PAI Gene Information


Name : aacC1/aacCA1
Accession : ACV89833.1
PAI name : AbaR7
PAI accession : GQ406246
Strain : Acinetobacter baumannii 1656-2
Virulence or Resistance: Resistance
Product : type A aminoglycoside-(3)-acetyltransferase AacC-A1 or AacC1 or AAC-(3)-Ia
Function : -
Note : confers resistance to gentamicin; contains a 23 aa N-terminal extension
Homologs in the searched genomes :   27 hits    ( 27 protein-level )  
Publication :
    -Hamidian,M. and Hall,R.M., "Resistance to cephalosporins in Acinetobacter baumannii due to replacement of the chromosomal ampC gene by an IS activated ampC gene", Unpublished.

    -Hamidian,M., Post,V. and Hall,R.M., "Direct Submission", Submitted (08-FEB-2012) School of Molecular and Microbial Biosciences, The University of Sydney, Biochemistry Building G08, Sydney, NSW 2061, Australia REMARK Sequence update by submitter.

    -Post,V. and Hall,R.M., "Direct Submission", Submitted (23-JUL-2009) School of Molecular and Microbial Biosciences, The University of Sydney, Biochemistry Building G08, Sydney, NSW 2061, Australia.

    -Post,V., White,P.A. and Hall,R.M., "Evolution of AbaR-type genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii", J. Antimicrob. Chemother. 65 (6), 1162-1170 (2010) PUBMED 20375036.


DNA sequence :
ATGTTACGCAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGTGGCTCAAGTATGGGCATCAT
TCGCACATGTAGGCTCGGCCCTGACCAAGTCAAATCCATGAGGGCTGCTCTTGATCTTTTCGGTCGTGAGTTCGGAGACG
TAGCCACCTACTCCCAACATCAGCCGGACTCCGATTACCTCGGGAACTTGCTCCGTAGTAAGACATTCATCGCGCTTGCT
GCCTTCGACCAAGAAGCGGTTGTTGGCGCTCTCGCGGCTTACGTTCTGCCAAAGTTTGAGCAGGCGCGTAGTGAGATCTA
TATCTATGATCTCGCAGTCTCCGGCGAGCACCGGAGGCAAGGCATTGCCACCGCGCTCATCAATCTCCTCAAGCATGAGG
CCAACGCGCTTGGTGCTTATGTGATCTACGTGCAAGCAGATTACGGTGACGATCCCGCAGTGGCTCTCTATACAAAGTTG
GGCATACGGGAAGAAGTGATGCACTTTGATATCGACCCAAGTACCGCCACCTAA

Protein sequence :
MLRSSNDVTQQGSRPKTKLGGSSMGIIRTCRLGPDQVKSMRAALDLFGREFGDVATYSQHQPDSDYLGNLLRSKTFIALA
AFDQEAVVGALAAYVLPKFEQARSEIYIYDLAVSGEHRRQGIATALINLLKHEANALGAYVIYVQADYGDDPAVALYTKL
GIREEVMHFDIDPSTAT