PAI Gene Information


Name : cag-alfa
Accession : AAF80196.1
PAI name : cag PAI
PAI accession : AF282852
Strain : Helicobacter pylori 2017
Virulence or Resistance: Virulence
Product : Cag-alfa
Function : -
Note : similar to VirB11; HP525; JHP474, ORF11
Homologs in the searched genomes :   53 hits    ( 53 protein-level )  
Publication :
    -Censini,S., Lange,C., Xiang,Z., Crabtree,J.E., Ghiara,P., Borodovsky,M., Rappuoli,R. and Covacci,A., "cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors", Proc. Natl. Acad. Sci. U.S.A. 93 (25), 14648-14653 (1996) PUBMED 8962108.

    -Censini,S., Rappuoli,R. and Covacci,A., "Direct Submission", Submitted (17-MAR-2000) Molecular Biology, Chiron-Biocine, Via Fiorentina 1, Siena, SI 53100, Italy REMARK Sequence update by submitter.

    -Censini,S., Rappuoli,R., Lange,C. and Covacci,A., "Direct Submission", Submitted (06-JUN-1996) Molecular Biology, Chiron-Biocine, Via Fiorentina 1, Siena, SI 53100, Italy.

    -Covacci,A. and Rappuoli,R., "Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell", J. Exp. Med. 191 (4), 587-592 (2000) PUBMED 10684850.


DNA sequence : 
ATGACTGAAGACAGATTGAGTGCAGAAGATAAAAAATTTCTAGAAGTAGAAAGAGCTTTAAAAGAAGCAGCATTAAATCC
TCTAAGGCATGCTACTGAAGAACTTTTTGGCGATTTTTTAAAAATGGAAAATATCACTGAGATTTGTTACAATGGGAACA
AGGTTGTATGGGTTTTAAAAAATAATGGCGAATGGCAACCATTTGATGTGAGAGACAGGAAAGCCTTTAGCCTGTCTCGT
TTAATGCATTTTGCTCGGTGCTGTGCAAGTTTTAAGAAAAAAACAATAGACAACTATGAAAATCCTATTTTGAGCAGCAA
TTTAGCGAATGGTGAAAGGGTGCAGATTGTCCTTTCCCCTGTTACAGTTAATGATGAAACCATTTCCATATCCATAAGGA
TACCTAGCAAAACAACCTATCCTCATAGCTTCTTTGAAGAGCAAGGTTTTTATAATCTACTAGACAACAAAGAACAAGCG
ATCAGTGCGATTAAAGATGGTATTGCTATTGGTAAAAATGTGATTGTTTGTGGTGGCACAGGAAGCGGTAAAACGACTTA
TATCAAAAGCATCATGGAGTTTATCCCTAAAGAAGAAAGGATCATATCCATTGAAGACACCGAAGAGATTGTATTCAAAC
ACCACAAAAACTACACACAGCTTTTTTTTGGCGGGAATATCACCTCTGCTGATTGCTTAAAGTCATGTCTGAGAATGCGG
CCTGATAGAATCATTTTAGGGGAACTCAGAAGCAGTGAGGCATACGATTTTTATAATGTGCTTTGTAGCGGTCATAAAGG
CACGCTAACCACTCTGCATGCAGGGAGCAGTGAAGAAGCGTTTATTCGTTTAGCCAACATGAGTTCATCTAATAGCGCAG
CAAGGAATATCAAGTTTGAAAGTCTCATTGAGGGCTTTAAAGATTTGATTGATATGATTGTCCATATCAACCACCACAAA
CAGTGTGATGAATTTTATATCAAACATAGGTAG

Protein sequence : 
MTEDRLSAEDKKFLEVERALKEAALNPLRHATEELFGDFLKMENITEICYNGNKVVWVLKNNGEWQPFDVRDRKAFSLSR
LMHFARCCASFKKKTIDNYENPILSSNLANGERVQIVLSPVTVNDETISISIRIPSKTTYPHSFFEEQGFYNLLDNKEQA
ISAIKDGIAIGKNVIVCGGTGSGKTTYIKSIMEFIPKEERIISIEDTEEIVFKHHKNYTQLFFGGNITSADCLKSCLRMR
PDRIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLANMSSSNSAARNIKFESLIEGFKDLIDMIVHINHHK
QCDEFYIKHR