PAI Gene Information


Name : splA (SAUSA300_1758)
Accession : YP_494449.1
PAI name : vSa_beta
PAI accession : NC_007793_P5
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Virulence
Product : serine protease SplA
Function : -
Note : identified by match to protein family HMM PF00089
Homologs in the searched genomes :   184 hits    ( 182 protein-level,   2 DNA-level )  
Publication :
    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus", Lancet 367 (9512), 731-739 (2006) PUBMED 16517273.

    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Direct Submission", Submitted (11-FEB-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Diep,B.A., Gill,S.R., Chang,R.F., Phan,T.H., Chen,J.H., Davidson,M.G., Lin,F., Lin,J., Carleton,H.A., Mongodin,E.F., Sensabaugh,G.F. and Perdreau-Remington,F., "Direct Submission", Submitted (30-JAN-2006) Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.


DNA sequence : 
ATGAATAAAAATGTAATGGTTAAAGGTTTAACTGCTTTAACTATTTTAACATCTCTTGGTTTTGCTGAAAATATTTCTAA
TCAGCCTCATTCAATTGCCAAAGCAGAAAAGAATGTCAAAGAAATTACCGATGCAACTAAGGAACCATACAATTCAGTGG
TAGCATTTGTGGGTGGTACTGGTGTAGTTGTTGGTAAAAATACAATCGTAACTAACAAACATATCGCTAAAAGTAATGAT
ATTTTTAAAAATAGAGTATCAGCACATCATTCGAGTAAAGGTAAAGGCGGAGGAAACTACGACGTTAAAGACATTGTAGA
ATATCCCGGAAAAGAAGACCTTGCGATAGTTCATGTTCATGAAACAAGTACAGAAGGTTTGAATTTTAATAAGAACGTTA
GTTATACAAAATTTGCAGACGGAGCAAAAGTGAAAGATAGAATTTCTGTTATTGGTTATCCAAAGGGTGCACAAACAAAA
TATAAAATGTTTGAATCGACAGGAACGATTAACCATATCAGTGGAACGTTTATGGAATTTGATGCGTATGCACAACCAGG
TAATTCAGGATCTCCTGTATTGAATTCTAAACATGAACTGATTGGTATTTTATATGCAGGTAGTGGAAAAGATGAATCTG
AAAAGAATTTCGGTGTTTATTTCACACCACAATTAAAAGAATTTATTCAAAATAATATTGAAAAATAA

Protein sequence : 
MNKNVMVKGLTALTILTSLGFAENISNQPHSIAKAEKNVKEITDATKEPYNSVVAFVGGTGVVVGKNTIVTNKHIAKSND
IFKNRVSAHHSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSYTKFADGAKVKDRISVIGYPKGAQTK
YKMFESTGTINHISGTFMEFDAYAQPGNSGSPVLNSKHELIGILYAGSGKDESEKNFGVYFTPQLKEFIQNNIEK