PAI Gene Information


Name : int
Accession : AAK00456.1
PAI name : SHI-1
PAI accession : AF200692
Strain : Shigella flexneri 2002017
Virulence or Resistance: Not determined
Product : Int
Function : -
Note : -
Homologs in the searched genomes :   437 hits    ( 436 protein-level,   1 DNA-level )  
Publication :
    -Al-Hasani,K., Henderson,I.R., Sakellaris,H., Rajakumar,K., Grant,T., Nataro,J.P., Robins-Browne,R. and Adler,B., "The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation", Infect. Immun. 68 (5), 2457-2463 (2000) PUBMED 10768931.

    -Al-Hasani,K., Rajakumar,K. and Adler,B., "Direct Submission", Submitted (01-NOV-1999) Microbiology, Monash University, Wellington Road, Clayton, Vic 3800, Australia.

    -Al-Hasani,K., Rajakumar,K., Adler,B. and Sakellaris,H., "Direct Submission", Submitted (16-JAN-2001) Microbiology, Monash University, Wellington Road, Clayton, Vic 3800, Australia REMARK Sequence update by submitter.

    -Al-Hasani,K., Rajakumar,K., Bulach,D., Robins-Browne,R., Adler,B. and Sakellaris,H., "Genetic organization of the she pathogenicity island in Shigella flexneri 2a", Microb. Pathog. 30 (1), 1-8 (2001) PUBMED 11162180.


DNA sequence : 
ATGTTCCTGCTGGTTCATCCTAATGGTTCCCGTTACTGGCGTCTCCGTTATCGTATTCTGGGTAAGGAGAAGACTCTGGC
ACTTGGTGTGTATCCAGAAGTTTCTCTCTCCGAAGCTCGTACAAAACGGGATGAGGCCCGAAAACTGATTTCAGAGGGGA
TTGACCCTTGCGAACAGAAAAGAGTTAAAAAAGTTGTCCCTGATTTACAGCTCTCTTTTGAACATATTGCACGACGCTGG
CATGCCAGTAATAAACAATGGGCACAATCACACAGCGATAAAGTACTCAAAAGCCTCGAGACACACGTTTTCCCCTTTAT
CGGCAACCGGGATATCACAACACTCAATACCCCGGACCTGCTTATCCCTGTTCGTGCTGCAGAAGCAAAACAAATTTATG
AAATCGCCAGTCGTCTGCAGCAAAGAATATCTGCTGTAATGCGTTACGCCGTACAGTCTGGCATCATCAGATATAACCCG
GCTCTGGATATGGCTGGTGCATTGACCACGGTAAAACGCCAGCATCGCCCTGCTCTGGAGCTTTCACGCCTGCCTGAACT
TCTGTCGCGTATTGACGGTTATAAAGGCCAGCCTGTCACCCGACTGGCAGTTATGCTGAATTTACTGGTTTTTATTCGTT
CCAGTGAACTCAGATATGCCCGCTGGTCGGAAATTGATATTGACAATTCCATGTGGACTATTCCAGCCGAACGCGAACCT
CTGCCAGGCGTAAAATTCTCACACCGGGGATCCAAGATGCGAACACCACATCTTGTGCCACTCAGCAAACAGGTTGTAGC
CATACTGGCAGAACTTCAGACATGGGCTGGTGAAAATGGTCTGATCTTTACGGGTGCACATGACCCGCGTAAACCAATCA
GTGAAAATACTGTAAATAAAGCCCTGAGGGTGATGGGGTATGACACAACCCAGGAAGTCTGTGGCCATGGATTCCGGGCG
ATGGCGTGCAGTGCATTGATTGAATCAGGTTTGTGGTCCCGCGATGCTGTGGAACGTCAGATGAGCCATCAGGAGCGTAA
TGGTGTACGTGCTGCGTATATCCATAAAGCAGAACATCTGGAAGAACGGCGACTGATGTTGCAATGGTGGGCCGATTTTC
TAGATGCGAACCGGGAGAAGGGTATCAGCCCGTTTGAATATGCAAAGATTAACAATCCATTAAAATAG

Protein sequence : 
MFLLVHPNGSRYWRLRYRILGKEKTLALGVYPEVSLSEARTKRDEARKLISEGIDPCEQKRVKKVVPDLQLSFEHIARRW
HASNKQWAQSHSDKVLKSLETHVFPFIGNRDITTLNTPDLLIPVRAAEAKQIYEIASRLQQRISAVMRYAVQSGIIRYNP
ALDMAGALTTVKRQHRPALELSRLPELLSRIDGYKGQPVTRLAVMLNLLVFIRSSELRYARWSEIDIDNSMWTIPAEREP
LPGVKFSHRGSKMRTPHLVPLSKQVVAILAELQTWAGENGLIFTGAHDPRKPISENTVNKALRVMGYDTTQEVCGHGFRA
MACSALIESGLWSRDAVERQMSHQERNGVRAAYIHKAEHLEERRLMLQWWADFLDANREKGISPFEYAKINNPLK