PAI Gene Information


Name : blaZ (SARLGA251_00250)
Accession : YP_005754040.1
PAI name : Type-XI SCCmec
PAI accession : NC_017349_R1
Strain : Staphylococcus aureus 04-02981
Virulence or Resistance: Resistance
Product : beta-lactamase
Function : -
Note : Similar to Staphylococcus aureus blaz recname: full=beta-lactamase ec=3.5.2.6 altname: full=penicillinase flags: precursor UniProt:P00807 (EMBL:X04121) (281 aa) fasta scores: E()=7.4e-73, 67.7% id in 279 aa
Homologs in the searched genomes :   48 hits    ( 48 protein-level )  
Publication :
    -Garcia-Alvarez,L., Holden,M.T., Lindsay,H., Webb,C.R., Brown,D.F., Curran,M.D., Walpole,E., Brooks,K., Pickard,D.J., Teale,C., Parkhill,J., Bentley,S.D., Edwards,G.F., Girvan,E.K., Kearns,A.M., Pichon,B., Hill,R.L., Larsen,A.R., Skov,R.L., Peacock,S.J., M, "Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study", Lancet Infect Dis 11 (8), 595-603 (2011) PUBMED 21641281.

    -Garcia-Alvarez,L., Holden,M.T., Lindsay,H., Webb,C.R., Brown,D.F., Curran,M.D., Walpole,E., Brooks,K., Pickard,D.J., Teale,C., Parkhill,J., Bentley,S.D., Edwards,G.F., Girvan,E.K., Kearns,A.M., Pichon,B., Hill,R.L., Larsen,A.R., Skov,R.L., Peacock,S.J., M, "Direct Submission", Submitted (05-APR-2012) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Holden,M., "Direct Submission", Submitted (02-FEB-2011) to the INSDC. Holden M., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UNITED KINGDOM.


DNA sequence :
TTGAAAAAATTAATAATTTTAGTCGTGTTAGCGTTGATATTAAGTGCTTGTAATAGTAAGAATTCAACTAATAACGACAT
TGAAAAGATCGAAAAAAAATATGGTGCTAACGTAGGTATGTATGCTCTTAATACTCAAAATGGTAAAGAATTATCATTTA
ATGAAAATAAGCGTTTTGCATATGCTTCCACATTAAAAACTATAAGTAGCGCAATGCTGCTTGAACAAACACCTTACAAC
AAATTAGATAAAAAAATTCACATTAATAAAGATGATATTGTTCCATATTCACCAGTGTTAGAAAAATATATTGGCAAAGA
GATAACTTTAAAAAAGCTTATAGAAGCTACCATGTTATTTAGCGATAACACGGCTAATAATAAAATTATCGATGAATTGG
GAGGATATGGGCAAGTAAAAACGAAACTGATAGATTTAGGCGATACAACGACACATCCATCTAGAAAAGAACCAGACTTA
AATTTTTATTCACCAAAGGATAAACGAGATACAAGTACTCCATTAGCCTATGGTAAAACTTTAAAGAAACTTATAGCTGA
TGGAGATCTTAGCAAAGCAAACAAAGATTTCTTACTTAATCTAATGTTCAAAAATAAAAGTGGCGATACATTAATTAAGG
ATGGTGCACCTTCAAACTTTAAAGTTATGGATAAGAGCGGTCAAGCACTAACATACGGTTCAAGAAACGATGTTGCGTTT
GTTTATCCAGATGGACAAGATAAACCTATAATTCTGGTGATATTTACAAATAAAGATAGAAAAGATGGTAAACCTAATGA
CAAAATAGTAAGTGAGGTTGCTGAAATTGTACTAAAAAATATTAATGAGTAA

Protein sequence :
MKKLIILVVLALILSACNSKNSTNNDIEKIEKKYGANVGMYALNTQNGKELSFNENKRFAYASTLKTISSAMLLEQTPYN
KLDKKIHINKDDIVPYSPVLEKYIGKEITLKKLIEATMLFSDNTANNKIIDELGGYGQVKTKLIDLGDTTTHPSRKEPDL
NFYSPKDKRDTSTPLAYGKTLKKLIADGDLSKANKDFLLNLMFKNKSGDTLIKDGAPSNFKVMDKSGQALTYGSRNDVAF
VYPDGQDKPIILVIFTNKDRKDGKPNDKIVSEVAEIVLKNINE