Name : polA (M5005_Spy_0159)
Accession : YP_281523.1
PAI name : Not named
PAI accession : NC_007297_P1
Strain : Streptococcus pyogenes A20
Virulence or Resistance: Not determined
Product : DNA polymerase I
Function : -
Note : has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
Homologs in the searched genomes : 500 hits ( 500 protein-level )
Publication :
-Porcella,S.F., "Direct Submission", Submitted (20-AUG-2004) Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
-Sumby,P., Porcella,S.F., Madrigal,A.G., Barbian,K.D., Virtaneva,K., Ricklefs,S.M., Sturdevant,D.E., Graham,M.R., Vuopio-Varkila,J., Hoe,N.P. and Musser,J.M., "Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events", J. Infect. Dis. 192 (5), 771-782 (2005) PUBMED 16088826.
-Sumby,P., Porcella,S.F., Madrigal,A.G., Barbian,K.D., Virtaneva,K., Ricklefs,S.M., Sturdevant,D.E., Graham,M.R., Vuopio-Varkila,J., Hoe,N.P. and Musser,J.M., "Direct Submission", Submitted (08-AUG-2005) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
| DNA sequence : | |
ATGGAAAACAAGAATAAATTACTATTAATTGATGGCTCCTCTGTTGCCTTTCGTGCCTTTTTTGCCCTTTACAATCAAAT
TGACCGCTTTAAAAATCATAGCGGTCTCCATACCAATGCCATTTATGGCTTTCATTTGATGCTAGACCACATGATGAAAA
GAGTCCGGCCTACTCACGTGCTGGTGGCTTTTGATGCGGGCAAAACCACCTTCCGAACAGAAATGTATGCCGATTATAAG
GCGGGTCGCGCTAAAACCCCAGATGAATTTCGTGAGCAGTTTTCTTATATTCGTGAGATGTTGACAGCCCTTGGGATTGC
TTATTATGAGTTGGAACACTACGAAGCAGACGATATTATCGGGACGCTTGATAAAATGGCGGAGCGCACAGAAGTGCCTT
TTGATGTGACCATTGTCAGTGGTGATAAAGATTTGATCCAGTTAACTGACGAAAATACCGTGGTTGAAATTTCTAAAAAA
GGGGTTGCCGAATTTGAAGAATTCACACCGGCTTACCTCATGGAAAAAATGGGCTTGACGCCAAACCAGTTTATTGACCT
CAAAGCCTTGATGGGAGATAAATCGGATAACATTCCTGGAGTGACAAAAATTGGAGAAAAAACAGGCCTTAAGCTCCTTC
ATGAATTTGGTAGTTTGGAAGGCATTTACGAGCATATTGATGGATTCAAGACCTCAAAAATGAAAGAAAACTTGATCAAT
GACCGTGACCAAGCTTTCCTATCTAAAACGCTCGCCACTATCAATACAGCATCTCCTATCACAATTGGCTTAGATGATAT
TGTCTACAATGGTCCAGATGTTGCTAGCCTCTCTCAATTTTACGATGAGATGGATTTTGTGCAACTCAAGAAAGGTCTTG
CTAGCCAGATGCCTCAAGAGCCAGTAGCTGTCATTTCCTATCAAGAAGTGACCAATGTGTCTGCTGATTTGTTTAGCGCA
GAAGACATCTTCTACTTTGAAACGCTTCGGGATAATTACCATCGTGAGGCCATCATTGGTTTTGCTTGGGGACATGGTGA
GCAGATTTACGCATCCACAGACCTTAGCCTATTAGCGACGGATAGTTTTAAGCAGGTCTTCCAAAAACCCATTGCCACTT
ATGATTTTAAACGTAGCAAGGTCTTGTTGAGCCACTTAGGAATTGAGTTGGTAGCACCTAGCTATGATGCTAGACTAGCT
AATTACCTTCTGTCAACTGTAGAAGACAATGAGCTTAGCACCATTGCCCGCATTTTTACTGACATCTCTTTGGAAGAAGA
CGATACGGTCTATGGTAAAGGTGCTAAACGGGCTGTTCCTGATAAAGACGTCTTACTAGAACACTTAGCTCGTAAGGTCA
AAGTATTATTAGATAGCAAGTCTCAAATGCTAGACAAGCTCACTGCCCATGAGCAACTAGACCTCTATCAGAATATTGAA
TTGCCTTTGGCTAATGTCCTTGCTAAAATGGAAATTGAAGGGATCAAGGTTAATAGGGCGACTTTGCAAGATATGGCAGA
GCAAAACAAGGTCATTATTGAAGCGCTCACCCAAGAGATTTATGATATGGCTGGCCAAGAATTTAACATTAATTCGCCTA
AACAGCTGGGCAGTATCTTGTTTGAGAAGATGCAACTACCTCTTGAGATGACTAAGAAGACCAAAACAGGTTATTCTACA
GCTGTTGATGTTTTGGAACGTTTGGCACCGATTGCTCCAATTGTGGCTAAAATTTTGGATTACCGCCAGATTACTAAATT
GCAATCCACCTATGTGATTGGTTTACAGGATTATATTCTGGCTGATGGCAAGATTCATACCCGCTATGTGCAGGATCTCA
CCCAGACAGGGCGTTTGTCTAGTGTGGACCCTAATCTTCAAAACATTCCCATTCGTTTGGAACAGGGGCGTTTGATTCGT
AAGGCCTTTACCCCATCTCATGAAGATGCCGTCTTGTTGAGTTCAGATTACTCACAGATTGAATTGCGCGTGCTAGCACA
TATTTCAGGGGATGAGCATTTGATTGCTGCCTTTAATGAAGGGGCAGACATTCATACCTCAACGGCTATGCGTGTGTTTG
GGATTGACAAGGCAGCAGATGTTACTGCCAATGACCGCCGTAATGCCAAGGCTGTTAACTTTGGAATTGTGTATGGGATT
TCTGATTTTGGTTTGTCAAATAACCTTGGTATCACCCGTAAACAGTCCAAGTCTTACATTGATACCTATTTTGAACGCTA
TCCTGGGATTAAAGCCTATATGGAAAATGTGGTGCGTGAGGCTAAAGACAAGGGCTATGTAGAGACCCTCTTTAAGCGTC
GCCGTGAATTACCGGATATCAACTCTCGTAATTTCAACGTTCGCTCTTTTGCGGAGCGTACAGCCATCAACTCGCCCATT
CAAGGAAGCGCAGCTGATATTCTCAAAATCGCTATGATTAATCTGGATAAGGCCTTGCAAGCAGGTGGTTTTAGAGCTAA
AATGCTGCTTCAAGTGCATGATGAAATCGTTTTGGAAGTGCCAAATGATGAGTTGACTGCTATAAAAAAACTTGTCAAAG
ACACCATGGAAGCTGCTGTTGATTTAGCTGTTCCTTTATGTGTCGATGAAAGTACTGGGCAGAGCTGGTACGAAGCCAAA
TAA
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| Protein sequence : | |
MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHVLVAFDAGKTTFRTEMYADYK
AGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK
GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN
DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAVISYQEVTNVSADLFSA
EDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA
NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE
LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST
AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIR
KAFTPSHEDAVLLSSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI
SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI
QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK
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