Name : cagA
Accession : BAC10426.1
PAI name : cag PAI
PAI accession : AB090080
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 48 hits ( 47 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAAATCAAACAGATTTTGTTCCGCAACGATTTATCAATAATCTTCAAGTAGC
TTTTCTTAAAGTTGGTGACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATAACA
GGCAAGCTTTTGAAAAAATCTCGCAACTAAGGGAAGAATACGCTAATAAAGCGATCAAAAATCCCACCAAAAAGAATCAG
TATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGTAGAGAG
CTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCGTCTAAAATCAACA
CCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGTTTTTGAGG
TCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGATCGGATGAAAAATTCATGGGCGTGTTTGATGA
ATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTATCATTTG
TGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAATTTAGCC
ACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTTTAAATTCAC
TCTTGGTGATATGGAAATGTTGGATGTTGAGGGAGTCGCTGATAAGGATCCCAATTACAAGTTCAATCAATTATTGATTC
ACAATAACGCTCTGTCTTCTGTGCTAATGGGGGGTCATAGTAACATAGAACCTGAAAAAGTTTCATTATTGTATGGGGAT
AATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTATAAAGACCAACAAGGCAGTAATGTGGCCACACT
CATTAATGCGCATCTTAATAACGGCAGTGGGTTAATCATAGCGGGTAATGAGGATGGGATTAAAAACCCTAGCTTCTATC
TCTACAAAGAAGATCAACTCACAGGCTTGAAGCAAGCAATGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTCATGGAA
TTTCTTGCACAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAAATGAGATTGAAGATTT
CCAAAAAAACCGTAAGGCTTATTTGGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAAAACATT
TAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAAAAACAAGATAAAGCTTTA
GATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAATTATTCCAATTTCAAATA
CACCAACGCCTCCAAGAGTCCTGATAAGGGCGTGGGCGCTACGAATGGCGTTTCCCATTTGGAAGCAAATTTTAGCAAGG
TAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAACTGTTG
GCTAAAGGATTGTCCCCACAAGAAACTAATAAGCTCATCAAAGACTTTTTAAACAGCAACAAAGAATTGGCTAGAAAACT
TTCAAACTTCAATAAAGCTGTAACTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAAAAGCTCAGAAAGATCTTG
AAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAACGAAAAAATTGGAGAGCAGAAACGACAACAAAAATAGA
ATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGAGGCTAGTAAGGAAGCAAG
AGCGACCGCTTTCGATCCGAATCTTAAAGGCGTCAGGGGCGAATTGTCTGATAAACTTGAAAATATCAACAAGAATTTGA
AAGACTTTGGCAAATCTTTTGATGAACTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTAAAAGCC
CTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTTGAATGA
TTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGGATGTGA
TCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAATTAACAGGCGATTTCAGT
AAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATCCGTTAA
AAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTTCGGACA
TCAGAAAAGAATTGAACGAGAAGTTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAATAGTGCAGAGCCCATT
TACGCTCAAGTTAATAAAAAGAAAGCAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCTAAAAAGGT
GAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAG
CAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGAT
GAGGCAAATCAAGCAGGCTTCCCTTTGAGGAGATACGCTGGATTTGATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACA
AGAATTGACTTGTAGAATTGGCGATCTCAATCAGGCGGTGTCAGAAGCTAAAACAGGTCGTTTTGACAACCTAGAACAAA
AGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCGAAACAAGTGCCTACTAGT
TTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAACAATCAATGA
AAAAGCGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGG
GAAGCGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTT
TCCACCAAGTTGAACAATGTTGTAAAAGACATTAAGTCTGGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGATC
TTACAGCTTGATGAAAGCAAATGCGGAACATGGAATCAAAAATACTACAAAAGGTGGTTTCCAAAAATCTTAA
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| Protein sequence : | |
MTNETIDQTTNQTDFVPQRFINNLQVAFLKVGDAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKNPTKKNQ
YFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKEKAEFLR
SAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQNLA
TTTTDIQGLPPEARDLLDERGNFFKFTLGDMEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKVSLLYGD
NGGPEARHDWNATVGYKDQQGSNVATLINAHLNNGSGLIIAGNEDGIKNPSFYLYKEDQLTGLKQAMSQEEIQNKVDFME
FLAQNNAKLDNLSEKEKEKFQNEIEDFQKNRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGKKQDKAL
DGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPDKGVGATNGVSHLEANFSKVAVFNLPDLNNLAITNYIRRDLEDKLL
AKGLSPQETNKLIKDFLNSNKELARKLSNFNKAVTEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVTKKLESRNDNKNR
MEAKAQANSQKDKIFALINQEASKEARATAFDPNLKGVRGELSDKLENINKNLKDFGKSFDELKSGKNKDFSKAEETLKA
LKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETKLTGDFS
KVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNSAEPI
YAQVNKKKAGQVASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFD
EANQAGFPLRRYAGFDDLSKVGLSREQELTCRIGDLNQAVSEAKTGRFDNLEQKIDELKDSTKKNALKLWVESAKQVPTS
LQAKLDNYATNSHTRINSNVQSGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDYSDSFKF
STKLNNVVKDIKSGFVQFLTNTFSTGSYSLMKANAEHGIKNTTKGGFQKS
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