Name : cagA (HPB8_741)
Accession : YP_003728762.1
PAI name : cag PAI
PAI accession : NC_014256_P1
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : cytotoxin-associated protein A
Function : -
Note : Cytotoxicity-associated immunodominant antigen (120 kDa protein) (CAG pathogenicity island protein 26), CagA exotoxin
Homologs in the searched genomes : 49 hits ( 47 protein-level, 2 DNA-level )
Publication :
-Blom,J., "Direct Submission", Submitted (30-NOV-2009) Blom J., Cebitec, Bielefeld University, Universitaetsstr. 25, 33615, GERMANY.
-Farnbacher,M., Jahns,T., Willrodt,D., Daniel,R., Haas,R., Goesmann,A., Kurtz,S. and Rieder,G., "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8", BMC Genomics 11, 335 (2010) PUBMED 20507619 REMARK Publication Status: Online-Only.
-Farnbacher,M., Jahns,T., Willrodt,D., Daniel,R., Haas,R., Goesmann,A., Kurtz,S. and Rieder,G., "Direct Submission", Submitted (18-JUN-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
| DNA sequence : | |
ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATA
ACAGGCAAGCTTTTGAGAAAATCTCGCAGCTAAGGGAGAAATTCGCTAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAAACTTTATCAGTAAGAGCAGTGATTTAATCAACAAAGACGGTCTCATTGATACAGGTTCTTCCATAAA
AAGCTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCATCTCAAATCA
ACACCCAAAAAATCCGAGGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTG
AGGTCTGCCAAACAAGCTCTTGCAGGAATTATCATAAGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTGA
TGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGAGATCCTACTGGTGGGGATTGGTTTGATA
TTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAACCAGTTCCTCATGTC
CAACCAGATGTAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGAATCTAGAGATTTACTTGATGAAAGGGGTAA
TTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCCAATTACAAGTTCA
ACCAATTATTGGTTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCA
TTATTGTATGGAAACAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTCATAAAAACCAACAAGGCAA
CAATGTGGCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACA
ACCCTAGTTTTTATCTCTACAAAGAAGATCAGCTCACAGGCTTGAAACAAGCATTGAGTCAAAAAGAGATCCAAAACAAA
GTAGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAA
TGAGATTGAAGATTTTCAAAAAGACCATAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAA
AAGACAAAAAACATTTAGCTTTAGTTACTGAGTTTGGTAGTGGGGACTTGAGCTACACTCTCAAAGATTATGGGAAAAAA
GCAGATAAAGCTTTAGATAGGGAGATAAAAACCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTA
TTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTGGAAG
CAAATCTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATATAAGGCGAGACTTA
GAAGAGAAACTGGGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAGGA
ATTGGTTGGAAAAGTTTTAAACCTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAG
CTCAGAAAAATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGTGAAAAAATTGGAGAACAGAAAC
GACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCAATTATCAATGAAGAGGC
TAGTAAGGAAGCAAGAGTGGCCGCTTGCGTTCAGAAGTTTAAAGGCATCAAAATGGAATTGTCTGATAAGTTTGAAAACA
TCAACAAGAATTTGAAAGACTTTGATAAATCTTTTGATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAA
GAAACGCTAAAAGCCCTTAAAGGCTCGGTGAAGGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAA
TACAGCTTTGAATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATT
CCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAGTGGCTAAAGCA
ACAGGCGATTTCAGTGGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTTCTCAAAAGGACAATTGGCTCAACAAGCTCA
AAAAAATGAAGATTTCAATACTGGAAAAAATTCTGAACTATACCAATCCGTTAAGAATGGTGTAAATGGAACCCTAGTCG
GTAATGGGTTATCTGGAATAGAGGCCACAGCTCTCACCAAAAATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTT
AAAAATTTCAATAACAATAATAATGGTCTCAAAAACAGCGGAGAACCCATTTATGCTCAGGTTAATAAAAAGAAAACAGG
ACAAGTAGCTAGCCCTGAGGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAAAGCAAAAATTGACCAATTCAATCAAG
TAGCAAGTGGTTTGGGTGGTGTAGGGCAAGCGGGATTCTCTTTGAAAGGGCATACTAAAGTTGATGATCTCAGTAAGGTA
GGGCGATCAGTTAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAA
AGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTCAGAAAATTGACAATCTCAATCAGGCGGTAT
CAGAAGCTAAAGCATGTCATTTTGACAACCTAGATCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATG
AATCTATATGTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAATTGGACAATTATGCTATTAACAGCCACAC
ACGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGTGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGC
TCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAAC
CAGAAAAATATGAAAGATTATTCTGATTCATTCAAGTTTTCCACCAGGTTGAGCAATGCTGTAAAAGACATTAAGTCTGG
CTTTGTGCAATTTTTAACCAATACATTTTCTATGGGATCTTACAGCTTGATGAAAGCAAGTGTGGAACATGGAGTCAAAA
ATACTAATACAAAAGGTGGTTTCCAAAAATCTTAA
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| Protein sequence : | |
MTNETINQQPQTEAAFNPQQFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREKFANKAIKNPTKKN
QYFSNFISKSSDLINKDGLIDTGSSIKSFQKFGTQRYQIFMNWVSHQKDPSQINTQKIRGFMENIIQPPISDDKEKAEFL
RSAKQALAGIIIRNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWFDIFLSFVFNKKQSSDLKETLNQEPVPHV
QPDVATTTTDIQSLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLVHNNALSSVLMGSHDGIEPEKVS
LLYGNNGGPEARHDWNATVGHKNQQGNNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQKEIQNK
VDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDHKAYLDALGNDHIAFVSKKDKKHLALVTEFGSGDLSYTLKDYGKK
ADKALDREIKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEANLSKVAVFNLPNLNNLAITSYIRRDL
EEKLGAKGLSPQEANKLIKDFLNSNKELVGKVLNLNKAVAEAKNTGNYDEVKKAQKNLEKSLRKREHLEKEVVKKLENRN
DNKNRMEAKAQANSQKDKIFAIINEEASKEARVAACVQKFKGIKMELSDKFENINKNLKDFDKSFDDFKNGKNKDFSKAE
ETLKALKGSVKDLGINPEWISKVENLNTALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKA
TGDFSGVEQALADLKNFSKGQLAQQAQKNEDFNTGKNSELYQSVKNGVNGTLVGNGLSGIEATALTKNFSDIKKELNEKF
KNFNNNNNGLKNSGEPIYAQVNKKKTGQVASPEEPIYTQVAKKVKAKIDQFNQVASGLGGVGQAGFSLKGHTKVDDLSKV
GRSVSPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKACHFDNLDQMIDKLKDSTKKNVM
NLYVESAKKVPTSLSAKLDNYAINSHTRINSNVKNGTINEKVTGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFN
QKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNTFSMGSYSLMKASVEHGVKNTNTKGGFQKS
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