PAI Gene Information


Name : aadA1
Accession : ACV89835.1
PAI name : AbaR7
PAI accession : GQ406246
Strain : Acinetobacter baumannii 1656-2
Virulence or Resistance: Resistance
Product : AadA1 aminoglycoside (3')(9) adenylyltransferase
Function : -
Note : confers resistance to spectinomycin and streptomycin
Homologs in the searched genomes :   130 hits    ( 130 protein-level )  
Publication :
    -Hamidian,M. and Hall,R.M., "Resistance to cephalosporins in Acinetobacter baumannii due to replacement of the chromosomal ampC gene by an IS activated ampC gene", Unpublished.

    -Hamidian,M., Post,V. and Hall,R.M., "Direct Submission", Submitted (08-FEB-2012) School of Molecular and Microbial Biosciences, The University of Sydney, Biochemistry Building G08, Sydney, NSW 2061, Australia REMARK Sequence update by submitter.

    -Post,V. and Hall,R.M., "Direct Submission", Submitted (23-JUL-2009) School of Molecular and Microbial Biosciences, The University of Sydney, Biochemistry Building G08, Sydney, NSW 2061, Australia.

    -Post,V., White,P.A. and Hall,R.M., "Evolution of AbaR-type genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii", J. Antimicrob. Chemother. 65 (6), 1162-1170 (2010) PUBMED 20375036.


DNA sequence : 
ATGAGGGAAGCGGTGATCGCCGAAGTATCGACTCAACTATCAGAGGTAGTTGGCGTCATCGAGCGCCATCTCGAACCGAC
GTTGCTGGCCGTACATTTGTACGGCTCCGCAGTGGATGGCGGCCTGAAGCCACACAGTGATATTGATTTGCTGGTTACGG
TGACCGTAAGGCTTGATGAAACAACGCGGCGAGCTTTGATCAACGACCTTTTGGAAACTTCGGCTTCCCCTGGAGAGAGC
GAGATTCTCCGCGCTGTAGAAGTCACCATTGTTGTGCACGACGACATCATTCCGTGGCGTTATCCAGCTAAGCGCGAACT
GCAATTTGGAGAATGGCAGCGCAATGACATTCTTGCAGGTATCTTCGAGCCAGCCACGATCGACATTGATCTGGCTATCT
TGCTGACAAAAGCAAGAGAACATAGCGTTGCCTTGGTAGGTCCAGCGGCGGAGGAACTCTTTGATCCGGTTCCTGAACAG
GATCTATTTGAGGCGCTAAATGAAACCTTAACGCTATGGAACTCGCCGCCCGACTGGGCTGGCGATGAGCGAAATGTAGT
GCTTACGTTGTCCCGCATTTGGTACAGCGCAGTAACCGGCAAAATCGCGCCGAAGGATGTCGCTGCCGACTGGGCAATGG
AGCGCCTGCCGGCCCAGTATCAGCCCGTCATACTTGAAGCTAGACAGGCTTATCTTGGACAAGAAGAAGATCGCTTGGCC
TCGCGCGCAGATCAGTTGGAAGAATTTGTCCACTACGTGAAAGGCGAGATCACCAAGGTAGTCGGCAAATAA

Protein sequence : 
MREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDETTRRALINDLLETSASPGES
EILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQ
DLFEALNETLTLWNSPPDWAGDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQPVILEARQAYLGQEEDRLA
SRADQLEEFVHYVKGEITKVVGK