PAI Gene Information


Name : HP0522 (HP0522)
Accession : NP_207318.1
PAI name : cag PAI
PAI accession : NC_000915_P1
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : cag pathogenicity island protein (cag3)
Function : -
Note : similar to GP:1800159 percent identity: 98.13; identified by sequence similarity
Homologs in the searched genomes :   46 hits    ( 46 protein-level )  
Publication :
    -Marais,A., Mendz,G.L., Hazell,S.L. and Megraud,F., "Metabolism and genetics of Helicobacter pylori: the genome era", Microbiol. Mol. Biol. Rev. 63 (3), 642-674 (1999) PUBMED 10477311.

    -Raymond,J., Thiberge,J.M., Kalach,N., Bergeret,M., Dupont,C., Labigne,A. and Dauga,C., "Using macro-arrays to study routes of infection of Helicobacter pylori in three families", PLoS ONE 3 (5), E2259 (2008) PUBMED 18493595 REMARK Publication Status: Online-Only.

    -Tomb,J.-F., White,O., Kerlavage,A.R., Clayton,R.A., Sutton,G.G., Fleischmann,R.D., Ketchum,K.A., Klenk,H.P., Gill,S., Dougherty,B.A., Nelson,K., Quackenbush,J., Zhou,L., Kirkness,E.F., Peterson,S., Loftus,B., Richardson,D., Dodson,R., Khalak,H.G., Glodek,, "The complete genome sequence of the gastric pathogen Helicobacter pylori", Nature 388 (6642), 539-547 (1997) PUBMED 9252185.

    -Tomb,J.-F., White,O., Kerlavage,A.R., Clayton,R.A., Sutton,G.G., Fleischmann,R.D., Ketchum,K.A., Klenk,H.P., Gill,S., Dougherty,B.A., Nelson,K., Quackenbush,J., Zhou,L., Kirkness,E.F., Peterson,S., Loftus,B., Richardson,D., Dodson,R., Khalak,H.G., Glodek,, "Direct Submission", Submitted (18-SEP-2001) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.

    -Tomb,J.-F., White,O., Kerlavage,A.R., Clayton,R.A., Sutton,G.G., Fleischmann,R.D., Ketchum,K.A., Klenk,H.P., Gill,S., Dougherty,B.A., Nelson,K., Quackenbush,J., Zhou,L., Kirkness,E.F., Peterson,S., Loftus,B., Richardson,D., Dodson,R., Khalak,H.G., Glodek,, "Direct Submission", Submitted (06-AUG-1997) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA.

    -Wen,Y., Marcus,E.A., Matrubutham,U., Gleeson,M.A., Scott,D.R. and Sachs,G., "Acid-adaptive genes of Helicobacter pylori", Infect. Immun. 71 (10), 5921-5939 (2003) PUBMED 14500513.


DNA sequence : 
ATGTTTAGAAAACTAGCAACCGCTGTATCGCTCATAGGCTTACTAACCTCTAACACTCTTTATGCTAAAGAAATAAGTGA
AGCCGATAAGGTCATTAAGGCCACTAAAGAAACTAAAGAGACCAAGAAAGAAGCTAAACGACTCAAAAAAGAAGCTAAAC
AGCGCCAACAGATCCCTGATCATAAGAAACCTCAATATGTCTCTGTTGATGACACAAAAACTCAAGCGCTGTTTGATATA
TACGACACCTTGAATGTGAATGACAAAAGCTTTGGGGATTGGTTTGGTAATAGCGCTTTGAAAGACAAAACCTATCTCTA
CGCTATGGATCTATTGGATTACAACAACTATTTATCCATAGAAAACCCCATTATCAAAACAAGAGCAATGGGAACTTATG
CGGATTTGATTATCATCACAGGCTCATTAGAGCAAGTCAATGGGTATTACAACATTCTAAAAGCGCTCAACAAACGCAAC
GCTAAGTTTGTGTTAAAAATCAATGAGAACATGCCTTATGCCCAAGCGACTTTTTTAAGAGTGCCAAAAAGAAGCGATCC
TAATGCCCACACGCTTGATAAGGGAGCGTCAATTGATGAGAATAAGCTTTTTGAACAACAAAAGAAAATGTATTTCAATT
ACGCTAACGATGTGATCTGCAGACCCGATGATGAAGTGTGTTCGCCCCTAAGAGATGAGATGGTAGCTATGCCCACTAGC
GATAGCGTTACTCAAAAACCCAATATCATTGCTCCTTATAGCTTGTATAGACTAAAAGAGACAAATAACGCCAATGAGGC
CCAACCATCACCTTATGCCACTCAAACCGCTCCCGAAAACAGCAAAGAGAAGCTCATAGAAGAGCTAATCGCTAACTCCC
AACTCGTAGCCAATGAAGAAGAGAGGGAAAAGAAACTCTTAGCAGAAAAAGAAAAACAAGAGGCTGAATTGGCTAAATAT
AAGCTCAAAGACTTAGAAAATCAAAAGAAACTAAAAGCTTTAGAAGCAGAGTTGAAAAAGAAAAACGCTAAGAAACCTAG
AGTAGTGGAAGTGCCTGTTTCTCCTCAAACAAGTAATTCTGATGAAACAATGAGAGTTGTCAAAGAAAAAGAGAACTATA
ATGGGTTATTAGTGGATAAGGAGACCACGATCAAAAGAAGCTATGAGGGGACTTTGATCAGTGAAAATTCTTACAGCAAA
AAAACACCTCTCAACCCTAATGACTTGAGGAGCTTAGAAGAAGAAATTAAGAGCTACTATATCAAGTCTAATGGCTTGTG
TTATACTAATGGCATTAACCTCTATGTAAAAATCAAAAACGACCCCTATAAAGAGGGAATGCTGTGTGGTTATGAGAGCG
TTCAAAATCTGCTCTCACCTCTAAAGGACAAGCTCAAATACGACAAACAAAAGTTACAAAAAGCGTTACTGAAAGATTCA
AAGTAA

Protein sequence : 
MFRKLATAVSLIGLLTSNTLYAKEISEADKVIKATKETKETKKEAKRLKKEAKQRQQIPDHKKPQYVSVDDTKTQALFDI
YDTLNVNDKSFGDWFGNSALKDKTYLYAMDLLDYNNYLSIENPIIKTRAMGTYADLIIITGSLEQVNGYYNILKALNKRN
AKFVLKINENMPYAQATFLRVPKRSDPNAHTLDKGASIDENKLFEQQKKMYFNYANDVICRPDDEVCSPLRDEMVAMPTS
DSVTQKPNIIAPYSLYRLKETNNANEAQPSPYATQTAPENSKEKLIEELIANSQLVANEEEREKKLLAEKEKQEAELAKY
KLKDLENQKKLKALEAELKKKNAKKPRVVEVPVSPQTSNSDETMRVVKEKENYNGLLVDKETTIKRSYEGTLISENSYSK
KTPLNPNDLRSLEEEIKSYYIKSNGLCYTNGINLYVKIKNDPYKEGMLCGYESVQNLLSPLKDKLKYDKQKLQKALLKDS
K