Name : cagA
Accession : BAC10432.1
PAI name : cag PAI
PAI accession : AB090086
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 46 hits ( 45 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACACCAAGCCAAACAGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGTAGC
TTTTCTTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATAACA
GGCAAGCTTTTGAGAAAATCTCGCAACTAATGGAGGAATTCGCTAATAAAGCGATCAAAAATCCTGCCAAAAAGAATCAG
TATTTTTCAAACTTTATCAGTAAGAGCAATGATTTAATCAACAAAGACAGTCTCATTGATATAGGTTCTTCCACAAAGAG
CTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCATCTAAAATCAACA
CCCAAAGAATCCGAAGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGTTTTTGAGG
TCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAGATCCAATCAGATCAAAAATTCATGGGCGTGTTTGAAGA
ATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGAGAGCCTACTGGTGGGGATTGGCTTGATATTT
TTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTTAAAGAAACACTAAATCAAGAACCAGTTCCTCATGTCCAA
CCAGATATAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGGTAATTT
TTCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGCGTCGCTGATATTGATCCTAATTACAAGTTCAACC
AATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTA
TTGTATGGGGGCAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCGACAA
TGTGGCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACAACC
CTAGTTTTTATCTCTACAAAGAAGACCAGCTCACAGGCTTGAAACAAGCATTGAGCCAAGAAGAGATCAAAAACAAAGTA
GATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGATAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAATGA
GATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAG
ACAAAAAACATTTAGCTTTAGTTGCTGAGTTTGGTAATGGGGAATTGAGCTACACTCTCAAAGATTATGGGAAAAAACAA
GATAAAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTTAATTATTC
TAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCTGTTTCCCTTTGGAAGCAA
ATCTTAGTAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATATAAGGCGAGACTTAGAA
GATAAACTGTGGGCTAAAGGATTGTCCCCACAAGAAGTTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAATT
GGTTGAAAAAGCTTTAAACTTCAATAAAACTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAGCTC
AGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAACGAAAAAATTGGAGAGAAAAAGCGAT
AACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCAATTATCAATGAAGAGGCTGG
TAAGGAAGCAAGAGTAGCCGCTTGCGTTCAGAATCTTAAAGGCATCAGAATGGAATTGTCTGATAAGCTTGAAAACATCA
ACAAGAATTTGAAAGACTTTGATAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGACAGAAGAA
ACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATAC
AGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCCA
TTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCTGTATCAATAGCTAAAGAAACG
GGTGATTTCAGTAGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTTCTCAAAAGGGCAATTGACTCAACAAGCTCAAAA
AAATGAAGATTTCAATACTGGAAAAAATTCTAAACTATACCAATCCGTTAAGAATGGTGTAAATGGAACCCTAGTCGGTA
ATGGGTTATCTGGAATAGAGGCCACAGCTCTCGCCAAAAAATTTTCGGATATCAAGAAAGAATTGAATGAGAAATTTAAA
AATTTCAACAACAATAACAATAATGGACTCAAAAACGAACCCATTTATGCTGAAGTTAATAAAAAGAAAACAGGACAAGT
AGCTAGCCCTGAAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAAAGCAAAAATTGACCGACTCGATCAAATAGCAA
GTGGTTTGGGTGGTGTAGGGCAAGCGGGGTTCTCTTTGAAAGGGCATACTAAAGTTGATGATCTCAGTAAGGTAGGGCTT
TCAGCTAACCATGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAAGCATACTAAAGTTGA
TGATCTCAGTAAGGTAGGGCTTTCAGCTAACCATGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTT
TGAAAAAGCATACTAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAGCTAACCATGAACCCATTTACGCTACGATTGAT
GATCTCGGCGGACCTTTCCCTTTGAAAAAGCATGATAAAGTTGGTGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAAGA
ATTGAAACAAAAGATTGACAATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGACAACCTAGATCAAATGA
TAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATGAATCTATATGTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTG
TCAGCGAAATTGGACGATTATGCTACTAACAGCCACACACGCATTAATAGCAATGTCAAAAATGGAGCAATCAATGAAAA
AGCGACTGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAA
GCGCTTCTTTGTCAGAGTATGATAAAATTGGCTTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCC
ACCGAGTTGAACAATGCTATAAAAGACATTAAGTCTGGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGCATCTTA
TTACTGCTTGGCGGAAGAAAATGCGAAGCATGGAATCAAAAATGCTAATACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTPSQTAFNPQQFINNLQVAFLKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLMEEFANKAIKNPAKKNQ
YFSNFISKSNDLINKDSLIDIGSSTKSFQKFGTQRYQIFMNWVSHQKDPSKINTQRIRSFMENIIQPPISDDKEKAEFLR
SAKQSFAGIIIGNQIQSDQKFMGVFEESLKERQEAEKNGEPTGEPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPVPHVQ
PDIATTTTDIQSLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSL
LYGGNGGPEARHDWNATVGYKNQQGDNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQEEIKNKV
DFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKKQ
DKALDRETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPDKGVGATNGCFPLEANLSKVAVFNLPNLNNLAITSYIRRDLE
DKLWAKGLSPQEVNKLIKDFLNSNKELVEKALNFNKTVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVTKKLERKSD
NKNRMEAKAQANSQKDKIFAIINEEAGKEARVAACVQNLKGIRMELSDKLENINKNLKDFDKSFDEFKNGKNKDFSKTEE
TLKALKDSVKDLGINPEWISKVENLNTALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSIAKET
GDFSRVEQALADLKNFSKGQLTQQAQKNEDFNTGKNSKLYQSVKNGVNGTLVGNGLSGIEATALAKKFSDIKKELNEKFK
NFNNNNNNGLKNEPIYAEVNKKKTGQVASPEEPIYTQVAKKVKAKIDRLDQIASGLGGVGQAGFSLKGHTKVDDLSKVGL
SANHEPIYATIDDLGGPFPLKKHTKVDDLSKVGLSANHEPIYATIDDLGGPFPLKKHTKVDDLSKVGLSANHEPIYATID
DLGGPFPLKKHDKVGDLSKVGLSREQELKQKIDNLNQAVSEAKTGHFDNLDQMIDKLKDSTKKNVMNLYVESAKKVPTSL
SAKLDDYATNSHTRINSNVKNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSASLSEYDKIGFNQKNMKDYSDSFKFS
TELNNAIKDIKSGFVQFLTNTFSTASYYCLAEENAKHGIKNANTKGGFQKS
|
|
