PAI Gene Information


Name : mecI (SARLGA251_00280)
Accession : YP_005754043.1
PAI name : Type-XI SCCmec
PAI accession : NC_017349_R1
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Resistance
Product : methicillin resistance regulatory protein MecI
Function : -
Note : Similar to Staphylococcus aureus (strain N315) meci recname: full=methicillin resistance regulatory protein meci UniProt:P68261 (EMBL:BA000018) (123 aa) fasta scores: E()=8.8e-30, 66.7% id in 123 aa
Homologs in the searched genomes :   72 hits    ( 72 protein-level )  
Publication :
    -Garcia-Alvarez,L., Holden,M.T., Lindsay,H., Webb,C.R., Brown,D.F., Curran,M.D., Walpole,E., Brooks,K., Pickard,D.J., Teale,C., Parkhill,J., Bentley,S.D., Edwards,G.F., Girvan,E.K., Kearns,A.M., Pichon,B., Hill,R.L., Larsen,A.R., Skov,R.L., Peacock,S.J., M, "Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study", Lancet Infect Dis 11 (8), 595-603 (2011) PUBMED 21641281.

    -Garcia-Alvarez,L., Holden,M.T., Lindsay,H., Webb,C.R., Brown,D.F., Curran,M.D., Walpole,E., Brooks,K., Pickard,D.J., Teale,C., Parkhill,J., Bentley,S.D., Edwards,G.F., Girvan,E.K., Kearns,A.M., Pichon,B., Hill,R.L., Larsen,A.R., Skov,R.L., Peacock,S.J., M, "Direct Submission", Submitted (05-APR-2012) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Holden,M., "Direct Submission", Submitted (02-FEB-2011) to the INSDC. Holden M., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UNITED KINGDOM.


DNA sequence : 
ATGACACGTGAAGGCTATGATATATCAGCGTCAGAATGGGAAATAATGAATACGATTTGGAATAAAAAATTAATAAGTGC
TAATGACGTTATAGAAATAGTACAAAAGCACAAGGAATGGAGTCCAAAAACAATAAGAACACTAATCAATCGTCTTTACA
AAAAGAAATTCATAGATAGAACAAGTCGAAATAAAATTTTTGAATATTTCCCAATAGTAGAGGAAAAAGATATGAAGTAC
AAAACGTCTAAAGTGTTTTTGGATAAAGTGTATGAAGGTGGATTAAATTCATTAGTCTTAAATTTTGTTGAAAATGAAGA
ATTGTCCGAAGATGATATTGAAGAATTGAAAAATATATTAAATAATAAATATTAA

Protein sequence : 
MTREGYDISASEWEIMNTIWNKKLISANDVIEIVQKHKEWSPKTIRTLINRLYKKKFIDRTSRNKIFEYFPIVEEKDMKY
KTSKVFLDKVYEGGLNSLVLNFVENEELSEDDIEELKNILNNKY