PAI Gene Information


Name : efa1/lifA
Accession : CAI43818.1
PAI name : LEE
PAI accession : AJ303141
Strain : Escherichia coli 042
Virulence or Resistance: Not determined
Product : Efa1/LifA protein
Function : -
Note : -
Homologs in the searched genomes :   7 hits    ( 7 protein-level )  
Publication :
    -Jores,J., "Direct Submission", Submitted (02-JAN-2001) Jores J., Institut fuer Mikrobiologie und Tierseuchen, Freie Universitaet Berlin, Philippstrasse 13, 10115 Berlin, Berlin, 10115, GERMANY REMARK revised by [3].

    -Jores,J., "Direct Submission", Submitted (09-SEP-2004) Jores J., Institut fuer Mikrobiologie und Tierseuchen, Freie Universitaet Berlin, Philippstrasse 13, 10115 Berlin, Berlin, 10115, GERMANY.

    -Jores,J., Rumer,L., Kiessling,S., Kaper,J.B. and Wieler,L.H., "A novel locus of enterocyte effacement (LEE) pathogenicity island inserted at pheV in bovine Shiga toxin-producing Escherichia coli strain O103:H2", FEMS Microbiol. Lett. 204 (1), 75-79 (2001) PUBMED 11682182.

    -Jores,J., Wagner,S., Rumer,L., Eichberg,J., Laturnus,C., Kirsch,P., Schierack,P., Tschape,H. and Wieler,L.H., "Description of a 111-kb pathogenicity island (PAI) encoding various virulence features in the enterohemorrhagic E. coli (EHEC) strain RW1374 (O103:H2) and detection of a similar PAI in other EHEC strains of serotype 0103:H2", Int. J. Med. Microbiol. 294 (7), 417-425 (2005) PUBMED 15715170.

    -Rumer,L., Jores,J., Kirsch,P., Cavignac,Y., Zehmke,K. and Wieler,L.H., "Dissemination of pheU- and pheV-located genomic islands among enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli and their possible role in the horizontal transfer of the locus of enterocyte effacement (LEE)", Int. J. Med. Microbiol. 292 (7-8), 463-475 (2003) PUBMED 12635929.


DNA sequence :
ATGAGACTGCCAGAGAAAGTTCTTTTTCCTCCTGTCACTAGTGGCCTGTCAGGGCAGGAAAAACAAAAAAAACCGAAGAG
CATTACCGGATTTCAGGAAAATTATCAACGCAATATCAGGCCAATCAAAACAGCATCAGAAGCCCGACTACGCTTCTTTG
ATAAAATGGTTTCGAAAGAAAACTCTCTGGAAGATGTTGTTTCTTTAGGTGAAATGATTCAGAAGGAAATTTATGGGCAT
GAACAAAGAACATTTTCACCAGTTCATCATACAGGTAACTGGAAATCATCATTGTTACACAACGCGCTCCTTGGTCTGGC
AAATGTTTATAATGGCTTACGGGAAACAGAATACCCTAACACTTTCAACAGAGATGGTATAAAAAGTACTAACTCTTTTA
GAGATAACTTATTGACAAAAACAAGAACTCCCAGAGATAATTTTGAGGAAGGAATAAAACATCCTGAACATGCAACAATA
CCATATGACAACGACAATGAAAGTAATAAATTGCTAAAAGCAGGAAAGATAGCTGGTAACAATAACGAGCTGTTGATGGA
AATAAAAAAGGAATCCAAAAGCGACCATCAAATCCCCCTGTCAGATAAGTTCCTGAAAAGGAAAAAACGGTCTCCTGTAG
CTGAAGATAAAGTTCAAAACTCGTTAACACCAGAAAATTTTGTTCAGAAAATTTCACTTAGTGATGAGCTTAAAACAAAA
TATGCAAATGAAATTATAGAGATAAAAAGAATAATGGGAGAATACAATCTTTTACCGGATAAAAACAGTCGTAATGGTCT
AAAACTTCTACAGAAGCAAGCTGATTTACTAAAAATAATCATGGAGGATACCTCTGTTACAGAAAATATCTTTAAAAACA
TAGAGATGGCTATAGCAGATATAAAAAAGGAGTACTATTCGCATACAGTTGATATTGAGAAAAATATTCATGCCATATGG
GTTGCGGGTTCCCCACCTGAAAGCATCTCGGACTATATTAAGACTTTTCTCAAAACCTACAAAGAGTTTACTTACTATCT
TTGGGTTGATGAAAAAGCATTTGGAGCCGCGAAATTTACCAGTGTCTTAAAACAAATTGCATTTGATTTAGCATGCAGAA
CTATACAGCAGAATACTCCACAAAAAAATATTGATTTTATTAATCTATATAATGAAATAAGGAAGAAATACAACAACAAC
CCATCGGGACAACAAGAGTACTTAAACAAACTCAGAGAGCTTTATGCTACTTATCAAAAAATATCTACCCCTCTGAAACA
CATGTTTAATTCATTTTTTCTAGAAAACATGATTAAACTTCAGGATAATTTCTTCAACTATTGCATTGTCAAAGGTGTTA
CAGAGATTAATGATGAGTTACGAATAAACTACCTTAAAAATGTAATAAAACTGTCAGACGATGACATTGGTAATTATCAG
AAAACAATTAACGACAATAAAGATAGAGTAAAAAAACTAATTCTTGATTTACAGAAACAATTTGGTGAAAACCGTATTTC
AATTAAAGATGTTAACTCTTTAACCTCTCTTTCAAAATCAGAAAATAATCACAATTATCAAACTGAAATGTTGCTTCGAT
GGAACTATCCTGCCGCCTCAGACCTGCTCAGGATGTATATCCTTAAAGAGCATGGTGGTATTTATACAGACACAGACATG
ATGCCTGCATACTCTAAACAAGTAATTTTTAAAATTATGATGCAGACAAACGGAGATAATCGTTTCTTGGAAGATTTGAA
ACTACGTCGTGCAATATCTGATGGTGTATTAAGATATGTTAATAACCAAAATATTGATGAAGTTAACTATAATGAAATCA
GTGATGCAGATAAAAACATTATCAAGAAGATATTAACAGAAATATCTAAAATGCCAGAAGATAGCATTTTTACTAAGATC
AATACAAGGATTCCTCGAGACACAATGCCCATCCTTCGTCGTTATCACCTATGGCCTGATGGATGGAATATTCGTGGGCT
CAATGGATTCATGCTATCACATAAAGGTAGTGAAGTGATTGATGCTGTTATCGCAGGCCAGAATCAGGCTTACAGGGAAC
TAAGAAGAATAAGAGATAATATTCATAGTGAAATATACTTCAAACAAACTGATGAATTGTCCTCACTTCCAGATACAGAC
AAAATTGGAGGGATTCTGGTAAAAAAATACCTTTCAGGAAGTCTTTTTTCAAAATTCAGACAAGATACTATTATCCCGGA
GGCATTGAGCACCCTCCAGATATCAGGTCCTGACTTGATTCAAAGAAAGATGTTGCAATTTTTCAGGAGTAGAGGGGTGT
TAGGTGAAGAGTTCATTAATGAAAGAAAACTGAGTGATAAAGCTTATATTGGTGTCTACAAAACAACTGGCACAGGGAAA
TATGACTGGTTAAACCCTGAATCGATCGGCGTTAATGATGTCACGCCCGCAGATGAAAGTACCTGGTGTATAGGAAAAGG
CCGGTGTGTTGATGACTTCCTGTTCAAAGATGTTTCAAAACTAAAAACAGAAAATCTTCCAGAATTATTCTTAACAAAAA
TAGATACTGATACGTTTTTCTCTCAGTGGTCAACCAAAACCAAGAAAGATCTGCAAAAAAAAATACAAGACCTTACTGTA
CGTTATAATGAGCTAATTGACTCGTCGACTATCGACTTTAAAAATCTATATGAAATAGATCAAATGCTCCATATGATTAT
GCTAGAGATGAATGATGATATAGCCAAAAGGTCATTGTTTTCATTGCAAGTTCAAATAGCCGAAAAAATTCGGAGGATGA
CCATTCCTGTAGACAATATAATTAACATCTATCCTGATCTACATAAAAAAAATGACAATGATCTGAGTATGTCCATAAAA
GGCTTTCTTGCGAGTAATCCACATACAAAAATAAATATTCTTTATAGCAATAAGACTGAGCATAATATTTTTATAAAGGA
TTTATTCTCCTTCGCAGTTATGGAAAATGAGTTAAGAGACATTATCAATAACATGAGCAAGGATAAGACTCCTGAAAACT
GGGAAGGGAGGGTAATGTTACAAAGATATCTCGAATTAAAAATGAAAGATCATCTTAGTTTGCAATCTTCTCAGGAAGCA
AATGAGTTTCTTGAAATATCTACTTTTATTTATGAGAATGATTTCTTGAGAGAAAAGATTGAAGCAGTAAAAAACAAAAT
GAATTCTCACGAACTTTATTTTGAAAAAATAAAAAAAGAACAAAACACATGGCAGGATCTGTCCACAAAAGAACAAAAAT
TACAGCTTATTAAAGCATTGAAAGAAATTTCAGGAAATACAGAGAAGGACTCTCATTACGATAGACTTCTTGATGCTTTT
TTTAAAAAACATAATGAAAATATTCATAATAAAATACAAAGAATAAAAGACGAGTTCAAGGAATACTCCCGTGTAACCAT
TCATAATATAGATAAAGTTATATTTAAAGGGCAAACACTGGATCGTCTTTATCATGAAGGATATGTATTTTCTGATATCA
ATACCTTGTCTCGTTATACACTACACGGACTAGGAATAACTGGTGTACATACTGAAGAAAACCTGCTACCAGCTCCTTCA
TCGTCCTTAATTAATATATTGAAAGAACATTATAATGAAGATGAAATTAGTGCGAAATTACCACTAGCATATGATTACAT
TTTAAATAAAAAAGAATCAAGCTCTATTCCTGTTGAAATTTTGAACAAACTTTCAGAGTTACCACCACATGAACTACTCA
CACCTGTTCTTGGCCAGAGTGTTAATCCTCTGGGCATGGGCTACTCATCCGATAATGGAAAAATCACAGAGCAAGTAATA
GTCAGTGGAGCTGATGGATTTGATAATCCCATATCTGGACTTATATATACCTATCTTGAAGATCTATATAACATCCATGT
AAGGATGCGAGAAGGTACACTAAATTCACAGAATCTTCGTCAGCTTCTGGAAAACTCTGTTTCTTCATGCTTTTTGACTG
AGCAAAGTATTAATAAATTACTTAGTGAGGCAGAAAAAAGGCCTTATCAGTCTTTAACAGAAATACATCAGCATCTCACA
GGATTACCAACTATTGCCGATGCAACCCTTTCATTACTTTCTGTTGGATTACCTGGTACGGGAAAACTATTGCGCAGGGA
GCAGGACTATGGGCGTCCACCAGTTACAGCAATTCAGGATTCCACATTTGTACTCCCTTATAATTTCAAAGGTATTGGTT
TTAACGATAACATTATATCCTCTGCACCTGTAGTCTCCTCATTACATTTTATCGCTGAACATGCGAAATATACTTTGTTG
TCATGGCCTGAGTTTTATCGTCATCATGCACAGCGATGGTTCGAAATGGCTAAAGGATATGGAAGCCAGAATATTGATTT
TCACCCTCAGTCTCTATTGGTAACCCAAGAAGGACGCTGTATGGGATTAGCCTTACTTTATTTACAGACTGAAGATACTG
CTCATTATAGCATTCTCCAGGAAAACCTAATGACTGTGAGTGCACTTCATCAGACCAGTAATCGCGATAAGTTGCCACTG
TCCAAAGATGATAATTCCTTAATGACAAGAACTTATAGTCTGATTGAAATGCTACAGTATCAGGGAAACAAATATATTAC
CAACGAATCGCTACTACATAAGACCGCATGGAACCAAGAAAGAATAACTTTATTATTCAATGAAAAAGGAGTTAAGCGAG
CCCTGATAAGCACGCCTAATCATACTCTGGTTCTGCAACAACTGGAGGATATTTACCGGCTCACTGATCCAAATTTTGGG
CATGCAGATTTCCTTTCACCTATAGATGCTCTGAAGTTTATTGAGGCTATGATACAATTAACTCCAACACTTCAGGAATA
TTATGGCCTATTAAACAAAGACATTAATAAACATATACAAGTACATTATGCCGAATCAGATATGGTCTGGAATAAGCTTC
TGCCAGAAAATGATGCTGGACTGAGCACCAGAATTCAGCACACCACCACCGACCGTCTGGCGAATCTGGCTGAACCAGTC
GCTGTTGCAGGTATCTCCCTGCCAGTAAAAACACTTTATGATATCGGAGCCACCCTTGACGGTCGGCGCATCACCTCTCC
TCCAACATCGGAGCAAATCCCTTCTCTGCGTCTCAACGGTGATGTTCTGAATGATTATCTGTCCCGCACAGTTCTGACTC
CAGAACAGGCTGATAACATAAGAAAAATACTGCACACTCAGGGAATACGCAGCGGTACCCGTCCCATAGATCCGGAGATG
ATTCGTGGGACGCAGGATGACCTAGTTTCGTCACAGACTCGTCTGCAAAGGCAAGCAACACGGGTTAAACAGCAACTCGC
CGGTGTACTTGATACTCTGCAACAGCACTTCCAGAACATTCCACGTTCATCCGGTCGTCATCTTTCTGTAGAGAATATTG
AGCTGGCTGATATCGGAAGTGGGCGTTTCAACCTTCAAATTCGAGATGGAGAAACATTGCATACCACTTCTGTGGAAGTA
CCGGAAGTTGTGTCCCGTTTTCAGAAACTTTCTACCATGCTTTCAGCCCTGCCTGCCAGTGGAATCATGGATTTCGACCT
CGGCATGAGTGTGGTCGGAGTCGTCCAGTATGCCCGCCTGCTACAGCAGGGGCACGAAGACAGTACCCTAGCCAAGATAA
ATCTAGCTATGGATATCAAGCAACTTTCCGAAGCAACTCTCGGCAGCATGATTCAGATTGCCGGGAATAAGTTTCTCAAT
ACAGAAGGAATCCAGGGGTTCAGACTGGAAAGCGCCGTCGCTGAAGGTATGCGCTCAGTAGCAACCCGTACCGGAGGCAC
AATGGGGAAAGCCCTTTCTGCCAGTGCCCGTGTTCTTGAACTGCCTGTACTGGAAACAGTTCTGGGGACATGGAACCTGT
ACAACAGCGTCATTCAGCTCCAGCAAGCTACATCTTATTCTGAGACAATGGCTGCCCGGGTACAGATTGCGTTTGATTCC
ATTTCTCTGGGATTAACTGCCGCTTCGGTAGCTTTCCCGCCACTAATTATTGCCACTGGCCCCATTGCGGCTATTGGTAT
GGGAGCTTCCAGTATTGCACGTAATGTGGCACGGAAAGAAGAACGGCATACACAATGGCTGGAATATAAAAAATTCCTGA
CTGATGGCAGTAAACACATTGTTGTGGCCTCTCCGGAAAGAGGTCTGCTGGATTTCTCCGGAAACAAAGTTTTTGGAAAA
ATGGTGCTGGATCTGCGTCAGTCTCCTCCTCTCTTGCATGGAGAAAGCTCTTTTAACGCTGACCGCAAAATCGGTCATCG
TCCGGATCTGGGGGACTGGCAAATTCGTGAGAAGGTGGGGTATGCCAACAGTATCAGTCCCTACTCTTCCCTGGCGCACG
GTTACGCCAACAGTAAATGGCCACAAACAATACCGAAAATTCCCTCGGGAGAATATGACACCATAATTCTGGGCTACGGT
CACCAGTATCAGGCCAATACGGAAATAGAATATCTGTCTAACTGGATTGTATGGCGGGAAGCCGTACCAGACAGTACTTC
CCGCCACAAACGTCCTCCTCTGGAGGTTCTTAATAGTCAGTGTACTGTGATAGCTGGAGAGCGTAAAACCACAGTACTTC
CCCTGAGAGTGCTCAGCGATCTGACACCGGAATGCACAGAACAGGCTATATCGTTAAAAGATTATAAATTCATACTGAGA
GGGGGAAGCGGTGGGCTGGCTGTTCAGGTCGGTGGCGCGGGATATTATGATATTGATGCAAATCCTGTGGCAAAAGAAAA
TACGCTCTCTTTTCGCGGGCTACCGGAAGAGTTTCCGCTCGCCTTTGATTTATCAAAACAAACACAGTCGGTCATGCTGA
AAACAACGGACGGTGAGGTGCCGGTAATGACCATCACCCAGAAGGGAATAAACACCCTGGTCGGTACAACGGCCGGCGAA
AACTGGCTAACGGGTAACGATAAGGACAATACCTTCCATACGAGTTCTGGTGGCGGTACTGTCATCTCTGGTGGAGGGAA
TAACCGCTATATTATCCCCCGCGATTTAAAAACTCCGCTGACACTGACGCTGTCTAATAGCTCGGTCTCTCACGAGATCC
TTCTGCCAGAAACAACTCTGACAGAATTAAAACCTGTCGCCTTTGAGCTGAGTCTGATTTACTGGGCCGGGAACAATATA
AAGGTTCAGCTGGAGGATGAGACACAACTGAACCGTTTTGCCGGAAACTTCAGGGGGCATACCAGTGATGGCATTACTCT
GGAGGCGGTTTCCCAGGAAAATGGTATTCAACTGGGGGTTTCATCATGTGATGTTCAACGCTGGCAGGCTGTTTATCCGG
AAGAAAACAACAGACCAGACGCCATACTGGACAGGCTGCATGATATGGGATGGAGCCTGGCCCCCGAGGTCAGGTTCCGG
GGAGGAGAAACATCTGCCAGCTATGACCCCCTGAACCGTCAGCTCGTTTACCGGCTTCAGGAGCATTACTCGGAATTCAG
GCTGACCGGCAGTCGCCATTACACCACGGCTGTAACCGGAACCCCCGGAAGCCGGTACATTATTACGGGGCCGGATACAG
CACAGATATCACCGGCACAAATCATACTGGCCGGTGATAATGACCATCCGGAAACGATTGATTTGCTTGAGGCCAGTCCT
GTTCTGGTTGAAGGGAAAAAAGACAAAAACAGCGTGATATTAACGATTGCTACGATTCAGTATTCCCTTCAACTGACAAT
ATCCGGGATCGACGAATCGCTGCCCGGGACAACCCGTGTGGCAATTCAGCCTCAGGATACCCGTTTACTGGGTGACGTAC
TCCGGATCTTACCAGATAATGGTAACTGGGTGGGGATTTTCCGGAGTGGTCATACACCAACGGTAAACCGGCTGGAAAAT
TTGATGGCACTGAATCAGGTAATGACGTTCCTGCCCCGGGTATCCGGAAGTGCAGAGCAGGTATTATGCCTCGAAAACCT
AGGTGGCGTAAGGAAAAAAGTGGAGGGGGAGTTACTGTCAGGGAAGCTGAAAGGTGCGTGGAAAGCCGAAGGTGAACCTA
CTGTTCCGGTAAATATCTCAGATCTAAGTATCCCACCCTATTCACGTCTGTATCTGATTTTTGAAGGGAAAAATAATGTG
TTGCTACGCAGTAAAGTACATGCAGCTCCGTTGAAAATAACATCCGCAGGAGAGATGCAGTTATCTGAAAGGCAGTGGCA
ACAGCAGGAACATATTATTGTCAAGCCCGACAACGAAGCCCCCTCATTAATACTCAGTGAATTTCGTCGTTTCACTATTT
CATCGGATAAAAAATTTTCTTTAAAACTGATGTGCCATCAGGGGATGGTCCGCATCGACCGCAGATCATTATCGGTCAGA
TTGTTCTATCTGCGTGAACAGCCAGGTATCGGCAGTTTACGTCTGACGTTCAGAGATTTTTTCACAGAAGTGATGGATAC
AACGGACAGGGAAATTCTGGAGAAAGAGCTGAGACCAATTCTGATAGGAGATACACACCGCTTTATCAACGCTGCATACA
AAAATCATCTGAATATCCAGTTAGGAGATGGCGTTCTGAATCTGGCAGACATTGTTGCGGAATACGCCCGTATTCAAAAG
GAAGAAACATCAAAAATATTGTATCAATATCAAGGTGCCATGAAAAAAAAAACAGATGGACCATCTGTGGTAGAAGATGC
CATTATGACCACTACTGTCACAACAGATTCAGGTGAACCATTCCCTACCTTCCACCCGTGGTATACAGATGATTTATCAG
GGCGTTATAAGAGCGTACCTATGGCAAGAAAAGCAGATACTTTGTATCACCTGACACCAAAAGGTGATCTACAGATAATA
TATCAGGTAGCTACAAAAATGGTGAATCAGGCGATGATTGTATCCCTGCCAAACTACCGACACGAGTGGGAAAAATATAA
TTTAAGCATCTTATCCGAAATCCCTCAGAACAATAATACTGTTGTACATTCAATCCTCAGGGTTAATGGCCCCACAATGC
AGGTGCGCACAATTGACTACAGAGGAACGGATGAAAACAATCCCATAGTATCTTTTTCAGATACAACCTTCATCAATGGT
GAACAGATGTTGAGTTATGACTCGCATTCATCAGGGCGAGTCTATTCCAGAGAAGAATATATGATGTGGGAATTGCAGCA
ACGGGTATCAGAAGCTTCCAGTGCCCGGACACAGGATTACTGGCTGATGGATGCAGCGGTAAGAAACGGAGAATGGAAGA
TCACACCAGAATTATTACGTCACACACCGGGATATATCCGGAGTACGGTATCGAAATGGTCCAGAGGATGGCTGAAAACC
GGCACAATACTCCAGACTCCAGAAGACAGAAATACGGATGTATACCTGACTACCATACAGAACAATGTATTTAGTCGTCA
GGGGGGCGGCTACCAAGTGTATTATCGGATTGATGGAATGGCTGGTGCGGATATAGCGGATAATGCACCAGGGGAAACCC
GCTGCACCCTCAGGCCCGGAACATGTTTTGAAGTGACAAGTGTGGATGAAAGGCATTATGAGTGGAATATCATTTATGTC
ACGCTGAAAACCTGTGGCTGGAGCCGAAATGGCCAAAGCAAAACGCCGAATGGTGACAACCTTTTTAACTAA

Protein sequence :
MRLPEKVLFPPVTSGLSGQEKQKKPKSITGFQENYQRNIRPIKTASEARLRFFDKMVSKENSLEDVVSLGEMIQKEIYGH
EQRTFSPVHHTGNWKSSLLHNALLGLANVYNGLRETEYPNTFNRDGIKSTNSFRDNLLTKTRTPRDNFEEGIKHPEHATI
PYDNDNESNKLLKAGKIAGNNNELLMEIKKESKSDHQIPLSDKFLKRKKRSPVAEDKVQNSLTPENFVQKISLSDELKTK
YANEIIEIKRIMGEYNLLPDKNSRNGLKLLQKQADLLKIIMEDTSVTENIFKNIEMAIADIKKEYYSHTVDIEKNIHAIW
VAGSPPESISDYIKTFLKTYKEFTYYLWVDEKAFGAAKFTSVLKQIAFDLACRTIQQNTPQKNIDFINLYNEIRKKYNNN
PSGQQEYLNKLRELYATYQKISTPLKHMFNSFFLENMIKLQDNFFNYCIVKGVTEINDELRINYLKNVIKLSDDDIGNYQ
KTINDNKDRVKKLILDLQKQFGENRISIKDVNSLTSLSKSENNHNYQTEMLLRWNYPAASDLLRMYILKEHGGIYTDTDM
MPAYSKQVIFKIMMQTNGDNRFLEDLKLRRAISDGVLRYVNNQNIDEVNYNEISDADKNIIKKILTEISKMPEDSIFTKI
NTRIPRDTMPILRRYHLWPDGWNIRGLNGFMLSHKGSEVIDAVIAGQNQAYRELRRIRDNIHSEIYFKQTDELSSLPDTD
KIGGILVKKYLSGSLFSKFRQDTIIPEALSTLQISGPDLIQRKMLQFFRSRGVLGEEFINERKLSDKAYIGVYKTTGTGK
YDWLNPESIGVNDVTPADESTWCIGKGRCVDDFLFKDVSKLKTENLPELFLTKIDTDTFFSQWSTKTKKDLQKKIQDLTV
RYNELIDSSTIDFKNLYEIDQMLHMIMLEMNDDIAKRSLFSLQVQIAEKIRRMTIPVDNIINIYPDLHKKNDNDLSMSIK
GFLASNPHTKINILYSNKTEHNIFIKDLFSFAVMENELRDIINNMSKDKTPENWEGRVMLQRYLELKMKDHLSLQSSQEA
NEFLEISTFIYENDFLREKIEAVKNKMNSHELYFEKIKKEQNTWQDLSTKEQKLQLIKALKEISGNTEKDSHYDRLLDAF
FKKHNENIHNKIQRIKDEFKEYSRVTIHNIDKVIFKGQTLDRLYHEGYVFSDINTLSRYTLHGLGITGVHTEENLLPAPS
SSLINILKEHYNEDEISAKLPLAYDYILNKKESSSIPVEILNKLSELPPHELLTPVLGQSVNPLGMGYSSDNGKITEQVI
VSGADGFDNPISGLIYTYLEDLYNIHVRMREGTLNSQNLRQLLENSVSSCFLTEQSINKLLSEAEKRPYQSLTEIHQHLT
GLPTIADATLSLLSVGLPGTGKLLRREQDYGRPPVTAIQDSTFVLPYNFKGIGFNDNIISSAPVVSSLHFIAEHAKYTLL
SWPEFYRHHAQRWFEMAKGYGSQNIDFHPQSLLVTQEGRCMGLALLYLQTEDTAHYSILQENLMTVSALHQTSNRDKLPL
SKDDNSLMTRTYSLIEMLQYQGNKYITNESLLHKTAWNQERITLLFNEKGVKRALISTPNHTLVLQQLEDIYRLTDPNFG
HADFLSPIDALKFIEAMIQLTPTLQEYYGLLNKDINKHIQVHYAESDMVWNKLLPENDAGLSTRIQHTTTDRLANLAEPV
AVAGISLPVKTLYDIGATLDGRRITSPPTSEQIPSLRLNGDVLNDYLSRTVLTPEQADNIRKILHTQGIRSGTRPIDPEM
IRGTQDDLVSSQTRLQRQATRVKQQLAGVLDTLQQHFQNIPRSSGRHLSVENIELADIGSGRFNLQIRDGETLHTTSVEV
PEVVSRFQKLSTMLSALPASGIMDFDLGMSVVGVVQYARLLQQGHEDSTLAKINLAMDIKQLSEATLGSMIQIAGNKFLN
TEGIQGFRLESAVAEGMRSVATRTGGTMGKALSASARVLELPVLETVLGTWNLYNSVIQLQQATSYSETMAARVQIAFDS
ISLGLTAASVAFPPLIIATGPIAAIGMGASSIARNVARKEERHTQWLEYKKFLTDGSKHIVVASPERGLLDFSGNKVFGK
MVLDLRQSPPLLHGESSFNADRKIGHRPDLGDWQIREKVGYANSISPYSSLAHGYANSKWPQTIPKIPSGEYDTIILGYG
HQYQANTEIEYLSNWIVWREAVPDSTSRHKRPPLEVLNSQCTVIAGERKTTVLPLRVLSDLTPECTEQAISLKDYKFILR
GGSGGLAVQVGGAGYYDIDANPVAKENTLSFRGLPEEFPLAFDLSKQTQSVMLKTTDGEVPVMTITQKGINTLVGTTAGE
NWLTGNDKDNTFHTSSGGGTVISGGGNNRYIIPRDLKTPLTLTLSNSSVSHEILLPETTLTELKPVAFELSLIYWAGNNI
KVQLEDETQLNRFAGNFRGHTSDGITLEAVSQENGIQLGVSSCDVQRWQAVYPEENNRPDAILDRLHDMGWSLAPEVRFR
GGETSASYDPLNRQLVYRLQEHYSEFRLTGSRHYTTAVTGTPGSRYIITGPDTAQISPAQIILAGDNDHPETIDLLEASP
VLVEGKKDKNSVILTIATIQYSLQLTISGIDESLPGTTRVAIQPQDTRLLGDVLRILPDNGNWVGIFRSGHTPTVNRLEN
LMALNQVMTFLPRVSGSAEQVLCLENLGGVRKKVEGELLSGKLKGAWKAEGEPTVPVNISDLSIPPYSRLYLIFEGKNNV
LLRSKVHAAPLKITSAGEMQLSERQWQQQEHIIVKPDNEAPSLILSEFRRFTISSDKKFSLKLMCHQGMVRIDRRSLSVR
LFYLREQPGIGSLRLTFRDFFTEVMDTTDREILEKELRPILIGDTHRFINAAYKNHLNIQLGDGVLNLADIVAEYARIQK
EETSKILYQYQGAMKKKTDGPSVVEDAIMTTTVTTDSGEPFPTFHPWYTDDLSGRYKSVPMARKADTLYHLTPKGDLQII
YQVATKMVNQAMIVSLPNYRHEWEKYNLSILSEIPQNNNTVVHSILRVNGPTMQVRTIDYRGTDENNPIVSFSDTTFING
EQMLSYDSHSSGRVYSREEYMMWELQQRVSEASSARTQDYWLMDAAVRNGEWKITPELLRHTPGYIRSTVSKWSRGWLKT
GTILQTPEDRNTDVYLTTIQNNVFSRQGGGYQVYYRIDGMAGADIADNAPGETRCTLRPGTCFEVTSVDERHYEWNIIYV
TLKTCGWSRNGQSKTPNGDNLFN