Name : cagA
Accession : BAC10428.1
PAI name : cag PAI
PAI accession : AB090082
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 46 hits ( 45 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGACCAACAACCACAAACCGAAGTGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
AGCTTTTCTTAAGCTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAACGATAGGGATA
ACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACTCCAATAAAGCGATCAAAAATCCTGCCAAAAAGAAT
CAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGTAGA
GAGCTTTCAGAAATTTGGGGATCAGCGTTACCAAATTTTCACAAGTTGGGTGTCCCTTCAAAACGATCCGTCTAAAATCA
ACACCCGATCGATCCGAAATTTTATGGAACATACCATACAACCCCCTATCCCTGATGACAAAGAAAAAGCAGAGTTTTTG
AAATCTGCCAAGCAATCTTTTGCAGGAATCATTATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGACGTGTTTGA
TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTGCTGGTGGGGATTGGTTGGATATTTTTCTCTCAT
TTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTCCCCATGTTCAACCAGATATA
GCCACTACCACCACCGACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCTAATTACAAGTTCAATCAATTATTGA
TTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCG
GGCAATGGTGGTTTTGGAGCCAAGCACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTAC
AATAATTAATGTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAACAACCCTAGTTTTT
ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTAAGTCAAGAAGAGATCCAAAACAAAATAGATTTCATG
GAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTTCAAACTGAGATTGAATA
TTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACCCAAAAC
ATTCAGCTTTAATTACTGAGTTTGGTAATGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCT
TTAGATAGGGAGAAAAATGTTACTCTTCAAGGTAACCTAAAATATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAATCCCAATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTAGACGCAGGCTTTAACA
AGGTAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA
ACCACTAAAGGATTGTCCCTACAAGAAGCTAATAAGCTTATCAAAGATTTTTTGAGCAGCAACAAAGAATTGGTTGGAAA
AGCTTTAAACTTCAATAAAGCTGTAGCTGACGCTAAAAACACAGGCAACTATGACGAGGTGAAAAAAGCTCAGAAAGATC
TTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGAGAAAAAATTGGAGAGCAAAAGCGGCAACAAAAAT
AAAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATGAGATTTTTATGTTAATCAATAAAGAGGCTAATAGGGACGC
AAGAGCAATCATTTGCGCTCAAAATCTTAAAGGCATCAGAAGGGAATTGTCTGATAAACTTGAAAATGTCAACAAGGATT
TGAAAGACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACACTAAAA
GCCCTTAAAGGCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCCATTAAAGATG
CGATCTTCAATCAAAAGATAACGGATAAAGTTGATGATCTCAATCAAGCGGTATCAGTGGCTAAAGCAACGGGTGATTTC
AGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAGGAGCAATTGGCTCAACAAACTCAAAAAAATGAAAG
TTTCAATGTTGGAAAAAAATCTGAAATATATCAATCCGTTAAGAATGGTGTGAACGGAACCCTAGTCGGTAATGGATTAT
CTGGAATAGAGGCCACAGCTCTCGCCAAAAATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTATTTGGAAATTCC
AATAACAATAATAATGGACTCAAAAACAGCACAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGC
TAGCCATGAAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTG
GTTTGGGTGGTGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCGA
TCAGCTAGCCCTGAACCCATTTATGCTACAATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGA
TGATCTCAGTAAGGTAGGGCGATCAGCTAGCCCTGAACCCATTTATGCTACAATTGATGATCTCGGCGGACCTTTCCCTT
TGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGGGGCAAGAATTGGCTCAGAAAATTGACAAT
CTCAATCAGGCGGTATCAGAAGCTAAAGCAGGTTATTTTGGCAACCTAGAACAAAAGATAGACAAGCTCAAAGATTCTAC
AAAAAACAATACTGTGAATCTATGGCTTGAAAGTGCAAAAAAAGTGCCTGCTAGTTTGTCAGCGAAATTGGACAATTACG
CTACTAACAGCCACACACGCATTAATAGCAATATCCACAATGGAGCAATCAATGAAAAAGCGACCGGTATGCTAACGCAA
AAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTAGGAAGCGTTCCTTTGTCAGAGTATGA
TAAAATTGGCTTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAGGTTTTCCACCAAGTTGAACAATGCTGTAA
AAAACGTTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTACAGGATATTACAGCTTGGCGGGAGAAAATGCG
GAGCATGGAATCAAAAATGTTAATACAAAAGGTGGTTTCCAAAAATCTTAA
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| Protein sequence : | |
MTNETIDQQPQTEVAFNPQQFINNLQVAFLKLDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYSNKAIKNPAKKN
QYFSDFINKSNDLINKDNLIAVDSSVESFQKFGDQRYQIFTSWVSLQNDPSKINTRSIRNFMEHTIQPPIPDDKEKAEFL
KSAKQSFAGIIIGNQIRTDQKFMDVFDESLKERQEAEKNGEPAGGDWLDIFLSFIFDKKQSSDVKEAINQEPVPHVQPDI
ATTTTDIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYA
GNGGFGAKHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKIDFM
EFLAQNNAKLDNLSEKEKEKFQTEIEYFQKDSKAYLDALGNDRIAFVSKKDPKHSALITEFGNGDLSYTLKDYGKKADKA
LDREKNVTLQGNLKYDGVMFVDYSNFKYTNASKNPNKGVGATNGVSHLDAGFNKVAVFNLPDLNNLAITSFVRRNLEDKL
TTKGLSLQEANKLIKDFLSSNKELVGKALNFNKAVADAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKSGNKN
KMEAKAQANSQKDEIFMLINKEANRDARAIICAQNLKGIRRELSDKLENVNKDLKDFSKSFDEFKNGKNKDFSKAEETLK
ALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDAIFNQKITDKVDDLNQAVSVAKATGDF
SRVEQALADLKNFSKEQLAQQTQKNESFNVGKKSEIYQSVKNGVNGTLVGNGLSGIEATALAKNFSDIKKELNEKLFGNS
NNNNNGLKNSTEPIYAKVNKKKTGQVASHEEPIYTQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKRHDKVDDLSKVGR
SASPEPIYATIDDLGGPFPLKRHDKVDDLSKVGRSASPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSRGQELAQKIDN
LNQAVSEAKAGYFGNLEQKIDKLKDSTKNNTVNLWLESAKKVPASLSAKLDNYATNSHTRINSNIHNGAINEKATGMLTQ
KNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFNQKNMKDYSDSFRFSTKLNNAVKNVKSGFTQFLANAFSTGYYSLAGENA
EHGIKNVNTKGGFQKS
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