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Homologs of dfrA5 gene of JN559393

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) dhfrV
( YP_001740004.1 )

dihydrofolate reductase type 5

NC_010488
(Escherichia coli SMS-3-5)

6e-63

2) dhfR
( NP_569370.1 )

dihydrofolate reductase

NC_003384
(Salmonella enterica CT18)

6e-63

3) ST548_p1188
( YP_007386304.1 )

Dihydrofolate reductase

NC_020180
(Enterobacter aerogenes EA1509E)

1e-53

4) NRG857_30100
( YP_006162239.1 )

dihydrofolate reductase type I DhfrA1

NC_017659
(Escherichia coli NRG 857C)

1e-53

5) A225_R1p0435
( YP_006501701.1 )

Dhfr1

NC_018107
(Klebsiella oxytoca E718)

1e-53

6) dhfrI
( YP_001715373.1 )

dihydrofolate reductase type 1 (dihydrofolate reductase type I) (trimethoprim resistance protein)

NC_010410
(Acinetobacter baumannii AYE)

2e-53

7) SFxv_4142a
( YP_005729392.1 )

trimethoprim resistance protein,type I dihydrofolate reductase

NC_017328
(Shigella flexneri 2002017)

2e-53

8) DP0311
( YP_064047.1 )

dihydrofolate reductase, type VII

NC_006138
(Desulfotalea psychrophila LSv54)

2e-47

9) O3M_00535
( YP_006767792.1 )

dihydrofolate reductase

NC_018650
(Escherichia coli 2009EL-2050)

1e-46

10) O3O_25165
( YP_006781897.1 )

dihydrofolate reductase

NC_018661
(Escherichia coli 2009EL-2071)

1e-46

11) O3K_00505
( YP_006776837.1 )

dihydrofolate reductase

NC_018658
(Escherichia coli 2011C-3493)

1e-46

12) Kfla_5968
( YP_003383770.1 )

dihydrofolate reductase

NC_013729
(Kribbella flavida DSM 17836)

4e-18

13) Noca_2312
( YP_923504.1 )

dihydrofolate reductase

NC_008699
(Nocardioides sp. JS614)

9e-18

14) Intca_2184
( YP_004099420.1 )

dihydrofolate reductase

NC_014830
(Intrasporangium calvum DSM 43043)

5e-17

15) folA
( YP_004574294.1 )

dihydrofolate reductase

NC_015635
(Microlunatus phosphovorus NM-1)

7e-16

16) UMN179_01397
( YP_004420313.1 )

dihydrofolate reductase

NC_015460
(Gallibacterium anatis UMN179)

2e-15

17) Ccel_1310
( YP_002505644.1 )

dihydrofolate reductase subunit

NC_011898
(Clostridium cellulolyticum H10)

1e-14

18) KPHS_p300720
( YP_005221020.1 )

dihydrofolate reductase

NC_016839
(Klebsiella pneumoniae HS11286)

2e-14

19) Tbd_2039
( YP_315797.1 )

dihydrofolate reductase

NC_007404
(Thiobacillus denitrificans ATCC 25259)

3e-14

20) Mpop_2781
( YP_001925471.1 )

dihydrofolate reductase

NC_010725
(Methylobacterium populi BJ001)

7e-14

21) folA
( YP_004833673.1 )

dihydrofolate reductase

NC_015976
(Sphingobium sp. SYK-6)

1e-13

22) folA
( YP_002773868.1 )

dihydrofolate reductase

NC_012491
(Brevibacillus brevis NBRC 100599)

3e-13

23) RPD_3353
( YP_570478.1 )

dihydrofolate reductase

NC_007958
(Rhodopseudomonas palustris BisB5)

3e-13

24) Runsl_2666
( YP_004656198.1 )

dihydrofolate reductase

NC_015703
(Runella slithyformis DSM 19594)

2e-12

25) Mesop_3614
( YP_004612150.1 )

dihydrofolate reductase

NC_015675
(Mesorhizobium opportunistum WSM2075)

8e-12

26) Mlg_0423
( YP_741267.1 )

dihydrofolate reductase

NC_008340
(Alkalilimnicola ehrlichii MLHE-1)

4e-10

27) Theco_1713
( YP_007212843.1 )

dihydrofolate reductase

NC_019897
(Thermobacillus composti KWC4)

3e-09

• Sequence Alignments

1) dhfrV in NC_010488


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  233 bits (867),  Expect = 6e-63, Method: Compositional matrix adjust.
 Identities = 137/152 (91%), Positives = 149/152 (99%), Gaps = 0/152 (0%)

Query  9    MAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  68
            MAAKAKNGVIGCGP+IPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  69   GWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDIEPEGD  128
            +WT+++DNV+VF SIEEAM  LAE+T+HVIVSGGGEIYRETLPMASTLH+STIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  129  VFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            VFFP+IPNTFEVVFEQHF+SNINYCYQIW+KG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

2) dhfR in NC_003384


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  233 bits (867),  Expect = 6e-63, Method: Compositional matrix adjust.
 Identities = 137/152 (91%), Positives = 149/152 (99%), Gaps = 0/152 (0%)

Query  9    MAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  68
            MAAKAKNGVIGCGP+IPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  69   GWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDIEPEGD  128
            +WT+++DNV+VF SIEEAM  LAE+T+HVIVSGGGEIYRETLPMASTLH+STIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  129  VFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            VFFP+IPNTFEVVFEQHF+SNINYCYQIW+KG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

3) ST548_p1188 in NC_020180


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  202 bits (749),  Expect = 1e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

4) NRG857_30100 in NC_017659


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  202 bits (749),  Expect = 1e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

5) A225_R1p0435 in NC_018107


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  202 bits (749),  Expect = 1e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

6) dhfrI in NC_010410


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  201 bits (746),  Expect = 2e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

7) SFxv_4142a in NC_017328


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  201 bits (746),  Expect = 2e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

8) VCD_003671 in NC_012668


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  201 bits (746),  Expect = 2e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

9) dfrA1 in NC_016445


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  201 bits (746),  Expect = 2e-53, Method: Compositional matrix adjust.
 Identities = 114/152 (75%), Positives = 132/152 (87%), Gaps = 0/152 (0%)

Query  6    MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS  65
            M A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYAVVTRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   SFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD  125
            + T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDIEPEGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  VYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            V+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

10) DP0311 in NC_006138


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  181 bits (671),  Expect = 2e-47, Method: Compositional matrix adjust.
 Identities = 97/151 (65%), Positives = 128/151 (85%), Gaps = 0/151 (0%)

Query  6    MAAKSENGVIGKGADIPWMVKGEQLLFKAITFNQWLLVGRKTFDSMGVLPNRKYAVITRS  65
            MAAK+ NGVIG G++IPW  KGEQLLFKA+T+NQWLLVGRKTF+SMG LPNRKYAV+TRS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   GLLSQNDNVLVFPSIEDALRELAQQTEHIIVAGGGEIFKAMINRADTLHLSTVHQNIDGD  125
            +  ++NDNV+VFPSIE+A+  LA+ T+H+IV+GGGEI++  +  A TLH+ST++ + +GD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  ITFPQVPKDFKLVFEQYFESNINYTYQIWQR  156
            + FP++P+ F +VFEQ F SNINY YQIWQ+
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQK  151

11) O3M_00535 in NC_018650


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  178 bits (660),  Expect = 1e-46, Method: Compositional matrix adjust.
 Identities = 99/152 (66%), Positives = 127/152 (84%), Gaps = 0/152 (0%)

Query  6    ISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSRK  65
            ++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYAVV+R 
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   GISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVEVEGD  125
            + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++E EGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  INFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            + FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

12) O3O_25165 in NC_018661


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  178 bits (660),  Expect = 1e-46, Method: Compositional matrix adjust.
 Identities = 99/152 (66%), Positives = 127/152 (84%), Gaps = 0/152 (0%)

Query  6    ISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSRK  65
            ++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYAVV+R 
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   GISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVEVEGD  125
            + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++E EGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  INFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            + FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

13) O3K_00505 in NC_018658


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  178 bits (660),  Expect = 1e-46, Method: Compositional matrix adjust.
 Identities = 99/152 (66%), Positives = 127/152 (84%), Gaps = 0/152 (0%)

Query  6    ISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSRK  65
            ++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYAVV+R 
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  66   GISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVEVEGD  125
            + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++E EGD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  126  INFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            + FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

14) VS_1884 in NC_011753


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score =  156 bits (576),  Expect = 7e-40, Method: Compositional matrix adjust.
 Identities = 90/152 (60%), Positives = 122/152 (81%), Gaps = 0/152 (0%)

Query  32   MAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKLPNRKYAVISRS  91
            MAA A NGVIG G +IPW  KGEQLLFKA+T+NQWLL+GRKTFESMG LPNRKYAV++RS
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRS  60

Query  92   PSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTihiskihkhisGD  151
            + T+++ +++ F S+E+A+  L  +T+H +VSGGG+IY+  +    T+HIS I+ +  GD
Sbjct  61   AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  152  IFFPELPRDLTLVFEQRFSSNIDYTYQIWQKG  183
            +FFP++P  + +VFEQ+FSSNI+Y YQIWQKG
Sbjct  121  VFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  152

15) Kfla_5968 in NC_013729


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 84.2 bits (300),  Expect = 4e-18, Method: Compositional matrix adjust.
 Identities = 56/131 (43%), Positives = 87/131 (67%), Gaps = 6/131 (4%)

Query  6    IAAVGRNGVIGRDNELPWRIREDLQHFKALTLGHTLVMGRKTYDSIGRPLPGRRTVVVTR  65
            +AA ++NGVIG + ++PW  + +   FKALT  + L++GRKT++S+G +LP R+  VVTR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  66   QPDWSA--PGVEVAHSLAAAL-ELAD-GKDVYVAGGGEIYRQALPSADRLELTEVDQSPA  121
             + W+A    V V  S+  A+  LA+   +V V+GGGEIYR++LP A  L+++ +D  P 
Sbjct  60   -SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPE  118

Query  122  GDVTFPAVDRS  132
            GDV FP +  +
Sbjct  119  GDVFFPNIPNT  129

16) Noca_2312 in NC_008699


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 83.1 bits (296),  Expect = 9e-18, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 88/127 (70%), Gaps = 4/127 (3%)

Query  11   VAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIVLTR  70
            +AA A+NGVIG GP+IPW   GEQ LFK+LT  + L++GR T++S+G +LP R   V+TR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  71   SPDWSAEGvhvahdlpaalal--adTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEPQ  128
            S+ W+A+  +V    +   A+     L ++V+V+GGG++Y  +LP+A    +S +D+EP+
Sbjct  60   SA-WTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPE  118

Query  129  GDAFYPE  135
            GD F+P+
Sbjct  119  GDVFFPN  125

17) Intca_2184 in NC_014830


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 80.7 bits (287),  Expect = 5e-17, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 85/127 (67%), Gaps = 4/127 (3%)

Query  7    IAAVGRNGVIGDGSTMLWHIPEDLKFFKRTTMGHPMIMGRRTFETMGVLPGRRSIVVTRQ  66
            +AA ++NGVIG G+ + W    +  +FK  T  + +++GR+TFE+MG LP R+  VVTR 
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTR-  59

Query  67   PDWA--HPGVETAHSLAEAL-SLAGPADEVFIVGGGEVYREAMPYAARLVITEVDQAPDG  123
            + W+  +  V    S+ EA+ +LA  +D+V++ GGGE+YRE++P A+ L I+ +D  P+G
Sbjct  60   SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEG  119

Query  124  SVTFPEI  130
             V FP+I
Sbjct  120  DVFFPNI  126

18) folA in NC_015635


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 76.8 bits (272),  Expect = 7e-16, Method: Compositional matrix adjust.
 Identities = 59/142 (42%), Positives = 89/142 (63%), Gaps = 9/142 (6%)

Query  4    IAAVARNGVIGAGNDIPWRIKEDWARFKAITMGHVLIMGRKTYDSIGRPLPGRTTIVVTR  63
            +AA A+NGVIG G +IPW  K +   FKA+T  + L++GRKT++S+G +LP R   VVTR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  64   DPDWTA--DGIRTAHNLDDAFEVAYALA--PEKVFVAGGGQIYAAAWDRLDVLEITEVDI  119
             + WTA  D +    ++++A    Y+LA   + V+V+GGG+IY  +      L+I+ +DI
Sbjct  60   SA-WTADNDNVIVFPSIEEA---MYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  115

Query  120  EPAGEVRFPLIGPEWVVVSREQ  141
            EP G+V FP I     VV  ++
Sbjct  116  EPEGDVFFPNIPNTFEVVFEQH  137

19) UMN179_01397 in NC_015460


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 75.0 bits (265),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 51/127 (41%), Positives = 85/127 (67%), Gaps = 4/127 (3%)

Query  5    IVAMSKNRVIGRDNQMPWHLPADLAWFKKNTLGKPVIMGRKTFQSIGRALPNRKNIVLSR  64
            + A +KN VIG + ++PW   ++   FK  T  + +++GRKTF+S+G ALPNRK  V++R
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  65   QGFQADGIEVV--SDLSQAL-ALIKGENEVMVIGGGHLFAETLPIADRLYLTEIDAELQG  121
             +  AD  +V+  + + +A+ +L    ++V+V GGG+++ ETLP+A  L ++ ID E +G
Sbjct  60   SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEG  119

Query  122  DTFFPEI  128
            D FFP+I
Sbjct  120  DVFFPNI  126

20) Ccel_1310 in NC_011898


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 72.9 bits (257),  Expect = 1e-14, Method: Compositional matrix adjust.
 Identities = 53/125 (43%), Positives = 81/125 (65%), Gaps = 4/125 (3%)

Query  7    AMGRNNALGCKNRMPWYIPADFAYFKKVTMGKPVIMGRKTFESIGKPLPGRKNIVITRDT  66
            A ++N  +GC  ++PW   ++   FK +T  + +++GRKTFES+G +LP RK  V+TR +
Sbjct  3    AKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRSA  61

Query  67   -GYDPQGCIVVNSIEKAM-EYTE-EKEVFIIGGAEIYKEFLPIADRLYITLIEKEFEADA  123
               D +  IV  SIE AM   +E   +V++ GG+EIY+E LP+A  L I+ I+ E E+D 
Sbjct  62   WTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGDV  121

Query  124  FFPEI  128
            FFP+I
Sbjct  122  FFPNI  126

21) KPHS_p300720 in NC_016839


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 72.1 bits (254),  Expect = 2e-14, Method: Compositional matrix adjust.
 Identities = 53/129 (42%), Positives = 86/129 (67%), Gaps = 2/129 (1%)

Query  11   VAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR  70
            +AA + N VIG GP+IPW   GEQ +F+ LT  + +++GRKTFES+G +LPNR   V++R
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  71   QANYRATGCVVV-STLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129
             A     + V+V +++ +A+   +EL +++ V+GG+EIY  +LP A  + +S ++   EG
Sbjct  60   SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEG  119

Query  130  DAFFPMLNE  138
            D FFP + +
Sbjct  120  DVFFPNIPN  128

22) Tbd_2039 in NC_007404


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 71.5 bits (252),  Expect = 3e-14, Method: Compositional matrix adjust.
 Identities = 52/126 (42%), Positives = 84/126 (67%), Gaps = 3/126 (2%)

Query  12   IAALAKNRVIGIENRLPWRLPEDLAHFKALTLDHPVLMGRKTFESLGRPLPRRTNVVITR  71
            +AA AKN VIG   ++PW    +   FKALT ++ +L+GRKTFES+G +LP R   V+TR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  72   NA-DYRPDGCLVAASMPAAI-ALCQGADEIFFIGGAELYAQAIPLADRLYLTEVDAEPEG  129
            +A     D  +V +S+  A+ +L + +D+++  GG+E+Y +++P+A  L ++ +D EPEG
Sbjct  60   SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEG  119

Query  130  DAWFPE  135
            D  FP+
Sbjct  120  DVFFPN  125

23) Mpop_2781 in NC_010725


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 70.0 bits (246),  Expect = 7e-14, Method: Compositional matrix adjust.
 Identities = 51/125 (41%), Positives = 82/125 (66%), Gaps = 4/125 (3%)

Query  9    IAAVARNGVIGRDNDLVWRISSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSLVLTR  68
            +AA A+NGVIG + ++ W   ++   FKALT  + +L+GRKT +S+G +LP R+  V+TR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  69   D-RALTLSDVTIVHDWDEALAAAG--GDELMVVGGAEIYRLALPHADRLHLTEVDAAPEG  125
              ++    +V +    +EA+ + +   D+++V GG+EIYR +LP A  LH++ +D  PEG
Sbjct  60   SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEG  119

Query  126  DVHFP  130
            DV FP
Sbjct  120  DVFFP  124

24) folA in NC_015976


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 69.2 bits (243),  Expect = 1e-13, Method: Compositional matrix adjust.
 Identities = 52/122 (43%), Positives = 80/122 (66%), Gaps = 6/122 (4%)

Query  11   LLARADNGVIGSEGDIPWHIPGEQRRFKAMTMGTPMVMGRKTFDSLPRLLPGRRHIVLTR  70
            + A+A NGVIG   +IPW   GEQ  FKA+T    +++GRKTF+S+   LP R+  V+TR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGA-LPNRKYAVVTR  59

Query  71   DRAWQAEGAEVV--HSVEEAI-AIAR-APVLSVIGGAEIYRLFEPVADRLEITQVGLNPP  126
              AW A+  +V+   S+EEA+ ++A  +  + V GG+EIYR   P+A  L+I+ ++++P 
Sbjct  60   S-AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPE  118

Query  127  GD  128
            GD
Sbjct  119  GD  120

25) folA in NC_012491


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 67.9 bits (238),  Expect = 3e-13, Method: Compositional matrix adjust.
 Identities = 50/122 (41%), Positives = 78/122 (64%), Gaps = 7/122 (5%)

Query  9    ARNQVIGKDGDMPWHLPADLKNVKELTTGKTIVMGRKTFESIGKPLPNRRNVVLTRSQ-D  67
            A+N VIG + ++PW   ++    K LT  + +++GRKTFES+G +LPNR+  V+TRS   
Sbjct  5    AKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRSAWT  63

Query  68   FHPEGVDVVHTKEEVL-AMGD----VIIFGGSEIYRQFLDVVDRLYITEIDLETEGDTFF  122
             + + V V  + EE + ++++    VI+ GG+EIYR+ L +   L I+ ID+E EGD FF
Sbjct  64   ADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGDVFF  123

Query  123  PA  124
            P 
Sbjct  124  PN  125

26) RPD_3353 in NC_007958


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 67.9 bits (238),  Expect = 3e-13, Method: Compositional matrix adjust.
 Identities = 51/126 (41%), Positives = 80/126 (64%), Gaps = 7/126 (5%)

Query  21   NGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIVVTRDT-HFQ  79
            NGVIG G  IPW  K++Q  FK LT N+ +++GRKT++S+G +LP R   VVTR +   +
Sbjct  7    NGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRSAWTAD  65

Query  80   AAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTEVHASPQGD  139
               V+V PS+E A       ++   + +V+V GG+EIY + LP A+ ++++ ++  P+GD
Sbjct  66   NDNVIVFPSIEEAMY-----GLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  120

Query  140  TTFPAI  145
              FP I
Sbjct  121  VFFPNI  126

27) Runsl_2666 in NC_015703


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 65.2 bits (228),  Expect = 2e-12, Method: Compositional matrix adjust.
 Identities = 53/131 (41%), Positives = 82/131 (63%), Gaps = 6/131 (4%)

Query  6    IVAAAQNGVIGRDNQLIWHLPDDLKQFKRLTTGHPILMGRKTFESIGKPLPNRTSIVITR  65
            + A A+NGVIG + ++ W   ++   FK LT  + +L+GRKTFES+G +LPNR   V+TR
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  59

Query  66   NQHW--QFEGVMVVNSVEEAIEAARQTGTDEAFVIGGAEIYRMMLPAVDKIYLTEVKAIF  123
            +  W  + + V+V  S+EEA+ +  +  TD+ +V GG+EIYR  LP    + ++ +    
Sbjct  60   SA-WTADNDNVIVFPSIEEAMYGLAEL-TDHVIVSGGGEIYRETLPMASTLHISTIDIEP  117

Query  124  EGDAFF-RIPD  133
            EGD FF  IP+
Sbjct  118  EGDVFFPNIPN  128

28) Mesop_3614 in NC_015675


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 63.1 bits (220),  Expect = 8e-12, Method: Compositional matrix adjust.
 Identities = 53/131 (41%), Positives = 78/131 (60%), Gaps = 12/131 (9%)

Query  10   AENGVIGRDGGLPWRLSTDLKRFKADTMGKPIIMGRKTYEGIGRPLPGRLNIVVTRDKAW  69
            A NGVIG +  +PW    +   FKA T  + +++GRKT+E++G +LP R   VVTR  AW
Sbjct  5    AKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRS-AW  62

Query  70   RAEG--VEVAHTLEAAI-QLANVRGRCMTGVDEVCVIGGGEIYAQALPLADRLHVTHVLA  126
             A+   V V  ++E A+  LA++        D+V V GGGEIY ++LP+A  LH++ +  
Sbjct  63   TADNDNVIVFPSIEEAMYGLAEL-------TDHVIVSGGGEIYRETLPMASTLHISTIDI  115

Query  127  AVDGDAHFPPI  137
              +GD  FP I
Sbjct  116  EPEGDVFFPNI  126

29) Mlg_0423 in NC_008340


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 57.6 bits (199),  Expect = 4e-10, Method: Compositional matrix adjust.
 Identities = 58/144 (41%), Positives = 88/144 (62%), Gaps = 6/144 (4%)

Query  10   IAALADNGVIGRDNDLPWRIPADLKRFKARTQGRPLIMGRRNYESIGRPLPGRHNIVLTR  69
            +AA A NGVIG + ++PW   ++   FKA T  + L++GR+ +ES+G +LP R   V+T 
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVT-  58

Query  70   RRDWQAEGCTVVHDP---EAALAAAGDveevmviggeeiYRLFLPRADRLELTRVHTEVP  126
            R  W A+   V+  P   EA  + A   ++V+V GG EIYR  LP A  L+++ ++ E  
Sbjct  59   RSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPE  118

Query  127  GDTFFPDIDPADWQVVAEQQPPSE  150
            GD FFP+I P   +VV EQ+ +S+
Sbjct  119  GDVFFPNI-PNTFEVVFEQHFSSN  141

30) Theco_1713 in NC_019897


> JN559393|15|G8|382929433|AFG30110.1|Pseudomonas_aeruginosa_U6|+|9585..10043|dfrA5|-|dihydrofolate 
reductase
Length=152

 Score = 54.7 bits (188),  Expect = 3e-09, Method: Compositional matrix adjust.
 Identities = 52/129 (41%), Positives = 78/129 (61%), Gaps = 9/129 (6%)

Query  6    IAAMARNRVIGQDNGLPWRLPDDLKFFMRSTLGRTVLMGRRTFESLPGGPLKNRLNVVLT  65
            +AA A+N VIG +  +PW   ++  +F   T  + +L+GR+TFES+  G+L NR   V+T
Sbjct  1    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESM--GALPNRKYAVVT  58

Query  66   RQA-DYRPDGCEVVHSVEEALSRYGDGEL----MVAGGAEVYRWFLPHADRMLLTEVDAE  120
            R A     D   V  S+EEA+  YG +EL    +V+GG+E+YR  LP A  + ++ +D E
Sbjct  59   RSAWTADNDNVIVFPSIEEAM--YGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE  116

Query  121  VEGDARFPE  129
             EGD  FP+
Sbjct  117  PEGDVFFPN  125