Name : cagA
Accession : BAC10433.1
PAI name : cag PAI
PAI accession : AB090087
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 48 hits ( 47 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCAGATCAAACACCAAATCAAACAGATTTTGTTCCGCAACAATTTAT
CAATAATCTTCAGGTAGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTTATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATTTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGAAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACAACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGTGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAGTTATTGATCCACAATAACGCTCTGTCTTCTATGCTAATGGGGAGTCATAATAACATAGAACCTGAAAAAGTT
TCATTATTGTATGGGGATAATGGTGGTCTTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTA
ACAACCCTAGTTTTTATCTCTATAAAGAAGACCAACTCACAGGCTTGAAACAAGCAATGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCACGAAACAATGCTAAACTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAATATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAA
TTATTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGCGTGGGCGCTACGAATGGCGTTTCCCATTTGG
AGGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTACCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTGGGCTAGAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAAATGGTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGA
GGCTAGTAAGGAAGCAAGAGCGGTCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAGCAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTGAAACAGACGCCACAACGCTCA
CCAAAAATTTTTCGGATATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACAACACAGAGCCTATTTATGCTCAAGTCAATAAAAAGAAAACAGGACAAGCAGCTAGCCCTGAAGAGCCCATTTACGC
TCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCGGCAATAAATAGAAAAATTGACCGGA
TTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGCTTTCAGTGGAGCAAGGCAATCAGCTAGCCCTGAACCCATTTAC
GCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTCCAGTTAATGTTCTCAGTAAAGT
AGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAGTCAGGCAGTGTCAGAAGCTAAAACAGGTCATT
TTGACAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCA
AAACAAGTGCCTATTGGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCA
AACTGGAACAATCAATGAAAAAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGA
TAGTTGCGCATAATGTGGGAAGCGCTCCTTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTAT
TCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAA
TACATTTTCTACAGGATCTTACAACTTGATGAAAGCAAATGCGGAACATGGAGTCAAAAATACTAATACAAGCGGAACAT
GGAGTCAAAAATACTAA
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| Protein sequence : | |
MTNETIDQTTTPDQTPNQTDFVPQQFINNLQVAFLKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDEFLKERQEAEKNEEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSMLMGSHNNIEPEKV
SLLYGDNGGLEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQAMSQEEIQN
KVDFMEFLARNNAKLDNLSEKEKEKFQTEIEYFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPNKGVGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLWARGLSPQEANKLIKDFLNSNKEMVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINQEASKEARAVAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LAGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSETDATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NNTEPIYAQVNKKKTGQAASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGAFSGARQSASPEPIY
ATIDFDEANQAGFPLRRSAPVNVLSKVGLSREQELTRRIGDLSQAVSEAKTGHFDNLEQKIDELKDSTKKNALKLWVESA
KQVPIGLQAKLDNYATNSHTRINSNVQTGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAPLSEYDKIGFNQKNMKDY
SDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYNLMKANAEHGVKNTNTSGTWSQKY
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