Name : cagA
Accession : BAC10424.1
PAI name : cag PAI
PAI accession : AB090078
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 46 hits ( 45 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCAGATCAAACACCAAATCAAACAGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATCAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATATAGCCACTACCACCACCAGCATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGAGTCATAGCAGCATAGAACCTGAAAAAGTT
TCATTATTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAGTAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGCAGTGGGTTAGTCATAGCGGGTAATGAAAATGGGATTA
AAAACCCTAGCTTCTATCTCTACAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCAAAAAACAACGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAAATTTCCAAAAAGACCGTAAGGCTTACTTGGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTTGA
TTATTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGCGTGGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAAGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAAATGGTTGGAAAAGTTTTAAACTTCAATAAAGCTGTAGCTGGAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACAACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGA
GGCTAGTAAGGAAGCAAGAGCAGCCGCTTTCGATCCGAGTCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAAAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGCCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGTCCTAGCCGAACTCAAAAACTTGTCATTAGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACAACACAGAGCCTATTTATGCTCAAGTTAATAAAAAGAAAACAGGACAAGCAACTAGCCCTGAAGAGCCCATTTACGC
TCAAGTTGCCAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGA
TCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAA
TTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAACACAGAGCCTATTTATGCTCAAGTTAATAAAAAGAA
AACAGGACAAGCAACTAGCCCTGAAGAGTCCATTTACGCTCAAGTTGCCAAAAAGGTGAGTGCAAAAATTGACCAACTCA
ACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTC
AGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGATGAGGCCAATCAAGCAGGATTCCC
TCTTAGGAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGGCTCGTAGAATTGGCG
ATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGGCAACCTAGAACAAAAGATAGATGAACTCAAAGATTCT
ACAAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCAAAACAAGTGCCTGCTGGTTTGTCAGCGAAATTGGACAATTA
CGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAGCAATTAATGAGAAAGCGACCGGCATGCTAACGC
AAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGTGCTCATTTGTCAGAGTAT
GATAAAATTGGATTCAACCAAAAGAATATGAAAGGTTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGT
AAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATG
TGGAACATGGAGTCAAAAATACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNIATTTTSIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSSIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGSNVATLINAHLNNGSGLVIAGNENGIKNPSFYLYKEDQLTGLKQALSQEEIQN
KVDFMEFLAKNNAKLDNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLLAKGLSPQEANKLIKDFLNSNKEMVGKVLNFNKAVAGAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NNNKNRMEAKAQANSQKDKIFALINQEASKEARAAAFDPSLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLAINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQVLAELKNLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NNTEPIYAQVNKKKTGQATSPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRIGNGLSKTEATTLTKNFSDIRKELNEK
LFGNSNNNNNGLKNNTEPIYAQVNKKKTGQATSPEESIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGF
SGAGRSASPEPIYATIDFDEANQAGFPLRRSAAVNDLSKVGLSREQELARRIGDLNQAVSEAKTGHFGNLEQKIDELKDS
TKKNALKLWVESAKQVPAGLSAKLDNYATNSHTRINSNVQSGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEY
DKIGFNQKNMKGYSDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKGGFQKS
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