Name : cagA
Accession : BAC10420.1
PAI name : cag PAI
PAI accession : AB090074
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : CagA
Function : -
Note : -
Homologs in the searched genomes : 48 hits ( 47 protein-level, 1 DNA-level )
Publication :
-Higashi,H., Tsutsumi,R., Fujita,A., Yamazaki,S., Asaka,M., Azuma,T. and Hatakeyama,M., "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14428-14433 (2002) PUBMED 12391297.
-Yamakawa,A., Yamazaki,S. and Azuma,T., "Direct Submission", Submitted (19-AUG-2002) Takeshi Azuma, Fukui Medical University, Second Department of Internal Medicine; Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan (E-mail:azuma@fmsrsa.fukui-med.ac.jp, Tel:81-776-61-8351, Fax:81-776-61-8110).
| DNA sequence : | |
ATGACTAACGAAACTATTGATCAGACAACAACACCAGATCAAACAGATTTTGTTCCGCAACGATTTATCAATAATCTTCA
AGTGGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGG
ATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAATCCTACCAAAAAG
AATCAGTATTTTTCAGACTTTATCAATAAGAGTAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGT
AGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCGTCTAAAA
TCAACACCCAACAAATCCAAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGTTT
TTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTT
TGATGAATTTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTAT
CATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAAT
TTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGGTAATTTTTTTAA
ATTCACTCTTGGTGATGTGGAAATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGTTCAATCAGTTAT
TGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGAGTCATAGCAACATAGAACCTGAAAAAGTTTCATTATTGTAT
GGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAACAATGTGGC
CACACTCATTAATGCGCATCTTAATAACGGCAGCGGGTTAATCATAGTGGGTAATGAAAATGGGATTAAAAACCCTAGCT
TCTATCTCTACAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTC
ATGGAATTTCTTGTGCAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAACTGAGATTGA
AGATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAA
AACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAAAAACAAGATAAA
GCTTTAGATGGGGAGGTAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCATGATGTTTGTTGATTATTCCAATTT
CAAATACACCAACGCTTCCAAGAGTCCTAATAAGGGCGTGGGCGCTACGAATGGCGTTTCCCATTTGGAAGCAAATTTTA
GCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAA
TTGTGGGCTAAAGGATTGTCCCGACAAGAATCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAAATGGTTGG
AAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAATACAGGCAATTATGATGGAGTGAAAAAAGCTCAGAAAG
ATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTGGCGAAAAAATTGGAGAGCAGAAATGACAACAAA
AATAGAATGGAAGTAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGAGGCTAGTAAGGA
AGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAAATATCAACAAGA
ATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATAGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTA
AAAGCCCTTAAAGACTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTT
GAATGATTTCAAAAATAGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGG
ATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATTAGAGACTAAATCAACAGGCAAT
TTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATC
CGTTAAAAATGGTGTAAATGGAACCCTGGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTT
CGGACATCAGGAAAGAATTGAACGAGAAGTTATTTGGAAATTCCAATAACAATAATAATGGGCTCAAAAACAGCACAGAG
CCCATTTACGCTAAAGTTAATAAAAAGAAAGCAGGACAAGCAACTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCTAA
AAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTG
CATCAGCAGGTAAAGGAGTGGGCGCTTTCAGTGGAGCAAGGCAATCAGCTAGCCCTGAACCTATTTACGCTACAATTGAT
TTTGATGAGGCAAATCAAGCAGGCTTCCCTCTTAGGAGATACGCTCCAGTTGATGATCTCAGTAAAGTAGGGCTTTCAAG
GGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATTTTGACAACCTAG
AACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCGAAACAAGTGCCT
ACTAGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAGCAAT
CAATGAAAAGGCGACCGGCATGCTGACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCACATA
ATGTGGGAAGCGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTC
AAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTAC
AGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAGTACTACAAAAGGTGGTTTCCAAAAATCTTAA
|
| Protein sequence : | |
MTNETIDQTTTPDQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKNPTKK
NQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIQNFMENIIQPPISDDKEKAEF
LRSAKQSFAGIIIGNQIRSDQKFMGVFDEFLKERQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQN
LATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSNIEPEKVSLLY
GDNGGPEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLIIVGNENGIKNPSFYLYKEDQLTGLKQALSQEEIQNKVDF
MEFLVQNNAKLDNLSEKEKEKFQTEIEDFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGKKQDK
ALDGEVKTTLQGSLKYDGMMFVDYSNFKYTNASKSPNKGVGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSRQESNKLIKDFLNSNKEMVGKVSNFNKAVAEAKNTGNYDGVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNK
NRMEVKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNSKNKDFSKAEETL
KALKDSVKDLGINPEWISKIENLNAALNDFKNSKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVLETKSTGN
FSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNSTE
PIYAKVNKKKAGQATSPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGAFSGARQSASPEPIYATID
FDEANQAGFPLRRYAPVDDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFDNLEQKIDELKDSTKKNALKLWVESAKQVP
TSLQAKLDNYATNSHTRINSNVQSGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKSTTKGGFQKS
|
|
