Name : aphA1b
Accession : AFV53106.1
PAI name : AbGRI2-1
PAI accession : JX869489
Strain : Acinetobacter baumannii 1656-2
Virulence or Resistance: Resistance
Product : aminoglycoside (3') phosphotransferase AphA1 or APH (3')-Ia
Function : -
Note : confers resistance to kanamycin and neomycin
Homologs in the searched genomes : 20 hits ( 20 protein-level )
Publication :
-Nigro,S.J., Farrugia,D.N., Paulsen,I.T. and Hall,R.M., "A novel family of genomic resistance islands, AbGRI2, contributing to aminoglycoside resistance in Acinetobacter baumannii isolates belonging to global clone 2", J. Antimicrob. Chemother. 68 (3), 554-557 (2013) PUBMED 23169892.
-Nigro,S.J., Farugia,D.N., Paulsen,I.T. and Hall,R.M., "Direct Submission", Submitted (24-SEP-2012) School of Molecular Bioscience, University of Sydney, Molecular Bioscience Bldg G08, Sydney, NSW 2006, Australia.
| DNA sequence : | |
ATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACCTGGATGCTGATTTATATGGGTATAG
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCAATGCGCCAGAGTTGTTTC
TGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGACTAAACTGGCTGACGGCATTTATGCCT
CTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATT
CCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGA
TTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTG
GTTGATGCTAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAAGCTTTTGCC
ATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTT
GTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCT
CCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCT
CGATGAGTTTTTCTGA
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| Protein sequence : | |
MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMP
LPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGL
VDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFS
PSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF
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