Name : cagA
Accession : BAC10430.1
PAI name : cag PAI
PAI accession : AB090084
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 45 hits ( 44 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCAGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTGGCTTTTATCAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCTGCCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAATCAAATCCGATCGGATCAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGAAGAGCCTACTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTTTATCTTCTGTGCTAATGGGGAGTCATAGCAACATAGAACCTGAAAAAGTT
TCATTATTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACTGTTGGTTATAAAGACCAACAAGG
CAACAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGTAGCGGGTTAATCATAGCGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTCTATCTCTACAAAACAGACCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCAAAAAACAACGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAAATTTTCAAAAAGACCGTAAGGCTTATTTAGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTTGA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTAAACAGCAACAA
AGAATTGCTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATAAAGA
GGCTAGTAAGGAAGCAAGAGCAGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATTAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACAACACAGAGCCTATTTATGCTCAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGC
TCAAGTTGCCAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTGCATCAGCTAAAAATGGTGTAAATGGAACCC
TAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTTCGGACATTAGGAAAGAATTGAACGAG
AAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAACACAGAGCCTATTTATGCTCAAGTTAATAAAAA
GAAAACAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCCAAAAAGGTGAGTGCAAAAATTGACCAAC
TCAACGAAGCTGCATCAGCAATAAATAGAAAAATTGACCGGATTAACGAAATTGCATCAGCAGGTAAAGGAGTGGGCGGT
TTCAGTGGAGCAAGGCAATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGATGATGCAAATCAAGCAGGCTT
CCCTTTGAGAAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTG
GCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGGCAACCTAGAACAAAAGATAGATGAACTCAAAGAT
TCTACGAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCGAAACAAGTGCCTACTAGTTTGCAAGCGAAATTGGACAA
TTACACTACTAACAGCCACACACGCATTAATAGCAATGTCCAAACTGGAACAATCAATGAAAAAGCGACCGGTATGCTGA
CACAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGTGCTCATTTGTCAGAG
TATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGC
CGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGAGCTTACAGCTTGATGAAAGCAA
ATGCGGAACATGGAGTCAAAAATACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PAKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDQKFMGVFDESLKARQEAEKNEEPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKDQQGNNVATLINAHLNNGSGLIIAGNEDGIKNPSFYLYKTDQLTGLKQALSQEEIQN
KVDFMEFLAKNNAKLDNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVDYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLLAKGLSPQEANKLIKDFLNSNKELLGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINKEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NNTEPIYAQVNKKKTGQVASPEEPIYAQVAKKVSAKIDQLNEAASAKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNE
KLFGNSNNNNNGLKNNTEPIYAQVNKKKTGQVASPEEPIYAQVAKKVSAKIDQLNEAASAINRKIDRINEIASAGKGVGG
FSGARQSASPEPIYATIDFDDANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFGNLEQKIDELKD
STKKNALKLWVESAKQVPTSLQAKLDNYTTNSHTRINSNVQTGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSE
YDKIGFNQKNMKDYSDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGAYSLMKANAEHGVKNTTKGGFQKS
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