Name : cagA
Accession : BAC10431.1
PAI name : cag PAI
PAI accession : AB090085
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 48 hits ( 47 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCAGATCAAACAGATTTTGTTCCGCAACGATTTATCAATAATGCTCA
AGTAGCTTTTATTGAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATAAGAATGATAGGG
ATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAATCCTACCAAAAAG
AATCAGTACTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGT
AGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCGTCTAAAA
TCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAAAAAGCGGAGTTT
TTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATTCATGGGCGTGTT
TGATGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTAT
CATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAAT
TTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGGTAATTTTTTTAA
ATTCACTCTTGGTGATGTGGAAATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCTAATTACAAGTTCAATCAATTAT
TGATCCACAATAACGCTTTATCTTCTGTGCTAATGGGGAGTCATAGCAGCATAGAACCTGAAAAAGTTTCATTATTGTAT
GGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCTACTGTTGGTTATAAAAACCAACAAGGCAACAATGTGGC
CACACTCATTAATGCGCATCTTAATAACGGCAGCGGGTTAGTCATAGCGGGTAATGAGGATGGGATTAAAAACCCTAGCT
TCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCAATGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTC
ATGGAATTTCTTGCAAAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAACTGAGATTGG
AAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCCCTAGGGAATGATCATGTTGCTTCTGTTTCTAAAAAAGACCCAA
AACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAAAAACAAGATAAA
GCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAATTATTCCAATTT
CAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGTGCTACGAATGGCGTTTCCCATTTGGAGGCAAATTTTA
GCAAGGTAGCTGTCTTTAATTTACCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAA
TTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAATTGCTTGG
AAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAGGCTCAGAAAG
ATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGAAACGACAACAAA
AATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCGTTGATCAATCAAGAGGCTAGTAAGGA
AGCAAGAGCGGCTGCTTTCGATCCGAATCTTAAAGGCATCAGGAACGAATTGTCTGATAAACTTGAAAATATCAACAAGA
ATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAACAAGGCAGAAGAAACGCTA
AAAGCCCTTAAAGACTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTT
GAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGG
ATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAATTAACAGGCGAT
TTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATC
CGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTT
CGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAGCACAGAG
CCTATTTACGCTAAAGTTAATAAAAAGAAAGCAGGACAAGCAGCTAGCCCTGAAGAGCCTATTTACGCTCAAGTTGCTAA
AAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTG
CATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGAT
TTTGATGAGACAAATCAAGCAGGCTTCCCTCTTAGGAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAG
GGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGACAACCTAG
AACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGTTATGGGCTGAAAGCACGAAACAAGTGCCT
ACTGGTTTGCAGGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAACATGGAACAAT
CAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATA
ATGTGGGAAGCGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTC
AAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTAC
AGGAGCTTACAACTTGATGAAGGCAAATGTGGAACATGGAGTCAAAAACACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTPDQTDFVPQRFINNAQVAFIEVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKNPTKK
NQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKEKAEF
LRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKERQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQN
LATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSSIEPEKVSLLY
GDNGGPEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLVIAGNEDGIKNPSFYLYKEDQLTGLKQAMSQEEIQNKVDF
MEFLAKNNAKLDNLSEKEKEKFQTEIGNFQKDRKAYLDALGNDHVASVSKKDPKHLALVTEFGNGEVSYTLKDYGKKQDK
ALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LLAKGLSPQEANKLIKDFLNSNKELLGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNK
NRMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRNELSDKLENINKNLKDFGKSFDELKNGKNNDFNKAEETL
KALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETKLTGD
FSKVEQALAELKNLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNSTE
PIYAKVNKKKAGQAASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATID
FDETNQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFDNLEQKIDELKDSTKKNALKLWAESTKQVP
TGLQAKLDNYATNSHTRINSNVQHGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGAYNLMKANVEHGVKNTTKGGFQKS
|
|
