Name : leuS (M5005_Spy_0147)
Accession : YP_281511.2
PAI name : Not named
PAI accession : NC_007297_P1
Strain : Streptococcus pyogenes A20
Virulence or Resistance: Not determined
Product : leucyl-tRNA synthetase
Function : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl
Homologs in the searched genomes : 1808 hits ( 1808 protein-level )
Publication :
-Porcella,S.F., "Direct Submission", Submitted (20-AUG-2004) Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
-Sumby,P., Porcella,S.F., Madrigal,A.G., Barbian,K.D., Virtaneva,K., Ricklefs,S.M., Sturdevant,D.E., Graham,M.R., Vuopio-Varkila,J., Hoe,N.P. and Musser,J.M., "Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events", J. Infect. Dis. 192 (5), 771-782 (2005) PUBMED 16088826.
-Sumby,P., Porcella,S.F., Madrigal,A.G., Barbian,K.D., Virtaneva,K., Ricklefs,S.M., Sturdevant,D.E., Graham,M.R., Vuopio-Varkila,J., Hoe,N.P. and Musser,J.M., "Direct Submission", Submitted (08-AUG-2005) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
| DNA sequence : | |
ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCACACCTTTAAAACAGGAAC
AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATATCCATCAGGAGCTGGTCTCCACGTTGGTCACCCAG
AAGGCTATACAGCAACTGATATTCTTAGCCGTTTCAAACGTGCCCAAGGTCACAATGTCCTCCACCCAATGGGTTGGGAT
GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGATCCAGCCGAGTTTACAGCTGAAAACATCGCTAA
CTTCAAACGCCAGATTAATGCTCTTGGCTTCTCATACGACTGGGACCGTGAAGTTAACACAACTGACCCTAACTACTACA
AGTGGACGCAGTGGATCTTTACCAAGCTTTATGAAAAAGGTCTAGCCTACGAAGCTGAAGTTCCCGTTAACTGGGTTGAA
GAATTGGGAACAGCTATCGCCAACGAAGAGGTTCTTCCAGATGGGACATCAGAACGTGGCGGCTATCCAGTTGTCAGAAA
ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACTTGGAAGAAGTTGACTGGCCAG
AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGCGCTAATGTAACCTTCAAGGTTAAGGATACAGAT
AAGGACTTCACTGTCTTTACAACACGTCCTGACACGCTTTTTGGTGCAACTTACGCCGTTCTTGCTCCTGAGCATGCCTT
GGTTGATGCTATTACGACATCTGACCAGGCAGAAGCCGTGGCTGACTACAAACGTCAAGCAAGTCTCAAATCAGACCTTG
CTCGTACAGACCTTGCCAAAGAAAAAACTGGTGTCTGGACGGGTAGCTATGCGATTAACCCGGTCAACGGCAAAGAAATG
CCAGTTTGGATTGCGGACTATGTCCTTGCTAGCTACGGTACTGGTGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA
CTGGGAATTCGCAAAACAATTTAACCTAGACATCATCCCTGTTCTTGAAGGTGGTAATGTTGAAGAGGCTGCCTTTACAG
AAGACGGTCTTCACATCAACTCCGACTTCCTAGATGGTCTTGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT
GAAGCAGAAGGCGTCGGTAATGAAAATGTCACTTACCGTCTCCGTGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA
GCCAATCCCAATCATCCACTGGGAAGATGGGACATCAACAGCGGTTCCTGAGAGTGAATTGCCATTGGTTCTTCCAGTAA
CTAAGGATATTCGTCCTTCAGGTACTGGTGAGAGCCCGCTTGCTAACGTGACAGACTGGTTGGAAGTTACCCGTGAAGAT
GGTGTTAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTATTATCTTCGTTACATCGATCC
ACACAACACCGAAAAACTGGCTGATGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC
ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTTGTACCTACCAAAGAGCCA
TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGGACAAGCTACCGCGATAGCCGTGGAGCGCTTGTAGCGACTGACAA
GGTTGAAAAACGTGATGGCAGCTTCTTCCATGTGGAAACTGGGGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT
CACTTAAGAACGTCGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACCCTTCGTGTTTACGAGATGTTCATG
GGACCACTTGACGCTTCCATCGCTTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT
GATCACGACTAAAGAGATCACTGAGGAAAATAGCGGAGCCCTTGACAAGGTTTACAACGAAACCGTTAAGGCCGTTACTG
AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA
CTCTTTAGCGACTATGCCAAAGGCTTTGTTCAATTGATTGCACCATTTGCACCGCACTTAGGTGAGGAACTCTGGCAAGC
CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATGAAAGCAAATTGGTTGAAAACGATGTGG
AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTAGTTGCTAAAGACCTTTCACGCGAAGAATTACAAGAA
GTTGCCCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT
CGTTAATATTGTTATCAAATAG
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| Protein sequence : | |
MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWD
AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD
KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTSDQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGKEM
PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKASAIAKMVEWL
EAEGVGNENVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED
GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP
FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM
GPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK
LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE
VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK
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