD EI+NFV+K +F+V A +   ++  F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WVPSEACEPYQDEEGRLLHRPLAEHVVKRI-EGQPAIVTGYNDKRDSEPAPLPFSLSALQ  298
            WVP+     Y DEE R ++  +A +VV+   +   A +   +  R  ++APL+FSLS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHAPDL  358
               +++ G +AQ VLDI QKLYETHKL TYPR+D  YLP         VL+A+    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PVMDPEIRNRCWDDKKVDAHHAIIPTARSSQV-KLNDNEEKVYNLIARQYLMQFCP  416
             P  + +D ++ +R W+DKK+ AHH+IIPT +++++ KL+D E +VY+L+  +YL QF P
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKGDELLCE  476
            +  +   +  ++I+   F +++  L  +GW++L+G+   D+E++     + A     +C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  KGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLNKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQP  594
            L+KRGFL +  + + S+  GR L++ LP   + P++TA WE +L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVGTLFQLIDQARSTPV  611
                + QL+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1473),  Expect = 4e-110, Method: Compositional matrix adjust.
 Identities = 242/590 (42%), Positives = 382/590 (65%), Gaps = 9/590 (1%)

Query  1    MRLIIAEKPSLARAIANALPASPRREEGALVAGDTVVTWCLGHLLEQAPPDAYDPAL-KT  59
            MRL++ EKPS +R IA+ L ++ +R EG L + +  VTW  GHLLE A P+ Y+    K 
Sbjct  1    MRLVLCEKPSQGRDIAKFL-GATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKP  59

Query  60   WRLDSLPILPDHWKLMPRPKARGQLAVIRRLLKSADQVVHAGDPDREGQLLVQEVIEHLG  119
            WR D LP+LP++WKL+ ++ A++Q+AVI RLLK  D+VV A D+DREG+++ +E+++   
Sbjct  60   WRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCK  119

Query  120  WKRDVARLLVSDLNPPAVKRALERLEDNRRYASLYRAAQARARADWLYGINLTRAWTLVG  179
             +  V RL +S L+ ++++ AL  L  + R  SLY A+ +R+RADWL G+NLTR  TL+G
Sbjct  120  FQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLG  179

Query  180  RQAGHDGVLSVGRVQTPVLGLVVRRDAEIRDFEPRPFFVLWVDLVVSRGQLRAWWVPGDT  239
            R+AG + VLSVGRVQTP L++VV+RD EI +F ++P+F +   + V+   + + WVP+  
Sbjct  180  REAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQ  239

Query  240  HRLDDQgrlldrapaaaladrlpgaEGRLDSLASRDKRQAAPLPYSLSALQVDAARRHGL  299
               +++  +    +A  +      + + + +     K+Q+APL++SLS+LQ   +R+ G+
Sbjct  240  YCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGM  299

Query  300  SAKAVLDVCQRLYERHQLITYPRSDCRYLPEEHFAQAQRTLSGACRNDETLSRWLAGADF  359
            +A++VLD+ Q+LYE H+L TYPR+DC YLP     +  + LS+    D +L   +A+ D 
Sbjct  300  PAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDT  359

Query  360  SRRSKAWDDKKVGAHHALAPTGKPADLDRLSRQEADVFRLIARNVLAQFYPALQTREVKA  419
               S+ W+DKK+ AHH++ PT   +DL +LS  E +V++L+  + LAQF P ++     A
Sbjct  360  QFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEA  419

Query  420  EFLIAGERFRARGQEVLEPGWKPLFTTRDEA-------PPLPPLSEGEACRVEQAGVEDR  472
             F I+G+ FR+RG+ ++ PGWK+LF    E          LP++  G+ C+V+ A     
Sbjct  420  TFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVL  479

Query  473  ETRPPEHFTDASLIKAMMNIARYVDDPAIRRTLRDSDGLGTEATRAGIIETLLERGYLVR  532
            +T+PP  + D++LI AM N A +V D+A+++ L+++ G+GTEATRAGII+TLL RG+LVR
Sbjct  480  QTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR  539

Query  533  EGKSLKASRLGSALIASLPEAVGRPERTAQWEQRLANIAEQDDAPAPFLE  582
            E K+LK++ LG  L+  LP ++  P  TA WEQ L ++A    +   F+ 
Sbjct  540  EKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1473),  Expect = 4e-110, Method: Compositional matrix adjust.
 Identities = 269/672 (41%), Positives = 415/672 (62%), Gaps = 35/672 (5%)

Query  1    MRLFIAEKPSVAKAIASELGQSGKGDGFIECGTDTVTWCFGHMLEQAEPDEYTPDDVPRN  60
            MRL + EKPS ++ IA  LG + +G+GF++    TVTW  GH+LE AEP+ Y        
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVY-------G  53

Query  61   ARGKKIWRVDELPIIPTDWMLKAKDDAKQQLAVIGKLLKEAAEIVNAADPDREGQLLVDE  120
             +  K WR D LP++P +W L  K DAK Q+AVI +LLK+  E+V A+D+DREG+++  E
Sbjct  54   EQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARE  113

Query  121  VLEHFRCNKPAR--RFWVSAQDSVSVKRGLAAL----KDNGTYHGWadaararqradWLI  174
            +L+   C+  +R  R+W+SA D  S++ +LA L    + ++ Y +    + +R RADWLI
Sbjct  114  LLDY--CKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYA----GVGRSRADWLI  167

Query  175  GMNLSRAYTLRAQRGGSRGLLTVGRVQTPTLTLVVARDREIEAFKPIPYHTIRAAIQHSG  234
            GMNL+R +TL ++ +G   +L+VGRVQTPTL++VV RDREI+ F + PY  + A++  +G
Sbjct  168  GMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG  227

Query  235  GAFLASWRAKVDQAGLDAEGRlvdtavadalvakvtGKP-GTVAEYTQEAKKQNQPLAFA  293
              F + W +  +    D E R ++++VA  +V      P +++ +   E KKQ+ PLAF+
Sbjct  228  VLFPSKWVPAAQYC--DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFS  285

Query  294  LSDITLLASNKFGYSAEDVLNACQTLYETHKLTSYPRTDCAYLPESQHADSPRVLKAIQH  353
            LS +    S   G +A+ VL+  Q LYETHKLT+YPRTDC+YLP S + + P+VL A+  
Sbjct  286  LSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVG  345

Query  354  VNPELAGLVAGADPRLKSKTWNDSKITAHHGIIPTMHNGSKAGLIERERNIYDLIVRAYL  413
             +P L  +VA+ D ++ S+ WND KITAHHGIIPT H G  + L + ERN+Y+L+   YL
Sbjct  346  TDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYL  405

Query  414  AQFYCVHEYMSttvvvevedetfvATGKVVTRNGWRDVYQEVDEQDTEKDADEGGNQRLP  473
            AQF    E   T    ++ ++ F + G+V+ + GW+ ++  + E+    D D+ G+  LP
Sbjct  406  AQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSED----DEDNTGETTLP  461

Query  474  AMQKGDGVTCKQATRKDAKTKPPARFTEGTLLRAMENIHKVVPEPEHKKMLREEDGIGTS  533
            AMQ G+    + A +K  +TKPPA + +GTL+ AM N    V ++  KK+L+E+ GIGT 
Sbjct  462  AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTE  521

Query  534  ATRASIISELKRRGFLETKGKQIIGTTLGRSMIDALPEVVKSPVLTALYERMLKGIEQGT  593
            ATRA+II  L +RGFL    K + +T LGR+++D LP  + +P LTAL E+ML  +  G 
Sbjct  522  ATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGR  581

Query  594  AELAAFIAKQETFIRDQVTKANDGAVAIAGGREALPISTLYKCMACGQGLIRRPTKKADV  653
              L  F+AKQ   + + V+++   ++++ +   +        C  CG   ++R   K+++
Sbjct  582  VSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSP-------PCPVCGGKTLQRNG-KSGL  633

Query  654  FWWACSNFPTCK  665
            F W+C ++P CK
Sbjct  634  F-WGCLKYPECK  644

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1473),  Expect = 4e-110, Method: Compositional matrix adjust.
 Identities = 249/617 (41%), Positives = 399/617 (65%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDGRYAR  60
            MRL + EKPS GR IA  L   +R G+GF++ G G  VTW  GHLLE A+P+VY+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVVHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI+RLL + +EVV A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRA  179
            ++    + +V R  ++ L+  ++  A+  L+++S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQDERFIAT  239
            +T+LGR+AG   VLSVGRVQTP L++VV+RD EI+NFV+K +F+V A +   ++  F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WVPSEACEPYQDEEGRLLHRPLAEHVVKRI-EGQPAIVTGYNDKRDSEPAPLPFSLSALQ  298
            WVP+     Y DEE R ++  +A +VV+   +   A +   +  R  ++APL+FSLS+LQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHAPDL  358
               +++ G +AQ VLDI QKLYETHKL TYPR+D  YLP         VL+A+    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PVMDPEIRNRCWDDKKVDAHHAIIPTARSSQV-KLNDNEEKVYNLIARQYLMQFCP  416
             P  + +D ++ +R W+DKK+ AHH+IIPT +++++ KL+D E +VY+L+  +YL QF P
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKGDELLCE  476
            +  +   +  ++I+   F +++  L  +GW++L+G+   D+E++     + A     +C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  KGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLNKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQP  594
            L+KRGFL +  + + S+  GR L++ LP   + P++TA WE +L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVGTLFQLIDQARSTPV  611
                + QL+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  392 bits (1473),  Expect = 4e-110, Method: Compositional matrix adjust.
 Identities = 238/592 (41%), Positives = 393/592 (67%), Gaps = 12/592 (2%)

Query  7    KKSDGFITAGNGDVVTWCIGHLLEQAEPEAYNPDY-KKWAVEHLPIVPNEWKLVVKSKTR  65
            ++++GF+  G G  VTW  GHLLE AEPE Y  +Y K W  + LP++P++WKLVVK+ ++
Sbjct  23   QRGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAK  81

Query  66   KQFTVVKTLIKKADTLVNMGDPDRVGQILIDEVINHCGVSKAKKTQVLRCLISDLNPAAV  125
             QF+V++ L+K+ D +V   D+DR G+++  E+++ C      + +V+R  +S L+ A++
Sbjct  82   AQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF----QGRVFRLWMSALDDASI  137

Query  126  KKALNNLRKNTDFIPLATSALARARADWLYGINMTRLCTLQGRQSGYNGVLSIGRVQTPV  185
            + AL +L+ ++   +L  ++++R+RADWL G+N+TRL TL GR++G   VLS+GRVQTP 
Sbjct  138  RSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPT  197

Query  186  LGLIVHRDLEIANFVSKPFYEVICTLLTSKGEAYQAKWRPSKACEPYMDEDNRVLSKPLA  245
            L+++V RD EI NFVSKP++EVI T+ + +G  + +KW P+     Y DE++R +   +A
Sbjct  198  LAIVVKRDREIDNFVSKPYFEVIATM-AVNGVLFPSKWVPA---AQYCDEEKRCIQSGVA  253

Query  246  LNVISKV-QNKAGKVVNVTQAKKATPPPLPYSLSALQIDAAKRFGMSAQSVLDTCQQLYE  304
             +V+    Q  ++ ++N    +K  ++PL++SLS+LQ   +++ GM+AQ+VLD  Q+LYE
Sbjct  254  AQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYE  313

Query  305  RHKLITYPRSDCRYLPKEHLNDVKQVVGAIGKSCsalsdaannanlslknkawnDSKVSA  364
             HKL TYPR+DC YLP    +++ QV++A+  + +AL     + +  + ++ WND K++A
Sbjct  314  THKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITA  373

Query  365  HHAIIPTSKSTDLSRLSPAENNIYELVARQYLIQFYPPFEYVDKQIDTEVSGGLFISKQK  424
            HH+IIPT  + DLS+LS AE N+Y+LV  +YL QF P  E    +   +++G LF ++ +
Sbjct  374  HHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGN  433

Query  425  DVVSQGWKALFPSKQKSQAESEFSAVSLPNVSKGDEVHCQQADLIEKQTTPPKYFTDATL  484
             +V  GWK+LF +K   + E + +  +LP +  G+  + Q A+    QT PP  + D+TL
Sbjct  434  VLVKPGWKSLF-GKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTL  492

Query  485  LSAMTGIARYVTDASIKKVLRDTDGLGTEATRAGIIELLFKRQFLTRKGKDIRATDVGTQ  544
            ++AMT  A +VTDA++KKVL++  G+GTEATRAGII+ L+KR FL R  K +++T +G +
Sbjct  493  IAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRN  552

Query  545  LICSLPERMTIPDMTAHWESQLEAISQKEIKYAHFMDPITQSIDTLIAEVKT  596
            L+  LP  +T P++TA WE  L+ ++   +   +FM   +Q +  L+A+ ++
Sbjct  553  LVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRS  604

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  391 bits (1470),  Expect = 7e-110, Method: Compositional matrix adjust.
 Identities = 252/616 (41%), Positives = 405/616 (66%), Gaps = 25/616 (4%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGNDDVVTWCVGHLLEQAEPDAYDPKF-K  59
            MRL + EKPS GR IA  L  + QRG+GF++ G +  VTW  GHLLE AEP+ Y+ ++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLG-ATQRGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRLEHLPIIPEKWILLPRKEVKKQLSVVEKLIHQADVLVNAGDPDREGQLLVDEVFSYA  119
             WR + LP++P++W L+ + + K Q++V+++L+ Q D +V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAEKRDGILRCLISDLNPSAVEKAVQKLQPNRNFIPLATSALARARADWLYGINMTRA  179
            ++ +     ++R  +S L+ +++  A+  L P+    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQGR----VFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIRGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFYEVLAWVKEEKTSENPTA  239
            +T+ GR+AG + VLSVGRVQTP L+++V+RD EI+NF +K ++EV+A      T      
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIA------TMAVNGV  228

Query  240  LFSALWQPSKACEDYQDEDGRVLSLGLAENVVKRITDQP-AEVTEYVDKREKETAPLPYS  298
            LF++ W P+    +Y DE+ R +  G+A +VV+   + P A + +    R K++APL++S
Sbjct  229  LFPSKWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFS  285

Query  299  LSALQIDAAKRFGMSAQSVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHKVMNAISQ  358
            LS+LQ   +++ GM+AQ+VLD  Q+LYETH+L TYPR+DC YLP     E  +V++A+  
Sbjct  286  LSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVG  345

Query  359  HCQTYQTLPLVVDTEQRNRCWNDKKVEAHHAIIPTANTRSIN-LSIDEQRIYELIARQYL  417
               + Q +   +DT+  +R WNDKK+ AHH+IIPT +T  ++ LS  E+ +Y+L+  +YL
Sbjct  346  TDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYL  405

Query  418  LQFCPDAEYRKSKIILSIAGGTFVAQARNLQTAGWKELLGK---EDEDENQEPLLPIVKK  474
             QF P+ E   +   ++I+G  F +++  L  +GWK L+GK   +DED+  E  LP ++ 
Sbjct  406  AQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQA  465

Query  475  GQILYCERGEVVSK--KTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEAT  532
            GQ+  C+      K  +T+PP P+ D+TL++AMT  A FV D  LKK+L+E  G+GTEAT
Sbjct  466  GQV--CQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEAT  523

Query  533  RAGIIELLFKRGFLTKKGRNIHSTETGRILISALPDIATQPDMTAHWEAQLTDISQKQAS  592
            RAGII+ L+KRGFL +  + + ST  GR L+  LP+  T+P++TA WE  L +++  + S
Sbjct  524  RAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVS  583

Query  593  YQQFMFTLNQMLPDLV  608
             ++FM   +Q +++LV
Sbjct  584  LDDFMAKQSQWVSQLV  599

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1467),  Expect = 1e-109, Method: Compositional matrix adjust.
 Identities = 249/617 (41%), Positives = 394/617 (64%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGR  60
            MRL + EKPS GR IA  L   +R G+GF++ G G  VTW  GHLLE A+P+ Y+ +YG+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI++LL++ +E+V A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRA  179
            ++ +    +V R  ++ L+  ++  A+  L+ +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAQERFTAL  239
            +TLLG++AG   VLSVGRVQTP L++VV+RD EI+NFV+K +FEV A +   +   F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG-VLFPSK  233

Query  240  WQPSEACEPYQDEEGRLLNRALAEHVVKRI-EGQPAVVTSYNDKRESEAAPLPFSLSTLQ  298
            W P+     Y DEE R ++ ++A +VV+   +   A + + +  R  ++APL+FSLSTLQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAARRFNLSAQTVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHAPDL  358
               +R+  ++AQTVLDI QKLYETHKL TYPR+DC YLP         VL A+    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PAVDPERRNRCWDDKKVDAHHAIIPTARSAP-ASLSDGEAKIYGLIARQYLMQFCQ  416
             P  +++D +  +R W+DKK+ AHH+IIPT +++  + LSD+E ++Y L+  +YL QF  
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAQFRKCVIELEIAGGKFIAKARFLAETGWRALLGAKERDEENDGTPLPVVAKGDELHCE  476
            + ++      ++I+G  F +++  L   GW++L+G    D+E++     + A      C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  HGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQP  594
            L+KRGFL ++ + + STP G+ L++ LP   + P++TA WE  L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVQTLYTLIDQARSAPV  611
              Q +  L+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1466),  Expect = 1e-109, Method: Compositional matrix adjust.
 Identities = 249/617 (41%), Positives = 394/617 (64%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGR  60
            MRL + EKPS GR IA  L   +R G+GF++ G G  VTW  GHLLE A+P+ Y+ +YG+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI++LL++ +E+V A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRA  179
            ++ +    +V R  ++ L+  ++  A+  L+ +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAQERFTAL  239
            +TLLG++AG   VLSVGRVQTP L++VV+RD EI+NFV+K +FEV A +   +   F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG-VLFPSK  233

Query  240  WQPSEACEPYQDEEGRLLNRALAEHVVKRI-EGQPAVVTSYNDKRESEAAPLPFSLSTLQ  298
            W P+     Y DEE R ++ ++A +VV+   +   A + + +  R  ++APL+FSLSTLQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAARRFNLSAQTVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHAPDL  358
               +R+  ++AQTVLDI QKLYETHKL TYPR+DC YLP         VL A+    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PAVDPERRNRCWDDKKVDAHHAIIPTARSAP-ASLSDGEAKIYGLIARQYLMQFCQ  416
             P  +++D +  +R W+DKK+ AHH+IIPT +++  + LSD+E ++Y L+  +YL QF  
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAQFRKCVIELEIAGGKFIAKARFLAETGWRALLGAKERDEENDGTPLPVVAKGDELHCE  476
            + ++      ++I+G  F +++  L   GW++L+G    D+E++     + A      C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  RGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQP  594
            L+KRGFL ++ + + STP G+ L++ LP   + P++TA WE  L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVQTLYSLIDQARSAPV  611
              Q +  L+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1467),  Expect = 1e-109, Method: Compositional matrix adjust.
 Identities = 249/617 (41%), Positives = 394/617 (64%), Gaps = 16/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGR  60
            MRL + EKPS GR IA  L   +R G+GF++ G G  VTW  GHLLE A+P+ Y+ +YG+
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYL  119
             W    LP++P++W+L  K+    Q+ VI++LL++ +E+V A D+DREG+++  E+LDY 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  QLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRA  179
            ++ +    +V R  ++ L+  ++  A+  L+ +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPAQERFTAL  239
            +TLLG++AG   VLSVGRVQTP L++VV+RD EI+NFV+K +FEV A +   +   F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG-VLFPSK  233

Query  240  WQPSEACEPYQDEEGRLLNRALAEHVVKRI-EGQPAVVTSYNDKRESEAAPLPFSLSTLQ  298
            W P+     Y DEE R ++ ++A +VV+   +   A + + +  R  ++APL+FSLSTLQ
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQ  290

Query  299  IEAARRFNLSAQTVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHAPDL  358
               +R+  ++AQTVLDI QKLYETHKL TYPR+DC YLP         VL A+    P L
Sbjct  291  QACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPAL  350

Query  359  LPQ-PAVDPERRNRCWDDKKVDAHHAIIPTARSAP-ASLSDGEAKIYGLIARQYLMQFCQ  416
             P  +++D +  +R W+DKK+ AHH+IIPT +++  + LSD+E ++Y L+  +YL QF  
Sbjct  351  QPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLP  410

Query  417  DAQFRKCVIELEIAGGKFIAKARFLAETGWRALLGAKERDEENDGTPLPVVAKGDELHCE  476
            + ++      ++I+G  F +++  L   GW++L+G    D+E++     + A      C+
Sbjct  411  QMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQ  470

Query  477  HGEVVER--QTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIEL  534
                 ++  QT+PP  + D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+ 
Sbjct  471  VQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDT  530

Query  535  LFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQP  594
            L+KRGFL ++ + + STP G+ L++ LP   + P++TA WE  L +++  +   +DFM  
Sbjct  531  LLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAK  590

Query  595  LVQTLYTLIDQARSAPV  611
              Q +  L+ Q+RS P+
Sbjct  591  QSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1465),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 247/617 (41%), Positives = 395/617 (65%), Gaps = 32/617 (5%)

Query  1    MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEF-K  59
            M L + EKPS GR IA  L   ++ G+GF++++    V+W  GHLLE AEP+ Y  ++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLNGPGVT-VTWARGHLLETAEPEVYGEQYGK  58

Query  60   SWKFEHLPIVPDKWQLKPKAATRSQLTVLKRLVKQANTLVNAGDPDREGQLLVDEVIAYL  119
            +W+ + LP++P++W+L  KA +++Q++V++RL+KQ + +V A D+DREG+++  E++ Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRA  179
               G  +    RL +S L+  +++ AL++L+++    +L  ++++RSRADWL GMN+TR 
Sbjct  119  KFQGRVF----RLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFQSKPFYEVLAHLATEKQEAFSAK  239
            +T+ G+  G   VLSVGRVQTP L++VV+RD EI NF SKP++EV+A +A +    F++K
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVN-GVLFPSK  233

Query  240  WQPSEACQPYMDEEGRVLARGLAQNVV--SRISDKPALVTQLVAKDKKQNPPLPYSLSAL  297
            W P+     Y DEE R +  G+A +VV   R +  +A++   + + KKQ++PL++SLS+L
Sbjct  234  WVPAA---QYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIER-KKQSAPLAFSLSTL  289

Query  298  QIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHSLAPSVLKAISGGAAE  357
            Q   +++ GM+A+ VLD  Q LYE HKL TYPR+D  YLP+  +   P VL A+ G  + 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  358  LLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHVARQYLAQFY  417
            L     + D ++ S+ W+DKK+ AHH+I+PT  T++LS LS+ ER++Y  V  +YLAQF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESAGKDDE  477
            P      T     I G LF T++      GWK LF++   ++   +G+ +          
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETT----------  459

Query  478  ENDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLGAMTGISRYVTDPEIRKI  537
                    LP+++ GQ  +   +E    +T+PP ++ D+TL++AMT  + +VTD+ ++K+
Sbjct  460  --------LPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKV  511

Query  538  LKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPASATTPDMTALWE  597
            LKE  G+GTEATRAGII+ L+KRGFL R  K++ ST +G+ L++ LP++ T P++TALWE
Sbjct  512  LKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWE  571

Query  598  ASLNGICHKETSYQAFM  614
              L+ +     S + FM
Sbjct  572  QMLDEVAAGRVSLDDFM  588

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1468),  Expect = 9e-110, Method: Compositional matrix adjust.
 Identities = 253/617 (42%), Positives = 398/617 (65%), Gaps = 18/617 (2%)

Query  1    MRLFIAEKPSLARAIADVLPKPHKRGDGFIVCGDNQYVTWCVGHLLEQAEPDAYDPRYAR  60
            MRL + EKPS +R IA  L   + RG+GF+  G    VTW  GHLLE AEP+ Y+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WSLDDLPIIPNKWQLKPRADVKKQLDTINTLLKQADEVIHAGDPDREGQLLVDEVLNYL  119
             W  D LP++P++W+L  +AD K Q+  IN LLKQ DEV+ A D+DREG+++  E+L+Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NISDAQRKQARRCLINDLNPAAVSRAIDKLRYNHEFIPLCVSALARARADWLYGINMTRA  179
            ++ +    +  R  ++ L+ A++  A+  L+ +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGQRNGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPADERFTAI  239
            +TLLG+  G   VLSVGRVQTP L++VV+RD EI+NFV+K +FEV A +    +  F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WQPSEH-CEPWQDEEGRLLHRKLAEHVVDRIAGKP-ANVTDYQDKQESEIAPLPFSLSAL  297
            W P+ + C    DEE R ++  +A +VV+     P A + + Q  +  + APL+FSLS+L
Sbjct  234  WVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  298  QIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVMNAISVHDNS  357
            Q   +++ G++AQ VLD  Q+LYETHKL TYPR+D  YLP         V++A+   D +
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  358  LLPQ-ETLDIDKKNRCWDDKKVDAHHAIIPTAKTGNIS-LSENEKNIYYLIARQYLMQFM  415
            L P   +LD +  +R W+DKK+ AHH+IIPT  TG++S LS+ E+N+Y L+  +YL QF+
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  416  PDAVYRKCVIELDIENGKFIAKARFLAQAGWRTLLGSKEQDAENDGSALPIVAKGDELLC  475
            P+         ++I    F +++  L ++GW++L+G   +D E++ +   + A     +C
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  476  EKGEIVAK--QTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIE  533
            +      K  QT+PP P+ D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  534  LLFKRGFLQKKGRAINSTPAGRALIHVLPDMATLPDMTAHWESILTQISEKQFKYQDFMM  593
             L+KRGFL +  ++++STP GR L++VLP+  T P++TA WE +L +++  +   +DFM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  594  PLSNTLFELITQAKRRP  610
              S+ + +L++Q++ +P
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  390 bits (1468),  Expect = 9e-110, Method: Compositional matrix adjust.
 Identities = 253/617 (42%), Positives = 398/617 (65%), Gaps = 18/617 (2%)

Query  1    MRLFIAEKPSLARAIADVLPKPHKRGDGFIVCGDNQYVTWCVGHLLEQAEPDAYDPRYAR  60
            MRL + EKPS +R IA  L   + RG+GF+  G    VTW  GHLLE AEP+ Y+ +Y++
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  61   -WSLDDLPIIPNKWQLKPRADVKKQLDTINTLLKQADEVIHAGDPDREGQLLVDEVLNYL  119
             W  D LP++P++W+L  +AD K Q+  IN LLKQ DEV+ A D+DREG+++  E+L+Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NISDAQRKQARRCLINDLNPAAVSRAIDKLRYNHEFIPLCVSALARARADWLYGINMTRA  179
            ++ +    +  R  ++ L+ A++  A+  L+ +    +L  ++++R+RADWL G+N+TR 
Sbjct  119  KFQG----RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLLGQRNGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPADERFTAI  239
            +TLLG+  G   VLSVGRVQTP L++VV+RD EI+NFV+K +FEV A +    +  F + 
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAV-NGVLFPSK  233

Query  240  WQPSEH-CEPWQDEEGRLLHRKLAEHVVDRIAGKP-ANVTDYQDKQESEIAPLPFSLSAL  297
            W P+ + C    DEE R ++  +A +VV+     P A + + Q  +  + APL+FSLS+L
Sbjct  234  WVPAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  298  QIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVMNAISVHDNS  357
            Q   +++ G++AQ VLD  Q+LYETHKL TYPR+D  YLP         V++A+   D +
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  358  LLPQ-ETLDIDKKNRCWDDKKVDAHHAIIPTAKTGNIS-LSENEKNIYYLIARQYLMQFM  415
            L P   +LD +  +R W+DKK+ AHH+IIPT  TG++S LS+ E+N+Y L+  +YL QF+
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  416  PDAVYRKCVIELDIENGKFIAKARFLAQAGWRTLLGSKEQDAENDGSALPIVAKGDELLC  475
            P+         ++I    F +++  L ++GW++L+G   +D E++ +   + A     +C
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  476  EKGEIVAK--QTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIE  533
            +      K  QT+PP P+ D+TL++AMT  A FV D  LKK+L+   G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  534  LLFKRGFLQKKGRAINSTPAGRALIHVLPDMATLPDMTAHWESILTQISEKQFKYQDFMM  593
             L+KRGFL +  ++++STP GR L++VLP+  T P++TA WE +L +++  +   +DFM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  594  PLSNTLFELITQAKRRP  610
              S+ + +L++Q++ +P
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  389 bits (1463),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 264/617 (43%), Positives = 424/617 (69%), Gaps = 18/617 (2%)

Query  1    MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAAGDVVTWCIGHLLEQAEPDAYDAAF-K  59
            MRL + EKPS GR IA  L   ++ G+GF++ ++G  VTW  GHLLE AEP+ Y+  + K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   QWRMEQLPIIPAQWQLVAKPKTKTQLTVIKRLIKLADCVVNAGDPDREGQLLVDEVIDFL  119
             WR + LP++P QW+LV K+ +K+Q++VI+RL+K  D VV A D+DREG+++  E++D+ 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  GYPKTRPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYT  179
             +     V R  +S L+ +++R AL  L+ +    +L  ++++RSRADWL G+N+TR +T
Sbjct  119  KFQG--RVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFT  176

Query  180  LLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLVTDGNERFSAKWL  239
            LLGR +G +++LSVGRVQTP L++VV+RD EI+ FV+KP++EV+A +  +G   F++KW+
Sbjct  177  LLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGV-LFPSKWV  235

Query  240  PSEA-CLPWQDEEGRVLNRALAEKVVSRINGQP-ASVEEVEEQARKQAAPLPYNLSSLQI  297
            P+   C    DEE R ++ ++A +VV      P A++ + + + +KQ+APL+++LS+LQ 
Sbjct  236  PAAQYC----DEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQ  291

Query  298  DAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSEHFNRAAQVREaiaatapala  357
              +++ GM A+ VLD+ Q LYE HKL TYPR+D   LP    +  +QV  A+ +T PAL 
Sbjct  292  ACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQ  351

Query  358  raVSEADGKIRSKAWNDSKVDAHHAIIPTEKRGNESSLSGDEAKIYGLVARQYLLQFYPP  417
              V+  D ++ S+ WND K+ AHH+IIPT   G+ S LS+ E ++Y LV  +YL QF P 
Sbjct  352  PVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQ  411

Query  418  FEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAG--TLPALKEGEQLLC  475
             E + +   + I+G LF++++  ++K+GWK+L+G   +DDE+++G  TLPA++ G+  +C
Sbjct  412  MEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQ--VC  469

Query  476  ERGELLEKM--TQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIID  533
            +     +K+  T++P ++ D+TL+AAMT  A +V D+ ++K L+E  G+GTEATRAGIID
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  534  LLFRRRFLVRQGKSIKGTPTGRalilalpttattpdmtalWEQSLGQIAERHASYQQFMG  593
             L++R FLVR+ K++K+TP GR L+  LP T T P++TALWEQ L+++A  + S ++FM+
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  594  PLTDQLNALIEGARQDS  610
              ++ ++ L+  +R ++
Sbjct  590  KQSQWVSQLVAQGRSQP  606

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  389 bits (1464),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 254/618 (42%), Positives = 409/618 (67%), Gaps = 17/618 (2%)

Query  1    MRLFVAEKPSLARAIADVLPKPHTKGDGFIQCGEHDTVTWCIGHLLEQAEPDVYDERF-K  59
            MRL + EKPS +R IA  L   + +G+GF++ G   TVTW  GHLLE AEP+VY+E++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   MWRMEHLPIVPEQWKLIPKKETLKQFKVVEKLIKKADVLVNAGDPDREGQLLVDEVFGYL  119
             WR + LP++P+QWKL+ K ++  QF V+++L+K+ D +V A D+DREG+++  E+++Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAERKSQIQRCLVSDLNPNAVSRAIEKLQKNSDFIPLATSALARARADWLYGINMTRA  179
            ++    ++++ R  +S L+  ++  A+  L  +S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDYFEVLAQIVVPETQERFKA  239
            +TL GR AG   VLSVGRVQTP L+++V+RD EI++FV+K YFEV+A + V      F +
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL--FPS  232

Query  240  QWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQP-ATVTEYQNKIEKETAPLPYSLSVL  298
            +W P+    +Y DE+ R +   +A +VV+   + P A++ + Q    K++APL++SLS L
Sbjct  233  KWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  299  QMEAAGRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPTEHFNDRFKVMAAIAHHLPE  358
            Q   + + G++AQ+VLDI QKLYETHKL TYPR+D  YLP    ++  +V++A+    P 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  359  YQQKPEVIDATIRNRCWNDKEVEAHHAIIPTARQGTV-HLTENEKRVYQLIARQYLMQFC  417
             Q     +D+ + +R WNDK + AHH+IIPT + G +  L++ E+ VYQL+  +YL QF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PDAEYRKSKIGLEIAGGSFVAQARNLVIAGWRALLGK---EDSLDDAEPLLPIVKKGQIL  474
            P+ E   +   ++I+G  F +++  LV +GW++L+GK   +D  + +E  LP ++ GQ+ 
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  475  HCEKGEIVSKKTQPPRHFTDRSLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIE  534
            + + +E    +T+PP  + D +L++AMT  A FV D  LKK+L+E  G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  535  LLFKRGFLIRKGKNIHSTEAGRILIQALPDSATQPDMTAHWEMQLNQISKKETSYQQFMF  594
             L+KRGFL+R  K + ST  GR L++ LP++ T+P++TA WE  L++++    S ++FM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  595  DLNQQLPHLLQSPNRQVL  612
              +Q +++L+     Q L
Sbjct  590  KQSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  389 bits (1464),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 254/618 (42%), Positives = 409/618 (67%), Gaps = 17/618 (2%)

Query  1    MRLFVAEKPSLARAIADVLPKPHTKGDGFIQCGEHDTVTWCIGHLLEQAEPDVYDERF-K  59
            MRL + EKPS +R IA  L   + +G+GF++ G   TVTW  GHLLE AEP+VY+E++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   MWRMEHLPIVPEQWKLIPKKETLKQFKVVEKLIKKADVLVNAGDPDREGQLLVDEVFGYL  119
             WR + LP++P+QWKL+ K ++  QF V+++L+K+ D +V A D+DREG+++  E+++Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAERKSQIQRCLVSDLNPNAVSRAIEKLQKNSDFIPLATSALARARADWLYGINMTRA  179
            ++    ++++ R  +S L+  ++  A+  L  +S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDYFEVLAQIVVPETQERFKA  239
            +TL GR AG   VLSVGRVQTP L+++V+RD EI++FV+K YFEV+A + V      F +
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL--FPS  232

Query  240  QWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQP-ATVTEYQNKIEKETAPLPYSLSVL  298
            +W P+    +Y DE+ R +   +A +VV+   + P A++ + Q    K++APL++SLS L
Sbjct  233  KWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  299  QMEAAGRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPTEHFNDRFKVMAAIAHHLPE  358
            Q   + + G++AQ+VLDI QKLYETHKL TYPR+D  YLP    ++  +V++A+    P 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  359  YQQKPEVIDATIRNRCWNDKEVEAHHAIIPTARQGTV-HLTENEKRVYQLIARQYLMQFC  417
             Q     +D+ + +R WNDK + AHH+IIPT + G +  L++ E+ VYQL+  +YL QF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PDAEYRKSKIGLEIAGGSFVAQARNLVIAGWRALLGK---EDSLDDAEPLLPIVKKGQIL  474
            P+ E   +   ++I+G  F +++  LV +GW++L+GK   +D  + +E  LP ++ GQ+ 
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  475  HCEKGEIVSKKTQPPRHFTDRSLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIE  534
            + + +E    +T+PP  + D +L++AMT  A FV D  LKK+L+E  G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  535  LLFKRGFLIRKGKNIHSTEAGRILIQALPDSATQPDMTAHWEMQLNQISKKETSYQQFMF  594
             L+KRGFL+R  K + ST  GR L++ LP++ T+P++TA WE  L++++    S ++FM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  595  DLNQQLPHLLQSPNRQVL  612
              +Q +++L+     Q L
Sbjct  590  KQSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  389 bits (1464),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 254/618 (42%), Positives = 409/618 (67%), Gaps = 17/618 (2%)

Query  1    MRLFVAEKPSLARAIADVLPKPHTKGDGFIQCGEHDTVTWCIGHLLEQAEPDVYDERF-K  59
            MRL + EKPS +R IA  L   + +G+GF++ G   TVTW  GHLLE AEP+VY+E++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   MWRMEHLPIVPEQWKLIPKKETLKQFKVVEKLIKKADVLVNAGDPDREGQLLVDEVFGYL  119
             WR + LP++P+QWKL+ K ++  QF V+++L+K+ D +V A D+DREG+++  E+++Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAERKSQIQRCLVSDLNPNAVSRAIEKLQKNSDFIPLATSALARARADWLYGINMTRA  179
            ++    ++++ R  +S L+  ++  A+  L  +S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDYFEVLAQIVVPETQERFKA  239
            +TL GR AG   VLSVGRVQTP L+++V+RD EI++FV+K YFEV+A + V      F +
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL--FPS  232

Query  240  QWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQP-ATVTEYQNKIEKETAPLPYSLSVL  298
            +W P+    +Y DE+ R +   +A +VV+   + P A++ + Q    K++APL++SLS L
Sbjct  233  KWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  299  QMEAAGRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPTEHFNDRFKVMAAIAHHLPE  358
            Q   + + G++AQ+VLDI QKLYETHKL TYPR+D  YLP    ++  +V++A+    P 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  359  YQQKPEVIDATIRNRCWNDKEVEAHHAIIPTARQGTV-HLTENEKRVYQLIARQYLMQFC  417
             Q     +D+ + +R WNDK + AHH+IIPT + G +  L++ E+ VYQL+  +YL QF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PDAEYRKSKIGLEIAGGSFVAQARNLVIAGWRALLGK---EDSLDDAEPLLPIVKKGQIL  474
            P+ E   +   ++I+G  F +++  LV +GW++L+GK   +D  + +E  LP ++ GQ+ 
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  475  HCEKGEIVSKKTQPPRHFTDRSLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIE  534
            + + +E    +T+PP  + D +L++AMT  A FV D  LKK+L+E  G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  535  LLFKRGFLIRKGKNIHSTEAGRILIQALPDSATQPDMTAHWEMQLNQISKKETSYQQFMF  594
             L+KRGFL+R  K + ST  GR L++ LP++ T+P++TA WE  L++++    S ++FM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  595  DLNQQLPHLLQSPNRQVL  612
              +Q +++L+     Q L
Sbjct  590  KQSQWVSQLVAQGRSQPL  607

> AF000001|2|G1|6513858|AAF14809.1|Salmonella_enterica_subsp._enterica_serovar_Typhi_str._Ty2|+|1905..3899|topB|-|topoisomerase 
B
Length=664

 Score =  389 bits (1464),  Expect = 2e-109, Method: Compositional matrix adjust.
 Identities = 254/618 (42%), Positives = 409/618 (67%), Gaps = 17/618 (2%)

Query  1    MRLFVAEKPSLARAIADVLPKPHTKGDGFIQCGEHDTVTWCIGHLLEQAEPDVYDERF-K  59
            MRL + EKPS +R IA  L   + +G+GF++ G   TVTW  GHLLE AEP+VY+E++ K
Sbjct  1    MRLVLCEKPSQGRDIAKFLGATQ-RGEGFLN-GPGVTVTWARGHLLETAEPEVYGEQYGK  58

Query  60   MWRMEHLPIVPEQWKLIPKKETLKQFKVVEKLIKKADVLVNAGDPDREGQLLVDEVFGYL  119
             WR + LP++P+QWKL+ K ++  QF V+++L+K+ D +V A D+DREG+++  E+++Y 
Sbjct  59   PWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYC  118

Query  120  NLSAERKSQIQRCLVSDLNPNAVSRAIEKLQKNSDFIPLATSALARARADWLYGINMTRA  179
            ++    ++++ R  +S L+  ++  A+  L  +S   +L  ++++R+RADWL G+N+TR 
Sbjct  119  KF----QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRL  174

Query  180  YTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDYFEVLAQIVVPETQERFKA  239
            +TL GR AG   VLSVGRVQTP L+++V+RD EI++FV+K YFEV+A + V      F +
Sbjct  175  FTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVL--FPS  232

Query  240  QWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQP-ATVTEYQNKIEKETAPLPYSLSVL  298
            +W P+    +Y DE+ R +   +A +VV+   + P A++ + Q    K++APL++SLS L
Sbjct  233  KWVPA---AQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTL  289

Query  299  QMEAAGRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPTEHFNDRFKVMAAIAHHLPE  358
            Q   + + G++AQ+VLDI QKLYETHKL TYPR+D  YLP    ++  +V++A+    P 
Sbjct  290  QQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPA  349

Query  359  YQQKPEVIDATIRNRCWNDKEVEAHHAIIPTARQGTV-HLTENEKRVYQLIARQYLMQFC  417
             Q     +D+ + +R WNDK + AHH+IIPT + G +  L++ E+ VYQL+  +YL QF 
Sbjct  350  LQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFL  409

Query  418  PDAEYRKSKIGLEIAGGSFVAQARNLVIAGWRALLGK---EDSLDDAEPLLPIVKKGQIL  474
            P+ E   +   ++I+G  F +++  LV +GW++L+GK   +D  + +E  LP ++ GQ+ 
Sbjct  410  PQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVC  469

Query  475  HCEKGEIVSKKTQPPRHFTDRSLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIE  534
            + + +E    +T+PP  + D +L++AMT  A FV D  LKK+L+E  G+GTEATRAGII+
Sbjct  470  QVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIID  529

Query  535  LLFKRGFLIRKGKNIHSTEAGRILIQALPDSATQPDMTAHWEMQLNQISKKETSYQQFMF  594
             L+KRGFL+R  K + ST  GR L++ LP++ T+P++TA WE  L++++    S ++FM 
Sbjct  530  TLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMA  589

Query  595  DLNQQLPHLLQSPNRQVL  612
              +Q +++L+     Q L
Sbjct  590  KQSQWVSQLVAQGRSQPL  607