Name : hysA1 (SAR1892)
Accession : YP_041274.1
PAI name : vSa_beta
PAI accession : NC_002952_P3
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Virulence
Product : hyaluronate lyase precursor 1
Function : -
Note : Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 75.8% id in 810 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(
Homologs in the searched genomes : 58 hits ( 58 protein-level )
Publication :
-Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.
-Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.
-Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
-Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.
| DNA sequence : | |
ATGACAAATAAAATGAAGAAATGGCAAAAATTATCCACCATTACGTTATTAATGACCGGAGTGATTGCTTTAAATAATGG
TGAATTTAGAAATGTTGATAAACATCAAATCGCTGTGGCTGATACGAATGTTCAAACGCCAGATTATGAAAAATTGAAGA
AGACGTGGCTCGACGTTAACTACGGTTATGATCAGTATGATGAGAATAATCAAGATATGAAGAAGAAGTTTGATGCTAAA
GAAAAAGAAGCCAAGAAGTTACTTGATGACATGAAAACTGATACGAATAGAACATATTTGTGGTCAGGAGCTGAAAACCT
TGAAACTAATTCTTCTCACATGACAAAAACCTATCGTAATATCGAGAAAATCGCAGAATCAATGCAACATAAGAATACGG
TATTAAAAACAGTTGAAAACAAGTTGAAAATAAAAGAAGCCCTAGATTGGATGCACAAAAATGTTTATGGCAAGAATCCT
TCTCAAAAAGTCGAGGATTTAACTAAAAATCGTAAGGGGCAAACTACACCCAAGAATAACTCATTGAATTGGTGGGATTA
TGAAATTGGTACGCCAAGAGCATTAACAAATACACTACTTCTAATGGATGATATGCTCACTAAAGATGAAATGAAAAATT
ATTCAAAACCTATTAGTACATATGCACCATCCAGTGACAAAATTTTATCTTCTGTTGGTGAATCAGAAGATGCTAAAGGT
GGAAATTTAGTGGACATTTCTAAAGTAAAACTTTTAGAAAGTGTTATTGAAGAAGATGTAGATATGTTGAAAAAGTCTAT
AGATTCTTTTAATAAAGTGTTCACTTATGTTCAAGATTCTGCCACTGGTAAAGGTCGCAATGGATTCTATAAAGATGGCT
CTTACATTGATCATCAAGATGTCCCTTACACTGGTGCTTATGGTGTTGTACTATTAGAGGGTATTTCTCAAATGATGCCG
ATGATAAAAGAATCTCCTTTTAAAACTACACAAGATAATGCTACATTAAGCAATTGGATTGACGAAGGGTTTATGCCATT
AATCTATAAAGGTGAAATGATGGATTTATCACGAGGTAGAGCTATCAGTCGTGAAAATGAAACGAGTCATACAGCGTCAG
CGACTGTAATGAAATCATTGTTGAGATTGAATGATACCATGGATGATTCAACAAAAACTAGATATAAGCAAATCGTTAAA
ACTTCTGTTAATTCTGATTCAAGTTACAACCAAAATAATTATTTAAATTCATATTCAGACATAGCTAAAATGAAAAAGTT
AATGAATGATAGTACTATTTCTAAAAACGATTTAACACAGCAACTTAAAATATATAATGACATGGATCGTGTCACCTATC
ACAATAAAGACCTGGACTTTGCATTTGGTTTAAGTATGACATCGAAAAACATCGCACGATACGAAAATATCAACGGAGAG
AACTTAAAAGGTTGGCACACCGGTGCAGGCATGTCTTATTTATATAACAGCGATGTCAAACACTATCGCGATAACTTCTG
GGCAACAGCCGATATGACTTGTCTTCCAGGCACTACTACTTTAAATGATATGCCATCTACTAATACTAAGAATGATAAAT
CTTTTGTTGGCGGGACAAAATTAAATAATAAATACGCAAGCATCGGTATGGATTTTGAAAATCAGGACAAAACTTTAACT
GCCAAAAAATCATATTTCATATTAAACGATAAAATTGTCTTCTTAGGAACTGGCATTAAAAGTACTGATTCATCAAAGAA
TCCAGTTACAAGTGTTGAAAATCGCAAAGCAAATGGGTATAAATTATTTAAAGATGATATTGAAATTACCACTTCAGATG
TTAATGCTCAGGAAACCCATTCAGTCTTTTTAGAGTCCAACGATACTAAAAAGAACATTGGTTATCATTTCTTAGACAAG
CCAAAAATAACTGTAAAAAAAGAAAGTCATACTGGTAAGTGGAGTGAAATTAATAAAAGTCAAAAAAAAGATGACAAAAA
AGATGAGTATTATGAAGTAACTCAAACACATAATACATCTGACAGTAAATATGCATATGTTTTGTATCCTGGTTTATCAA
AAAGTGATTTTAAATCGAAGAATAATAATGTAAGTATTGTTAAACAAGATGAAGATTTTCATGTGATAAAAGATAATGAT
GGCGTATTTGCTGGGGTTAATTATAGTGATAATACTAAATCTTTTGATATAAACGGAATTACTGTTGAATTAAAAGAAAA
AGGCATGTTTGTAATTAAAAAGAAAGATGATAAAGCATATAAATGTAGCTTCTATAATCCTGAAACTACAAATACCGCTT
CAAATATAGAATCAAAAATTTTTATTAAAGGTTACACCATAACTAATAAAAGTGTCATAAACTCTAATGATGCTGGTGTA
AACTTTGAATTAACTAAATAA
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| Protein sequence : | |
MTNKMKKWQKLSTITLLMTGVIALNNGEFRNVDKHQIAVADTNVQTPDYEKLKKTWLDVNYGYDQYDENNQDMKKKFDAK
EKEAKKLLDDMKTDTNRTYLWSGAENLETNSSHMTKTYRNIEKIAESMQHKNTVLKTVENKLKIKEALDWMHKNVYGKNP
SQKVEDLTKNRKGQTTPKNNSLNWWDYEIGTPRALTNTLLLMDDMLTKDEMKNYSKPISTYAPSSDKILSSVGESEDAKG
GNLVDISKVKLLESVIEEDVDMLKKSIDSFNKVFTYVQDSATGKGRNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMP
MIKESPFKTTQDNATLSNWIDEGFMPLIYKGEMMDLSRGRAISRENETSHTASATVMKSLLRLNDTMDDSTKTRYKQIVK
TSVNSDSSYNQNNYLNSYSDIAKMKKLMNDSTISKNDLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNIARYENINGE
NLKGWHTGAGMSYLYNSDVKHYRDNFWATADMTCLPGTTTLNDMPSTNTKNDKSFVGGTKLNNKYASIGMDFENQDKTLT
AKKSYFILNDKIVFLGTGIKSTDSSKNPVTSVENRKANGYKLFKDDIEITTSDVNAQETHSVFLESNDTKKNIGYHFLDK
PKITVKKESHTGKWSEINKSQKKDDKKDEYYEVTQTHNTSDSKYAYVLYPGLSKSDFKSKNNNVSIVKQDEDFHVIKDND
GVFAGVNYSDNTKSFDINGITVELKEKGMFVIKKKDDKAYKCSFYNPETTNTASNIESKIFIKGYTITNKSVINSNDAGV
NFELTK
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