Name : cagA
Accession : BAC10423.1
PAI name : cag PAI
PAI accession : AB090077
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 47 hits ( 46 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACCAGATCAAACACCAAATCAAACAGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATGAAAAATT
CATGGGTGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACACTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGAATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGGGTCATAGTAACATAGAACCTGAAAAGGTT
TCATTATTGTATGGGGATAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATCAATGCGCATCTTCATAACGGCAGTGGGTTAGTCATAGCGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTCTATCTCTACAAAGCAGACCAACTCACAGGTTTGAAACAAGCAATGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTCGCGCAAAACAACGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AGCTGAGATTGGAAATTTCCAAAAAGACCGTAAAGCTTATTTAGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTTGA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAATTGGTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGA
GGCTAGTAAGGAAGCAAGAGCAGCCGCTTTCGATCCGAATCTTAAAGGTATCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACAACACAGAGCCCATTTACGCTCAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAACCCTGAAGAGCCCATTTACGC
TCAAGTTGCTAAAGAAGCCACAACGCTCACCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAA
ATTCCAATAACAATAATAATGGACTCAAAAACAACACAGAGCCCATTTACGCTCAAGTTAATAAAAAGAAAACAGGACAA
GTAGCTAACCCTGAAGAGCCCATTTACGCTCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTAC
ATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGTGGTTTCAGTGGAGCAG
GGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGA
AGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCA
GGCGGTATCAGAAGCTAAAACAGGTCATTTTGGCAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGA
ATGCTTTGAAGCTATGGGTTGAAAGTGCGAAACAAGTGCCTACTAGTTTGCAAGCGAAATTGGACAATTACGCTACTAAC
AGCCACACACGCATTAATAGCAATGTCCAAACTGGAACAATCAATGAAAAAGCGACCGGTATGCTAACGCAAAAAAACCC
TGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGTGTTCCTTTGTCAGAGTATGATAAAATTG
GATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATT
AAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGCGGAACATGG
AGTCAAAAATACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKNPNYKFNQLLIHNNALSSVLMGGHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLHNGSGLVIAGNEDGIKNPSFYLYKADQLTGLKQAMSQEEIQN
KVDFMEFLAQNNAKLDNLSEKEKEKFQAEIGNFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVDYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLLAKGLSPQEANKLIKDFLNSNKELVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NNTEPIYAQVNKKKTGQVANPEEPIYAQVAKEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNNTEPIYAQVNKKKTGQ
VANPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFDEANQAGFPLRR
SAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVPTSLQAKLDNYATN
SHTRINSNVQTGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDI
KSSFVQFLTNTFSTGSYSLMKANAEHGVKNTTKGGFQKS
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