PAI Gene Information


Name : SAR0459 (SAR0459)
Accession : YP_039908.1
PAI name : vSa_alpha
PAI accession : NC_002952_P2
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Not determined
Product : pyridoxal-phosphate dependent protein
Function : -
Note : Similar to Bacillus subtilis cysteine synthase YrhA TR:O05393 (EMBL:U93874) (307 aa) fasta scores: E(): 2.4e-51, 51.864% id in 295 aa, and to Helicobacter pylori cysteine synthase HP0107 SW:CYSM_HELPY (P56067) (306 aa) fasta scores: E(): 4.7e-47, 48.993%
Homologs in the searched genomes :   425 hits    ( 425 protein-level )  
Publication :
    -Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.


DNA sequence :
ATGATTACTTATGATTTAATTGGCAATACACCATTAGTACTGTTAGAACATTATAGTGATGATAAAGTTAAAATTTATGC
CAAGCTTGAACAATGGAATCCTGGAGGCAGTGTTAAAGACAGACTCGGGAAATATTTAGTAGAGATGGCAATTCAAGAAG
GGCGTGTGCGTGCAGGTCAAACTATTGTTGAAGCGACTGCTGGCAATACAGGCATAGGGTTAGCTATTGCAGCAAATAGA
CATCATTTGAAATGTAAGATCTTTGCGCCGTATGGTTTTTCAGAAGAAAAGATTAATATTATGATAGCGCTTGGTGCAGA
TGTTTCAAGAACGAGTCAGTCTGAAGGTATGCATGGGGCACAATTAGCTGCACGTTCATATGCTGAAAAATATGGTGCCG
TTTATATGAATCAATTTGAATCCGAACATAATCCGGATACATATTTTCATACATTGGGACCCGAATTGACTTCAGCATTA
CAGCATATTGATTATTTTGTGGCTGGTATTGGCTCTGGCGGTACATATACAGGTACCGCACGTTATTTAAAGCAACATCA
CGTGCAATGTTATGCCGTTGAGCCAGAAGGGTCCGTGTTAAATGGAGGGCCAGCTCATGCACATGACACTGAAGGTATCG
GTTCTGAGAAATGGCCGATATTTTTAGAGAGAAGTCTTGTAGATGGGATATTTACGATTAAAGATCAAGATGCCTTTCGA
AATGTCAAAAGTTTGGCAAAGCATGAAGGATTATTGGTAGGCAGTTCTTCAGGTGCAGCATTACAAGGTGCATTGAATTT
AAAAGCGCAATTATCTGAAGGTACGATTGTTGTCGTATTTCCAGATGGTAGCGATCGATATATGTCTAAGGAAATATTTA
ATTATGAGGAGAATGATTATGAATAA

Protein sequence :
MITYDLIGNTPLVLLEHYSDDKVKIYAKLEQWNPGGSVKDRLGKYLVEMAIQEGRVRAGQTIVEATAGNTGIGLAIAANR
HHLKCKIFAPYGFSEEKINIMIALGADVSRTSQSEGMHGAQLAARSYAEKYGAVYMNQFESEHNPDTYFHTLGPELTSAL
QHIDYFVAGIGSGGTYTGTARYLKQHHVQCYAVEPEGSVLNGGPAHAHDTEGIGSEKWPIFLERSLVDGIFTIKDQDAFR
NVKSLAKHEGLLVGSSSGAALQGALNLKAQLSEGTIVVVFPDGSDRYMSKEIFNYEENDYE