PAI Gene Information


Name : SAR0458 (SAR0458)
Accession : YP_039907.1
PAI name : vSa_alpha
PAI accession : NC_002952_P2
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Not determined
Product : sodium:neurotransmitter symporter family protein
Function : -
Note : Similar to Bacillus subtilis transporter YocR TR:O34383 (EMBL:AF027868) (445 aa) fasta scores: E(): 1.8e-73, 49.103% id in 446 aa, and to Bacillus halodurans sodium-dependent transporter BH0217 TR:Q9KG95 (EMBL:AP001507) (457 aa) fasta scores: E(): 1.1e-67
Homologs in the searched genomes :   321 hits    ( 321 protein-level )  
Publication :
    -Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.


DNA sequence : 
ATGATGAAAAGACAACAATCACAATGGAAGTCATCAACTGGATTTATTTTAGCTAGTGCGGGTTCTGCAATCGGTCTTGG
TGCCATGTGGAAATTCCCATATATGGCAGGGATCTATGGCGGCGGTGCCTTTCTAGCTATGTTCTTAATATTCACCATTT
TTGTTGGATTACCATTACTCATTATGGAATTCACTGTTGGGAAAATGGGACGGACATATACAACACAAATATATAGTAAA
TTAACTGGTAAAAAATGGCTCAATATCATTGGCTGGAACGGTAATTTGGCAGTGTTTATTTTATTTGGCTTCTATAGTGT
TATTGGTGGTTGGATTGTCATTTACATCGGACAAGTATTATGGCAATTAGTTATATTTCAACGCATCAATCATCTCCAAG
AAATGAATTTTGAAGCGGTAATATCAAATCCTTGGTTAACCGTTCTAGGGCAAGGTATATTCATATTCGCTACGATGATT
ATTGTCATGTTAGGTGTTGAAAAGGGATTAGAAAAGGCATCGAAAGTTATGATGCCGTTGCTGTTTGTCTTTTTAATCAT
CATTGTGATTAAGTCTTTAACATTAGATGGTGCCTTAGAAGGTGTGAAATTTATTTTACAACCAAGAGTGTCAGAGATTA
CTGCTGATGGAATCTTGTTTGCGCTAGGTCAATCATTCTTTACGTTATCATTAGGAACTACAGGTATGATTACTTATGCG
AGTTATGCCTCTAAAGACATGACGATTAAGTCATCAGCTATTTCTATCGTTGTTATGAATATCTTTGTATCTGTATTGGC
AGGCCTAGCTATATTTCCGGCGTTACATAGTTTTGGCTATGAGCCACAAGAAGGGCCTGGATTATTATTTAAAGTACTGC
CAATGGTCTTTAGTCAAATGCATCTAGGCACATTATTCTATTTGGGATTCTTAGTGCTGTTCTTATTTGCGGCTTTAACG
TCATCTATTTCTTTATTAGAATTAAATGTTTCTAACTTCACGAAGAATGACAATACAAAACGTAAAAAAGTCGCAGTGAT
CGGTAGTATATTAGTATTTATCATTAGTATTCCAGCAACCTTATCTTTTGGTATCTTAAAAGATGTAAGATTCGGTGCGG
GAACGATTTTTGATAATATGGATTTCATCGTTTCGAATGTATTGATGCCATTAGGCGCATTAGGTACTACGCTTGTCGTA
GGACAATTATTAGATAAAAAGTTATTACAACAATATTTTGGTAAAGATCGATTTAGATTATTCAGTGGTTGGTATTACTT
AATTAAGTATGCGATGCCTGTCGTTATTATTTTAGTCTTTATCGTGCAATTATTTAGTTAA

Protein sequence : 
MMKRQQSQWKSSTGFILASAGSAIGLGAMWKFPYMAGIYGGGAFLAMFLIFTIFVGLPLLIMEFTVGKMGRTYTTQIYSK
LTGKKWLNIIGWNGNLAVFILFGFYSVIGGWIVIYIGQVLWQLVIFQRINHLQEMNFEAVISNPWLTVLGQGIFIFATMI
IVMLGVEKGLEKASKVMMPLLFVFLIIIVIKSLTLDGALEGVKFILQPRVSEITADGILFALGQSFFTLSLGTTGMITYA
SYASKDMTIKSSAISIVVMNIFVSVLAGLAIFPALHSFGYEPQEGPGLLFKVLPMVFSQMHLGTLFYLGFLVLFLFAALT
SSISLLELNVSNFTKNDNTKRKKVAVIGSILVFIISIPATLSFGILKDVRFGAGTIFDNMDFIVSNVLMPLGALGTTLVV
GQLLDKKLLQQYFGKDRFRLFSGWYYLIKYAMPVVIILVFIVQLFS