Name : cagA
Accession : BAC10427.1
PAI name : cag PAI
PAI accession : AB090081
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 46 hits ( 45 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCGGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAATAGGCAAGCTTTTGAGAAAATCTCGCAACTAATGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTTAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCAGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAGCAAAATATAGCCACTACCACCACCAGCATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGCGGAGATGTTGGATGTTGAGGGTGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTGTCTTCTGTGCTAATGGGGGGTCATAGTAACATAGAACCTGAAAAAGTT
TCGTTATTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAGTAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGCAGTGGGTTAGTCATAGCGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCAAAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAAATTGGAAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCTCTGGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACAACTCAACGCTTCCAAGAGTCCTGATAAGGGCGTTGGGCGCTACGAATGGCGTTTCCCATT
TGGAAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGA
GATTTAGAAGATAAATTGTGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAA
CAAAGAATTGCTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGGATCTAAAAATACAGGCAATTATGATGAAGTGA
AAAAAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGC
AGAAACGAAAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCGTTGATCAATCA
AGAGGCTAGTAAGGAAGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCGTCAGGAGCGAATTGTCTGATAAACTTG
AAAATATCAATAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGATTTCAAAAATGGCAAAAATAATGATTTCAGCAAG
GCAGAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAA
CCTTAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTG
AAAATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACT
AAATTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTC
TGATCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGC
TCACCAAAAATTTTTCGGATATCAGGAAAGAATTGAACGAGAAATTATCTGGAAATTCCAATAACAATAATAATGGACTC
AAAAACAACACAGAGCCTATTTACGCTCAAGTTAATAAAAAGAAAACAGGACAAGCAACTAGCCCTGAAGAGTCCATTTA
CGCTCAAGTTGCTAAAAAGGTGAGTGTAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACC
GGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAACTAGCCCTGAAGAGTCC
ATTTACGCTCAAGTTGCTAAAAAGGTGAGTGTAAAAATTGACCAACTCAGCGAAGCTACATCAGCAATAAATAGAAAAAT
TGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAAC
CCATTTACGCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGAGGTGCTAAAGTTGGTGATCTC
AGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAAT
AGGTCATTTTGGCAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTGTGAAGTTATGGGTTG
AAAGTGCGAAACAAGTGCCTACTGGTTTGCAGGCGAAATTGGACAATTATGCTACTAACAGCCACACACGCATTAATAGC
AATGTCCAAGATGGAGCAATCAATGAAAAAGCGACCGGTGTGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAG
TGATAAGATAGTTGCGCATAATGTGGGAAGCGCTCCTCTGTCAGATTATGATAAAATTGGATTCAACCAAAAGAATATGA
AAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACACTAAGTCTAGCTTTGTGCAATTT
TTAACCAATACATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAATACTACAAAAGG
TGGTTTCCAAAAATCTTAA
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| Protein sequence : | |
MTNETIDQTTTPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLMEEYANKAIKN
PTKKNQYFLDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKERQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNIATTTTSIQGLPPEARDLLDERGNFFKFTLGDAEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGSNVATLINAHLNNGSGLVIAGNEDGIKNPSFYLYKEDQLTGLKQALSQEEIQN
KVDFMEFLAKNNAKLDNLSEKEKEKFQTEIGNFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVNYSNFKYNSTLPRVLIRALGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRR
DLEDKLWAKGLSPQEANKLIKDFLNSNKELLGKVSNFNKAVAGSKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLES
RNENKNRMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGVRSELSDKLENINKNLKDFGKSFDDFKNGKNNDFSK
AEETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSET
KLTGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLSGNSNNNNNGL
KNNTEPIYAQVNKKKTGQATSPEESIYAQVAKKVSVKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSTSPEES
IYAQVAKKVSVKIDQLSEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFDEANQAGFPLRRGAKVGDL
SKVGLSREQELTRRIGDLNQAVSEAKIGHFGNLEQKIDELKDSTKKNAVKLWVESAKQVPTGLQAKLDNYATNSHTRINS
NVQDGAINEKATGVLTQKNPEWLKLVSDKIVAHNVGSAPLSDYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDTKSSFVQF
LTNTFSTGSYSLMKANVEHGVKNTTKGGFQKS
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