PAI Gene Information


Name : splC (SAR1906)
Accession : YP_041284.1
PAI name : vSa_beta
PAI accession : NC_002952_P3
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Virulence
Product : serine protease
Function : -
Note : Similar to Staphylococcus aureus serine protease SplC TR:Q9KH49 (EMBL:AF271715) (239 aa) fasta scores: E(): 7.6e-83, 94.56% id in 239 aa
Homologs in the searched genomes :   182 hits    ( 182 protein-level )  
Publication :
    -Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.


DNA sequence :
TTAGTCATTAAAAGCATGGCAGCATTAGCCATTTTAACATCAGTAACTGGAATAAGTGCTGCAGTCGTTGAAGAGACACA
ACAAATAGCAAAAGCAGAGAAGCATGTTACGCAAGTTAAAGATACAAATGTTTTTCCGTATCATGGCGTCGTTGCATTTA
AAGATGCGACAGGCTTTGTAATCGGTAAAAATACAATTATCACTAATAAACATGTATCAAAGGATTATAAAGTTGGCGAT
AGAATTACTGCTCATCCAAATGGTGACAAAGGAAATGGTGGTATTTATAAAATTAAAAGTATTTCCGATTATCCAGGCAA
TGAAGATATTTCCGTCATGAATATAGAAGAACAAGCGGTTGAACGTGGATCCAATGGCTTTAATTTTAATGATAATGTTC
AAGCATTTAAATTTGCAAAAGATGCTAAAGTTGATGACAAAATTAAAGTTATCGGTTACCCGTTACCTGCACAAAACAGT
TTTAAACAATTTGAATCTACAGGAACTATAAAACGAATTAAAGACAATATTTTAAATTTTGATGCATATATCGAACCAGG
TAATTCAGGATCACCCGTTCTAAATTCTAACAATGAAGTCATAGGTGTTGTATATGGCGGCATTGGAAAAGTTGGTTCTG
AATACAATGGTGCTGTATATTTTACGCCTCAAATTAAAGATTTTATTCAAAAGCACATTGAACAATAA

Protein sequence :
MNKNLVIKSMAALAILTSVTGISAAVVEETQQIAKAEKHVTQVKDTNVFPYHGVVAFKDATGFVIGKNTIITNKHVSKDY
KVGDRITAHPNGDKGNGGIYKIKSISDYPGNEDISVMNIEEQAVERGSNGFNFNDNVQAFKFAKDAKVDDKIKVIGYPLP
AQNSFKQFESTGTIKRIKDNILNFDAYIEPGNSGSPVLNSNNEVIGVVYGGIGKVGSEYNGAVYFTPQIKDFIQKHIEQ