Name : sigA
Accession : AAF67320.1
PAI name : SHI-1
PAI accession : AF200692
Strain : Shigella flexneri 2002017
Virulence or Resistance: Virulence
Product : exported serine protease SigA
Function : -
Note : cytopathic protein
Homologs in the searched genomes : 30 hits ( 30 protein-level )
Publication :
-Al-Hasani,K., Henderson,I.R., Sakellaris,H., Rajakumar,K., Grant,T., Nataro,J.P., Robins-Browne,R. and Adler,B., "The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation", Infect. Immun. 68 (5), 2457-2463 (2000) PUBMED 10768931.
-Al-Hasani,K., Rajakumar,K. and Adler,B., "Direct Submission", Submitted (01-NOV-1999) Microbiology, Monash University, Wellington Road, Clayton, Vic 3800, Australia.
-Al-Hasani,K., Rajakumar,K., Adler,B. and Sakellaris,H., "Direct Submission", Submitted (16-JAN-2001) Microbiology, Monash University, Wellington Road, Clayton, Vic 3800, Australia REMARK Sequence update by submitter.
-Al-Hasani,K., Rajakumar,K., Bulach,D., Robins-Browne,R., Adler,B. and Sakellaris,H., "Genetic organization of the she pathogenicity island in Shigella flexneri 2a", Microb. Pathog. 30 (1), 1-8 (2001) PUBMED 11162180.
| DNA sequence : | |
ATGAATAAAATTTATTCACTGAAATATAGTCATATTACAGGTGGATTAGTTGCTGTTTCTGAACTGACCCGGAAAGTTAG
TGTCGGTACATCAAGAAAGAAAGTTATCCTCGGTATTATTTTATCCTCAATATATGGAAGTTATGGCGAAACAGCATTTG
CAGCAATGCTGGATATAAATAATATATGGACCCGCGATTATCTTGACCTTGCTCAAAACAGAGGAGAGTTCAGACCGGGT
GCAACAAATGTTCAATTAATGATGAAAGATGGAAAGATATTTCATTTTCCAGAACTACCTGTACCTGATTTTTCTGCTGT
TTCCAACAAAGGTGCAACAACATCAATTGGAGGTGCGTACAGTGTTACTGCGACTCATAACGGTACACAGCATCATGCAA
TAACAACACAGTCATGGGATCAGACAGCATATAAAGCAAGTAACAGAGTATCATCTGGCGACTTTTCGGTTCATCGTCTG
AATAAATTCGTCGTGGAAACAACAGGGGTTACGGAGAGTGCCGACTTCTCACTTTCTCCCGAAGATGCGATGAAAAGATA
TGGCGTAAACTACAACGGTAAGGAACAAATAATTGGCTTCAGAGCAGGTGCCGGAACAACCTCAACGATATTAAACGGCA
AACAATATCTGTTTGGACAAAACTATAATCCCGACTTGTTAAGCGCAAGTCTTTTTAATCTGGACTGGAAAAACAAGAGT
TACATTTATACCAACAGAACCCCTTTTAAAAACTCACCAATTTTTGGCGATAGTGGTTCTGGTTCTTATCTATATGATAA
AGAACAACAAAAATGGGTTTTCCATGGTGTTACCAGTACAGTTGGTTTTATCAGTAGTACCAATATAGCCTGGACAAACT
ACTCGTTATTTAATAATATTCTGGTAAACAATTTAAAAAAGAATTTCACAAACACTATGCAGCTGGATGGTAAAAAACAA
GAGTTATCATCGATTATAAAAGATAAGGACCTGTCTGTCTCAGGAGGAGGGGTATTAACGCTCAAGCAGGATACCGATCT
TGGCATTGGCGGGCTTATATTCGATAAGAACCAGACATATAAAGTGTACGGAAAAGATAAGTCTTATAAAGGTGCCGGGA
TAGATATTGATAATAATACCACCGTTGAATGGAATGTTAAGGGCGTTGCCGGAGATAATCTGCATAAAATAGGTAGTGGT
ACTCTGGATGTAAAAATAGCACAGGGAAATAACCTTAAAATAGGTAATGGGACTGTCATCCTTAGTGCTGAAAAAGCCTT
CAATAAAATTTACATGGCCGGAGGTAAAGGTACGGTAAAAATAAATGCCAAAGACGCTTTAAGCGAAAGCGGTAATGGCG
AAATCTATTTTACCAGAAATGGCGGAACACTGGATCTAAACGGCTATGACCAGTCATTTCAGAAAATCGCAGCAACAGAT
GCGGGAACAACCGTAACGAACTCAAACGTGAAGCAATCAACATTATCACTTACTAATACTGATGCATATATGTACCATGG
GAATGTATCAGGTAATATAAGCATAAATCATATTATCAATACTACCCAGCAACATAACAATAATGCCAATCTGATCTTTG
ATGGCTCAGTCGATATCAAAAACGATATCTCTGTCCGGAATGCACAGTTAACATTACAAGGACATGCGACAGAACATGCC
ATATTTAAAGAAGGCAATAACAACTGTCCAATTCCTTTTTTATGTCAAAAAGACTATTCTGCTGCCATAAAGGACCAGGA
AAGCACTGTAAATAAACGTTACAATACGGAATATAAGTCCAACAATCAGATAGCCTCTTTTTCCCAGCCCGACTGGGAAA
GTCGTAAATTTAATTTCCGGAAATTAAATTTAGAAAACGCAACCCTGAGTATAGGCCGGGATGCTAATGTAAAAGGACAC
ATAGAGGCTAAAAACTCTCAAATTGTTCTGGGAAATAAAACTGCATACATTGACATGTTCTCAGGAAGAAACATTACTGG
CGAAGGTTTTGGATTCAGACAACAGCTTCGCTCCGGGGATTCAGCAGGCGAAAGTAGTTTCAACGGCAGTCTGAGTGCTC
AAAACAGCAAAATAACTGTTGGTGATAAATCAACTGTTACTATGACTGGTGCATTATCCTTAATTAATACAGACCTGATT
ATCAACAAAGGAGCTACTGTTACCGCCCAGGGAAAAATGTATGTAGATAAAGCTATTGAACTGGCCGGAACCCTGACATT
AACAGGCACCCCTACAGAAAATAATAAATACAGCCCGGCAATCTATATGTCAGATGGATATAATATGACAGAAGATGGTG
CCACGTTAAAGGCTCAAAATTATGCCTGGGTCAATGGTAATATAAAATCAGACAAAAAAGCATCTATTCTGTTTGGTGTT
GACCAGTATAAAGAAGATAACCTGGACAAAACCACACACACACCGCTGGCTACAGGTTTGCTGGGTGGCTTTGATACTTC
TTATACCGGAGGTATTGATGCTCCTGCAGCCTCAGCCAGCATGTATAACACCTTATGGAGAGTAAACGGACAGTCAGCCC
TGCAATCATTAAAAACCCGCGACAGTCTTTTGTTGTTTAGTAACATAGAGAATTCGGGTTTCCATACTGTGACAGTAAAC
ACACTGGATGCCACTAATACTGCTGTGATTATGCGGGCTGATCTGAGCCAGTCTGTAAATCAATCGGATAAACTCATTGT
TAAAAATCAGTTAACCGGAAGCAATAACAGTCTGTCGGTCGATATACAGAAAGTGGGAAATAATAACTCAGGATTAAACG
TTGACCTGATAACAGCCCCAAAAGGAAGCAATAAAGAGATATTTAAAGCCAGTACTCAGGCCATAGGTTTCAGCAACATA
TCTCCTGTGATCAGCACGAAAGAGGATCAGGAACATACCACGTGGACCCTGACCGGATATAAGGTGGCTGAAAATACAGC
ATCTTCCGGTGCAGCAAAATCGTATATGTCCGGTAATTACAAAGCCTTCCTGACAGAAGTCAACAACCTGAATAAACGAA
TGGGGGATCTGCGTGACACCAATGGCGAGGCCGGTGCATGGGCCCGCATCATGAGCGGAGCAGGTTCAGCTTCTGGTGGA
TACAGTGACAACTACACCCATGTGCAGATTGGTGTGGATAAAAAACATGAGCTGGATGGACTTGACCTTTTCACTGGTCT
GACTATGACGTATACCGACAGTCATGCCAGCAGTAATGCATTCAGTGGCAAGACGAAGTCCGTCGGGGCAGGTCTGTATG
CTTCCGCTATATTTGACTCTGGTGCCTATATCGACCTGATTAGTAAGTATGTTCACCATGATAATGAGTACTCGGCGACC
TTTGCTGGACTCGGAACAAAAGACTACAGTTCTCATTCCTTGTATGTGGGTGCTGAAGCAGGCTACCGCTATCATGTAAC
AGAAGACTCCTGGATTGAGCCGCAGGCAGAACTGGTTTATGGGGCCGTATCAGGTAAACGGTTCGACTGGCAGGATCGCG
GAATGAGCGTGACCATGAAGGATAAGGACTTTAATCCGCTGATTGGGCGTACCGGTGTTGATGTGGGTAAATCCTTCTCC
GGTAAGGACTGGAAAGTCACAGCCCGCGCCGGCCTTGGCTACCAGTTTGACCTGTTTGCCAACGGTGAAACCGTACTGCG
TGATGCGTCCGGTGAGAAACGTATCAAAGGTGAAAAAGACGGTCGTATTCTCATGAATGTTGGTCTCAACGCCGAAATTC
GCGATAATCTTCGCTTCGGTCTTGAGTTTGAGAAATCGGCATTTGGTAAATACAACGTGGATAACGCGATCAACGCCAAC
TTCCGTTACTCTTTCTGA
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| Protein sequence : | |
MNKIYSLKYSHITGGLVAVSELTRKVSVGTSRKKVILGIILSSIYGSYGETAFAAMLDINNIWTRDYLDLAQNRGEFRPG
ATNVQLMMKDGKIFHFPELPVPDFSAVSNKGATTSIGGAYSVTATHNGTQHHAITTQSWDQTAYKASNRVSSGDFSVHRL
NKFVVETTGVTESADFSLSPEDAMKRYGVNYNGKEQIIGFRAGAGTTSTILNGKQYLFGQNYNPDLLSASLFNLDWKNKS
YIYTNRTPFKNSPIFGDSGSGSYLYDKEQQKWVFHGVTSTVGFISSTNIAWTNYSLFNNILVNNLKKNFTNTMQLDGKKQ
ELSSIIKDKDLSVSGGGVLTLKQDTDLGIGGLIFDKNQTYKVYGKDKSYKGAGIDIDNNTTVEWNVKGVAGDNLHKIGSG
TLDVKIAQGNNLKIGNGTVILSAEKAFNKIYMAGGKGTVKINAKDALSESGNGEIYFTRNGGTLDLNGYDQSFQKIAATD
AGTTVTNSNVKQSTLSLTNTDAYMYHGNVSGNISINHIINTTQQHNNNANLIFDGSVDIKNDISVRNAQLTLQGHATEHA
IFKEGNNNCPIPFLCQKDYSAAIKDQESTVNKRYNTEYKSNNQIASFSQPDWESRKFNFRKLNLENATLSIGRDANVKGH
IEAKNSQIVLGNKTAYIDMFSGRNITGEGFGFRQQLRSGDSAGESSFNGSLSAQNSKITVGDKSTVTMTGALSLINTDLI
INKGATVTAQGKMYVDKAIELAGTLTLTGTPTENNKYSPAIYMSDGYNMTEDGATLKAQNYAWVNGNIKSDKKASILFGV
DQYKEDNLDKTTHTPLATGLLGGFDTSYTGGIDAPAASASMYNTLWRVNGQSALQSLKTRDSLLLFSNIENSGFHTVTVN
TLDATNTAVIMRADLSQSVNQSDKLIVKNQLTGSNNSLSVDIQKVGNNNSGLNVDLITAPKGSNKEIFKASTQAIGFSNI
SPVISTKEDQEHTTWTLTGYKVAENTASSGAAKSYMSGNYKAFLTEVNNLNKRMGDLRDTNGEAGAWARIMSGAGSASGG
YSDNYTHVQIGVDKKHELDGLDLFTGLTMTYTDSHASSNAFSGKTKSVGAGLYASAIFDSGAYIDLISKYVHHDNEYSAT
FAGLGTKDYSSHSLYVGAEAGYRYHVTEDSWIEPQAELVYGAVSGKRFDWQDRGMSVTMKDKDFNPLIGRTGVDVGKSFS
GKDWKVTARAGLGYQFDLFANGETVLRDASGEKRIKGEKDGRILMNVGLNAEIRDNLRFGLEFEKSAFGKYNVDNAINAN
FRYSF
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