Name : cagA
Accession : BAC10435.1
PAI name : cag PAI
PAI accession : AB090089
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 48 hits ( 47 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAATAACACCAGATCAAACAGATTTTGTTCCGCAACGATTTATCAATAATCTTCA
AGTAGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATAAGAATGATAGGG
ATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAATCCCACCAAAAAG
AATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGT
AGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCTTCTAAAA
TCAACACCCAACAAATCCGAGATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAGAAAGCGGAGTTT
TTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATGAAAAATTCATGGGCGTGTT
TGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTAT
CATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAAT
TTAGCTACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGGTAATTTTTTTAA
ATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGTGTCGCTGACAAGGATCCCAATTACAAGTTCAATCAGTTAT
TGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGGGTCATAGCAACATAGAACCTGAAAAAGTTTCATTATTGTAT
GGAGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAGTAATGTGGC
CACACTCATTAATGCGCATCTTCATAACGGTAGTGGGTTAGTCATAGCGGGTAATGAGGATGGGATTAAAAACCCTAGCT
TCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCAATGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTC
ATGGAATTTCTTGCAAAAAACAACGCTAAACTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAACTGAGATTGG
AAATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAA
AACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAATTGAGCTATACCCTCAAAGATTATGGGAAAAAACAAGATAAA
GCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAATTATTCCAATTT
CAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGTGCTACGAATGGCGTTTCCCATTTGGAAGCAAATTTTA
GCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAA
TTGTGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAGGGATTGGTTGG
AAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAAAAGCTCAGAAAG
ATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGAAACGACAACAAA
AATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGAGGCTAGTAAGGA
AGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAAATATCAACAAGA
ATTTGAAAGACTTTGGCAAATCTTTTGACGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGTAGAAGAAACGCTA
AAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTT
GAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGG
ATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAATTAACAGGCGAT
TTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATC
CGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTT
CGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAGTAATGGACTCAAAAACAGCACAGAG
CCTATTTATGCTCAAGTCAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCTAA
AAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTG
CATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGAT
TTTGATGAGACAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAG
GGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGGCAACCTAG
AACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGTTATGGGTTGAAAGCGCGAAACAAGTGCCT
ACTGGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAACATGGAGCAAT
CAATGAAAAAGCGACTGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATA
ATGTGGGAAGCACTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTC
AAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTAC
AGGAGCTTACAACTTGATGAAGGCAAATGTGGAACATGGAGTCAAAAACACTACAAAAGGTGGTTTCCAAAAATCTTAA
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| Protein sequence : | |
MTNETIDQTITPDQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKNPTKK
NQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRDFMENIIQPPISDDKEKAEF
LRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQN
LATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKVSLLY
GDNGGPEARHDWNATVGYKNQQGSNVATLINAHLHNGSGLVIAGNEDGIKNPSFYLYKEDQLTGLKQAMSQEEIQNKVDF
MEFLAKNNAKLDNLSEKEKEKFQTEIGNFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGELSYTLKDYGKKQDK
ALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSPQEANKLIKDFLNSNKGLVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNK
NRMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKVEETL
KALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETKLTGD
FSKVEQALAELKNLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNSNGLKNSTE
PIYAQVNKKKTGQVASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATID
FDETNQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVP
TGLQAKLDNYATNSHTRINSNVQHGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSTHLSEYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGAYNLMKANVEHGVKNTTKGGFQKS
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