PAI Gene Information


Name : iagA (t2778)
Accession : NP_806479.1
PAI name : SPI-1
PAI accession : NC_004631_P2
Strain : Salmonella enterica RSK2980
Virulence or Resistance: Virulence
Product : invasion protein regulator
Function : -
Note : Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system
Homologs in the searched genomes :   42 hits    ( 42 protein-level )  
Publication :
    -Deng,W., Liou,S.-R., Plunkett,G. III, Mayhew,G.F., Rose,D.J., Burland,V., Kodoyianni,V., Schwartz,D.C. and Blattner,F.R., "Direct Submission", Submitted (25-SEP-2002) Laboratory of Genetics, University of Wisconsin - Madison, 445 Henry Mall, Madison, WI 53706, USA.

    -Deng,W., Liou,S.R., Plunkett,G. III, Mayhew,G.F., Rose,D.J., Burland,V., Kodoyianni,V., Schwartz,D.C. and Blattner,F.R., "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18", J. Bacteriol. 185 (7), 2330-2337 (2003) PUBMED 12644504.

    -Deng,W., Liou,S.R., Plunkett,G. III, Mayhew,G.F., Rose,D.J., Burland,V., Kodoyianni,V., Schwartz,D.C. and Blattner,F.R., "Direct Submission", Submitted (10-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.


DNA sequence :
ATGCCACATTTTAATCCTGTTCCTGTATCGAATAAAAAATTCGTCTTTGATGATTTCATACTCAACATGGACGGCTCCCT
GCTACGCTCAGAAAAGAAAGTCAATATTCCGCCAAAAGAATATGCCGTTCTGGTCATCCTGCTCGAAGCCGCCGGCAAGA
TTGTGAGTAAAAACACCTTATTGGACCAAGTATGGGGCGACGCGGAAGTTAACGAAGAATCTCTTACCCGCTGTATCTAT
GCCTTACGACGTATTCTGTCGGAAGATAAAGAGCATCGTTACATTGAAACACTGTACGGACAGGGTTATCGGTTTAATCG
TCCGGTCGTAGTGGTGTCTCCGCCAGCGCCGCAACCTACGACTCATACATTGGCGATACTTCCTTTTCAGATGCAGGATC
AGGTTCAATCCGAGAGTCTGCATTACTCTATCGTGAAGGGATTATCGCAGTATGCGCCCTTTGGCCTGAGCGTGCTGCCG
GTGACCATTACGAAGAACTGCCGCAGTGTTAAGGATATTCTTGAGCTCATGGATCAATTACGCCCCGATTATTATATCTC
CGGGCAGATGATACCCGATGGTAATGATAATATTGTACAGATCGAGATAGTTCGGGTTAAAGGTTATCACCTGCTGCACC
AGGAAAGCATTAAGTTGATAGAACACCAACCCGCTTCTCTCTTGCAAAACAAAATTGCGAATCTTTTGCTCAGATGTATT
CCCGGACTTCGCTGGGACACAAAGCAAATTAGCGAGCTAAATTCGATTGACAGTACCATGGTCTACTTACGCGGTAAGCA
TGAGTTAAATCAATACACCCCCTATAGCTTACAGCAAGCGCTTAAATTGCTGACTCAATGCGTTAATATGTCGCCAAACA
GCATTGCGCCTTACTGTGCGCTGGCAGAATGCTACCTCAGCATGGCGCAAATGGGGATTTTTGATAAACAAAACGCAATG
ATCAAAGCTAAAGAACATGCGATTAAGGCGACAGAGCTGGACCACAATAATCCACAAGCTTTAGGATTACTGGGGCTAAT
TAATACGATTCACTCAGAATACATCGTCGGGAGTTTGCTATTCAAACAAGCTAACTTACTTTCGCCCATTTCTGCAGATA
TTAAATATTATTATGGCTGGAATCTTTTCATGGCTGGTCAGTTGGAGGAGGCCTTACAAACGATTAACGAGTGTTTAAAA
TTGGACCCAACGCGCGCAGCCGCAGGGATCACTAAGCTGTGGATTACCTATTATCATACCGGTATTGATGATGCTATACG
TTTAGGCGATGAATTACGCTCACAACACCTGCAGGATAATCCAATATTATTAAGTATGCAGGTTATGTTTCTTTCGCTTA
AAGGTAAACATGAACTGGCACGAAAATTAACTAAAGAAATATCCACGCAGGAAATAACAGGACTTATTGCTGTTAATCTT
CTTTACGCTGAATATTGTCAGAATAGTGAGCGTGCCTTACCGACGATAAGAGAATTTCTGGAAAGTGAACAGCGTATAGA
TAATAATCCGGGATTATTACCGTTAGTGCTGGTTGCCCACGGCGAAGCTATTGCCGAGAAAATGTGGAATAAATTTAAAA
ACGAAGACAATATTTGGTTCAAAAGATGGAAACAGGATCCCCGCTTGATTAAATTACGGTAA

Protein sequence :
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGKIVSKNTLLDQVWGDAEVNEESLTRCIY
ALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLP
VTITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAM
IKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLK
LDPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR