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Homologs of dfrA1 gene of JF262176

protein-level

Hit (GenBank Accn)

Product

Source Genome

Eval.

Ident.(%)

1) dhfrV
( YP_001740004.1 )

dihydrofolate reductase type 5

NC_010488
(Escherichia coli SMS-3-5)

4e-65

2) dhfR
( NP_569370.1 )

dihydrofolate reductase

NC_003384
(Salmonella enterica CT18)

4e-65

3) ST548_p1188
( YP_007386304.1 )

Dihydrofolate reductase

NC_020180
(Enterobacter aerogenes EA1509E)

1e-55

4) NRG857_30100
( YP_006162239.1 )

dihydrofolate reductase type I DhfrA1

NC_017659
(Escherichia coli NRG 857C)

1e-55

5) A225_R1p0435
( YP_006501701.1 )

Dhfr1

NC_018107
(Klebsiella oxytoca E718)

1e-55

6) dhfrI
( YP_001715373.1 )

dihydrofolate reductase type 1 (dihydrofolate reductase type I) (trimethoprim resistance protein)

NC_010410
(Acinetobacter baumannii AYE)

2e-55

7) SFxv_4142a
( YP_005729392.1 )

trimethoprim resistance protein,type I dihydrofolate reductase

NC_017328
(Shigella flexneri 2002017)

2e-55

8) DP0311
( YP_064047.1 )

dihydrofolate reductase, type VII

NC_006138
(Desulfotalea psychrophila LSv54)

1e-49

9) O3M_00535
( YP_006767792.1 )

dihydrofolate reductase

NC_018650
(Escherichia coli 2009EL-2050)

8e-49

10) O3O_25165
( YP_006781897.1 )

dihydrofolate reductase

NC_018661
(Escherichia coli 2009EL-2071)

8e-49

11) O3K_00505
( YP_006776837.1 )

dihydrofolate reductase

NC_018658
(Escherichia coli 2011C-3493)

8e-49

12) Kfla_5968
( YP_003383770.1 )

dihydrofolate reductase

NC_013729
(Kribbella flavida DSM 17836)

1e-19

13) Noca_2312
( YP_923504.1 )

dihydrofolate reductase

NC_008699
(Nocardioides sp. JS614)

4e-19

14) Intca_2184
( YP_004099420.1 )

dihydrofolate reductase

NC_014830
(Intrasporangium calvum DSM 43043)

4e-18

15) UMN179_01397
( YP_004420313.1 )

dihydrofolate reductase

NC_015460
(Gallibacterium anatis UMN179)

3e-16

16) folA
( YP_004574294.1 )

dihydrofolate reductase

NC_015635
(Microlunatus phosphovorus NM-1)

6e-16

17) Mpop_2781
( YP_001925471.1 )

dihydrofolate reductase

NC_010725
(Methylobacterium populi BJ001)

2e-15

18) Tbd_2039
( YP_315797.1 )

dihydrofolate reductase

NC_007404
(Thiobacillus denitrificans ATCC 25259)

2e-15

19) KPHS_p300720
( YP_005221020.1 )

dihydrofolate reductase

NC_016839
(Klebsiella pneumoniae HS11286)

2e-15

20) Ccel_1310
( YP_002505644.1 )

dihydrofolate reductase subunit

NC_011898
(Clostridium cellulolyticum H10)

6e-15

21) folA
( YP_004833673.1 )

dihydrofolate reductase

NC_015976
(Sphingobium sp. SYK-6)

2e-14

22) folA
( YP_002773868.1 )

dihydrofolate reductase

NC_012491
(Brevibacillus brevis NBRC 100599)

6e-14

23) Runsl_2666
( YP_004656198.1 )

dihydrofolate reductase

NC_015703
(Runella slithyformis DSM 19594)

2e-13

24) RPD_3353
( YP_570478.1 )

dihydrofolate reductase

NC_007958
(Rhodopseudomonas palustris BisB5)

3e-13

25) Mlg_0423
( YP_741267.1 )

dihydrofolate reductase

NC_008340
(Alkalilimnicola ehrlichii MLHE-1)

3e-11

26) Theco_1713
( YP_007212843.1 )

dihydrofolate reductase

NC_019897
(Thermobacillus composti KWC4)

7e-11

• Sequence Alignments

1) dhfrV in NC_010488


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  240 bits (894),  Expect = 4e-65, Method: Compositional matrix adjust.
 Identities = 141/157 (90%), Positives = 154/157 (99%), Gaps = 0/157 (0%)

Query  4    LKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  63
            +KVSLMAAKAKNGVIGCGP+IPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  64   VVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDI  123
            VVTRS+WT+++DNV+VF SIEEAM  LAE+T+HVIVSGGGEIYRETLPMASTLH+STIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  124  EPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            EPEGDVFFP+IPNTFEVVFEQHF+SNINYCYQIW+KG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

2) dhfR in NC_003384


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  240 bits (894),  Expect = 4e-65, Method: Compositional matrix adjust.
 Identities = 141/157 (90%), Positives = 154/157 (99%), Gaps = 0/157 (0%)

Query  4    LKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  63
            +KVSLMAAKAKNGVIGCGP+IPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  64   VVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDI  123
            VVTRS+WT+++DNV+VF SIEEAM  LAE+T+HVIVSGGGEIYRETLPMASTLH+STIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  124  EPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG  160
            EPEGDVFFP+IPNTFEVVFEQHF+SNINYCYQIW+KG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

3) ST548_p1188 in NC_020180


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  209 bits (776),  Expect = 1e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

4) NRG857_30100 in NC_017659


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  209 bits (776),  Expect = 1e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

5) A225_R1p0435 in NC_018107


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  209 bits (776),  Expect = 1e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

6) dhfrI in NC_010410


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  208 bits (773),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

7) SFxv_4142a in NC_017328


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  208 bits (773),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

8) VCD_003671 in NC_012668


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  208 bits (773),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

9) dfrA1 in NC_016445


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  208 bits (773),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 118/157 (76%), Positives = 137/157 (88%), Gaps = 0/157 (0%)

Query  1    MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA  60
            MK+SLM A +KNGVIG GP+IPWSAKGEQLLFKA+TYNQWLLVGRKTFESMGALPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI  120
            VVTRS+ T+DN+NV++FPSI +A+  L  +TDHVIVSGGGEIY+  +    TLHISTIDI
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG  157
            EPEGDV+FP+IP+ F  VF Q+F+SNINY YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

10) DP0311 in NC_006138


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  188 bits (699),  Expect = 1e-49, Method: Compositional matrix adjust.
 Identities = 101/156 (65%), Positives = 133/156 (86%), Gaps = 0/156 (0%)

Query  1    MKISLMAAKSENGVIGKGADIPWMVKGEQLLFKAITFNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SLMAAK+ NGVIG G++IPW  KGEQLLFKA+T+NQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VITRSGLLSQNDNVLVFPSIEDALRELAQQTEHIIVAGGGEIFKAMINRADTLHLSTVHQ  120
            V+TRS+  ++NDNV+VFPSIE+A+  LA+ T+H+IV+GGGEI++  +  A TLH+ST++ 
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  NIDGDITFPQVPKDFKLVFEQYFESNINYTYQIWQR  156
            + +GD+ FP++P+ F +VFEQ F SNINY YQIWQ+
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQK  156

11) O3M_00535 in NC_018650


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  186 bits (689),  Expect = 8e-49, Method: Compositional matrix adjust.
 Identities = 103/157 (66%), Positives = 132/157 (85%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

12) O3O_25165 in NC_018661


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  186 bits (689),  Expect = 8e-49, Method: Compositional matrix adjust.
 Identities = 103/157 (66%), Positives = 132/157 (85%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

13) O3K_00505 in NC_018658


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  186 bits (689),  Expect = 8e-49, Method: Compositional matrix adjust.
 Identities = 103/157 (66%), Positives = 132/157 (85%), Gaps = 0/157 (0%)

Query  1    MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA  60
            MK+SL++A + NGVIG GP+IPWSAKGEQLLFKALTYNQWLLVGRKTF+SMG LPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  61   VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV  120
            VV+R + ++ N+NV+VFPSIE A+  L+ +TDH+ VSGGG+IY   +  A  +H+ST+++
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  121  EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG  157
            E EGD+ FP+IP+ F++VFEQ F SNINY YQIW+KG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

14) VS_1884 in NC_011753


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score =  162 bits (598),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 93/157 (60%), Positives = 127/157 (81%), Gaps = 0/157 (0%)

Query  27   LKLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKLPNRKYA  86
            +K+SLMAA A NGVIG G +IPW  KGEQLLFKA+T+NQWLL+GRKTFESMG LPNRKYA
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA  60

Query  87   VISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTihiskihk  146
            V++RS+ T+++ +++ F S+E+A+  L  +T+H +VSGGG+IY+  +    T+HIS I+ 
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  147  hisGDIFFPELPRDLTLVFEQRFSSNIDYTYQIWQKG  183
            +  GD+FFP++P  + +VFEQ+FSSNI+Y YQIWQKG
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQHFSSNINYCYQIWQKG  157

15) Kfla_5968 in NC_013729


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 89.1 bits (319),  Expect = 1e-19, Method: Compositional matrix adjust.
 Identities = 59/136 (44%), Positives = 90/136 (67%), Gaps = 6/136 (4%)

Query  1    MSVVLIAAVGRNGVIGRDNELPWRIREDLQHFKALTLGHTLVMGRKTYDSIGRPLPGRRT  60
            M V L+AA ++NGVIG + ++PW  + +   FKALT  + L++GRKT++S+G +LP R+ 
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKY  59

Query  61   VVVTRQPDWSA--PGVEVAHSLAAAL-ELAD-GKDVYVAGGGEIYRQALPSADRLELTEV  116
             VVTR + W+A    V V  S+  A+  LA+   +V V+GGGEIYR++LP A  L+++ +
Sbjct  60   AVVTR-SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTI  118

Query  117  DQSPAGDVTFPAVDRS  132
            D  P GDV FP +  +
Sbjct  119  DIEPEGDVFFPNIPNT  134

16) Noca_2312 in NC_008699


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 87.6 bits (313),  Expect = 4e-19, Method: Compositional matrix adjust.
 Identities = 58/132 (44%), Positives = 91/132 (69%), Gaps = 4/132 (3%)

Query  6    KRVVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTT  65
             +V L+AA A+NGVIG GP+IPW   GEQ LFK+LT  + L++GR T++S+G +LP R  
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKY  59

Query  66   IVLTRSPDWSAEGvhvahdlpaalal--adTLEGEVMVAGGGQVYAAALPVADEQVLSEV  123
             V+TRS+ W+A+  +V    +   A+     L ++V+V+GGG++Y  +LP+A    +S +
Sbjct  60   AVVTRSA-WTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTI  118

Query  124  DLEPQGDAFYPE  135
            D+EP+GD F+P+
Sbjct  119  DIEPEGDVFFPN  130

17) Intca_2184 in NC_014830


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 84.2 bits (300),  Expect = 4e-18, Method: Compositional matrix adjust.
 Identities = 54/131 (42%), Positives = 89/131 (68%), Gaps = 4/131 (3%)

Query  3    NVTMIAAVGRNGVIGDGSTMLWHIPEDLKFFKRTTMGHPMIMGRRTFETMGVLPGRRSIV  62
            +V+++AA ++NGVIG G+ + W    +  +FK  T  + +++GR+TFE+MG LP R+  V
Sbjct  2    KVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAV  61

Query  63   VTRQPDWA--HPGVETAHSLAEAL-SLAGPADEVFIVGGGEVYREAMPYAARLVITEVDQ  119
            VTR + W+  +  V    S+ EA+ +LA  +D+V++ GGGE+YRE++P A+ L I+ +D 
Sbjct  62   VTR-SAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  120  APDGSVTFPEI  130
             P+G V FP+I
Sbjct  121  EPEGDVFFPNI  131

18) UMN179_01397 in NC_015460


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 78.1 bits (277),  Expect = 3e-16, Method: Compositional matrix adjust.
 Identities = 53/130 (41%), Positives = 88/130 (68%), Gaps = 4/130 (3%)

Query  2    LSLIVAMSKNRVIGRDNQMPWHLPADLAWFKKNTLGKPVIMGRKTFQSIGRALPNRKNIV  61
            +SL+ A +KN VIG + ++PW   ++   FK  T  + +++GRKTF+S+G ALPNRK  V
Sbjct  3    VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV  61

Query  62   LSRQGFQADGIEVV--SDLSQAL-ALIKGENEVMVIGGGHLFAETLPIADRLYLTEIDAE  118
            ++R +  AD  +V+  + + +A+ +L    ++V+V GGG+++ ETLP+A  L ++ ID E
Sbjct  62   VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE  121

Query  119  LQGDTFFPEI  128
             +GD FFP+I
Sbjct  122  PEGDVFFPNI  131

19) folA in NC_015635


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 76.8 bits (272),  Expect = 6e-16, Method: Compositional matrix adjust.
 Identities = 59/142 (42%), Positives = 89/142 (63%), Gaps = 9/142 (6%)

Query  4    IAAVARNGVIGAGNDIPWRIKEDWARFKAITMGHVLIMGRKTYDSIGRPLPGRTTIVVTR  63
            +AA A+NGVIG G +IPW  K +   FKA+T  + L++GRKT++S+G +LP R   VVTR
Sbjct  6    MAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTR  64

Query  64   DPDWTA--DGIRTAHNLDDAFEVAYALA--PEKVFVAGGGQIYAAAWDRLDVLEITEVDI  119
             + WTA  D +    ++++A    Y+LA   + V+V+GGG+IY  +      L+I+ +DI
Sbjct  65   SA-WTADNDNVIVFPSIEEA---MYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  120  EPAGEVRFPLIGPEWVVVSREQ  141
            EP G+V FP I     VV  ++
Sbjct  121  EPEGDVFFPNIPNTFEVVFEQH  142

20) Mpop_2781 in NC_010725


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 75.2 bits (266),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 54/129 (42%), Positives = 86/129 (67%), Gaps = 4/129 (3%)

Query  5    RVSLIAAVARNGVIGRDNDLVWRISSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSL  64
            +VSL+AA A+NGVIG + ++ W   ++   FKALT  + +L+GRKT +S+G +LP R+  
Sbjct  2    KVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYA  60

Query  65   VLTRD-RALTLSDVTIVHDWDEALAAAG--GDELMVVGGAEIYRLALPHADRLHLTEVDA  121
            V+TR  ++    +V +    +EA+ + +   D+++V GG+EIYR +LP A  LH++ +D 
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  122  APEGDVHFP  130
             PEGDV FP
Sbjct  121  EPEGDVFFP  129

21) Tbd_2039 in NC_007404


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 75.2 bits (266),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 54/130 (42%), Positives = 88/130 (68%), Gaps = 3/130 (2%)

Query  8    RVSVIAALAKNRVIGIENRLPWRLPEDLAHFKALTLDHPVLMGRKTFESLGRPLPRRTNV  67
            +VS++AA AKN VIG   ++PW    +   FKALT ++ +L+GRKTFES+G +LP R   
Sbjct  2    KVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYA  60

Query  68   VITRNA-DYRPDGCLVAASMPAAI-ALCQGADEIFFIGGAELYAQAIPLADRLYLTEVDA  125
            V+TR+A     D  +V +S+  A+ +L + +D+++  GG+E+Y +++P+A  L ++ +D 
Sbjct  61   VVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  126  EPEGDAWFPE  135
            EPEGD  FP+
Sbjct  121  EPEGDVFFPN  130

22) KPHS_p300720 in NC_016839


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 75.0 bits (265),  Expect = 2e-15, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 90/134 (68%), Gaps = 2/134 (1%)

Query  6    VRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHT  65
            +++ L+AA + N VIG GP+IPW   GEQ +F+ LT  + +++GRKTFES+G +LPNR  
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKY  59

Query  66   LVISRQANYRATGCVVV-STLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFLSEVH  124
             V++R A     + V+V +++ +A+   +EL +++ V+GG+EIY  +LP A  + +S ++
Sbjct  60   AVVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTID  119

Query  125  QTFEGDAFFPMLNE  138
               EGD FFP + +
Sbjct  120  IEPEGDVFFPNIPN  133

23) Ccel_1310 in NC_011898


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 73.6 bits (260),  Expect = 6e-15, Method: Compositional matrix adjust.
 Identities = 54/130 (42%), Positives = 85/130 (66%), Gaps = 4/130 (3%)

Query  2    ISMIWAMGRNNALGCKNRMPWYIPADFAYFKKVTMGKPVIMGRKTFESIGKPLPGRKNIV  61
            +S++ A ++N  +GC  ++PW   ++   FK +T  + +++GRKTFES+G +LP RK  V
Sbjct  3    VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV  61

Query  62   ITRDT-GYDPQGCIVVNSIEKAM-EYTE-EKEVFIIGGAEIYKEFLPIADRLYITLIEKE  118
            +TR +   D +  IV  SIE AM   +E   +V++ GG+EIY+E LP+A  L I+ I+ E
Sbjct  62   VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE  121

Query  119  FEADAFFPEI  128
             E+D FFP+I
Sbjct  122  PEGDVFFPNI  131

24) folA in NC_015976


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 71.5 bits (252),  Expect = 2e-14, Method: Compositional matrix adjust.
 Identities = 53/126 (43%), Positives = 82/126 (66%), Gaps = 6/126 (4%)

Query  8    IVLLLARADNGVIGSEGDIPWHIPGEQRRFKAMTMGTPMVMGRKTFDSLPRLLPGRRHIV  67
            + L+ A+A NGVIG   +IPW   GEQ  FKA+T    +++GRKTF+S+   LP R+  V
Sbjct  3    VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGA-LPNRKYAV  61

Query  68   LTRDRAWQAEGAEVV--HSVEEAI-AIAR-APVLSVIGGAEIYRLFEPVADRLEITQVGL  123
            +TR  AW A+  +V+   S+EEA+ ++A  +  + V GG+EIYR   P+A  L+I+ +++
Sbjct  62   VTRS-AWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  124  NPPGDA  129
            +P GD 
Sbjct  121  EPEGDV  126

25) folA in NC_012491


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 70.2 bits (247),  Expect = 6e-14, Method: Compositional matrix adjust.
 Identities = 53/129 (42%), Positives = 83/129 (65%), Gaps = 7/129 (5%)

Query  2    ISLIVAYARNQVIGKDGDMPWHLPADLKNVKELTTGKTIVMGRKTFESIGKPLPNRRNVV  61
            +SL+ A A+N VIG + ++PW   ++    K LT  + +++GRKTFES+G +LPNR+  V
Sbjct  3    VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV  61

Query  62   LTRSQ-DFHPEGVDVVHTKEEVL-AMGD----VIIFGGSEIYRQFLDVVDRLYITEIDLE  115
            +TRS    + + V V  + EE + ++++    VI+ GG+EIYR+ L +   L I+ ID+E
Sbjct  62   VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE  121

Query  116  TEGDTFFPA  124
             EGD FFP 
Sbjct  122  PEGDVFFPN  130

26) Runsl_2666 in NC_015703


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 68.9 bits (242),  Expect = 2e-13, Method: Compositional matrix adjust.
 Identities = 56/136 (42%), Positives = 86/136 (64%), Gaps = 6/136 (4%)

Query  1    MLLSLIVAAAQNGVIGRDNQLIWHLPDDLKQFKRLTTGHPILMGRKTFESIGKPLPNRTS  60
            M +SL+ A A+NGVIG + ++ W   ++   FK LT  + +L+GRKTFES+G +LPNR  
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKY  59

Query  61   IVITRNQHW--QFEGVMVVNSVEEAIEAARQTGTDEAFVIGGAEIYRMMLPAVDKIYLTE  118
             V+TR+  W  + + V+V  S+EEA+ +  +  TD+ +V GG+EIYR  LP    + ++ 
Sbjct  60   AVVTRSA-WTADNDNVIVFPSIEEAMYGLAEL-TDHVIVSGGGEIYRETLPMASTLHIST  117

Query  119  VKAIFEGDAFF-RIPD  133
            +    EGD FF  IP+
Sbjct  118  IDIEPEGDVFFPNIPN  133

27) RPD_3353 in NC_007958


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 67.9 bits (238),  Expect = 3e-13, Method: Compositional matrix adjust.
 Identities = 51/126 (41%), Positives = 80/126 (64%), Gaps = 7/126 (5%)

Query  21   NGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIVVTRDT-HFQ  79
            NGVIG G  IPW  K++Q  FK LT N+ +++GRKT++S+G +LP R   VVTR +   +
Sbjct  12   NGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRSAWTAD  70

Query  80   AAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTEVHASPQGD  139
               V+V PS+E A       ++   + +V+V GG+EIY + LP A+ ++++ ++  P+GD
Sbjct  71   NDNVIVFPSIEEAMY-----GLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIEPEGD  125

Query  140  TTFPAI  145
              FP I
Sbjct  126  VFFPNI  131

28) Mlg_0423 in NC_008340


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 61.3 bits (213),  Expect = 3e-11, Method: Compositional matrix adjust.
 Identities = 59/147 (41%), Positives = 91/147 (62%), Gaps = 6/147 (4%)

Query  7    ITLIAALADNGVIGRDNDLPWRIPADLKRFKARTQGRPLIMGRRNYESIGRPLPGRHNIV  66
            ++L+AA A NGVIG + ++PW   ++   FKA T  + L++GR+ +ES+G +LP R   V
Sbjct  3    VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV  61

Query  67   LTRRRDWQAEGCTVVHDP---EAALAAAGDveevmviggeeiYRLFLPRADRLELTRVHT  123
            +T R  W A+   V+  P   EA  + A   ++V+V GG EIYR  LP A  L+++ ++ 
Sbjct  62   VT-RSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDI  120

Query  124  EVPGDTFFPDIDPADWQVVAEQQPPSE  150
            E  GD FFP+I P   +VV EQ+ +S+
Sbjct  121  EPEGDVFFPNI-PNTFEVVFEQHFSSN  146

29) Theco_1713 in NC_019897


> JF262176|1|G1|325301792|ADZ05803.1|Acinetobacter_baumannii_RUH875|+|80..553|dfrA1|-|trimethoprim-insensitive 
dihydrofolate 
reductase
Length=157

 Score = 60.3 bits (209),  Expect = 7e-11, Method: Compositional matrix adjust.
 Identities = 54/134 (41%), Positives = 82/134 (62%), Gaps = 9/134 (6%)

Query  1    MTITLIAAMARNRVIGQDNGLPWRLPDDLKFFMRSTLGRTVLMGRRTFESLPGGPLKNRL  60
            M ++L+AA A+N VIG +  +PW   ++  +F   T  + +L+GR+TFES+  G+L NR 
Sbjct  1    MKVSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESM--GALPNRK  58

Query  61   NVVLTRQA-DYRPDGCEVVHSVEEALSRYGDGEL----MVAGGAEVYRWFLPHADRMLLT  115
              V+TR A     D   V  S+EEA+  YG +EL    +V+GG+E+YR  LP A  + ++
Sbjct  59   YAVVTRSAWTADNDNVIVFPSIEEAM--YGLAELTDHVIVSGGGEIYRETLPMASTLHIS  116

Query  116  EVDAEVEGDARFPE  129
             +D E EGD  FP+
Sbjct  117  TIDIEPEGDVFFPN  130