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Homologs of dfrA12 gene of EU780013

261

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) A225_R1p0770
( YP_006501616.1 )

Dihydrofolate reductase

NC_018107
(Klebsiella oxytoca E718)

3e-75

100

2) N559_5185
( YP_008414966.1 )

dihydrofolate reductase

NC_022078
(Klebsiella pneumoniae JM45)

3e-75

100

3) tri
( YP_209335.1 )

dihydrofolate reductase

NC_006856
(Salmonella enterica SC-B67)

3e-75

100

4) STMDT12_L00660
( YP_005250485.1 )

dihydrofolate reductase

NC_016861
(Salmonella enterica T000240)

3e-75

100

5) STU288_1p00755
( YP_007905885.1 )

dihydrofolate reductase

NC_021155
(Salmonella enterica U288)

3e-75

100

6) KPHS_p300720
( YP_005221020.1 )

dihydrofolate reductase

NC_016839
(Klebsiella pneumoniae HS11286)

9e-63

7) Hneap_1653
( YP_003263526.1 )

dihydrofolate reductase

NC_013422
(Halothiobacillus neapolitanus c2)

3e-60

8) MCCL_plsB0051
( YP_002559382.1 )

hypothetical protein

NC_011996
(Macrococcus caseolyticus JCSC5402)

2e-36

9) Gura_0932
( YP_001229711.1 )

dihydrofolate reductase

NC_009483
(Geobacter uraniireducens Rf4)

5e-35

10) Geob_1750
( YP_002537209.1 )

dihydrofolate reductase

NC_011979
(Geobacter daltonii FRC-32)

2e-33

11) Clocel_0240
( YP_003841788.1 )

dihydrofolate reductase subunit

NC_014393
(Clostridium cellulovorans 743B)

1e-31

12) Fjoh_1468
( YP_001193819.1 )

dihydrofolate reductase

NC_009441
(Flavobacterium johnsoniae UW101)

9e-32

13) SSUBM407_0957
( YP_003028702.1 )

dihydrofolate reductase

NC_012926
(Streptococcus suis BM407)

2e-31

14) Mar181_0627
( YP_004480603.1 )

dihydrofolate reductase

NC_015559
(Marinomonas posidonica IVIA-Po-181)

8e-31

15) Mmwyl1_3741
( YP_001342577.1 )

dihydrofolate reductase

NC_009654
(Marinomonas sp. MWYL1)

4e-30

16) dfrA
( NP_244317.1 )

dihydrofolate reductase

NC_002570
(Bacillus halodurans C-125)

4e-30

17) dfrD_2
( YP_008395020.1 )

dihydrofolate reductase, DfrD_2

NC_021994
(Enterococcus faecium AUS0085)

8e-30

18) Marme_0712
( YP_004311831.1 )

dihydrofolate reductase

NC_015276
(Marinomonas mediterranea MMB-1)

1e-29

19) Slin_1051
( YP_003385901.1 )

Dihydrofolate reductase

NC_013730
(Spirosoma linguale DSM 74)

4e-29

20) Weevi_0641
( YP_004237936.1 )

dihydrofolate reductase

NC_015144
(Weeksella virosa DSM 16922)

4e-29

21) STH3116
( YP_076942.1 )

dihydrofolate reductase

NC_006177
(Symbiobacterium thermophilum IAM 14863)

5e-29

22) Oweho_2962
( YP_004990564.1 )

dihydrofolate reductase

NC_016599
(Owenweeksia hongkongensis DSM 17368)

1e-28

23) Tbd_2039
( YP_315797.1 )

dihydrofolate reductase

NC_007404
(Thiobacillus denitrificans ATCC 25259)

1e-28

24) Pjdr2_2656
( YP_003011396.1 )

dihydrofolate reductase

NC_012914
(Paenibacillus sp. JDR-2)

2e-28

25) EUBELI_01781
( YP_002931218.1 )

dihydrofolate reductase

NC_012778
(Eubacterium eligens ATCC 27750)

2e-28

26) B565_0876
( YP_004391528.1 )

dihydrofolate reductase type 3

NC_015424
(Aeromonas veronii B565)

2e-28

27) Lcho_1259
( YP_001790293.1 )

dihydrofolate reductase

NC_010524
(Leptothrix cholodnii SP-6)

2e-28

28) folA
( YP_006819097.1 )

protein containing dihydrofolate reductase region domain

NC_018691
(Alcanivorax dieselolei B5)

2e-28

29) folA
( YP_694063.1 )

dihydrofolate reductase

NC_008260
(Alcanivorax borkumensis SK2)

3e-28

30) folA
( YP_006721905.1 )

dihydrofolate reductase

NC_007517
(Geobacter metallireducens GS-15)

4e-28

31) folA
( YP_001140814.1 )

dihydrofolate reductase

NC_009348
(Aeromonas salmonicida A449)

1e-27

32) Phep_1421
( YP_003091697.1 )

dihydrofolate reductase

NC_013061
(Pedobacter heparinus DSM 2366)

2e-27

33) TKWG_20480
( YP_006380827.1 )

hypothetical protein

NC_017964
(Advenella kashmirensis WT001)

2e-27

34) Krodi_0787
( YP_004430039.1 )

dihydrofolate reductase subunit

NC_015496
(Krokinobacter sp. 4H-3-7-5)

2e-27

35) Metme_4551
( YP_004515389.1 )

Dihydrofolate reductase

NC_015572
(Methylomonas methanica MC09)

3e-27

36) folA
( YP_785039.1 )

dihydrofolate reductase

NC_010645
(Bordetella avium 197N)

4e-27

37) dfrA
( YP_005493359.1 )

dihydrofolate reductase subunit

NC_017138
(Bacillus megaterium WSH-002)

4e-27

38) Swoo_1009
( YP_001759397.1 )

dihydrofolate reductase

NC_010506
(Shewanella woodyi ATCC 51908)

4e-27

39) Theco_1713
( YP_007212843.1 )

dihydrofolate reductase

NC_019897
(Thermobacillus composti KWC4)

5e-27

40) Runsl_2666
( YP_004656198.1 )

dihydrofolate reductase

NC_015703
(Runella slithyformis DSM 19594)

6e-27

41) M5M_13555
( YP_006917581.1 )

dihydrofolate reductase

NC_018868
(Simiduia agarivorans SA1)

6e-27

42) folA
( YP_003981636.1 )

dihydrofolate reductase

NC_014640
(Achromobacter xylosoxidans A8)

6e-27

43) Ccel_1310
( YP_002505644.1 )

dihydrofolate reductase subunit

NC_011898
(Clostridium cellulolyticum H10)

6e-27

44) TOL_3595
( YP_007684216.1 )

dihydrofolate reductase

NC_020888
(Thalassolituus oleivorans MIL-1)

1e-26

45) folA
( YP_857866.1 )

dihydrofolate reductase

NC_008570
(Aeromonas hydrophila ATCC 7966)

2e-26

46) folA
( YP_005082760.1 )

Dihydrofolate reductase type III DHFR

NC_016642
(Pseudovibrio sp. FO-BEG1)

3e-26

47) AHML_18030
( YP_008044719.1 )

dihydrofolate reductase

NC_021290
(Aeromonas hydrophila ML09-119)

3e-26

48) Tgr7_2748
( YP_002514809.1 )

dihydrofolate reductase

NC_011901
(Thioalkalivibrio sulfidophilus HL-EbGR7)

4e-26

49) Noca_2312
( YP_923504.1 )

dihydrofolate reductase

NC_008699
(Nocardioides sp. JS614)

6e-26

50) Ssed_0959
( YP_001472698.1 )

dihydrofolate reductase

NC_009831
(Shewanella sediminis HAW-EB3)

1e-25

51) SCD_n01866
( YP_008546709.1 )

dihydrofolate reductase

NC_022357
(Sulfuricella denitrificans skB26)

1e-25

52) Tola_2373
( YP_002893556.1 )

Dihydrofolate reductase

NC_012691
(Tolumonas auensis DSM 9187)

7e-26

53) folA
( YP_001632651.1 )

hypothetical protein

NC_010170
(Bordetella petrii DSM 12804)

8e-26

54) Mnod_0700
( YP_002496035.1 )

dihydrofolate reductase subunit

NC_011894
(Methylobacterium nodulans ORS 2060)

2e-25

55) Shew185_1041
( YP_001365256.1 )

dihydrofolate reductase

NC_009665
(Shewanella baltica OS185)

2e-25

56) Sbal195_1074
( YP_001553510.1 )

dihydrofolate reductase

NC_009997
(Shewanella baltica OS195)

2e-25

57) Sbal678_1101
( YP_005272331.1 )

Dihydrofolate reductase

NC_016901
(Shewanella baltica OS678)

2e-25

58) NH44784_029401
( YP_008030023.1 )

Dihydrofolate reductase

NC_021285
(Achromobacter xylosoxidans NH44784-1996)

3e-25

59) folA
( YP_002304388.1 )

dihydrofolate reductase

NC_011527
(Coxiella burnetii CbuG_Q212)

3e-25

60) folA
( YP_002306287.1 )

dihydrofolate reductase

NC_011528
(Coxiella burnetii CbuK_Q154)

3e-25

61) folA
( YP_001425396.1 )

dihydrofolate reductase

NC_009727
(Coxiella burnetii Dugway 5J108-111)

3e-25

62) folA
( YP_001595986.1 )

dihydrofolate reductase

NC_010117
(Coxiella burnetii RSA 331)

3e-25

63) folA
( NP_820968.1 )

dihydrofolate reductase

NC_002971
(Coxiella burnetii RSA 493)

3e-25

64) folA
( YP_005428721.1 )

dihydrofolate reductase

NC_017067
(Marinobacter hydrocarbonoclasticus ATCC 49840)

3e-25

65) Kfla_5968
( YP_003383770.1 )

dihydrofolate reductase

NC_013729
(Kribbella flavida DSM 17836)

3e-25

66) Shal_0910
( YP_001673144.1 )

dihydrofolate reductase

NC_010334
(Shewanella halifaxensis HAW-EB4)

4e-25

67) Shew_0874
( YP_001093005.1 )

dihydrofolate reductase

NC_009092
(Shewanella loihica PV-4)

4e-25

68) UMN179_01397
( YP_004420313.1 )

dihydrofolate reductase

NC_015460
(Gallibacterium anatis UMN179)

5e-25

69) Maqu_2431
( YP_959693.1 )

dihydrofolate reductase

NC_008740
(Marinobacter aquaeolei VT8)

5e-25

70) Sama_2824
( YP_928696.1 )

dihydrofolate reductase

NC_008700
(Shewanella amazonensis SB2B)

8e-25

71) M446_1090
( YP_001768052.1 )

dihydrofolate reductase

NC_010511
(Methylobacterium sp. 4-46)

8e-25

72) Sden_2922
( YP_563923.1 )

dihydrofolate reductase

NC_007954
(Shewanella denitrificans OS217)

8e-25

73) Alvin_2149
( YP_003444102.1 )

dihydrofolate reductase

NC_013851
(Allochromatium vinosum DSM 180)

9e-25

74) Emtol_1434
( YP_006872607.1 )

dihydrofolate reductase region

NC_018748
(Emticicia oligotrophica DSM 17448)

1e-24

75) Lbys_2007
( YP_003998056.1 )

dihydrofolate reductase

NC_014655
(Leadbetterella byssophila DSM 17132)

1e-24

76) HP15_587
( YP_005884279.1 )

hypothetical protein

NC_017506
(Marinobacter adhaerens HP15)

1e-24

77) Hneap_0899
( YP_003262789.1 )

dihydrofolate reductase

NC_013422
(Halothiobacillus neapolitanus c2)

1e-24

78) dfrA
( YP_005356523.1 )

Dihydrofolate reductase

NC_017025
(Flavobacterium indicum GPTSA100-9)

2e-24

79) folA
( NP_719188.1 )

dihydrofolate reductase FolA

NC_004347
(Shewanella oneidensis MR-1)

2e-24

80) Mpop_2781
( YP_001925471.1 )

dihydrofolate reductase

NC_010725
(Methylobacterium populi BJ001)

3e-24

81) Aave_1448
( YP_969813.1 )

dihydrofolate reductase

NC_008752
(Acidovorax citrulli AAC00-1)

4e-24

82) FCOL_04070
( YP_004941441.1 )

dihydrofolate reductase

NC_016510
(Flavobacterium columnare ATCC 49512)

5e-24

83) Acav_1487
( YP_004233976.1 )

dihydrofolate reductase

NC_015138
(Acidovorax avenae ATCC 19860)

9e-24

84) dfrA
( YP_001295259.1 )

Dihydrofolate reductase

NC_009613
(Flavobacterium psychrophilum JIP02/86)

9e-24

85) Aeqsu_0718
( YP_006417241.1 )

dihydrofolate reductase

NC_018013
(Aequorivita sublithincola DSM 14238)

1e-23

86) Mlg_0423
( YP_741267.1 )

dihydrofolate reductase

NC_008340
(Alkalilimnicola ehrlichii MLHE-1)

1e-23

87) folA
( YP_001980992.1 )

dihydrofolate reductase

NC_010995
(Cellvibrio japonicus Ueda107)

1e-23

88) Clole_0608
( YP_004307540.1 )

dihydrofolate reductase

NC_015275
(Clostridium lentocellum DSM 5427)

1e-23

89) Spea_0857
( YP_001500719.1 )

dihydrofolate reductase

NC_009901
(Shewanella pealeana ATCC 700345)

2e-23

90) H045_19415
( YP_007399441.1 )

dihydrofolate reductase

NC_020209
(Pseudomonas poae RE*1-1-14)

2e-23

91) G432_09820
( YP_007616285.1 )

dihydrofolate reductase

NC_020561
(Sphingomonas sp. MM-1)

2e-23

92) PPE_02527
( YP_003870895.1 )

dihydrofolate reductase

NC_014483
(Paenibacillus polymyxa E681)

2e-23

93) PB2503_08189
( YP_003854835.1 )

dihydrofolate reductase FolA

NC_014414
(Parvularcula bermudensis HTCC2503)

2e-23

94) Psefu_4265
( YP_004476311.1 )

Dihydrofolate reductase

NC_015556
(Pseudomonas fulva 12-X)

4e-23

95) dfrA
( YP_002787091.1 )

dihydrofolate reductase

NC_012526
(Deinococcus deserti VCD115)

4e-23

96) folA
( NP_887420.1 )

dihydrofolate reductase

NC_002927
(Bordetella bronchiseptica RB50)

5e-23

97) LHK_00787
( YP_002794789.1 )

Dihydrofolate reductase

NC_012559
(Laribacter hongkongensis HLHK9)

5e-23

98) folA
( YP_003465092.1 )

hypothetical protein

NC_013891
(Listeria seeligeri SLCC3954)

5e-23

99) folA
( YP_005177290.1 )

dihydrofolate reductase

NC_016808
(Pasteurella multocida 36950)

6e-23

100) RPD_3353
( YP_570478.1 )

dihydrofolate reductase

NC_007958
(Rhodopseudomonas palustris BisB5)

6e-23

101) Coch_0487
( YP_003140611.1 )

Dihydrofolate reductase

NC_013162
(Capnocytophaga ochracea DSM 7271)

8e-23

102) dfrA
( YP_004735333.1 )

dihydrofolate reductase

NC_015844
(Zobellia galactanivorans DsiJT)

1e-22

103) NT08PM_1502
( YP_006240377.1 )

dihydrofolate reductase

NC_017764
(Pasteurella multocida 3480)

1e-22

104) folA
( YP_005363879.1 )

dihydrofolate reductase

NC_017027
(Pasteurella multocida HN06)

1e-22

105) folA
( NP_246832.1 )

hypothetical protein

NC_002663
(Pasteurella multocida Pm70)

1e-22

106) Sput200_0983
( YP_006008924.1 )

Dihydrofolate reductase

NC_017566
(Shewanella putrefaciens 200)

1e-22

107) folA
( YP_002897706.1 )

dihydrofolate reductase

NC_012695
(Burkholderia pseudomallei MSHR346)

1e-22

108) folA
( YP_006894835.1 )

dihydrofolate reductase

NC_018828
(Bordetella parapertussis Bpp5)

1e-22

109) Mrad2831_4526
( YP_001757175.1 )

dihydrofolate reductase

NC_010505
(Methylobacterium radiotolerans JCM 2831)

2e-22

110) Snov_3092
( YP_003694986.1 )

dihydrofolate reductase

NC_014217
(Starkeya novella DSM 506)

2e-22

111) folA
( YP_001345838.1 )

dihydrofolate reductase

NC_009656
(Pseudomonas aeruginosa PA7)

2e-22

112) P700755_003057
( YP_006868477.1 )

dihydrofolate reductase FolA

NC_018721
(Psychroflexus torquis ATCC 700755)

3e-22

113) CGSHiEE_07515
( YP_001291209.1 )

dihydrofolate reductase

NC_009566
(Haemophilus influenzae PittEE)

3e-22

114) K734_02390
( YP_008033979.1 )

dihydrofolate reductase

NC_021286
(Idiomarina loihiensis GSL 199)

3e-22

115) folA
( YP_154870.1 )

dihydrofolate reductase

NC_006512
(Idiomarina loihiensis L2TR)

3e-22

116) Nham_2729
( YP_577968.1 )

dihydrofolate reductase

NC_007964
(Nitrobacter hamburgensis X14)

3e-22

117) Ping_1045
( YP_942483.1 )

dihydrofolate reductase

NC_008709
(Psychromonas ingrahamii 37)

5e-22

118) Rpdx1_1866
( YP_004108211.1 )

dihydrofolate reductase

NC_014834
(Rhodopseudomonas palustris DX-1)

5e-22

119) Sbal175_3293
( YP_006021834.1 )

Dihydrofolate reductase

NC_017571
(Shewanella baltica BA175)

5e-22

120) Sbal223_3318
( YP_002359225.1 )

dihydrofolate reductase

NC_011663
(Shewanella baltica OS223)

5e-22

121) Dfer_4811
( YP_003089177.1 )

dihydrofolate reductase

NC_013037
(Dyadobacter fermentans DSM 18053)

5e-22

122) folA
( NP_883118.1 )

dihydrofolate reductase

NC_002928
(Bordetella parapertussis 12822)

7e-22

123) folA
( YP_006889590.1 )

dihydrofolate reductase

NC_017454
(Geobacter sulfurreducens KN400)

7e-22

124) Sputcn32_0984
( YP_001182512.1 )

dihydrofolate reductase

NC_009438
(Shewanella putrefaciens CN-32)

1e-21

125) Sputw3181_3183
( YP_964552.1 )

dihydrofolate reductase

NC_008750
(Shewanella sp. W3-18-1)

1e-21

126) folA
( NP_951629.1 )

dihydrofolate reductase

NC_002939
(Geobacter sulfurreducens PCA)

1e-21

127) folA
( YP_002924386.1 )

dihydrofolate reductase type I, trimethoprim resistance

NC_012751
(Candidatus Hamiltonella defensa T5A)

1e-21

128) PSEBR_a5358
( YP_004356865.1 )

dihydrofolate reductase

NC_015379
(Pseudomonas brassicacearum NFM421)

1e-21

129) Celf_1550
( YP_004453071.1 )

dihydrofolate reductase region

NC_015514
(Cellulomonas fimi ATCC 484)

1e-21

130) folA
( YP_006899085.1 )

dihydrofolate reductase

NC_018829
(Bordetella bronchiseptica MO149)

1e-21

131) folA
( YP_006627328.1 )

dihydrofolate reductase

NC_018518
(Bordetella pertussis 18323)

1e-21

132) folA
( YP_005591118.1 )

dihydrofolate reductase

NC_017223
(Bordetella pertussis CS)

1e-21

133) folA
( NP_881720.1 )

dihydrofolate reductase

NC_002929
(Bordetella pertussis Tohama I)

1e-21

134) folA
( YP_006968624.1 )

dihydrofolate reductase

NC_019382
(Bordetella bronchiseptica 253)

2e-21

135) Sbal117_1071
( YP_006036342.1 )

Dihydrofolate reductase

NC_017579
(Shewanella baltica OS117)

2e-21

136) Sbal_0972
( YP_001049365.1 )

dihydrofolate reductase

NC_009052
(Shewanella baltica OS155)

2e-21

137) Mext_2659
( YP_001640122.1 )

dihydrofolate reductase

NC_010172
(Methylobacterium extorquens PA1)

2e-21

138) Mchl_2886
( YP_002421653.1 )

dihydrofolate reductase

NC_011757
(Methylobacterium chloromethanicum CM4)

2e-21

139) Varpa_1813
( YP_004154134.1 )

dihydrofolate reductase region

NC_014931
(Variovorax paradoxus EPS)

2e-21

140) dfrA
( YP_002963882.1 )

dihydrofolate reductase

NC_012808
(Methylobacterium extorquens AM1)

3e-21

141) Celal_2140
( YP_004164933.1 )

dihydrofolate reductase

NC_014934
(Cellulophaga algicola DSM 14237)

3e-21

142) dfrA [H]
( YP_007216239.1 )

Dihydrofolate reductase

NC_019902
(Thioalkalivibrio nitratireducens DSM 14787)

3e-21

143) C380_08895
( YP_006854119.1 )

dihydrofolate reductase

NC_018708
(Acidovorax sp. KKS102)

3e-21

144) dfrA
( YP_003068918.1 )

dihydrofolate reductase

NC_012988
(Methylobacterium extorquens DM4)

4e-21

145) Mesil_0096
( YP_003683549.1 )

dihydrofolate reductase

NC_014212
(Meiothermus silvanus DSM 9946)

7e-21

146) folA
( YP_001906665.1 )

dihydrofolate reductase

NC_010694
(Erwinia tasmaniensis Et1/99)

7e-21

147) Echvi_2448
( YP_007224705.1 )

dihydrofolate reductase

NC_019904
(Echinicola vietnamensis DSM 17526)

7e-21

148) PputUW4_05157
( YP_007032152.1 )

dihydrofolate reductase

NC_019670
(Pseudomonas sp. UW4)

7e-21

149) folA
( YP_005951693.1 )

dihydrofolate reductase FolA

NC_017538
(Oligotropha carboxidovorans OM4)

1e-20

150) folA
( YP_004633630.1 )

dihydrofolate reductase FolA

NC_015684
(Oligotropha carboxidovorans OM5)

1e-20

151) folA
( YP_002288274.1 )

dihydrofolate reductase

NC_011386
(Oligotropha carboxidovorans OM5; ATCC 49405)

1e-20

152) folA
( YP_934700.1 )

FolA protein

NC_008702
(Azoarcus sp. BH72)

1e-20

153) folA
( YP_003537753.1 )

dihydrofolate reductase

NC_013971
(Erwinia amylovora ATCC 49946)

1e-20

154) Sde_0351
( YP_525827.1 )

dihydrofolate reductase

NC_007912
(Saccharophagus degradans 2-40)

2e-20

155) dhfrIII
( YP_006557144.1 )

dihydrofolate reductase type 3

NC_018268
(Marinobacter sp. BSs20148)

2e-20

156) folA
( YP_002647738.1 )

dihydrofolate reductase

NC_012214
(Erwinia pyrifoliae Ep1/96)

2e-20

157) Caka_1328
( YP_003548518.1 )

dihydrofolate reductase

NC_014008
(Coraliomargarita akajimensis DSM 45221)

2e-20

158) NGO1694
( YP_208730.1 )

hypothetical protein

NC_002946
(Neisseria gonorrhoeae FA 1090)

2e-20

159) folA
( YP_003532284.1 )

dihydrofolate reductase

NC_013961
(Erwinia amylovora CFBP1430)

2e-20

160) folA
( YP_005801502.1 )

protein folA

NC_017390
(Erwinia pyrifoliae DSM 12163)

2e-20

161) ambt_15520
( YP_004468416.1 )

dihydrofolate reductase type I

NC_015554
(Alteromonas sp. SN2)

3e-20

162) folA
( YP_005816954.1 )

hypothetical protein

NC_017445
(Erwinia sp. Ejp617)

4e-20

163) Shewmr7_3120
( YP_739161.1 )

dihydrofolate reductase

NC_008322
(Shewanella sp. MR-7)

4e-20

164) RPE_2177
( YP_781101.1 )

dihydrofolate reductase

NC_008435
(Rhodopseudomonas palustris BisA53)

5e-20

165) folA
( YP_001476954.1 )

dihydrofolate reductase

NC_009832
(Serratia proteamaculans 568)

5e-20

166) SPISAL_08210
( YP_008047201.1 )

dihydrofolate reductase

NC_021291
(Spiribacter salinus M19-40)

5e-20

167) folA
( YP_759193.1 )

dihydrofolate reductase

NC_008358
(Hyphomonas neptunium ATCC 15444)

6e-20

168) Shewmr4_0900
( YP_733037.1 )

dihydrofolate reductase

NC_008321
(Shewanella sp. MR-4)

7e-20

169) Thivi_0961
( YP_006413121.1 )

dihydrofolate reductase

NC_018012
(Thiocystis violascens DSM 198)

8e-20

170) folA
( YP_003627640.1 )

dihydrofolate reductase

NC_014147
(Moraxella catarrhalis RH4)

9e-20

171) folA
( YP_003467711.1 )

dihydrofolate reductase type I, trimethoprim resistance

NC_013892
(Xenorhabdus bovienii SS-2004)

1e-19

172) Shewana3_3214
( YP_870844.1 )

dihydrofolate reductase

NC_008577
(Shewanella sp. ANA-3)

1e-19

173) folA
( YP_003740079.1 )

dihydrofolate reductase

NC_014306
(Erwinia billingiae Eb661)

1e-19

174) Tmz1t_1591
( YP_002355245.1 )

dihydrofolate reductase

NC_011662
(Thauera sp. MZ1T)

1e-19

175) folA
( YP_007628070.1 )

dihydrofolate reductase

NC_020796
(Edwardsiella tarda C07-087)

2e-19

176) folA
( YP_003294655.1 )

dihydrofolate reductase

NC_013508
(Edwardsiella tarda EIB202)

2e-19

177) ETAF_0543
( YP_005698159.1 )

Dihydrofolate reductase

NC_017309
(Edwardsiella tarda FL6-60)

2e-19

178) PADK2_01755
( YP_006480348.1 )

dihydrofolate reductase

NC_018080
(Pseudomonas aeruginosa DK2)

2e-19

179) amb1326
( YP_420689.1 )

dihydrofolate reductase

NC_007626
(Magnetospirillum magneticum AMB-1)

3e-19

180) G655_01775
( YP_007707204.1 )

dihydrofolate reductase

NC_020912
(Pseudomonas aeruginosa B136-33)

3e-19

181) folA
( YP_005972939.1 )

dihydrofolate reductase

NC_017548
(Pseudomonas aeruginosa M18)

3e-19

182) folA
( YP_005984048.1 )

dihydrofolate reductase

NC_017549
(Pseudomonas aeruginosa NCGM2.S1)

3e-19

183) folA
( NP_249041.1 )

dihydrofolate reductase

NC_002516
(Pseudomonas aeruginosa PAO1)

3e-19

184) M062_01750
( YP_008130815.1 )

diacylglycerol kinase

NC_021577
(Pseudomonas aeruginosa RP73)

3e-19

185) folA
( YP_788521.1 )

dihydrofolate reductase

NC_008463
(Pseudomonas aeruginosa UCBPP-PA14)

3e-19

186) folA
( YP_061969.1 )

dihydrofolate reductase

NC_006087
(Leifsonia xyli CTCB07)

3e-19

187) M943_14275
( YP_008226858.1 )

dihydrofolate reductase

NC_021740
(Mycobacterium tuberculosis EAI5)

4e-19

188) dfrA
( YP_004724417.1 )

dihydrofolate reductase

NC_015758
(Mycobacterium africanum GM041182)

5e-19

189) dfrA
( NP_856431.1 )

dihydrofolate reductase

NC_002945
(Mycobacterium bovis AF2122/97)

5e-19

190) dfrA
( YP_978866.1 )

dihydrofolate reductase dfrA

NC_008769
(Mycobacterium bovis BCG Pasteur 1173P2)

5e-19

191) K60_028580
( YP_007431916.1 )

dihydrofolate reductase dfrA

NC_020245
(Mycobacterium bovis Korea 1168P)

5e-19

192) dfrA
( YP_005172230.1 )

putative dihydrofolate reductase

NC_016804
(Mycobacterium bovis Mexico)

5e-19

193) dfrA
( YP_002645823.1 )

dihydrofolate reductase

NC_012207
(Mycobacterium bovis Tokyo 172)

5e-19

194) dfrA
( YP_004746217.1 )

dihydrofolate reductase DFRA

NC_015848
(Mycobacterium canettii CIPT 140010059)

5e-19

195) dfrA
( YP_007261509.1 )

Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

NC_019950
(Mycobacterium canettii CIPT 140060008)

5e-19

196) dfrA
( YP_007288708.1 )

Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

NC_019965
(Mycobacterium canettii CIPT 140070008)

5e-19

197) dfrA
( YP_007265490.1 )

Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

NC_019951
(Mycobacterium canettii CIPT 140070010)

5e-19

198) dfrA
( YP_007269450.1 )

Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

NC_019952
(Mycobacterium canettii CIPT 140070017)

5e-19

199) MT7199_2796
( YP_007352533.1 )

DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)

NC_020089
(Mycobacterium tuberculosis 7199-99)

5e-19

200) J112_14800
( YP_007855771.1 )

dihydrofolate reductase

NC_021054
(Mycobacterium tuberculosis Beijing/NITR203)

5e-19

201) J113_19165
( YP_007962638.1 )

dihydrofolate reductase

NC_021193
(Mycobacterium tuberculosis CAS/NITR204)

5e-19

202) CCDC5079_2534
( YP_005913957.1 )

dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase)

NC_017523
(Mycobacterium tuberculosis CCDC5079)

5e-19

203) dfrA
( YP_008007755.1 )

dihydrofolate reductase

NC_021251
(Mycobacterium tuberculosis CCDC5079)

5e-19

204) CCDC5180_2504
( YP_005910336.1 )

dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase)

NC_017522
(Mycobacterium tuberculosis CCDC5180)

5e-19

205) folA
( NP_337338.1 )

dihydrofolate reductase

NC_002755
(Mycobacterium tuberculosis CDC1551)

5e-19

206) dfrA
( YP_005917843.1 )

dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate dehydrogenase)

NC_017524
(Mycobacterium tuberculosis CTRI-2)

5e-19

207) J114_14740
( YP_007966679.1 )

dihydrofolate reductase

NC_021194
(Mycobacterium tuberculosis EAI5/NITR206)

5e-19

208) dfrA
( YP_007611485.1 )

dihydrofolate reductase

NC_020559
(Mycobacterium tuberculosis Erdman (ATCC35801))

5e-19

209) TBFG_12776
( YP_001288705.1 )

dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase)

NC_009565
(Mycobacterium tuberculosis F11)

5e-19

210) dfrA
( YP_001284128.1 )

dihydrofolate reductase

NC_009525
(Mycobacterium tuberculosis H37Ra)

5e-19

211) dfrA
( NP_217279.1 )

Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

NC_000962
(Mycobacterium tuberculosis H37Rv)

5e-19

212) RVBD_2763c
( YP_006516208.1 )

dihydrofolate reductase

NC_018143
(Mycobacterium tuberculosis H37Rv)

5e-19

213) TBHG_02695
( YP_002159720.2 )

dihydrofolate reductase DfrA

NC_022350
(Mycobacterium tuberculosis Haarlem)

5e-19

214) TBMG_01212
( YP_003031156.1 )

dihydrofolate reductase dfrA

NC_012943
(Mycobacterium tuberculosis KZN 1435)

5e-19

215) TBSG_01222
( YP_005099690.1 )

dihydrofolate reductase dfrA

NC_016768
(Mycobacterium tuberculosis KZN 4207)

5e-19

216) TBXG_001202
( YP_006472675.1 )

dihydrofolate reductase dfrA

NC_018078
(Mycobacterium tuberculosis KZN 605)

5e-19

217) MRGA423_17145
( YP_005923916.1 )

dihydrofolate reductase

NC_017528
(Mycobacterium tuberculosis RGTB423)

5e-19

218) dfrA
( YP_005309024.1 )

hypothetical protein

NC_016934
(Mycobacterium tuberculosis UT205)

5e-19

219) O159_15960
( YP_008580218.1 )

dihydrofolate reductase

NC_022438
(Leifsonia xyli DSM 46306)

1e-18

220) folA
( YP_005932902.1 )

dihydrofolate reductase FolA

NC_017531
(Pantoea ananatis AJ13355)

1e-18

221) folA
( YP_003518975.1 )

FolA

NC_013956
(Pantoea ananatis LMG 20103)

1e-18

222) folA
( YP_005197061.1 )

dihydrofolate reductase type I

NC_016816
(Pantoea ananatis LMG 5342)

1e-18

223) PAGR_g3518
( YP_005994230.1 )

dihydrofolate reductase FolA

NC_017554
(Pantoea ananatis PA13)

1e-18

224) Dsui_1240
( YP_005027481.1 )

dihydrofolate reductase

NC_016616
(Dechlorosoma suillum PS)

2e-18

225) D781_0673
( YP_007343206.1 )

dihydrofolate reductase

NC_020064
(Serratia marcescens FGI94)

4e-18

226) I917_19365
( YP_007958771.1 )

dihydrofolate reductase

NC_021192
(Mycobacterium tuberculosis Haarlem/NITR202)

5e-18

227) Mycsm_02511
( YP_007292251.1 )

dihydrofolate reductase

NC_019966
(Mycobacterium smegmatis JS623)

1e-17

228) RPC_3263
( YP_533124.1 )

dihydrofolate reductase

NC_007925
(Rhodopseudomonas palustris BisB18)

1e-17

229) folA
( YP_003714179.1 )

dihydrofolate reductase

NC_014228
(Xenorhabdus nematophila ATCC 19061)

1e-17

230) dfrA
( YP_004523763.1 )

dihydrofolate reductase DfrA

NC_015576
(Mycobacterium sp. JDM601)

1e-17

231) folA
( YP_006350571.1 )

dihydrofolate reductase

NC_017941
(Haloferax mediterranei CGMCC 1.2087)

1e-17

232) folA
( YP_008136799.1 )

dihydrofolate reductase FolA

NC_021591
(Serratia odorifera 4Rx13)

1e-17

233) folA
( YP_008157463.1 )

dihydrofolate reductase

NC_021659
(Serratia plymuthica S13)

1e-17

234) Dd586_3577
( YP_003335113.1 )

Dihydrofolate reductase

NC_013592
(Dickeya dadantii Ech586)

2e-17

235) NMBM01240355_0319
( YP_005900995.1 )

dihydrofolate reductase

NC_017517
(Neisseria meningitidis M01-240355)

2e-17

236) Hmuk_1491
( YP_003177313.1 )

dihydrofolate reductase subunit

NC_013202
(Halomicrobium mukohataei DSM 12286)

5e-17

237) folA
( YP_005040395.1 )

dihydrofolate reductase

NC_016622
(Azospirillum lipoferum 4B)

5e-17

238) MycrhN_5637
( YP_005003320.1 )

dihydrofolate reductase

NC_016604
(Mycobacterium rhodesiae NBB3)

7e-17

239) folA
( YP_005282475.1 )

dihydrofolate reductase FolA

NC_016906
(Gordonia polyisoprenivorans VH2)

9e-17

240) NGK_2087
( YP_002002712.1 )

protein FolA

NC_011035
(Neisseria gonorrhoeae NCCP11945)

1e-16

241) folA
( YP_007347141.1 )

dihydrofolate reductase

NC_020075
(Candidatus Blochmannia chromaiodes 640)

1e-16

242) Pfl01_5361
( YP_351089.1 )

dihydrofolate reductase

NC_007492
(Pseudomonas fluorescens Pf0-1)

1e-16

243) folA
( YP_007404532.1 )

dihydrofolate reductase

NC_020211
(Serratia marcescens WW4)

2e-16

244) folA
( YP_003002920.1 )

dihydrofolate reductase

NC_012912
(Dickeya zeae Ech1591)

2e-16

245) folA
( YP_005892674.1 )

dihydrofolate reductase

NC_017512
(Neisseria meningitidis WUE 2594)

1e-15

246) NMA2179
( YP_002343426.1 )

dihydrofolate reductase

NC_003116
(Neisseria meningitidis Z2491)

1e-15

247) NMBB_0341
( YP_005881971.1 )

dihydrofolate reductase

NC_017505
(Neisseria meningitidis alpha710)

1e-15

248) NMBH4476_0303
( YP_005899014.1 )

dihydrofolate reductase

NC_017516
(Neisseria meningitidis H44/76)

1e-15

249) NMBM01240149_1775
( YP_005896534.1 )

dihydrofolate reductase

NC_017514
(Neisseria meningitidis M01-240149)

1e-15

250) folA
( YP_005897079.1 )

dihydrofolate reductase

NC_017515
(Neisseria meningitidis M04-240196)

1e-15

251) folA
( NP_273358.1 )

dihydrofolate reductase

NC_003112
(Neisseria meningitidis MC58)

1e-15

252) folA
( YP_005904485.1 )

dihydrofolate reductase

NC_017518
(Neisseria meningitidis NZ-05/33)

1e-15

253) Swit_3786
( YP_001264269.1 )

dihydrofolate reductase

NC_009511
(Sphingomonas wittichii RW1)

1e-15

254) folA
( YP_003083877.1 )

Dihydrofolate reductase

NC_013016
(Neisseria meningitidis alpha14)

1e-15

255) folA
( YP_004047995.1 )

dihydrofolate reductase

NC_014752
(Neisseria lactamica 020-06)

1e-15

256) folA
( YP_001599935.1 )

dihydrofolate reductase

NC_010120
(Neisseria meningitidis 053442)

1e-15

257) NMBG2136_1790
( YP_005894627.1 )

dihydrofolate reductase

NC_017513
(Neisseria meningitidis G2136)

2e-15

258) folA
( YP_975807.1 )

dihydrofolate reductase

NC_008767
(Neisseria meningitidis FAM18)

3e-15

259) folA
( YP_005030179.1 )

dihydrofolate reductase

NC_016617
(Azospirillum brasilense Sp245)

3e-15

260) folA
( YP_005877887.1 )

dihydrofolate reductase

NC_017501
(Neisseria meningitidis 8013)

8e-15

261) Saro_3262
( YP_498531.1 )

dihydrofolate reductase

NC_007794
(Novosphingobium aromaticivorans DSM 12444)

2e-14

• Sequence Alignments

1) A225_R1p0770 in NC_018107


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  273 bits (1023),  Expect = 3e-75, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165
            SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

2) N559_5185 in NC_022078


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  273 bits (1023),  Expect = 3e-75, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165
            SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

3) tri in NC_006856


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  273 bits (1023),  Expect = 3e-75, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165
            SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

4) STMDT12_L00660 in NC_016861


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  273 bits (1023),  Expect = 3e-75, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165
            SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

5) STU288_1p00755 in NC_021155


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  273 bits (1023),  Expect = 3e-75, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165
            SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

6) KPHS_p300720 in NC_016839


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  232 bits (865),  Expect = 9e-63, Method: Compositional matrix adjust.
 Identities = 139/143 (98%), Positives = 140/143 (98%), Gaps = 0/143 (0%)

Query  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60
            MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120
            PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFEGDAFFPMLNEQNSSL  143
            SEVHQTFEGDAFFPMLNE +  L
Sbjct  121  SEVHQTFEGDAFFPMLNETEFEL  143

7) Hneap_1653 in NC_013422


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  224 bits (834),  Expect = 3e-60, Method: Compositional matrix adjust.
 Identities = 131/165 (80%), Positives = 153/165 (93%), Gaps = 0/165 (0%)

Query  1    MNQQAVRIYLVAAMGSNRVIGNGSNIPWRIPGEQKIFRTLTEGKVVVMGRKTFESIGKPL  60
            MN ++VRIYLVAAMG+NRVIGNG+NIPW+IPGEQKIFR LTEGKVVVMGRKTFESIGKPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PNRHTVVISRQTHYLAPGCTVattlaqaiaiaaeaGKDLYVAGGAEIYALAMPHAHGIFL  120
            PNRHT+VISRQ++Y A GC V +TL++AIA+A+E G++LYVAGGAEIY+LA+PHAHG+FL
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVHQTFDGDAFFPKLDEKDFELVSSETIQAAIPYTYSVYERRNG  165
            SEVHQTF+GDAFFP L+E +FELVS+ETIQA IPYT SVY RRNG
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

8) MCCL_plsB0051 in NC_011996


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  145 bits (532),  Expect = 2e-36, Method: Compositional matrix adjust.
 Identities = 73/155 (48%), Positives = 114/155 (74%), Gaps = 1/155 (0%)

Query  5    LIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTIIIS  64
            L+AA+++N VIG++ +IPWKIPGEQ  F+ LT GK V+MGRKTFESIG+PLPNR T++IS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   KSKDINYNNCLTVESLERAFNLLQQ-EDEIFIAGGGEIYKESLPFADRIYLTIIEKEYEG  123
            +  +     C+ V +L +A+ L  +  +E+++AGG+EIY  +LP A+ ++L+ +++ +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  NIFFPMFNKDEFEITYQQKVEGFIPYTYFTYERKN  158
            + FFPM+N  EFE+   + +++ IPYT   Y R+N
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYTHSVYARRN  164

9) Gura_0932 in NC_009483


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  140 bits (514),  Expect = 5e-35, Method: Compositional matrix adjust.
 Identities = 73/156 (47%), Positives = 110/156 (71%), Gaps = 2/156 (1%)

Query  5    LIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNIIIT  64
            L+AAM+ NRVIG    IPW IP+++K FR LT G  V+MGRKTFES++ PLP R  ++I+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQMDYRAEGCFIAHDLASALAMAGE-TDEIFICGGGEIYRQALPIADRIYLTIIHSRFDG  123
            RQ +YRA GC +   L+ A+A+A+E  +E+++ GG+EIY  ALP A+ ++L+ +H  F+G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTRFPEIPER-FVEVGRETVENAIPYSFVLYDKRPS  158
            D+ FP + E  F  V+ ET++  IPY+  +Y +R +
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

10) Geob_1750 in NC_011979


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  135 bits (494),  Expect = 2e-33, Method: Compositional matrix adjust.
 Identities = 69/147 (47%), Positives = 108/147 (74%), Gaps = 2/147 (1%)

Query  5    LIAAMSENRVIGDKNTIPWDLPADRKRFRSLTLGHPVIMGRKTFESIGFPLDGRKNIIVT  64
            L+AAM+ NRVIG+   IPW +P+++K FR LT G  V+MGRKTFESIG PL  R  ++++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQKDYQARGCLVAHDLPAAIKLAGDV-EEIFICGGGDIYRQALPLANRIYLTVIHQVYEG  123
            RQ +Y+A GC+V   L+ AI LA+++ +E+++ GG++IY  ALP A+ ++L+ +HQ +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTYFPKITE-EFVEVESNTADNLPSYT  149
            D++FP + E EF  V ++T + + +YT
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYT  156

11) Clocel_0240 in NC_014393


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  129 bits (471),  Expect = 1e-31, Method: Compositional matrix adjust.
 Identities = 65/155 (42%), Positives = 106/155 (69%), Gaps = 1/155 (0%)

Query  4    LIVAVAKNNVIGNNGIIPWKIKGEQKRFKELTIGKTIIMGRKSFEEIGKPLPNRKTILIS  63
            L+ A++ N VIGN   IPWKI GEQK F+ LT GK ++MGRK+FE IGKPLPNR T++IS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   NTQCIESENCTTVNSLSEAFDLTKD-EDEVFVAGGGQVYKESFTYADRIYITVIDKIIDG  122
                  +  C  V++LS+A+ L+ +  +E++VAGG+++Y  ++  A+ ++++ +++ ++G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  NVYFPEISSDDFIKSYEERIDAEIPYTYYTYERRK  157
            + +FP ++  +F     E I+A IPYT   Y RR+
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYTHSVYARRN  164

12) Fjoh_1468 in NC_009441


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  129 bits (473),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 65/158 (42%), Positives = 107/158 (68%), Gaps = 5/158 (3%)

Query  4    MIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHIIIT  63
            ++AA++ N  +G+  ++ W +P + K F+ LT    ++MGRKTFES+ KPLPNR  ++I+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQTDYNPEGCIVVDSMEKAIAACPE-NEDSYIIGGGEIYNLGLPYADIIEITKVHHTFEG  122
            RQ++Y + GC+VV ++  AIA  +E  ++ Y+ GG+EIY L+LP A+ + ++ VH+TFEG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK  160
            DAFFP ++ +E +LV +E      + +  YT   Y R+
Sbjct  130  DAFFPMLNETEFELVSTETI----QAVIPYTHSVYARR  163

13) SSUBM407_0957 in NC_012926


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  128 bits (469),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 64/155 (42%), Positives = 105/155 (68%), Gaps = 1/155 (0%)

Query  4    LIVAVAKNNVIGNNGVIPWKIKGEQKRFKELTIGKTIIMGRKSFEEIGKPLPNRKTILIS  63
            L+ A++ N VIGN   IPWKI GEQK F+ LT GK ++MGRK+FE IGKPLPNR T++IS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   NTQCIESENCATVKSLSEAFDLTKD-EDEVFVAGGGQVYKESFTYADRIYITVIDKIIDG  122
                  +  C  V +LS+A+ L+ +  +E++VAGG+++Y  ++  A+ ++++ +++ ++G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  NVYFPEISSDDFVKSYEERIEGEIPYTYYTYERRK  157
            + +FP ++  +F     E I++ IPYT   Y RR+
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYTHSVYARRN  164

14) Mar181_0627 in NC_015559


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  126 bits (461),  Expect = 8e-31, Method: Compositional matrix adjust.
 Identities = 74/165 (45%), Positives = 115/165 (70%), Gaps = 9/165 (5%)

Query  4    LIVAMSTNRTIGINNSLPWHLPNDLKYFKQATMGKPIVMGRKTFESIGKPLPGRRNIVIT  63
            L+ AM++NR IG   ++PW +P + K F++ T GK +VMGRKTFESIGKPLP R+ +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RDANYQADGIDVVSSLEQAISLGEDICLVDGQEEVMVIGGAQIYELALPKADRLYITHVD  123
            R+ANY+A G  VVS+L +AI+L+ ++      +E+ V GGA+IY LALP A+ +++++V+
Sbjct  70   RQANYRATGCVVVSTLSHAIALASEL-----GNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  124  AEVNGDAFFPEVDWPSFTVMAEESFAAEGPNPYDYRFSVYQRTSA  168
               +GDAFFP ++   F +++ E++ A  P    Y  SVY R ++
Sbjct  125  QTFEGDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

15) Mmwyl1_3741 in NC_009654


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  124 bits (452),  Expect = 4e-30, Method: Compositional matrix adjust.
 Identities = 73/165 (45%), Positives = 113/165 (69%), Gaps = 9/165 (5%)

Query  4    LIVAMSTNRTIGINNSLPWHLPNDLKYFKQATMGKPIVMGRKTFESIGKPLPGRRNIVIS  63
            L+ AM++NR IG   ++PW +P + K F++ T GK +VMGRKTFESIGKPLP R+ +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RDPTYQAEGIDVVTTLEDAISLGEDICLVNGQEEVMVIGGAQIYQLALERADRLYITHVD  123
            R++ Y+A G  VV+TL +AI+L+ ++      +E+ V GGA+IY LAL +A+ +++++V+
Sbjct  70   RQANYRATGCVVVSTLSHAIALASEL-----GNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  124  AEVKGDAFFPEVDWPSFTLIGEEAFAAEGPNPYDYRFSVYQRTSA  168
                GDAFFP ++   F L++ E++ A  P    Y  SVY R ++
Sbjct  125  QTFEGDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

16) dfrA in NC_002570


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  124 bits (453),  Expect = 4e-30, Method: Compositional matrix adjust.
 Identities = 65/158 (42%), Positives = 109/158 (69%), Gaps = 5/158 (3%)

Query  4    FIVAMDKHRLIGKENDLPWRLPADLAHFKRVTSGHTVIMGRKTYESIGKPLPNRRNVVVT  63
            ++ AM+ +R+IG+  ++PW++P++   F+R+T G  V+MGRKT+ESIGKPLPNR+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RSQAYTAEGVDIVHSIDEAIRL-TEHENETFVIGGSELFKAFWPHADRMYVTYIDEVFDG  122
            R   Y A G  +V ++ +AI L +E  NE +V GG+E++    PHA+ ++++ +++ F+G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTYFPEIDGQEWELVSVEAGTIDEKNVYPHEFRVYERQ  160
            D++FP ++  E ELVS E  TI+    Y H   VY R+
Sbjct  130  DAFFPMLNETEFELVSTE--TIQAVIPYTHS--VYARR  163

17) dfrD_2 in NC_021994


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  123 bits (448),  Expect = 8e-30, Method: Compositional matrix adjust.
 Identities = 66/156 (43%), Positives = 107/156 (69%), Gaps = 3/156 (1%)

Query  4    LIVARSKNNVIGKNGNIPWKIKGEQKQFRELTTGNVVIMGRKSYEEIGHPLPNRMNIVVS  63
            L+ A + N VIG+  NIPWKI GEQK FR LT G+VV+MGRK++E IG PLPNR  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   TTTEYQGDNLVSVKSLEDALLLAK--GRDVYISGGYGLFKEALQIVDKMYITEVDLNIED  121
              ++Y++   V V +L +A+ LA   G ++Y++GG  ++  AL   + ++++EV+  +E 
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE-  128

Query  122  GDTFFPEFDINDFEVLIGETLGEEVKYTRTFYVRKK  157
            GD+FFP ++  +FE++  ET+   + YT++ Y R++
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRN  164

18) Marme_0712 in NC_015276


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  122 bits (446),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 67/163 (42%), Positives = 114/163 (70%), Gaps = 9/163 (5%)

Query  4    LIVAMSTNRVIGINNALPWHLPNDLKYFKQATMGKPIIMGRNTFESIGKPLPGRRNIVIT  63
            L+ AM++NRVIG    +PW +P + K F++ T GK ++MGR+TFESIGKPLP R+ +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RNPDYKADGVDVVGSLDQAIQLGEDICLVNGHEEVMIIGGSQIYDLALSRADRLYITHVD  123
            R+++Y+A G  VV++L +AI L+ ++      +E+ + GG++IY LAL++A+ +++++V+
Sbjct  70   RQANYRATGCVVVSTLSHAIALASEL-----GNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  124  AHVEGDAFFPEVDWSGYEKIAEEGFEASGHNPYDYRFSVYQQR  166
               EGDAFFP ++ + +E ++ E ++A       Y  SVY +R
Sbjct  125  QTFEGDAFFPMLNETEFELVSTETIQAV----IPYTHSVYARR  163

19) Slin_1051 in NC_013730


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  120 bits (439),  Expect = 4e-29, Method: Compositional matrix adjust.
 Identities = 63/141 (45%), Positives = 104/141 (74%), Gaps = 1/141 (0%)

Query  1    MKISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTN  60
            ++I L+AA++ N VIG   ++PW +P++  +F+R T    ++MGRK++ES+GKPLPNR  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIH  120
            +V++R+A++ A+G  +V TL +AIA A  + + E++V GGAEIY +ALP A  ++L+E+H
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGN-ELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  QDYDGDAYFPEFDKNEWQEVS  141
            Q ++GDA+FP ++  E + VS
Sbjct  125  QTFEGDAFFPMLNETEFELVS  145

20) Weevi_0641 in NC_015144


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  120 bits (440),  Expect = 4e-29, Method: Compositional matrix adjust.
 Identities = 68/158 (44%), Positives = 105/158 (67%), Gaps = 4/158 (2%)

Query  4    LVVAIASNHAIGKGNQMLWHLPKDFLHFKKITTGHPIIMGRKTFESIGRPLPNRVNIVIS  63
            LV A+++N+ IG+G ++ W +P +   F+++T G  ++MGRKTFESIG+PLPNR  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RDRNYSADGIQVVHSLREAIEKGYKLDEDLYVIGGGEIYRQAMEFADKIYLTEVHHEFEG  123
            R+ NY A G  VV +L +AI  +  L+++LYV GG+EIY  A+  A+ ++L+EVH+ FEG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTFFPEIDDEKWVEVDREHHLKDDKHLYSYDFVEYLRR  161
            D+FFP +++     V  E      + + +Y    Y RR
Sbjct  130  DAFFPMLNETEFELVSTE----TIQAVIPYTHSVYARR  163

21) STH3116 in NC_006177


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  120 bits (438),  Expect = 5e-29, Method: Compositional matrix adjust.
 Identities = 70/155 (46%), Positives = 99/155 (64%), Gaps = 8/155 (5%)

Query  1    MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG  60
            MG NR IG    +PW++P+E + FRR T GK VVMGR+T+ESIG PL  R  +V++R++ 
Sbjct  14   MGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQAN  73

Query  61   FRAPGCEV----RHSVAELLQDRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFF  116
            +RA GC V     H++A   +    LYV GGAE+Y   LPHA+ ++L+ +++ FEGDAFF
Sbjct  74   YRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFF  133

Query  117  PAWSEDEWELVGSTPHPRDEENPYDFVVEHYRRRR  151
            P  +E E ELV++  +  +   PY   V  Y RR 
Sbjct  134  PMLNETEFELVST--ETIQAVIPYTHSV--YARRN  164

22) Oweho_2962 in NC_016599


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  119 bits (435),  Expect = 1e-28, Method: Compositional matrix adjust.
 Identities = 57/136 (42%), Positives = 99/136 (73%), Gaps = 1/136 (0%)

Query  5    IIAAMAKGRVIGKDNDLIWHLPDDLKHFKNLTKGHHVIMGRKTYQSMGKPLPGRTNIVIT  64
            ++AAM+  RVIG++ ++ W +P++ K F+ LT G  V+MGRKT++S+GKPLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQKDFKADGCILVNNIEEGIQ-KAEGDSQPFIIGGGEIYKQALKYAQTMELTEVNGEFDG  123
            RQ +++A GC++V+ + ++I   +E +++ ++ GG+EIY  AL  A+ + L+EV+  F+G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTFFPTFDEKQWKEVS  139
            D+FFP ++E +   VS
Sbjct  130  DAFFPMLNETEFELVS  145

23) Tbd_2039 in NC_007404


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  119 bits (434),  Expect = 1e-28, Method: Compositional matrix adjust.
 Identities = 66/161 (41%), Positives = 110/161 (69%), Gaps = 5/161 (3%)

Query  8    RVSVIAALAKNRVIGIENRLPWRLPEDLAHFKALTLDHPVLMGRKTFESLGRPLPRRTNV  67
            R+ ++AA++ NRVIG    +PW++P +   F+ LT +  V+MGRKTFES+G+PLP R  +
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  68   VITRNADYRPDGCLVAASMPAAIAL-CQGADEIFFIGGAELYAQAIPLADRLYLTEVDAE  126
            VI+R+A+YR+ GC+V ++++ AIAL  + ++E++  GGAE+Y+ A+P A+ ++L+EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  127  PEGDAWFPEFDRAAFREISRASHVGEKGDVLRFDFVVYERR  167
             EGDA FP ++ + F  +S  +       V+ +   VY RR
Sbjct  127  FEGDAFFPMLNETEFELVSTET----IQAVIPYTHSVYARR  163

24) Bxe_B1926 in NC_007952


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (431),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 71/156 (46%), Positives = 109/156 (70%), Gaps = 3/156 (1%)

Query  6    RVVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLL  65
            R+ LVAAM+ANRVIG G +IPW+IPGEQK FR LT  ++VVMGR+TFESIGKPLP R+ L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  66   VLSSGTS-RLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDL  124
            V+S  ++ R      V ++++ + A+ ++  + ++V+GG ++Y++ +P A+ V+L+E++ 
Sbjct  67   VISRQANYRATGCVVVSTLSH-AIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  125  RPPGDAFFPEIPER-FSLPDSVDFPGEIRYTFNTYA  159
               GDAFFP + E  F L  +  + + I YT + YA
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYA  161

25) Pjdr2_2656 in NC_012914


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (431),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 75/165 (46%), Positives = 111/165 (68%), Gaps = 7/165 (4%)

Query  1    MSITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTN  60
            + I ++AAM+  R IG G ++PW++P+E   F R T GK VVMGRKTFES+ KPL +R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   VVITRQPEYAKEGCEVVHSVQEAIDRYGE--GELMVIGGADIYAQFLPFADKIRLTEVDT  118
            +VI+RQ++Y   GC VV ++ +AI   +E   EL V GGA+IY+  LP A+ + L+EV+ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  119  NIEGGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARRNA  163
             +E GDAFFP +NE E E V +E +++     +++T   +ARRN+
Sbjct  126  TFE-GDAFFPMLNETEFELVSTETIQA----VIPYTHSVYARRNG  165

26) EUBELI_01781 in NC_012778


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (429),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 60/140 (43%), Positives = 101/140 (73%), Gaps = 3/140 (2%)

Query  4    LIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNIIVS  63
            L+ A + N VIG   +IPWKI GEQK+F+ LT G++VVMGRK++E IG PLPNR+ +++S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   KTMKYEGENLITVSSLAEALALSDN--SNIYIAGGYGVYKEAIPFVDVMYITEVDMNIED  121
            +  +Y +   + VS+L++A+AL+ +  +++Y+AGG  +Y  A+P  + ++++EV+  +E 
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE-  128

Query  122  GDVFFPEFDVNDFDLIIGET  141
            GD FFP ++  +F+L+  ET
Sbjct  129  GDAFFPMLNETEFELVSTET  148

27) B565_0876 in NC_015424


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (432),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 67/163 (42%), Positives = 116/163 (72%), Gaps = 5/163 (3%)

Query  1    MKISMIAAMAHDRVIGKDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRN  60
            ++I ++AAM+ +RVIG++ ++PW +P++   F+R+T GK V+MGRKTFESIG+PLP R+ 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   LVISRNPDYQAEGIEVVGSVEAALALLAGSLVEELMVIGGGHLYAEMLPSADCLYLTRID  120
            LVISR+++Y+A G  VV+++  A+A LA+ L +EL V GG+++Y+  LP A+ ++L+ ++
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIA-LASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LAVEGDTRFPAFDDGQWQRIACESHPADEKNPHPYSFETWQRR  163
             + EGD+ FP +++ + + ++ E+  A      PY+     RR
Sbjct  125  QTFEGDAFFPMLNETEFELVSTETIQA----VIPYTHSVYARR  163

28) Lcho_1259 in NC_010524


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (431),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 60/146 (42%), Positives = 104/146 (72%), Gaps = 4/146 (2%)

Query  2    TRIVLIAAVARNGVIGRDNDLPWRLPEDLQFFRRTTMGHPVLMGRRNWDSLPAKFRPLPG  61
             RI L+AA++ N VIG + ++PW++P + ++FRR T G  V+MGR+  +S+    +PLP 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPN  62

Query  62   RHNLVLTRNPDWRAEGATVVHSLAQALDQLGDVPT-LFVIGGGELYRLALPLADEIILTE  120
            RH LV++R+++ RA G  VV +L++A+   +++   L+V GG+E+Y LALP A+ ++L+E
Sbjct  63   RHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSE  122

Query  121  IDRAVDGDVFFPHWDRSAFEVLSRET  146
            ++++ +GD FFP  + + FE++S ET
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTET  148

29) folA in NC_018691


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  118 bits (431),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 69/170 (41%), Positives = 116/170 (69%), Gaps = 9/170 (5%)

Query  5    NEQGVRVAMIVAMARNRVIGRDNKLPWYLPNDLKYFKRTTLGKPVVMGRLTWESLGRPLP  64
            N ++VR+ ++ AM+ NRVIG + ++PW +P + K F+R T GK VVMGR T ES+G+PLP
Sbjct  2    NSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLP  61

Query  65   GRTNIVISRDPHYQAEGAKVVADLDQALELAGNVAFIDGQDEVMILGGAQIYALALPRAD  124
             R  +VISR+++Y+A G  VV+ L +A+ LA++++     +E+ + GGA+IY+LALP+A+
Sbjct  62   NRHTLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAH  116

Query  125  RLYITEVQADVDGDAWFPRWDRSQWVERGRESFKAEGPNPYDYDFVVFDR  174
             ++++EV+   +GDA FP  + ++    + E+++A  P    Y   V+ R
Sbjct  117  GVFLSEVHQTFEGDAFFPMLNETEFELVSTETIQAVIP----YTHSVYAR  162

30) folA in NC_008260


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  117 bits (428),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 68/168 (41%), Positives = 113/168 (68%), Gaps = 9/168 (5%)

Query  4    SIRLSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRT  63
            S+R+ ++ A ++N VIG   ++PW +P + K F+++T GK V+MGRKT ES+  PLP R 
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRH  64

Query  64   NIVITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLY  123
             +VI+RQ+ Y+A G  VV+T+ +AI++A +++     +E  + GGAEIY+LAL++++ ++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVF  119

Query  124  LTEVHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK  171
            L+EVH   +GD+FFP  +  E E ++ E + A  P    Y+  VY R+
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARR  163

31) folA in NC_007517


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  117 bits (426),  Expect = 4e-28, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 107/158 (68%), Gaps = 2/158 (1%)

Query  3    VTIIAAMAGNRVIGKEGAMPWHLPDDLARFKAITMGHPVVMGRKTFESIGRPLPGRLNIV  62
            + ++AAM++NRVIG+   +PW +P++   F+ +T G  VVMGRKTFESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LTRQAGYAPSGVTVARTLAEALILAGTAG-EVFICGGGEVYREALPLADRIHLTVIHRAY  121
            ++RQA Y ++G  V  TL++A+ LA+  G E+++ GG+E+Y  ALP A+ + L+ +H+++
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  GGDTTFPELP-ADFEETCREHGEGKPPHSFITFERRRG  158
             GD+ FP L  ++FE    E  ++  P +   + RR G
Sbjct  128  EGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG  165

32) folA in NC_009348


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  116 bits (422),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 68/164 (42%), Positives = 111/164 (68%), Gaps = 6/164 (3%)

Query  1    MKISMIAAMAHDRVIGLDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRN  60
            ++I ++AAM+ +RVIG + ++PW +P++   F+R+T GK V+MGRKTFESIG+PLP R+ 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   LVISRNPDYRADGVEVVDSVEAALMLLANAGNVDELMVIGGGHLYGQLLPQANSLYLTRI  120
            LVISR+++YRA G  VV ++  A+ L ++ GN  EL V GG+++Y   LP+A++++L+ +
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGN--ELYVAGGAEIYTLALPHAHGVFLSEV  123

Query  121  DLAVAGDTCFPAFEEDEWHCVEREPHEPDEKNPHPYCFETWQRR  164
            + +  GD+ FP ++E E + V  E  ++      PY      RR
Sbjct  124  HQTFEGDAFFPMLNETEFELVSTETIQA----VIPYTHSVYARR  163

33) Phep_1421 in NC_013061


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  115 bits (419),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 58/142 (41%), Positives = 94/142 (67%), Gaps = 1/142 (0%)

Query  5    IVVAIAENNAIGKNNELLWHLPTDLKHFKQLTSGHTIIMGRKTFDSIGKPLPNRRNIVIT  64
            +V A++ N  IG+  ++ W +P + K F++LT G  ++MGRKTF+SIGKPLPNR+ +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RSNSLEIPGAEVVNNIDQALALCTA-EKEVFIVGGAEIYRQAMDKTDKIYLTTVHAGFEG  123
            R  +    G  VV+ + +A+AL +   +E+++ GGAEIY  A+  ++ ++L+ VH  FEG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DAYFPEIDRKKWEEVDNEPHQP  145
            DA+FP ++    E V  E  Q+
Sbjct  130  DAFFPMLNETEFELVSTETIQA  151

34) TKWG_20480 in NC_017964


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (417),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 69/157 (44%), Positives = 97/157 (62%), Gaps = 2/157 (1%)

Query  17   IILVAYAIENRAIGVNNTLPWHLPGDLKRFKTLTMGKPIIMGRKTWESIGRPLPGRRNIV  76
            I LVA    NR IG    +PW +PG+ K F+ LT GK ++MGRKT ESIG+PLP R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  77   ITRRQDLSIEGADVVNSLDAAIALAFEQGDTAFVIGGEQIYAQAIEKSQQVMATEIHQFV  136
            I+R+ +    G  VV++L  AIALA E G+  +V GG +IY+ A+  ++ V  +E+HQ  
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  137  DGDAFFPDLDEKLWRETSRDTQPEENGMNYDYVVYER  173
            +GDAFFP L+E      S  T+  +  + Y   VY R
Sbjct  128  EGDAFFPMLNETEFELVS--TETIQAVIPYTHSVYAR  162

35) Krodi_0787 in NC_015496


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (417),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 60/137 (44%), Positives = 97/137 (71%), Gaps = 1/137 (0%)

Query  4    MIAAAAENNALGKDGNIPWHLPDDFRHFKQLTTGHHIIMGRKTWESFPKPLPNRTHIVIT  63
            ++AA + N  +G++ NIPW +P++ + F++LT G  ++MGRKT ES+ KPLPNR  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RDVNYKAENAIVVHSLEDALAYSKD-EAHTYIIGGGEIYKLGMDYATHIELTRVHNEFEA  122
            R+ NY+A   +VV +L +A+A + +   + Y+ GG+EIY L++  A  + L+ VH+ FE+
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DAFFPEINTNQWELVSS  139
            DAFFP +N  + ELVS+
Sbjct  130  DAFFPMLNETEFELVST  146

36) Metme_4551 in NC_015572


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (415),  Expect = 3e-27, Method: Compositional matrix adjust.
 Identities = 54/132 (41%), Positives = 96/132 (73%), Gaps = 1/132 (0%)

Query  1    MKISLIVAMASNRVIGLNGMMPWHLSADLKRFKQITLGSPIMMGRKTFDAIGRPLPGREN  60
            ++I L+ AM++NRVIG    +PW ++++ K F+++T G  ++MGRKTF++IG+PLP R+ 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   LIISRNPDYRQPGCRIFADIDGALEYA-QVCPEVFVIGGATLYEALLPQADFVYLTLIHR  119
            L+ISR+++YR  GC + + +  A+  A ++  E++V GGA +Y   LP+A+ V+L+ +H+
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EFAGDTYFPEID  131
             F GD++FP ++
Sbjct  126  TFEGDAFFPMLN  137

37) folA in NC_010645


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (414),  Expect = 4e-27, Method: Compositional matrix adjust.
 Identities = 64/155 (42%), Positives = 100/155 (65%), Gaps = 4/155 (2%)

Query  6    LIVAYARNRVIGRDNTLPWRLPGDLAHFKRSTLGHPIVMGRNTWESLGRPLPGRKNIVVS  65
            L+ A + NRVIG +  +PW++PG+   F+R T G  +VMGR+T ES+G+PLP R  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RNPDYRAEGAIVVPDLQSALKMAE--ADEVFVIGGAQIYSQALPLATRIIATEIQANVAG  123
            R+++YRA G +VV+ L  A+ +A   ++E++V GGA+IY+ ALP A  ++ +E++    G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DAYFPPLAQTEWRETSRQPQPEENGYHYDFVVYER  158
            DA+FP L +TE    S   +  +    Y   VY R
Sbjct  130  DAFFPMLNETEFELVS--TETIQAVIPYTHSVYAR  162

38) dfrA in NC_017138


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (414),  Expect = 4e-27, Method: Compositional matrix adjust.
 Identities = 63/157 (41%), Positives = 110/157 (71%), Gaps = 4/157 (2%)

Query  4    LIVAMDQNRLIGKENDLPWRLPEDLKYFKRITTSHTIVMGRKTFESIGRPLPNRENVVLT  63
            L+ AM+ NR+IG+  ++PW++P + K F+R+T +  +VMGRKTFESIG+PLPNR+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQKDYQQEGATVIHSVeelealdaekedelFVIGGATLYEQTLDVANRLYITHIEESFEG  123
            RQ +Y+  G  V+ ++ +  AL +E  +EL+V GGA +Y  +L  A+ +++++++++FEG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTHFPAVNLSEWRVISKQQGIKDEKNPYTYYFTVYER  160
            D+ FP +N +E  ++S +    +   PYT   +VY R
Sbjct  130  DAFFPMLNETEFELVSTE--TIQAVIPYTH--SVYAR  162

39) Swoo_1009 in NC_010506


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  114 bits (414),  Expect = 4e-27, Method: Compositional matrix adjust.
 Identities = 58/142 (41%), Positives = 101/142 (72%), Gaps = 1/142 (0%)

Query  1    MKIALIAAMANNRVIGKDNQMPWHLPEDLRHFKAMTLGKPIVMGRKTFDSIGRPLPGRHN  60
            ++I L+AAM+ NRVIG++ ++PW +P + + F+ +T GK +VMGRKTF+SIG+PLP RH 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISRQEGLKIEGVTCVSSFDAAVSAAGDI-EELVVIGGGQLYSATLALADKLYLTEINL  119
            +VISRQ   +  G   VS++  A++ A+++ +EL V GG+++Y+ +L+ A+ ++L+E++ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  DVDGDTHFPSWDDGSWLLLDEE  141
              +GD+ FP  ++    L+  E
Sbjct  126  TFEGDAFFPMLNETEFELVSTE  147

40) Theco_1713 in NC_019897


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 5e-27, Method: Compositional matrix adjust.
 Identities = 73/161 (46%), Positives = 111/161 (69%), Gaps = 7/161 (4%)

Query  3    ITLIAAMARNRVIGQDNGLPWRLPDDLKFFMRSTLGRTVLMGRRTFESLPGGPLKNRLNV  62
            I L+AAM+ NRVIG++  +PW++P++ K+F R T G+ V+MGR+TFES+ G PL NR  +
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESI-GKPLPNRHTL  66

Query  63   VLTRQADYRPDGCEVVHSVEEALSRYGD--GELMVAGGAEVYRWFLPHADRMLLTEVDAE  120
            V++RQA+YR+ GC VV ++ +A++  ++   EL VAGGAE+Y   LPHA+ ++L+EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  VEGDARFPEWNPAEWVLVESEQHPADERHVYSFRFNTYVRK  161
             EGDA FP  N +E  LV +E   A    V ++  + Y R+
Sbjct  127  FEGDAFFPMLNETEFELVSTETIQA----VIPYTHSVYARR  163

41) Bxe_A1020 in NC_007951


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 5e-27, Method: Compositional matrix adjust.
 Identities = 65/161 (41%), Positives = 107/161 (67%), Gaps = 5/161 (3%)

Query  6    LIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIVVT  65
            L+ A + N VIG + ++PW++P +  +F+R T G  ++MGRKT ESIG+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDATRRFQGCDTAATLQEALKLAAQDQAPEAFLIGGAQLYVEGLRQADKLIITEISADFE  125
            R+A  R  GC   +TL +A+ LA+ + + E ++ GGA++Y  +L +A+ ++++E+   FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALAS-ELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  126  GDATFPELDETEWEEVAHETHRADAPNDFDYAFVTYKRKGA  166
            GDA FP L+ETE E V+ ET +A  P    Y+   Y R+ +
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

42) Runsl_2666 in NC_015703


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 60/133 (46%), Positives = 93/133 (70%), Gaps = 1/133 (0%)

Query  5    LIVAAAQNGVIGRDNQLIWHLPDDLKQFKRLTTGHPILMGRKTFESIGKPLPNRTSIVIT  64
            L+ A + N VIG + ++ W +P++ K F+RLT G  ++MGRKTFESIGKPLPNR ++VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RNQHWQFEGVMVVNSVEEAIEAARQTGTDEAFVIGGAEIYRMMLPAVDKIYLTEVKAIFE  124
            R+ + +  G +VV+++ +AI  A + G +E +V GGAEIY + LP  + ++L+EV   FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELG-NELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  125  GDAFFRIPDQNKW  137
            GDAFF + ++   
Sbjct  129  GDAFFPMLNETEF  141

43) M5M_13555 in NC_018868


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 67/158 (43%), Positives = 107/158 (68%), Gaps = 7/158 (4%)

Query  3    EVKLALIVAAAENGTIGRDNQLPWHLPGDLAFFKRCTLGKPIVMGRKTFDSIGRPLPGRP  62
             V++ L+ A + N  IG + ++PW +PG+  +F+R T GK +VMGRKTF+SIG+PLP R 
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRH  64

Query  63   NIVVTRQADWQAEGVTVCNSLEQALAVAGALPEAQSAGEVMVIGGAELYRQALPMAQRLY  122
             +V++RQA+ +A G  V ++L +A+A+A+ L     + E+ V GGAE+Y  ALP A+ ++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASEL-----GNELYVAGGAEIYTLALPHAHGVF  119

Query  123  LTRVHATIEGDAHFPAVEKSDWLLESDERHSAEGSNPY  160
            L+ VH T+EGDA FP ++ ++  L S E  + ++  PY
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVSTE--TIQAVIPY  155

44) folA in NC_014640


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 65/156 (42%), Positives = 103/156 (67%), Gaps = 3/156 (1%)

Query  7    LIVAYSANRVIGRDNALPWKLPGDLAHFKRSTLGHPIIMGRKTWDSLGRPLPGRSNIVIS  66
            L+ A +ANRVIG +  +PWK+PG+   F+R T G  ++MGRKT +S+G+PLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RNPDFSAAGAIVVPSLEAAIQACGDIDAA-FVIGGAQIYAQALPLARRVLATEVRAEVEG  125
            R++++ A+G +VV++L  AI   ++++   +V GGA+IY+ ALP A+ V+ +EV+   EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  126  DAFFPLLPAFQWQETAREAQPAENGYEYDFVTYERQ  161
            DAFFP+L   + +  + E+  A   Y      Y R+
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYTHS--VYARR  163

45) BCAN_A1430 in NC_010103


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 105/149 (71%), Gaps = 5/149 (3%)

Query  6    VSIVVAVSENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A++ N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

46) BCA52141_I2945 in NC_016778


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 105/149 (71%), Gaps = 5/149 (3%)

Query  6    VSIVVAVSENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A++ N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

47) Ccel_1310 in NC_011898


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (412),  Expect = 6e-27, Method: Compositional matrix adjust.
 Identities = 63/157 (41%), Positives = 102/157 (65%), Gaps = 6/157 (3%)

Query  4    MIWAMGRNNALGCKNRMPWYIPADFAYFKKVTMGKPVIMGRKTFESIGKPLPGRKNIVIT  63
            ++ AMG N  +G    +PW IP++   F+++T GK V+MGRKTFESIGKPLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RDTGYDPQGCIVVNSIEKAMEYTEE--KEVFIIGGAEIYKEFLPIADRLYITLIEKEFEA  121
            R++ Y + GC+VV+++  A+  + E  +E+++ GGAEIY   LP A+ ++++ +++ FE+
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  122  DAFFPEIDYSKWKQISCETGIKDEKNPYEYKWLVYER  158
            DAFFP ++ +    +S ET     +    Y   VY R
Sbjct  130  DAFFPMLNETEFELVSTET----IQAVIPYTHSVYAR  162

48) BTH_I1674 in NC_007651


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  113 bits (411),  Expect = 7e-27, Method: Compositional matrix adjust.
 Identities = 65/161 (41%), Positives = 109/161 (68%), Gaps = 5/161 (3%)

Query  58   LIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVT  117
            L+ A + N VIG +  +PWK+P +  +F+R T G  +VMGRKT ESIG+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  118  RDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQDFE  177
            R+A  R  GC   ++L++A+ALA  + + E ++ GGA++Y+ +L HA+ ++++E++Q FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALAS-ELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  178  GDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRKRA  218
            GDA FP  + ++ E VS ++ +A  P    Y+  VY R+ +
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

49) TOL_3595 in NC_020888


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 68/161 (43%), Positives = 103/161 (64%), Gaps = 11/161 (6%)

Query  1    MVAVAQNRVIGRNNALPWYLPEDLKYFKKTTLGKPIIMGRKTFESIGKPLPGRTNIIITR  60
            + A++ NRVIG    +PW +P + K F++ T GK ++MGRKTFESIGKPLP R  ++I+R
Sbjct  11   VAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR  70

Query  61   QPDFTADGIKVVHTVEAARELAESICLVNGQDEAM-IIGGAEIYGLTLPHCDRLYLTEVH  119
            Q+++ A G  VV T      L+++I L +  ++ + + GGAEIY L+LPH + ++L+EVH
Sbjct  71   QANYRATGCVVVST------LSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  120  ADVEGDAFFPEYDKAAWQEVAREDFAADGPNPYDYSFVVYE  160
               EGDAFFP  + +  + V+ E + A  P    Y+  VY 
Sbjct  125  QTFEGDAFFPMLNETEFELVSTETIQAVIP----YTHSVYA  161

50) BAA13334_I01741 in NC_016795


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

51) folA in NC_006932


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

52) BAbS19_I13240 in NC_010742


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

53) BMEA_A1445 in NC_012441


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

54) folA in NC_007618


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

55) BMEI0609 in NC_003317


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

56) folA in NC_017244


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

57) BM590_A1399 in NC_017246


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

58) BMNI_I1353 in NC_017248


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

59) folA in NC_013119


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

60) folA in NC_015857


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

61) folA in NC_017251


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

62) folA in NC_004310


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

63) BSUIS_A1449 in NC_010169


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

64) folA in NC_016797


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  112 bits (408),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 104/149 (70%), Gaps = 5/149 (3%)

Query  6    VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV  65
            + +V A + N VIG+  ++PW+++ + K F+ LT GK V+MGR+T +S+G+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR  125
            I+R+A++RA G  VV++L +A+ALA  ++     +E+ V GG++IY  A+P A+ + L+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  126  VLSVIEGDTYFPEINPQDWQLLSSEDVPA  154
            V   +EGD++FP +N  + +L+S+E + A
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQA  151

65) folA in NC_008570


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  111 bits (405),  Expect = 2e-26, Method: Compositional matrix adjust.
 Identities = 65/152 (43%), Positives = 106/152 (70%), Gaps = 1/152 (0%)

Query  3    ISMIAAMAHDRVIGLDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRNLV  62
            I ++AAM+ +RVIG + ++PW +P++   F+R+T GK V+MGRKTFESIG+PLP R+ LV
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRNPDYRADGVEVIDSVDAALALLAGSDVAELMVIGGGHLYGQLLPRADRLYLTRIDLA  122
            ISR+++YRA G  V+ ++  A+A LA+    EL V GG+++Y   LP+A+ ++L+ ++ +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIA-LASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  VEGDTRFPAFDEGDWSCIERESHQPDEKNPHS  154
             EGD+ FP ++E +   +  E+ Q+     HS
Sbjct  127  FEGDAFFPMLNETEFELVSTETIQAVIPYTHS  158

66) folA in NC_016642


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  111 bits (403),  Expect = 3e-26, Method: Compositional matrix adjust.
 Identities = 61/148 (42%), Positives = 104/148 (71%), Gaps = 9/148 (6%)

Query  3    QISMISAVAENGVIGANNDMPWSVSTDLKFFRKTTTGKPVIMGRRTFESICTTLGKPLPN  62
            +I +++A++ N VIG   ++PW ++ + K+FR+ T GK V+MGR+TFESI    GKPLPN
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESI----GKPLPN  62

Query  63   RKNIVITRDPNYAYDGVEVVSSLGDALTLANDIAENDDVDEIMIVGGGQIYKEAMPKAST  122
            R  +VI+R++NY   G  VVS+L++A++LA++++     +E+ + GG++IY  A+P A  
Sbjct  63   RHTLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHG  117

Query  123  LYITRIHAQPDGDTKFPEIHEDEWELVE  150
            ++++ +H   +GD+ FP ++E E ELV 
Sbjct  118  VFLSEVHQTFEGDAFFPMLNETEFELVS  145

67) AHML_18030 in NC_021290


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  110 bits (402),  Expect = 3e-26, Method: Compositional matrix adjust.
 Identities = 65/152 (43%), Positives = 105/152 (70%), Gaps = 1/152 (0%)

Query  3    ISMIAAMAHDRVIGLDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRNLV  62
            I ++AAM+ +RVIG + ++PW +P++   F+R+T GK V+MGRKTFESIG+PLP R+ LV
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRNPDYRADGVEVIDSVDAALALLAGSDVAELMVIGGGHLYGQLLPRADRLYLTRIDLA  122
            ISR+++YRA G  V+ ++  A+A LA+    EL V GG+++Y   LP+A+ ++L+ ++ +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIA-LASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  VEGDTRFPAFDEGDWSCIEREPHQPDEKNPHS  154
             EGD+ FP ++E +   +  E  Q+     HS
Sbjct  127  FEGDAFFPMLNETEFELVSTETIQAVIPYTHS  158

68) Tgr7_2748 in NC_011901


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  110 bits (401),  Expect = 4e-26, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 100/134 (75%), Gaps = 1/134 (0%)

Query  1    MRLSLIVAVDRNNLIGRDNQLPWHLPADLAFFKRTTMGAPMLMGRKTWESIGRPLPGRTS  60
            +R+ L+ A++ N +IG + ++PW +P++  +F+R T G  ++MGRKT ESIG+PLP R +
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVITRDPDYRAEGARVVHSIEEGIAAAGD-APELFVIGGAKLFVDTLPLADRLYLTRIDH  119
            +VI+R+++YRA G  VV ++ ++IA A++ + EL+V GGA ++  +LP A+ ++L+ +++
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  AFEGDTWFPEIGDA  133
            +FEGD+ FP + ++
Sbjct  126  TFEGDAFFPMLNET  139

69) Noca_2312 in NC_008699


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  110 bits (399),  Expect = 6e-26, Method: Compositional matrix adjust.
 Identities = 67/141 (48%), Positives = 103/141 (74%), Gaps = 0/141 (0%)

Query  1    MTPGGKRVVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPL  60
            M + + R+ LVAA++ N VIG+GP+IPW++PGEQ++F+ LT G ++VMGR T++SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PGRTTIVLTRSPDWSAEGvhvahdlpaalaladTLEGEVMVAGGGQVYAAALPVADEQVL  120
            P R T+V++R ++  A G  V   L+ A+ALA  L  E+ VAGG+++Y+ ALP A+   L
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  121  SEVDLEPQGDAFYPEFDRSEW  141
            SEV+   +GDAF+P ++ +E 
Sbjct  121  SEVHQTFEGDAFFPMLNETEF  141

70) Ssed_0959 in NC_009831


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  109 bits (396),  Expect = 1e-25, Method: Compositional matrix adjust.
 Identities = 58/131 (45%), Positives = 94/131 (72%), Gaps = 1/131 (0%)

Query  13   RVIGKDNQMPWHLPEDLKHFKAMTLGKPIVMGRKTFESIGRPLPGRHNIVISRQESLKIE  72
            RVIG++ ++PW +P + K F+ +T GK +VMGRKTFESIG+PLP RH +VISRQ + +  
Sbjct  18   RVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRAT  77

Query  73   GVTCVTSFEAAKEVAGD-CEELVVIGGGQLYSSLLKEADKLYLTEINLDVEGDTFFPPWD  131
            G   V+++  A  +A++  +EL V GG+++Y+  L +A+ ++L+E++   EGD+FFP  +
Sbjct  78   GCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLN  137

Query  132  DARWELLSKET  142
            ++  EL+S ET
Sbjct  138  ETEFELVSTET  148

71) SCD_n01866 in NC_022357


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  109 bits (396),  Expect = 1e-25, Method: Compositional matrix adjust.
 Identities = 54/128 (43%), Positives = 92/128 (72%), Gaps = 1/128 (0%)

Query  5    RISIIAAMARNRVIGIANTLPWRLPEDLKHFKALTLGHHILMGRKTYESLGRPLPGRTSV  64
            RI ++AAM+ NRVIG +  +PW++P + K F+ LT G  ++MGRKT+ES+G+PLP R ++
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VITRSQDLQVPGCLVANSIAEAVA-ACNNDDEIFFIGGENLYRQALDVADRIYLTEIKAD  123
            VI+R  + +  GC+V +++++A+A A + ++E++  GG ++Y  AL  A+ ++L+E+   
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  124  FSGDAWFP  131
            F GDA FP
Sbjct  127  FEGDAFFP  134

72) Tola_2373 in NC_012691


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  109 bits (398),  Expect = 7e-26, Method: Compositional matrix adjust.
 Identities = 59/143 (42%), Positives = 102/143 (72%), Gaps = 2/143 (1%)

Query  1    MQISLIVAMAQHRVIGRGNQMPWHLPADLRHFKRVTLGKPVIMGRKTFESIGRPLPGRRN  60
            ++I L+ AM+ +RVIG G ++PW +P++ + F+R+T GK V+MGRKTFESIG+PLP R+ 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   LVITRNSDWQADGVESVNSLDAALALVGD-EAEVMIIGGGQLYREALPLAHRLYLTHIDL  119
            LVI+R+++ +A G   V++L  A+AL ++   E+ + GG+++Y  ALP AH ++L++++ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  TVNDADTWFPDYSVCRWQTVAEE  142
            T  ++D+ FP  +    + V+ E
Sbjct  126  TF-EGDAFFPMLNETEFELVSTE  147

73) folA in NC_010170


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  109 bits (397),  Expect = 8e-26, Method: Compositional matrix adjust.
 Identities = 72/166 (44%), Positives = 99/166 (60%), Gaps = 3/166 (1%)

Query  14   LMSAPPRLTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPL  73
            + S + R+ LV A + NRVIG +  +PWK+PG+   F+R T G  ++MGRKT ES+G+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  74   PGRTNVVISRNLRYAAPGATVVPTLQAAVEACGD-APDAYVIGGAQIYAQALPLAARVIA  132
            P R  +VISR+  Y A G  VV+TL  A+   ++ + + YV GGA+IY+ ALP A  V+ 
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  133  TEVHAHVEGDAFFPYLPSFAWREASRQPQPAENGYDYDFVVYERQA  178
            +EVH   EGDAFFP L        S +   A   Y     VY R+ 
Sbjct  121  SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHS--VYARRN  164

74) Mnod_0700 in NC_011894


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (393),  Expect = 2e-25, Method: Compositional matrix adjust.
 Identities = 58/141 (42%), Positives = 101/141 (72%), Gaps = 1/141 (0%)

Query  4    ITLIAAVAKNRVIGRDNDLAWRLRSDLRHFRALTMGKPVVMGRRTWDSIGRPLPGRRVIV  63
            I L+AA++ NRVIG + +++W++ ++ + FR LT GK VVMGR+T +SIG+PLP R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  64   MTRNPGWSAPGVESAADWPAVLA-RTEGADEIMVAGGAEIFALTLPQADRLHLTEVEAAP  122
            ++R++   A G    +  +  +A  +E ++E+ VAGGAEI++L+LP+A+ + L+EV+ + 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  123  EGDTLFPEIPPGAFREVASES  143
            EGD++FP +    F  V++E+
Sbjct  128  EGDAFFPMLNETEFELVSTET  148

75) Shew185_1041 in NC_009665


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (393),  Expect = 2e-25, Method: Compositional matrix adjust.
 Identities = 61/147 (42%), Positives = 100/147 (69%), Gaps = 3/147 (2%)

Query  1    MRIAMIAAMSNNRVIGKENKMPWHLPEDLRHFKAMTLGKPVLMGRKTFESIGRPLPGRHN  60
            +RI ++AAM+ NRVIG+  ++PW +P + + F+ +T GK V+MGRKTFESIG+PLP RH 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISRQTDLVIEGVTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKL  119
            +VISRQ++    G   V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++  
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EVEGDTFFPHWDDGTWK--ETESLSSI  144
              EGD+FFP  ++       TE++ ++
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAV  152

76) Sbal195_1074 in NC_009997


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (393),  Expect = 2e-25, Method: Compositional matrix adjust.
 Identities = 61/147 (42%), Positives = 100/147 (69%), Gaps = 3/147 (2%)

Query  1    MRIAMIAAMSNNRVIGKENKMPWHLPEDLRHFKAMTLGKPVLMGRKTFESIGRPLPGRHN  60
            +RI ++AAM+ NRVIG+  ++PW +P + + F+ +T GK V+MGRKTFESIG+PLP RH 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISRQTDLVIEGVTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKL  119
            +VISRQ++    G   V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++  
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EVEGDTFFPHWDDGTWK--ETESLSSI  144
              EGD+FFP  ++       TE++ ++
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAV  152

77) Sbal678_1101 in NC_016901


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (393),  Expect = 2e-25, Method: Compositional matrix adjust.
 Identities = 61/147 (42%), Positives = 100/147 (69%), Gaps = 3/147 (2%)

Query  1    MRIAMIAAMSNNRVIGKENKMPWHLPEDLRHFKAMTLGKPVLMGRKTFESIGRPLPGRHN  60
            +RI ++AAM+ NRVIG+  ++PW +P + + F+ +T GK V+MGRKTFESIG+PLP RH 
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISRQTDLVIEGVTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKL  119
            +VISRQ++    G   V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++  
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EVEGDTFFPHWDDGTWK--ETESLSSI  144
              EGD+FFP  ++       TE++ ++
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAV  152

78) NH44784_029401 in NC_021285


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 61/127 (49%), Positives = 90/127 (71%), Gaps = 1/127 (0%)

Query  7    LIVAYSTNRAIGRDNALPWKLPGDLAHFKRSTLGHPIIMGRKTWDSLGRPLPGRANIVVS  66
            L+ A ++NR IG +  +PWK+PG+   F+R T G  ++MGRKT +S+G+PLP R  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RNPAFEAAGATVVPTLEAAIAACGD-SAEAFVIGGAQIYTQALALASRVLATEVHAEVEG  125
            R++ + A+G  VV+TL  AIA  ++ + E +V GGA+IYT AL+ A  V+ +EVH   EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  126  DAFFPLL  132
            DAFFP+L
Sbjct  130  DAFFPML  136

79) folA in NC_011527


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 97/139 (70%), Gaps = 3/139 (2%)

Query  3    ITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIV  62
            I L+AAM+ NR+IG   ++PW +P++   F+ +T GK +VMGR+TF+SIGKPLP+R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ITQQKNLIIEGCDIFYSLDDALSALTKE--PEVIIIGGARIFKEALPKADKMILTIINHS  120
            I++Q N    GC +  +L +A+ AL+ E   E+ + GGA I+  ALP A+ ++L+ ++++
Sbjct  68   ISRQANYRATGCVVVSTLSHAI-ALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  FEGDVYFPEWNDKEWKITS  139
            FEGD +FP  N+ E  + S
Sbjct  127  FEGDAFFPMLNETEFELVS  145

80) folA in NC_011528


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 97/139 (70%), Gaps = 3/139 (2%)

Query  3    ITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIV  62
            I L+AAM+ NR+IG   ++PW +P++   F+ +T GK +VMGR+TF+SIGKPLP+R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ITQQKNLIIEGCDIFYSLDDALSALTKE--PEVIIIGGARIFKEALPKADKMILTIINHS  120
            I++Q N    GC +  +L +A+ AL+ E   E+ + GGA I+  ALP A+ ++L+ ++++
Sbjct  68   ISRQANYRATGCVVVSTLSHAI-ALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  FEGDVYFPEWNDKEWKITS  139
            FEGD +FP  N+ E  + S
Sbjct  127  FEGDAFFPMLNETEFELVS  145

81) folA in NC_009727


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 97/139 (70%), Gaps = 3/139 (2%)

Query  3    ITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIV  62
            I L+AAM+ NR+IG   ++PW +P++   F+ +T GK +VMGR+TF+SIGKPLP+R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ITQQKNLIIEGCDIFYSLDDALSALTKE--PEVIIIGGARIFKEALPKADKMILTIINHS  120
            I++Q N    GC +  +L +A+ AL+ E   E+ + GGA I+  ALP A+ ++L+ ++++
Sbjct  68   ISRQANYRATGCVVVSTLSHAI-ALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  FEGDVYFPEWNDKEWKITS  139
            FEGD +FP  N+ E  + S
Sbjct  127  FEGDAFFPMLNETEFELVS  145

82) folA in NC_010117


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 97/139 (70%), Gaps = 3/139 (2%)

Query  3    ITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIV  62
            I L+AAM+ NR+IG   ++PW +P++   F+ +T GK +VMGR+TF+SIGKPLP+R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ITQQKNLIIEGCDIFYSLDDALSALTKE--PEVIIIGGARIFKEALPKADKMILTIINHS  120
            I++Q N    GC +  +L +A+ AL+ E   E+ + GGA I+  ALP A+ ++L+ ++++
Sbjct  68   ISRQANYRATGCVVVSTLSHAI-ALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  FEGDVYFPEWNDKEWKITS  139
            FEGD +FP  N+ E  + S
Sbjct  127  FEGDAFFPMLNETEFELVS  145

83) folA in NC_002971


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 97/139 (70%), Gaps = 3/139 (2%)

Query  3    ITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIV  62
            I L+AAM+ NR+IG   ++PW +P++   F+ +T GK +VMGR+TF+SIGKPLP+R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ITQQKNLIIEGCDIFYSLDDALSALTKE--PEVIIIGGARIFKEALPKADKMILTIINHS  120
            I++Q N    GC +  +L +A+ AL+ E   E+ + GGA I+  ALP A+ ++L+ ++++
Sbjct  68   ISRQANYRATGCVVVSTLSHAI-ALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  FEGDVYFPEWNDKEWKITS  139
            FEGD +FP  N+ E  + S
Sbjct  127  FEGDAFFPMLNETEFELVS  145

84) folA in NC_003062


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  108 bits (391),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 61/142 (43%), Positives = 103/142 (73%), Gaps = 6/142 (4%)

Query  5    RVTIIVAVSENGVIGRDLDMPWKLSTDLKRFKAMTMGKPLIMGRKTFLSVGERPLPGRPH  64
            R+ ++ A++ N VIG + ++PWK++ + K F+ +T GK ++MGRKTF S+G +PLP R  
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRHT  65

Query  65   IIVSRNADYRPEGVDVVSSLDEAVKLAKTKAVELGVDEVFVAGGGEIYRQAMPFADQLSV  124
            +++SR+A+YR+ G  VVS+L +A+ LA     ELG +E++VAGG+EIY  A+P A+ + +
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALAS----ELG-NELYVAGGAEIYTLALPHAHGVFL  120

Query  125  THVAVKLDGDTFFPEIDPAVFE  146
            ++V   ++GD+FFP ++ + FE
Sbjct  121  SEVHQTFEGDAFFPMLNETEFE  142

85) folA in NC_017067


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  107 bits (390),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 69/167 (42%), Positives = 112/167 (68%), Gaps = 10/167 (5%)

Query  1    MRKALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMN  60
            +R  L+ AM+ NRVIG   ++PW +PG+ + F++ T GK ++MGRKT +SIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   VVISRNPEWQAPAGTVAAASLNEALVKAEAQAELEGGDEVMIIGGGQIYAEALPMVDRIY  120
            +VISR+++ +A +G V  ++L++A+  A   +EL  G+E+ + GG++IY+ ALP  + ++
Sbjct  66   LVISRQANYRA-TGCVVVSTLSHAIALA---SEL--GNELYVAGGAEIYTLALPHAHGVF  119

Query  121  ITQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR  167
            +++VH   +GDAFFP +N  E E ++ E + A    PY  S  VY R
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVSTETIQAV--IPYTHS--VYAR  162

86) Kfla_5968 in NC_013729


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  107 bits (390),  Expect = 3e-25, Method: Compositional matrix adjust.
 Identities = 63/155 (41%), Positives = 103/155 (67%), Gaps = 5/155 (3%)

Query  3    VVLIAAVGRNGVIGRDNELPWRIREDLQHFKALTLGHTLVMGRKTYDSIGRPLPGRRTVV  62
            + L+AA+G N VIG + ++PW+I  + + F+ LT G  +VMGRKT++SIG+PLP R+T+V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   VTRQPDWSAPGVEVAHSLAAALELAD--GKDVYVAGGGEIYRQALPSADRLELTEVDQSP  120
            ++RQ++  A G  V  +L+ A+ LA   G+++YVAGG+EIY  ALP A+ + L+EV+Q+ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  AGDVTFPAVDRSAWTETAREPHDG---FAFVTYVR  152
             GD  FP ++ +     + E  ++   ++   Y R
Sbjct  128  EGDAFFPMLNETEFELVSTETIQAVIPYTHSVYAR  162

87) Shal_0910 in NC_010334


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  107 bits (388),  Expect = 4e-25, Method: Compositional matrix adjust.
 Identities = 56/134 (42%), Positives = 95/134 (71%), Gaps = 1/134 (0%)

Query  13   RVIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIVISRQTDLSID  72
            RVIG++ ++PW +P + + F+ +T GK VVMGRKT+ESIG+PLP RH +VISRQ++    
Sbjct  18   RVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRAT  77

Query  73   GVTIVSSFAEAKIAAGE-CEELVVMGGGQLYEMLLPQADILYLTEIALTVDGDTYFPEWD  131
            G  +VS++++A   A+E  +EL V GG+++Y + LP+A+ ++L+E+  T +GD++FP  +
Sbjct  78   GCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLN  137

Query  132  DGSWQEVSRNVAED  145
            +   + VS +  + 
Sbjct  138  ETEFELVSTETIQA  151

88) Shew_0874 in NC_009092


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  107 bits (389),  Expect = 4e-25, Method: Compositional matrix adjust.
 Identities = 55/131 (42%), Positives = 91/131 (70%), Gaps = 1/131 (0%)

Query  13   RVIGKDNQMPWHLPEDLRHFKQMTLGKPVVMGRKTFESIGRPLPGRHNLVVSRQEDLVIE  72
            RVIG++ ++PW +P + + F+++T GK VVMGRKTFESIG+PLP RH LV+SRQ +    
Sbjct  18   RVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRAT  77

Query  73   GVTCVTSFEQAKELVQG-CDELVVIGGGQLYAELLPQADRLYLTEINLDVEGDTHFPDWD  131
            G   V+++ +A  L     +EL V GG+++Y+  LP+A+ ++L+E++   EGD+ FP  +
Sbjct  78   GCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLN  137

Query  132  DGSWQLLDSES  142
            +   +L+ +E+
Sbjct  138  ETEFELVSTET  148

89) UMN179_01397 in NC_015460


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (387),  Expect = 5e-25, Method: Compositional matrix adjust.
 Identities = 61/136 (45%), Positives = 100/136 (74%), Gaps = 6/136 (4%)

Query  4    LIVAMSKNRVIGRDNQMPWHLPADLAWFKKNTLGKPVIMGRKTFQSIGRALPNRKNIVLS  63
            L+ AM+ NRVIG + ++PW +P++   F++ T GK V+MGRKTF+SIG++LPNR  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQG-FQADGIEVVSDLSQALALIKG-ENEVMVIGGGHLFAETLPIADRLYLTEIDAELQG  121
            RQ+ ++A G  VVS LS+A+AL     NE+ V GG+++++ +LP A+ ++L+E++  ++G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  122  DTFFPEIDPMVWKTNF  137
            D+FF    PM+  T+F
Sbjct  130  DAFF----PMLNETEF  141

90) Maqu_2431 in NC_008740


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (387),  Expect = 5e-25, Method: Compositional matrix adjust.
 Identities = 68/167 (41%), Positives = 110/167 (66%), Gaps = 10/167 (5%)

Query  1    MRKALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMN  60
            +R  L+ AM+ NRVIG   ++PW +PG+ + F++ T GK ++MGRKT +SIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   VVISRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGDEVMIIGGGQIYAEALPMVDRIY  120
            +VISR+++ +A +G V  ++L++A+  A      E G+E+ + GG++IY+ ALP  + ++
Sbjct  66   LVISRQANYRA-TGCVVVSTLSHAIALAS-----ELGNELYVAGGAEIYTLALPHAHGVF  119

Query  121  ITQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR  167
            +++VH   +GDAFFP +N  E E ++ E + A    PY  S  VY R
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVSTETIQAV--IPYTHS--VYAR  162

91) Sama_2824 in NC_008700


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (385),  Expect = 8e-25, Method: Compositional matrix adjust.
 Identities = 57/128 (45%), Positives = 92/128 (72%), Gaps = 1/128 (0%)

Query  14   VIGKDNQMPWHLPEDLKHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQSDYSHEG  73
            VIG++ ++PW +P + K F+ +T GK VVMGRKTFESIG+PLP RH +VISRQ++Y   G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   ISLVSSFEEAVALAGD-CEELVVIGGGQLYQTLISQADKLYLTEIALEVEGDTHFPAWDD  132
              +VS++ +A+ALA++  +EL V GG+++Y   +++A+ ++L+E+    EGD+ FP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  GSWETVES  140
               E V +
Sbjct  139  TEFELVST  146

92) M446_1090 in NC_010511


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (385),  Expect = 8e-25, Method: Compositional matrix adjust.
 Identities = 60/142 (43%), Positives = 98/142 (70%), Gaps = 1/142 (0%)

Query  3    RVTLIAAVARNGVIGRDNDLAWRLRGDLRRFRALTMGKPVVMGRRTWDSIGRPLPGRRVI  62
            R+ L+AA++ N VIG + +++W++ G+ + FR LT GK VVMGR+T +SIG+PLP R+ +
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  63   VMTRDPGWSAPGVETAAGWDAVLALVGE-AEEVMVAGGAQIYALTLPLADRIELTEVAAA  121
            V++R++   A G    +     +AL +E ++E+ VAGGA+IY+L+LP A+ + L+EV  +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  122  PEGDARFPEIPAGRFREVASEA  143
             EGDA FP +    F  V++E+
Sbjct  127  FEGDAFFPMLNETEFELVSTET  148

93) Sden_2922 in NC_007954


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (385),  Expect = 8e-25, Method: Compositional matrix adjust.
 Identities = 59/147 (41%), Positives = 99/147 (68%), Gaps = 3/147 (2%)

Query  14   VIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVITRQLDYAIEG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VI+RQ +Y   G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VSCVSSFDEAKKIAGD-CDELIVMGGGQLYAEILPFAEVMYLTLIKLDVEGDTFFPAWNE  132
               VS++ +A  +A++  +EL V GG+++Y+  LP A+ ++L+ +    EGD+FFP  NE
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  QEWQVSQTESVTNHDGLEYSFNTLVKK  159
             E ++  TE++  +  + Y+ +   ++
Sbjct  139  TEFELVSTETI--QAVIPYTHSVYARR  163

94) Alvin_2149 in NC_013851


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  106 bits (384),  Expect = 9e-25, Method: Compositional matrix adjust.
 Identities = 63/138 (46%), Positives = 90/138 (66%), Gaps = 2/138 (1%)

Query  15   IALVAAMDEARVIGRDNALPWRLPADLAHFKALTLDKPILMGRKTWESLPGLLPRRRHLV  74
            I LVAAM+  RVIG +  +PW++P++   F+ LT +K ++MGRKT ES+   LP R+ LV
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  75   ISRDPDYRAEGCEVFGSLETAIAAVDE--PELMIVGGASIYAQSLPLADRLHLTIVQTRV  132
            ISR+++YRA GC V ++L  AIA   E   EL + GGA IY+ +LP A+ + L+ V+   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  133  TGDAWFPAWNPVEWNAVA  150
             GDA FP  N  E + V+
Sbjct  128  EGDAFFPMLNETEFELVS  145

95) Emtol_1434 in NC_018748


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (383),  Expect = 1e-24, Method: Compositional matrix adjust.
 Identities = 58/135 (43%), Positives = 95/135 (71%), Gaps = 3/135 (2%)

Query  4    IIVATAENGVIGKDNQMLWKLSTDFKYFKNLTTGHSVIMGRKTFESIGRPLPNRTNIVIS  63
            ++ A + N VIG++ ++ WK++ + K F+ LT G  V+MGRKTFESIG+PLPNR  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQQDFVLPEGVLKASSLENAIELAKTHVGSEEIFIIGGGNVYEQALKITDKIYLTEVDAN  123
            RQ ++  + G +  S+L +AI LA     ++E+++ GG+++Y  AL  ++ ++L+EV+  
Sbjct  70   RQANYR-ATGCVVVSTLSHAIALASEL--GNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  124  IEGDAFFPTLDMSEW  138
            +EGDAFFP L+ +E 
Sbjct  127  FEGDAFFPMLNETEF  141

96) Lbys_2007 in NC_014655


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (383),  Expect = 1e-24, Method: Compositional matrix adjust.
 Identities = 54/128 (43%), Positives = 91/128 (72%), Gaps = 2/128 (1%)

Query  5    LLVAVAENGVIGKDNQLLWKLRDDLQLFKKRTLGHPIIMGRKTYESIGKPLPGRTNIVIS  64
            L+ A++ N VIG++ ++ WK+ ++ ++F++ T G  ++MGRKT+ESIGKPLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RNAGLKLEGCTVTSSLEEALEVAQNLHPEQEIFVIGGGKIYELATPIATKLYLTKVNVVL  124
            R+A  +  GC V S+L +A+ +A +L   +E++V GG+ IY LA P A  ++L+ V+  +
Sbjct  70   RQANYRATGCVVVSTLSHAIALASEL--GNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  125  EGDTYFDL  132
            EGD++F +
Sbjct  128  EGDAFFPM  135

97) HP15_587 in NC_017506


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (382),  Expect = 1e-24, Method: Compositional matrix adjust.
 Identities = 71/169 (43%), Positives = 109/169 (65%), Gaps = 10/169 (5%)

Query  1    MRKALIVAMSRNRVIGRNNNLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMN  60
            +R  L+ AM+ NRVIG   N+PW +PG+ + F++ T GK ++MGRKT +SIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   VVISRNEAWEAPTGTVAAKSLPEALVKAEAQAELEGGDEVMIIGGGQIYAEALPMVDRMY  120
            +VISR+    A TG V   +L++A+  A   +EL  G+E+ + GG++IY+ ALP  + ++
Sbjct  66   LVISRQANYRA-TGCVVVSTLSHAIALA---SEL--GNELYVAGGAEIYTLALPHAHGVF  119

Query  121  ITQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQRQA  169
            +++VH   +GDAFFP +N  E E ++ E + A    PY  S  VY R+ 
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVSTETIQAV--IPYTHS--VYARRN  164

98) Hneap_0899 in NC_013422


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (382),  Expect = 1e-24, Method: Compositional matrix adjust.
 Identities = 65/162 (41%), Positives = 107/162 (67%), Gaps = 6/162 (3%)

Query  1    MKIGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKN  60
            ++I LVAA+  N+VIG    +PW +P++ + F+++T GK ++MGRKT++SIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISRNPDFHADGVTVVDSLDMALE-AADQAPEVMVIGGANIYYQFLPRADRLYFTLVHT  119
            +VISR+++++A G  VV +L  A+  A++ + E+ V GGA+IY   LP+A+ ++++ VH 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  TIDDGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR  161
            T+ +GDAFFP  N  +  LV  E      +  +PY+     R
Sbjct  126  TF-EGDAFFPMLNETEFELVSTET----IQAVIPYTHSVYAR  162

99) dfrA in NC_017025


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (380),  Expect = 2e-24, Method: Compositional matrix adjust.
 Identities = 62/136 (46%), Positives = 96/136 (71%), Gaps = 2/136 (1%)

Query  4    IIAAAAENNALGKDNQLVWHLPDDFKRFKSLTSGHYIIMGRKTFESFPKPLPNRTHVIIT  63
            ++AA + N  +G++ ++ W +P++ K F+ LT G  ++MGRKTFES+ KPLPNR  ++I+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQANYEVPEGCVVVSSLQEAIAFCPK-EEEVFVIGGGQIYQQAIDLVDKIDLTRVHTTVE  122
            RQANY  + GCVVVS+L +AIA+ +   +E++V GG++IY  A+   + + L+ VH T E
Sbjct  70   RQANYR-ATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  123  ADAFFPEINTQKWELV  138
            +DAFFP +N    ELV
Sbjct  129  GDAFFPMLNETEFELV  144

100) folA in NC_014803


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (381),  Expect = 2e-24, Method: Compositional matrix adjust.
 Identities = 52/125 (42%), Positives = 94/125 (76%), Gaps = 1/125 (0%)

Query  1    MIAAMANNRVIGLDNKMPWHLPGDLQHFKKVTSGKPVIMGRKTFESIGRPLPGRRNIIIT  60
            ++AAM+ NRVIG + ++PW +PG+ + F+++T GK V+MGRKTFESIG+PLP R+ ++I+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  61   RNKDYHASGIETVTTPEAALELVNDVAEVM-IIGGGNIYQQFLAQAQRLYLTFIDLDVEG  119
            R+ +Y+A+G   V+T   A+ L +++++ + + GG++IY   L++A+ ++L+ ++   EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  120  DTQFP  124
            D+ FP
Sbjct  130  DAFFP  134

101) folA in NC_004347


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  105 bits (380),  Expect = 2e-24, Method: Compositional matrix adjust.
 Identities = 54/130 (42%), Positives = 91/130 (70%), Gaps = 1/130 (0%)

Query  14   VIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLQIEG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+ +  G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFEAAKRVAGD-CEELVVIGGGQLYKQLLPQADRLYLTQINLDVDGDTFFPAWED  132
               V+++  A  +A++  +EL V GG+++Y   LP+A+ ++L++++   +GD+FFP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  NEWQKTETQP  142
             E +   T+ 
Sbjct  139  TEFELVSTET  148

102) Mpop_2781 in NC_010725


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  104 bits (378),  Expect = 3e-24, Method: Compositional matrix adjust.
 Identities = 60/135 (45%), Positives = 96/135 (72%), Gaps = 2/135 (1%)

Query  5    RVSLIAAVARNGVIGRDNDLVWRISSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            R+ L+AA++ N VIG + ++ W+I+++ K F+ LT GK ++MGRKT +SIG+PLP R++L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VLTRDRALTLSDVTIVHDWDEALAAAG--GDELMVVGGAEIYRLALPHADRLHLTEVDAA  122
            V++R+     ++  +V    +A+A A+  G+EL V GGAEIY LALPHA+ + L+EV+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  PEGDVHFPPFDRTAY  137
             EGD  FP ++ T +
Sbjct  127  FEGDAFFPMLNETEF  141

103) folA in NC_021287


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  104 bits (377),  Expect = 3e-24, Method: Compositional matrix adjust.
 Identities = 60/147 (41%), Positives = 101/147 (69%), Gaps = 2/147 (1%)

Query  6    LIVARARNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVS  65
            L+ A + N VIG + ++PW++P +  +F+R T G  +VMGRKT ESIG+PLP R+ +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDATRRYEGCDVVTSLDAALALEP--ANEAFLIGGAQLYRDAIARADKMIVTEIDADFDG  123
            R+A  R  GC VV++L  A+AL +  +NE ++ GGA++Y  A+++A+ ++++E++  F+G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTHFPAPDPAHWREVSREPHRAAAPNT  150
            D+ FP  + ++   VS E  +A  P T
Sbjct  130  DAFFPMLNETEFELVSTETIQAVIPYT  156

104) Aave_1448 in NC_008752


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  104 bits (376),  Expect = 4e-24, Method: Compositional matrix adjust.
 Identities = 67/161 (42%), Positives = 101/161 (63%), Gaps = 7/161 (4%)

Query  5    LIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRTNI  64
            L+ A +AN  IG    +PW +P +   F++LT G  VVMGRKT +S+    +PLP R  +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  65   VVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIHRD  124
            V++RQA  +A G +  S+L +A+ LA   G+ + V GGA+IY+ ALP A+GV ++E+H+ 
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  125  FEADAFAPVLGPEWEETARTPVQTSAGSAALPFSFVSYRRR  165
            FE+DAF P+L    +ET    V T +  A +P++   Y RR
Sbjct  127  FEGDAFFPML----NETEFELVSTETIQAVIPYTHSVYARR  163

105) O3Y_02040 in NC_016944


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

106) folA in NC_012578


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

107) VCD_001166 in NC_012668


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

108) folA in NC_016445


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

109) VC0440 in NC_002505


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

110) folA in NC_012582


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

111) folA in NC_009457


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 96/127 (76%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALAKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+A A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

112) FCOL_04070 in NC_016510


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (375),  Expect = 5e-24, Method: Compositional matrix adjust.
 Identities = 58/138 (43%), Positives = 93/138 (68%), Gaps = 2/138 (1%)

Query  4    KIILIAAAGQNNELGKNNNLLWHLPNDFKHFKTLTSGHCIIMGRKTFESFSKPLPNRTHI  63
            +I L+AA G N  +G+  N+ W +P + K F+ LT G  ++MGRKTFES++KPLPNR  +
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  64   IITRKKEYAVPEECIVVHYLEEALQ-ACPVDQEVYVIGGGEIYRQFIDLADQIELTRVHG  122
            +I+R+ +Y  +  C+VV  L +A+  A  +++E+YV GG+EIY   +  A+ + L+ VH 
Sbjct  67   VISRQANYR-ATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  123  CFEADTFFPDIDQDKWEL  140
             FE+D+FFP +++   EL
Sbjct  126  TFEGDAFFPMLNETEFEL  143

113) VCLMA_A0398 in NC_017270


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (372),  Expect = 9e-24, Method: Compositional matrix adjust.
 Identities = 56/127 (45%), Positives = 95/127 (75%), Gaps = 1/127 (0%)

Query  3    ISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLQIEGVDVVTSIEAALVKAGEV-DEVMIIGGGSLYAACLPMAHKLYITEIHAKL  121
            ISR+A+ +  G  VV+++  A+  A+E+ +E+ + GG+ +Y+  LP AH ++++E+H  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  EGDTQFP  128
            EGD+ FP
Sbjct  128  EGDAFFP  134

114) Acav_1487 in NC_015138


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (372),  Expect = 9e-24, Method: Compositional matrix adjust.
 Identities = 67/161 (42%), Positives = 101/161 (63%), Gaps = 7/161 (4%)

Query  5    LIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRTNI  64
            L+ A +AN  IG    +PW +P +   F++LT G  VVMGRKT +S+    +PLP R  +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  65   VVTRQAGWHADGALPASSLEQALELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIHRD  124
            V++RQA  +A G +  S+L +A+ LA   G+ + V GGA+IY+ ALP A+GV ++E+H+ 
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  125  FEADAFAPVLGPEWQETARTPVQTSAGSAALPFSFVSYRRR  165
            FE+DAF P+L    +ET    V T +  A +P++   Y RR
Sbjct  127  FEGDAFFPML----NETEFELVSTETIQAVIPYTHSVYARR  163

115) dfrA in NC_009613


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  103 bits (372),  Expect = 9e-24, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 95/139 (69%), Gaps = 2/139 (1%)

Query  4    IIAAAGKNNELGKDNQIIWHLPDDFKRFKAITSGHHIIMGRKTFESFPKPLPNRTHIVIT  63
            ++AA G N  +G++ +I W +P++ K F+ +T G  ++MGRKTFES+ KPLPNR  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RNKNYSLPEDCFVVDSIEKAIDICPK-NKTIFIIGGGEIYKQSINIANCIELTRVHGDFD  122
            R+ NY  + +C VV ++  AI + +   + +++ GG+EIY  ++  A+ + L+ VH  F+
Sbjct  70   RQANYR-ATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  123  ADAFFPTIDLTKWELVSSQ  141
            +DAFFP ++ T  ELVS++
Sbjct  129  GDAFFPMLNETEFELVSTE  147

116) Aeqsu_0718 in NC_018013


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (371),  Expect = 1e-23, Method: Compositional matrix adjust.
 Identities = 55/137 (41%), Positives = 96/137 (71%), Gaps = 2/137 (1%)

Query  4    MIAAAGENNELGKDNGLVWHLPDDFKRFKQLTTGHNIIMGRRTFDSFDKLLRNRKHIVIT  63
            ++AA G N  +G++  + W +P++ K F++LT G  ++MGR+TF+S++K L NR  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RNKEYKKEGAVVVHSMEEALKLCKD-DAEPFIIGGGEIYTTGLPFADKIELTRVHGTFKD  122
            R+ +Y+  G VVV ++ +A+ L  + + E ++ GG+EIYT +LP A+ + L+ VH TF +
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF-E  128

Query  123  ADTFFPEFSTDEWQLVS  139
            +D+FFP ++  E +LVS
Sbjct  129  GDAFFPMLNETEFELVS  145

117) Mlg_0423 in NC_008340


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (369),  Expect = 1e-23, Method: Compositional matrix adjust.
 Identities = 57/140 (41%), Positives = 99/140 (71%), Gaps = 1/140 (0%)

Query  7    ITLIAALADNGVIGRDNDLPWRIPADLKRFKARTQGRPLIMGRRNYESIGRPLPGRHNIV  66
            I L+AA++ N VIG + ++PW+IP++ K F+  T+G+ ++MGR+ +ESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  67   LTRRRDWQAEGCTVVHDPEAALAAAGDveevm-viggeeiYRLFLPRADRLELTRVHTEV  125
            ++R+ + +A GC VV     A+A A+++ + + V GG EIY L LP+A+ + L+ VH   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  126  PGDTFFPDIDPADWQVVAEQ  145
             GD+FFP ++ ++ ++V+ +
Sbjct  128  EGDAFFPMLNETEFELVSTE  147

118) folA in NC_010995


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (371),  Expect = 1e-23, Method: Compositional matrix adjust.
 Identities = 68/167 (41%), Positives = 103/167 (62%), Gaps = 10/167 (5%)

Query  1    MQVALIVAAAANGIIGRDNQLPWHLPQDLKYFKATTMGKPVIMGRKTYESIGKPLPGRPN  60
            +++ L+ A +AN +IG + ++PW +P + K F+  T GK V+MGRKT+ESIGKPLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVVTRNPLWRATEGVKlagsleealahaeelIADSPDLLPEAMVIGGAEIYRSALPLASR  120
            +V++R++  RAT  V         ++   + IA +++L  E  V GGAEIY  ALP A  
Sbjct  66   LVISRQANYRATGCV--------VVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHG  117

Query  121  VYLTRVDVQVDGDAFFPVLDEGEWQLASSRDGEKNAALPHRFLVYDR  167
            V+L+ V+   +GDAFFP+L+E E +L S+   +   +  H   VY R
Sbjct  118  VFLSEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHS--VYAR  162

119) Clole_0608 in NC_015275


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (370),  Expect = 1e-23, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 94/139 (68%), Gaps = 1/139 (0%)

Query  2    ICLIAAVSKNNQIGLHNQMPWHIPEDLAYFREVTSGHTVIMGRKTFESIGKPLPHRTNMV  61
            I L+AA++ N  IG   ++PW IP +   FR +T G  V+MGRKTFESIGKPLP+R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  62   LTTNPNFSAEGVVVLHSLNEALELCKTTTEAVFVIGGGEIYKAFLPFAEYLYITLIDEVV  121
            ++ ++N+ A G VV+ +L++A+ L     + ++V GG+EIY   LP A+ ++++ +++  
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  EGDTCFPDY-QKDFQLIKS  139
            EGD+ FP   + +F+L+ +
Sbjct  128  EGDAFFPMLNETEFELVST  146

120) Spea_0857 in NC_009901


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (368),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 55/134 (42%), Positives = 93/134 (70%), Gaps = 1/134 (0%)

Query  13   RVIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIVISRQDSLVID  72
            RVIG++ ++PW +P + + F+ +T GK VVMGRKT+ESIG+PLP RH +VISRQ +    
Sbjct  18   RVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRAT  77

Query  73   GVTRVSSFEEAKIAAGD-CDELVVMGGGQLYEMLLSQADILYLTEINLTVEGDTYFPEWD  131
            G   VS++ +A   A++  +EL V GG+++Y + L++A+ ++L+E++ T EGD++FP  +
Sbjct  78   GCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLN  137

Query  132  NGSWQEVSRDVAKN  145
            +   + VS +  + 
Sbjct  138  ETEFELVSTETIQA  151

121) H045_19415 in NC_020209


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  102 bits (368),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 59/147 (41%), Positives = 98/147 (67%), Gaps = 5/147 (3%)

Query  4    TLPLSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRL  63
            ++ + L+AA+G NRVIG + ++PW +PG+ K F+  T GK ++MGRKT +S+G+PLP R 
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRH  64

Query  64   NLVVSRQTDLALEGAQVFPSLEAAVQRAEEWALEQGVDELMLIGGAQLYAQGLEQADRLY  123
             LV+SRQ++    G  V ++L  A+  A E +     +EL + GGA++Y+ +L +A+ ++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVF  119

Query  124  LTRVALSPEGDAWFPEFDRSQWTLVSN  150
            L+ V  + EGDA FP ++ ++  LVS 
Sbjct  120  LSEVHQTFEGDAFFPMLNETEFELVST  146

122) G432_09820 in NC_020561


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  101 bits (367),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 61/137 (45%), Positives = 96/137 (71%), Gaps = 3/137 (2%)

Query  1    MSRPRITFYV--ARADNGVIGRGGRLPWRLPEDLKRFKAMTMGKPMVMGRKTFESFPKPL  58
            M+   + +Y+  A + N VIG G  +PW++P + K F+ +T GK +VMGRKTFES+ KPL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  59   PGRRHIVLTRDPAWAADGAEVAHSVDQAIALAGDV-EEVAVIGGAEIYALFMPQADRIEL  117
            P R+ +V++R++   A G  V  ++ +AIALA+++ +E+ V GGAEIY+L +P+A+ + L
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  118  TEVHRTVEGDTKMPPLG  134
            +EVH+T EGD+  P L 
Sbjct  121  SEVHQTFEGDAFFPMLN  137

123) PPE_02527 in NC_014483


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  101 bits (367),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 58/137 (43%), Positives = 98/137 (72%), Gaps = 3/137 (2%)

Query  5    MIWAMAQNGVIGRDNKLPWRLPRDMAFFKEQTINKTVLMGRKTWESFGGKSLPNRRNVVL  64
            ++ AM+ N VIG + ++PW++P +  +F+  T  K V+MGRKT ES+ GK+LPNR+ +V+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESI-GKPLPNRHTLVI  68

Query  65   TRDLRYQAEGAEVIHSLEEGLQLAKQ--EELMVIGGAEIYSLFWPHADRLIVTRIEETFE  122
            +R+  Y+A G  V+ +L +++ LA +  +EL V GGAEIY+L  PHA+ ++++ +++TFE
Sbjct  69   SRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  123  GDTTFPDLDWNGWNIVS  139
            GD+ FP L+    ++VS
Sbjct  129  GDAFFPMLNETEFELVS  145

124) PB2503_08189 in NC_014414


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  101 bits (367),  Expect = 2e-23, Method: Compositional matrix adjust.
 Identities = 57/138 (42%), Positives = 97/138 (71%), Gaps = 1/138 (0%)

Query  2    SPRISLVVAVADNGVIGKDGTLPWRMRDDLKWFKSVTTGKPIVMGRTTWESLGDPLPQRR  61
            S RI LV A++ N VIG++  +PW++ ++ K F+ +T GK +VMGR T ES+G PLP+R+
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRH  64

Query  62   NIVVSRQLDNAPEGSEVFAELDEALTAAAGSGADEICVIGGAQLYTAAMARADRLYVTRV  121
             +V+SRQ +  + G  V + L +A++ A+  G +E+ V GGA++YT A+++A+ ++++ V
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELG-NELYVAGGAEIYTLALPHAHGVFLSEV  123

Query  122  HGTPEGDTLFTLPDETGW  139
            H T EGD++F + +ET  
Sbjct  124  HQTFEGDAFFPMLNETEF  141

125) folA in NC_007481


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (363),  Expect = 4e-23, Method: Compositional matrix adjust.
 Identities = 52/121 (43%), Positives = 88/121 (73%), Gaps = 1/121 (0%)

Query  1    MANNRVIGLNNTMPWHLPGDLQHFKKVTTGKPVIMGRKTFESIGRPLPGRRNIIITRNSQ  60
            M+ NRVIG    +PW +PG+ + F+++T GK V+MGRKTFESIG+PLP R+ ++I+R+++
Sbjct  14   MGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQAN  73

Query  61   YQATGIEIVTTPEAALNLVTDV-EEVMIIGGGNIYQQFLESAQRLYLTFIDLDVEGDTQF  119
            Y+ATG  +V+T   A+ L +++ +E+ + GG++IY   L  A+ ++L+ ++   EGD+ F
Sbjct  74   YRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFF  133

Query  120  P  120
            P
Sbjct  134  P  134

126) Psefu_4265 in NC_015556


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (364),  Expect = 4e-23, Method: Compositional matrix adjust.
 Identities = 60/145 (42%), Positives = 98/145 (68%), Gaps = 5/145 (3%)

Query  11   LCLIAALAENRVIGRDNQLPWHLPADLKHFKAMTLGKPIIMGRKTWDSLGRPLPGRLNLV  70
            + L+AA++ NRVIG + ++PW +P++ K F+ +T GK ++MGRKT +S+G+PLP R  LV
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  71   VSRQAGLQLEGAEVFATVEAAHQRAEAWAREQGVDEVMLIGGAQLYEQALPEADRLYLTR  130
            +SRQA  +  G  V +T+     +A A A E G +E+ + GGA++Y  ALP+A+ ++L+ 
Sbjct  68   ISRQANYRATGCVVVSTLS----HAIALASELG-NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  131  VALQPEGDAWFPAFDEAQWQRVECD  155
            V    EGDA FP ++E++ + V  +
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTE  147

127) dfrA in NC_012526


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (364),  Expect = 4e-23, Method: Compositional matrix adjust.
 Identities = 52/127 (41%), Positives = 87/127 (69%), Gaps = 1/127 (0%)

Query  10   IVAMTENRVIGKDGGMPWHLPADLAHFRRLSVGKPNIMGRKVYDSLGQALPGRTNIVLTR  69
            + AM  NRVIG++  +PW +P++   FRRL+ GK  +MGRK ++S+G++LP R  +V++R
Sbjct  11   VAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR  70

Query  70   NRGFQAPGCQVVHTPQEALDAAGD-APEIAILGGEEIYRLYLEQLTRVEMTLIHTSLEGD  128
            +  ++A GC VV T  +A+  A++ + E+ + GG EIY L L +   V ++ +H ++EGD
Sbjct  71   QANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGD  130

Query  129  TFFPELS  135
            +FFP L+
Sbjct  131  AFFPMLN  137

128) folA in NC_002927


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (362),  Expect = 5e-23, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  9    LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  68
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RNPAYgaagavvvgSLNAAIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  127
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  128  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  165
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

129) LHK_00787 in NC_012559


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (362),  Expect = 5e-23, Method: Compositional matrix adjust.
 Identities = 59/142 (42%), Positives = 94/142 (67%), Gaps = 1/142 (0%)

Query  9    LIAARARNGVIGLDNRMPWHLPEDLAYFKRVTLGKPVVMGRKTFESIGRPLPGRLNIVVT  68
            L+AA + N VIG +  +PW +P +   F+R+T GK VVMGRKTFESIG+PLP R  +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RNPDWQAAGVQVAHSLDaalalaaaaaPEEIMLIGGAELYRQALPQADVLYLTEIDAEFA  128
            R+++ +A+G  V  +L       A+   +E+ + GGAE+Y  ALP+A+ ++L+E++  F 
Sbjct  70   RQANYRATGCVVVSTLS-HAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  129  GDAFFPEVDLARWRIDREEAGQ  150
            GDAFFP ++ +   +   E+ Q
Sbjct  129  GDAFFPMLNETEFELVSTETIQ  150

130) folA in NC_013891


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (362),  Expect = 5e-23, Method: Compositional matrix adjust.
 Identities = 52/128 (41%), Positives = 96/128 (75%), Gaps = 0/128 (0%)

Query  14   IGKDNKMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIVLTRDTSLQLADA  73
            IG++ ++PW +PG+ ++F++ T GK +VMGRKT+ES+GK+LPNR T+V++R+++ + ++ 
Sbjct  20   IGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATGC  79

Query  74   DVIHSRDEVLALAKEQDEAIYIAGGAEIYRLFMDVADKLIVTKIDATFEADTAFPEVDWE  133
             V+ +  + +ALA E ++ +Y+AGGAEIY L +  A+ ++++ ++ TFE+D+ FP ++  
Sbjct  80   VVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNET  139

Query  134  NFTEVSRE  141
            +F  VS E
Sbjct  140  EFELVSTE  147

131) folA in NC_016808


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (361),  Expect = 6e-23, Method: Compositional matrix adjust.
 Identities = 54/125 (44%), Positives = 88/125 (71%), Gaps = 2/125 (1%)

Query  5    LIVAMTKNHVIGKDNQIPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNLVLS  64
            L+ AM  N+VIG++ +IPW +P++   FR+ T GK V+MGRKTFESIG+PLP+R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQP-YLHEGVIWQNSLESAVDFVKD-SPEILLIGGGELFKQYLHKADKLYLTEIQTELEG  122
            RQ+ Y   G +  ++L  A+ +  + + E+ + GG+E++   L  A+ ++L+E++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTFFP  127
            D+FFP
Sbjct  130  DAFFP  134

132) RPD_3353 in NC_007958


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =  100 bits (361),  Expect = 6e-23, Method: Compositional matrix adjust.
 Identities = 53/132 (41%), Positives = 94/132 (72%), Gaps = 5/132 (3%)

Query  23   VIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIVVTRDTHFQAAG  82
            VIG+G  IPW++ ++Q+ F++LT  K V+MGRKT++SIG+PLP R  +V++R+++++A+G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  83   VVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTEVHASPQGDTTF  142
             VV +++  A  +A +  +   + E+ V GG+EIY+  LP+A  + L+EVH + +GD+ F
Sbjct  79   CVVVSTLSHA--IALASEL---GNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFF  133

Query  143  PAIDPDQWEEVA  154
            P ++  + E V+
Sbjct  134  PMLNETEFELVS  145

133) Coch_0487 in NC_013162


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.6 bits (359),  Expect = 8e-23, Method: Compositional matrix adjust.
 Identities = 67/142 (48%), Positives = 101/142 (72%), Gaps = 1/142 (0%)

Query  4    LIAAVAENNAIGKGDQLLWHLPEDFKHFKRLTTGHCIIMGRKTFETFPKPLPNRIHIVIT  63
            L+AA++ N  IG+G ++ W +P + K F+RLT G  ++MGRKTFE++ KPLPNR  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  64   RQKGYakegavvvssveeaiekaLAIDPNPYVIGGGEIYAQALLFADAIELTRVHHTFAE  123
            RQ  Y   G VVVS++ +AI  A  ++ + YV GG+EIY+ AL  A+++ L+ VH+TF E
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF-E  128

Query  124  ADVFFPEFNREEWELVASERFE  145
            +D FFP +N  E ELV++E ++
Sbjct  129  GDAFFPMLNETEFELVSTETIQ  150

134) folA in NC_010804


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.6 bits (359),  Expect = 9e-23, Method: Compositional matrix adjust.
 Identities = 65/161 (41%), Positives = 110/161 (69%), Gaps = 5/161 (3%)

Query  6    LIVARARNGIIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVT  65
            L+ A + N +IG + ++PWK+P +  +F+R T G  +VMGRKT ESIG+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDASRRFDGCDTVTSladalalaardgaaeaflIGGAQLYAEGLAQADKLIVTEIDADFE  125
            R+A+ R  GC  V++L++A+ALA+  G       GGA++Y+ +L++A+ ++++E++  FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVA-GGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  126  GDASFPAPDPAQWQEVSRDAHQAATPNTFGYAFVVYARKRG  166
            GDA FP  + ++ + VS ++ QA  P    Y+  VYAR+ G
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

135) dfrA in NC_015844


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.4 bits (358),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 55/124 (45%), Positives = 85/124 (69%), Gaps = 6/124 (4%)

Query  24   WHLPDDFKRFKSLTSGHTIVMGRKTYESFPKPLPNRKHVIITRDKNYTVDYDVCVVVHSL  83
            W +P++ K F+ LT G  +VMGRKT+ES+ KPLPNR  ++I+R+ NY      CVVV +L
Sbjct  28   WKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRA--TGCVVVSTL  85

Query  84   EEALELVKD--EDLSFIIGGGEIYKLAMEHANKIELTRVHGIFEDADTFFPEIPESQWEL  141
             +A+ L  +  ++L ++ GG+EIY LA+ HA+ + L+ VH  FE +D+FFP + E++ EL
Sbjct  86   SHAIALASELGNEL-YVAGGAEIYTLALPHAHGVFLSEVHQTFE-GDAFFPMLNETEFEL  143

Query  142  ASEQ  145
             S +
Sbjct  144  VSTE  147

136) NT08PM_1502 in NC_017764


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.4 bits (358),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 53/125 (43%), Positives = 88/125 (71%), Gaps = 2/125 (1%)

Query  5    LIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNLVLS  64
            L+ AM  N+VIG++ ++PW +P++   FR+ T GK V+MGRKTFESIG+PLP+R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQP-YLHEGVIWQNSLESAVDFVKD-SPEILLIGGGELFKQYLHKADKLYLTEIQTELEG  122
            RQ+ Y   G +  ++L  A+ +  + + E+ + GG+E++   L  A+ ++L+E++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTFFP  127
            D+FFP
Sbjct  130  DAFFP  134

137) folA in NC_017027


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.4 bits (358),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 53/125 (43%), Positives = 88/125 (71%), Gaps = 2/125 (1%)

Query  5    LIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNLVLS  64
            L+ AM  N+VIG++ ++PW +P++   FR+ T GK V+MGRKTFESIG+PLP+R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQP-YLHEGVIWQNSLESAVDFVKD-SPEILLIGGGELFKQYLHKADKLYLTEIQTELEG  122
            RQ+ Y   G +  ++L  A+ +  + + E+ + GG+E++   L  A+ ++L+E++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTFFP  127
            D+FFP
Sbjct  130  DAFFP  134

138) folA in NC_002663


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.4 bits (358),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 53/125 (43%), Positives = 88/125 (71%), Gaps = 2/125 (1%)

Query  5    LIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNLVLS  64
            L+ AM  N+VIG++ ++PW +P++   FR+ T GK V+MGRKTFESIG+PLP+R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQP-YLHEGVIWQNSLESAVDFVKD-SPEILLIGGGELFKQYLHKADKLYLTEIQTELEG  122
            RQ+ Y   G +  ++L  A+ +  + + E+ + GG+E++   L  A+ ++L+E++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTFFP  127
            D+FFP
Sbjct  130  DAFFP  134

139) Sput200_0983 in NC_017566


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.4 bits (358),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 53/124 (43%), Positives = 87/124 (71%), Gaps = 1/124 (0%)

Query  14   VIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIVISRQANLVIDG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKT+ESIG+PLP RH +VISRQAN    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGD-CEELVVVGGGQLYTELLPQADILYLTQINLDVEGDTYFPEWDA  132
               V+++  A   A++  +EL V GG+++YT  LP+A+ ++L++++   EGD++FP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  CDWQ  136
             + +
Sbjct  139  TEFE  142

140) folA in NC_012695


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 99.1 bits (357),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 68/161 (43%), Positives = 105/161 (66%), Gaps = 5/161 (3%)

Query  6    LIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVT  65
            L+ A + N VIG +  +PWK+P +  +F+R T G  +VMGRKT ESIG+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDAARRFDGCDTVTSledalalaardgaaeaflIGGAQLYEEGLRHADKLIVTEIDQDFE  125
            R+A  R  GC  V++L +A+ALA+  G       GGA++Y  +L HA+ ++++E++Q FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVA-GGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  126  GDASFPAPDPAQWEAVSRDTHRAAQPNDFTYAFVVYRRRRA  166
            GDA FP  + ++ E VS +T +A  P    Y+  VY RR +
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

141) N175_13720 in NC_022223


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =   99 bits (360),  Expect = 8e-23, Method: Compositional matrix adjust.
 Identities = 61/152 (41%), Positives = 105/152 (70%), Gaps = 2/152 (1%)

Query  3    ISMIAAMADNRIIGKNNQMPWHLPADFAWFKRCTLGKPVIMGRKTYESIGRPLPGRHNIV  62
            I ++AAM+ NR+IG+  ++PW +P++   F+R T GK V+MGRKT+ESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLAIEGVSIVSSIEEAIEVAGHV-DEVMIIGGGSIYQACMPQANKLYLTFIDLNI  121
            ISR+A+    G  +VS++ +AI +A+++ +E+ + GG+ IY   +P+A+ ++L+ ++  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  EGDTQFPEWG-SEWQEVHREMYQADDKNAHNM  152
            EGD+ FP    +E + V  E  QA    +H++
Sbjct  128  EGDAFFPMLNETEFELVSTETIQAVIPYTHSV  159

142) VAA_01677 in NC_015633


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score =   99 bits (360),  Expect = 8e-23, Method: Compositional matrix adjust.
 Identities = 61/152 (41%), Positives = 105/152 (70%), Gaps = 2/152 (1%)

Query  3    ISMIAAMADNRIIGKNNQMPWHLPADFAWFKRCTLGKPVIMGRKTYESIGRPLPGRHNIV  62
            I ++AAM+ NR+IG+  ++PW +P++   F+R T GK V+MGRKT+ESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLAIEGVSIVSSIEEAIEVAGHV-DEVMIIGGGSIYQACMPQANKLYLTFIDLNI  121
            ISR+A+    G  +VS++ +AI +A+++ +E+ + GG+ IY   +P+A+ ++L+ ++  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  EGDTQFPEWG-SEWQEVHREMYQADDKNAHNM  152
            EGD+ FP    +E + V  E  QA    +H++
Sbjct  128  EGDAFFPMLNETEFELVSTETIQAVIPYTHSV  159

143) folA in NC_018828


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.9 bits (356),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 99/158 (63%), Gaps = 3/158 (1%)

Query  11   LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  70
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  71   RNPAYgaagavvvgSLDAAIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  129
            R++ Y A+G VVV++L  AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  130  DAFFPPLPAGQWRETQRAAQLAENGLRYDFVEYERVAG  167
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

144) VVMO6_02662 in NC_014965


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.9 bits (356),  Expect = 1e-22, Method: Compositional matrix adjust.
 Identities = 54/131 (42%), Positives = 96/131 (74%), Gaps = 1/131 (0%)

Query  3    ISMIAAMAKQRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYDSIGRPLPGRLNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDESLVIEGVTMANSIAHALALAGD-ADEVMIIGGGSIYAECLPKADKLYLTFIDATI  121
            ISR+ +    G  + ++++HA+ALA++ ++E+ + GG+ IY+  LP A+ ++L+ ++ T+
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFPDWGE  132
            +GD+ FP   E
Sbjct  128  EGDAFFPMLNE  138

145) VV0475 in NC_005139


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.9 bits (356),  Expect = 2e-22, Method: Compositional matrix adjust.
 Identities = 54/131 (42%), Positives = 96/131 (74%), Gaps = 1/131 (0%)

Query  3    ISMIAAMAKQRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYDSIGRPLPGRLNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDESLVIEGVTMANSIAHALALAGD-ADEVMIIGGGSIYAECLPKADKLYLTFIDATI  121
            ISR+ +    G  + ++++HA+ALA++ ++E+ + GG+ IY+  LP A+ ++L+ ++ T+
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFPDWGE  132
            +GD+ FP   E
Sbjct  128  EGDAFFPMLNE  138

146) VV1_0666 in NC_004459


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.9 bits (356),  Expect = 2e-22, Method: Compositional matrix adjust.
 Identities = 53/131 (41%), Positives = 96/131 (74%), Gaps = 1/131 (0%)

Query  3    ISMIAAMAKQRIIGKDNQMPWHLPADFAWFKRCTMGKPIVMGRKTYDSIGRPLPGRLNIV  62
            I ++AAM+ +R+IG++ ++PW +P++   F+R T GK +VMGRKT++SIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDESLVIEGVTMANSIAHALALAGD-ADEVMIIGGGSIYAECLPKADKLYLTFIDATI  121
            ISR+ +    G  + ++++HA+ALA++ ++E+ + GG+ IY+  LP A+ ++L+ ++ T+
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFPDWGE  132
            +GD+ FP   E
Sbjct  128  EGDAFFPMLNE  138

147) Mrad2831_4526 in NC_010505


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.6 bits (355),  Expect = 2e-22, Method: Compositional matrix adjust.
 Identities = 56/123 (46%), Positives = 84/123 (69%), Gaps = 3/123 (2%)

Query  20   VIGRDNGLAWHLSSDLKRFKALTMGKPMLMGRRTWDSIGRPLPGRRTLVLTRDTGFRAEG  79
            VIG +  ++W ++++ K F+ LT GK ++MGR+T +SIG+PLP R+TLV++R++ +RA G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  80   VETVHDWDSALAAA---GAELMVVGGAEIYALALPHADRLHLTEVEAEPAGDVRFPAFDR  136
               V     A+A A   G EL V GGAEIY+LALPHA+ + L+EV+    GD  FP ++ 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  137  ARF  139
            + F
Sbjct  139  TEF  141

148) Snov_3092 in NC_014217


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.3 bits (354),  Expect = 2e-22, Method: Compositional matrix adjust.
 Identities = 66/144 (46%), Positives = 100/144 (70%), Gaps = 6/144 (4%)

Query  6    IIAAVAENGVIGRGDDLPWHISGDLKRFRTITWGKPILMGRKTFMSIGKPLPGRTSIVVT  65
            ++AA++ N VIG G ++PW I+G+ K FR +T GK ++MGRKTF SIGKPLP R ++V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDTGFAVPEGVLVVPSLPAALDRGALEAERLEVDEMAVIGGAQLYAQALPHASRLRLTEV  125
            R++ +  + G +VV++L+ A+   AL +E L  +E+ V GGA++Y+ ALPHA  + L+EV
Sbjct  70   RQANYR-ATGCVVVSTLSHAI---ALASE-LG-NELYVAGGAEIYTLALPHAHGVFLSEV  123

Query  126  LGEPEGDIFFPAFAQDEWREVSRE  149
                EGD FFP + + E   VS E
Sbjct  124  HQTFEGDAFFPMLNETEFELVSTE  147

149) folA in NC_009656


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.3 bits (354),  Expect = 2e-22, Method: Compositional matrix adjust.
 Identities = 59/142 (42%), Positives = 96/142 (68%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFASLDAALVRaeewaqaedadeLMLIGGAQLYAEALPRAERLYLTRVG  126
            RQA     G  V ++L  A+        +E ++EL + GGA++Y+ ALP+A+ ++L+ V 
Sbjct  70   RQANYRATGCVVVSTLSHAIA-----LASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDDAGWRLASS  148
             + EGDAFFP ++++   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

150) P700755_003057 in NC_018721


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.1 bits (353),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 60/142 (43%), Positives = 98/142 (70%), Gaps = 1/142 (0%)

Query  1    MKITLVAAAAENNALGKDNDLIWRLPDDFKRFKALTSYHHIIMGRKTFESFPKPLPNRKH  60
            ++I LVAA + N  +G++ ++ W++P++ K F+ LT    ++MGRKTFES+ KPLPNR  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   VVITRQENYKNETIEVVHSLEEAIQFSSTeeeif-iigggeiYKQALPFTDKIELTRVHG  119
            +VI+RQ NY+     VV +L +AI ++S   + + + GG+EIY  ALP ++ + L+ VH 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EFEADTFFPEIDEKKWDLVNSE  141
             FE+D+FFP ++E   +LV++E
Sbjct  126  TFEGDAFFPMLNETEFELVSTE  147

151) CGSHiEE_07515 in NC_009566


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 98.1 bits (353),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 92/134 (69%), Gaps = 2/134 (1%)

Query  5    LIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVLS  64
            L+ A   N VIG++ ++PW +P++   FR+ T GK V+MGRKTFESIG+PLP+R  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQL-FEHDGVVWKGSLESAVDFVRDF-DEIMLIGGGELFKQYLPKADKLYLTQIQTELDG  122
            RQ  +   G V  ++L  A+ +  ++ +E+ + GG+E++   LP A+ ++L++++  ++G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTFFPQLNWEEWEI  136
            D+FFP LN  E E+
Sbjct  130  DAFFPMLNETEFEL  143

152) K734_02390 in NC_021286


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.8 bits (352),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 56/132 (43%), Positives = 95/132 (72%), Gaps = 4/132 (3%)

Query  1    MKISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKN  60
            ++I LV AM+ NRVIG++ ++PW +P+E + F+++T GK +VMGR+TFESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLSRRTDRSENQDSQVVWVSGVQQAIAAAGPV-EELMIIGGGKIYEKFLPLADRLYVTK  119
            +V+SR+++    + +  V VS + +AIA A+ + +EL + GG+ IY   LP A+ ++++ 
Sbjct  66   LVISRQAN---YRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSE  122

Query  120  IELNVEGDTYFP  131
            ++   EGD++FP
Sbjct  123  VHQTFEGDAFFP  134

153) folA in NC_006512


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.8 bits (352),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 56/132 (43%), Positives = 95/132 (72%), Gaps = 4/132 (3%)

Query  1    MKISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKN  60
            ++I LV AM+ NRVIG++ ++PW +P+E + F+++T GK +VMGR+TFESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLSRRTDRSENQDSQVVWVSGVQQAIAAAGPV-EELMIIGGGKIYEKFLPLADRLYVTK  119
            +V+SR+++    + +  V VS + +AIA A+ + +EL + GG+ IY   LP A+ ++++ 
Sbjct  66   LVISRQAN---YRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSE  122

Query  120  IELNVEGDTYFP  131
            ++   EGD++FP
Sbjct  123  VHQTFEGDAFFP  134

154) Nham_2729 in NC_007964


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.8 bits (352),  Expect = 3e-22, Method: Compositional matrix adjust.
 Identities = 55/137 (41%), Positives = 95/137 (70%), Gaps = 5/137 (3%)

Query  11   IVLVVAVAESGVIGQRNQIPWRLKADQQRFKAITMGKPIVMGRKTFDSLRRPLPGRTNIV  70
            I LV A++ + VIG+  +IPW++ ++Q+ F+ +T GK +VMGRKTF+S+ +PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  71   ITRDPDFAAVGAVATRSLADALAVAKGDALRRSVTEIAVIGGAEIYAASMPVADRLEVTE  130
            I+R++++ A G V   +L++A+A+A   +      E+ V GGAEIY+ ++P A+ + ++E
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  131  VHAGVDGDAVFPAIDPS  147
            VH   +GDA FP ++ +
Sbjct  123  VHQTFEGDAFFPMLNET  139

155) VEJY3_01630 in NC_016613


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.3 bits (350),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 51/125 (41%), Positives = 92/125 (74%), Gaps = 1/125 (0%)

Query  5    MIAAMADNRIIGKDNQMPWHLPADFVWFKRCTMGKPVVMGRKTYESIGRPLPGRLNIVIS  64
            ++AAM+ NR+IG++ ++PW +P++   F+R T GK VVMGRKT+ESIG+PLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RDESLSIEGVTTVTSIDQALEVAGDVEEVMIIGGGA-IYSACLPLATKLYVTHIEAAIEG  123
            R+ +    G   V+++ +A+ +A+++ + + ++GGA IY+  LP A  +++++++ ++EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTQFP  128
            D+ FP
Sbjct  130  DAFFP  134

156) Ping_1045 in NC_008709


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.0 bits (349),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 54/129 (42%), Positives = 89/129 (69%), Gaps = 1/129 (0%)

Query  1    MKISMIVAMSENRVIGLDNKMPWHLPADLMFFKRVTLGKPIIMGRKTFESIGRPLPGRKN  60
            ++I ++ AM+ NRVIG + ++PW +P++  +F+R+T GK ++MGRKTFESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLSRDKNLHIEGVCCVQTVEQALALVED-CDEVMVIGGATIYEQFLPQASRLYITFIDL  119
            +V+SR+ N +  G   V T+ +A+AL  +  +E+ V GGA IY   LP+A  ++++ ++ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  KTAGDTHFP  128
               GD+ FP
Sbjct  126  TFEGDAFFP  134

157) Rpdx1_1866 in NC_014834


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.0 bits (349),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 63/152 (42%), Positives = 101/152 (67%), Gaps = 5/152 (3%)

Query  1    MVSGQVAIVLVVAVADNGVIGKGNAIPWRLKSDLQRFKQLTLNKPVIMGRKTYQSIGRPL  60
            M S  V I LV A++ N VIG+G  IPW++ ++ + F++LT  K V+MGRKT++SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PGRTNIVVTRDLCFTARGVVVASSFDGAEQIARGDALRRAATEIAVIGGAEIYAYWLPRA  120
            P R  +V++R+  + A G VV S++  ++ IA +  L   + E+ V GGAEIY+  LP+A
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTL--SHAIALASEL---GNELYVAGGAEIYTLALPHA  115

Query  121  TRLELTEVHARPEGDTCFPAIDPAQWHEVARD  152
              + L+EVH   EGD+ FP ++ ++ + V+ +
Sbjct  116  HGVFLSEVHQTFEGDAFFPMLNETEFELVSTE  147

158) Sbal175_3293 in NC_017571


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.0 bits (349),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 55/134 (42%), Positives = 89/134 (67%), Gaps = 3/134 (2%)

Query  14   VIGKENKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQTDLVIEG  73
            VIG+  ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQ++    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKLEVEGDTFFPHWDD  132
               V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++    EGD+FFP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  GTWK--ETESLSSI  144
                   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

159) Sbal223_3318 in NC_011663


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.0 bits (349),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 55/134 (42%), Positives = 89/134 (67%), Gaps = 3/134 (2%)

Query  14   VIGKENKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQTDLVIEG  73
            VIG+  ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQ++    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKLEVEGDTFFPHWDD  132
               V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++    EGD+FFP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  GTWK--ETESLSSI  144
                   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

160) Dfer_4811 in NC_013037


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 97.0 bits (349),  Expect = 5e-22, Method: Compositional matrix adjust.
 Identities = 53/131 (41%), Positives = 93/131 (71%), Gaps = 1/131 (0%)

Query  18   MKISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTS  77
            ++I ++ A + N  IG + ++ W+++++ K F++LT G  ++MGRKTFESIGKPLP R +
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  78   IVITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVH  137
            +VI+R+AN+   G VVV +L +A+  A E+ ++E+ + GG+EIY  + + A  ++L+ VH
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASEL-GNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  138  TSVVGDTFFSI  148
             +  GD+FF++
Sbjct  125  QTFEGDAFFPM  135

161) folA in NC_002928


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.8 bits (348),  Expect = 7e-22, Method: Compositional matrix adjust.
 Identities = 65/158 (42%), Positives = 98/158 (63%), Gaps = 3/158 (1%)

Query  11   LVVAYSTNGVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  70
            LV A ++N VIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  71   RNPAYgaagavvvgSLDAAIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  129
            R++ Y A+G VVV++L  AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  130  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  167
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

162) folA in NC_017454


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.8 bits (348),  Expect = 7e-22, Method: Compositional matrix adjust.
 Identities = 67/161 (42%), Positives = 99/161 (62%), Gaps = 6/161 (3%)

Query  1    MRITLIAAMAENRVIGNRGAIPWHLPDDLARFRAITLGHPVLMGRRTFESIGRPLPGRLN  60
            +RI L+AAM+ NRVIGN   IPW +P++   FR +T G  V+MGR+TFESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLSHREGYAPPGCLVard-laaalelardaaelFVCGGGELYREALPLADQILLTLVQG  119
            +V+S++  Y + GC+V      A    +  + EL+V GG+E+Y  ALP A+ ++L+ V+ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EFPGDVTFP---EVPADFVETAREEGVGGPAHLFLTYERRK  157
             F GD  FP   E   ++V T   ++V   +H    Y RR+
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAVIPYTH--SVYARRN  164

163) bgla_1g19960 in NC_015381


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.5 bits (347),  Expect = 7e-22, Method: Compositional matrix adjust.
 Identities = 68/159 (43%), Positives = 101/159 (64%), Gaps = 9/159 (5%)

Query  6    QIVMVAAMAANRVIGFGKDIPWTIPGEQKRFRELTMGQLLVMGRLTFESIGRPLPGRDVV  65
            +I +VAAM+ANRVIG G +IPW IPGEQK FR LT G+++VMGR TFESIG+PLP R+ +
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  66   VLSSRDEALAGARRAAC--FEALVDII--RDDPRERVLIGGGQQIYERFLPFADVVHLTE  121
            V+S +    A  R ++C    +L + I    +  + + ++GG +IY   LP A+ V L+E
Sbjct  67   VISRQ----ANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSE  122

Query  122  IDLQVPGDTFFPTLP-ARFTAVDRVEIDGAVAHAFVTYA  159
            ++    GD+FFP L  + F  V    I++ ++ +   YA
Sbjct  123  VHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYA  161

164) Sputcn32_0984 in NC_009438


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.0 bits (345),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 53/124 (43%), Positives = 86/124 (70%), Gaps = 1/124 (0%)

Query  14   VIGKDNKMPWYLPEDLKHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLVIEG  73
            VIG++ ++PW +P + K F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVIMGGGQLYRELLPQADILYLTQINLDVEGDTYFPEWDA  132
               V+++  A   A+E  +EL + GG+++Y   LP+A+ ++L++++   EGD++FP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  RDWQ  136
             + +
Sbjct  139  TEFE  142

165) Sputw3181_3183 in NC_008750


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.0 bits (345),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 53/124 (43%), Positives = 86/124 (70%), Gaps = 1/124 (0%)

Query  14   VIGKDNKMPWYLPEDLKHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLVIEG  73
            VIG++ ++PW +P + K F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVIMGGGQLYRELLPQADILYLTQINLDVEGDTYFPEWDA  132
               V+++  A   A+E  +EL + GG+++Y   LP+A+ ++L++++   EGD++FP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  RDWQ  136
             + +
Sbjct  139  TEFE  142

166) folA in NC_002939


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.0 bits (345),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 67/161 (42%), Positives = 99/161 (62%), Gaps = 6/161 (3%)

Query  1    MRITLIAAMAENRVIGNRGAIPWHLPDDLARFRAITLGHPVLMGRRTFESIGRPLPGRLN  60
            +RI L+AAM+ NRVIGN   IPW +P++   FR +T G  V+MGR+TFESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVLSHREGYAPPGCLVard-laaalelardaaelFVCGGGELYREALPLADRILLTLVQG  119
            +V+S++  Y + GC+V      A    +  + EL+V GG+E+Y  ALP A+ ++L+ V+ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  120  EFPGDVTFP---EVPADFVETAREEGVGGPAHLFLTYERRK  157
             F GD  FP   E   ++V T   ++V   +H    Y RR+
Sbjct  126  TFEGDAFFPMLNETEFELVSTETIQAVIPYTH--SVYARRN  164

167) folA in NC_012751


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.0 bits (345),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 96/139 (70%), Gaps = 2/139 (1%)

Query  5    LIAAMAQNRVIGLNNKMPWHLPLDFAWFKKNTLHKPVIMGRKTFDSLGRALPGRMNIVMT  64
            L+AAM+ NRVIG   ++PW +P +   F++ T  K V+MGRKTF+S+G++LP R  +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQGI-ASPGVIGVSSMEKALKAAQD-APEVMVIGGAEIYRQFLPQANRLYLTEVLKNIQG  122
            RQ+   + G + VS++  A+  A + + E+ V GGAEIY   LP+A+ ++L+EV + ++G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTYFPEYEQQQWEMVFQES  141
            D++FP  ++ + E+V  E+
Sbjct  130  DAFFPMLNETEFELVSTET  148

168) PSEBR_a5358 in NC_015379


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 96.0 bits (345),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 61/151 (41%), Positives = 99/151 (66%), Gaps = 5/151 (3%)

Query  2    NKTLPLSLIAALGENRVIGIDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPG  61
            + ++ + L+AA+G NRVIG + ++PW +PG+ K F+  T GK ++MGRKT +S+G+PLP 
Sbjct  3    SESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPN  62

Query  62   RLNIVVSRQSGLVLEGAQVFSTLeaavaraeawaleQGVDELMLIGGAQLYAQALEQADR  121
            R  +V+SRQ+     G  V STL  A+A A   +     +EL + GGA++Y+ AL +A+ 
Sbjct  63   RHTLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHG  117

Query  122  LYLTRVALSPEGDAWFPAFDASQWTLVSNQP  152
            ++L+ V  + EGDA FP ++ ++  LVS + 
Sbjct  118  VFLSEVHQTFEGDAFFPMLNETEFELVSTET  148

169) Celf_1550 in NC_015514


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 58/135 (43%), Positives = 88/135 (66%), Gaps = 5/135 (3%)

Query  5    LVWAQTPAGVIGVDNTLPWHVPEDQARFRRLTTGHPVVMGRATWESLPERFRPLPGRRNV  64
            LV A  +  VIG +  +PW +P +Q  FRRLT G  VVMGR T ES+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  65   VLSRDAAYDAPGAEVVGSLDEALALVGE--AETWVVGGGAVYALALPLAERVEVTFVDRD  122
            V+SR+A Y A G  VV++L +A+AL +E   E  V GG+ +Y+LALP A+ V ++ V++ 
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  VPGDTYAPVLDAADW  137
              GD++ P+L+ ++ 
Sbjct  127  FEGDAFFPMLNETEF  141

170) folA in NC_018829


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  9    LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  68
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RNPAYDaagavvvgslaaaIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  127
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  128  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  165
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

171) folA in NC_018518


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  11   LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  70
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  71   RNPAYDaagavvvgslaaaIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  129
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  130  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  167
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

172) folA in NC_017223


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  11   LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  70
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  71   RNPAYDaagavvvgslaaaIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  129
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  130  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  167
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

173) folA in NC_002929


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 1e-21, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  11   LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  70
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  71   RNPAYDaagavvvgslaaaIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  129
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  130  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  167
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

174) folA in NC_019382


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.7 bits (344),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 66/158 (42%), Positives = 100/158 (64%), Gaps = 3/158 (1%)

Query  9    LVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNIVIT  68
            LV A ++NRVIG +  +PWK+PG+   F+R T G  ++MGR+T ES+G+PLP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RNPAYEaagavvvgslaaaIQACGDAAVA-CVIGGAQIYAQALPLAQRVVATEVHAEIEG  127
            R++ Y A+G VVV++L+ AI   ++ +    V GGA+IY+ ALP A+ V  +EVH  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  128  DAFFPPLPAGQWRETQRAAQPAENGLRYDFVEYERVAG  165
            DAFFP L   +      +++  +  + Y    Y R  G
Sbjct  130  DAFFPMLNETEFELV--STETIQAVIPYTHSVYARRNG  165

175) folA in NC_007434


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.4 bits (343),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 66/161 (41%), Positives = 104/161 (65%), Gaps = 5/161 (3%)

Query  6    LIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVT  65
            L+ A + N VIG +  +PWK+P +  +F+R T G  +VMGRKT ESIG+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDAARRFDGCdtatslddalalaardgaaeaflIGGAQLYEEGLRHADKLIVTEIDQDFE  125
            R+A  R  GC   ++L +A+ALA+  G       GGA++Y  +L HA+ ++++E++Q FE
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVA-GGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  126  GDASFPAPDPAQWEAVSRDAHRAAQPNDFTYAFVVYRRRRA  166
            GDA FP  + ++ E VS ++ +A  P    Y+  VY RR +
Sbjct  129  GDAFFPMLNETEFELVSTETIQAVIP----YTHSVYARRNG  165

176) Sbal117_1071 in NC_017579


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.4 bits (343),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 89/134 (67%), Gaps = 3/134 (2%)

Query  14   VIGKENKMPWHLPEDLRHFKGMTLGKPVLMGRKTFESIGRPLPGRHNIVISRQTDLVIEG  73
            VIG+  ++PW +P + + F+ +T GK V+MGRKTFESIG+PLP RH +VISRQ++    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKLEVEGDTFFPHWDD  132
               V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++    EGD+FFP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  GTWK--ETESLSSI  144
                   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

177) Sbal_0972 in NC_009052


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.4 bits (343),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 89/134 (67%), Gaps = 3/134 (2%)

Query  14   VIGKENKMPWHLPEDLRHFKGMTLGKPVLMGRKTFESIGRPLPGRHNIVISRQTDLVIEG  73
            VIG+  ++PW +P + + F+ +T GK V+MGRKTFESIG+PLP RH +VISRQ++    G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFDAAKQAAGE-CEELVVIGGGQLYAELLPYADTLYLTQIKLEVEGDTFFPHWDD  132
               V+++  A   A+E  +EL V GG+++Y+  LP A+ ++L+++    EGD+FFP  ++
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  GTWK--ETESLSSI  144
                   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

178) Mext_2659 in NC_010172


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.2 bits (342),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 64/136 (48%), Positives = 100/136 (74%), Gaps = 2/136 (1%)

Query  5    RISLVAAIARNGVIGRDNSLAWRLSSDLKRFRALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            RI LVAA++ N VIG + +++W+++++ K FR LT GK ++MGRKT +SIG+PLP R++L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VITRDRSLALPDVTVVHdwdealaaagd--delMVVGGAEIYRLALPHADRLHLTEVDAA  122
            VI+R+ +    +  VV    +A+A A++  +EL V GGAEIY LALPHA+ + L+EV+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  PEGDAYFPPFDRALFH  138
             EGDA+FP ++ + F+
Sbjct  127  FEGDAFFPMLNETEFE  142

179) VS_0367 in NC_011753


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 95.2 bits (342),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 54/131 (42%), Positives = 89/131 (68%), Gaps = 1/131 (0%)

Query  3    ISMIAAMANNRVIGKDNQMPWHLPADFAWFKRSTMGKPVVMGRKTYDSIGRPLPGRLNVV  62
            I ++AAM+ NRVIG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDESLEIGGVTTVTSIEKALELVSDV-DEVMIIGGGSIYESCLPKANKLYLTYIDFDV  121
            ISR+ +    G   V+++  A+ L S++ +E+ + GG+ IY   LP A+ ++L+ ++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFPDWGE  132
            +GD+ FP   E
Sbjct  128  EGDAFFPMLNE  138

180) Mchl_2886 in NC_011757


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.9 bits (341),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 63/135 (47%), Positives = 100/135 (75%), Gaps = 2/135 (1%)

Query  5    RISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            RI LVAA++ N VIG + +++W+++++ K F+ LT GK ++MGRKT +SIG+PLP R++L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VITRDRSLTLSDVTVVHdwdealaaagd--delMVVGGAEIYRLALPHADRLHLTEVDAA  122
            VI+R+ +   ++  VV    +A+A A++  +EL V GGAEIY LALPHA+ + L+EV+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  PEGDAYFPPFDRSLF  137
             EGDA+FP ++ + F
Sbjct  127  FEGDAFFPMLNETEF  141

181) Varpa_1813 in NC_014931


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.9 bits (341),  Expect = 2e-21, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 91/139 (66%), Gaps = 4/139 (2%)

Query  5    RINLIYARAANGVIGVNGTIPWHLPEDMAHFKQKTAGAPVIMGRKTWDSLPPRFRPLPGR  64
            RI L+ A +AN VIG    IPW +P +   F++ T G  V+MGRKT +S+    +PLP R
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNR  63

Query  65   QNIVVTRQADWRAEGALPVGNLRDALSLCAEAASPEVWVIGGAQIYAEAEPLAQRAVVTE  124
            + +V++RQA+ RA G + V+ L +A++L +E ++ E+ V GGA+IY+ A P A+   ++E
Sbjct  64   HTLVISRQANYRATGCVVVSTLSHAIALASELGN-ELYVAGGAEIYTLALPHAHGVFLSE  122

Query  125  IARDYEGDAHAPVLDGAAW  143
            + + +EGDA  P+L+ +  
Sbjct  123  VHQTFEGDAFFPMLNETEF  141

182) dfrA in NC_012808


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.7 bits (340),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 63/135 (47%), Positives = 100/135 (75%), Gaps = 2/135 (1%)

Query  5    RISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            RI LVAA++ N VIG + +++W+++++ K F+ LT GK ++MGRKT +SIG+PLP R++L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VITRDRSLALSDVTVVHdwdealaaagd--delMVVGGAEIYRLALPHADRLHLTEVDAA  122
            VI+R+ +   ++  VV    +A+A A++  +EL V GGAEIY LALPHA+ + L+EV+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  PEGDAYFPPFDRSLF  137
             EGDA+FP ++ + F
Sbjct  127  FEGDAFFPMLNETEF  141

183) Celal_2140 in NC_014934


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.7 bits (340),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 49/117 (42%), Positives = 83/117 (71%), Gaps = 2/117 (1%)

Query  6    LIAAAADNNALGKDNDLLWHLPDDFKRFKALTTGYPIVMGRKTFESFPKPLPNRTHIIIT  65
            L+AA + N  +G++ ++ W +P++ K F+ LT G  +VMGRKTFES+ KPLPNR  ++I+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDKNYKTVFENCKVVHSLEEALIVGNQLNNAVFIIGGGEIYALGLEKATCIELTRVH  122
            R+ NY++    C VV +L +A+ ++++L N +++ GG+EIY+L+L  A  + L+ VH
Sbjct  70   RQANYRAT--GCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

184) dfrA [H] in NC_019902


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.7 bits (340),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 59/142 (42%), Positives = 95/142 (67%), Gaps = 3/142 (2%)

Query  10   RLEIIVAMDPDRVIGRDNALPWHLPDDLRHFRRLTTGHTVVMGRRTHESIGRPLPDRRNL  69
            R+ ++ AM+++RVIG +  +PW +P++ + FRRLT G  VVMGR+T ESIG+PLP+R+ L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  70   VLTRQPGWaapgvevfaafeealaaaD--SGRVFVIGGAELFKAALPRAAVLHLTRVHDR  127
            V++RQ+   A G  V +++ +A+A A   +  ++V GGAE++  ALP+A  + L+ VH+ 
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  128  HPGDVRFPAFGD-DWTLVWEED  148
              GD  FP + + +  LV  E 
Sbjct  127  FEGDAFFPMLNETEFELVSTET  148

185) C380_08895 in NC_018708


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.4 bits (339),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 55/134 (42%), Positives = 92/134 (69%), Gaps = 4/134 (2%)

Query  3    LHLIYARAANGVIGKDNRLPWHIPEDMAHFKQLTQGCPVVMGRKTWDSLPPRFRPLPGRT  62
            + L+ A +AN VIG++  +PW IP +   F++LT+G  VVMGRKT +S+    +PLP R 
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRH  64

Query  63   NIVVTRQGDWQAEGAHRAGSLAEALAL-CDTGKTVWIIGGAQIYAEALPLADCVEVTEIA  121
             +V++RQ++ +A G    ++L++A+AL  + G+ + + GGA+IY+ ALP A+ V ++E+ 
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  122  QDFDGDAYAPVLGA  135
            Q F+GDA+ P+L  
Sbjct  125  QTFEGDAFFPMLNE  138

186) vfu_A03075 in NC_016602


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.4 bits (339),  Expect = 3e-21, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 93/127 (74%), Gaps = 1/127 (0%)

Query  3    ISMIAAMASNRIIGKDNQMPWHLPADFVWFKRCTMGKPVVMGRKTYQSIGRPLPGRQNIV  62
            I ++AAM++NR+IG++ ++PW +P++   F+R T GK VVMGRKT++SIG+PLP R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRDASLVIDGVDVVTSIDAALDKAGA-ADEVMIIGGGSIYTECLPRAGKLYITLIDADL  121
            ISR+A+    G  VV+++  A+  A+  ++E+ + GG+ IYT  LP+A  ++++ ++  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  122  DGDTQFP  128
            +GD+ FP
Sbjct  128  EGDAFFP  134

187) dfrA in NC_012988


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 94.4 bits (339),  Expect = 4e-21, Method: Compositional matrix adjust.
 Identities = 63/135 (47%), Positives = 99/135 (74%), Gaps = 2/135 (1%)

Query  5    RISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            RI LVAA++ N VIG + +++W+++++ K F+ LT GK ++MGRKT +SIG+PLP R++L
Sbjct  7    RIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTL  66

Query  65   VITRDRSLTLPDVTVVHdwdealaaagd--delMVVGGAEIYRLALPHADRLHLTEVDAA  122
            VI+R+ +    +  VV    +A+A A++  +EL V GGAEIY LALPHA+ + L+EV+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  123  PEGDAYFPPFDRALF  137
             EGDA+FP ++ + F
Sbjct  127  FEGDAFFPMLNETEF  141

188) Mesil_0096 in NC_014212


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 93.3 bits (335),  Expect = 7e-21, Method: Compositional matrix adjust.
 Identities = 60/139 (44%), Positives = 99/139 (72%), Gaps = 6/139 (4%)

Query  2    DSPSLTLIAAMDRNRAIGKGGRLPWHLPDDLRRFKALTLGHTVLMGRKTFESIGRPLPGR  61
            +S  + L+AAM+ NR IG+G  +PW +P++ + F+ LT G  V+MGRKTFESIG+PLP R
Sbjct  4    ESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNR  63

Query  62   RNVVLTRNPNFQAEGVEVVPTLQAGLAggeim-----vigggevYALALPLARRMWLTLV  116
            + +V++R++N++A G  VV+TL  ++A +  +     V GG+E+Y+LALP A+ + L+ V
Sbjct  64   HTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEV  123

Query  117  DTEITEADTFFPEFDPSEW  135
            +  + E+D+FFP ++ +E 
Sbjct  124  HQTF-EGDAFFPMLNETEF  141

189) folA in NC_010694


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 93.3 bits (335),  Expect = 7e-21, Method: Compositional matrix adjust.
 Identities = 57/135 (43%), Positives = 91/135 (68%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRLNIV  62
            I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISRQKG-EAEGVVWVTGIEDALSAAGEV-EELMVIGGGRIYEQMLPRADRLYLTHIDAEV  120
            ISRQ    A G V V+ + +A++ A+E+ +EL V GG+ IY   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  EGDTHFPDYEPDEWQ  135
            EGD+ FP  +  E +
Sbjct  128  EGDAFFPMLNETEFE  142

190) Echvi_2448 in NC_019904


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 93.3 bits (335),  Expect = 7e-21, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 92/127 (73%), Gaps = 2/127 (1%)

Query  13   IIVAKANNNVIGKDNQLIWRLSADLRHFKQQTTGHYIIMGRKTYESMGKPLPNRTSVVIT  72
            ++ A + N VIG++ ++ W+++++ + F++ T G  ++MGRKT+ES+GKPLPNR ++VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  73   RNKQYEVPEGHHVVHSLEKAIAIAKEGGDDKAFIIGGAEIYKQALPLVDEMIITVVDCAP  132
            R+ +Y  + G  VV +L  AIA+A E G++  ++ GGAEIY  ALP  + ++++ V+ + 
Sbjct  70   RQANYR-ATGCVVVSTLSHAIALASELGNE-LYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  133  EGDAYFP  139
            EGDA+FP
Sbjct  128  EGDAFFP  134

191) PputUW4_05157 in NC_019670


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 93.3 bits (335),  Expect = 7e-21, Method: Compositional matrix adjust.
 Identities = 58/141 (42%), Positives = 93/141 (66%), Gaps = 5/141 (3%)

Query  9    LIAALGENRVIGVNNSMPWHLPGDFKYFKETTLGKPIIMGRKTWDSLGRPLPGRLNIVVS  68
            L+AA+G NRVIG   ++PW +PG+ K F+  T GK ++MGRKT +S+G+PLP R  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RQAELQLEGAEVYPSLeaavvraeewareQCVDEVMLIGGAQLYAQGLSHADRLYLTSVA  128
            RQA+ +  G  V ++L  A+  A E +     +E+ + GGA++Y+ +L+HA+ ++L+ V 
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  129  LNPEGDAWFPEFESNQWKLVW  149
               EGDA FP ++  +  LV 
Sbjct  125  QTFEGDAFFPMLNETEFELVS  145

192) folA in NC_017538


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.8 bits (333),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 56/138 (41%), Positives = 95/138 (69%), Gaps = 5/138 (3%)

Query  1    MSASAPAVVFIVAIADNGVIGRDNTMPWHLRSDLQRFKQLTLNKPVVMGRKTFLSIGRPL  60
            M++ +  + ++ A++ N VIG +  +PW + ++ + F++LT  K VVMGRKTF SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PKRTNIVVTRDPAFRAAGAVVATTLDAAYEIALGDALRRGASEIMVIGGAEIFHQWMPRA  120
            P+R  +V++R++ +RA+G VV +TL  A  IAL+  L   ++E+ V GGAEI+   +P+A
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHA--IALASEL---GNELYVAGGAEIYTLALPHA  115

Query  121  TRLEITHVHAEPEGDTFL  138
              + +++VH   EGD+F+
Sbjct  116  HGVFLSEVHQTFEGDAFF  133

193) folA in NC_011386


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.8 bits (333),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 56/138 (41%), Positives = 95/138 (69%), Gaps = 5/138 (3%)

Query  1    MSASAPAVVFIVAIADNGVIGRDNTMPWHLRSDLQRFKQLTLNKPVVMGRKTFLSIGRPL  60
            M++ +  + ++ A++ N VIG +  +PW + ++ + F++LT  K VVMGRKTF SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PKRTNIVVTRDPAFRAAGAVVATTLDAAYEIALGDALRRGASEIMVIGGAEIFHQWMPRA  120
            P+R  +V++R++ +RA+G VV +TL  A  IAL+  L   ++E+ V GGAEI+   +P+A
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHA--IALASEL---GNELYVAGGAEIYTLALPHA  115

Query  121  TRLEITHVHAEPEGDTFL  138
              + +++VH   EGD+F+
Sbjct  116  HGVFLSEVHQTFEGDAFF  133

194) folA in NC_015684


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.8 bits (333),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 56/138 (41%), Positives = 95/138 (69%), Gaps = 5/138 (3%)

Query  1    MSASAPAVVFIVAIADNGVIGRDNTMPWHLRSDLQRFKQLTLNKPVVMGRKTFLSIGRPL  60
            M++ +  + ++ A++ N VIG +  +PW + ++ + F++LT  K VVMGRKTF SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PKRTNIVVTRDPAFRAAGAVVATTLDAAYEIALGDALRRGASEIMVIGGAEIFHQWMPRA  120
            P+R  +V++R++ +RA+G VV +TL  A  IAL+  L   ++E+ V GGAEI+   +P+A
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHA--IALASEL---GNELYVAGGAEIYTLALPHA  115

Query  121  TRLEITHVHAEPEGDTFL  138
              + +++VH   EGD+F+
Sbjct  116  HGVFLSEVHQTFEGDAFF  133

195) folA in NC_008702


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.6 bits (332),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 54/132 (41%), Positives = 87/132 (66%), Gaps = 2/132 (1%)

Query  9    FVVAIASNGVIGRNNALPWRLKADLAHFKAVTLGHPIVMGRKTWESLGRPLPGRRNMVVT  68
            +V A+++N VIG    +PW++ ++   F+ +T G  +VMGRKT ES+G+PLP R+ +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  69   RNADYRAIGAEVFATPEAAVNAVAE--GPLFVIGGAQLYKELLPMADRLLITEVLADVEG  126
            R+A+YRA G  V +T   A+   +E    L+V GGA++Y   LP A+ ++++EV    EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  127  DAYFPPFNLDTF  138
            DA+FP +N   F
Sbjct  130  DAFFPMLNETEF  141

196) folA in NC_013971


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.3 bits (331),  Expect = 1e-20, Method: Compositional matrix adjust.
 Identities = 56/135 (42%), Positives = 91/135 (68%), Gaps = 2/135 (1%)

Query  2    ISLIAALAADRVIGMENAMPWHLPADLAWFKKQTLNKPVIMGRRTWESIGRPLPGRLNIV  61
            I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  62   ISRQKGV-AEGVTWVTTIEDALKAAGEV-QELMVIGGGHVYEQLLPQADRLYLTHIDAEV  119
            ISRQ    A G   V+T+ +A+  A+E+ +EL V GG+++Y   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  120  EGDTHFPDYEPDEWQ  134
            EGD+ FP  +  E +
Sbjct  128  EGDAFFPMLNETEFE  142

197) Sde_0351 in NC_007912


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.3 bits (331),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 89/139 (65%), Gaps = 9/139 (6%)

Query  5    IVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIVVT  64
            +V A + N VIG    +PW+I+++ + F+++T G  ++MGRKT++SIGKPLP R T+V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKVHL  124
            RQA+ +A G      V  +L  A+ LA +++ ++ VA     GGA++Y  AL +   V L
Sbjct  70   RQANYRATGCV----VVSTLSHAIALASELGNELYVA-----GGAEIYTLALPHAHGVFL  120

Query  125  TRVHAEIEGDAWFPELDGN  143
            + VH  +EGDA FP L+  
Sbjct  121  SEVHQTFEGDAFFPMLNET  139

198) dhfrIII in NC_018268


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 92.0 bits (330),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 66/163 (41%), Positives = 98/163 (61%), Gaps = 10/163 (6%)

Query  5    LIVAMAQNRVIGRNNNLPWYLPGDLKYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVIS  64
            L+ AM+ NRVIG   N+PW +PG+ K F++ T GK ++MGRKT +SIG+PLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RNEKWQAPVGttaattlkaalkkaeaqaelDGIKEVMVIGGGQIYAEALPLVDRIYMTLV  124
            R+ + +A      +T   A    +E        +E+ V GG++IY+ ALP  + ++++ V
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELG------NELYVAGGAEIYTLALPHAHGVFLSEV  123

Query  125  HADVEGDAYFPEVNWEEWNEVGREDFSASDNNPYNYSFVVYQR  167
            H   EGDA+FP +N  E + V+ E + A    PY  S  VY R
Sbjct  124  HQTFEGDAFFPMLNETEFELVSTETIQAV--IPYTHS--VYAR  162

199) folA in NC_012214


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.8 bits (329),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 57/135 (43%), Positives = 90/135 (67%), Gaps = 2/135 (1%)

Query  2    ISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRLNIV  61
            I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  62   ISRQKGV-AEGVTWVTTIEDALKAAGEV-QELMVIGGGRIYEQLLPQADRLYLTHIDAEV  119
            ISRQ    A G   V+T+ +A+  A+E+ +EL V GG+ IY   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  120  EGDTHFPDYEPDEWQ  134
            EGD+ FP  +  E +
Sbjct  128  EGDAFFPMLNETEFE  142

200) Caka_1328 in NC_014008


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.8 bits (329),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 54/129 (42%), Positives = 89/129 (69%), Gaps = 3/129 (2%)

Query  7    IAAMAENRVIGNNGDIPWHLPEDFQWFKQTTMGGILVMGRKTYDSIGRPLPGRDTFVFSR  66
            +AAM+ NRVIGN  +IPW +P + + F++ T G ++VMGRKT++SIG+PLP R+T+V+SR
Sbjct  11   VAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR  70

Query  67   TPR-EIKGVHSFTDLEMLEHFKTD--KTIWIAGGAEIYRQLLPHCSDLYLTRVHRSCEGD  123
             +     G    + L     + ++  + + +AGGAEIY   LPH  +++L+ VH++ EGD
Sbjct  71   QANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGD  130

Query  124  ALFPPFEDS  132
            A+FP ++++
Sbjct  131  AFFPMLNET  139

201) NGO1694 in NC_002946


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.5 bits (328),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 61/137 (45%), Positives = 94/137 (69%), Gaps = 2/137 (1%)

Query  2    LKITIIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I ++AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYCAAGAETVASLEVALALCAG-AEEAVIMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G   V++L  A+AL +  ++E  + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPEIDRTHW  137
             + EGDAFFP ++ T+ 
Sbjct  125  QTFEGDAFFPMLNETEF  141

202) folA in NC_013961


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.5 bits (328),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 56/135 (42%), Positives = 91/135 (68%), Gaps = 2/135 (1%)

Query  15   ISLIAALAADRVIGMENAMPWHLPADLAWFKKQTLNKPVIMGRRTWESIGRPLPGRLNIV  74
            I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  75   ISRQKGV-AEGVTWVTTIEDALKAAGEV-QELMVIGGGHVYEQLLPQADRLYLTHIDAEV  132
            ISRQ    A G   V+T+ +A+  A+E+ +EL V GG+++Y   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  133  EGDTHFPDYEPDEWQ  147
            EGD+ FP  +  E +
Sbjct  128  EGDAFFPMLNETEFE  142

203) folA in NC_017390


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.5 bits (328),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 57/138 (42%), Positives = 91/138 (66%), Gaps = 2/138 (1%)

Query  12   DMMISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRL  71
             + I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R 
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRH  64

Query  72   NIVISRQKGV-AEGVTWVTTIEDALKAAGEV-QELMVIGGGRIYEQLLPQADRLYLTHID  129
             +VISRQ    A G   V+T+ +A+  A+E+ +EL V GG+ IY   LP+A+ ++L++++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  130  AEVEGDTHFPDYEPDEWQ  147
               EGD+ FP  +  E +
Sbjct  125  QTFEGDAFFPMLNETEFE  142

204) ambt_15520 in NC_015554


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.0 bits (326),  Expect = 3e-20, Method: Compositional matrix adjust.
 Identities = 53/128 (42%), Positives = 86/128 (68%), Gaps = 3/128 (2%)

Query  1    MIAAMANNRVIGADNDMPWHLPADLKHFKQVTMGKPVIMGRKTYESIGRALPGRPNIVIT  60
            ++AAM+ NRVIG + ++PW +P++ K F+++T GK V+MGRKT+ESIG++LP R  +VI+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  61   TNSAYSLPDASVVSSPEAAIEYASALESHPDEVMIIGGGTIYQAFLDKADTLHLTFINLA  120
             ++ Y   +  VVS+   AI  AS L    +E+ + GG+ IY   L  A+ + L+ ++ +
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELG---NELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  VEGDTQFP  128
             EGD+ FP
Sbjct  127  FEGDAFFP  134

205) folA in NC_017445


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 91.0 bits (326),  Expect = 4e-20, Method: Compositional matrix adjust.
 Identities = 57/135 (43%), Positives = 90/135 (67%), Gaps = 2/135 (1%)

Query  14   ISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRLNIV  73
            I L+AA++A+RVIG    +PW +P++   F++ T  K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  74   ISRQKGV-AEGVTWVTTIEDALKAAGEV-QELMVIGGGRIYEQLLPQADRLYLTHIDAEV  131
            ISRQ    A G   V+T+ +A+  A+E+ +EL V GG+ IY   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  132  EGDTHFPDYEPDEWQ  146
            EGD+ FP  +  E +
Sbjct  128  EGDAFFPMLNETEFE  142

206) Shewmr7_3120 in NC_008322


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 90.7 bits (325),  Expect = 4e-20, Method: Compositional matrix adjust.
 Identities = 56/134 (42%), Positives = 93/134 (70%), Gaps = 3/134 (2%)

Query  14   VIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLQIEG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+ +  G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFEDA-KLAAGDCEELVVIgggqlyqqllPQADTLYLTQINLEVEGDTFFPAWDS  132
               V+++ +A  LA+   +EL V GG+++Y   LP+A+ ++L++++   EGD+FFP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  DKWQ--ETESVTSI  144
               +   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

207) SPISAL_08210 in NC_021291


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 90.5 bits (324),  Expect = 5e-20, Method: Compositional matrix adjust.
 Identities = 57/141 (41%), Positives = 96/141 (69%), Gaps = 1/141 (0%)

Query  1    MDTHKPRITFVVAMADNRVIGRDNDLPWRLPDDMRHFVALTRGKPIVMGRKNYASIGRPL  60
            M+++  RI +V AM+ NRVIG + ++PW++P++ + F  LT GK +VMGRK + SIG+PL
Sbjct  1    MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL  60

Query  61   PKRLNIVMTRDPNWQAEGCEVVHSaeaalaaagdaeeia-iiggadiYRAFLPMADRIEL  119
            P+R  +V++R++N +A GC VV +   A+A A++  +   + GGA+IY   LP A+ + L
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  120  TRVRTEIAGDTFFPVFEGPAW  140
            + V+  + GD+FFP+++    
Sbjct  121  SEVHQTFEGDAFFPMLNETEF  141

208) RPE_2177 in NC_008435


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 90.5 bits (324),  Expect = 5e-20, Method: Compositional matrix adjust.
 Identities = 56/138 (41%), Positives = 92/138 (67%), Gaps = 5/138 (3%)

Query  6    LIVAVADNGVIGHRGAMPWRLKSDLQRFKALTLGKPVVMGRKTFASIGRPLPGRTNIVVS  65
            L+ A++ N VIG+   +PW++ ++ + F+ LT GK VVMGRKTF SIG+PLP R  +V+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  66   RDDSLKLPGAIVTTSFAEARRIAQGDALRRFATEIAVIGGAEIYQQFLGEADRIELTEVH  125
            R+ + +  G +V +++++A  IA +  L   + E+ V GGAEIY   L +A+ + L+EVH
Sbjct  70   RQANYRATGCVVVSTLSHA--IALASEL---GNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  126  ACPEGDTVFAPLDAAQWQ  143
               EGD+ F+ L+ ++ +
Sbjct  125  QTFEGDAFFPMLNETEFE  142

209) folA in NC_009832


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 90.5 bits (324),  Expect = 5e-20, Method: Compositional matrix adjust.
 Identities = 55/135 (41%), Positives = 92/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNIV  62
            I L+AA++A+RVIG    +PW +P++   F+R T  K V+MGRKTFESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LSSRAG-TDAGVTWATSIDEALAAAGDV-EEVMVIGGGRIYSQFLARANRMYLTHIDAEV  120
            +S +A    +G    +++ +A+A A+++ +E+ V GG+ IY+  L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  GGDAHFPDYEPDEWE  135
             GDA FP  +  E E
Sbjct  128  EGDAFFPMLNETEFE  142

210) folA in NC_008358


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 90.5 bits (324),  Expect = 6e-20, Method: Compositional matrix adjust.
 Identities = 56/139 (41%), Positives = 94/139 (68%), Gaps = 6/139 (4%)

Query  4    EVKLCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGR  63
             V++ L+ A + NR+IG +  +PW++ ++  +F+  T G  V+MGRKT ES+ K PLP R
Sbjct  5    SVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGK-PLPNR  63

Query  64   ENIVLTRDWDYDAAEARVYSSFPaamnaaraiaaREGKDEAFVIGGAEIYALALPFADRI  123
            + +V++R+ +Y A+   V S+++ A+  A      E  +E +V GGAEIY+LALP A+ +
Sbjct  64   HTLVISRQANYRATGCVVVSTLSHAIALA-----SELGNELYVAGGAEIYTLALPHAHGV  118

Query  124  YLTEVDAEIEGDTLFPELD  142
            +L+EV+  +EGD++FP L+
Sbjct  119  FLSEVHQTFEGDAFFPMLN  137

211) Shewmr4_0900 in NC_008321


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.9 bits (322),  Expect = 7e-20, Method: Compositional matrix adjust.
 Identities = 56/134 (42%), Positives = 92/134 (69%), Gaps = 3/134 (2%)

Query  14   VIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLQIDG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+ +  G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFEDA-KLAAGECEELVVIgggqlyqqllPQADTLYLTQISLDVEGDTFFPAWDS  132
               V+++ +A  LA+   +EL V GG+++Y   LP+A+ ++L+++    EGD+FFP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  DKWQ--ETESVTGI  144
               +   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

212) Thivi_0961 in NC_018012


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.9 bits (322),  Expect = 8e-20, Method: Compositional matrix adjust.
 Identities = 52/127 (41%), Positives = 86/127 (68%), Gaps = 1/127 (0%)

Query  31   VIGRDNALPWRLPADLAHFKRLTLDKPIVMGRRTWESLPGLLPRRRHIVLSRNPDFRADG  90
            VIG +  +PW++P++   F+RLT +K +VMGR+T ES+   LP R+ +V+SR++++RA G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  91   CTvvas-ldaavavaggvPELMIVGGAALYTEALPRASRLYLTLVHVRVDGDALFPHWDP  149
            C VV++  +A    +    EL + GGA +YT ALP+A  ++L+ VH   +GDA+FP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  150  TQWHEVT  156
            T+ + V+
Sbjct  139  TEFELVS  145

213) folA in NC_014147


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.7 bits (321),  Expect = 9e-20, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 96/142 (68%), Gaps = 8/142 (5%)

Query  2    ENIQLVHVVAMSQNRAIGKDNQLLWHIPDDLQHFKRITHGGVIVMGRKTFESLPNLLPNR  61
            E++++  V AM+ NR IG++ ++ W IP++ + F+R+T+G V+VMGRKTFES+ + LPNR
Sbjct  4    ESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNR  63

Query  62   THIVITRQPIGY--EGAVTAHSLQDAILLAKAYAHAKQQNKIFIIGGGEIYHQSLEMADV  119
              +VI+RQ+  Y   G V   +L +AI LA   +     N +++ GG+EIY  +L  A+ 
Sbjct  64   HTLVISRQA-NYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHG  117

Query  120  LEITEVDTVIEGDTFYPDIDEK  141
            + ++EV+  +EGD+F+P ++E 
Sbjct  118  VFLSEVHQTFEGDAFFPMLNET  139

214) folA in NC_013892


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.1 bits (319),  Expect = 1e-19, Method: Compositional matrix adjust.
 Identities = 60/142 (43%), Positives = 91/142 (65%), Gaps = 2/142 (1%)

Query  1    MNISLIAAMAMDRVIGMENAMPWTLPGDLAWFKRNTLGKSVVMGRVTYESIGRPLPGRLN  60
            + I L+AAM+ +RVIG    +PW +PG+   F+R T GK VVMGR T+ESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISSQPA-RDDSVTWVRTIEEALAAAGDV-DEIMVMGGGKIYEQFIPLAHRMYLTHIDA  118
            +VIS Q+  R  +   V T+ +A+A A+++ +E+ V GG+ IY   +P AH ++L++++ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  119  EVIGDTHFPDYAPDEWNSVFTE  140
               GD+ FP     E + V TE
Sbjct  126  TFEGDAFFPMLNETEFELVSTE  147

215) Shewana3_3214 in NC_008577


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.1 bits (319),  Expect = 1e-19, Method: Compositional matrix adjust.
 Identities = 56/134 (42%), Positives = 93/134 (70%), Gaps = 3/134 (2%)

Query  14   VIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIVISRQADLQIEG  73
            VIG++ ++PW +P + + F+ +T GK VVMGRKTFESIG+PLP RH +VISRQA+ +  G
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISRQANYRATG  78

Query  74   VTCVTSFEDA-KLAAGDCEELVVIgggqlyqqllPQADRLYLTQINLEVEGDTFFPAWDS  132
               V+++ +A  LA+   +EL V GG+++Y   LP+A+ ++L++++   EGD+FFP  + 
Sbjct  79   CVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFPMLNE  138

Query  133  DKWQ--ETESLTSI  144
               +   TE++ ++
Sbjct  139  TEFELVSTETIQAV  152

216) folA in NC_014306


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.1 bits (319),  Expect = 1e-19, Method: Compositional matrix adjust.
 Identities = 55/135 (41%), Positives = 92/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAAMAADRVIGMDNAMPWHLPADLAWFKRQTLDKPVIMGRRTWESIGRPLPGRLNIV  62
            I L+AAM+A+RVIG +  +PW +P++   F+R T +K V+MGR+T ESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   ISSQPG-DAEGVSWVTSIDEALQAAGEV-DEVMVIGGGRIYEQLLPRADRLYLTHIDAEV  120
            IS Q+   A G   V+++ +A+  A+E+ +E+ V GG+ IY   LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  VGDTTFPDFEPEEWQ  135
             GD+ FP ++  E +
Sbjct  128  EGDAFFPMLNETEFE  142

217) Tmz1t_1591 in NC_011662


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 89.1 bits (319),  Expect = 1e-19, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 89/134 (67%), Gaps = 1/134 (0%)

Query  6    IVLIAAVARNGTIGRDNELPWRLKADLQHFRALTLGHPILMGRKTWQSLGRPLPGRRNLV  65
            I L+AA++ N  IG + ++PW++ ++ + FR LT G  ++MGRKT +S+G+PLP R+ LV
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   VSRTPDYRAEG-aecfadpaaaiaaageaQTLFVIGGAQLYAQLLPLADRLELTEVKADV  124
            +SR ++YRA G     + + A   A+  ++ L+V GGA++Y+  LP A+ + L+EV    
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  125  EGDAHFPAVDPARF  138
            EGDA FP ++ + F
Sbjct  128  EGDAFFPMLNETEF  141

218) folA in NC_020796


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.6 bits (317),  Expect = 2e-19, Method: Compositional matrix adjust.
 Identities = 54/133 (41%), Positives = 88/133 (67%), Gaps = 2/133 (1%)

Query  5    LIAALSADRVIGLDNAMPWHLPADLAWFKRNTLAKPVIMGRKTYESIGRPLPGRHNIVIS  64
            L+AA++A+RVIG +  +PW +P++   F+R T +K V+MGRKT+ESIG+PLP RH +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RRAGCDDR--VTWVTTPqaaleaaaeaqeVMIIGGGSIYSQFLPQASRLYLTHVDADVAG  122
            R+A       V   T ++A   A+  ++E+ + GG+ IY+  LP+A  ++L++V+    G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTYFPDYAPDEWQ  135
            D++FP     E +
Sbjct  130  DAFFPMLNETEFE  142

219) folA in NC_013508


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.6 bits (317),  Expect = 2e-19, Method: Compositional matrix adjust.
 Identities = 54/133 (41%), Positives = 88/133 (67%), Gaps = 2/133 (1%)

Query  5    LIAALSADRVIGLDNAMPWHLPADLAWFKRNTLAKPVIMGRKTYESIGRPLPGRHNIVIS  64
            L+AA++A+RVIG +  +PW +P++   F+R T +K V+MGRKT+ESIG+PLP RH +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RRAGCDDR--VTWVTTPqaaleaaaeaqeVMIIGGGSIYSQFLPQASRLYLTHVDADVAG  122
            R+A       V   T ++A   A+  ++E+ + GG+ IY+  LP+A  ++L++V+    G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTYFPDYAPDEWQ  135
            D++FP     E +
Sbjct  130  DAFFPMLNETEFE  142

220) ETAF_0543 in NC_017309


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.6 bits (317),  Expect = 2e-19, Method: Compositional matrix adjust.
 Identities = 54/133 (41%), Positives = 88/133 (67%), Gaps = 2/133 (1%)

Query  5    LIAALSADRVIGLDNAMPWHLPADLAWFKRNTLAKPVIMGRKTYESIGRPLPGRHNIVIS  64
            L+AA++A+RVIG +  +PW +P++   F+R T +K V+MGRKT+ESIG+PLP RH +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RRAGCDDR--VTWVTTPqaaleaaaeaqeVMIIGGGSIYSQFLPQASRLYLTHVDADVAG  122
            R+A       V   T ++A   A+  ++E+ + GG+ IY+  LP+A  ++L++V+    G
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  123  DTYFPDYAPDEWQ  135
            D++FP     E +
Sbjct  130  DAFFPMLNETEFE  142

221) PADK2_01755 in NC_018080


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.4 bits (316),  Expect = 2e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAALALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

222) amb1326 in NC_007626


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/128 (45%), Positives = 89/128 (70%), Gaps = 3/128 (2%)

Query  19   LIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIVVT  78
            L+ A++AN VIG++  +PW IP + K F+  T GK V+MGRKT ESIG+PLP+R  +V++
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  79   RQTGWRAEGAHTAHSldealalaarlapeaaelMVIGGNSLFAEALPGARRLYLTEIARA  138
            RQ+  RA G     +L +A+ALA+ L+ E     V GG  +++ ALP A+ ++L+E+ ++
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELY---VAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  139  YEGDTMFP  146
            +EGD+ FP
Sbjct  127  FEGDAFFP  134

223) G655_01775 in NC_020912


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

224) folA in NC_017548


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

225) folA in NC_017549


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

226) folA in NC_002516


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

227) M062_01750 in NC_021577


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

228) folA in NC_008463


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 88.1 bits (315),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 90/142 (64%), Gaps = 5/142 (3%)

Query  7    MIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVS  66
            ++AA+G NR IG +  +PW++P++ K F+ +T GK V+MGRKT +S+G+PLP R  LV+S
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  67   RQAGLALEGAEVFasldaalaraeawaqaedadelMLIGGAQLYAEALPRAARLYLTRVG  126
            RQA     G  V      +         +E ++EL + GGA++Y+ ALP+A  ++L+ V 
Sbjct  70   RQANYRATGCVV-----VSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  127  LAPEGDAFFPEIDGAAWRLASS  148
             + EGDAFFP ++ +   L S+
Sbjct  125  QTFEGDAFFPMLNETEFELVST  146

229) folA in NC_006087


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.8 bits (314),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 54/133 (41%), Positives = 84/133 (64%), Gaps = 5/133 (3%)

Query  3    IALIWAQARNRVIGAGGTMPWRLPEDLRHFRELTGGEPVVMGRRTWESLPDRFRPLPGRR  62
            I L+ A + NRVIG G  +PW++P + + FR LT G  VVMGR+T ES+    +PLP R+
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRH  64

Query  63   NIVVTRQEGWNAPGAEVAHALPGALSAASD--DTVWVIGGGELYRQALPLADRVEVTEID  120
             +V++RQ    A G  V  +L+ A++ AS+  + + V GG+E+Y  ALP A+ V ++E++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LAVAGDTPAPALG  133
             +  GD+  P L 
Sbjct  125  QTFEGDAFFPMLN  137

230) M943_14275 in NC_021740


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 4e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  9    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  68
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  69   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  123
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  124  LPREAGDALAPVLDET  139
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

231) dfrA in NC_015758


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

232) dfrA in NC_002945


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

233) K60_028580 in NC_020245


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

234) dfrA in NC_016804


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

235) dfrA in NC_008769


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

236) dfrA in NC_012207


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

237) dfrA in NC_015848


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

238) dfrA in NC_019950


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

239) dfrA in NC_019965


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

240) dfrA in NC_019951


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

241) dfrA in NC_019952


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

242) J112_14800 in NC_021054


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

243) J113_19165 in NC_021193


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

244) CCDC5079_2534 in NC_017523


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

245) dfrA in NC_021251


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

246) CCDC5180_2504 in NC_017522


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

247) folA in NC_002755


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

248) dfrA in NC_017524


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

249) J114_14740 in NC_021194


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

250) dfrA in NC_020559


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

251) TBFG_12776 in NC_009565


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

252) dfrA in NC_009525


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

253) RVBD_2763c in NC_018143


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

254) dfrA in NC_000962


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

255) TBHG_02695 in NC_022350


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

256) TBMG_01212 in NC_012943


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  6    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  65
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  120
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPREAGDALAPVLDET  136
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

257) TBSG_01222 in NC_016768


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

258) TBXG_001202 in NC_018078


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

259) MRGA423_17145 in NC_017528


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

260) MT7199_2796 in NC_020089


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

261) dfrA in NC_016934


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 87.3 bits (312),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 92/136 (68%), Gaps = 11/136 (8%)

Query  4    LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV  63
            L+ A +++ VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  64   VLSRQADFMASGAEVVGSLEEALT-----SPETWVIGGGQVYALALPYATRCEVTEVDIG  118
            V+SRQA++ A+G  VV++L +A++     + E  V GG+++Y+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  119  LPREAGDALAPVLDET  134
            +    GDA+ P+L+ET
Sbjct  127  F---EGDAFFPMLNET  139

262) O159_15960 in NC_022438


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 86.0 bits (307),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 55/133 (42%), Positives = 81/133 (61%), Gaps = 5/133 (3%)

Query  3    ITLIWAQARDRVIGAGGAMPWHLPEDLRHFRELTGGEPVVMGRRTWESIPDRFRPLPGRR  62
            I L+ A + +RVIG G  +PW +P + + FR LT G  VVMGR+T ESI    +PLP R+
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRH  64

Query  63   NIVVTRQKGWDAPGAEVAHSLSGALTAAGD--GTAWVIGGGELYRQALPLADRVEVTEID  120
             +V++RQ    A G  V  +LS A++ A++      V GG+E+Y  ALP A+ V ++E++
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LTVAGDTHAPALG  133
             T  GD+  P L 
Sbjct  125  QTFEGDAFFPMLN  137

263) folA in NC_017531


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 85.7 bits (306),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 88/127 (70%), Gaps = 2/127 (1%)

Query  13   ISLIAALAADRIIGMENAMPWDLPADLAWFKRNTLKKPVIMGRLTFESIGRPLPGRLNIV  72
            I L+AA++A+R+IG    +PW +P++   F+R T  K V+MGR TFESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  73   VSSKPG-SAEGVTWVTSLDDAISAAGE-AEEIMVIGGGRIYEQMLARADRLYLTHIDAEV  130
            +S ++   A G   V++L +AI+ A+E ++E+ V GG+ IY   L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  131  EGDTQFP  137
            EGD+ FP
Sbjct  128  EGDAFFP  134

264) folA in NC_013956


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 85.7 bits (306),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 88/127 (70%), Gaps = 2/127 (1%)

Query  13   ISLIAALAADRIIGMENAMPWDLPADLAWFKRNTLKKPVIMGRLTFESIGRPLPGRLNIV  72
            I L+AA++A+R+IG    +PW +P++   F+R T  K V+MGR TFESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  73   VSSKPG-SAEGVTWVTSLDDAISAAGE-AEEIMVIGGGRIYEQMLARADRLYLTHIDAEV  130
            +S ++   A G   V++L +AI+ A+E ++E+ V GG+ IY   L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  131  EGDTQFP  137
            EGD+ FP
Sbjct  128  EGDAFFP  134

265) PAGR_g3518 in NC_017554


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 85.7 bits (306),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 88/127 (70%), Gaps = 2/127 (1%)

Query  13   ISLIAALAADRIIGMENAMPWDLPADLAWFKRNTLKKPVIMGRLTFESIGRPLPGRLNIV  72
            I L+AA++A+R+IG    +PW +P++   F+R T  K V+MGR TFESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  73   VSSKPG-SAEGVTWVTSLDDAISAAGE-AEEIMVIGGGRIYEQMLARADRLYLTHIDAEV  130
            +S ++   A G   V++L +AI+ A+E ++E+ V GG+ IY   L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  131  EGDTQFP  137
            EGD+ FP
Sbjct  128  EGDAFFP  134

266) folA in NC_016816


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 85.7 bits (306),  Expect = 1e-18, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 88/127 (70%), Gaps = 2/127 (1%)

Query  13   ISLIAALAADRIIGMENAMPWDLPADLAWFKRNTLKKPVIMGRLTFESIGRPLPGRLNIV  72
            I L+AA++A+R+IG    +PW +P++   F+R T  K V+MGR TFESIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  73   VSSKPG-SAEGVTWVTSLDDAISAAGE-AEEIMVIGGGRIYEQMLARADRLYLTHIDAEV  130
            +S ++   A G   V++L +AI+ A+E ++E+ V GG+ IY   L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  131  EGDTQFP  137
            EGD+ FP
Sbjct  128  EGDAFFP  134

267) Dsui_1240 in NC_016616


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 85.5 bits (305),  Expect = 2e-18, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 93/136 (69%), Gaps = 5/136 (3%)

Query  18   LIVAVGANRAIGLDNQLLWRLPEDMAYFKATTQGRPVIMGRKTWESLPEKFRPLPGRRNV  77
            L+ A+GANR IG + ++ W++P +   F+  T+G+ V+MGRKT ES+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  78   VVSRNRDYLAPGailahsleealaaagg--geVFVMGGADLYAQALPLARRLYLTEVRDE  135
            V+SR+ +Y A G ++  +L +A+A A+    E++V GGA++Y+ ALP A+ ++L+EV++ 
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  136  PRADAFFPALEADAWE  151
              +DAFFP L+    E
Sbjct  127  FEGDAFFPMLNETEFE  142

268) D781_0673 in NC_020064


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 84.2 bits (300),  Expect = 4e-18, Method: Compositional matrix adjust.
 Identities = 55/135 (41%), Positives = 93/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNIV  62
            I L+AA++A+RVIG    +PW +P++   F+R T  K V+MGRKTFESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LSSRPG-SESGVTWATSLDEALAAAGNveevm-vmgggHIYTQFLPRADRLYLTHIDAEI  120
            +S ++    +G    ++L +A+A A+++ + + V GG++IYT  LP+A+ ++L++++  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  GGDTHFPDYEPDEWE  135
             GD+ FP  +  E E
Sbjct  128  EGDAFFPMLNETEFE  142

269) I917_19365 in NC_021192


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 83.9 bits (299),  Expect = 5e-18, Method: Compositional matrix adjust.
 Identities = 53/127 (42%), Positives = 84/127 (67%), Gaps = 11/127 (8%)

Query  32   VIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFM  91
            VIG G +IPW++P +Q  FR +T G  +VMGR+T +S+    +PLP R+ +V+SRQA++ 
Sbjct  19   VIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTLVISRQANYR  75

Query  92   ASGAEVVGSLEEALT-----SPETWVIGGXXVYALALPYATRCEVTEVDIGLPXEAGDAL  146
            A+G  VV++L +A++     + E  V GG  +Y+LALP A    ++EV+  +    GDA+
Sbjct  76   ATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF---EGDAF  132

Query  147  APVLDET  153
             P+L+ET
Sbjct  133  FPMLNET  139

270) Mycsm_02511 in NC_019966


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.8 bits (295),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 55/136 (41%), Positives = 88/136 (65%), Gaps = 11/136 (8%)

Query  6    LIWAQSTSGVIGRDGGIPWRLPEDQARFKDLTMGHTVVMGRLTWESLPAKVRPLPGRRNV  65
            L+ A +++ VIG +  IPW++P +Q  F+ LT G  VVMGR T ES+    +PLP R+ +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VVTRQAGYPAEGAQVVPSFDDALT-----GDDTWVIGGAQIYALALPIATRCEVTEVEID  120
            V++RQA Y A G  VV+++ +A++     G++  V GGA+IY+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LRRQDTDAVAPVLDES  136
            +   + DA  P+L+E+
Sbjct  127  F---EGDAFFPMLNET  139

271) RPC_3263 in NC_007925


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.8 bits (295),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 51/126 (41%), Positives = 86/126 (69%), Gaps = 5/126 (3%)

Query  2    IQIVLIVAVADNGVIGSAGALPWRLKSDLQRFKQLTLNKPVVMGRKTFASIGRPLPGRTN  61
            ++I L+ A++ N VIG++  +PW++ ++ + F++LT  K VVMGRKTF SIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  62   IVMTRDTGLTLPGAVVTSSFDTAQAIARGDALRRFATEIAVIGGAEVYAQWLAVADRIEL  121
            +V++R++     G VV S++  ++AIA +  L   + E+ V GGAE+Y+  L+ A+ + L
Sbjct  66   LVISRQANYRATGCVVVSTL--SHAIALASEL---GNELYVAGGAEIYTLALPHAHGVFL  120

Query  122  TEVHAS  127
            +EVH +
Sbjct  121  SEVHQT  126

272) folA in NC_014228


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.8 bits (295),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 89/142 (63%), Gaps = 2/142 (1%)

Query  1    MNISLIAAMAMDRVIGMENAMPWTLPGDLAWFKRNTLGKPVVMGRVTYESIGRPLPGRLN  60
            + I L+AAM+ +RVIG    +PW +PG+   F+R T GK VVMGR T+ESIG+PLP R  
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65

Query  61   IVISSQPA-SDDQVTWVNSIEAALAAAGDV-EEIMVMGGGKIYEQFIPLASRMYLTHIDA  118
            +VIS Q+         V+++  A+A A+++ +E+ V GG+ IY   +P A  ++L++++ 
Sbjct  66   LVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQ  125

Query  119  EVIGDTHFPDYEPDEWNSVFTE  140
               GD+ FP  +  E + V TE
Sbjct  126  TFEGDAFFPMLNETEFELVSTE  147

273) dfrA in NC_015576


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 57/136 (42%), Positives = 88/136 (65%), Gaps = 11/136 (8%)

Query  6    LIWAQSTSGVIGRDGGIPWRLPEDQARFKELTLGHRVVMGRLTWESLPAGVRPLPGRANV  65
            L+ A +++ VIG +  IPW++P +Q  F+ LT G  VVMGR T ES+    +PLP R  +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VVSRRSDYRAVGAEVVPTLDAALT-----DAETWVIGGAQIYALALPLADRCEVTEVEID  120
            V+SR+++YRA G  VV+TL  A++     + E  V GGA+IY+LALP A+   ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPRQDEDAVAPVLDES  136
            +   + DA  P+L+E+
Sbjct  127  F---EGDAFFPMLNET  139

274) folA in NC_017941


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 59/147 (41%), Positives = 97/147 (66%), Gaps = 9/147 (6%)

Query  5    TDDSVRFVLVAAVAENRVIGRDGDMPWHLPEDLKHFKATTMGHPVVMGRTTYESIARQID  64
              +SVR+ LVAA++ NRVIG + ++PW +P + K F+  T G  VVMGR T+ESI++   
Sbjct  2    NSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGK---  58

Query  65   GPLPGRRNIVLTSRDLDLPAGAEtvdsvdeavtaaeaaaddMGVETVYVVGGATVYEQFL  124
             PLP R+ +V+ SR+ +  A +     V  +++ A A A ++G E +YV GGA +Y   L
Sbjct  59   -PLPNRHTLVI-SRQANYRATG---CVVVSTLSHAIALASELGNE-LYVAGGAEIYTLAL  112

Query  125  DRASGLILTELDEAYEGDTYFPEWRDT  151
             +A G++L+E+++++EGD++FP   +T
Sbjct  113  PHAHGVFLSEVHQTFEGDAFFPMLNET  139

275) folA in NC_021591


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 55/135 (41%), Positives = 92/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNIV  62
            I L+AA++A+RVIG    +PW +P++   F+R T  K V+MGRKTFESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LSSRPG-SETGVTWATSLDEALAAAGDveevm-vmgggHIYTQFLARADRMYLTHIDAEV  120
            +S ++    TG    ++L +A+A A+++ + + V GG++IYT  L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  GGDTHFPDYEPDEWE  135
             GD+ FP  +  E E
Sbjct  128  EGDAFFPMLNETEFE  142

276) folA in NC_021659


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 55/135 (41%), Positives = 92/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNIV  62
            I L+AA++A+RVIG    +PW +P++   F+R T  K V+MGRKTFESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LSSRPG-SETGVTWATSLDEALAAAGDveevm-vmgggHIYTQFLARADRMYLTHIDAEV  120
            +S ++    TG    ++L +A+A A+++ + + V GG++IYT  L++A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  GGDTHFPDYEPDEWE  135
             GD+ FP  +  E E
Sbjct  128  EGDAFFPMLNETEFE  142

277) M892_08845 in NC_022269


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 100/142 (71%), Gaps = 2/142 (1%)

Query  5    MIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNIVIS  64
            ++AAM+ NR+IG++ ++PW +P++   F+R T GK VVMGRKT+ESIG+PLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RDASLSIEGVTTVTSIEQALeiageveevm-iigggaiYAACLPMANKLYVTHIEAEIEG  123
            R+A+    G   V+++ +A+ +A+E+ + + + GG+ IY+  LP A+ +++++++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTQFPDWGN-EFKETYSEAYQA  144
            D+ FP   + EF    +E+ QA
Sbjct  130  DAFFPMLNETEFELVSTETIQA  151

278) VIBHAR_00805 in NC_009783


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.6 bits (294),  Expect = 1e-17, Method: Compositional matrix adjust.
 Identities = 57/142 (41%), Positives = 100/142 (71%), Gaps = 2/142 (1%)

Query  5    MIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNIVIS  64
            ++AAM+ NR+IG++ ++PW +P++   F+R T GK VVMGRKT+ESIG+PLP R  +VIS
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVIS  69

Query  65   RDASLSIEGVTTVTSIEQALeiageveevm-iigggaiYAACLPMANKLYVTHIEAEIEG  123
            R+A+    G   V+++ +A+ +A+E+ + + + GG+ IY+  LP A+ +++++++  +EG
Sbjct  70   RQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG  129

Query  124  DTQFPDWGN-EFKETYSEAYQA  144
            D+ FP   + EF    +E+ QA
Sbjct  130  DAFFPMLNETEFELVSTETIQA  151

279) Dd586_3577 in NC_013592


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 82.1 bits (292),  Expect = 2e-17, Method: Compositional matrix adjust.
 Identities = 51/127 (41%), Positives = 83/127 (66%), Gaps = 2/127 (1%)

Query  3    ISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRNTFRSIGRPLPGRLNIV  62
            I L+AA++ +RVIG    +PW +P++   F+R T  K V+MGR+TF SIG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   VSSQPG-DDERVTWVTSLDAALAAAGDV-EEVMVIGGGCIYQQMLPQAGRLYLTHIDAEV  120
            +S Q+         V++L  A+A A+++ +E+ V GG+ IY   LP+A  ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  EGDTHFP  127
            EGD+ FP
Sbjct  128  EGDAFFP  134

280) NMBM01240355_0319 in NC_017517


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 81.8 bits (291),  Expect = 2e-17, Method: Compositional matrix adjust.
 Identities = 61/138 (45%), Positives = 93/138 (68%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYCAAGAETVasleaalalcasaeeTV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G   V++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPEIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

281) Hmuk_1491 in NC_013202


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 80.7 bits (287),  Expect = 5e-17, Method: Compositional matrix adjust.
 Identities = 55/137 (41%), Positives = 83/137 (61%), Gaps = 3/137 (2%)

Query  6    VAAVGENGVIGSGDELPWHLPHESRRYRERVADDTVVLGRKTFEMFEE-LPGARQLVLSR  64
            VAA+G N VIG+G ++PW +P E + +R    +  VV+GRKTFE +   LP  + LV+SR
Sbjct  11   VAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR  70

Query  65   SERSFEAETATHAASVDAAIDLARERGDPVLYVLGGAGVYEAFLPRYDRMLLSRVDGEYE  124
             + ++ A      +++  AI LA E G+  LYV GGA +Y   LP+ + ++LS V+  +E
Sbjct  71   -QANYRATGCVVVSTLSHAIALASELGNE-LYVAGGAEIYTLALPHAHGVFLSEVHQTFE  128

Query  125  GDATFPAFDREAWTLVD  141
            GDA FP ++     LV 
Sbjct  129  GDAFFPMLNETEFELVS  145

282) folA in NC_016622


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 80.5 bits (286),  Expect = 5e-17, Method: Compositional matrix adjust.
 Identities = 58/132 (44%), Positives = 84/132 (64%), Gaps = 3/132 (2%)

Query  1    MRISLIVAAAMNDVIGRDGRLPWALPGDLRRFKQLTMGKPVLMGRKTWESLPLHPLPGRD  60
            +RI L+ A + N VIG +  +PW +PG+ + F++LT GK V+MGRKT ES+   PLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  61   NLVVSHQAAVGEHDGARWFSGLGAAIAWAQESGAAELCVIGGAALFRETLPIADCLHLTR  120
             LV+S+QA      G    S L+ AIA A E G  EL V GGA ++  +LP A+ + L+ 
Sbjct  65   TLVISRQANYRA-TGCVVVSTLSHAIALASELG-NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  121  VESAMEGDTLMP  132
            V+ + EGD++ P
Sbjct  123  VHQTFEGDAFFP  134

283) Prede_1560 in NC_019968


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 80.5 bits (286),  Expect = 5e-17, Method: Compositional matrix adjust.
 Identities = 58/142 (41%), Positives = 88/142 (62%), Gaps = 4/142 (2%)

Query  3    ISLVAALAANRAIGFRRQLLWHLPEDLHRFKALTLGHAVVMGRKTFESLPHGALPHRRNI  62
            I LVAA++ANR IG   ++ W +P +   F+ LT G  VVMGRKTFES+   +LP+R+ +
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGK-PLPNRHTL  66

Query  63   VLSRSVR-RLPGCEVYASLEAALA-ACGGENEVMVIGGESLYRQTLPLAHRLYLTHVDAE  120
            V+SR    R  GC V ++L  A+A A    NE+ V GG  +Y  +LP AH ++L++V+ +
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH-Q  125

Query  121  PALADAWFPEIVAADWRIVRRE  142
               +DA FP +  ++  +V  E
Sbjct  126  TFEGDAFFPMLNETEFELVSTE  147

284) MycrhN_5637 in NC_016604


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 80.2 bits (285),  Expect = 7e-17, Method: Compositional matrix adjust.
 Identities = 56/136 (42%), Positives = 84/136 (62%), Gaps = 11/136 (8%)

Query  6    LIWAQSSTGVIGRDGGIPWRLPEDQARFKELTMGRTVVMGRLTWESLPAKVRPLPGRKNV  65
            L+ A ++  VIG +  IPW++P +Q  F+ LT G+ VVMGR T ES+    +PLP R  +
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTL  66

Query  66   VLTRQADYMADGAHVVPLLQD--ALTDDIT---WVIGGEQIYALALPLATRCEVTEVEID  120
            V++RQA+Y A G  VV+ L +  AL+ ++     V GG +IY+LALP A    ++EV+  
Sbjct  67   VISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT  126

Query  121  LPRDDGDVVAPTLDET  136
            +   +GD   P L+ET
Sbjct  127  F---EGDAFFPMLNET  139

285) folA in NC_016906


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 79.7 bits (283),  Expect = 9e-17, Method: Compositional matrix adjust.
 Identities = 51/123 (42%), Positives = 79/123 (65%), Gaps = 7/123 (5%)

Query  16   IGRDNTIPWRVPEDMARFREVTGSHAVVMGRKTWESLPERFRPLPGRRNIVITRSQTYRP  75
            IG +  IPW++P +   FR +T +  VVMGRKT ES+    +PLP R+ +VI+R   YR+
Sbjct  20   IGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG---KPLPNRHTLVISRQANYRA  76

Query  76   EGAEVVHTVTEALQLA---GSDAVVMGGGEIYTAAMDYATHLRVTEIDVLVTGADAFAPV  132
             G  VV T+++A+ LA   G++  V GG+EIYT A+  A  + ++E++    G DAF P+
Sbjct  77   TGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTFEG-DAFFPM  135

Query  133  IDE  135
            ++E
Sbjct  136  LNE  138

286) NGK_2087 in NC_011035


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 79.4 bits (282),  Expect = 1e-16, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 93/138 (68%), Gaps = 2/138 (1%)

Query  16   LKITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRR  75
            ++I ++AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  76   NIVISRQADYCAAGAETVasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  134
             +VISRQA+Y A+G   V++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  135  LSVEGDAFFPEIDRTHWK  152
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

287) folA in NC_020075


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 79.2 bits (281),  Expect = 1e-16, Method: Compositional matrix adjust.
 Identities = 53/128 (42%), Positives = 87/128 (68%), Gaps = 4/128 (3%)

Query  5    LIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLNIVL  64
            L+AA+ +N++IG+   IPW +P + K F+  T  K ++MGRKTFESIG KPL NR  +V+
Sbjct  10   LVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRHTLVI  68

Query  65   SRNLLNNYNGVFVVENIDEALSLIQD-AYEVMVIGGSEIYNVFLPRAQRLYLTYIHNMVE  123
            SR+      G  VV  + +A++L  + + E+ V GG+EIY + LP+A+ ++L+ +H+   
Sbjct  69   SRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQT--  126

Query  124  IDGDTLFP  131
            ++GD++FP
Sbjct  127  FEGDAFFP  134

288) Pfl01_5361 in NC_007492


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 78.9 bits (280),  Expect = 1e-16, Method: Compositional matrix adjust.
 Identities = 60/149 (41%), Positives = 98/149 (66%), Gaps = 5/149 (3%)

Query  2    TKSLPLSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPG  61
            + S+ + L+AA+G NRVIG + ++PW +PG+ K F+  T GK ++MGRKT +S+G+PLP 
Sbjct  3    SESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPN  62

Query  62   RLNIVVSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMliggaqlyaqglaqaDR  121
            R  +V+SRQA     G  V ++L  A+  A E +     +EL + GGA++Y+ +L++A+ 
Sbjct  63   RHTLVISRQANYRATGCVVVSTLSHAIALASELG-----NELYVAGGAEIYTLALPHAHG  117

Query  122  LYLTRVALSPEGDAWFPEFDLNQWKLVSN  150
            ++L+ V  + EGDA FP ++  +  LVS 
Sbjct  118  VFLSEVHQTFEGDAFFPMLNETEFELVST  146

289) folA in NC_020211


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 78.9 bits (280),  Expect = 2e-16, Method: Compositional matrix adjust.
 Identities = 57/135 (43%), Positives = 92/135 (69%), Gaps = 2/135 (1%)

Query  3    ISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNIV  62
            I L+AA++A+RVIG    +PW +P++   F+R T  K V+MGRKTFESIG+PLP RH +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   LSSRPG-SEAGVTWVTSLDealaaageveevm-vigggRIYTQLLPRADRLYLTHIDAEV  120
            +S ++    +G   V++L +A+A A+E+ + + V GG+ IYT  LP+A+ ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  GGDTHFPDYEPDEWE  135
             GD+ FP  +  E E
Sbjct  128  EGDAFFPMLNETEFE  142

290) folA in NC_012912


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 78.4 bits (278),  Expect = 2e-16, Method: Compositional matrix adjust.
 Identities = 51/127 (41%), Positives = 84/127 (67%), Gaps = 2/127 (1%)

Query  3    ISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRNTFRAIGRPLPGRLNIV  62
            I L+AA++ +RVIG    +PW +P++   F+R T  K V+MGR+TF +IG+PLP R  +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  63   VSSQPG-DDERVTWVTSlaaalaaaSDV-DEVMVIGGGSIYQQMLPQAGRLYLTHIDAEV  120
            +S Q+         V++L+ A+A AS++ +E+ V GG+ IY   LP+A  ++L++++   
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  121  EGDTHFP  127
            EGD+ FP
Sbjct  128  EGDAFFP  134

291) folA in NC_017512


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.3 bits (270),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

292) NMA2179 in NC_003116


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.3 bits (270),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

293) NMBB_0341 in NC_017505


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

294) NMBH4476_0303 in NC_017516


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

295) NMBM01240149_1775 in NC_017514


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

296) folA in NC_017515


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

297) folA in NC_003112


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

298) folA in NC_017518


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

299) Swit_3786 in NC_009511


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 76.0 bits (269),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 54/132 (41%), Positives = 89/132 (68%), Gaps = 2/132 (1%)

Query  6    IVFVLARARNGVIGRDGDLPWRIPADLRHFKALTQGAPMLMGRKTFESLPGLLPGRRHIV  65
            I +V A + N VIG + ++PW+IP++ + F+ LT+G  ++MGRKTFES+   LP R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  66   LTRDRDWRAEGAEVTHsvdaavaladadrls--vvGGAEIYALLLPRADRIELTEVDDAP  123
            ++R+ + RA G  V  ++  A+ALA        V GGAEIY+L LP+A+ + L+EV+++ 
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  124  EGDTVVPAFDPA  135
            EGD+  P ++ +
Sbjct  128  EGDAFFPMLNET  139

300) folA in NC_013016


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 75.7 bits (268),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/138 (44%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcasaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPEIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

301) folA in NC_014752


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 75.7 bits (268),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/142 (43%), Positives = 94/142 (67%), Gaps = 2/142 (1%)

Query  12   GGNMLKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPL  71
             ++ ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPL
Sbjct  2    NSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPL  60

Query  72   PGRRNIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRI  130
            P R+ +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ +
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  131  TEVDLSVEGDAFFPEIDRTHWK  152
            +EV+ + EGDAFFP ++ T+  
Sbjct  121  SEVHQTFEGDAFFPMLNETEFE  142

302) folA in NC_010120


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 75.7 bits (268),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 60/142 (43%), Positives = 94/142 (67%), Gaps = 2/142 (1%)

Query  32   GGNMLKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPL  91
             ++ ++I L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPL
Sbjct  2    NSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPL  60

Query  92   PGRRNIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRI  150
            P R+ +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ +
Sbjct  61   PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL  120

Query  151  TEVDLSVEGDAFFPEIDRTHWK  172
            +EV+ + EGDAFFP ++ T+  
Sbjct  121  SEVHQTFEGDAFFPMLNETEFE  142

303) NMBG2136_1790 in NC_017513


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 75.2 bits (266),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 59/138 (43%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKLTLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            +++ L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

304) folA in NC_008767


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 75.0 bits (265),  Expect = 3e-15, Method: Compositional matrix adjust.
 Identities = 59/138 (43%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKLTLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLHVKPLPGRR  61
            +++ L+AA + N  IG G  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESI-GKPLPNRH  64

Query  62   NIVISRQADYcaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

305) folA in NC_016617


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 74.4 bits (263),  Expect = 3e-15, Method: Compositional matrix adjust.
 Identities = 56/135 (42%), Positives = 81/135 (60%), Gaps = 3/135 (2%)

Query  1    MRISLVVAAARNGVIGRDGTLPWSLPGDLKRFRELTMGKPVLMGRRTWESLPCKPLPGRD  60
            +RI LV A + N VIG +  +PW +PG+ K FR LT GK V+MGR+T ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  61   NLVVSRSVPPGERDGARWFAGLNAALDWCRGHGVPDVAVIGGAELFRETLPLADIVHLTR  120
             LV+SR  +     G    + L+ A+      G  ++ V GGAE++  +LP A+ V L+ 
Sbjct  65   TLVISRQ-ANYRATGCVVVSTLSHAIALASELG-NELYVAGGAEIYTLALPHAHGVFLSE  122

Query  121  VERDVEGDTVMPPLG  135
            V++  EGD+  P L 
Sbjct  123  VHQTFEGDAFFPMLN  137

306) folA in NC_017501


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 73.4 bits (259),  Expect = 8e-15, Method: Compositional matrix adjust.
 Identities = 59/138 (43%), Positives = 92/138 (67%), Gaps = 2/138 (1%)

Query  2    LKITLIAACAENLCIGADNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRR  61
            ++I L+AA + N  IG +  +PW IP +  +F+  T GK V+MGRKT ES+  KPLP R+
Sbjct  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIG-KPLPNRH  64

Query  62   NIVISRQADYYaagaetaasleaalalcagaeeaV-IMGGAQIYGQAMPLATDLRITEVD  120
             +VISRQA+Y A+G    ++L  A+AL +   + + + GGA+IY  A+P A ++ ++EV+
Sbjct  65   TLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124

Query  121  LSVEGDAFFPAIDRTHWK  138
             + EGDAFFP ++ T+  
Sbjct  125  QTFEGDAFFPMLNETEFE  142

307) Saro_3262 in NC_007794


> EU780013|11|G5|192822647|ACF06156.1|Klebsiella_pneumoniae_12836|+|8532..9029|dfrA12|-|dihydrofolate 
reductase
Length=165

 Score = 71.8 bits (253),  Expect = 2e-14, Method: Compositional matrix adjust.
 Identities = 57/140 (41%), Positives = 89/140 (64%), Gaps = 3/140 (2%)

Query  12   LFLIYARADNGVIGRDNALPWRLPADLRRFKALTLGKPMIMGRRTFDSLPGLLPGRRHVV  71
            ++L+ A + N VIG +  +PW++P++ + F+ LT GK ++MGR+TF+S+   LP R+ +V
Sbjct  8    IYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLV  67

Query  72   LTRDSGWaapgaetattpeaalalagp--geIAVIGGAEAYRLFMPLADRVELTEVHGDY  129
            ++R++   A G    +T   A+ALA+    E+ V GGAE Y L +P A+ V L+EVH  +
Sbjct  68   ISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVHQTF  127

Query  130  EGDTTMPPLG-TEWEEVMRE  148
            EGD+  P L  TE E V  E
Sbjct  128  EGDAFFPMLNETEFELVSTE  147