Name : cagA
Accession : BAC10422.1
PAI name : cag PAI
PAI accession : AB090076
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 46 hits ( 45 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Azuma,T. and Hatakeyama,M., "Virulence of Helicobacter pylori CagA depends on its potential to bind SHP-2 phosphatase", Unpublished.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAAACAACAACACTGGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAAAAAATCTCGCAACTAAGGAAAGAATACGCTAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAATATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTGAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATGTAGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTGTCTTCTGTGCTAATGGGGGGTCATAGTAACATAGAACCTGAAAAAGTT
TCATTATTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGG
CAACAATGTGGCCACACTCATCAATGCGCATCTTAATAACGGCAGCGGGTTAATCATAGTGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTCTATCTCTACAAAACAGACCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCAAAAAACAACGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAAATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGAGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTTGA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTTGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAAATGGTTGGAAAAGTTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCGTTGATCAATACAGA
GGCTAGTAAGGAAGCAAGAGTGGCCGCTTTCGATCCGAATCTTAAAAGCACCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGTAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTGGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAGTTATTTGGAAATTCCAATAACAATAATAATGGGCTCAAA
AACAGCACAGAGCCCATTTACGCTCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGC
AATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAGTTGGAAAAAATTCTGATCTACAAAAATCCGTTAAAAATG
GTGTAAATGGAACCCTGGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTTCGGACATCAGG
AAAGAATTGAACGAGAAGTTATTTGGAAATTCCAATAACAATAATAATGGGCTCAAAAACAGCACAGAGCCCATTTACGC
TAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCTAAAAAGGTGAGTG
CAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAGCAGGT
AAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGATGAGGC
AAATCAAGCAGGCTTCCCTTTGAGAAGAAGTACTGGAGTTAATGACCTCAGTAAAGTAGGGCTTTCAAGGAAACAAGAAT
TGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTTATTTTGACAACCTAGAACAAAAGATA
GATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGTTATTTGTTGAAAGTGCGAAACAAGTGCCTACTGGTTTGCA
AGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAGCAATCAATGAAAAGG
CGACCGGCATGCTGACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGC
ACTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCAC
CAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGATCTTACA
GCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAGTACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTLDQTPNQTDFVPQRFINNLQVAFLKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLRKEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSEINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKDQQGNNVATLINAHLNNGSGLIIVGNEDGIKNPSFYLYKTDQLTGLKQALSQEEIQN
KVDFMEFLAKNNAKLDNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNEEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVDYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLWAKGLSPQEANKLIKDFLNSNKEMVGKVLNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINTEASKEARVAAFDPNLKSTRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NSTEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASVGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIR
KELNEKLFGNSNNNNNGLKNSTEPIYAKVNKKKTGQVASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAG
KGVGGFSGAGRSASPEPIYATIDFDEANQAGFPLRRSTGVNDLSKVGLSRKQELTRRIGDLNQAVSEAKTGYFDNLEQKI
DELKDSTKKNALKLFVESAKQVPTGLQAKLDNYATNSHTRINSNVQSGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGS
THLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKSTTKGGFQKS
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