PAI Gene Information


Name : SAR0453 (SAR0453)
Accession : YP_039901.1
PAI name : vSa_alpha
PAI accession : NC_002952_P2
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Not determined
Product : hypothetical protein
Function : -
Note : Similar to Aquifex aeolicus hypothetical protein AG_863 TR:O67026 (EMBL:AE000711) (1007 aa) fasta scores: E(): 2.9e-42, 27.685% id in 1015 aa, and an internal region of Bacillus subtilis hypothetical protein YbcD TR:O87092 (EMBL:AB006424) (686 aa) fasta s
Homologs in the searched genomes :   104 hits    ( 104 protein-level )  
Publication :
    -Holden,M.T.G., "Direct Submission", Submitted (23-JUN-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: mh3@sanger.ac.uk.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance", Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9786-9791 (2004) PUBMED 15213324.

    -Holden,M.T.G., Feil,E.J., Lindsay,J.A., Peacock,S.J., Day,N.P.J., Enright,M.C., Foster,T.J., Moore,C.E., Hurst,L., Atkin,R., Barron,A., Bason,N., Bentley,S.D., Chillingworth,C., Chillingworth,T., Churcher,C., Clark,L., Corton,C., Cronin,A., Doggett,J., Do, "Direct Submission", Submitted (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Kenny,J.G., Ward,D., Josefsson,E., Jonsson,I.M., Hinds,J., Rees,H.H., Lindsay,J.A., Tarkowski,A. and Horsburgh,M.J., "The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications", PLoS ONE 4 (2), E4344 (2009) PUBMED 19183815 REMARK Publication Status: Online-Only.


DNA sequence : 
ATGACAACACAGTTAAATATCAATTCAGTCATTGAAAATGCGAAACGTGTTATTACACCATTATCACCGATTTCGATTTT
TGCAGCACGAAATCCATGGGAAGGATTAGAAGCGGATACGTTTGAAGATGTCGCAAAATGGTTACGTGATGTTCGCGATG
TGGATATTTTCCCAAATAAAGCATTAATAGAAAGTGCTGTGGCACGCGGTGAATTAGACGAAAGTGTCTTTAATCAACTT
GTTACTGATATGCTACTTGAACATCACTACAATATCCCGCAACACTACATCAATCTTTATATTGATAACATTAAAACATT
AAAAGACGTACCTGCATCATACATGAATCATTCAAATGTTGATGTTGTTGCTGATCTACTATTAGAAAAATCAAAACGTG
ATATGGCTGAATCATATCATCACTATGATGTACGTCCGATGAGTGATGCAATAATAGATGAACAAGGTGAGCCACTTAGC
GAACAAGTGAATCGTCAAATGATTAAATGGACGAAACTTTATATCGATCAATTTCTATCGAGTTGGACAATGCCGAAGCG
TGAGCAAAGTTTTTACCATGCATGGTTGCATTTAGCGCAACATGACCATAGTTTTACTAAAGCACAGCGCCAAGTGATTA
AAGGCTTACCCAATGATCCTAAAATGACGATAGAGTCAGTATTAAATCATTTTTCAATAGCGCAGGAAGACTACCAAGCT
TATGTTGAAGGACATCTTTTGGCGTTACCGGGTTGGGCAGGTATATTATACTACCGCTCACAACAGCATCACTTTGAACA
ACATTTGTTAACGGATTATTTGGCCATTCGGTTAGTTGTCGAACAATTGCTAGTTGGTGATGAGTTTAAGTCAGTCACTA
AAGATTGTGAAAGCAGATCGGAAAATTGGTTTAAGCAAACTGTTGCATCATGGTGTTACTACAGTGATATGCCTAGCGAT
GTATTACTACAACATGACGTCAATGAAATTCAAACGTTTATTCATTTTGCAGCAACTATGAATAAAAATGTATTTAAAAA
TTTATGGTTGATTGCCTGGGAAATGACATACGAATCTCAGTTAAAACAAAAAATTAAAGCAGGTCATGAAAGTGTGGCGG
GCGCATTAGATGTAAACCAAGTAAATGTTACTGAAAATGACAACGCTAATCAGTCACATTCAGTATCGTTAAATGCCACA
CAAGCAGTTGATGAAAATAATAGCGAGCTAAATCAGGTGGGCACATCAACGAAAGCGCAAATTGCATTTTGTATAGATGT
TCGTTCAGAACCATTTCGTAGACATATCGAAGCAGCAGGGCCCTTTGAAACGATTGGTATTGCAGGTTTTTTTGGATTAC
CTATTCAAAAAGATGCCGTAGACGAACAATTCAAACATGATTCATTACCTGTCATGGTACCGCCGGCATATCGCATTAAA
GAATTTGCAGACCGCTACGATATGAATGTTTATCGACAACAGCAACAGACAATGTCATCGATGTTTTACACATTTAAATT
GATGAAAAATAATGTTATGCCTAGTCTGTTATTGCCTGAATTAAGTGGGCCATTTTTAAGCTTGAGTACCATTGTCAATT
CGATTATGCCTAGAAAAAGTCGCGTGTCTTTACAAAAAATAAAACAAAAATGGTTAAAAAAGCCTGAAACAAAGTTAACG
ATTGATCGTGAGTTTGACAGAACATCAGACTTACCTGTTGGATTTACTGAACAAGAGCAAATTGATTTCGCGTTACAAGC
GTTGAAATTGATGGATTTAACCGAAGCATTTGCGCCGTTCGTTGTGTTAGCAGGTCATGCTAGTCATTCTCACAATAATC
CACATCACGCATCACTTGAATGTGGGGCTTGTGGTGGTGCATCAAGCGGTTTTAATGCTAAGTTATTAGCGATGATATGT
AATCGTCCAAATGTCAGACAAGGATTAAAACAAGCAGGCGTGTATATTCCAGAGACTACTGTTTTTGCGGCAGCAGAACA
TCATACGTCTACTGATACATTGGCATGGGTATATGTGCCAGACACATTATCAGCTTTAGCTCTAGATGCATATGAATCAT
TGAATGACGTCATGCCGATGATTTCTGAACACGCGAATCGCGAACGTTTGGACAAACTGCCAACGATTGGTCGTGTGAAT
CATCCAGTGGAAGAAGCGCAGCGGTTTGCAAGTGATTGGAGTGAGGTACGTCCAGAATGGGGCTTGGCTAAAAATGCATC
ATTTATAATTGGACGACGCCAATTAACAAAAGGCATTGATTTAGAAGGGCGGACATTTTTACACAATTATGATTGGCGTA
AAGATAAAGATGGCAAATTGTTAAATACCATCATTTCTGGTCCGGCGCTTGTGGCACAATGGATTAATTTACAATATTAT
GCGTCGACAGTTGCGCCGCATTTTTACGGAAGTGGGAATAAAGCGACACAAACCGTCACGTCAGGTGTTGGTGTCATGCA
AGGTAATGCGAGTGATCTGATGTATGGCTTATCATGGCAATCTGTTATGGCTGCTGATCGAACGATGTATCATTCGCCAA
TTCGTTTGCTTGTCGTTGTTCAGGCACCCGATTTTGTTGTAGCTAGACTACTCGCGAATAATGAGCATTTCGCTAGGAAG
GTGTCTAATCATTGGCTGCGTTTAATGAGCGTTAATGAGGAAGGGCGTTTTAAAAGTTGGATTTAA

Protein sequence : 
MTTQLNINSVIENAKRVITPLSPISIFAARNPWEGLEADTFEDVAKWLRDVRDVDIFPNKALIESAVARGELDESVFNQL
VTDMLLEHHYNIPQHYINLYIDNIKTLKDVPASYMNHSNVDVVADLLLEKSKRDMAESYHHYDVRPMSDAIIDEQGEPLS
EQVNRQMIKWTKLYIDQFLSSWTMPKREQSFYHAWLHLAQHDHSFTKAQRQVIKGLPNDPKMTIESVLNHFSIAQEDYQA
YVEGHLLALPGWAGILYYRSQQHHFEQHLLTDYLAIRLVVEQLLVGDEFKSVTKDCESRSENWFKQTVASWCYYSDMPSD
VLLQHDVNEIQTFIHFAATMNKNVFKNLWLIAWEMTYESQLKQKIKAGHESVAGALDVNQVNVTENDNANQSHSVSLNAT
QAVDENNSELNQVGTSTKAQIAFCIDVRSEPFRRHIEAAGPFETIGIAGFFGLPIQKDAVDEQFKHDSLPVMVPPAYRIK
EFADRYDMNVYRQQQQTMSSMFYTFKLMKNNVMPSLLLPELSGPFLSLSTIVNSIMPRKSRVSLQKIKQKWLKKPETKLT
IDREFDRTSDLPVGFTEQEQIDFALQALKLMDLTEAFAPFVVLAGHASHSHNNPHHASLECGACGGASSGFNAKLLAMIC
NRPNVRQGLKQAGVYIPETTVFAAAEHHTSTDTLAWVYVPDTLSALALDAYESLNDVMPMISEHANRERLDKLPTIGRVN
HPVEEAQRFASDWSEVRPEWGLAKNASFIIGRRQLTKGIDLEGRTFLHNYDWRKDKDGKLLNTIISGPALVAQWINLQYY
ASTVAPHFYGSGNKATQTVTSGVGVMQGNASDLMYGLSWQSVMAADRTMYHSPIRLLVVVQAPDFVVARLLANNEHFARK
VSNHWLRLMSVNEEGRFKSWI