PAI Gene Information


Name : pdpA
Accession : AAP58968.1
PAI name : FPI
PAI accession : AY293579
Strain : Francisella novicida 3523
Virulence or Resistance: Virulence
Product : PdpA
Function : -
Note : transposon insertions in pdpA abrogate the ability of Francisella tularensis subsp. novicida to grow in mouse macrophages and to cause disease in mice
Homologs in the searched genomes :   30 hits    ( 30 protein-level )  
Publication :
    -Gray,C.G., Cowley,S.C., Cheung,K.K. and Nano,F.E., "The identification of five genetic loci of Francisella novicida associated with intracellular growth", FEMS Microbiol. Lett. 215 (1), 53-56 (2002) PUBMED 12393200.

    -Gray,C.J., Cowley,S.C. and Nano,F.E., "Direct Submission", Submitted (24-MAY-2001) Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Victoria, BC V8W 3P6, Canada.

    -Nano,F.E., Zhang,N., Cheung,K.K.M., Roberts,M.J., Ludu,J.S., Letendre,G.W., Meierovics,A.I., Cowley,S.C. and Elkins,K.L., "Direct Submission", Submitted (08-MAY-2003) Biochemistry and Microbiology, University of Victoria, Petch Building 207, Ring Road, Victoria, B.C. V8P 5C2, Canada.

    -Nano,F.E., Zhang,N., Cowley,S.C., Klose,K.E., Cheung,K.K., Roberts,M.J., Ludu,J.S., Letendre,G.W., Meierovics,A.I., Stephens,G. and Elkins,K.L., "A Francisella tularensis pathogenicity island required for intramacrophage growth", J. Bacteriol. 186 (19), 6430-6436 (2004) PUBMED 15375123.


DNA sequence : 
ATGATAGCAGTAAAAGATATAACTGATCTAAATATACAAGACATAATTAGTCAGTTAACTTCTGAAGTTATAAATGGCGA
CACAACCCCTTCTTCCGCCAAGTTTGCTTGTGAAATTAATAGCTATATTATTAATTACAACCTATCAAACATTAATCTTA
TTAATACTCAACTAAAAAATACAAAGATACTTTATAGAAAAGGCTTGATATCTAAGCTTGATTACGAAAAATATAAAAGA
TATTGCATAATATCTAGATTTAAAAATAACATAGATGAATTTATCTTATATTTTTCGACAAACTATAAAGACTCTCAAAG
CTTAAAAATCGCAATTAAAGAATTACAAAACTCATGCTCATCAAGTTTAATTCTTGAGCTCCCTCATGATTACATAAGAA
AAATTGATGTCTTACTAACTAGTATAGATAGTGCAATACAAAGATCAAGCGATCTCAACAAAACAATTATAAAACAGTTA
AATAAGCTTAGAAGCAGCCTTTCACGATATATTGGGTATAATAATGTACTGCAAAAACAAGAAATTACTATAAATATAAA
GCCTATTAATAAAAATTTTGAACTTGAGGATATAAGTTTTGTATCAACTAGAAATAAGCAATATTTTAAGCATAACTCTC
TTACACTTAAAAACCCTCATATTGAAAAATTAGAAGTATGTGAAAATATCTACGGCATAAACGGCTGGTTAACTTTTGAT
TTAGCATATATCAATAATCACAAAGACTTTAACTTTCTATTAAGCCCAAATCAACCCATATTGCTTGATATTCAAATTAA
TGATAGCTTCAACTTTTACAAAAAAGAATCTAAAAAAGATCATCATAAGAGAACAACCCGTTTTATAGCCATTGGCTTTA
ATTCAAACAGTATAGATATTCATGAGAACTTTGAATATAGCATATATTCTTATACCAAAAATGTTTCTTCAGGAGTAAAA
AAATTTAAAATACAATTCCATGACCCACTAAAAGCACTTTGGACTAAGCACAAACCATCCTATATAGCCTTGAACAAAAG
CTTAGATGATATCTTTAAAGATAATTTTTTCTTTGATAGTTTATTTTCTTTAGATACCAACAAAAGTAATAATCTAAAAA
TACGTATACCACAAGCATTTATTTCTACAGTTAATCGAAATTTTTATGATTTCTTTATTCAACAACTTGAGCAAAATAAA
TGCTATTTAAAATATTTCTGTGATAAGAAGAGTGGCAAAGTAAGCTATCATGTTGTAGATCAAGTAGATAATGACTTACA
AAGGAATATCGTAAATTCAGATGAAGATTTAAAAGACAAACTATCTCCTTATGATATAAGCTGCTTCAAAAAACAAATTC
TAATCTCAAATAAGTCAAACTTTTATGTTAAGGAAAAAAATATATGTCCTGATGTGACTTTAAACACTCAAAGAAAGGAA
GACCGAAAGATTTCAGATACCTTAGTAAAGCCATTCTCATCCATACTCAAGGATAACTTACAATCTGTAGAGTATATACA
AAGTAATAATGATGATAAACAAGAAATTATTACTACAGGATTTGAGATATTACTGACATCAAGAAATACTCTGCCCTTCT
TAGATACTGAAATTACTCTTTCTAAACTAGACAATGATCAAAACTATCTTTTAGGCGCAACAGATATAAAAAGCTTATAT
ATAAGTCAAAGAAAGCTATTATTTAAAAGAAGTAAATACTGCTCTAAACAACTATATGAAAACTTACATAATTTTCACTA
TAAAAGTGATTCTGAATCAGACGTATATGAAAAAATTGCTTTTACTAAATACCCTAGTCTGACACATGACAACTCAATAA
CTTATAAAATTAAGGATTATAGTAATCTAACTCCTGAATATCCTAAGTACAAAAGTTTTAGTAACTTTTATATTAATGGT
AGAATAACGATTGGAGAAAATGTTAATAATGACTCCAAAAAAGCTTATAAATTCTTTAAAAATCATAAGCCAGAAGAAAG
CTCAATCGCAGAATTTCAAGAAAATGGTGAAAAAGGTACTTCAGCTATACTAAATAGTAAGGCTGATATCTTATACGCAA
TAGAAATTGCCAAGGAAATGTTGTCTGATAAATCATCAGATAAGCCAATCATATACTTACCTCTAAAAGTAAACATAAAT
TCTGCTAATAATCAATTTATACCATTGAGAAATGACGATATTATCTTAATTGAAATACAGTCTTTTACTAAAGGTGAAAT
TATTGAGTTAATTTCGAACTCTGCCATATCAACAAAGAAAGCTCAGCAGCAACTACTACAACGACAACTTCTTGGATCTA
AAGAAAACTGTGAAATGGCATATACCCAAACAAGTGATAGCGAGACATTCTCACTAACTCAAGTAAATGAAGATTGTGAG
AATTCTTTTTTGATAAATGATAAAAAAGGTATTTTTCTAAGATATAAATCAAAAGGAAATTAA

Protein sequence : 
MIAVKDITDLNIQDIISQLTSEVINGDTTPSSAKFACEINSYIINYNLSNINLINTQLKNTKILYRKGLISKLDYEKYKR
YCIISRFKNNIDEFILYFSTNYKDSQSLKIAIKELQNSCSSSLILELPHDYIRKIDVLLTSIDSAIQRSSDLNKTIIKQL
NKLRSSLSRYIGYNNVLQKQEITINIKPINKNFELEDISFVSTRNKQYFKHNSLTLKNPHIEKLEVCENIYGINGWLTFD
LAYINNHKDFNFLLSPNQPILLDIQINDSFNFYKKESKKDHHKRTTRFIAIGFNSNSIDIHENFEYSIYSYTKNVSSGVK
KFKIQFHDPLKALWTKHKPSYIALNKSLDDIFKDNFFFDSLFSLDTNKSNNLKIRIPQAFISTVNRNFYDFFIQQLEQNK
CYLKYFCDKKSGKVSYHVVDQVDNDLQRNIVNSDEDLKDKLSPYDISCFKKQILISNKSNFYVKEKNICPDVTLNTQRKE
DRKISDTLVKPFSSILKDNLQSVEYIQSNNDDKQEIITTGFEILLTSRNTLPFLDTEITLSKLDNDQNYLLGATDIKSLY
ISQRKLLFKRSKYCSKQLYENLHNFHYKSDSESDVYEKIAFTKYPSLTHDNSITYKIKDYSNLTPEYPKYKSFSNFYING
RITIGENVNNDSKKAYKFFKNHKPEESSIAEFQENGEKGTSAILNSKADILYAIEIAKEMLSDKSSDKPIIYLPLKVNIN
SANNQFIPLRNDDIILIEIQSFTKGEIIELISNSAISTKKAQQQLLQRQLLGSKENCEMAYTQTSDSETFSLTQVNEDCE
NSFLINDKKGIFLRYKSKGN