PAI Gene Information


Name : escU
Accession : CAI43886.1
PAI name : LEE
PAI accession : AJ303141
Strain : Escherichia coli 042
Virulence or Resistance: Virulence
Product : EscU protein
Function : -
Note : -
Homologs in the searched genomes :   75 hits    ( 75 protein-level )  
Publication :
    -Jores,J., "Direct Submission", Submitted (02-JAN-2001) Jores J., Institut fuer Mikrobiologie und Tierseuchen, Freie Universitaet Berlin, Philippstrasse 13, 10115 Berlin, Berlin, 10115, GERMANY REMARK revised by [3].

    -Jores,J., "Direct Submission", Submitted (09-SEP-2004) Jores J., Institut fuer Mikrobiologie und Tierseuchen, Freie Universitaet Berlin, Philippstrasse 13, 10115 Berlin, Berlin, 10115, GERMANY.

    -Jores,J., Rumer,L., Kiessling,S., Kaper,J.B. and Wieler,L.H., "A novel locus of enterocyte effacement (LEE) pathogenicity island inserted at pheV in bovine Shiga toxin-producing Escherichia coli strain O103:H2", FEMS Microbiol. Lett. 204 (1), 75-79 (2001) PUBMED 11682182.

    -Jores,J., Wagner,S., Rumer,L., Eichberg,J., Laturnus,C., Kirsch,P., Schierack,P., Tschape,H. and Wieler,L.H., "Description of a 111-kb pathogenicity island (PAI) encoding various virulence features in the enterohemorrhagic E. coli (EHEC) strain RW1374 (O103:H2) and detection of a similar PAI in other EHEC strains of serotype 0103:H2", Int. J. Med. Microbiol. 294 (7), 417-425 (2005) PUBMED 15715170.

    -Rumer,L., Jores,J., Kirsch,P., Cavignac,Y., Zehmke,K. and Wieler,L.H., "Dissemination of pheU- and pheV-located genomic islands among enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli and their possible role in the horizontal transfer of the locus of enterocyte effacement (LEE)", Int. J. Med. Microbiol. 292 (7-8), 463-475 (2003) PUBMED 12635929.


DNA sequence : 
ATGAGTGAAAAAACAGAAAAGCCCACACCCAAAAAACTAAGGGATCTAAAAAAGAAGGGCGATGTAACAAAAAGTGAAGA
GGTAATGGCTGCAGTGCAGTCATTAATCTTATTTTCATTTTTTTCTTTATATGGTGCGAGTTTTTTCGTTGAGGTTGTTG
AGTTAGTTAATACGACTATAGACTCGCTAAATAGACCGTTTTTGTATGCCATTCGTGAAATATTAGGTGCGGTATTAAAC
ATATTTTTATTGTATATTTTGCCAATTTCTTTGATTGTCTTTGTTGGAACTGTTACAACTGGTGTATCACAAACAGGATT
CATCTTTGCGGTTGAAAAAATAAAACCATCGGCTCAGAAGATTAGTGTAAAAAATAACCTGAAAAATATTTTTTCTGTAA
AGAGTATTTTTGAGCTGCTTAAGTCAGTATTTAAGTTAGTGATAATTACTCTCATTTTTTACTTTATGGGGCATTCATAT
GCAAATGAGTTTGCAAATTTCACAAGACTGAACGCATATCAAACTCTTGTCGTTGTTGCCTTTTTTGTTTTTCTTTTATG
GAAAGGCGTGTTATTCGGATATCTACTCTTTTCAGTATTTGATTTCTGGTTCCAGAAGCATGAGGGACTGAAGAAAATGA
AAATGAGTAAAGATGAGGTGAAACGAGAAGCCAAGGATACTGATGGTAACCCTGAAATTAAAGGGGAGCGCCGTCGCCTT
CATTCTGAGATACAAAGTGGAAGTCTGGCTAATAACATCAAAAAATCAACCGTGATCGTCAAAAACCCGACTCACATTGC
GATTTGCCTATACTATAAACTCGGGGAGACTCCATTGCCTTTAGTTATTGAAACAGGAAAAGATGCCAAAGCTCTACAGA
TCATTAAACTGGCTGAACTCTATGATATTCCAGTGATTGAAGATATTCCTTTGGCAAGAAGTCTTTATAAGAACATACAT
AAAGGACAATACATAACAGAAGACTTTTTTGAACCTGTAGCACAATTGATTCGTATAGCAATAGATCTTGATTATTAA

Protein sequence : 
MSEKTEKPTPKKLRDLKKKGDVTKSEEVMAAVQSLILFSFFSLYGASFFVEVVELVNTTIDSLNRPFLYAIREILGAVLN
IFLLYILPISLIVFVGTVTTGVSQTGFIFAVEKIKPSAQKISVKNNLKNIFSVKSIFELLKSVFKLVIITLIFYFMGHSY
ANEFANFTRLNAYQTLVVVAFFVFLLWKGVLFGYLLFSVFDFWFQKHEGLKKMKMSKDEVKREAKDTDGNPEIKGERRRL
HSEIQSGSLANNIKKSTVIVKNPTHIAICLYYKLGETPLPLVIETGKDAKALQIIKLAELYDIPVIEDIPLARSLYKNIH
KGQYITEDFFEPVAQLIRIAIDLDY