PAI Gene Information


Name : prgK
Accession : NP_457265.1
PAI name : SPI-1
PAI accession : NC_003198_P5
Strain : Salmonella enterica RSK2980
Virulence or Resistance: Virulence
Product : pathogenicity 1 island effector protein
Function : -
Note : Similar to several proteins essential for protein secretion by a type III system: Salmonella typhimurium protein precursor PrgK required for invasion of epithelial cells SW:PRGK_SALTY (P41786) (252 aa) fasta scores: E(): 0, 99.6% id in 252 aa and Shigella
Homologs in the searched genomes :   79 hits    ( 79 protein-level )  
Publication :
    -Parkhill,J., "Direct Submission", Submitted (25-OCT-2001) Submitted on behalf of the Salmonalla sequencing team, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

    -Parkhill,J., Dougan,G., James,K.D., Thomson,N.R., Pickard,D., Wain,J., Churcher,C., Mungall,K.L., Bentley,S.D., Holden,M.T., Sebaihia,M., Baker,S., Basham,D., Brooks,K., Chillingworth,T., Connerton,P., Cronin,A., Davis,P., Davies,R.M., Dowd,L., White,N., , "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18", Nature 413 (6858), 848-852 (2001) PUBMED 11677608.

    -Parkhill,J., Dougan,G., James,K.D., Thomson,N.R., Pickard,D., Wain,J., Churcher,C., Mungall,K.L., Bentley,S.D., Holden,M.T., Sebaihia,M., Baker,S., Basham,D., Brooks,K., Chillingworth,T., Connerton,P., Cronin,A., Davis,P., Davies,R.M., Dowd,L., White,N., , "Direct Submission", Submitted (10-SEP-2013) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.


DNA sequence : 
ATGATTCGTCGATATCTATATACCTTTCTGCTGGTAATGACCCTTGCCGGCTGTAAGGATAAGGATCTTTTAAAAGGACT
GGACCAGGAACAGGCTAATGAGGTCATTGCCGTTCTGCAAATGCACAATATAGAGGCGAATAAAATTGATAGCGGAAAAT
TGGGCTATAGCATTACCGTTGCTGAGCCTGATTTTACCGCTGCGGTGTACTGGATTAAAACTTATCAGCTTCCTCCCCGG
CCACGGGTGGAAATAGCGCAGATGTTCCCGGCGGATTCGCTGGTATCGTCTCCGCGAGCTGAAAAGGCCAGGTTATATTC
GGCTATTGAACAGCGACTGGAACAGTCATTACAGACGATGGAGGGCGTGCTCTCCGCCAGGGTCCATATTAGTTATGATA
TTGATGCTGGTGAAAATGGCCGTCCGCCAAAACCTGTTCATCTGTCGGCATTAGCCGTATATGAACGAGGTTCGCCGCTT
GCGCATCAGATCAGCGATATCAAGCGTTTCTTAAAGAATAGTTTTGCCGATGTGGATTATGACAACATTTCTGTTGTGTT
GTCAGAACGTTCTGATGCCCAATTACAGGCTCCCGGCACACCAGTAAAACGTAATTCTTTTGCAACCAGTTGGATTGTGT
TGATTATTTTGTTATCCGTGATGTCAGCAGGCTCTGGCGTCTGGTATTACAAAAACCATTATGCCCGCAATAAGAAAGGC
ATAACGGCTGATGATAAGGCGAAATCGTCAAATGAATAG

Protein sequence : 
MIRRYLYTFLLVMTLAGCKDKDLLKGLDQEQANEVIAVLQMHNIEANKIDSGKLGYSITVAEPDFTAAVYWIKTYQLPPR
PRVEIAQMFPADSLVSSPRAEKARLYSAIEQRLEQSLQTMEGVLSARVHISYDIDAGENGRPPKPVHLSALAVYERGSPL
AHQISDIKRFLKNSFADVDYDNISVVLSERSDAQLQAPGTPVKRNSFATSWIVLIILLSVMSAGSGVWYYKNHYARNKKG
ITADDKAKSSNE