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Homologs of msrSA gene of NC_007168_R3

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) msrSA
( YP_254220.1 )

erythromycin resistance protein

NC_007168
(Staphylococcus haemolyticus JCSC1435)

0.0

100

2) MS7_0047
( YP_005756514.1 )

AAA ATPase

NC_017351
(Staphylococcus aureus 11819-97)

0.0

3) USA300HOU_pUSA300HOUMR0028
( YP_001569068.1 )

macrolide transporter

NC_010063
(Staphylococcus aureus TCH1516)

0.0

4) msrA
( YP_001700102.1 )

erythromycin resistance ATP-binding protein

NC_010382
(Lysinibacillus sphaericus C3-41)

2e-84

5) OB0699
( NP_691620.1 )

erythromycin resistance protein

NC_004193
(Oceanobacillus iheyensis HTE831)

2e-83

6) EFAU004_02669
( YP_005355867.1 )

ABC transporter ATP-binding protein

NC_017022
(Enterococcus faecium Aus0004)

4e-81

7) HMPREF0351_12617
( YP_006377223.1 )

ABC superfamily ATP binding cassette transporter, ABC protein

NC_017960
(Enterococcus faecium DO)

4e-81

8) M7W_2629
( YP_007395284.1 )

ATPase component of ABC transporter with duplicated ATPase

NC_020207
(Enterococcus faecium NRRL B-2354)

4e-81

9) EFAU085_02754
( YP_008396274.1 )

ABC transporter, ATP-binding protein

NC_021994
(Enterococcus faecium AUS0085)

4e-80

10) ECBG_00224
( YP_007752095.1 )

hypothetical protein

NC_020995
(Enterococcus casseliflavus EC20)

8e-80

11) msrA
( YP_005708258.1 )

ABC superfamily ATP binding cassette transporter, ABC protein

NC_017316
(Enterococcus faecalis OG1RF)

5e-68

12) EF1413
( NP_815134.1 )

msrC protein

NC_004668
(Enterococcus faecalis V583)

1e-67

13) EFD32_1226
( YP_006537591.1 )

ABCF_EF-3 Elongation factor 3 family protein

NC_018221
(Enterococcus faecalis D32)

8e-68

14) EFS1_1238
( YP_007153030.1 )

putative Macrolide resistance protein, ABC transporter like domain

NC_019770
(Enterococcus faecalis Symbioflor 1)

1e-67

• Sequence Alignments

1) msrSA in NC_007168


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  700 bits (2649),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 488/488 (100%), Positives = 488/488 (100%), Gaps = 0/488 (0%)

Query  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIggngtgkttllnMIAQKTKPESG  60
            MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120
            TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120

Query  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180
            SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  181  FKGNYTqyqnqyeqeqleqqrqyeqyISEKQRLSQASKAKRnqaqqmaqasskqknksIA  240
            FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA
Sbjct  181  FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA  240

Query  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300
            PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII
Sbjct  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300

Query  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360
            AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA
Sbjct  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360

Query  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420
            YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL
Sbjct  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420

Query  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480
            AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT
Sbjct  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480

Query  481  GQSIHDIT  488
            GQSIHDIT
Sbjct  481  GQSIHDIT  488

2) MS7_0047 in NC_017351


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  699 bits (2643),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 487/488 (99%), Positives = 488/488 (100%), Gaps = 0/488 (0%)

Query  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIggngtgkttllnMIAQKTKPESG  60
            MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120
            TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120

Query  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180
            SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  181  FKGNYTqyqnqyeqeqleqqrqyeqyISEKQRLSQASKAKRnqaqqmaqasskqknksIA  240
            FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA
Sbjct  181  FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA  240

Query  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300
            PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII
Sbjct  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300

Query  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360
            AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA
Sbjct  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360

Query  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420
            YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL
Sbjct  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420

Query  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480
            AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT
Sbjct  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480

Query  481  GQSLHDIT  488
            GQS+HDIT
Sbjct  481  GQSIHDIT  488

3) USA300HOU_pUSA300HOUMR0028 in NC_010063


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  699 bits (2643),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 487/488 (99%), Positives = 488/488 (100%), Gaps = 0/488 (0%)

Query  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIggngtgkttllnMIAQKTKPESG  60
            MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120
            TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120

Query  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180
            SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  181  FKGNYTqyqnqyeqeqleqqrqyeqyISEKQRLSQASKAKRnqaqqmaqasskqknksIA  240
            FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA
Sbjct  181  FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA  240

Query  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300
            PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII
Sbjct  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300

Query  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360
            AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA
Sbjct  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360

Query  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420
            YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL
Sbjct  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSL  420

Query  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480
            AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT
Sbjct  421  AVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELT  480

Query  481  GQSLHDIT  488
            GQS+HDIT
Sbjct  481  GQSIHDIT  488

4) msrA in NC_010382


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  306 bits (1147),  Expect = 2e-84, Method: Compositional matrix adjust.
 Identities = 187/458 (41%), Positives = 319/458 (70%), Gaps = 11/458 (2%)

Query  21   LNIEKLAIHQFDRIGIVGKNGAGKSTLMKILASKIQPTSGIVKSHVHFGYFEQMEAPMLV  80
            LNI  L   QF++I+++G NG+GK+TL++++A K +P SG V +  ++ YFEQ++  M V
Sbjct  21   LNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQYFEQLN--MDV  78

Query  81   EAE-----GQLLGKLAIP-SNSEGLSGGEQTRLKLAQLFSYYKEALLIDEPTTHLDQEGI  134
            E +     G L++ L IP   ++++SGGE+++ KLA+++S Y   LL+DEPT HLD+ G 
Sbjct  79   ENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNYSPILLLDEPTNHLDKIGK  138

Query  135  SFLVDELRYYYGALVLISHDRAVLDELVTTIWEI-DGGTVNIYSGNYSNYAWQKQLERDQ  193
             +L + L+YYYG+L+++SHDRA++D++  TIW+I ++GT+ ++ GNY++Y  Q + E+ +
Sbjct  139  DYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRVFKGNYTQYQNQYEQEQLE  198

Query  194  QRQAHDLYLKERSRLEKSAEDKMKKAEKITQAGNMSKREAHAKPNLTFMTKSKGTSQKNV  253
            Q++  + Y+ E+ RL +++  K ++A++++QA++  K  + A   L+  +K KGT +K  
Sbjct  199  QQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIAPDRLS-ASKQKGTVEKAA  257

Query  254  QRAAKAIEQRIEKLQKVDAVQVDRKIVFRQSKALELHNKFPIMADQFTLHVPGKALLEEV  313
            Q+ AK IE+R+E L+ V+  Q  + + F Q+K  ++HN++PI+A+++TL   ++ LL +V
Sbjct  258  QKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPIIAQNLTLVKGSQKLLTQV  317

Query  314  NFQIPLGKKIVLTGSNGCGKSTLLRYIATNGEGLTISPKAKVGYFNQMSYQFKSEETVLQ  373
             FQIP GK+I L G+NG GK+TLL  I  + EG+  SPK +++Y+ Q++Y+   + ++LQ
Sbjct  318  RFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMAYYRQLAYEDMRDVSLLQ  377

Query  374  FLKNRADYDEGFLRNILSSMQFVGTDIQKSVNSLSGGEAIRLQLCYLFLGNYNILLLDEP  433
            +L + +D  E+F R IL+++  +   +++S N LSGGE  +L L  LF  + N+L+LDEP
Sbjct  378  YLMDETDSSESFSRAILNNLG-LNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEP  436

Query  434  TNFLDIQALEALEQFITAYEGTVIFVTHDKNFIENVAD  471
            TNFLDI++LEALE F+  Y G ++F +HD  F+ +V+D
Sbjct  437  TNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSD  474


 Score = 47.4 bits (160),  Expect = 2e-06, Method: Compositional matrix adjust.
 Identities = 45/161 (28%), Positives = 86/161 (54%), Gaps = 22/161 (13%)

Query  34   IGIVGKNGAGKSTLMKILASKIQPTSGIVKSHVHFGYFEQM------EAPMLV----EAE  83
            I++VG NG GK+TL+  +  +I+       + V+ +Y+ Q+      + ++L     E++
Sbjct  327  IALVGANGVGKTTLLEAIYHQIEGID--CSPKVQMAYYRQLAYEDMRDVSLLQYLMDETD  384

Query  84   GQ------LLGKLAIPS----NSEGLSGGEQTRLKLAQLFSYYKEALLIDEPTTHLDQEG  133
            +       +L +L++      + + LSGGE+T+L LA LFS   + L++DEPT  LD   
Sbjct  385  SSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIKT  444

Query  134  ISFLVDELRYYYGALVLISHDRAVLDELVTTIWEIDGGTVN  174
            +  L   +  Y G +++ SHD   + ++    WE+ G +++
Sbjct  445  LEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIH  485

5) OB0699 in NC_004193


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  303 bits (1134),  Expect = 2e-83, Method: Compositional matrix adjust.
 Identities = 200/488 (41%), Positives = 346/488 (71%), Gaps = 3/488 (0%)

Query  1    MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVgkngsgkssllkllagkIKPNKG  60
            ME+ ++ +++I+    D   L+I++L   QF++I+++G NG+GK++LL+++A K KP+ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   IVHQHASYAYFEQMEAPDLHLTGNEDPALLGKLHVPSQL-DSISGGEQTRLKLTQLLSEY  119
             V+  +   YFEQ++    +     D +L++ LH+P +  DS+SGGE+++ KL++++S+Y
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120

Query  120  REALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTLLDQLVSTIWEIH-DGSVFV  178
               L++DEPT HLD+ G  ++++ L YYYG+L++VSHDR+L+DQ+  TIW+I+ DG++ V
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  179  YAGNYTeyekqkqlefeqqqeAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEG  238
            + GNYT+Y++Q + E  +QQ    QY+ EK RL +A+  KR++A +M ++   +     +
Sbjct  181  FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA  240

Query  239  VNRMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPII  298
             +R+ A+K K++ +KA QK AK IEKR+++LEEV  P+S + +NF ++K  D+HN++PII
Sbjct  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300

Query  299  GDQLTLQAGDKVLLEEARFQFPLGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFG  358
            +++LTL  G + LL + RFQ+P G NIA+ G+NGVGK++LL+ I ++ +++D SPKV  +
Sbjct  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360

Query  359  YFQQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGNDLRKKLNQLSGGESIRLQ  418
            Y++QL+Y+   + ++L++L   T+  E+F R++L+++ ++ + L +  N LSGGE  +L 
Sbjct  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLN-EALDRSCNVLSGGERTKLS  419

Query  419  LSYLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVI  478
            L+ LF  K ++LILDEPTNFLDI T++ALE F + YPG I+F SHD  F+++V+ K+  +
Sbjct  420  LAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWEL  479

Query  479  QNKKLYEV  486
              + + ++
Sbjct  480  TGQSIHDI  487

6) EFAU004_02669 in NC_017022


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  295 bits (1106),  Expect = 4e-81, Method: Compositional matrix adjust.
 Identities = 212/491 (44%), Positives = 344/491 (71%), Gaps = 8/491 (1%)

Query  1    MENLAVNITNLQVSFGNQLELSIDSLRVYQQDRIGIIGENGVGKSTLLKLIAGELFPDHG  60
            ME+ ++++ +++  + +   L+I+ L  YQ ++I++IG NG GK+TLL++IA    P+ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KIQTEITFNYLPQLTYLAEA--KDLNLELASHFQLRLEETSERKWSGGEERKIELIRLLS  118
             ++T   ++Y+ QL    E   + L+  L S++++ ++ T     SGGE  K  L  ++S
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSM--SGGEKAKYKLANVIS  118

Query  119  SYEQGMLLDEPTTHLDRKSIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVK-DGEI  177
            +Y   +LLDEPT HLD+ + D L + L+YYYGTL++VSHDR ++D++A  IW+++ DG I
Sbjct  119  NYSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTI  178

Query  178  REFSGNYSAYLTQKELEKKTQLREAESIMKEKKRLEKSIqekkkqaeklekvsskkkkQQ  237
            R F GNY+ Y  Q E E+  Q R+ E  + EK+RL ++ + K++QA+++ + SSK+K++ 
Sbjct  179  RVFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKS  238

Query  238  IRPDRLSSSKQKDSVQKAIQKNAKTLERRLQKIGETTKPQQMKQIRFPVPKSLELHSRYP  297
            I PDRLS+SKQK++V+KA QK+AK +E+R++ + E  KPQ   ++ FP  K  ++H+ YP
Sbjct  239  IAPDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYP  298

Query  298  IMGQNVQLERSGRTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHIRKQGEGILLSPKVS  357
            I++QN+ L ++++ LL +  FQ++ GK+IA+VG NG GKTTLLE I  Q EGI  SPKV 
Sbjct  299  IIAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQ  358

Query  358  FQVYQQKGYQMTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCT-LSGGEAT  416
               Y+Q +Y+   + S+++++M +T+ SES+ R++LN+LG+ +E+L ++ C  LSGGE T
Sbjct  359  MAYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRS-CNVLSGGERT  416

Query  417  RLTIALLFTKPSNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEV  476
            +L++A+LF+  +N+L+LDEPTNF+D+ T+EALE +M+ YPG ILFTSHD+ FV + +D  
Sbjct  417  KLSLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKK  476

Query  477  YEIKGQKIKKV  487
             E+ GQ I  +
Sbjct  477  WELTGQSIHDI  487


 Score = 55.0 bits (189),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 50/165 (31%), Positives = 91/165 (56%), Gaps = 20/165 (12%)

Query  34   IGIIGENGVGKSTLLKLIAGELFPDHGKIQTEITFNYLPQLTYLAEAKDLNL--------  85
            I+++G NGVGK+TLL  I  ++  +       +   Y  QL+Y  + +D++L        
Sbjct  327  IALVGANGVGKTTLLEAIYHQI--EGIDCSPKVQMAYYRQLAY-EDMRDVSLLQYLMDET  383

Query  86   ELASHF------QLRLEETSERK---WSGGEERKIELIRLLSSYEQGMLLDEPTTHLDRK  136
            + +  F      +L L+E+ +R     SGGE  K+ L  L+S+  + ++LDEPT  LD K
Sbjct  384  DSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIK  443

Query  137  SIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVKDGEIREFS  181
            +++ L   +  Y G ++F SHD  F+ +++ K WE+ +  I++++
Sbjct  444  TLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHDIT  488


 Score = 54.5 bits (187),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 51/185 (28%), Positives = 109/185 (59%), Gaps = 20/185 (10%)

Query  310  RTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHI--RKQGEGILLSPKVSFQVYQQKGYQ  367
            R+L +   + + + K IA++G NG+GKTTLL+ I  + + E+  +     +Q ++Q   +
Sbjct  19   RSLNIGHLYAYQFEK-IALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQYFEQLNMD  77

Query  368  MTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCTLSGGEATRLTIALLFTKP  427
            +            + +F ++L  SL+++L ++ +T      ++SGGE ++  +A ++++ 
Sbjct  78   V------------ENDF-NTLDGSLMSELHIPMHTTD----SMSGGEKAKYKLANVISNY  120

Query  428  SNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEVYEIKGQKIKKV  487
            S +LLLDEPTN +D    + L ++++ Y GT+++ SHD  ++++ AD + +I+ +   +V
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  488  LTRNF  492
            +  N+
Sbjct  181  FKGNY  185

7) HMPREF0351_12617 in NC_017960


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  295 bits (1106),  Expect = 4e-81, Method: Compositional matrix adjust.
 Identities = 212/491 (44%), Positives = 344/491 (71%), Gaps = 8/491 (1%)

Query  1    MENLAVNITNLQVSFGNQLELSIDSLRVYQQDRIGIIGENGVGKSTLLKLIAGELFPDHG  60
            ME+ ++++ +++  + +   L+I+ L  YQ ++I++IG NG GK+TLL++IA    P+ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KIQTEITFNYLPQLTYLAEA--KDLNLELASHFQLRLEETSERKWSGGEERKIELIRLLS  118
             ++T   ++Y+ QL    E   + L+  L S++++ ++ T     SGGE  K  L  ++S
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSM--SGGEKAKYKLANVIS  118

Query  119  SYEQGMLLDEPTTHLDRKSIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVK-DGEI  177
            +Y   +LLDEPT HLD+ + D L + L+YYYGTL++VSHDR ++D++A  IW+++ DG I
Sbjct  119  NYSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTI  178

Query  178  REFSGNYSAYLTQKELEKKTQLREAESIMKEKKRLEKSIqekkkqaeklekvsskkkkQQ  237
            R F GNY+ Y  Q E E+  Q R+ E  + EK+RL ++ + K++QA+++ + SSK+K++ 
Sbjct  179  RVFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKS  238

Query  238  IRPDRLSSSKQKDSVQKAIQKNAKTLERRLQKIGETTKPQQMKQIRFPVPKSLELHSRYP  297
            I PDRLS+SKQK++V+KA QK+AK +E+R++ + E  KPQ   ++ FP  K  ++H+ YP
Sbjct  239  IAPDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYP  298

Query  298  IMGQNVQLERSGRTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHIRKQGEGILLSPKVS  357
            I++QN+ L ++++ LL +  FQ++ GK+IA+VG NG GKTTLLE I  Q EGI  SPKV 
Sbjct  299  IIAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQ  358

Query  358  FQVYQQKGYQMTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCT-LSGGEAT  416
               Y+Q +Y+   + S+++++M +T+ SES+ R++LN+LG+ +E+L ++ C  LSGGE T
Sbjct  359  MAYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRS-CNVLSGGERT  416

Query  417  RLTIALLFTKPSNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEV  476
            +L++A+LF+  +N+L+LDEPTNF+D+ T+EALE +M+ YPG ILFTSHD+ FV + +D  
Sbjct  417  KLSLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKK  476

Query  477  YEIKGQKIKKV  487
             E+ GQ I  +
Sbjct  477  WELTGQSIHDI  487


 Score = 55.0 bits (189),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 50/165 (31%), Positives = 91/165 (56%), Gaps = 20/165 (12%)

Query  34   IGIIGENGVGKSTLLKLIAGELFPDHGKIQTEITFNYLPQLTYLAEAKDLNL--------  85
            I+++G NGVGK+TLL  I  ++  +       +   Y  QL+Y  + +D++L        
Sbjct  327  IALVGANGVGKTTLLEAIYHQI--EGIDCSPKVQMAYYRQLAY-EDMRDVSLLQYLMDET  383

Query  86   ELASHF------QLRLEETSERK---WSGGEERKIELIRLLSSYEQGMLLDEPTTHLDRK  136
            + +  F      +L L+E+ +R     SGGE  K+ L  L+S+  + ++LDEPT  LD K
Sbjct  384  DSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIK  443

Query  137  SIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVKDGEIREFS  181
            +++ L   +  Y G ++F SHD  F+ +++ K WE+ +  I++++
Sbjct  444  TLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHDIT  488


 Score = 54.5 bits (187),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 51/185 (28%), Positives = 109/185 (59%), Gaps = 20/185 (10%)

Query  310  RTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHI--RKQGEGILLSPKVSFQVYQQKGYQ  367
            R+L +   + + + K IA++G NG+GKTTLL+ I  + + E+  +     +Q ++Q   +
Sbjct  19   RSLNIGHLYAYQFEK-IALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQYFEQLNMD  77

Query  368  MTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCTLSGGEATRLTIALLFTKP  427
            +            + +F ++L  SL+++L ++ +T      ++SGGE ++  +A ++++ 
Sbjct  78   V------------ENDF-NTLDGSLMSELHIPMHTTD----SMSGGEKAKYKLANVISNY  120

Query  428  SNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEVYEIKGQKIKKV  487
            S +LLLDEPTN +D    + L ++++ Y GT+++ SHD  ++++ AD + +I+ +   +V
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  488  LTRNF  492
            +  N+
Sbjct  181  FKGNY  185

8) M7W_2629 in NC_020207


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  295 bits (1106),  Expect = 4e-81, Method: Compositional matrix adjust.
 Identities = 212/491 (44%), Positives = 344/491 (71%), Gaps = 8/491 (1%)

Query  1    MENLAVNITNLQVSFGNQLELSIDSLRVYQQDRIGIIGENGVGKSTLLKLIAGELFPDHG  60
            ME+ ++++ +++  + +   L+I+ L  YQ ++I++IG NG GK+TLL++IA    P+ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KIQTEITFNYLPQLTYLAEA--KDLNLELASHFQLRLEETSERKWSGGEERKIELIRLLS  118
             ++T   ++Y+ QL    E   + L+  L S++++ ++ T     SGGE  K  L  ++S
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSM--SGGEKAKYKLANVIS  118

Query  119  SYEQGMLLDEPTTHLDRKSIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVK-DGEI  177
            +Y   +LLDEPT HLD+ + D L + L+YYYGTL++VSHDR ++D++A  IW+++ DG I
Sbjct  119  NYSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTI  178

Query  178  REFSGNYSAYLTQKELEKKTQLREAESIMKEKKRLEKSIqekkkqaeklekvsskkkkQQ  237
            R F GNY+ Y  Q E E+  Q R+ E  + EK+RL ++ + K++QA+++ + SSK+K++ 
Sbjct  179  RVFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKS  238

Query  238  IRPDRLSSSKQKDSVQKAIQKNAKTLERRLQKIGETTKPQQMKQIRFPVPKSLELHSRYP  297
            I PDRLS+SKQK++V+KA QK+AK +E+R++ + E  KPQ   ++ FP  K  ++H+ YP
Sbjct  239  IAPDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYP  298

Query  298  IMGQNVQLERSGRTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHIRKQGEGILLSPKVS  357
            I++QN+ L ++++ LL +  FQ++ GK+IA+VG NG GKTTLLE I  Q EGI  SPKV 
Sbjct  299  IIAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQ  358

Query  358  FQVYQQKGYQMTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCT-LSGGEAT  416
               Y+Q +Y+   + S+++++M +T+ SES+ R++LN+LG+ +E+L ++ C  LSGGE T
Sbjct  359  MAYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRS-CNVLSGGERT  416

Query  417  RLTIALLFTKPSNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEV  476
            +L++A+LF+  +N+L+LDEPTNF+D+ T+EALE +M+ YPG ILFTSHD+ FV + +D  
Sbjct  417  KLSLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKK  476

Query  477  YEIKGQKIKKV  487
             E+ GQ I  +
Sbjct  477  WELTGQSIHDI  487


 Score = 55.0 bits (189),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 50/165 (31%), Positives = 91/165 (56%), Gaps = 20/165 (12%)

Query  34   IGIIGENGVGKSTLLKLIAGELFPDHGKIQTEITFNYLPQLTYLAEAKDLNL--------  85
            I+++G NGVGK+TLL  I  ++  +       +   Y  QL+Y  + +D++L        
Sbjct  327  IALVGANGVGKTTLLEAIYHQI--EGIDCSPKVQMAYYRQLAY-EDMRDVSLLQYLMDET  383

Query  86   ELASHF------QLRLEETSERK---WSGGEERKIELIRLLSSYEQGMLLDEPTTHLDRK  136
            + +  F      +L L+E+ +R     SGGE  K+ L  L+S+  + ++LDEPT  LD K
Sbjct  384  DSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIK  443

Query  137  SIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVKDGEIREFS  181
            +++ L   +  Y G ++F SHD  F+ +++ K WE+ +  I++++
Sbjct  444  TLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHDIT  488


 Score = 54.5 bits (187),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 51/185 (28%), Positives = 109/185 (59%), Gaps = 20/185 (10%)

Query  310  RTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHI--RKQGEGILLSPKVSFQVYQQKGYQ  367
            R+L +   + + + K IA++G NG+GKTTLL+ I  + + E+  +     +Q ++Q   +
Sbjct  19   RSLNIGHLYAYQFEK-IALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQYFEQLNMD  77

Query  368  MTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCTLSGGEATRLTIALLFTKP  427
            +            + +F ++L  SL+++L ++ +T      ++SGGE ++  +A ++++ 
Sbjct  78   V------------ENDF-NTLDGSLMSELHIPMHTTD----SMSGGEKAKYKLANVISNY  120

Query  428  SNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEVYEIKGQKIKKV  487
            S +LLLDEPTN +D    + L ++++ Y GT+++ SHD  ++++ AD + +I+ +   +V
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  488  LTRNF  492
            +  N+
Sbjct  181  FKGNY  185

9) EFAU085_02754 in NC_021994


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  292 bits (1092),  Expect = 4e-80, Method: Compositional matrix adjust.
 Identities = 211/491 (43%), Positives = 343/491 (70%), Gaps = 8/491 (1%)

Query  1    MENLAVNITNLQVSFGNQLELSIDSLRVYQQDRIGIIGENGVGKSTLLKLIAGELFPDHG  60
            ME+ ++++ +++  + +   L+I+ L  YQ ++I++IG NG GK+TLL++IA    P+ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KIQTEITFNYLPQLTYLAEA--KDLNLELASHFQLRLEETSERKWSGGEERKIELIRLLS  118
             ++T   ++Y+ QL    E   + L+  L S++++ ++ T     SGGE  K  L  ++S
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSM--SGGEKAKYKLANVIS  118

Query  119  SYEQGMLLDEPTTHLDRKSIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVK-DGEI  177
            +Y   +LLDEPT HLD+ + D L + L+YYYGTL++VSHDR ++D++A  IW+++ DG I
Sbjct  119  NYSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTI  178

Query  178  REFSGNYSAYLTQKELEKKTQLREAESIMKEKKRLEKSIqekkkqaeklekvsskkkkQQ  237
            R F GNY+ Y  Q E E+  Q R+ E  + EK+RL ++ + K++QA+++ + SSK+K++ 
Sbjct  179  RVFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKS  238

Query  238  IRLDRLSSSKQKDSVQKAIQKNAKTLERRLQKIGETTKPQQMKQIRFPVPKSLELHSRYP  297
            I  DRLS+SKQK++V+KA QK+AK +E+R++ + E  KPQ   ++ FP  K  ++H+ YP
Sbjct  239  IAPDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYP  298

Query  298  IMGQNVQLERSGRTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHIRKQGEGILLSPKVS  357
            I++QN+ L ++++ LL +  FQ++ GK+IA+VG NG GKTTLLE I  Q EGI  SPKV 
Sbjct  299  IIAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQ  358

Query  358  FQVYQQKGYQMTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCT-LSGGEAT  416
               Y+Q +Y+   + S+++++M +T+ SES+ R++LN+LG+ +E+L ++ C  LSGGE T
Sbjct  359  MAYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRS-CNVLSGGERT  416

Query  417  RLTIALLFTKPSNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEV  476
            +L++A+LF+  +N+L+LDEPTNF+D+ T+EALE +M+ YPG ILFTSHD+ FV + +D  
Sbjct  417  KLSLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKK  476

Query  477  YEIKGQKIKKV  487
             E+ GQ I  +
Sbjct  477  WELTGQSIHDI  487


 Score = 55.0 bits (189),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 50/165 (31%), Positives = 91/165 (56%), Gaps = 20/165 (12%)

Query  34   IGIIGENGVGKSTLLKLIAGELFPDHGKIQTEITFNYLPQLTYLAEAKDLNL--------  85
            I+++G NGVGK+TLL  I  ++  +       +   Y  QL+Y  + +D++L        
Sbjct  327  IALVGANGVGKTTLLEAIYHQI--EGIDCSPKVQMAYYRQLAY-EDMRDVSLLQYLMDET  383

Query  86   ELASHF------QLRLEETSERK---WSGGEERKIELIRLLSSYEQGMLLDEPTTHLDRK  136
            + +  F      +L L+E+ +R     SGGE  K+ L  L+S+  + ++LDEPT  LD K
Sbjct  384  DSSESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIK  443

Query  137  SIDRLIEELRYYYGTLVFVSHDRYFLDELASKIWEVKDGEIREFS  181
            +++ L   +  Y G ++F SHD  F+ +++ K WE+ +  I++++
Sbjct  444  TLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHDIT  488


 Score = 54.5 bits (187),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 51/185 (28%), Positives = 109/185 (59%), Gaps = 20/185 (10%)

Query  310  RTLLVNGDFQFSLGKKIAIVGENGSGKTTLLEHI--RKQGEGILLSPKVSFQVYQQKGYQ  367
            R+L +   + + + K IA++G NG+GKTTLL+ I  + + E+  +     +Q ++Q   +
Sbjct  19   RSLNIGHLYAYQFEK-IALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQYFEQLNMD  77

Query  368  MTSEESIIRFVMRQTEFSESLVRSLLNHLGFAQETLTKPLCTLSGGEATRLTIALLFTKP  427
            +            + +F ++L  SL+++L ++ +T      ++SGGE ++  +A ++++ 
Sbjct  78   V------------ENDF-NTLDGSLMSELHIPMHTTD----SMSGGEKAKYKLANVISNY  120

Query  428  SNVLLLDEPTNFIDMATIEALEKLMQIYPGTILFTSHDSYFVERTADEVYEIKGQKIKKV  487
            S +LLLDEPTN +D    + L ++++ Y GT+++ SHD  ++++ AD + +I+ +   +V
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  488  LTRNF  492
            +  N+
Sbjct  181  FKGNY  185

10) ECBG_00224 in NC_020995


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  291 bits (1089),  Expect = 8e-80, Method: Compositional matrix adjust.
 Identities = 203/475 (43%), Positives = 329/475 (70%), Gaps = 3/475 (0%)

Query  1    MEQLSVKINNLIKNYGSKEVLNIEELSTYQTDRIGIVGANGQGKSTLLKLIAGVVDPDSG  60
            MEQ ++K+N++  +      LNI +L +YQ ++I+++G+NG GK+TLL++IA    P+SG
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   TIQKENSFYYFPQIA-EVTEKTDALDWALFGRFSIPTNELATLSGGEETKYRLAQTLSSY  119
            T++    + YF Q+  +V +  ++LD +L + + IP +   ++SGGE +KY+LA+ +S+Y
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLANVISNY  120

Query  120  QLGLLLDEPTTHLDQQGIQVLIEELQYYYGTLIVVSHDRYLLNQLATKIWEV-DQGKVTE  178
               LLLDEPT HLD+ G + L + L+YYYGTLI+VSHDR L++Q+A  IW++ ++G +  
Sbjct  121  SPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRV  180

Query  179  YAGNYDSYRQQKEQAAQRVaweaaqyqqqkqqltqaiqkkkeqaikSSRISEKKRQQNIR  238
            + GNY  Y++Q EQ      ++  QY  +KQ+L+QA + K++QA + ++ S K+++++I 
Sbjct  181  FKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIA  240

Query  239  PDRLSSSKQKDTVQKSLQKTVKAMESRLDQLEEVKGVARQQVIRFPVVPAVELHNKRPIR  298
            PDRLS+SKQK+TV+K+ QK  K +E R+++LEEV      + + FP     ++HN+ PI 
Sbjct  241  PDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPII  300

Query  299  GEQVTIQRGAKRLLDSSSFQFAAGKKIAIVGPNGSGKSTLLKEIIAGGEGIYVSPKIVFA  358
            ++++T+ +G+++LL    FQ++ GK+IA+VG+NG GK+TLL  I    EGI  SPK+  A
Sbjct  301  AQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMA  360

Query  359  VYEQMGYRKNSTTPLLTELMAQTDYQEPLVRSILHNLGFSQIDVMKPVNVLSGGEATRVE  418
             Y Q++Y      +LL  LM +TD  E++ R+IL+NLG+++  + ++ NVLSGGE T++ 
Sbjct  361  YYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNE-ALDRSCNVLSGGERTKLS  419

Query  419  LARIFTQPANVLILDEPTNFIDLPTITVLEQLIRSYRGMVLFTSHDQAFIDAVAD  473
            LA +F+  AN+LILDEPTNF+D+ T+  LE ++  Y G++LFTSHD  F+  V+D
Sbjct  420  LAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSD  474


 Score = 51.6 bits (176),  Expect = 1e-07, Method: Compositional matrix adjust.
 Identities = 48/170 (29%), Positives = 98/170 (58%), Gaps = 26/170 (15%)

Query  316  SFQFAAGKKIAIVGPNGSGKSTLLKEII----AGGEGIYVSPKIVFAVYEQMGYRKNSTT  371
            ++QF    KIA++G NG+GK+TLL+ I     + +  +     I +  +EQ+        
Sbjct  28   AYQFE---KIALIGGNGTGKTTLLNMIAQKTKPESGTVETVGEIQY--FEQL--------  74

Query  372  PLLTELMAQTDYQEPLVRSILHNLGFSQIDVMKPVNVLSGGEATRVELARIFTQPANVLI  431
                ++  + D+ + L  S++ +L ++    M   + +SGGE ++  LA ++++ + +L+
Sbjct  75   ----NMDVENDF-NTLDGSLMSELHIP----MHTTDSMSGGEKAKYKLANVISNYSPILL  125

Query  432  LDEPTNFIDLPTITVLEQLIRSYRGMVLFTSHDQAFIDAVADDVYQIDHG  481
            LDEPTN +D      L ++++ Y G +++ SHD+A+ID +AD + +I+++
Sbjct  126  LDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQED  175


 Score = 42.9 bits (143),  Expect = 5e-05, Method: Compositional matrix adjust.
 Identities = 43/160 (27%), Positives = 87/160 (55%), Gaps = 15/160 (9%)

Query  34   IGIVGANGQGKSTLLKLIAGVVDPDSGTIQKENSFY---YFPQIAEV---------TEKT  81
            I++VGANG GK+TLL  I   ++    + + + ++Y    + ++ +V         T+ +
Sbjct  327  IALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMAYYRQLAYEDMRDVSLLQYLMDETDSS  386

Query  82   DALDWALFGRFSIPTN---ELATLSGGEETKYRLAQTLSSYQLGLLLDEPTTHLDQQGIQ  138
            +++ +A++  +++          LSGGE TK  LA  +S+    L+LDEPT  LD + ++
Sbjct  387  ESFSRAILNNLGLNEALDRSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIKTLE  446

Query  139  VLIEELQYYYGTLIVVSHDRYLLNQLATKIWEVDQGKVTE  178
             L   ++ Y G ++  SHD  ++++++ K WE+    + +
Sbjct  447  ALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHD  486

11) msrA in NC_017316


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  252 bits (940),  Expect = 5e-68, Method: Compositional matrix adjust.
 Identities = 195/477 (41%), Positives = 322/477 (68%), Gaps = 9/477 (1%)

Query  17   MKKLSIHLKEVNIHFSGKPILEIDELFVYENEkigiigkngagkSTLLNLIMGKIQSDKG  76
            M + +I ++++N  +++   L+I++L+ Y+ EKI++IG NG+GK+TLLN+I  K +++ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  77   KVQRLNDFHYLAQVAEEITNESEKTDKNCLLN------QKNQKLSGGEKVQKRLATLFSE  130
             V+ + +++Y+ Q+  ++ N+ +  D   L++      +  + +SGGEK + +LA ++S+
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLD-GSLMSELHIPMHTTDSMSGGEKAKYKLANVISN  119

Query  131  YPTGVILDEPTTHLDKEHRQLLVADLTYYYGTVLFVSHDRFFLNQLAEKIWEV-SDGHVK  189
            Y+  ++LDEPT HLDK  ++ L   L YYYGT+++VSHDR +++Q+A+ IW++  DG ++
Sbjct  120  YSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIR  179

Query  190  EYLGNYDAYCRQKELEQQTQYNVYHQYQKEKKKLQESYakkqaqaqksshvskkqkqkqi  249
             + GNY  Y  Q E EQ  Q   Y+QY  EK++L ++   K+ QAQ+ ++ S KQK+K I
Sbjct  180  VFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSI  239

Query  250  kPSRLAGSKQKDTVQKALQKQAKAINARIDRLPDVAQAKQERKIIFPTNNQFSLYNPYPI  309
             P RL++SKQK+TV+KA QKQAK I+ R+++L +V +++  + + FP N+ + + N YPI
Sbjct  240  APDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPI  299

Query  310  RIENLTFAYENRTILNQVNVQIPLNEKIALCGKNGAGKSTFLQQIEARHPAIYFSPKVRL  369
              +NLT+   ++ +L QV  QIP   +IAL G NG GK+T+L+ I  +  +I  SPKV++
Sbjct  300  IAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQM  359

Query  370  GTYHQLDYRLKNDEPLLTYLLKRTNYSEKIVRSLLYRLGFQQENLQTKISSLSGGEAIKI  429
            + Y+QL Y    D +LL YL+  T+ SE + R++L  LG+ +E L+   + LSGGE  K+
Sbjct  360  AYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRSCNVLSGGERTKL  418

Query  430  TLAQLFIEPNNIILLDEPTNFLDLETIQALEEFISAYQGTVIFTSHDETFVEKVATR  486
            +LA LF    N+++LDEPTNFLD+ T++ALE F++ Y G ++FTSHD  FV  V+ +
Sbjct  419  SLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDK  475

12) EF1413 in NC_004668


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  251 bits (936),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 194/477 (41%), Positives = 322/477 (68%), Gaps = 9/477 (1%)

Query  1    MKKLSIHLKDVSIHFSGKPILEIDELFVYENEkigiigkngagkSTLLNLIMGKIQSDKG  60
            M + +I +++++  +++   L+I++L+ Y+ EKI++IG NG+GK+TLLN+I  K +++ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KVQRLNDFHYLAQVAEEITNESEKTDKNCLLN------QKNQKLSGGEKVQKRLATLFSE  114
             V+ + +++Y+ Q+  ++ N+ +  D   L++      +  + +SGGEK + +LA ++S+
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLD-GSLMSELHIPMHTTDSMSGGEKAKYKLANVISN  119

Query  115  YPTGVILDEPTTHLDKEHRQLLVADLTYYYGTVLFVSHDRFFLNQLAEKIWEV-SDGHVK  173
            Y+  ++LDEPT HLDK  ++ L   L YYYGT+++VSHDR +++Q+A+ IW++  DG ++
Sbjct  120  YSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIR  179

Query  174  EYLGNYDAYCRQKELEQQTQYNVYHQYQKEKKKLQESYakkqaqaqksshvskkqkqkqi  233
             + GNY  Y  Q E EQ  Q   Y+QY  EK++L ++   K+ QAQ+ ++ S KQK+K I
Sbjct  180  VFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSI  239

Query  234  kPSRLAGSKQKDTVQKALQKQAKAINARIDRLPDVAQAKQERKIIFPTNNQFSLYNPYPI  293
             P RL++SKQK+TV+KA QKQAK I+ R+++L +V +++  + + FP N+ + + N YPI
Sbjct  240  APDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPI  299

Query  294  RIENLTFAYENRTILNQVNVQIPLNEKIALCGKNGAGKSTFLQQIEARHPAIYFSPKVRL  353
              +NLT+   ++ +L QV  QIP   +IAL G NG GK+T+L+ I  +  +I  SPKV++
Sbjct  300  IAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQM  359

Query  354  GTYHQLDYRLKNDEPLLTYLLKRTNYSEKIVRSLLYRLGFQQENLQTKISSLSGGEAIKI  413
            + Y+QL Y    D +LL YL+  T+ SE + R++L  LG+ +E L+   + LSGGE  K+
Sbjct  360  AYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRSCNVLSGGERTKL  418

Query  414  TLAQLFIEPNNIILLDEPTNFLDLDTIQALEEFISAYQGTVIFTSHDETFVEKVATR  470
            +LA LF    N+++LDEPTNFLD+ T++ALE F++ Y G ++FTSHD  FV  V+ +
Sbjct  419  SLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDK  475

13) EFD32_1226 in NC_018221


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  251 bits (937),  Expect = 8e-68, Method: Compositional matrix adjust.
 Identities = 194/477 (41%), Positives = 322/477 (68%), Gaps = 9/477 (1%)

Query  17   MKKLSIHLKDVSIHFSGKPILEIDELFVYENEkigiigkngagkSTLLNLIMGKIQSDKG  76
            M + +I +++++  +++   L+I++L+ Y+ EKI++IG NG+GK+TLLN+I  K +++ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  77   KVQRLNDFHYLAQVAEEITNESEKTDKNCLLN------QKNQKLSGGEKVQKRLATLFSE  130
             V+ + +++Y+ Q+  ++ N+ +  D   L++      +  + +SGGEK + +LA ++S+
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLD-GSLMSELHIPMHTTDSMSGGEKAKYKLANVISN  119

Query  131  YPTGVILDEPTTHLDKEHRQLLVADLTYYYGTVLFVSHDRFFLNQLAEKIWEV-SDGHVK  189
            Y+  ++LDEPT HLDK  ++ L   L YYYGT+++VSHDR +++Q+A+ IW++  DG ++
Sbjct  120  YSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIR  179

Query  190  EYLGNYDAYCRQKELEQQTQYNVYHQYQKEKKKLQESYakkqaqaqksshvskkqkqkqi  249
             + GNY  Y  Q E EQ  Q   Y+QY  EK++L ++   K+ QAQ+ ++ S KQK+K I
Sbjct  180  VFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSI  239

Query  250  kPSRLAGSKQKDTVQKALQKQAKAINARIDRLPDVAQAKQERKIIFPTNNQFSLYNPYPI  309
             P RL++SKQK+TV+KA QKQAK I+ R+++L +V +++  + + FP N+ + + N YPI
Sbjct  240  APDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPI  299

Query  310  RIENLTFAYENRTILNQVNVQIPLNEKIALCGKNGAGKSTFLQQIEARHPAIYFSPKVRL  369
              +NLT+   ++ +L QV  QIP   +IAL G NG GK+T+L+ I  +  +I  SPKV++
Sbjct  300  IAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQM  359

Query  370  GTYHQLDYRLKNDEPLLTYLLKRTNYSEKIVRSLLYRLGFQQENLQTKISSLSGGEAIKI  429
            + Y+QL Y    D +LL YL+  T+ SE + R++L  LG+ +E L+   + LSGGE  K+
Sbjct  360  AYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRSCNVLSGGERTKL  418

Query  430  TLAQLFIEPNNIILLDEPTNFLDLDTIQALEEFISAYQGTVIFTSHDETFVEKVATR  486
            +LA LF    N+++LDEPTNFLD+ T++ALE F++ Y G ++FTSHD  FV  V+ +
Sbjct  419  SLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDK  475

14) EFS1_1238 in NC_019770


> NC_007168_R3|10|G10|70727304|YP_254220.1|Staphylococcus_haemolyticus_JCSC1435|+|4883..6349|msrSA|SH2305|erythromycin 
resistance 
protein
Length=488

 Score =  250 bits (935),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 192/477 (41%), Positives = 321/477 (68%), Gaps = 9/477 (1%)

Query  1    MKKLSIHLKEVSIHFSGKPILEIDELFVYENEkigiigkngagkSTLLNLIMGKIQSDKG  60
            M + +I +++++  +++   L+I++L+ Y+ EKI++IG NG+GK+TLLN+I  K +++ G
Sbjct  1    MEQYTIKFNQINHKLTDLRSLNIGHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESG  60

Query  61   KVQRLNDFHYLAQVAEEITNEPEKTDKNCLLN------QKNQKLSGGEKVQKRLATLFSE  114
             V+ + +++Y+ Q+  ++ N+ +  D   L++      +  + +SGGEK + +LA ++S+
Sbjct  61   TVETVGEIQYFEQLNMDVENDFNTLD-GSLMSELHIPMHTTDSMSGGEKAKYKLANVISN  119

Query  115  YPTGVILDEPTTHLDKEHRQLLVADLTYYYGTVLFVSHDRFFLNQLAEKIWEV-SDGHVK  173
            Y+  ++LDEPT HLDK  ++ L   L YYYGT+++VSHDR +++Q+A+ IW++  DG ++
Sbjct  120  YSPILLLDEPTNHLDKIGKDYLKNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIR  179

Query  174  EYLGNYDAYCRQKELEQQTRYNVCHQYQKEKKKLQESYakkqaqaqksshvskkqkqkqi  233
             + GNY  Y  Q E EQ  +    +QY  EK++L ++   K+ QAQ+ ++ S KQK+K I
Sbjct  180  VFKGNYTQYQNQYEQEQLEQQRQYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSI  239

Query  234  kPSRLAGSKQKDTVQKALQKQAKAINARIDRLPDVAQAKQERKIIFPTNNQFSLYNPYPI  293
             P RL++SKQK+TV+KA QKQAK I+ R+++L +V +++  + + FP N+ + + N YPI
Sbjct  240  APDRLSASKQKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPI  299

Query  294  RIENLTFAYENRTILNQVNVQIPVNEKIALCGKNGAGKSTFLQQIEARHPAIYFSPKVRL  353
              +NLT+   ++ +L QV  QIP   +IAL G NG GK+T+L+ I  +  +I  SPKV++
Sbjct  300  IAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQM  359

Query  354  GTYHQLDYRLKNDEPLLTYLLKRTNYSEKIVRSLLYRLGFQQENLQTKISSLSGGEAIKI  413
            + Y+QL Y    D +LL YL+  T+ SE + R++L  LG+ +E L+   + LSGGE  K+
Sbjct  360  AYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGL-NEALDRSCNVLSGGERTKL  418

Query  414  TLAQLFIEPNNIILLDEPTNFLDLETIQALEEFISAYQGTVIFTSHDETFVEKVATR  470
            +LA LF    N+++LDEPTNFLD+ T++ALE F++ Y G ++FTSHD  FV  V+ +
Sbjct  419  SLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDK  475